Testování imunoterapie versus pozorování u pacientů s HPV rakovinou hrdla
Randomizovaná studie fáze III udržovací nivolumab versus pozorování u pacientů s lokálně pokročilým, středně rizikovým HPV pozitivním OPSCC
This phase III trials studies whether maintenance immunotherapy (nivolumab) following definitive treatment with radiation and chemotherapy (cisplatin) result in significant improvement in overall survival (time being alive) and progression-free survival (time being alive without cancer) for patients with intermediate risk human papillomavirus (HPV) positive oropharynx cancer (throat cancer) that has spread to nearby tissue or lymph nodes. Drugs used in chemotherapy such as cisplatin work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy rays to kill tumor cells and shrink tumors. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. It is not yet known whether chemotherapy and radiation therapy followed by maintenance nivolumab therapy works better than chemotherapy and radiation therapy alone in treating patients with HPV positive oropharyngeal cancer.
Přehled studie
Postavení
Podmínky
Detailní popis
PRIMARY OBJECTIVE:
I. To assess the efficacy of concurrent definitive therapy followed by nivolumab compared with concurrent definitive therapy followed by observation in terms of overall survival (OS).
SECONDARY OBJECTIVES:
I. To further assess the efficacy of nivolumab compared with observation in terms of:
Ia. To evaluate treatment effect within the subset of patients tested as PD-L1+ .
Ib. To evaluate the prognostic effect of baseline saliva and/or plasma HPV status .
Ic. To evaluate the prognostic effect of mutation burden among patients on the nivolumab arm.
Id. To evaluate the association of 12-week post therapy fludeoxyglucose F-18 (FDG) positron emission tomography(PET)/computed tomography (CT) OS and progression free survival (PFS).
Ie. To establish the prognostic value of standardized uptake value (SUV) max of primary tumor or neck nodal metastasis of baseline FDG PET/CT for OS (and/or PFS).
If. To correlate SUV max of primary tumor or nodal metastasis of baseline FDG PET/CT with PD-L1 expression (positive versus [vs.] negative).
Ig. To compare the PET based therapy response assessment (Hopkins criteria) to the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 assessment at 12 week post chemoradiation therapy, for patients who have a PET/CT scan at 12 weeks.
II. To assess the efficacy of concurrent definitive therapy followed by nivolumab in terms of progression free survival (PFS).
OUTLINE: Patients are randomized to Arm A or Arm B. Patients in Arm B may cross-over to Arm C with clearly documented disease progression.
ARM A: Patients receive cisplatin intravenously (IV) over 60 minutes weekly and intensity modulated radiation therapy (IMRT) 5 days a week for 7 weeks for a total of 35 fractions. Within 4 weeks after completion of concurrent therapy, patients receive nivolumab IV once weekly over 30 minutes every 4 weeks for 12 months in the absence of disease progression or unacceptable toxicity.
ARM B: Patients receive cisplatin IV over 60 minutes weekly and IMRT 5 days a week for 7 weeks for a total of 35 fractions, and then go on observation. Patients will be offered the option to cross-over to Arm C if they have clearly documented progression within 12 months from the end of cisplatin/radiation therapy.
ARM C: Patients receive nivolumab IV over 30 minutes every 4 weeks for 12 months in the absence of disease progression or unacceptable toxicity.
All patients undergo computed tomography (CT) or Fludeoxyglucose F-18 (FDG) positron emission tomography (PET)/CT scans throughout the trial. Patients may undergo echocardiography (ECHO) as clinically indicated. Additionally, patients undergo blood sample collection during screening.
After completion of study treatment, patients are followed up every 3-6 months for 3 years and then annually for a total of 10 years.
Typ studie
Zápis (Odhadovaný)
Fáze
- Fáze 3
Kontakty a umístění
Studijní místa
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Alabama
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Fairhope, Alabama, Spojené státy, 36532
- Thomas Hospital
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Mobile, Alabama, Spojené státy, 36607
- Mobile Infirmary Medical Center
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Alaska
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Anchorage, Alaska, Spojené státy, 98508
- Anchorage Associates in Radiation Medicine
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Anchorage, Alaska, Spojené státy, 99508
- Alaska Breast Care and Surgery LLC
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Anchorage, Alaska, Spojené státy, 99508
- Alaska Oncology and Hematology LLC
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Anchorage, Alaska, Spojené státy, 99508
- Alaska Women's Cancer Care
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Anchorage, Alaska, Spojené státy, 99508
- Anchorage Oncology Centre
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Anchorage, Alaska, Spojené státy, 99508
- Katmai Oncology Group
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Anchorage, Alaska, Spojené státy, 99508
- Providence Alaska Medical Center
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Anchorage, Alaska, Spojené státy, 99504
- Anchorage Radiation Therapy Center
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Fairbanks, Alaska, Spojené státy, 99701
- Fairbanks Memorial Hospital
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Arizona
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Goodyear, Arizona, Spojené státy, 85338
- CTCA at Western Regional Medical Center
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Kingman, Arizona, Spojené státy, 86401
- Kingman Regional Medical Center
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Phoenix, Arizona, Spojené státy, 85004
- Cancer Center at Saint Joseph's
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Arkansas
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Fort Smith, Arkansas, Spojené státy, 72903
- Mercy Hospital Fort Smith
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Hot Springs, Arkansas, Spojené státy, 71913
- CHI Saint Vincent Cancer Center Hot Springs
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California
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Antioch, California, Spojené státy, 94531
- Kaiser Permanente-Deer Valley Medical Center
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Arroyo Grande, California, Spojené státy, 93420
- PCR Oncology
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Arroyo Grande, California, Spojené státy, 93420
- Mission Hope Medical Oncology - Arroyo Grande
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Burbank, California, Spojené státy, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Carmichael, California, Spojené státy, 95608
- Mercy San Juan Medical Center
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Carmichael, California, Spojené státy, 95608
- Mercy Cancer Center - Carmichael
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Dublin, California, Spojené státy, 94568
- Kaiser Permanente Dublin
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Dublin, California, Spojené státy, 94568
- Epic Care-Dublin
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Elk Grove, California, Spojené státy, 95758
- Mercy Cancer Center - Elk Grove
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Emeryville, California, Spojené státy, 94608
- Bay Area Breast Surgeons Inc
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Emeryville, California, Spojené státy, 94608
- Epic Care Partners in Cancer Care
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Fremont, California, Spojené státy, 94538
- Kaiser Permanente-Fremont
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Fresno, California, Spojené státy, 93720
- Kaiser Permanente-Fresno
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Fresno, California, Spojené státy, 93720
- Fresno Cancer Center
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Long Beach, California, Spojené státy, 90822
- Tibor Rubin VA Medical Center
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Martinez, California, Spojené státy, 94553-3156
- Contra Costa Regional Medical Center
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Merced, California, Spojené státy, 95340
- Mercy Cancer Center
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Modesto, California, Spojené státy, 95356
- Kaiser Permanente-Modesto
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Napa, California, Spojené státy, 94558
- Providence Queen of The Valley
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Oakland, California, Spojené státy, 94611
- Kaiser Permanente-Oakland
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Oakland, California, Spojené státy, 94611
- Kaiser Permanente Oakland-Broadway
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Oakland, California, Spojené státy, 94609
- Alta Bates Summit Medical Center - Summit Campus
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Oakland, California, Spojené státy, 94609
- Bay Area Tumor Institute
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Palo Alto, California, Spojené státy, 94304
- VA Palo Alto Health Care System
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Rancho Cordova, California, Spojené státy, 95670
- Kaiser Permanente-Rancho Cordova Cancer Center
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Redwood City, California, Spojené státy, 94063
- Kaiser Permanente-Redwood City
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Richmond, California, Spojené státy, 94801
- Kaiser Permanente-Richmond
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Rocklin, California, Spojené státy, 95765
- Mercy Cancer Center - Rocklin
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Rohnert Park, California, Spojené státy, 94928
- Rohnert Park Cancer Center
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Roseville, California, Spojené státy, 95678
- The Permanente Medical Group-Roseville Radiation Oncology
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Roseville, California, Spojené státy, 95661
- Kaiser Permanente-Roseville
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Sacramento, California, Spojené státy, 95814
- Kaiser Permanente Downtown Commons
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Sacramento, California, Spojené státy, 95823
- South Sacramento Cancer Center
-
Sacramento, California, Spojené státy, 95816
- Mercy Cancer Center - Sacramento
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Salinas, California, Spojené státy, 93901
- Salinas Valley Memorial
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San Diego, California, Spojené státy, 92134
- Naval Medical Center -San Diego
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San Diego, California, Spojené státy, 92103
- UC San Diego Medical Center - Hillcrest
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San Francisco, California, Spojené státy, 94115
