Test dell'immunoterapia rispetto all'osservazione nei pazienti con cancro alla gola HPV
Uno studio randomizzato di fase III sul mantenimento con nivolumab rispetto all'osservazione in pazienti con OPSCC HPV positivo a rischio intermedio e localmente avanzato
This phase III trials studies whether maintenance immunotherapy (nivolumab) following definitive treatment with radiation and chemotherapy (cisplatin) result in significant improvement in overall survival (time being alive) and progression-free survival (time being alive without cancer) for patients with intermediate risk human papillomavirus (HPV) positive oropharynx cancer (throat cancer) that has spread to nearby tissue or lymph nodes. Drugs used in chemotherapy such as cisplatin work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy rays to kill tumor cells and shrink tumors. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. It is not yet known whether chemotherapy and radiation therapy followed by maintenance nivolumab therapy works better than chemotherapy and radiation therapy alone in treating patients with HPV positive oropharyngeal cancer.
Panoramica dello studio
Stato
Condizioni
Intervento / Trattamento
Descrizione dettagliata
PRIMARY OBJECTIVE:
I. To assess the efficacy of concurrent definitive therapy followed by nivolumab compared with concurrent definitive therapy followed by observation in terms of overall survival (OS).
SECONDARY OBJECTIVES:
I. To further assess the efficacy of nivolumab compared with observation in terms of:
Ia. To evaluate treatment effect within the subset of patients tested as PD-L1+ .
Ib. To evaluate the prognostic effect of baseline saliva and/or plasma HPV status .
Ic. To evaluate the prognostic effect of mutation burden among patients on the nivolumab arm.
Id. To evaluate the association of 12-week post therapy fludeoxyglucose F-18 (FDG) positron emission tomography(PET)/computed tomography (CT) OS and progression free survival (PFS).
Ie. To establish the prognostic value of standardized uptake value (SUV) max of primary tumor or neck nodal metastasis of baseline FDG PET/CT for OS (and/or PFS).
If. To correlate SUV max of primary tumor or nodal metastasis of baseline FDG PET/CT with PD-L1 expression (positive versus [vs.] negative).
Ig. To compare the PET based therapy response assessment (Hopkins criteria) to the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 assessment at 12 week post chemoradiation therapy, for patients who have a PET/CT scan at 12 weeks.
II. To assess the efficacy of concurrent definitive therapy followed by nivolumab in terms of progression free survival (PFS).
OUTLINE: Patients are randomized to Arm A or Arm B. Patients in Arm B may cross-over to Arm C with clearly documented disease progression.
ARM A: Patients receive cisplatin intravenously (IV) over 60 minutes weekly and intensity modulated radiation therapy (IMRT) 5 days a week for 7 weeks for a total of 35 fractions. Within 4 weeks after completion of concurrent therapy, patients receive nivolumab IV once weekly over 30 minutes every 4 weeks for 12 months in the absence of disease progression or unacceptable toxicity.
ARM B: Patients receive cisplatin IV over 60 minutes weekly and IMRT 5 days a week for 7 weeks for a total of 35 fractions, and then go on observation. Patients will be offered the option to cross-over to Arm C if they have clearly documented progression within 12 months from the end of cisplatin/radiation therapy.
ARM C: Patients receive nivolumab IV over 30 minutes every 4 weeks for 12 months in the absence of disease progression or unacceptable toxicity.
All patients undergo computed tomography (CT) or Fludeoxyglucose F-18 (FDG) positron emission tomography (PET)/CT scans throughout the trial. Patients may undergo echocardiography (ECHO) as clinically indicated. Additionally, patients undergo blood sample collection during screening.
After completion of study treatment, patients are followed up every 3-6 months for 3 years and then annually for a total of 10 years.
Tipo di studio
Iscrizione (Stimato)
Fase
- Fase 3
Contatti e Sedi
Luoghi di studio
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Alabama
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Fairhope, Alabama, Stati Uniti, 36532
- Thomas Hospital
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Mobile, Alabama, Stati Uniti, 36607
- Mobile Infirmary Medical Center
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Alaska
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Anchorage, Alaska, Stati Uniti, 98508
- Anchorage Associates in Radiation Medicine
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Anchorage, Alaska, Stati Uniti, 99508
- Alaska Breast Care and Surgery LLC
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Anchorage, Alaska, Stati Uniti, 99508
- Alaska Oncology and Hematology LLC
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Anchorage, Alaska, Stati Uniti, 99508
- Alaska Women's Cancer Care
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Anchorage, Alaska, Stati Uniti, 99508
- Anchorage Oncology Centre
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Anchorage, Alaska, Stati Uniti, 99508
- Katmai Oncology Group
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Anchorage, Alaska, Stati Uniti, 99508
- Providence Alaska Medical Center
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Anchorage, Alaska, Stati Uniti, 99504
- Anchorage Radiation Therapy Center
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Fairbanks, Alaska, Stati Uniti, 99701
- Fairbanks Memorial Hospital
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Arizona
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Goodyear, Arizona, Stati Uniti, 85338
- CTCA at Western Regional Medical Center
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Kingman, Arizona, Stati Uniti, 86401
- Kingman Regional Medical Center
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Phoenix, Arizona, Stati Uniti, 85004
- Cancer Center at Saint Joseph's
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Arkansas
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Fort Smith, Arkansas, Stati Uniti, 72903
- Mercy Hospital Fort Smith
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Hot Springs, Arkansas, Stati Uniti, 71913
- CHI Saint Vincent Cancer Center Hot Springs
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California
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Antioch, California, Stati Uniti, 94531
- Kaiser Permanente-Deer Valley Medical Center
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Arroyo Grande, California, Stati Uniti, 93420
- PCR Oncology
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Arroyo Grande, California, Stati Uniti, 93420
- Mission Hope Medical Oncology - Arroyo Grande
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Burbank, California, Stati Uniti, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Carmichael, California, Stati Uniti, 95608
- Mercy San Juan Medical Center
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Carmichael, California, Stati Uniti, 95608
- Mercy Cancer Center - Carmichael
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Dublin, California, Stati Uniti, 94568
- Kaiser Permanente Dublin
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Dublin, California, Stati Uniti, 94568
- Epic Care-Dublin
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Elk Grove, California, Stati Uniti, 95758
- Mercy Cancer Center - Elk Grove
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Emeryville, California, Stati Uniti, 94608
- Bay Area Breast Surgeons Inc
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Emeryville, California, Stati Uniti, 94608
- Epic Care Partners in Cancer Care
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Fremont, California, Stati Uniti, 94538
- Kaiser Permanente-Fremont
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Fresno, California, Stati Uniti, 93720
- Kaiser Permanente-Fresno
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Fresno, California, Stati Uniti, 93720
- Fresno Cancer Center
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Long Beach, California, Stati Uniti, 90822
- Tibor Rubin VA Medical Center
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Martinez, California, Stati Uniti, 94553-3156
- Contra Costa Regional Medical Center
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Merced, California, Stati Uniti, 95340
- Mercy Cancer Center
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Modesto, California, Stati Uniti, 95356
- Kaiser Permanente-Modesto
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Napa, California, Stati Uniti, 94558
- Providence Queen of The Valley
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Oakland, California, Stati Uniti, 94611
- Kaiser Permanente-Oakland
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Oakland, California, Stati Uniti, 94611
- Kaiser Permanente Oakland-Broadway
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Oakland, California, Stati Uniti, 94609
- Alta Bates Summit Medical Center - Summit Campus
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Oakland, California, Stati Uniti, 94609
- Bay Area Tumor Institute
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Palo Alto, California, Stati Uniti, 94304
- VA Palo Alto Health Care System
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Rancho Cordova, California, Stati Uniti, 95670
- Kaiser Permanente-Rancho Cordova Cancer Center
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Redwood City, California, Stati Uniti, 94063
- Kaiser Permanente-Redwood City
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Richmond, California, Stati Uniti, 94801
- Kaiser Permanente-Richmond
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Rocklin, California, Stati Uniti, 95765
- Mercy Cancer Center - Rocklin
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Rohnert Park, California, Stati Uniti, 94928
- Rohnert Park Cancer Center
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Roseville, California, Stati Uniti, 95678
- The Permanente Medical Group-Roseville Radiation Oncology
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Roseville, California, Stati Uniti, 95661
- Kaiser Permanente-Roseville
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Sacramento, California, Stati Uniti, 95814
- Kaiser Permanente Downtown Commons
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Sacramento, California, Stati Uniti, 95823
- South Sacramento Cancer Center
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Sacramento, California, Stati Uniti, 95816
- Mercy Cancer Center - Sacramento
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Salinas, California, Stati Uniti, 93901
- Salinas Valley Memorial
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San Diego, California, Stati Uniti, 92134
- Naval Medical Center -San Diego
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San Diego, California, Stati Uniti, 92103
- UC San Diego Medical Center - Hillcrest
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San Francisco, California, Stati Uniti, 94115
