A Feasibility Study of Smoking Cessation Program in Radiation Oncology

Inclusion Criteria:

• Eligibility for Radiotherapy Patients
• age 18 years or older
• receiving three weeks or more of external beam radiotherapy
• report smoking one or more cigarettes in the past 30 days or self-identify as a smoker
• Cancer Stage:
• Stage I-III
• IVa Head and Neck Malignancy is allowed
• Stage I-IV breast, prostate, testis or lymphoma also allowed
• at least one year life expectancy
• have given written informed consent
• KPS 70-100

Eligibility for Family/Companions of Radiotherapy Patients (Note: Family members/companions are eligible for this protocol regardless of whether the index radiotherapy patient is eligible or willing to participate.)

• age 18 years or older
• at least one year life expectancy
• radiotherapy patient is receiving three weeks or more of external beam radiotherapy
• Person is committed to bringing/accompanying the patient to radiotherapy at least three days per week.
• report smoking one or more cigarettes in the past 30 days or self-identify as a smoker
• Family member/companion of patients under radiotherapy treatment for any stage of cancer
• have given written informed consent
• KPS 70-100

Exclusion Criteria:

• Exclusion Criteria for both Radiotherapy Patients and their Families/Companions
• serious or unstable cardiac, renal, hypertensive, pulmonary, endocrine, or neurologic disorders, as assessed by the study-site physician
• a current diagnosis of major depressive episode or a history of panic disorder, psychosis, bipolar disorder, or eating disorders
• pregnancy or lactation
• any history of allergy/intolerance or adverse reaction to bupropion
• history of seizure disorder, bulimia or anorexia nervosa
• use of an MAOi within 14 days
• current use of another antidepressant
• abrupt discontinuation of alcohol or sedatives
• unwilling/unable to meet with the behavioral interventionalist for 20 minutes, at least 3 days per week during the course of radiotherapy