- Kaiser Permanente-San Francisco
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San Jose, California, Spojené státy, 95119
- Kaiser Permanente-Santa Teresa-San Jose
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San Leandro, California, Spojené státy, 94577
- Kaiser Permanente San Leandro
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San Luis Obispo, California, Spojené státy, 93401
- Pacific Central Coast Health Center-San Luis Obispo
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San Rafael, California, Spojené státy, 94903
- Kaiser San Rafael-Gallinas
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Santa Clara, California, Spojené státy, 95051
- Kaiser Permanente Medical Center - Santa Clara
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Santa Maria, California, Spojené státy, 93444
- Mission Hope Medical Oncology - Santa Maria
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Santa Rosa, California, Spojené státy, 95403
- Kaiser Permanente-Santa Rosa
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Santa Rosa, California, Spojené státy, 95403
- Providence Medical Foundation - Santa Rosa
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South San Francisco, California, Spojené státy, 94080
- Kaiser Permanente Cancer Treatment Center
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South San Francisco, California, Spojené státy, 94080
- Kaiser Permanente-South San Francisco
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Stockton, California, Spojené státy, 95210
- Kaiser Permanente-Stockton
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Vacaville, California, Spojené státy, 95688
- Kaiser Permanente Medical Center-Vacaville
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Vallejo, California, Spojené státy, 94589
- Kaiser Permanente-Vallejo
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Walnut Creek, California, Spojené státy, 94596
- Kaiser Permanente-Walnut Creek
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Walnut Creek, California, Spojené státy, 94597
- Epic Care Cyberknife Center
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Woodland, California, Spojené státy, 95695
- Woodland Memorial Hospital
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Colorado
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Aurora, Colorado, Spojené státy, 80012
- Rocky Mountain Cancer Centers-Aurora
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Aurora, Colorado, Spojené státy, 80012
- The Medical Center of Aurora
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Aurora, Colorado, Spojené státy, 80045
- UCHealth University of Colorado Hospital
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Boulder, Colorado, Spojené státy, 80303
- Boulder Community Foothills Hospital
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Boulder, Colorado, Spojené státy, 80304
- Rocky Mountain Cancer Centers-Boulder
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Centennial, Colorado, Spojené státy, 80112
- Rocky Mountain Cancer Centers - Centennial
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Colorado Springs, Colorado, Spojené státy, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, Spojené státy, 80909
- UCHealth Memorial Hospital Central
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Colorado Springs, Colorado, Spojené státy, 80907
- Rocky Mountain Cancer Centers-Penrose
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Colorado Springs, Colorado, Spojené státy, 80920
- Memorial Hospital North
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Colorado Springs, Colorado, Spojené státy, 80923
- Saint Francis Cancer Center
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Denver, Colorado, Spojené státy, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, Spojené státy, 80220
- Rose Medical Center
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Denver, Colorado, Spojené státy, 80218
- Rocky Mountain Cancer Centers-Midtown
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Denver, Colorado, Spojené státy, 80220
- Rocky Mountain Cancer Centers-Rose
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Denver, Colorado, Spojené státy, 80218
- Colorado Blood Cancer Institute
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Denver, Colorado, Spojené státy, 80204
- Cancer Center of Colorado at Sloan's Lake
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Denver, Colorado, Spojené státy, 80209
- The Women's Imaging Center
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Denver, Colorado, Spojené státy, 80206
- National Jewish Health-Main Campus
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Denver, Colorado, Spojené státy, 80220
- Western Surgical Care
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Denver, Colorado, Spojené státy, 80218
- Saint Joseph Hospital - Cancer Centers of Colorado
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Denver, Colorado, Spojené státy, 80210
- AdventHealth Porter
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Durango, Colorado, Spojené státy, 81301
- Mercy Medical Center
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Durango, Colorado, Spojené státy, 81301
- CommonSpirit Cancer Center Mercy
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Englewood, Colorado, Spojené státy, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, Spojené státy, 80113
- Swedish Medical Center
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Englewood, Colorado, Spojené státy, 80113
- Rocky Mountain Cancer Centers - Swedish
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Englewood, Colorado, Spojené státy, 80113
- The Melanoma and Skin Cancer Institute
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Fort Collins, Colorado, Spojené státy, 80524
- Poudre Valley Hospital
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Fort Collins, Colorado, Spojené státy, 80528
- Cancer Care and Hematology-Fort Collins
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Golden, Colorado, Spojené státy, 80401
- National Jewish Health-Western Hematology Oncology
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Grand Junction, Colorado, Spojené státy, 81501
- Saint Mary's Hospital and Regional Medical Center
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Greeley, Colorado, Spojené státy, 80631
- UCHealth Greeley Hospital
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Greeley, Colorado, Spojené státy, 80631
- Banner North Colorado Medical Center
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Lafayette, Colorado, Spojené státy, 80026
- Good Samaritan Hospital - Cancer Centers of Colorado
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Lakewood, Colorado, Spojené státy, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Lakewood, Colorado, Spojené státy, 80228
- CommonSpirit Saint Anthony Hospital Cancer Center
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Littleton, Colorado, Spojené státy, 80120
- Rocky Mountain Cancer Centers-Littleton
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Littleton, Colorado, Spojené státy, 80122
- AdventHealth Littleton
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Lone Tree, Colorado, Spojené státy, 80124
- Sky Ridge Medical Center
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Lone Tree, Colorado, Spojené státy, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
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Longmont, Colorado, Spojené státy, 80501
- Longmont United Hospital
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Longmont, Colorado, Spojené státy, 80501
- Rocky Mountain Cancer Centers-Longmont
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Loveland, Colorado, Spojené státy, 80538
- Medical Center of the Rockies
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Loveland, Colorado, Spojené státy, 80539
- Banner North Colorado Medical Center - Loveland Campus
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Parker, Colorado, Spojené státy, 80138
- AdventHealth Parker
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Pueblo, Colorado, Spojené státy, 81004
- Saint Mary Corwin Medical Center
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Thornton, Colorado, Spojené státy, 80260
- Rocky Mountain Cancer Centers-Thornton
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Thornton, Colorado, Spojené státy, 80260
- National Jewish Health-Northern Hematology Oncology
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Wheat Ridge, Colorado, Spojené státy, 80401
- Intermountain Health Lutheran Hospital
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Connecticut
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Greenwich, Connecticut, Spojené státy, 06830
- Smilow Cancer Hospital Care Center at Greenwich
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Guilford, Connecticut, Spojené státy, 06437
- Smilow Cancer Hospital Care Center - Guilford
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New Haven, Connecticut, Spojené státy, 06520
- Yale University
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New Haven, Connecticut, Spojené státy, 06510
- Smilow Cancer Center/Yale-New Haven Hospital
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North Haven, Connecticut, Spojené státy, 06473
- Yale-New Haven Hospital North Haven Medical Center
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Orange, Connecticut, Spojené státy, 06477
- Smilow Cancer Hospital-Orange Care Center
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Trumbull, Connecticut, Spojené státy, 06611
- Smilow Cancer Hospital Care Center-Trumbull
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Waterford, Connecticut, Spojené státy, 06385
- Smilow Cancer Hospital Care Center - Waterford
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Delaware
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Lewes, Delaware, Spojené státy, 19958
- Beebe Medical Center
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Millville, Delaware, Spojené státy, 19967
- Beebe South Coastal Health Campus
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Newark, Delaware, Spojené státy, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, Spojené státy, 19713
- Delaware Clinical and Laboratory Physicians PA
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Newark, Delaware, Spojené státy, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, Spojené státy, 19718
- Christiana Care Health System-Christiana Hospital
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Rehoboth Beach, Delaware, Spojené státy, 19971
- Beebe Health Campus
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District of Columbia
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Washington D.C., District of Columbia, Spojené státy, 20037
- George Washington University Medical Center
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Florida
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Deerfield Beach, Florida, Spojené státy, 33064
- Broward Health North
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Fort Lauderdale, Florida, Spojené státy, 33316
- Broward Health Medical Center