- Kaiser Permanente-San Francisco
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San Jose, California, Stati Uniti, 95119
- Kaiser Permanente-Santa Teresa-San Jose
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San Leandro, California, Stati Uniti, 94577
- Kaiser Permanente San Leandro
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San Luis Obispo, California, Stati Uniti, 93401
- Pacific Central Coast Health Center-San Luis Obispo
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San Rafael, California, Stati Uniti, 94903
- Kaiser San Rafael-Gallinas
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Santa Clara, California, Stati Uniti, 95051
- Kaiser Permanente Medical Center - Santa Clara
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Santa Maria, California, Stati Uniti, 93444
- Mission Hope Medical Oncology - Santa Maria
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Santa Rosa, California, Stati Uniti, 95403
- Kaiser Permanente-Santa Rosa
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Santa Rosa, California, Stati Uniti, 95403
- Providence Medical Foundation - Santa Rosa
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South San Francisco, California, Stati Uniti, 94080
- Kaiser Permanente Cancer Treatment Center
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South San Francisco, California, Stati Uniti, 94080
- Kaiser Permanente-South San Francisco
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Stockton, California, Stati Uniti, 95210
- Kaiser Permanente-Stockton
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Vacaville, California, Stati Uniti, 95688
- Kaiser Permanente Medical Center-Vacaville
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Vallejo, California, Stati Uniti, 94589
- Kaiser Permanente-Vallejo
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Walnut Creek, California, Stati Uniti, 94596
- Kaiser Permanente-Walnut Creek
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Walnut Creek, California, Stati Uniti, 94597
- Epic Care Cyberknife Center
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Woodland, California, Stati Uniti, 95695
- Woodland Memorial Hospital
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Colorado
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Aurora, Colorado, Stati Uniti, 80012
- Rocky Mountain Cancer Centers-Aurora
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Aurora, Colorado, Stati Uniti, 80012
- The Medical Center of Aurora
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Aurora, Colorado, Stati Uniti, 80045
- UCHealth University of Colorado Hospital
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Boulder, Colorado, Stati Uniti, 80303
- Boulder Community Foothills Hospital
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Boulder, Colorado, Stati Uniti, 80304
- Rocky Mountain Cancer Centers-Boulder
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Centennial, Colorado, Stati Uniti, 80112
- Rocky Mountain Cancer Centers - Centennial
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Colorado Springs, Colorado, Stati Uniti, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, Stati Uniti, 80909
- UCHealth Memorial Hospital Central
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Colorado Springs, Colorado, Stati Uniti, 80907
- Rocky Mountain Cancer Centers-Penrose
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Colorado Springs, Colorado, Stati Uniti, 80920
- Memorial Hospital North
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Colorado Springs, Colorado, Stati Uniti, 80923
- Saint Francis Cancer Center
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Denver, Colorado, Stati Uniti, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, Stati Uniti, 80220
- Rose Medical Center
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Denver, Colorado, Stati Uniti, 80218
- Rocky Mountain Cancer Centers-Midtown
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Denver, Colorado, Stati Uniti, 80220
- Rocky Mountain Cancer Centers-Rose
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Denver, Colorado, Stati Uniti, 80218
- Colorado Blood Cancer Institute
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Denver, Colorado, Stati Uniti, 80204
- Cancer Center of Colorado at Sloan's Lake
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Denver, Colorado, Stati Uniti, 80209
- The Women's Imaging Center
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Denver, Colorado, Stati Uniti, 80206
- National Jewish Health-Main Campus
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Denver, Colorado, Stati Uniti, 80220
- Western Surgical Care
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Denver, Colorado, Stati Uniti, 80218
- Saint Joseph Hospital - Cancer Centers of Colorado
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Denver, Colorado, Stati Uniti, 80210
- AdventHealth Porter
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Durango, Colorado, Stati Uniti, 81301
- Mercy Medical Center
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Durango, Colorado, Stati Uniti, 81301
- CommonSpirit Cancer Center Mercy
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Englewood, Colorado, Stati Uniti, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, Stati Uniti, 80113
- Swedish Medical Center
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Englewood, Colorado, Stati Uniti, 80113
- Rocky Mountain Cancer Centers - Swedish
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Englewood, Colorado, Stati Uniti, 80113
- The Melanoma and Skin Cancer Institute
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Fort Collins, Colorado, Stati Uniti, 80524
- Poudre Valley Hospital
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Fort Collins, Colorado, Stati Uniti, 80528
- Cancer Care and Hematology-Fort Collins
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Golden, Colorado, Stati Uniti, 80401
- National Jewish Health-Western Hematology Oncology
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Grand Junction, Colorado, Stati Uniti, 81501
- Saint Mary's Hospital and Regional Medical Center
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Greeley, Colorado, Stati Uniti, 80631
- UCHealth Greeley Hospital
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Greeley, Colorado, Stati Uniti, 80631
- Banner North Colorado Medical Center
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Lafayette, Colorado, Stati Uniti, 80026
- Good Samaritan Hospital - Cancer Centers of Colorado
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Lakewood, Colorado, Stati Uniti, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Lakewood, Colorado, Stati Uniti, 80228
- CommonSpirit Saint Anthony Hospital Cancer Center
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Littleton, Colorado, Stati Uniti, 80120
- Rocky Mountain Cancer Centers-Littleton
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Littleton, Colorado, Stati Uniti, 80122
- AdventHealth Littleton
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Lone Tree, Colorado, Stati Uniti, 80124
- Sky Ridge Medical Center
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Lone Tree, Colorado, Stati Uniti, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
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Longmont, Colorado, Stati Uniti, 80501
- Longmont United Hospital
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Longmont, Colorado, Stati Uniti, 80501
- Rocky Mountain Cancer Centers-Longmont
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Loveland, Colorado, Stati Uniti, 80538
- Medical Center of the Rockies
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Loveland, Colorado, Stati Uniti, 80539
- Banner North Colorado Medical Center - Loveland Campus
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Parker, Colorado, Stati Uniti, 80138
- AdventHealth Parker
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Pueblo, Colorado, Stati Uniti, 81004
- Saint Mary Corwin Medical Center
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Thornton, Colorado, Stati Uniti, 80260
- Rocky Mountain Cancer Centers-Thornton
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Thornton, Colorado, Stati Uniti, 80260
- National Jewish Health-Northern Hematology Oncology
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Wheat Ridge, Colorado, Stati Uniti, 80401
- Intermountain Health Lutheran Hospital
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Connecticut
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Greenwich, Connecticut, Stati Uniti, 06830
- Smilow Cancer Hospital Care Center at Greenwich
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Guilford, Connecticut, Stati Uniti, 06437
- Smilow Cancer Hospital Care Center - Guilford
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New Haven, Connecticut, Stati Uniti, 06520
- Yale University
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New Haven, Connecticut, Stati Uniti, 06510
- Smilow Cancer Center/Yale-New Haven Hospital
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North Haven, Connecticut, Stati Uniti, 06473
- Yale-New Haven Hospital North Haven Medical Center
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Orange, Connecticut, Stati Uniti, 06477
- Smilow Cancer Hospital-Orange Care Center
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Trumbull, Connecticut, Stati Uniti, 06611
- Smilow Cancer Hospital Care Center-Trumbull
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Waterford, Connecticut, Stati Uniti, 06385
- Smilow Cancer Hospital Care Center - Waterford
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Delaware
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Lewes, Delaware, Stati Uniti, 19958
- Beebe Medical Center
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Millville, Delaware, Stati Uniti, 19967
- Beebe South Coastal Health Campus
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Newark, Delaware, Stati Uniti, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, Stati Uniti, 19713
- Delaware Clinical and Laboratory Physicians PA
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Newark, Delaware, Stati Uniti, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, Stati Uniti, 19718
- Christiana Care Health System-Christiana Hospital
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Rehoboth Beach, Delaware, Stati Uniti, 19971
- Beebe Health Campus
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District of Columbia
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Washington D.C., District of Columbia, Stati Uniti, 20037
- George Washington University Medical Center
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Florida
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Deerfield Beach, Florida, Stati Uniti, 33064
- Broward Health North
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Fort Lauderdale, Florida, Stati Uniti, 33316
- Broward Health Medical Center
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Fort Lauderdale, Florida, Stati Uniti, 33308
- Holy Cross Hospital
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Lakeland, Florida, Stati Uniti, 33805
- The Watson Clinic
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Tampa, Florida, Stati Uniti, 33612
- Moffitt Cancer Center
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Tampa, Florida, Stati Uniti, 33607
- Moffitt Cancer Center-International Plaza
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Tampa, Florida, Stati Uniti, 33612
- Moffitt Cancer Center - McKinley Campus
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Wesley Chapel, Florida, Stati Uniti, 33544
- Moffitt Cancer Center at Wesley Chapel
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Georgia
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Atlanta, Georgia, Stati Uniti, 30308
- Emory University Hospital Midtown
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Atlanta, Georgia, Stati Uniti, 30322
- Emory University Hospital/Winship Cancer Institute
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Decatur, Georgia, Stati Uniti, 30033
- Atlanta VA Medical Center
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Savannah, Georgia, Stati Uniti, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Valdosta, Georgia, Stati Uniti, 31602
- South Georgia Medical Center/Pearlman Cancer Center
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Hawaii
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Honolulu, Hawaii, Stati Uniti, 96813
- Queen's Medical Center
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Honolulu, Hawaii, Stati Uniti, 96817
- The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, Stati Uniti, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, Stati Uniti, 96813
- Queen's Cancer Cenrer - POB I
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Honolulu, Hawaii, Stati Uniti, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, Stati Uniti, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, Stati Uniti, 96817
- Kuakini Medical Center
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Honolulu, Hawaii, Stati Uniti, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, Stati Uniti, 96826
- Kapiolani Medical Center for Women and Children
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Honolulu, Hawaii, Stati Uniti, 96819
- Kaiser Permanente Moanalua Medical Center
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Lihue, Hawaii, Stati Uniti, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
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‘Aiea, Hawaii, Stati Uniti, 96701
- Hawaii Cancer Care - Westridge
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‘Aiea, Hawaii, Stati Uniti, 96701
- Pali Momi Medical Center
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‘Aiea, Hawaii, Stati Uniti, 96701
- Queen's Cancer Center - Pearlridge
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‘Aiea, Hawaii, Stati Uniti, 96701
- The Cancer Center of Hawaii-Pali Momi
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Idaho
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Boise, Idaho, Stati Uniti, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Boise, Idaho, Stati Uniti, 83712
- Saint Luke's Cancer Institute - Boise
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Caldwell, Idaho, Stati Uniti, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
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Coeur d'Alene, Idaho, Stati Uniti, 83814
- Kootenai Health - Coeur d'Alene
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Emmett, Idaho, Stati Uniti, 83617
- Walter Knox Memorial Hospital
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Fruitland, Idaho, Stati Uniti, 83619
- Saint Luke's Cancer Institute - Fruitland
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Meridian, Idaho, Stati Uniti, 83642
- Idaho Urologic Institute-Meridian
-
Meridian, Idaho, Stati Uniti, 83642
- Saint Luke's Cancer Institute - Meridian
-
Nampa, Idaho, Stati Uniti, 83687
- Saint Alphonsus Cancer Care Center-Nampa
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Nampa, Idaho, Stati Uniti, 83687
- Saint Luke's Cancer Institute - Nampa
-
Post Falls, Idaho, Stati Uniti, 83854
- Kootenai Clinic Cancer Services - Post Falls
-
Sandpoint, Idaho, Stati Uniti, 83864
- Kootenai Clinic Cancer Services - Sandpoint
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Twin Falls, Idaho, Stati Uniti, 83301
- Saint Luke's Cancer Institute - Twin Falls
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Illinois
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Alton, Illinois, Stati Uniti, 62002
- OSF Saint Anthony's Health Center
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Aurora, Illinois, Stati Uniti, 60504
- Rush-Copley Medical Center
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Barrington, Illinois, Stati Uniti, 60010
- Advocate Good Shepherd Hospital
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Bloomington, Illinois, Stati Uniti, 61704
- Illinois CancerCare-Bloomington
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Canton, Illinois, Stati Uniti, 61520
- Illinois CancerCare-Canton
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Carbondale, Illinois, Stati Uniti, 62902
- Memorial Hospital of Carbondale
-
Carterville, Illinois, Stati Uniti, 62918
- SIH Cancer Institute
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Carthage, Illinois, Stati Uniti, 62321
- Illinois CancerCare-Carthage
-
Centralia, Illinois, Stati Uniti, 62801
- Centralia Oncology Clinic
-
Centralia, Illinois, Stati Uniti, 62801
- Saint Mary's Hospital
-
Chicago, Illinois, Stati Uniti, 60611
- Northwestern University
-
Chicago, Illinois, Stati Uniti, 60612
- University of Illinois
-
Chicago, Illinois, Stati Uniti, 60612
- John H Stroger Jr Hospital of Cook County
-
Chicago, Illinois, Stati Uniti, 60657
- Advocate Illinois Masonic Medical Center
-
Crystal Lake, Illinois, Stati Uniti, 60014
- AMG Crystal Lake - Oncology
-
Danville, Illinois, Stati Uniti, 61832
- Carle at The Riverfront
-
Decatur, Illinois, Stati Uniti, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, Stati Uniti, 62526
- Cancer Care Specialists of Illinois - Decatur
-
Dixon, Illinois, Stati Uniti, 61021
- Illinois CancerCare-Dixon
-
Downers Grove, Illinois, Stati Uniti, 60515
- Advocate Good Samaritan Hospital
-
Effingham, Illinois, Stati Uniti, 62401
- Crossroads Cancer Center
-
Effingham, Illinois, Stati Uniti, 62401
- Carle Physician Group-Effingham
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Elgin, Illinois, Stati Uniti, 60123
- Advocate Sherman Hospital
-
Eureka, Illinois, Stati Uniti, 61530
- Illinois CancerCare-Eureka
-
Galesburg, Illinois, Stati Uniti, 61401
- Western Illinois Cancer Treatment Center
-
Galesburg, Illinois, Stati Uniti, 61401
- Illinois CancerCare-Galesburg
-
Hazel Crest, Illinois, Stati Uniti, 60429
- Advocate South Suburban Hospital
-
Hinsdale, Illinois, Stati Uniti, 60521
- UChicago Medicine AdventHealth Cancer Institute Hinsdale
-
Kewanee, Illinois, Stati Uniti, 61443
- Illinois CancerCare-Kewanee Clinic
-
Lake Forest, Illinois, Stati Uniti, 60045
- Northwestern Medicine Lake Forest Hospital
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Libertyville, Illinois, Stati Uniti, 60048
- Condell Memorial Hospital
-
Libertyville, Illinois, Stati Uniti, 60048
- AMG Libertyville - Oncology
-
Macomb, Illinois, Stati Uniti, 61455
- Illinois CancerCare-Macomb
-
Mattoon, Illinois, Stati Uniti, 61938
- Carle Physician Group-Mattoon/Charleston
-
Mount Vernon, Illinois, Stati Uniti, 62864
- SSM Health Good Samaritan
-
O'Fallon, Illinois, Stati Uniti, 62269
- Cancer Care Center of O'Fallon
-
O'Fallon, Illinois, Stati Uniti, 62269
- HSHS Saint Elizabeth's Hospital
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Oak Lawn, Illinois, Stati Uniti, 60453-2699
- Advocate Christ Medical Center
-
Ottawa, Illinois, Stati Uniti, 61350
- Illinois CancerCare-Ottawa Clinic
-
Palos Heights, Illinois, Stati Uniti, 60463
- Advocate High Tech Medical Park
-
Park Ridge, Illinois, Stati Uniti, 60068
- Advocate Lutheran General Hospital
-
Pekin, Illinois, Stati Uniti, 61554
- Illinois CancerCare-Pekin
-
Pekin, Illinois, Stati Uniti, 61554
- OSF Saint Francis Radiation Oncology at Pekin
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Peoria, Illinois, Stati Uniti, 61636
- Methodist Medical Center of Illinois
-
Peoria, Illinois, Stati Uniti, 61637
- OSF Saint Francis Medical Center
-
Peoria, Illinois, Stati Uniti, 61615
- Illinois CancerCare-Peoria
-
Peoria, Illinois, Stati Uniti, 61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
-
Peru, Illinois, Stati Uniti, 61354
- Illinois CancerCare-Peru
-
Peru, Illinois, Stati Uniti, 61354
- Valley Radiation Oncology
-
Princeton, Illinois, Stati Uniti, 61356
- Illinois CancerCare-Princeton
-
Springfield, Illinois, Stati Uniti, 62702
- Southern Illinois University School of Medicine
-
Springfield, Illinois, Stati Uniti, 62702
- Springfield Clinic
-
Springfield, Illinois, Stati Uniti, 62781
- Springfield Memorial Hospital
-
Swansea, Illinois, Stati Uniti, 62226
- Southwest Illinois Health Services LLP
-
Urbana, Illinois, Stati Uniti, 61801
- Carle Cancer Center
-
Urbana, Illinois, Stati Uniti, 61801
- The Carle Foundation Hospital
-
Washington, Illinois, Stati Uniti, 61571
- Illinois CancerCare - Washington
-
Yorkville, Illinois, Stati Uniti, 60560
- Rush-Copley Healthcare Center
-
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Indiana
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Fort Wayne, Indiana, Stati Uniti, 46845
- Parkview Regional Medical Center
-
Indianapolis, Indiana, Stati Uniti, 46237
- Franciscan Health Indianapolis
-
Indianapolis, Indiana, Stati Uniti, 46219
- Community Cancer Center East
-
Indianapolis, Indiana, Stati Uniti, 46227
- Community Cancer Center South
-
Indianapolis, Indiana, Stati Uniti, 46256
- Community Cancer Center North
-
Kokomo, Indiana, Stati Uniti, 46904
- Community Howard Regional Health
-
Michigan City, Indiana, Stati Uniti, 46360
- Woodland Cancer Care Center
-
Mooresville, Indiana, Stati Uniti, 46158
- Franciscan Health Mooresville
-
Terre Haute, Indiana, Stati Uniti, 47804
- Union Hospital
-
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Iowa
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Ames, Iowa, Stati Uniti, 50010
- Mary Greeley Medical Center
-
Ames, Iowa, Stati Uniti, 50010
- McFarland Clinic - Ames
-
Ankeny, Iowa, Stati Uniti, 50023
- UI Health Care Mission Cancer and Blood - Ankeny Clinic
-
Boone, Iowa, Stati Uniti, 50036
- McFarland Clinic - Boone
-
Carroll, Iowa, Stati Uniti, 51401
- Saint Anthony Regional Hospital
-
Clive, Iowa, Stati Uniti, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, Stati Uniti, 50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
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Council Bluffs, Iowa, Stati Uniti, 51503
- Alegent Health Mercy Hospital
-
Creston, Iowa, Stati Uniti, 50801
- Greater Regional Medical Center
-
Des Moines, Iowa, Stati Uniti, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, Stati Uniti, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Stati Uniti, 50314
- Broadlawns Medical Center
-