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Fort Lauderdale, Florida, Spojené státy, 33308
- Holy Cross Hospital
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Lakeland, Florida, Spojené státy, 33805
- The Watson Clinic
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Tampa, Florida, Spojené státy, 33612
- Moffitt Cancer Center
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Tampa, Florida, Spojené státy, 33607
- Moffitt Cancer Center-International Plaza
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Tampa, Florida, Spojené státy, 33612
- Moffitt Cancer Center - McKinley Campus
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Wesley Chapel, Florida, Spojené státy, 33544
- Moffitt Cancer Center at Wesley Chapel
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Georgia
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Atlanta, Georgia, Spojené státy, 30308
- Emory University Hospital Midtown
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Atlanta, Georgia, Spojené státy, 30322
- Emory University Hospital/Winship Cancer Institute
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Decatur, Georgia, Spojené státy, 30033
- Atlanta VA Medical Center
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Savannah, Georgia, Spojené státy, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Valdosta, Georgia, Spojené státy, 31602
- South Georgia Medical Center/Pearlman Cancer Center
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Hawaii
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Honolulu, Hawaii, Spojené státy, 96813
- Queen's Medical Center
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Honolulu, Hawaii, Spojené státy, 96817
- The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, Spojené státy, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, Spojené státy, 96813
- Queen's Cancer Cenrer - POB I
-
Honolulu, Hawaii, Spojené státy, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, Spojené státy, 96813
- University of Hawaii Cancer Center
-
Honolulu, Hawaii, Spojené státy, 96817
- Kuakini Medical Center
-
Honolulu, Hawaii, Spojené státy, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, Spojené státy, 96826
- Kapiolani Medical Center for Women and Children
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Honolulu, Hawaii, Spojené státy, 96819
- Kaiser Permanente Moanalua Medical Center
-
Lihue, Hawaii, Spojené státy, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
-
‘Aiea, Hawaii, Spojené státy, 96701
- Hawaii Cancer Care - Westridge
-
‘Aiea, Hawaii, Spojené státy, 96701
- Pali Momi Medical Center
-
‘Aiea, Hawaii, Spojené státy, 96701
- Queen's Cancer Center - Pearlridge
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‘Aiea, Hawaii, Spojené státy, 96701
- The Cancer Center of Hawaii-Pali Momi
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Idaho
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Boise, Idaho, Spojené státy, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Boise, Idaho, Spojené státy, 83712
- Saint Luke's Cancer Institute - Boise
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Caldwell, Idaho, Spojené státy, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
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Coeur d'Alene, Idaho, Spojené státy, 83814
- Kootenai Health - Coeur d'Alene
-
Emmett, Idaho, Spojené státy, 83617
- Walter Knox Memorial Hospital
-
Fruitland, Idaho, Spojené státy, 83619
- Saint Luke's Cancer Institute - Fruitland
-
Meridian, Idaho, Spojené státy, 83642
- Idaho Urologic Institute-Meridian
-
Meridian, Idaho, Spojené státy, 83642
- Saint Luke's Cancer Institute - Meridian
-
Nampa, Idaho, Spojené státy, 83687
- Saint Alphonsus Cancer Care Center-Nampa
-
Nampa, Idaho, Spojené státy, 83687
- Saint Luke's Cancer Institute - Nampa
-
Post Falls, Idaho, Spojené státy, 83854
- Kootenai Clinic Cancer Services - Post Falls
-
Sandpoint, Idaho, Spojené státy, 83864
- Kootenai Clinic Cancer Services - Sandpoint
-
Twin Falls, Idaho, Spojené státy, 83301
- Saint Luke's Cancer Institute - Twin Falls
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Illinois
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Alton, Illinois, Spojené státy, 62002
- OSF Saint Anthony's Health Center
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Aurora, Illinois, Spojené státy, 60504
- Rush-Copley Medical Center
-
Barrington, Illinois, Spojené státy, 60010
- Advocate Good Shepherd Hospital
-
Bloomington, Illinois, Spojené státy, 61704
- Illinois CancerCare-Bloomington
-
Canton, Illinois, Spojené státy, 61520
- Illinois CancerCare-Canton
-
Carbondale, Illinois, Spojené státy, 62902
- Memorial Hospital of Carbondale
-
Carterville, Illinois, Spojené státy, 62918
- SIH Cancer Institute
-
Carthage, Illinois, Spojené státy, 62321
- Illinois CancerCare-Carthage
-
Centralia, Illinois, Spojené státy, 62801
- Centralia Oncology Clinic
-
Centralia, Illinois, Spojené státy, 62801
- Saint Mary's Hospital
-
Chicago, Illinois, Spojené státy, 60611
- Northwestern University
-
Chicago, Illinois, Spojené státy, 60612
- University of Illinois
-
Chicago, Illinois, Spojené státy, 60612
- John H Stroger Jr Hospital of Cook County
-
Chicago, Illinois, Spojené státy, 60657
- Advocate Illinois Masonic Medical Center
-
Crystal Lake, Illinois, Spojené státy, 60014
- AMG Crystal Lake - Oncology
-
Danville, Illinois, Spojené státy, 61832
- Carle at The Riverfront
-
Decatur, Illinois, Spojené státy, 62526
- Decatur Memorial Hospital
-
Decatur, Illinois, Spojené státy, 62526
- Cancer Care Specialists of Illinois - Decatur
-
Dixon, Illinois, Spojené státy, 61021
- Illinois CancerCare-Dixon
-
Downers Grove, Illinois, Spojené státy, 60515
- Advocate Good Samaritan Hospital
-
Effingham, Illinois, Spojené státy, 62401
- Crossroads Cancer Center
-
Effingham, Illinois, Spojené státy, 62401
- Carle Physician Group-Effingham
-
Elgin, Illinois, Spojené státy, 60123
- Advocate Sherman Hospital
-
Eureka, Illinois, Spojené státy, 61530
- Illinois CancerCare-Eureka
-
Galesburg, Illinois, Spojené státy, 61401
- Western Illinois Cancer Treatment Center
-
Galesburg, Illinois, Spojené státy, 61401
- Illinois CancerCare-Galesburg
-
Hazel Crest, Illinois, Spojené státy, 60429
- Advocate South Suburban Hospital
-
Hinsdale, Illinois, Spojené státy, 60521
- UChicago Medicine AdventHealth Cancer Institute Hinsdale
-
Kewanee, Illinois, Spojené státy, 61443
- Illinois CancerCare-Kewanee Clinic
-
Lake Forest, Illinois, Spojené státy, 60045
- Northwestern Medicine Lake Forest Hospital
-
Libertyville, Illinois, Spojené státy, 60048
- Condell Memorial Hospital
-
Libertyville, Illinois, Spojené státy, 60048
- AMG Libertyville - Oncology
-
Macomb, Illinois, Spojené státy, 61455
- Illinois CancerCare-Macomb
-
Mattoon, Illinois, Spojené státy, 61938
- Carle Physician Group-Mattoon/Charleston
-
Mount Vernon, Illinois, Spojené státy, 62864
- SSM Health Good Samaritan
-
O'Fallon, Illinois, Spojené státy, 62269
- Cancer Care Center of O'Fallon
-
O'Fallon, Illinois, Spojené státy, 62269
- HSHS Saint Elizabeth's Hospital
-
Oak Lawn, Illinois, Spojené státy, 60453-2699
- Advocate Christ Medical Center
-
Ottawa, Illinois, Spojené státy, 61350
- Illinois CancerCare-Ottawa Clinic
-
Palos Heights, Illinois, Spojené státy, 60463
- Advocate High Tech Medical Park
-
Park Ridge, Illinois, Spojené státy, 60068
- Advocate Lutheran General Hospital
-
Pekin, Illinois, Spojené státy, 61554
- Illinois CancerCare-Pekin
-
Pekin, Illinois, Spojené státy, 61554
- OSF Saint Francis Radiation Oncology at Pekin
-
Peoria, Illinois, Spojené státy, 61636
- Methodist Medical Center of Illinois
-
Peoria, Illinois, Spojené státy, 61637
- OSF Saint Francis Medical Center
-
Peoria, Illinois, Spojené státy, 61615
- Illinois CancerCare-Peoria
-
Peoria, Illinois, Spojené státy, 61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
-
Peru, Illinois, Spojené státy, 61354
- Illinois CancerCare-Peru
-
Peru, Illinois, Spojené státy, 61354
- Valley Radiation Oncology
-
Princeton, Illinois, Spojené státy, 61356
- Illinois CancerCare-Princeton
-
Springfield, Illinois, Spojené státy, 62702
- Southern Illinois University School of Medicine
-
Springfield, Illinois, Spojené státy, 62702
- Springfield Clinic
-
Springfield, Illinois, Spojené státy, 62781
- Springfield Memorial Hospital
-
Swansea, Illinois, Spojené státy, 62226
- Southwest Illinois Health Services LLP
-
Urbana, Illinois, Spojené státy, 61801
- Carle Cancer Center
-
Urbana, Illinois, Spojené státy, 61801
- The Carle Foundation Hospital
-
Washington, Illinois, Spojené státy, 61571
- Illinois CancerCare - Washington
-
Yorkville, Illinois, Spojené státy, 60560
- Rush-Copley Healthcare Center
-
-
Indiana
-
Fort Wayne, Indiana, Spojené státy, 46845
- Parkview Regional Medical Center
-
Indianapolis, Indiana, Spojené státy, 46237
- Franciscan Health Indianapolis
-
Indianapolis, Indiana, Spojené státy, 46219
- Community Cancer Center East
-
Indianapolis, Indiana, Spojené státy, 46227
- Community Cancer Center South
-
Indianapolis, Indiana, Spojené státy, 46256
- Community Cancer Center North
-
Kokomo, Indiana, Spojené státy, 46904
- Community Howard Regional Health
-
Michigan City, Indiana, Spojené státy, 46360
- Woodland Cancer Care Center
-
Mooresville, Indiana, Spojené státy, 46158
- Franciscan Health Mooresville
-
Terre Haute, Indiana, Spojené státy, 47804
- Union Hospital
-
-
Iowa
-
Ames, Iowa, Spojené státy, 50010
- Mary Greeley Medical Center
-
Ames, Iowa, Spojené státy, 50010
- McFarland Clinic - Ames
-
Ankeny, Iowa, Spojené státy, 50023
- UI Health Care Mission Cancer and Blood - Ankeny Clinic
-
Boone, Iowa, Spojené státy, 50036
- McFarland Clinic - Boone
-
Carroll, Iowa, Spojené státy, 51401
- Saint Anthony Regional Hospital
-
Clive, Iowa, Spojené státy, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, Spojené státy, 50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
-
Council Bluffs, Iowa, Spojené státy, 51503
- Alegent Health Mercy Hospital
-
Creston, Iowa, Spojené státy, 50801
- Greater Regional Medical Center
-
Des Moines, Iowa, Spojené státy, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, Spojené státy, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Spojené státy, 50314
- Broadlawns Medical Center
-
Des Moines, Iowa, Spojené státy, 50316
- Iowa Lutheran Hospital
-
Des Moines, Iowa, Spojené státy, 50309
- UI Health Care Mission Cancer and Blood - Des Moines Clinic
-
Des Moines, Iowa, Spojené státy, 50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
-
Fort Dodge, Iowa, Spojené státy, 50501
- McFarland Clinic - Trinity Cancer Center
-
Fort Dodge, Iowa, Spojené státy, 50501
- UI Healthcare Mission Cancer and Blood - Fort Dodge
-
Jefferson, Iowa, Spojené státy, 50129
- McFarland Clinic - Jefferson
-
Marshalltown, Iowa, Spojené státy, 50158
- McFarland Clinic - Marshalltown
-
West Des Moines, Iowa, Spojené státy, 50266-7700
- Methodist West Hospital
-
West Des Moines, Iowa, Spojené státy, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Garden City, Kansas, Spojené státy, 67846
- Central Care Cancer Center - Garden City
-
Great Bend, Kansas, Spojené státy, 67530
- Central Care Cancer Center - Great Bend