Des Moines, Iowa, Stati Uniti, 50316
- Iowa Lutheran Hospital
-
Des Moines, Iowa, Stati Uniti, 50309
- UI Health Care Mission Cancer and Blood - Des Moines Clinic
-
Des Moines, Iowa, Stati Uniti, 50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
-
Fort Dodge, Iowa, Stati Uniti, 50501
- McFarland Clinic - Trinity Cancer Center
-
Fort Dodge, Iowa, Stati Uniti, 50501
- UI Healthcare Mission Cancer and Blood - Fort Dodge
-
Jefferson, Iowa, Stati Uniti, 50129
- McFarland Clinic - Jefferson
-
Marshalltown, Iowa, Stati Uniti, 50158
- McFarland Clinic - Marshalltown
-
West Des Moines, Iowa, Stati Uniti, 50266-7700
- Methodist West Hospital
-
West Des Moines, Iowa, Stati Uniti, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Garden City, Kansas, Stati Uniti, 67846
- Central Care Cancer Center - Garden City
-
Great Bend, Kansas, Stati Uniti, 67530
- Central Care Cancer Center - Great Bend
-
-
Kentucky
-
Bardstown, Kentucky, Stati Uniti, 40004
- CommonSpirit Saint Joseph Hospital - Bardstown
-
Corbin, Kentucky, Stati Uniti, 40701
- Commonwealth Cancer Center-Corbin
-
Lexington, Kentucky, Stati Uniti, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, Stati Uniti, 40509
- CommonSpirit Saint Joseph Medical Center - East Lexington
-
Lexington, Kentucky, Stati Uniti, 40504
- CommonSpirit Saint Joseph Hospital - Lexington
-
London, Kentucky, Stati Uniti, 40741
- CommonSpirit Saint Joseph Hospital London
-
Louisville, Kentucky, Stati Uniti, 40202
- The James Graham Brown Cancer Center at University of Louisville
-
Louisville, Kentucky, Stati Uniti, 40202
- Jewish Hospital
-
Louisville, Kentucky, Stati Uniti, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, Stati Uniti, 40215
- Saints Mary and Elizabeth Hospital
-
Shepherdsville, Kentucky, Stati Uniti, 40165
- Jewish Hospital Medical Center South
-
-
Louisiana
-
Baton Rouge, Louisiana, Stati Uniti, 70805
- LSU Health Baton Rouge-North Clinic
-
Baton Rouge, Louisiana, Stati Uniti, 70809
- Louisiana Hematology Oncology Associates LLC
-
Baton Rouge, Louisiana, Stati Uniti, 70809
- Mary Bird Perkins Cancer Center
-
Baton Rouge, Louisiana, Stati Uniti, 70808
- Our Lady of The Lake
-
Baton Rouge, Louisiana, Stati Uniti, 70808
- Our Lady of the Lake Physician Group
-
New Orleans, Louisiana, Stati Uniti, 70112
- University Medical Center New Orleans
-
New Orleans, Louisiana, Stati Uniti, 70112
- Louisiana State University Health Science Center
-
-
Maryland
-
Baltimore, Maryland, Stati Uniti, 21204
- Greater Baltimore Medical Center
-
Baltimore, Maryland, Stati Uniti, 21201
- University of Maryland/Greenebaum Cancer Center
-
Bel Air, Maryland, Stati Uniti, 21014
- UM Upper Chesapeake Medical Center
-
-
Massachusetts
-
Boston, Massachusetts, Stati Uniti, 02111
- Tufts Medical Center
-
Lowell, Massachusetts, Stati Uniti, 01854
- Lowell General Hospital
-
Springfield, Massachusetts, Stati Uniti, 01104
- Mercy Medical Center
-
Worcester, Massachusetts, Stati Uniti, 01655
- UMass Memorial Medical Center - University Campus
-
-
Michigan
-
Ann Arbor, Michigan, Stati Uniti, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Battle Creek, Michigan, Stati Uniti, 49017
- Bronson Battle Creek
-
Bay City, Michigan, Stati Uniti, 48706
- McLaren Cancer Institute-Bay City
-
Brighton, Michigan, Stati Uniti, 48114
- Trinity Health IHA Medical Group Hematology Oncology - Brighton
-
Brighton, Michigan, Stati Uniti, 48114
- Trinity Health Medical Center - Brighton
-
Canton, Michigan, Stati Uniti, 48188
- Trinity Health IHA Medical Group Hematology Oncology - Canton
-
Canton, Michigan, Stati Uniti, 48188
- Trinity Health Medical Center - Canton
-
Caro, Michigan, Stati Uniti, 48723
- Caro Cancer Center
-
Chelsea, Michigan, Stati Uniti, 48118
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
-
Chelsea, Michigan, Stati Uniti, 48118
- Chelsea Hospital
-
Clarkston, Michigan, Stati Uniti, 48346
- McLaren Cancer Institute-Clarkston
-
Clarkston, Michigan, Stati Uniti, 48346
- Hematology Oncology Consultants-Clarkston
-
Clarkston, Michigan, Stati Uniti, 48346
- Newland Medical Associates-Clarkston
-
Detroit, Michigan, Stati Uniti, 48201
- Wayne State University/Karmanos Cancer Institute
-
Detroit, Michigan, Stati Uniti, 48236
- Henry Ford Health Saint John Hospital
-
East China Township, Michigan, Stati Uniti, 48054
- Henry Ford River District Hospital
-
Farmington Hills, Michigan, Stati Uniti, 48334
- Weisberg Cancer Treatment Center
-
Flint, Michigan, Stati Uniti, 48532
- McLaren Cancer Institute-Flint
-
Flint, Michigan, Stati Uniti, 48532
- Singh and Arora Hematology Oncology PC
-
Flint, Michigan, Stati Uniti, 48503
- Hurley Medical Center
-
Flint, Michigan, Stati Uniti, 48503
- Genesee Hematology Oncology PC
-
Flint, Michigan, Stati Uniti, 48503
- Genesys Hurley Cancer Institute
-
Flint, Michigan, Stati Uniti, 48503
- Cancer Hematology Centers - Flint
-
Grand Rapids, Michigan, Stati Uniti, 49503
- Trinity Health Grand Rapids Hospital
-
Grand Rapids, Michigan, Stati Uniti, 49503
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital
-
Grand Rapids, Michigan, Stati Uniti, 49503
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
-
Grosse Pointe Woods, Michigan, Stati Uniti, 48236
- Henry Ford Saint John Hospital - Academic
-
Grosse Pointe Woods, Michigan, Stati Uniti, 48236
- Henry Ford Saint John Hospital - Breast
-
Grosse Pointe Woods, Michigan, Stati Uniti, 48236
- Henry Ford Saint John Hospital - Van Elslander
-
Kalamazoo, Michigan, Stati Uniti, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, Stati Uniti, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, Stati Uniti, 49009
- Beacon Kalamazoo Cancer Center
-
Kalamazoo, Michigan, Stati Uniti, 49048
- Beacon Kalamazoo
-
Lansing, Michigan, Stati Uniti, 48912
- Mid-Michigan Physicians-Lansing
-
Lansing, Michigan, Stati Uniti, 48910
- Karmanos Cancer Institute at McLaren Greater Lansing
-
Lansing, Michigan, Stati Uniti, 48912
- University of Michigan Health - Sparrow Lansing
-
Lapeer, Michigan, Stati Uniti, 48446
- McLaren Cancer Institute-Lapeer Region
-
Livonia, Michigan, Stati Uniti, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Livonia, Michigan, Stati Uniti, 48154
- Hope Cancer Clinic
-
Macomb, Michigan, Stati Uniti, 48044
- Henry Ford Warren Hospital - Breast Macomb
-
Macomb, Michigan, Stati Uniti, 48044
- Henry Ford Saint John Hospital - Macomb Medical
-
Marlette, Michigan, Stati Uniti, 48453
- Saint Mary's Oncology/Hematology Associates of Marlette
-
Mount Clemens, Michigan, Stati Uniti, 48043
- McLaren Cancer Institute-Macomb
-
Mount Pleasant, Michigan, Stati Uniti, 48858
- McLaren Cancer Institute-Central Michigan
-
Muskegon, Michigan, Stati Uniti, 49444
- Trinity Health Muskegon Hospital
-
Niles, Michigan, Stati Uniti, 49120
- Corewell Health Lakeland Hospitals - Niles Hospital
-
Norton Shores, Michigan, Stati Uniti, 49444
- Cancer and Hematology Centers of Western Michigan - Norton Shores
-
Petoskey, Michigan, Stati Uniti, 49770
- McLaren Cancer Institute-Northern Michigan
-
Pontiac, Michigan, Stati Uniti, 48341
- Hope Cancer Center
-
Pontiac, Michigan, Stati Uniti, 48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Pontiac, Michigan, Stati Uniti, 48341
- Michigan Healthcare Professionals Pontiac
-
Pontiac, Michigan, Stati Uniti, 48341
- Trinity Health IHA Medical Group-Alice Gustafson Center
-
Port Huron, Michigan, Stati Uniti, 48060
- McLaren-Port Huron
-
Reed City, Michigan, Stati Uniti, 49677
- Corewell Health Reed City Hospital
-
Rochester Hills, Michigan, Stati Uniti, 48309
- Henry Ford Rochester Hospital
-
Saginaw, Michigan, Stati Uniti, 48604
- Oncology Hematology Associates of Saginaw Valley PC
-
Saginaw, Michigan, Stati Uniti, 48601
- MyMichigan Medical Center Saginaw
-
Saint Joseph, Michigan, Stati Uniti, 49085
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
-
Saint Joseph, Michigan, Stati Uniti, 49085
- Corewell Health Lakeland Hospitals - Saint Joseph Hospital
-
Sterling Heights, Michigan, Stati Uniti, 48312
- Bhadresh Nayak MD PC-Sterling Heights
-
Tawas City, Michigan, Stati Uniti, 48764
- MyMichigan Medical Center Tawas
-
Traverse City, Michigan, Stati Uniti, 49684
- Munson Medical Center
-
Warren, Michigan, Stati Uniti, 48088
- Advanced Breast Care Center PLLC
-
Warren, Michigan, Stati Uniti, 48093
- Macomb Hematology Oncology PC
-
Warren, Michigan, Stati Uniti, 48093
- Henry Ford Madison Heights Hospital - Breast
-
Warren, Michigan, Stati Uniti, 48093
- Henry Ford Health Warren Hospital
-
Warren, Michigan, Stati Uniti, 48093
- Henry Ford Warren Hospital - GLCMS
-
West Branch, Michigan, Stati Uniti, 48661
- Saint Mary's Oncology/Hematology Associates of West Branch
-
Wyoming, Michigan, Stati Uniti, 49519
- University of Michigan Health - West
-
Ypsilanti, Michigan, Stati Uniti, 48197
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
-
Ypsilanti, Michigan, Stati Uniti, 48106
- Huron Gastroenterology PC
-
-
Minnesota
-
Bemidji, Minnesota, Stati Uniti, 56601
- Sanford Joe Lueken Cancer Center
-
Burnsville, Minnesota, Stati Uniti, 55337
- Fairview Ridges Hospital
-
Burnsville, Minnesota, Stati Uniti, 55337
- Minnesota Oncology - Burnsville
-
Cambridge, Minnesota, Stati Uniti, 55008
- Cambridge Medical Center
-
Coon Rapids, Minnesota, Stati Uniti, 55433
- Mercy Hospital
-
Edina, Minnesota, Stati Uniti, 55435
- Fairview Southdale Hospital
-
Fridley, Minnesota, Stati Uniti, 55432
- Unity Hospital
-
Maple Grove, Minnesota, Stati Uniti, 55369
- Fairview Clinics and Surgery Center Maple Grove
-
Maplewood, Minnesota, Stati Uniti, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Stati Uniti, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Stati Uniti, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Stati Uniti, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Stati Uniti, 55454
- Health Partners Inc
-
Minneapolis, Minnesota, Stati Uniti, 55417
- Minneapolis VA Medical Center
-
Monticello, Minnesota, Stati Uniti, 55362
- Monticello Cancer Center
-
New Ulm, Minnesota, Stati Uniti, 56073
- New Ulm Medical Center
-
Princeton, Minnesota, Stati Uniti, 55371
- Fairview Northland Medical Center
-
Robbinsdale, Minnesota, Stati Uniti, 55422
- North Memorial Medical Health Center
-
Saint Louis Park, Minnesota, Stati Uniti, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, Stati Uniti, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Stati Uniti, 55102
- United Hospital
-
Shakopee, Minnesota, Stati Uniti, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Stati Uniti, 55082
- Lakeview Hospital
-
Thief River Falls, Minnesota, Stati Uniti, 56701
- Sanford Thief River Falls Medical Center
-
Waconia, Minnesota, Stati Uniti, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Stati Uniti, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Stati Uniti, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
Worthington, Minnesota, Stati Uniti, 56187
- Sanford Cancer Center Worthington
-
Wyoming, Minnesota, Stati Uniti, 55092
- Fairview Lakes Medical Center
-
-
Missouri
-
Ballwin, Missouri, Stati Uniti, 63011
- Mercy Oncology and Hematology - Clayton-Clarkson
-
Bolivar, Missouri, Stati Uniti, 65613
- Central Care Cancer Center - Bolivar
-
Bonne Terre, Missouri, Stati Uniti, 63628