-
-
Kentucky
-
Bardstown, Kentucky, Spojené státy, 40004
- CommonSpirit Saint Joseph Hospital - Bardstown
-
Corbin, Kentucky, Spojené státy, 40701
- Commonwealth Cancer Center-Corbin
-
Lexington, Kentucky, Spojené státy, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, Spojené státy, 40509
- CommonSpirit Saint Joseph Medical Center - East Lexington
-
Lexington, Kentucky, Spojené státy, 40504
- CommonSpirit Saint Joseph Hospital - Lexington
-
London, Kentucky, Spojené státy, 40741
- CommonSpirit Saint Joseph Hospital London
-
Louisville, Kentucky, Spojené státy, 40202
- The James Graham Brown Cancer Center at University of Louisville
-
Louisville, Kentucky, Spojené státy, 40202
- Jewish Hospital
-
Louisville, Kentucky, Spojené státy, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, Spojené státy, 40215
- Saints Mary and Elizabeth Hospital
-
Shepherdsville, Kentucky, Spojené státy, 40165
- Jewish Hospital Medical Center South
-
-
Louisiana
-
Baton Rouge, Louisiana, Spojené státy, 70805
- LSU Health Baton Rouge-North Clinic
-
Baton Rouge, Louisiana, Spojené státy, 70809
- Louisiana Hematology Oncology Associates LLC
-
Baton Rouge, Louisiana, Spojené státy, 70809
- Mary Bird Perkins Cancer Center
-
Baton Rouge, Louisiana, Spojené státy, 70808
- Our Lady of The Lake
-
Baton Rouge, Louisiana, Spojené státy, 70808
- Our Lady of the Lake Physician Group
-
New Orleans, Louisiana, Spojené státy, 70112
- University Medical Center New Orleans
-
New Orleans, Louisiana, Spojené státy, 70112
- Louisiana State University Health Science Center
-
-
Maryland
-
Baltimore, Maryland, Spojené státy, 21204
- Greater Baltimore Medical Center
-
Baltimore, Maryland, Spojené státy, 21201
- University of Maryland/Greenebaum Cancer Center
-
Bel Air, Maryland, Spojené státy, 21014
- UM Upper Chesapeake Medical Center
-
-
Massachusetts
-
Boston, Massachusetts, Spojené státy, 02111
- Tufts Medical Center
-
Lowell, Massachusetts, Spojené státy, 01854
- Lowell General Hospital
-
Springfield, Massachusetts, Spojené státy, 01104
- Mercy Medical Center
-
Worcester, Massachusetts, Spojené státy, 01655
- UMass Memorial Medical Center - University Campus
-
-
Michigan
-
Ann Arbor, Michigan, Spojené státy, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Battle Creek, Michigan, Spojené státy, 49017
- Bronson Battle Creek
-
Bay City, Michigan, Spojené státy, 48706
- McLaren Cancer Institute-Bay City
-
Brighton, Michigan, Spojené státy, 48114
- Trinity Health IHA Medical Group Hematology Oncology - Brighton
-
Brighton, Michigan, Spojené státy, 48114
- Trinity Health Medical Center - Brighton
-
Canton, Michigan, Spojené státy, 48188
- Trinity Health IHA Medical Group Hematology Oncology - Canton
-
Canton, Michigan, Spojené státy, 48188
- Trinity Health Medical Center - Canton
-
Caro, Michigan, Spojené státy, 48723
- Caro Cancer Center
-
Chelsea, Michigan, Spojené státy, 48118
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
-
Chelsea, Michigan, Spojené státy, 48118
- Chelsea Hospital
-
Clarkston, Michigan, Spojené státy, 48346
- McLaren Cancer Institute-Clarkston
-
Clarkston, Michigan, Spojené státy, 48346
- Hematology Oncology Consultants-Clarkston
-
Clarkston, Michigan, Spojené státy, 48346
- Newland Medical Associates-Clarkston
-
Detroit, Michigan, Spojené státy, 48201
- Wayne State University/Karmanos Cancer Institute
-
Detroit, Michigan, Spojené státy, 48236
- Henry Ford Health Saint John Hospital
-
East China Township, Michigan, Spojené státy, 48054
- Henry Ford River District Hospital
-
Farmington Hills, Michigan, Spojené státy, 48334
- Weisberg Cancer Treatment Center
-
Flint, Michigan, Spojené státy, 48532
- McLaren Cancer Institute-Flint
-
Flint, Michigan, Spojené státy, 48532
- Singh and Arora Hematology Oncology PC
-
Flint, Michigan, Spojené státy, 48503
- Hurley Medical Center
-
Flint, Michigan, Spojené státy, 48503
- Genesee Hematology Oncology PC
-
Flint, Michigan, Spojené státy, 48503
- Genesys Hurley Cancer Institute
-
Flint, Michigan, Spojené státy, 48503
- Cancer Hematology Centers - Flint
-
Grand Rapids, Michigan, Spojené státy, 49503
- Trinity Health Grand Rapids Hospital
-
Grand Rapids, Michigan, Spojené státy, 49503
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital
-
Grand Rapids, Michigan, Spojené státy, 49503
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
-
Grosse Pointe Woods, Michigan, Spojené státy, 48236
- Henry Ford Saint John Hospital - Academic
-
Grosse Pointe Woods, Michigan, Spojené státy, 48236
- Henry Ford Saint John Hospital - Breast
-
Grosse Pointe Woods, Michigan, Spojené státy, 48236
- Henry Ford Saint John Hospital - Van Elslander
-
Kalamazoo, Michigan, Spojené státy, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, Spojené státy, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, Spojené státy, 49009
- Beacon Kalamazoo Cancer Center
-
Kalamazoo, Michigan, Spojené státy, 49048
- Beacon Kalamazoo
-
Lansing, Michigan, Spojené státy, 48912
- Mid-Michigan Physicians-Lansing
-
Lansing, Michigan, Spojené státy, 48910
- Karmanos Cancer Institute at McLaren Greater Lansing
-
Lansing, Michigan, Spojené státy, 48912
- University of Michigan Health - Sparrow Lansing
-
Lapeer, Michigan, Spojené státy, 48446
- McLaren Cancer Institute-Lapeer Region
-
Livonia, Michigan, Spojené státy, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Livonia, Michigan, Spojené státy, 48154
- Hope Cancer Clinic
-
Macomb, Michigan, Spojené státy, 48044
- Henry Ford Warren Hospital - Breast Macomb
-
Macomb, Michigan, Spojené státy, 48044
- Henry Ford Saint John Hospital - Macomb Medical
-
Marlette, Michigan, Spojené státy, 48453
- Saint Mary's Oncology/Hematology Associates of Marlette
-
Mount Clemens, Michigan, Spojené státy, 48043
- McLaren Cancer Institute-Macomb
-
Mount Pleasant, Michigan, Spojené státy, 48858
- McLaren Cancer Institute-Central Michigan
-
Muskegon, Michigan, Spojené státy, 49444
- Trinity Health Muskegon Hospital
-
Niles, Michigan, Spojené státy, 49120
- Corewell Health Lakeland Hospitals - Niles Hospital
-
Norton Shores, Michigan, Spojené státy, 49444
- Cancer and Hematology Centers of Western Michigan - Norton Shores
-
Petoskey, Michigan, Spojené státy, 49770
- McLaren Cancer Institute-Northern Michigan
-
Pontiac, Michigan, Spojené státy, 48341
- Hope Cancer Center
-
Pontiac, Michigan, Spojené státy, 48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Pontiac, Michigan, Spojené státy, 48341
- Michigan Healthcare Professionals Pontiac
-
Pontiac, Michigan, Spojené státy, 48341
- Trinity Health IHA Medical Group-Alice Gustafson Center
-
Port Huron, Michigan, Spojené státy, 48060
- McLaren-Port Huron
-
Reed City, Michigan, Spojené státy, 49677
- Corewell Health Reed City Hospital
-
Rochester Hills, Michigan, Spojené státy, 48309
- Henry Ford Rochester Hospital
-
Saginaw, Michigan, Spojené státy, 48604
- Oncology Hematology Associates of Saginaw Valley PC
-
Saginaw, Michigan, Spojené státy, 48601
- MyMichigan Medical Center Saginaw
-
Saint Joseph, Michigan, Spojené státy, 49085
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
-
Saint Joseph, Michigan, Spojené státy, 49085
- Corewell Health Lakeland Hospitals - Saint Joseph Hospital
-
Sterling Heights, Michigan, Spojené státy, 48312
- Bhadresh Nayak MD PC-Sterling Heights
-
Tawas City, Michigan, Spojené státy, 48764
- MyMichigan Medical Center Tawas
-
Traverse City, Michigan, Spojené státy, 49684
- Munson Medical Center
-
Warren, Michigan, Spojené státy, 48088
- Advanced Breast Care Center PLLC
-
Warren, Michigan, Spojené státy, 48093
- Macomb Hematology Oncology PC
-
Warren, Michigan, Spojené státy, 48093
- Henry Ford Madison Heights Hospital - Breast
-
Warren, Michigan, Spojené státy, 48093
- Henry Ford Health Warren Hospital
-
Warren, Michigan, Spojené státy, 48093
- Henry Ford Warren Hospital - GLCMS
-
West Branch, Michigan, Spojené státy, 48661
- Saint Mary's Oncology/Hematology Associates of West Branch
-
Wyoming, Michigan, Spojené státy, 49519
- University of Michigan Health - West
-
Ypsilanti, Michigan, Spojené státy, 48197
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
-
Ypsilanti, Michigan, Spojené státy, 48106
- Huron Gastroenterology PC
-
-
Minnesota
-
Bemidji, Minnesota, Spojené státy, 56601
- Sanford Joe Lueken Cancer Center
-
Burnsville, Minnesota, Spojené státy, 55337
- Fairview Ridges Hospital
-
Burnsville, Minnesota, Spojené státy, 55337
- Minnesota Oncology - Burnsville
-
Cambridge, Minnesota, Spojené státy, 55008
- Cambridge Medical Center
-
Coon Rapids, Minnesota, Spojené státy, 55433
- Mercy Hospital
-
Edina, Minnesota, Spojené státy, 55435
- Fairview Southdale Hospital
-
Fridley, Minnesota, Spojené státy, 55432
- Unity Hospital
-
Maple Grove, Minnesota, Spojené státy, 55369
- Fairview Clinics and Surgery Center Maple Grove
-
Maplewood, Minnesota, Spojené státy, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Spojené státy, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Spojené státy, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Spojené státy, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Spojené státy, 55454
- Health Partners Inc
-
Minneapolis, Minnesota, Spojené státy, 55417
- Minneapolis VA Medical Center
-
Monticello, Minnesota, Spojené státy, 55362
- Monticello Cancer Center
-
New Ulm, Minnesota, Spojené státy, 56073
- New Ulm Medical Center
-
Princeton, Minnesota, Spojené státy, 55371
- Fairview Northland Medical Center
-
Robbinsdale, Minnesota, Spojené státy, 55422
- North Memorial Medical Health Center
-
Saint Louis Park, Minnesota, Spojené státy, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, Spojené státy, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Spojené státy, 55102
- United Hospital
-
Shakopee, Minnesota, Spojené státy, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Spojené státy, 55082
- Lakeview Hospital
-
Thief River Falls, Minnesota, Spojené státy, 56701
- Sanford Thief River Falls Medical Center
-
Waconia, Minnesota, Spojené státy, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Spojené státy, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Spojené státy, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
Worthington, Minnesota, Spojené státy, 56187
- Sanford Cancer Center Worthington
-
Wyoming, Minnesota, Spojené státy, 55092
- Fairview Lakes Medical Center
-
-
Missouri
-
Ballwin, Missouri, Spojené státy, 63011
- Mercy Oncology and Hematology - Clayton-Clarkson
-
Bolivar, Missouri, Spojené státy, 65613
- Central Care Cancer Center - Bolivar
-
Bonne Terre, Missouri, Spojené státy, 63628
- Parkland Health Center-Bonne Terre
-
Branson, Missouri, Spojené státy, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, Spojené státy, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Spojené státy, 63703
- Mercy Cancer Center - Cape Girardeau
-
Jefferson City, Missouri, Spojené státy, 65109
- MU Health Care Goldschmidt Cancer Center
-
Joplin, Missouri, Spojené státy, 64804
- Freeman Health System
-
Joplin, Missouri, Spojené státy, 64804
- Mercy Hospital Joplin
-
Rolla, Missouri, Spojené státy, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Rolla, Missouri, Spojené státy, 65401
- Phelps Health Delbert Day Cancer Institute
-
Saint Joseph, Missouri, Spojené státy, 64506
- Heartland Regional Medical Center
-
Sainte Genevieve, Missouri, Spojené státy, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, Spojené státy, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Spojené státy, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, Spojené státy, 63131
- Missouri Baptist Medical Center
-
St Louis, Missouri, Spojené státy, 63109
- Mercy Infusion Center - Chippewa
-
St Louis, Missouri, Spojené státy, 63141
- Mercy Hospital Saint Louis
-
St Louis, Missouri, Spojené státy, 63128
- Mercy Hospital South
-
Sullivan, Missouri, Spojené státy, 63080
- Missouri Baptist Sullivan Hospital
-
Washington, Missouri, Spojené státy, 63090
- Mercy Hospital Washington
-
-
Montana
-
Anaconda, Montana, Spojené státy, 59711
- Community Hospital of Anaconda
-
Billings, Montana, Spojené státy, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, Spojené státy, 59101
- Saint Vincent Healthcare
-
Billings, Montana, Spojené státy, 59102
- Saint Vincent Frontier Cancer Center
-
Bozeman, Montana, Spojené státy, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, Spojené státy, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Spojené státy, 59405
- Great Falls Clinic
-
Great Falls, Montana, Spojené státy, 59405
- Benefis Sletten Cancer Institute
-
Helena, Montana, Spojené státy, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, Spojené státy, 59901
- Logan Health Medical Center
-
Missoula, Montana, Spojené státy, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, Spojené státy, 59804
- Community Medical Center
-
-
Nebraska
-
Bellevue, Nebraska, Spojené státy, 68123
- Nebraska Medicine-Bellevue
-
Grand Island, Nebraska, Spojené státy, 68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Kearney, Nebraska, Spojené státy, 68847
- CHI Health Good Samaritan
-
Lincoln, Nebraska, Spojené státy, 68510
- Saint Elizabeth Regional Medical Center
-
Omaha, Nebraska, Spojené státy, 68198
- University of Nebraska Medical Center
-
Omaha, Nebraska, Spojené státy, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Spojené státy, 68118
- Nebraska Medicine-Village Pointe
-
Omaha, Nebraska, Spojené státy, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, Spojené státy, 68130
- Alegent Health Lakeside Hospital
-
Papillion, Nebraska, Spojené státy, 68046
- Midlands Community Hospital
-
-
Nevada
-
Carson City, Nevada, Spojené státy, 89703
- Carson Tahoe Regional Medical Center
-
Henderson, Nevada, Spojené státy, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Spojené státy, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, Spojené státy, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, Spojené státy, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, Spojené státy, 89052
- Comprehensive Cancer Centers of Nevada-Horizon Ridge
-
Henderson, Nevada, Spojené státy, 89074
- Las Vegas Urology - Green Valley
-
Henderson, Nevada, Spojené státy, 89074
- Las Vegas Urology - Pebble
-
Henderson, Nevada, Spojené státy, 89074
- Urology Specialists of Nevada - Green Valley
-
Henderson, Nevada, Spojené státy, 89074
- Oncology Las Vegas - Henderson
-
Las Vegas, Nevada, Spojené státy, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, Spojené státy, 89109
- Sunrise Hospital and Medical Center
-
Las Vegas, Nevada, Spojené státy, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, Spojené státy, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Spojené státy, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Spojené státy, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Spojené státy, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, Spojené státy, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, Spojené státy, 89144
- Comprehensive Cancer Centers of Nevada - Town Center
-
Las Vegas, Nevada, Spojené státy, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Spojené státy, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Spojené státy, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Spojené státy, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, Spojené státy, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, Spojené státy, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, Spojené státy, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, Spojené státy, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, Spojené státy, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, Spojené státy, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, Spojené státy, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, Spojené státy, 89128
- Ann M Wierman MD LTD
-
Las Vegas, Nevada, Spojené státy, 89074
- Las Vegas Urology - Pecos
-
Las Vegas, Nevada, Spojené státy, 89102
- Desert West Surgery
-
Las Vegas, Nevada, Spojené státy, 89103
- Hope Cancer Care of Nevada
-
Las Vegas, Nevada, Spojené státy, 89106
- Urology Specialists of Nevada - Central
-
Las Vegas, Nevada, Spojené státy, 89113
- Las Vegas Prostate Cancer Center
-
Las Vegas, Nevada, Spojené státy, 89113
- Las Vegas Urology - Sunset
-
Las Vegas, Nevada, Spojené státy, 89128
- Las Vegas Urology - Cathedral Rock
-
Las Vegas, Nevada, Spojené státy, 89128
- Las Vegas Urology - Smoke Ranch
-
Las Vegas, Nevada, Spojené státy, 89128
- Urology Specialists of Nevada - Northwest
-
Las Vegas, Nevada, Spojené státy, 89169
- University Cancer Center
-
Las Vegas, Nevada, Spojené státy, 89113
- Urology Specialists of Nevada - Southwest
-
Las Vegas, Nevada, Spojené státy, 89128
- Oncology Las Vegas - Tenaya
-
Las Vegas, Nevada, Spojené státy, 89183
- OptumCare Cancer Care at Fort Apache
-
Pahrump, Nevada, Spojené státy, 89048
- Hope Cancer Care of Nevada-Pahrump
-
Reno, Nevada, Spojené státy, 89502
- Renown Regional Medical Center
-
Reno, Nevada, Spojené státy, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, Spojené státy, 89509
- Radiation Oncology Associates
-
-
New Hampshire
-
Lebanon, New Hampshire, Spojené státy, 03756
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
-
New Jersey
-
Cape May Court House, New Jersey, Spojené státy, 08210
- AtlantiCare Health Park-Cape May Court House
-
Egg Harbor, New Jersey, Spojené státy, 08234
- AtlantiCare Surgery Center
-
Hamilton, New Jersey, Spojené státy, 08690
- The Cancer Institute of New Jersey Hamilton
-
Jersey City, New Jersey, Spojené státy, 07302
- Jersey City Medical Center
-
Livingston, New Jersey, Spojené státy, 07039
- Cooperman Barnabas Medical Center
-
Moorestown, New Jersey, Spojené státy, 08057
- Virtua Samson Cancer Center
-
Morristown, New Jersey, Spojené státy, 07960
- Morristown Medical Center
-
Mount Holly, New Jersey, Spojené státy, 08060
- Virtua Memorial
-
New Brunswick, New Jersey, Spojené státy, 08903
- Rutgers Cancer Institute of New Jersey
-
Newark, New Jersey, Spojené státy, 07101
- Rutgers New Jersey Medical School
-
Summit, New Jersey, Spojené státy, 07902
- Overlook Hospital
-
Voorhees Township, New Jersey, Spojené státy, 08043
- Virtua Voorhees
-
-
New Mexico
-
Albuquerque, New Mexico, Spojené státy, 87106
- University of New Mexico Cancer Center
-
-
New York
-
Brooklyn, New York, Spojené státy, 11215
- New York-Presbyterian/Brooklyn Methodist Hospital
-
Buffalo, New York, Spojené státy, 14263
- Roswell Park Cancer Institute
-
New York, New York, Spojené státy, 10065
- NYP/Weill Cornell Medical Center
-
Rochester, New York, Spojené státy, 14642
- University of Rochester
-
Stony Brook, New York, Spojené státy, 11794
- Stony Brook University Medical Center
-
Syracuse, New York, Spojené státy, 13210
- State University of New York Upstate Medical University
-
Syracuse, New York, Spojené státy, 13215
- SUNY Upstate Medical Center-Community Campus
-
The Bronx, New York, Spojené státy, 10461
- Montefiore Medical Center-Einstein Campus
-
The Bronx, New York, Spojené státy, 10467
- Montefiore Medical Center - Moses Campus
-
The Bronx, New York, Spojené státy, 10461
- Montefiore Medical Center-Weiler Hospital
-
-
North Carolina
-
Asheville, North Carolina, Spojené státy, 28803
- AdventHealth Infusion Center Asheville
-
Charlotte, North Carolina, Spojené státy, 28204
- Novant Health Presbyterian Medical Center
-
Clyde, North Carolina, Spojené státy, 28721
- AdventHealth Infusion Center Haywood
-
Gastonia, North Carolina, Spojené státy, 28054
- CaroMont Regional Medical Center
-
Greenville, North Carolina, Spojené státy, 27834
- East Carolina University
-
Hendersonville, North Carolina, Spojené státy, 28792
- AdventHealth Hendersonville
-
Huntersville, North Carolina, Spojené státy, 28078
- Novant Health Cancer Institute - Huntersville
-
Huntersville, North Carolina, Spojené státy, 28078
- Novant Health Presbyterian Medical Center Huntersville
-
Kernersville, North Carolina, Spojené státy, 27284
- Novant Health Cancer Institute - Kernersville
-
Matthews, North Carolina, Spojené státy, 28105
- Novant Health Cancer Institute - Matthews
-
Mooresville, North Carolina, Spojené státy, 28117
- Novant Health Cancer Institute - Mooresville
-
Mount Airy, North Carolina, Spojené státy, 27030
- Novant Health Cancer Institute - Mount Airy
-
New Bern, North Carolina, Spojené státy, 28561
- CarolinaEast Medical Center
-
North Wilkesboro, North Carolina, Spojené státy, 28659
- Novant Health Cancer Institute - Wilkesboro
-
Statesville, North Carolina, Spojené státy, 28625
- Novant Health Cancer Institute - Statesville
-
Thomasville, North Carolina, Spojené státy, 27360
- Novant Health Cancer Institute - Thomasville
-
Weaverville, North Carolina, Spojené státy, 28787
- AdventHealth Infusion Center Weaverville
-
Winston-Salem, North Carolina, Spojené státy, 27103
- Novant Health Forsyth Medical Center
-
-
North Dakota
-
Bismarck, North Dakota, Spojené státy, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, Spojené státy, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, Spojené státy, 58122
- Sanford Broadway Medical Center
-
Fargo, North Dakota, Spojené státy, 58103
- Sanford South University Medical Center
-
Fargo, North Dakota, Spojené státy, 58103
- Southpointe-Sanford Medical Center Fargo
-
Fargo, North Dakota, Spojené státy, 58104
- Sanford Medical Center Fargo
-
-
Ohio
-
Akron, Ohio, Spojené státy, 44304
- Summa Health System - Akron Campus
-
Avon, Ohio, Spojené státy, 44011
- UH Seidman Cancer Center at UH Avon Health Center
-
Barberton, Ohio, Spojené státy, 44203
- Summa Health System - Barberton Campus
-
Beachwood, Ohio, Spojené státy, 44122
- UHHS-Chagrin Highlands Medical Center
-
Canton, Ohio, Spojené státy, 44708
- Cleveland Clinic Mercy Hospital
-
Centerville, Ohio, Spojené státy, 45459
- Miami Valley Hospital South
-
Chardon, Ohio, Spojené státy, 44024
- Geauga Hospital
-
Cincinnati, Ohio, Spojené státy, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, Spojené státy, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, Spojené státy, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, Spojené státy, 45255
- TriHealth Cancer Institute-Anderson
-
Cleveland, Ohio, Spojené státy, 44106
- Case Western Reserve University
-
Cleveland, Ohio, Spojené státy, 44109
- MetroHealth Medical Center
-
Cleveland, Ohio, Spojené státy, 44195
- Cleveland Clinic Foundation
-
Cleveland, Ohio, Spojené státy, 44111