- Parkland Health Center-Bonne Terre
-
Branson, Missouri, Stati Uniti, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, Stati Uniti, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Stati Uniti, 63703
- Mercy Cancer Center - Cape Girardeau
-
Jefferson City, Missouri, Stati Uniti, 65109
- MU Health Care Goldschmidt Cancer Center
-
Joplin, Missouri, Stati Uniti, 64804
- Freeman Health System
-
Joplin, Missouri, Stati Uniti, 64804
- Mercy Hospital Joplin
-
Rolla, Missouri, Stati Uniti, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Rolla, Missouri, Stati Uniti, 65401
- Phelps Health Delbert Day Cancer Institute
-
Saint Joseph, Missouri, Stati Uniti, 64506
- Heartland Regional Medical Center
-
Sainte Genevieve, Missouri, Stati Uniti, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, Stati Uniti, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Stati Uniti, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, Stati Uniti, 63131
- Missouri Baptist Medical Center
-
St Louis, Missouri, Stati Uniti, 63109
- Mercy Infusion Center - Chippewa
-
St Louis, Missouri, Stati Uniti, 63141
- Mercy Hospital Saint Louis
-
St Louis, Missouri, Stati Uniti, 63128
- Mercy Hospital South
-
Sullivan, Missouri, Stati Uniti, 63080
- Missouri Baptist Sullivan Hospital
-
Washington, Missouri, Stati Uniti, 63090
- Mercy Hospital Washington
-
-
Montana
-
Anaconda, Montana, Stati Uniti, 59711
- Community Hospital of Anaconda
-
Billings, Montana, Stati Uniti, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, Stati Uniti, 59101
- Saint Vincent Healthcare
-
Billings, Montana, Stati Uniti, 59102
- Saint Vincent Frontier Cancer Center
-
Bozeman, Montana, Stati Uniti, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, Stati Uniti, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Stati Uniti, 59405
- Great Falls Clinic
-
Great Falls, Montana, Stati Uniti, 59405
- Benefis Sletten Cancer Institute
-
Helena, Montana, Stati Uniti, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, Stati Uniti, 59901
- Logan Health Medical Center
-
Missoula, Montana, Stati Uniti, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, Stati Uniti, 59804
- Community Medical Center
-
-
Nebraska
-
Bellevue, Nebraska, Stati Uniti, 68123
- Nebraska Medicine-Bellevue
-
Grand Island, Nebraska, Stati Uniti, 68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Kearney, Nebraska, Stati Uniti, 68847
- CHI Health Good Samaritan
-
Lincoln, Nebraska, Stati Uniti, 68510
- Saint Elizabeth Regional Medical Center
-
Omaha, Nebraska, Stati Uniti, 68198
- University of Nebraska Medical Center
-
Omaha, Nebraska, Stati Uniti, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Stati Uniti, 68118
- Nebraska Medicine-Village Pointe
-
Omaha, Nebraska, Stati Uniti, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, Stati Uniti, 68130
- Alegent Health Lakeside Hospital
-
Papillion, Nebraska, Stati Uniti, 68046
- Midlands Community Hospital
-
-
Nevada
-
Carson City, Nevada, Stati Uniti, 89703
- Carson Tahoe Regional Medical Center
-
Henderson, Nevada, Stati Uniti, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Stati Uniti, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, Stati Uniti, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, Stati Uniti, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, Stati Uniti, 89052
- Comprehensive Cancer Centers of Nevada-Horizon Ridge
-
Henderson, Nevada, Stati Uniti, 89074
- Las Vegas Urology - Green Valley
-
Henderson, Nevada, Stati Uniti, 89074
- Las Vegas Urology - Pebble
-
Henderson, Nevada, Stati Uniti, 89074
- Urology Specialists of Nevada - Green Valley
-
Henderson, Nevada, Stati Uniti, 89074
- Oncology Las Vegas - Henderson
-
Las Vegas, Nevada, Stati Uniti, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, Stati Uniti, 89109
- Sunrise Hospital and Medical Center
-
Las Vegas, Nevada, Stati Uniti, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, Stati Uniti, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Stati Uniti, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Stati Uniti, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Stati Uniti, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, Stati Uniti, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, Stati Uniti, 89144
- Comprehensive Cancer Centers of Nevada - Town Center
-
Las Vegas, Nevada, Stati Uniti, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Stati Uniti, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Stati Uniti, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Stati Uniti, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, Stati Uniti, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, Stati Uniti, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, Stati Uniti, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, Stati Uniti, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, Stati Uniti, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, Stati Uniti, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, Stati Uniti, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, Stati Uniti, 89128
- Ann M Wierman MD LTD
-
Las Vegas, Nevada, Stati Uniti, 89074
- Las Vegas Urology - Pecos
-
Las Vegas, Nevada, Stati Uniti, 89102
- Desert West Surgery
-
Las Vegas, Nevada, Stati Uniti, 89103
- Hope Cancer Care of Nevada
-
Las Vegas, Nevada, Stati Uniti, 89106
- Urology Specialists of Nevada - Central
-
Las Vegas, Nevada, Stati Uniti, 89113
- Las Vegas Prostate Cancer Center
-
Las Vegas, Nevada, Stati Uniti, 89113
- Las Vegas Urology - Sunset
-
Las Vegas, Nevada, Stati Uniti, 89128
- Las Vegas Urology - Cathedral Rock
-
Las Vegas, Nevada, Stati Uniti, 89128
- Las Vegas Urology - Smoke Ranch
-
Las Vegas, Nevada, Stati Uniti, 89128
- Urology Specialists of Nevada - Northwest
-
Las Vegas, Nevada, Stati Uniti, 89169
- University Cancer Center
-
Las Vegas, Nevada, Stati Uniti, 89113
- Urology Specialists of Nevada - Southwest
-
Las Vegas, Nevada, Stati Uniti, 89128
- Oncology Las Vegas - Tenaya
-
Las Vegas, Nevada, Stati Uniti, 89183
- OptumCare Cancer Care at Fort Apache
-
Pahrump, Nevada, Stati Uniti, 89048
- Hope Cancer Care of Nevada-Pahrump
-
Reno, Nevada, Stati Uniti, 89502
- Renown Regional Medical Center
-
Reno, Nevada, Stati Uniti, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, Stati Uniti, 89509
- Radiation Oncology Associates
-
-
New Hampshire
-
Lebanon, New Hampshire, Stati Uniti, 03756
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
-
New Jersey
-
Cape May Court House, New Jersey, Stati Uniti, 08210
- AtlantiCare Health Park-Cape May Court House
-
Egg Harbor, New Jersey, Stati Uniti, 08234
- AtlantiCare Surgery Center
-
Hamilton, New Jersey, Stati Uniti, 08690
- The Cancer Institute of New Jersey Hamilton
-
Jersey City, New Jersey, Stati Uniti, 07302
- Jersey City Medical Center
-
Livingston, New Jersey, Stati Uniti, 07039
- Cooperman Barnabas Medical Center
-
Moorestown, New Jersey, Stati Uniti, 08057
- Virtua Samson Cancer Center
-
Morristown, New Jersey, Stati Uniti, 07960
- Morristown Medical Center
-
Mount Holly, New Jersey, Stati Uniti, 08060
- Virtua Memorial
-
New Brunswick, New Jersey, Stati Uniti, 08903
- Rutgers Cancer Institute of New Jersey
-
Newark, New Jersey, Stati Uniti, 07101
- Rutgers New Jersey Medical School
-
Summit, New Jersey, Stati Uniti, 07902
- Overlook Hospital
-
Voorhees Township, New Jersey, Stati Uniti, 08043
- Virtua Voorhees
-
-
New Mexico
-
Albuquerque, New Mexico, Stati Uniti, 87106
- University of New Mexico Cancer Center
-
-
New York
-
Brooklyn, New York, Stati Uniti, 11215
- New York-Presbyterian/Brooklyn Methodist Hospital
-
Buffalo, New York, Stati Uniti, 14263
- Roswell Park Cancer Institute
-
New York, New York, Stati Uniti, 10065
- NYP/Weill Cornell Medical Center
-
Rochester, New York, Stati Uniti, 14642
- University of Rochester
-
Stony Brook, New York, Stati Uniti, 11794
- Stony Brook University Medical Center
-
Syracuse, New York, Stati Uniti, 13210
- State University of New York Upstate Medical University
-
Syracuse, New York, Stati Uniti, 13215
- SUNY Upstate Medical Center-Community Campus
-
The Bronx, New York, Stati Uniti, 10461
- Montefiore Medical Center-Einstein Campus
-
The Bronx, New York, Stati Uniti, 10467
- Montefiore Medical Center - Moses Campus
-
The Bronx, New York, Stati Uniti, 10461
- Montefiore Medical Center-Weiler Hospital
-
-
North Carolina
-
Asheville, North Carolina, Stati Uniti, 28803
- AdventHealth Infusion Center Asheville
-
Charlotte, North Carolina, Stati Uniti, 28204
- Novant Health Presbyterian Medical Center
-
Clyde, North Carolina, Stati Uniti, 28721
- AdventHealth Infusion Center Haywood
-
Gastonia, North Carolina, Stati Uniti, 28054
- CaroMont Regional Medical Center
-
Greenville, North Carolina, Stati Uniti, 27834
- East Carolina University
-
Hendersonville, North Carolina, Stati Uniti, 28792
- AdventHealth Hendersonville
-
Huntersville, North Carolina, Stati Uniti, 28078
- Novant Health Cancer Institute - Huntersville
-
Huntersville, North Carolina, Stati Uniti, 28078
- Novant Health Presbyterian Medical Center Huntersville
-
Kernersville, North Carolina, Stati Uniti, 27284
- Novant Health Cancer Institute - Kernersville
-
Matthews, North Carolina, Stati Uniti, 28105
- Novant Health Cancer Institute - Matthews
-
Mooresville, North Carolina, Stati Uniti, 28117
- Novant Health Cancer Institute - Mooresville
-
Mount Airy, North Carolina, Stati Uniti, 27030
- Novant Health Cancer Institute - Mount Airy
-
New Bern, North Carolina, Stati Uniti, 28561
- CarolinaEast Medical Center
-
North Wilkesboro, North Carolina, Stati Uniti, 28659
- Novant Health Cancer Institute - Wilkesboro
-
Statesville, North Carolina, Stati Uniti, 28625
- Novant Health Cancer Institute - Statesville
-
Thomasville, North Carolina, Stati Uniti, 27360
- Novant Health Cancer Institute - Thomasville
-
Weaverville, North Carolina, Stati Uniti, 28787
- AdventHealth Infusion Center Weaverville
-
Winston-Salem, North Carolina, Stati Uniti, 27103
- Novant Health Forsyth Medical Center
-
-
North Dakota
-
Bismarck, North Dakota, Stati Uniti, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, Stati Uniti, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, Stati Uniti, 58122
- Sanford Broadway Medical Center
-
Fargo, North Dakota, Stati Uniti, 58103
- Sanford South University Medical Center
-
Fargo, North Dakota, Stati Uniti, 58103
- Southpointe-Sanford Medical Center Fargo
-
Fargo, North Dakota, Stati Uniti, 58104
- Sanford Medical Center Fargo
-
-
Ohio
-
Akron, Ohio, Stati Uniti, 44304
- Summa Health System - Akron Campus
-
Avon, Ohio, Stati Uniti, 44011
- UH Seidman Cancer Center at UH Avon Health Center
-
Barberton, Ohio, Stati Uniti, 44203
- Summa Health System - Barberton Campus
-
Beachwood, Ohio, Stati Uniti, 44122
- UHHS-Chagrin Highlands Medical Center
-
Canton, Ohio, Stati Uniti, 44708
- Cleveland Clinic Mercy Hospital
-
Centerville, Ohio, Stati Uniti, 45459
- Miami Valley Hospital South
-
Chardon, Ohio, Stati Uniti, 44024
- Geauga Hospital
-
Cincinnati, Ohio, Stati Uniti, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, Stati Uniti, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, Stati Uniti, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, Stati Uniti, 45255