- Cleveland Clinic Cancer Center/Fairview Hospital
-
Columbus, Ohio, Spojené státy, 43210
- Ohio State University Comprehensive Cancer Center
-
Dayton, Ohio, Spojené státy, 45409
- Miami Valley Hospital
-
Dayton, Ohio, Spojené státy, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, Spojené státy, 45409
- Premier Blood and Cancer Center
-
Elyria, Ohio, Spojené státy, 44035
- Mercy Cancer Center-Elyria
-
Franklin, Ohio, Spojené státy, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Greenville, Ohio, Spojené státy, 45331
- Miami Valley Cancer Care and Infusion
-
Mansfield, Ohio, Spojené státy, 44906
- Cleveland Clinic Cancer Center Mansfield
-
Mayfield Heights, Ohio, Spojené státy, 44124
- Hillcrest Hospital Cancer Center
-
Medina, Ohio, Spojené státy, 44256
- Summa Health Medina Medical Center
-
Mentor, Ohio, Spojené státy, 44060
- UH Seidman Cancer Center at Lake Health Mentor Campus
-
Middleburg Heights, Ohio, Spojené státy, 44130
- UH Seidman Cancer Center at Southwest General Hospital
-
Parma, Ohio, Spojené státy, 44129
- University Hospitals Parma Medical Center
-
Ravenna, Ohio, Spojené státy, 44266
- University Hospitals Portage Medical Center
-
Sandusky, Ohio, Spojené státy, 44870
- North Coast Cancer Care
-
Strongsville, Ohio, Spojené státy, 44136
- Cleveland Clinic Cancer Center Strongsville
-
Troy, Ohio, Spojené státy, 45373
- Upper Valley Medical Center
-
Westlake, Ohio, Spojené státy, 44145
- UH Seidman Cancer Center at Saint John Medical Center
-
Westlake, Ohio, Spojené státy, 44145
- UHHS-Westlake Medical Center
-
-
Oklahoma
-
Lawton, Oklahoma, Spojené státy, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, Spojené státy, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, Spojené státy, 73120
- Mercy Hospital Oklahoma City
-
Tulsa, Oklahoma, Spojené státy, 74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
-
Oregon
-
Baker City, Oregon, Spojené státy, 97814
- Saint Alphonsus Cancer Care Center-Baker City
-
Bend, Oregon, Spojené státy, 97701
- Saint Charles Health System
-
Clackamas, Oregon, Spojené státy, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, Spojené státy, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, Spojené státy, 97420
- Bay Area Hospital
-
Newberg, Oregon, Spojené státy, 97132
- Providence Newberg Medical Center
-
Ontario, Oregon, Spojené státy, 97914
- Saint Alphonsus Cancer Care Center-Ontario
-
Oregon City, Oregon, Spojené státy, 97045
- Providence Willamette Falls Medical Center
-
Portland, Oregon, Spojené státy, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Spojené státy, 97225
- Providence Saint Vincent Medical Center
-
Redmond, Oregon, Spojené státy, 97756
- Saint Charles Health System-Redmond
-
-
Pennsylvania
-
Allentown, Pennsylvania, Spojené státy, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, Spojené státy, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Chadds Ford, Pennsylvania, Spojené státy, 19317
- Christiana Care Health System-Concord Health Center
-
Danville, Pennsylvania, Spojené státy, 17822
- Geisinger Medical Center
-
East Stroudsburg, Pennsylvania, Spojené státy, 18301
- Pocono Medical Center
-
Erie, Pennsylvania, Spojené státy, 16505
- UPMC Hillman Cancer Center Erie
-
Farrell, Pennsylvania, Spojené státy, 16121
- UPMC Cancer Center at UPMC Horizon
-
Hazleton, Pennsylvania, Spojené státy, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hazleton, Pennsylvania, Spojené státy, 18201
- Lehigh Valley Hospital-Hazleton
-
Hershey, Pennsylvania, Spojené státy, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Lewisburg, Pennsylvania, Spojené státy, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, Spojené státy, 17044
- Lewistown Hospital
-
Monroeville, Pennsylvania, Spojené státy, 15146
- UPMC Hillman Cancer Center - Monroeville
-
Monroeville, Pennsylvania, Spojené státy, 15146
- UPMC Cancer Center - Monroeville
-
Philadelphia, Pennsylvania, Spojené státy, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, Spojené státy, 19114
- Jefferson Torresdale Hospital
-
Pittsburgh, Pennsylvania, Spojené státy, 15232
- UPMC Hillman Cancer Center
-
Pittsburgh, Pennsylvania, Spojené státy, 15232
- UPMC-Shadyside Hospital
-
Pittsburgh, Pennsylvania, Spojené státy, 15237
- UPMC-Passavant Hospital
-
Pittsburgh, Pennsylvania, Spojené státy, 15243
- UPMC-Saint Clair Hospital Cancer Center
-
Pottsville, Pennsylvania, Spojené státy, 17901
- Geisinger Cancer Services-Pottsville
-
Scranton, Pennsylvania, Spojené státy, 18510
- Community Medical Center
-
West Reading, Pennsylvania, Spojené státy, 19611
- Reading Hospital
-
Wilkes-Barre, Pennsylvania, Spojené státy, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Willow Grove, Pennsylvania, Spojené státy, 19090
- Asplundh Cancer Pavilion
-
-
South Carolina
-
Boiling Springs, South Carolina, Spojené státy, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Charleston, South Carolina, Spojené státy, 29425
- Medical University of South Carolina
-
Easley, South Carolina, Spojené státy, 29640
- Prisma Health Cancer Institute - Easley
-
Gaffney, South Carolina, Spojené státy, 29341
- Gibbs Cancer Center-Gaffney
-
Greenville, South Carolina, Spojené státy, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, Spojené státy, 29607
- Saint Francis Cancer Center
-
Greenville, South Carolina, Spojené státy, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, Spojené státy, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, Spojené státy, 29601
- Saint Francis Hospital
-
Greer, South Carolina, Spojené státy, 29650
- Prisma Health Cancer Institute - Greer
-
Greer, South Carolina, Spojené státy, 29651
- Gibbs Cancer Center-Pelham
-
Seneca, South Carolina, Spojené státy, 29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg, South Carolina, Spojené státy, 29303
- Spartanburg Medical Center
-
Union, South Carolina, Spojené státy, 29379
- SMC Center for Hematology Oncology Union
-
-
South Dakota
-
Aberdeen, South Dakota, Spojené státy, 57401
- Avera Cancer Institute-Aberdeen
-
Sioux Falls, South Dakota, Spojené státy, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, Spojené státy, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Spojené státy, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Nashville, Tennessee, Spojené státy, 37232
- Vanderbilt University/Ingram Cancer Center
-
-
Texas
-
Amarillo, Texas, Spojené státy, 79106
- The Don and Sybil Harrington Cancer Center
-
Austin, Texas, Spojené státy, 78712
- University of Texas at Austin
-
Austin, Texas, Spojené státy, 78701
- Dell Seton Medical Center at The University of Texas
-
Bryan, Texas, Spojené státy, 77802
- Saint Joseph Regional Cancer Center
-
Dallas, Texas, Spojené státy, 75235
- Parkland Memorial Hospital
-
Dallas, Texas, Spojené státy, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
Houston, Texas, Spojené státy, 77030
- Memorial Hermann Texas Medical Center
-
Humble, Texas, Spojené státy, 77338
- Memorial Hermann Northeast Hospital
-
-
Utah
-
American Fork, Utah, Spojené státy, 84003
- American Fork Hospital / Huntsman Intermountain Cancer Center
-
Cedar City, Utah, Spojené státy, 84720
- Sandra L Maxwell Cancer Center
-
Logan, Utah, Spojené státy, 84321
- Logan Regional Hospital
-
Murray, Utah, Spojené státy, 84107
- Intermountain Medical Center
-
Ogden, Utah, Spojené státy, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, Spojené státy, 84604
- Utah Valley Regional Medical Center
-
Riverton, Utah, Spojené státy, 84065
- Riverton Hospital
-
Salt Lake City, Utah, Spojené státy, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, Spojené státy, 84143
- LDS Hospital
-
St. George, Utah, Spojené státy, 84770
- Saint George Regional Medical Center
-
-
Vermont
-
Saint Johnsbury, Vermont, Spojené státy, 05819
- Dartmouth Cancer Center - North
-
-
Virginia
-
Richmond, Virginia, Spojené státy, 23235
- VCU Massey Cancer Center at Stony Point
-
Richmond, Virginia, Spojené státy, 23298
- VCU Massey Comprehensive Cancer Center
-
-
Washington
-
Aberdeen, Washington, Spojené státy, 98520
- Providence Regional Cancer System-Aberdeen
-
Auburn, Washington, Spojené státy, 98001
- MultiCare Auburn Medical Center
-
Bellevue, Washington, Spojené státy, 98004
- Overlake Medical Center
-
Bellingham, Washington, Spojené státy, 98225
- PeaceHealth Saint Joseph Medical Center
-
Burien, Washington, Spojené státy, 98166
- Saint Anne Hospital
-
Centralia, Washington, Spojené státy, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, Spojené státy, 98026
- Swedish Cancer Institute-Edmonds
-
Enumclaw, Washington, Spojené státy, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, Spojené státy, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, Spojené státy, 98003
- Saint Francis Hospital
-
Gig Harbor, Washington, Spojené státy, 98335
- MultiCare Gig Harbor Medical Park
-
Issaquah, Washington, Spojené státy, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, Spojené státy, 99336
- Kadlec Clinic Hematology and Oncology
-
Lacey, Washington, Spojené státy, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, Spojené státy, 98499
- Saint Clare Hospital
-
Longview, Washington, Spojené státy, 98632
- PeaceHealth Saint John Medical Center
-
Mount Vernon, Washington, Spojené státy, 98274
- Skagit Regional Health Cancer Care Center
-
Port Townsend, Washington, Spojené státy, 98368
- Jefferson Healthcare
-
Poulsbo, Washington, Spojené státy, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Puyallup, Washington, Spojené státy, 98372
- MultiCare Good Samaritan Hospital
-
Renton, Washington, Spojené státy, 98055
- Valley Medical Center
-
Seattle, Washington, Spojené státy, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, Spojené státy, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, Spojené státy, 98104
- Pacific Gynecology Specialists
-
Seattle, Washington, Spojené státy, 98122-5711
- Swedish Medical Center-Cherry Hill
-
Sedro-Woolley, Washington, Spojené státy, 98284
- PeaceHealth United General Medical Center
-
Shelton, Washington, Spojené státy, 98584
- Providence Regional Cancer System-Shelton
-
Silverdale, Washington, Spojené státy, 98383
- Saint Joseph Medical Center Hematology and Oncology - Silverdale
-
Spokane, Washington, Spojené státy, 99204
- MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
-
Spokane, Washington, Spojené státy, 99218
- MultiCare Deaconess Cancer and Blood Specialty Center - North
-
Spokane Valley, Washington, Spojené státy, 99216
- MultiCare Deaconess Cancer and Blood Specialty Center - Valley
-
Tacoma, Washington, Spojené státy, 98405
- Mary Bridge Children's Hospital and Health Center
-
Tacoma, Washington, Spojené státy, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, Spojené státy, 98405
- MultiCare Tacoma General Hospital
-
Tacoma, Washington, Spojené státy, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Vancouver, Washington, Spojené státy, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, Spojené státy, 99362
- Providence Saint Mary Regional Cancer Center
-
Yakima, Washington, Spojené státy, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
Yelm, Washington, Spojené státy, 98597
- Providence Regional Cancer System-Yelm
-
-
Wisconsin