- TriHealth Cancer Institute-Anderson
-
Cleveland, Ohio, Stati Uniti, 44106
- Case Western Reserve University
-
Cleveland, Ohio, Stati Uniti, 44109
- MetroHealth Medical Center
-
Cleveland, Ohio, Stati Uniti, 44195
- Cleveland Clinic Foundation
-
Cleveland, Ohio, Stati Uniti, 44111
- Cleveland Clinic Cancer Center/Fairview Hospital
-
Columbus, Ohio, Stati Uniti, 43210
- Ohio State University Comprehensive Cancer Center
-
Dayton, Ohio, Stati Uniti, 45409
- Miami Valley Hospital
-
Dayton, Ohio, Stati Uniti, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, Stati Uniti, 45409
- Premier Blood and Cancer Center
-
Elyria, Ohio, Stati Uniti, 44035
- Mercy Cancer Center-Elyria
-
Franklin, Ohio, Stati Uniti, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Greenville, Ohio, Stati Uniti, 45331
- Miami Valley Cancer Care and Infusion
-
Mansfield, Ohio, Stati Uniti, 44906
- Cleveland Clinic Cancer Center Mansfield
-
Mayfield Heights, Ohio, Stati Uniti, 44124
- Hillcrest Hospital Cancer Center
-
Medina, Ohio, Stati Uniti, 44256
- Summa Health Medina Medical Center
-
Mentor, Ohio, Stati Uniti, 44060
- UH Seidman Cancer Center at Lake Health Mentor Campus
-
Middleburg Heights, Ohio, Stati Uniti, 44130
- UH Seidman Cancer Center at Southwest General Hospital
-
Parma, Ohio, Stati Uniti, 44129
- University Hospitals Parma Medical Center
-
Ravenna, Ohio, Stati Uniti, 44266
- University Hospitals Portage Medical Center
-
Sandusky, Ohio, Stati Uniti, 44870
- North Coast Cancer Care
-
Strongsville, Ohio, Stati Uniti, 44136
- Cleveland Clinic Cancer Center Strongsville
-
Troy, Ohio, Stati Uniti, 45373
- Upper Valley Medical Center
-
Westlake, Ohio, Stati Uniti, 44145
- UH Seidman Cancer Center at Saint John Medical Center
-
Westlake, Ohio, Stati Uniti, 44145
- UHHS-Westlake Medical Center
-
-
Oklahoma
-
Lawton, Oklahoma, Stati Uniti, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, Stati Uniti, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, Stati Uniti, 73120
- Mercy Hospital Oklahoma City
-
Tulsa, Oklahoma, Stati Uniti, 74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
-
Oregon
-
Baker City, Oregon, Stati Uniti, 97814
- Saint Alphonsus Cancer Care Center-Baker City
-
Bend, Oregon, Stati Uniti, 97701
- Saint Charles Health System
-
Clackamas, Oregon, Stati Uniti, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, Stati Uniti, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, Stati Uniti, 97420
- Bay Area Hospital
-
Newberg, Oregon, Stati Uniti, 97132
- Providence Newberg Medical Center
-
Ontario, Oregon, Stati Uniti, 97914
- Saint Alphonsus Cancer Care Center-Ontario
-
Oregon City, Oregon, Stati Uniti, 97045
- Providence Willamette Falls Medical Center
-
Portland, Oregon, Stati Uniti, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Stati Uniti, 97225
- Providence Saint Vincent Medical Center
-
Redmond, Oregon, Stati Uniti, 97756
- Saint Charles Health System-Redmond
-
-
Pennsylvania
-
Allentown, Pennsylvania, Stati Uniti, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, Stati Uniti, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Chadds Ford, Pennsylvania, Stati Uniti, 19317
- Christiana Care Health System-Concord Health Center
-
Danville, Pennsylvania, Stati Uniti, 17822
- Geisinger Medical Center
-
East Stroudsburg, Pennsylvania, Stati Uniti, 18301
- Pocono Medical Center
-
Erie, Pennsylvania, Stati Uniti, 16505
- UPMC Hillman Cancer Center Erie
-
Farrell, Pennsylvania, Stati Uniti, 16121
- UPMC Cancer Center at UPMC Horizon
-
Hazleton, Pennsylvania, Stati Uniti, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hazleton, Pennsylvania, Stati Uniti, 18201
- Lehigh Valley Hospital-Hazleton
-
Hershey, Pennsylvania, Stati Uniti, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Lewisburg, Pennsylvania, Stati Uniti, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, Stati Uniti, 17044
- Lewistown Hospital
-
Monroeville, Pennsylvania, Stati Uniti, 15146
- UPMC Hillman Cancer Center - Monroeville
-
Monroeville, Pennsylvania, Stati Uniti, 15146
- UPMC Cancer Center - Monroeville
-
Philadelphia, Pennsylvania, Stati Uniti, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, Stati Uniti, 19114
- Jefferson Torresdale Hospital
-
Pittsburgh, Pennsylvania, Stati Uniti, 15232
- UPMC Hillman Cancer Center
-
Pittsburgh, Pennsylvania, Stati Uniti, 15232
- UPMC-Shadyside Hospital
-
Pittsburgh, Pennsylvania, Stati Uniti, 15237
- UPMC-Passavant Hospital
-
Pittsburgh, Pennsylvania, Stati Uniti, 15243
- UPMC-Saint Clair Hospital Cancer Center
-
Pottsville, Pennsylvania, Stati Uniti, 17901
- Geisinger Cancer Services-Pottsville
-
Scranton, Pennsylvania, Stati Uniti, 18510
- Community Medical Center
-
West Reading, Pennsylvania, Stati Uniti, 19611
- Reading Hospital
-
Wilkes-Barre, Pennsylvania, Stati Uniti, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Willow Grove, Pennsylvania, Stati Uniti, 19090
- Asplundh Cancer Pavilion
-
-
South Carolina
-
Boiling Springs, South Carolina, Stati Uniti, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Charleston, South Carolina, Stati Uniti, 29425
- Medical University of South Carolina
-
Easley, South Carolina, Stati Uniti, 29640
- Prisma Health Cancer Institute - Easley
-
Gaffney, South Carolina, Stati Uniti, 29341
- Gibbs Cancer Center-Gaffney
-
Greenville, South Carolina, Stati Uniti, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, Stati Uniti, 29607
- Saint Francis Cancer Center
-
Greenville, South Carolina, Stati Uniti, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, Stati Uniti, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, Stati Uniti, 29601
- Saint Francis Hospital
-
Greer, South Carolina, Stati Uniti, 29650
- Prisma Health Cancer Institute - Greer
-
Greer, South Carolina, Stati Uniti, 29651
- Gibbs Cancer Center-Pelham
-
Seneca, South Carolina, Stati Uniti, 29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg, South Carolina, Stati Uniti, 29303
- Spartanburg Medical Center
-
Union, South Carolina, Stati Uniti, 29379
- SMC Center for Hematology Oncology Union
-
-
South Dakota
-
Aberdeen, South Dakota, Stati Uniti, 57401
- Avera Cancer Institute-Aberdeen
-
Sioux Falls, South Dakota, Stati Uniti, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, Stati Uniti, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Stati Uniti, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Nashville, Tennessee, Stati Uniti, 37232
- Vanderbilt University/Ingram Cancer Center
-
-
Texas
-
Amarillo, Texas, Stati Uniti, 79106
- The Don and Sybil Harrington Cancer Center
-
Austin, Texas, Stati Uniti, 78712
- University of Texas at Austin
-
Austin, Texas, Stati Uniti, 78701
- Dell Seton Medical Center at The University of Texas
-
Bryan, Texas, Stati Uniti, 77802
- Saint Joseph Regional Cancer Center
-
Dallas, Texas, Stati Uniti, 75235
- Parkland Memorial Hospital
-
Dallas, Texas, Stati Uniti, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
Houston, Texas, Stati Uniti, 77030
- Memorial Hermann Texas Medical Center
-
Humble, Texas, Stati Uniti, 77338
- Memorial Hermann Northeast Hospital
-
-
Utah
-
American Fork, Utah, Stati Uniti, 84003
- American Fork Hospital / Huntsman Intermountain Cancer Center
-
Cedar City, Utah, Stati Uniti, 84720
- Sandra L Maxwell Cancer Center
-
Logan, Utah, Stati Uniti, 84321
- Logan Regional Hospital
-
Murray, Utah, Stati Uniti, 84107
- Intermountain Medical Center
-
Ogden, Utah, Stati Uniti, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, Stati Uniti, 84604
- Utah Valley Regional Medical Center
-
Riverton, Utah, Stati Uniti, 84065
- Riverton Hospital
-
Salt Lake City, Utah, Stati Uniti, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, Stati Uniti, 84143
- LDS Hospital
-
St. George, Utah, Stati Uniti, 84770
- Saint George Regional Medical Center
-
-
Vermont
-
Saint Johnsbury, Vermont, Stati Uniti, 05819
- Dartmouth Cancer Center - North
-
-
Virginia
-
Richmond, Virginia, Stati Uniti, 23235
- VCU Massey Cancer Center at Stony Point
-
Richmond, Virginia, Stati Uniti, 23298
- VCU Massey Comprehensive Cancer Center
-
-
Washington
-
Aberdeen, Washington, Stati Uniti, 98520
- Providence Regional Cancer System-Aberdeen
-
Auburn, Washington, Stati Uniti, 98001
- MultiCare Auburn Medical Center
-
Bellevue, Washington, Stati Uniti, 98004
- Overlake Medical Center
-
Bellingham, Washington, Stati Uniti, 98225
- PeaceHealth Saint Joseph Medical Center
-
Burien, Washington, Stati Uniti, 98166
- Saint Anne Hospital
-
Centralia, Washington, Stati Uniti, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, Stati Uniti, 98026
- Swedish Cancer Institute-Edmonds
-
Enumclaw, Washington, Stati Uniti, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, Stati Uniti, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, Stati Uniti, 98003
- Saint Francis Hospital
-
Gig Harbor, Washington, Stati Uniti, 98335
- MultiCare Gig Harbor Medical Park
-
Issaquah, Washington, Stati Uniti, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, Stati Uniti, 99336
- Kadlec Clinic Hematology and Oncology
-
Lacey, Washington, Stati Uniti, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, Stati Uniti, 98499
- Saint Clare Hospital
-
Longview, Washington, Stati Uniti, 98632
- PeaceHealth Saint John Medical Center
-
Mount Vernon, Washington, Stati Uniti, 98274
- Skagit Regional Health Cancer Care Center
-
Port Townsend, Washington, Stati Uniti, 98368
- Jefferson Healthcare
-
Poulsbo, Washington, Stati Uniti, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Puyallup, Washington, Stati Uniti, 98372
- MultiCare Good Samaritan Hospital
-
Renton, Washington, Stati Uniti, 98055
- Valley Medical Center
-
Seattle, Washington, Stati Uniti, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, Stati Uniti, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, Stati Uniti, 98104
- Pacific Gynecology Specialists
-
Seattle, Washington, Stati Uniti, 98122-5711
- Swedish Medical Center-Cherry Hill
-
Sedro-Woolley, Washington, Stati Uniti, 98284
- PeaceHealth United General Medical Center
-
Shelton, Washington, Stati Uniti, 98584
- Providence Regional Cancer System-Shelton
-
Silverdale, Washington, Stati Uniti, 98383
- Saint Joseph Medical Center Hematology and Oncology - Silverdale
-
Spokane, Washington, Stati Uniti, 99204
- MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
-
Spokane, Washington, Stati Uniti, 99218
- MultiCare Deaconess Cancer and Blood Specialty Center - North
-
Spokane Valley, Washington, Stati Uniti, 99216
- MultiCare Deaconess Cancer and Blood Specialty Center - Valley
-
Tacoma, Washington, Stati Uniti, 98405
- Mary Bridge Children's Hospital and Health Center
-
Tacoma, Washington, Stati Uniti, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, Stati Uniti, 98405
- MultiCare Tacoma General Hospital
-
Tacoma, Washington, Stati Uniti, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Vancouver, Washington, Stati Uniti, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, Stati Uniti, 99362
- Providence Saint Mary Regional Cancer Center
-
Yakima, Washington, Stati Uniti, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
Yelm, Washington, Stati Uniti, 98597
- Providence Regional Cancer System-Yelm
-
-
Wisconsin
-
Appleton, Wisconsin, Stati Uniti, 54911
- ThedaCare Regional Cancer Center
-
Burlington, Wisconsin, Stati Uniti, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Eau Claire, Wisconsin, Stati Uniti, 54701
- Marshfield Medical Center-EC Cancer Center
-
Eau Claire, Wisconsin, Stati Uniti, 54701
- HSHS Sacred Heart Hospital
-
Germantown, Wisconsin, Stati Uniti, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, Stati Uniti, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, Stati Uniti, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, Stati Uniti, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, Stati Uniti, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Kenosha, Wisconsin, Stati Uniti, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, Stati Uniti, 54601
- Gundersen Lutheran Medical Center
-
Manitowoc, Wisconsin, Stati Uniti, 54221
- Holy Family Memorial Hospital
-
Marinette, Wisconsin, Stati Uniti, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marshfield, Wisconsin, Stati Uniti, 54449
- Marshfield Medical Center-Marshfield
-
Menomonee Falls, Wisconsin, Stati Uniti, 53051
- Froedtert Menomonee Falls Hospital
-
Milwaukee, Wisconsin, Stati Uniti, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, Stati Uniti, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, Stati Uniti, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, Stati Uniti, 53233
- Aurora Sinai Medical Center
-
Minocqua, Wisconsin, Stati Uniti, 54548
- Marshfield Medical Center - Minocqua
-
Mukwonago, Wisconsin, Stati Uniti, 53149
- ProHealth D N Greenwald Center
-
New Richmond, Wisconsin, Stati Uniti, 54017
- Cancer Center of Western Wisconsin
-
Oak Creek, Wisconsin, Stati Uniti, 53154
- Drexel Town Square Health Center
-
Oconomowoc, Wisconsin, Stati Uniti, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oconto Falls, Wisconsin, Stati Uniti, 54154
- Saint Vincent Hospital Cancer Center at Oconto Falls
-
Oshkosh, Wisconsin, Stati Uniti, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, Stati Uniti, 53406
- Aurora Cancer Care-Racine
-
Rice Lake, Wisconsin, Stati Uniti, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, Stati Uniti, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Sheboygan, Wisconsin, Stati Uniti, 53081
- HSHS Saint Nicholas Hospital
-
Stevens Point, Wisconsin, Stati Uniti, 54482
- Marshfield Medical Center-River Region at Stevens Point
-
Sturgeon Bay, Wisconsin, Stati Uniti, 54235-1495
- Saint Vincent Hospital Cancer Center at Sturgeon Bay
-
Summit, Wisconsin, Stati Uniti, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, Stati Uniti, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, Stati Uniti, 53188
- UW Cancer Center at ProHealth Care
-
Waukesha, Wisconsin, Stati Uniti, 53188
- ProHealth Waukesha Memorial Hospital
-
Wauwatosa, Wisconsin, Stati Uniti, 53226
- Aurora Cancer Care-Milwaukee West
-
West Allis, Wisconsin, Stati Uniti, 53227
- Aurora West Allis Medical Center
-
West Bend, Wisconsin, Stati Uniti, 53095
- Froedtert West Bend Hospital/Kraemer Cancer Center
-
Weston, Wisconsin, Stati Uniti, 54476
- Marshfield Medical Center - Weston
-
-
Wyoming
-
Cheyenne, Wyoming, Stati Uniti, 82001
- Cheyenne Regional Medical Center-West
-
Cody, Wyoming, Stati Uniti, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, Stati Uniti, 82801
- Welch Cancer Center
-
-
Criteri di partecipazione
Criteri di ammissibilità
Età idonea allo studio
Accetta volontari sani
Sessi ammissibili allo studio
Descrizione
Inclusion Criteria:
-
STEP 1: Age >= 18 years
-
STEP 1: Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
-
STEP 1: Patients must have oropharynx cancer (American Joint Committee on Cancer [AJCC] 8) that is p16-positive by immunohistochemistry OR p16 equivocal by IHC and HPV positive by in situ hybridization with the following criteria: >= 10 pack-years, stage T1-2N2-N3 or T3-4N0-3 (less than 10 pack-years is considered a non-smoker) OR < 10 pack-years, stage T4N0-N3 or T1-3N2-3
-
STEP 1: Patients must not have known hypersensitivity to nivolumab or compounds of similar chemical or biologic composition.
-
STEP 1: Patients with a history of allergic reactions attributed to platinum-based chemotherapy agents are excluded.
-
STEP 1: Patients must not have had prior systemic therapy, radiation treatment or surgery for p16 positive oropharyngeal squamous cell carcinoma (OPSCC).
- NOTE: Patients who had resection of T1 or T2 carcinoma with no radiation or chemotherapy are eligible if surgery was done 5 years prior to enrollment
-
STEP 1: Patients must not have received previous irradiation for head and neck tumor, skull base, or brain tumors.
-
STEP 1: Patients must not receive investigational agents within 4 weeks of enrollment or at any time while on study.
-
STEP 1: Patients with evidence of distant metastases or leptomeningeal disease (LMD) are excluded.
-
STEP 1: Patients with uncontrolled inter-current illnesses which in the opinion of the investigator will interfere with the ability to undergo therapy including chemotherapy are excluded.
-
STEP 1: Patients with a history of prior or second malignancy are excluded, with the exception of curatively treated non-melanoma skin cancer, or curatively treated cervical cancer; additionally, patients curatively treated for malignancy who remain disease-free at > 2 years of follow up, are not excluded.
-
STEP 1: Absolute neutrophil count (ANC) >= 1500/mm^3 (must be obtained =< 2 weeks prior to randomization).
-
STEP 1: Hemoglobin (Hgb) >= 8.0 g/dL (must be obtained =< 2 weeks prior to randomization).
-
STEP 1: Platelet count >= 100,000/mm^3 (must be obtained =< 2 weeks prior to randomization).
-
STEP 1: Creatinine clearance of >= 60 ml/min (must be obtained =< 2 weeks prior to randomization). Creatinine clearance may be measured or calculated. If calculating, creatinine clearance, use the Cockcroft-Gault formula.
-
STEP 1: Total bilirubin within 1.5 times the normal limits (must be obtained =< 2 weeks prior to randomization).
-
STEP 1: Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) or serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) within 2.0 times the normal limits (must be obtained =< 2 weeks prior to randomization).
-
STEP 1: Alkaline phosphatase within 2.0 times the normal limits (must be obtained =< 2 weeks prior to randomization).
-
STEP 1: Patients must not be pregnant or breast-feeding as chemotherapy, radiation, and immunotherapy may have possible teratogenicity effects; in addition, complications from pregnancy may interfere with the ability of patients to have an uninterrupted therapy. All patients of childbearing potential must have a blood test or urine study within 2 weeks prior to randomization to rule out pregnancy. A patient of childbearing potential is any patient, regardless of whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months).
-
STEP 1: Patients of childbearing potential must use an accepted and effective method of contraception or abstain from sexual intercourse for at least one week prior to the start of treatment, and continue for 5 months after the last dose of protocol treatment. Patients must also not donate ova during this same time period.
-
STEP 1: Patients must have measurable disease
-
STEP 1: Patients must have tumor measurements with CT of neck and CT of chest (or CT of neck and FDG PET/CT if standard of care) within 4 weeks prior to Step 1 randomization.
-
STEP 1: Patients with active autoimmune disease or history of autoimmune disease that might recur, which may affect vital organ function or require immune suppressive treatment including systemic corticosteroids, should be excluded. These include but are not limited to patients with a history of immune related neurologic disease, multiple sclerosis, autoimmune (demyelinating) neuropathy, Guillain-Barre syndrome, myasthenia gravis; systemic autoimmune disease such as systemic lupus erythematosus (SLE), connective tissue disease, scleroderma, inflammatory bowel disease (IBD), Crohn's, ulcerative colitis, hepatitis; and patients with a history of toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome, or phospholipid syndrome should be excluded because of the risk of recurrence or exacerbation of disease. Patients with vitiligo, endocrine deficiencies including thyroiditis managed with replacement hormones including physiologic corticosteroids are eligible. Patients with rheumatoid arthritis and other arthropathies, Sjogren's syndrome and psoriasis controlled with topical medication and patients with positive serology, such as antinuclear antibodies (ANA), anti-thyroid antibodies should be evaluated for the presence of target organ involvement and potential need for systemic treatment but should otherwise be eligible.
-
STEP 1: Patients are permitted to enroll if they have vitiligo, type I diabetes mellitus, residual hypothyroidism due to autoimmune condition only requiring hormone replacement, psoriasis not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger (precipitating event).
-
STEP 1: Patients must not have a condition requiring systemic treatment with either corticosteroids (> 10 mg/day prednisone equivalents) or other immunosuppressive medications which are expected to continue during nivolumab administration. Inhaled or topical steroids and adrenal replacement doses > 10 mg/day prednisone equivalents are permitted in the absence of active autoimmune disease
-
STEP 1: Patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated
-
STEP 1: Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load
-
STEP 1: Patients with a known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) must have no detectable viral load on a stable antiviral regimen
-
STEP 1: Patients must not be receiving any other investigational agents.
-
STEP 1: Patient must not have a baseline clinically significant hearing loss, which in the opinion of the investigator would preclude the use of cisplatin
-
STEP 2: Patients must have progression per RECIST criteria AND tissue-proven progression on Arm B treatment within 12 months after completion of radiation therapy.
-
STEP 2: ECOG performance status of 0 or 1.
-
STEP 2: Patients must not have known hypersensitivity to nivolumab or compounds of similar chemical or biologic composition.
-
STEP 2: Patients must not have received non-protocol anti-cancer therapy after completion of radiation and chemotherapy.
-
STEP 2: ANC >= 1500/mm^3 (must be obtained =< 2 weeks prior to registration).
-
STEP 2: Hgb >= 8.0 g/dL (must be obtained =< 2 weeks prior to registration).
-
STEP 2: Platelet count >= 100,000/mm^3 (must be obtained =< 2 weeks prior to registration).
-
STEP 2: Creatinine within institutional limits of normal (must be obtained =< 2 weeks prior to registration)
-
STEP 2: Total bilirubin within 1.5 times the normal limits (must be obtained =< 2 weeks prior to registration).
-
STEP 2: SGOT (AST) or SGPT (ALT) within 2.0 times the normal limits (must be obtained =< 2 weeks prior to registration).
-
STEP 2: Alkaline phosphatase within 1.5 times the normal limits (must be obtained =< 2 weeks prior to registration).