-
Appleton, Wisconsin, Spojené státy, 54911
- ThedaCare Regional Cancer Center
-
Burlington, Wisconsin, Spojené státy, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Eau Claire, Wisconsin, Spojené státy, 54701
- Marshfield Medical Center-EC Cancer Center
-
Eau Claire, Wisconsin, Spojené státy, 54701
- HSHS Sacred Heart Hospital
-
Germantown, Wisconsin, Spojené státy, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, Spojené státy, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, Spojené státy, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, Spojené státy, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, Spojené státy, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Kenosha, Wisconsin, Spojené státy, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, Spojené státy, 54601
- Gundersen Lutheran Medical Center
-
Manitowoc, Wisconsin, Spojené státy, 54221
- Holy Family Memorial Hospital
-
Marinette, Wisconsin, Spojené státy, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marshfield, Wisconsin, Spojené státy, 54449
- Marshfield Medical Center-Marshfield
-
Menomonee Falls, Wisconsin, Spojené státy, 53051
- Froedtert Menomonee Falls Hospital
-
Milwaukee, Wisconsin, Spojené státy, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, Spojené státy, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, Spojené státy, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, Spojené státy, 53233
- Aurora Sinai Medical Center
-
Minocqua, Wisconsin, Spojené státy, 54548
- Marshfield Medical Center - Minocqua
-
Mukwonago, Wisconsin, Spojené státy, 53149
- ProHealth D N Greenwald Center
-
New Richmond, Wisconsin, Spojené státy, 54017
- Cancer Center of Western Wisconsin
-
Oak Creek, Wisconsin, Spojené státy, 53154
- Drexel Town Square Health Center
-
Oconomowoc, Wisconsin, Spojené státy, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oconto Falls, Wisconsin, Spojené státy, 54154
- Saint Vincent Hospital Cancer Center at Oconto Falls
-
Oshkosh, Wisconsin, Spojené státy, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, Spojené státy, 53406
- Aurora Cancer Care-Racine
-
Rice Lake, Wisconsin, Spojené státy, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, Spojené státy, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Sheboygan, Wisconsin, Spojené státy, 53081
- HSHS Saint Nicholas Hospital
-
Stevens Point, Wisconsin, Spojené státy, 54482
- Marshfield Medical Center-River Region at Stevens Point
-
Sturgeon Bay, Wisconsin, Spojené státy, 54235-1495
- Saint Vincent Hospital Cancer Center at Sturgeon Bay
-
Summit, Wisconsin, Spojené státy, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, Spojené státy, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, Spojené státy, 53188
- UW Cancer Center at ProHealth Care
-
Waukesha, Wisconsin, Spojené státy, 53188
- ProHealth Waukesha Memorial Hospital
-
Wauwatosa, Wisconsin, Spojené státy, 53226
- Aurora Cancer Care-Milwaukee West
-
West Allis, Wisconsin, Spojené státy, 53227
- Aurora West Allis Medical Center
-
West Bend, Wisconsin, Spojené státy, 53095
- Froedtert West Bend Hospital/Kraemer Cancer Center
-
Weston, Wisconsin, Spojené státy, 54476
- Marshfield Medical Center - Weston
-
-
Wyoming
-
Cheyenne, Wyoming, Spojené státy, 82001
- Cheyenne Regional Medical Center-West
-
Cody, Wyoming, Spojené státy, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, Spojené státy, 82801
- Welch Cancer Center
-
-
Kritéria účasti
Kritéria způsobilosti
Věk způsobilý ke studiu
Přijímá zdravé dobrovolníky
Pohlaví způsobilá ke studiu
Popis
Inclusion Criteria:
-
STEP 1: Age >= 18 years
-
STEP 1: Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
-
STEP 1: Patients must have oropharynx cancer (American Joint Committee on Cancer [AJCC] 8) that is p16-positive by immunohistochemistry OR p16 equivocal by IHC and HPV positive by in situ hybridization with the following criteria: >= 10 pack-years, stage T1-2N2-N3 or T3-4N0-3 (less than 10 pack-years is considered a non-smoker) OR < 10 pack-years, stage T4N0-N3 or T1-3N2-3
-
STEP 1: Patients must not have known hypersensitivity to nivolumab or compounds of similar chemical or biologic composition.
-
STEP 1: Patients with a history of allergic reactions attributed to platinum-based chemotherapy agents are excluded.
-
STEP 1: Patients must not have had prior systemic therapy, radiation treatment or surgery for p16 positive oropharyngeal squamous cell carcinoma (OPSCC).
- NOTE: Patients who had resection of T1 or T2 carcinoma with no radiation or chemotherapy are eligible if surgery was done 5 years prior to enrollment
-
STEP 1: Patients must not have received previous irradiation for head and neck tumor, skull base, or brain tumors.
-
STEP 1: Patients must not receive investigational agents within 4 weeks of enrollment or at any time while on study.
-
STEP 1: Patients with evidence of distant metastases or leptomeningeal disease (LMD) are excluded.
-
STEP 1: Patients with uncontrolled inter-current illnesses which in the opinion of the investigator will interfere with the ability to undergo therapy including chemotherapy are excluded.
-
STEP 1: Patients with a history of prior or second malignancy are excluded, with the exception of curatively treated non-melanoma skin cancer, or curatively treated cervical cancer; additionally, patients curatively treated for malignancy who remain disease-free at > 2 years of follow up, are not excluded.
-
STEP 1: Absolute neutrophil count (ANC) >= 1500/mm^3 (must be obtained =< 2 weeks prior to randomization).
-
STEP 1: Hemoglobin (Hgb) >= 8.0 g/dL (must be obtained =< 2 weeks prior to randomization).
-
STEP 1: Platelet count >= 100,000/mm^3 (must be obtained =< 2 weeks prior to randomization).
-
STEP 1: Creatinine clearance of >= 60 ml/min (must be obtained =< 2 weeks prior to randomization). Creatinine clearance may be measured or calculated. If calculating, creatinine clearance, use the Cockcroft-Gault formula.
-
STEP 1: Total bilirubin within 1.5 times the normal limits (must be obtained =< 2 weeks prior to randomization).
-
STEP 1: Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) or serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) within 2.0 times the normal limits (must be obtained =< 2 weeks prior to randomization).
-
STEP 1: Alkaline phosphatase within 2.0 times the normal limits (must be obtained =< 2 weeks prior to randomization).
-
STEP 1: Patients must not be pregnant or breast-feeding as chemotherapy, radiation, and immunotherapy may have possible teratogenicity effects; in addition, complications from pregnancy may interfere with the ability of patients to have an uninterrupted therapy. All patients of childbearing potential must have a blood test or urine study within 2 weeks prior to randomization to rule out pregnancy. A patient of childbearing potential is any patient, regardless of whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months).
-
STEP 1: Patients of childbearing potential must use an accepted and effective method of contraception or abstain from sexual intercourse for at least one week prior to the start of treatment, and continue for 5 months after the last dose of protocol treatment. Patients must also not donate ova during this same time period.
-
STEP 1: Patients must have measurable disease
-
STEP 1: Patients must have tumor measurements with CT of neck and CT of chest (or CT of neck and FDG PET/CT if standard of care) within 4 weeks prior to Step 1 randomization.
-
STEP 1: Patients with active autoimmune disease or history of autoimmune disease that might recur, which may affect vital organ function or require immune suppressive treatment including systemic corticosteroids, should be excluded. These include but are not limited to patients with a history of immune related neurologic disease, multiple sclerosis, autoimmune (demyelinating) neuropathy, Guillain-Barre syndrome, myasthenia gravis; systemic autoimmune disease such as systemic lupus erythematosus (SLE), connective tissue disease, scleroderma, inflammatory bowel disease (IBD), Crohn's, ulcerative colitis, hepatitis; and patients with a history of toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome, or phospholipid syndrome should be excluded because of the risk of recurrence or exacerbation of disease. Patients with vitiligo, endocrine deficiencies including thyroiditis managed with replacement hormones including physiologic corticosteroids are eligible. Patients with rheumatoid arthritis and other arthropathies, Sjogren's syndrome and psoriasis controlled with topical medication and patients with positive serology, such as antinuclear antibodies (ANA), anti-thyroid antibodies should be evaluated for the presence of target organ involvement and potential need for systemic treatment but should otherwise be eligible.
-
STEP 1: Patients are permitted to enroll if they have vitiligo, type I diabetes mellitus, residual hypothyroidism due to autoimmune condition only requiring hormone replacement, psoriasis not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger (precipitating event).
-
STEP 1: Patients must not have a condition requiring systemic treatment with either corticosteroids (> 10 mg/day prednisone equivalents) or other immunosuppressive medications which are expected to continue during nivolumab administration. Inhaled or topical steroids and adrenal replacement doses > 10 mg/day prednisone equivalents are permitted in the absence of active autoimmune disease
-
STEP 1: Patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated
-
STEP 1: Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load
-
STEP 1: Patients with a known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) must have no detectable viral load on a stable antiviral regimen
-
STEP 1: Patients must not be receiving any other investigational agents.
-
STEP 1: Patient must not have a baseline clinically significant hearing loss, which in the opinion of the investigator would preclude the use of cisplatin
-
STEP 2: Patients must have progression per RECIST criteria AND tissue-proven progression on Arm B treatment within 12 months after completion of radiation therapy.
-
STEP 2: ECOG performance status of 0 or 1.
-
STEP 2: Patients must not have known hypersensitivity to nivolumab or compounds of similar chemical or biologic composition.
-
STEP 2: Patients must not have received non-protocol anti-cancer therapy after completion of radiation and chemotherapy.
-
STEP 2: ANC >= 1500/mm^3 (must be obtained =< 2 weeks prior to registration).
-
STEP 2: Hgb >= 8.0 g/dL (must be obtained =< 2 weeks prior to registration).
-
STEP 2: Platelet count >= 100,000/mm^3 (must be obtained =< 2 weeks prior to registration).
-
STEP 2: Creatinine within institutional limits of normal (must be obtained =< 2 weeks prior to registration)
-
STEP 2: Total bilirubin within 1.5 times the normal limits (must be obtained =< 2 weeks prior to registration).
-
STEP 2: SGOT (AST) or SGPT (ALT) within 2.0 times the normal limits (must be obtained =< 2 weeks prior to registration).
-
STEP 2: Alkaline phosphatase within 1.5 times the normal limits (must be obtained =< 2 weeks prior to registration).