-
STEP 2: Patients must not be pregnant or breast-feeding as chemotherapy, radiation, and immunotherapy may have possible teratogenicity effects; in addition, complications from pregnancy may interfere with the ability of patients to have an uninterrupted therapy. All patients of childbearing potential must have a blood test or urine study within 2 weeks prior to registration to rule out pregnancy. A patient of childbearing potential is any patient, regardless of whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months).
-
STEP 2: Patients of childbearing potential must use an accepted and effective method of contraception or abstain from sexual intercourse for at least one week prior to the start of treatment, and continue for 5 months after the last dose of protocol treatment. Patients must also not donate ova during this same time period.
-
STEP 2: Patients must have measurable disease at the time of documented progression
- NOTE: For patients that have undergone salvage surgery for disease recurrence, measurable disease is not required at the time of registration to Step 2
-
STEP 2: Patients must have tumor measurements with CT of neck and CT of chest (or CT of neck and FDG PET/CT if standard of care) within 4 weeks prior to Step 2 registration
- NOTE: Patients that have undergone salvage surgery for disease recurrence prior to Step 2 are not required to have measurable disease post-resection, but must have CT of neck and CT of chest (or CT of neck and FDG PET/CT if standard of care) after salvage surgery and within 4 weeks prior to step 2 registration to establish a baseline prior to nivolumab
Piano di studio
Come è strutturato lo studio?
Dettagli di progettazione
- Scopo principale: Trattamento
- Assegnazione: Randomizzato
- Modello interventistico: Assegnazione incrociata
- Mascheramento: Nessuno (etichetta aperta)
Armi e interventi
Gruppo di partecipanti / Arm |
Intervento / Trattamento |
|---|---|
|
Sperimentale: Arm A (cisplatin, IMRT, nivolumab)
Patients receive cisplatin IV over 60 minutes weekly and IMRT 5 days a week for 7 weeks for a total of 35 fractions. Within 4 weeks after completion of concurrent therapy, patients receive nivolumab IV once weekly over 30 minutes every 4 weeks for 12 months in the absence of disease progression or unacceptable toxicity. Patients undergo CT or FDG PET/CT scans throughout the trial. Patients may undergo ECHO as clinically indicated. Additionally, patients undergo blood sample collection during screening. |
Given IV
Altri nomi:
Undergo blood sample collection
Altri nomi:
Undergo ECHO
Altri nomi:
Given IV
Altri nomi:
Undergo CT or PET/CT
Altri nomi:
Undergo PET/CT
Altri nomi:
Undergo IMRT
Altri nomi:
Receive FDG
Altri nomi:
|
|
Comparatore attivo: Arm B (cisplatin, IMRT, observation)
Patients receive cisplatin IV over 60 minutes weekly and IMRT 5 days a week for 7 weeks for a total of 35 fractions, and then go on observation. Patients will be offered the option to cross-over to Arm C if they have clearly documented progression within 12 months from the end of cisplatin/radiation therapy. Patients undergo CT or FDG PET/CT scans throughout the trial. Patients may undergo ECHO as clinically indicated. Additionally, patients undergo blood sample collection during screening. |
Given IV
Altri nomi:
Undergo blood sample collection
Altri nomi:
Undergo ECHO
Altri nomi:
Undergo CT or PET/CT
Altri nomi:
Undergo PET/CT
Altri nomi:
Undergo IMRT
Altri nomi:
Undergo observation
Altri nomi:
Receive FDG
Altri nomi:
|
|
Sperimentale: Arm C (nivolumab)
Patients receive nivolumab IV over 30 minutes every 4 weeks for 12 months in the absence of disease progression or unacceptable toxicity. Patients undergo CT or FDG PET/CT scans throughout the trial. Patients may undergo ECHO as clinically indicated. Additionally, patients undergo blood sample collection during screening. |
Undergo blood sample collection
Altri nomi:
Undergo ECHO
Altri nomi:
Given IV
Altri nomi:
Undergo CT or PET/CT
Altri nomi:
Undergo PET/CT
Altri nomi:
Receive FDG
Altri nomi:
|
Cosa sta misurando lo studio?
Misure di risultato primarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
|
Overall survival (OS)
Lasso di tempo: From randomization to death, assessed up to 10 years
|
Log rank test will be used to compare OS. As patients on the observation arm are allowed to cross-over to the nivolumab arm upon progression, an overall survival analysis using inverse probability censoring weights (IPCW, Robins et. al, 2000) will also be considered. Kaplan-Meier method and Cox regression will be used for the survival outcome analyses. |
From randomization to death, assessed up to 10 years
|
|
Negative (standardized qualitative) 12 week post therapy (cisplatin + radiation therapy [RT]) FDG positron emission tomography/computed tomography (PET/CT) associated with OS for patients who have a PET/CT
Lasso di tempo: At 12 weeks post therapy
|
Logrank tests and input hazard rates will be used. |
At 12 weeks post therapy
|
|
Negative (standardized qualitative) 12 week post therapy (cisplatin + RT) FDG PET/CT associated with PFS for patients who have a PET/CT
Lasso di tempo: At 12 weeks post therapy
|
Logrank tests and input hazard rates will be used. |
At 12 weeks post therapy
|
Misure di risultato secondarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
|
Progression-free survival (PFS)
Lasso di tempo: From randomization to date of progression, second primary tumor from the head and neck region, or death, assessed up to 10 years
|
Progression will be defined using Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria. The comparison of PFS will use stratified log rank test and will be intent-to-treat analyses. |
From randomization to date of progression, second primary tumor from the head and neck region, or death, assessed up to 10 years
|
|
Prognostic effect of baseline PD-L1 expression (positive versus [vs.] negative) on OS and PFS
Lasso di tempo: Baseline up to 10 years
|
Chi-square testing or Pearson correlation testing will be used for the secondary correlation analyses. |
Baseline up to 10 years
|
|
Prognostic effect of baseline saliva and/or plasma human papillomavirus (HPV) status (positive vs. negative) on OS and PFS
Lasso di tempo: Baseline up to 10 years
|
Saliva and plasma HPV status at 12 weeks and 9 months following completion of concurrent therapy will also be analyzed regarding effect on outcome. Chi-square testing or Pearson correlation testing will be used for the secondary correlation analyses. |
Baseline up to 10 years
|
|
Prognostic value of maximum standardized uptake value (SUVmax) of primary tumor or neck nodal metastasis of baseline FDG PET/CT for OS
Lasso di tempo: Baseline up to 10 years
|
Chi-square testing or Pearson correlation testing will be used for the secondary correlation analyses. |
Baseline up to 10 years
|
|
Prognostic value of SUVmax of primary tumor or neck nodal metastasis of baseline FDG PET/CT for PFS
Lasso di tempo: Baseline up to 10 years
|
Chi-square testing or Pearson correlation testing will be used for the secondary correlation analyses. |
Baseline up to 10 years
|
|
SUVmax of primary tumor or nodal metastasis of baseline FDG PET/CT with PD-L1 expression (positive vs. negative)
Lasso di tempo: Baseline up to 10 years
|
Chi-square testing or Pearson correlation testing will be used for the secondary correlation analyses. |
Baseline up to 10 years
|
|
Post therapy (cisplatin + RT) FDG PET/CT with saliva or plasma levels of HPV deoxyribonucleic acid (DNA)
Lasso di tempo: Up to 9 months post-therapy
|
Chi-square testing or Pearson correlation testing will be used for the secondary correlation analyses. |
Up to 9 months post-therapy
|
|
PET based therapy response assessment compared to RECIST 1.1 assessment for patients who have a PET/CT scan at 12 weeks
Lasso di tempo: At 12 weeks post chemoradiation therapy
|
Kappa statistics will be applied to evaluate the agreement between PET based therapy response assessment (Hopkins criteria) and RECIST 1.1 assessment at 12 weeks post chemoradiation therapy. |
At 12 weeks post chemoradiation therapy
|
Collaboratori e investigatori
Sponsor
Investigatori
- Investigatore principale: Nabil F Saba, ECOG-ACRIN Cancer Research Group
Studiare le date dei record
Studia le date principali
Inizio studio (Effettivo)
Completamento primario (Stimato)
Completamento dello studio (Stimato)
Date di iscrizione allo studio
Primo inviato
Primo inviato che soddisfa i criteri di controllo qualità
Primo Inserito (Effettivo)
Aggiornamenti dei record di studio
Ultimo aggiornamento pubblicato (Effettivo)
Ultimo aggiornamento inviato che soddisfa i criteri QC
Ultimo verificato
Maggiori informazioni
Termini relativi a questo studio
Termini MeSH pertinenti aggiuntivi
- Malattie stomatognatiche
- Neoplasie per sede
- Neoplasie
- Neoplasie della testa e del collo
- Malattie otorinolaringoiatriche
- Neoplasie faringee
- Neoplasie otorinolaringoiatriche
- Malattie faringee
- Neoplasie orofaringee
- Amministrazione dei servizi sanitari
- Aminoacidi, peptidi e proteine
- Proteine
- Tecniche investigative
- Metodi
- Terapie
- Tecniche di laboratorio clinico
- Tecniche e procedure diagnostiche
- Diagnosi
- Qualità dell'assistenza sanitaria
- Carboidrati
- Anticorpi, monoclonali, umanizzati
- Anticorpi, monoclonali
- Anticorpi
- Immunoglobuline
- Immunoproteine
- Proteine del sangue
- Globuline sieriche
- Globuline
- Prodotti chimici inorganici
- Composti di cloro
- Composti di azoto
- Elementi
- Metalli
- Tecniche di chimica, analitiche
- Analisi dello spettro
- Metalli, pesante
- Composti di platino
- Radioterapia
- Deossiglucosio
- Zuccheri di desossi
- Valutazione dei risultati, assistenza sanitaria
- Esito e valutazione del processo, assistenza sanitaria
- Elementi di transizione
- Radioterapia, conforme
- Radioterapia, assistita da computer
- Nivolumab
- Fluorodesossiglucosio F18
- Cisplatino
- 1,2-diamminocicloesaneplatino II citrato
- Osservazione
- Gestione dei campioni
- Spettroscopia di risonanza magnetica
- Aspetta vigile
- Platino
- Radioterapia, modulata intensità
Altri numeri di identificazione dello studio
- NCI-2019-00179
- U10CA180820 (Sovvenzione/contratto NIH degli Stati Uniti)
- NCI-2019-00179 (Identificatore di registro: CTRP (Clinical Trial Reporting Program))
- EA3161 (Altro identificatore: CTEP)
- EA3161 (Altro identificatore: ECOG-ACRIN Cancer Research Group)
Piano per i dati dei singoli partecipanti (IPD)
Hai intenzione di condividere i dati dei singoli partecipanti (IPD)?
Descrizione del piano IPD
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Informazioni su farmaci e dispositivi, documenti di studio
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Studia un dispositivo regolamentato dalla FDA degli Stati Uniti
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