-
STEP 2: Patients must not be pregnant or breast-feeding as chemotherapy, radiation, and immunotherapy may have possible teratogenicity effects; in addition, complications from pregnancy may interfere with the ability of patients to have an uninterrupted therapy. All patients of childbearing potential must have a blood test or urine study within 2 weeks prior to registration to rule out pregnancy. A patient of childbearing potential is any patient, regardless of whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months).
-
STEP 2: Patients of childbearing potential must use an accepted and effective method of contraception or abstain from sexual intercourse for at least one week prior to the start of treatment, and continue for 5 months after the last dose of protocol treatment. Patients must also not donate ova during this same time period.
-
STEP 2: Patients must have measurable disease at the time of documented progression
- NOTE: For patients that have undergone salvage surgery for disease recurrence, measurable disease is not required at the time of registration to Step 2
-
STEP 2: Patients must have tumor measurements with CT of neck and CT of chest (or CT of neck and FDG PET/CT if standard of care) within 4 weeks prior to Step 2 registration
- NOTE: Patients that have undergone salvage surgery for disease recurrence prior to Step 2 are not required to have measurable disease post-resection, but must have CT of neck and CT of chest (or CT of neck and FDG PET/CT if standard of care) after salvage surgery and within 4 weeks prior to step 2 registration to establish a baseline prior to nivolumab
Studijní plán
Jak je studie koncipována?
Detaily designu
- Primární účel: Léčba
- Přidělení: Randomizované
- Intervenční model: Crossover Assignment
- Maskování: Žádné (otevřený štítek)
Zbraně a zásahy
Skupina účastníků / Arm |
Intervence / Léčba |
|---|---|
|
Experimentální: Arm A (cisplatin, IMRT, nivolumab)
Patients receive cisplatin IV over 60 minutes weekly and IMRT 5 days a week for 7 weeks for a total of 35 fractions. Within 4 weeks after completion of concurrent therapy, patients receive nivolumab IV once weekly over 30 minutes every 4 weeks for 12 months in the absence of disease progression or unacceptable toxicity. Patients undergo CT or FDG PET/CT scans throughout the trial. Patients may undergo ECHO as clinically indicated. Additionally, patients undergo blood sample collection during screening. |
Given IV
Ostatní jména:
Undergo blood sample collection
Ostatní jména:
Undergo ECHO
Ostatní jména:
Given IV
Ostatní jména:
Undergo CT or PET/CT
Ostatní jména:
Undergo PET/CT
Ostatní jména:
Undergo IMRT
Ostatní jména:
Receive FDG
Ostatní jména:
|
|
Aktivní komparátor: Arm B (cisplatin, IMRT, observation)
Patients receive cisplatin IV over 60 minutes weekly and IMRT 5 days a week for 7 weeks for a total of 35 fractions, and then go on observation. Patients will be offered the option to cross-over to Arm C if they have clearly documented progression within 12 months from the end of cisplatin/radiation therapy. Patients undergo CT or FDG PET/CT scans throughout the trial. Patients may undergo ECHO as clinically indicated. Additionally, patients undergo blood sample collection during screening. |
Given IV
Ostatní jména:
Undergo blood sample collection
Ostatní jména:
Undergo ECHO
Ostatní jména:
Undergo CT or PET/CT
Ostatní jména:
Undergo PET/CT
Ostatní jména:
Undergo IMRT
Ostatní jména:
Undergo observation
Ostatní jména:
Receive FDG
Ostatní jména:
|
|
Experimentální: Arm C (nivolumab)
Patients receive nivolumab IV over 30 minutes every 4 weeks for 12 months in the absence of disease progression or unacceptable toxicity. Patients undergo CT or FDG PET/CT scans throughout the trial. Patients may undergo ECHO as clinically indicated. Additionally, patients undergo blood sample collection during screening. |
Undergo blood sample collection
Ostatní jména:
Undergo ECHO
Ostatní jména:
Given IV
Ostatní jména:
Undergo CT or PET/CT
Ostatní jména:
Undergo PET/CT
Ostatní jména:
Receive FDG
Ostatní jména:
|
Co je měření studie?
Primární výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
|---|---|---|
|
Overall survival (OS)
Časové okno: From randomization to death, assessed up to 10 years
|
Log rank test will be used to compare OS. As patients on the observation arm are allowed to cross-over to the nivolumab arm upon progression, an overall survival analysis using inverse probability censoring weights (IPCW, Robins et. al, 2000) will also be considered. Kaplan-Meier method and Cox regression will be used for the survival outcome analyses. |
From randomization to death, assessed up to 10 years
|
|
Negative (standardized qualitative) 12 week post therapy (cisplatin + radiation therapy [RT]) FDG positron emission tomography/computed tomography (PET/CT) associated with OS for patients who have a PET/CT
Časové okno: At 12 weeks post therapy
|
Logrank tests and input hazard rates will be used. |
At 12 weeks post therapy
|
|
Negative (standardized qualitative) 12 week post therapy (cisplatin + RT) FDG PET/CT associated with PFS for patients who have a PET/CT
Časové okno: At 12 weeks post therapy
|
Logrank tests and input hazard rates will be used. |
At 12 weeks post therapy
|
Sekundární výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
|---|---|---|
|
Progression-free survival (PFS)
Časové okno: From randomization to date of progression, second primary tumor from the head and neck region, or death, assessed up to 10 years
|
Progression will be defined using Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria. The comparison of PFS will use stratified log rank test and will be intent-to-treat analyses. |
From randomization to date of progression, second primary tumor from the head and neck region, or death, assessed up to 10 years
|
|
Prognostic effect of baseline PD-L1 expression (positive versus [vs.] negative) on OS and PFS
Časové okno: Baseline up to 10 years
|
Chi-square testing or Pearson correlation testing will be used for the secondary correlation analyses. |
Baseline up to 10 years
|
|
Prognostic effect of baseline saliva and/or plasma human papillomavirus (HPV) status (positive vs. negative) on OS and PFS
Časové okno: Baseline up to 10 years
|
Saliva and plasma HPV status at 12 weeks and 9 months following completion of concurrent therapy will also be analyzed regarding effect on outcome. Chi-square testing or Pearson correlation testing will be used for the secondary correlation analyses. |
Baseline up to 10 years
|
|
Prognostic value of maximum standardized uptake value (SUVmax) of primary tumor or neck nodal metastasis of baseline FDG PET/CT for OS
Časové okno: Baseline up to 10 years
|
Chi-square testing or Pearson correlation testing will be used for the secondary correlation analyses. |
Baseline up to 10 years
|
|
Prognostic value of SUVmax of primary tumor or neck nodal metastasis of baseline FDG PET/CT for PFS
Časové okno: Baseline up to 10 years
|
Chi-square testing or Pearson correlation testing will be used for the secondary correlation analyses. |
Baseline up to 10 years
|
|
SUVmax of primary tumor or nodal metastasis of baseline FDG PET/CT with PD-L1 expression (positive vs. negative)
Časové okno: Baseline up to 10 years
|
Chi-square testing or Pearson correlation testing will be used for the secondary correlation analyses. |
Baseline up to 10 years
|
|
Post therapy (cisplatin + RT) FDG PET/CT with saliva or plasma levels of HPV deoxyribonucleic acid (DNA)
Časové okno: Up to 9 months post-therapy
|
Chi-square testing or Pearson correlation testing will be used for the secondary correlation analyses. |
Up to 9 months post-therapy
|
|
PET based therapy response assessment compared to RECIST 1.1 assessment for patients who have a PET/CT scan at 12 weeks
Časové okno: At 12 weeks post chemoradiation therapy
|
Kappa statistics will be applied to evaluate the agreement between PET based therapy response assessment (Hopkins criteria) and RECIST 1.1 assessment at 12 weeks post chemoradiation therapy. |
At 12 weeks post chemoradiation therapy
|
Spolupracovníci a vyšetřovatelé
Sponzor
Vyšetřovatelé
- Vrchní vyšetřovatel: Nabil F Saba, ECOG-ACRIN Cancer Research Group
Termíny studijních záznamů
Hlavní termíny studia
Začátek studia (Aktuální)
Primární dokončení (Odhadovaný)
Dokončení studie (Odhadovaný)
Termíny zápisu do studia
První předloženo
První předloženo, které splnilo kritéria kontroly kvality
První zveřejněno (Aktuální)
Aktualizace studijních záznamů
Poslední zveřejněná aktualizace (Aktuální)
Odeslaná poslední aktualizace, která splnila kritéria kontroly kvality
Naposledy ověřeno
Více informací
Termíny související s touto studií
Další relevantní podmínky MeSH
- Stomatognátní onemocnění
- Novotvary podle místa
- Novotvary
- Novotvary hlavy a krku
- Otorinolaryngologická onemocnění
- Novotvary hltanu
- Otorinolaryngologické novotvary
- Faryngeální onemocnění
- Orofaryngeální novotvary
- Správa zdravotnických služeb
- Aminokyseliny, peptidy a proteiny
- Proteiny
- Vyšetřovací techniky
- Metody
- Terapeutika
- Klinické laboratorní techniky
- Diagnostické techniky a postupy
- Diagnóza
- Kvalita zdravotní péče
- Uhlohydráty
- Protilátky, monoklonální, humanizované
- Protilátky, monoklonální
- Protilátky
- Imunoglobuliny
- Imunoproteiny
- Krevní proteiny
- Sérové globuliny
- Globuliny
- Anorganické chemikálie
- Sloučeniny chloru
- Sloučeniny dusíku
- Prvky
- Kovy
- Techniky chemie, analytické
- Analýza spektra
- Kovy, těžké
- Platinové sloučeniny
- Radioterapie
- Deoxyglukóza
- Deoxy cukry
- Posouzení výsledku, zdravotní péče
- Výsledek a posouzení procesů, zdravotní péče
- Přechodové prvky
- Radioterapie, konformní
- Radioterapie, asistovaná počítačem
- Nivolumab
- Fluordeoxyglukóza F18
- Cisplatina
- 1,2-diaminocyklohexanplatina II citrát
- Pozorování
- Manipulace se vzorkem
- Magnetická rezonanční spektroskopie
- Ostražité čekání
- Platina
- Radioterapie, modulovaná intenzita
Další identifikační čísla studie
- NCI-2019-00179
- U10CA180820 (Grant/smlouva NIH USA)
- NCI-2019-00179 (Identifikátor registru: CTRP (Clinical Trial Reporting Program))
- EA3161 (Jiný identifikátor: CTEP)
- EA3161 (Jiný identifikátor: ECOG-ACRIN Cancer Research Group)
Plán pro data jednotlivých účastníků (IPD)
Plánujete sdílet data jednotlivých účastníků (IPD)?
Popis plánu IPD
NCI is committed to sharing data in accordance with NIH policy. For more details on how clinical trial data is shared, access the link to the NIH data sharing policy page
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