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100-Year Human Aging Study

9. června 2026 aktualizováno: William Brandenburg, MD, Longevity Metrics, Inc.

100-Year Human Aging Study: Prospective Longitudinal Validation of Multi-System Health Measurements Against Mortality and Aging Outcomes

The 100-Year Human Aging Study is a prospective, pragmatic, observational trial enrolling participants across fixed and mobile clinical sites to undergo comprehensive multi-system health screening and longitudinal follow-up until death. Participants are followed to determine whether measurements taken at enrollment and repeated across the lifespan - individually and in combination - predict all-cause mortality, cause-specific mortality, incident serious disease, and functional disability. The study is designed to generate the surrogate endpoint validation data that longevity medicine currently lacks.

Přehled studie

Postavení

Nábor

Podmínky

Intervence / Léčba

Diagnostický test: Comprehensive Multi-System Clinical Screening

Detailní popis

All currently existing longevity measures are surrogate endpoints that have not been prospectively validated against actual mortality and aging outcomes. The 100-Year Human Aging Study is a prospective, pragmatic, observational trial that addresses this gap by enrolling participants in comprehensive clinical screening and following them longitudinally until death to determine which measurements - alone and in combination - are predictive of mortality, serious disease, and functional disability.

The study prioritizes dynamic measurements: the physiological, cognitive, social, and environmental capacities that change with aging and are most likely to carry predictive signal for mortality and functional outcomes. These include cardiorespiratory fitness (cardiopulmonary exercise testing with ventilatory threshold analysis), strength (grip, explosive power, functional movement), mobility and balance, neurocognitive performance, sensory function (vision, hearing, smell, light touch), and metabolic function (oral glucose tolerance, continuous glucose monitoring), in addition to other testing. Structural and imaging assessments include body composition and bone mineral density by DEXA, echocardiography, resting and stress electrocardiography, spirometry, retinal fundus photography, and vascular ultrasound. Laboratory measures are drawn on-site and processed through a CLIA-certified reference laboratory. Complete medical, surgical, family, social, occupational, and environmental histories are obtained at each visit.

Participation ranges from single-service visits - including standalone DEXA, cardiopulmonary exercise testing, laboratory panel testing, and sleep studies - to the full two-visit comprehensive screening battery. All participation pathways contribute clinical data to the longitudinal mortality and aging outcomes linkage framework regardless of service level. Participants are encouraged to return for repeat testing to build longitudinal health trajectories across the lifespan.

At enrollment and across longitudinal follow-up, the study platform generates individualized investigational constructs including biological age estimate, predicted death age, and predicted cause of death profile. These are explicitly investigational hypotheses, not validated clinical standards. Their predictive validity relative to actual mortality, aging outcomes, and functional disability is a central scientific question this study is designed to answer, both for individual measures and for composite multi-system models.

All data are archived in their highest-dimensional raw form to preserve the ability to apply future analytical methods retroactively. Participants are followed with periodic contact and offered repeat screening throughout the lifespan. Longitudinal outcomes ascertainment includes all-cause mortality, cause-specific mortality, incident serious health events, chronic disease diagnosis, functional independence, disability status, and health behavior change.

Typ studie

Pozorovací

Zápis (Odhadovaný)

1000000

Kontakty a umístění

Tato část poskytuje kontaktní údaje pro ty, kteří studii provádějí, a informace o tom, kde se tato studie provádí.

Studijní kontakt

Jméno: William E Brandenburg, MD
Telefonní číslo: 3035010016
E-mail: info@longevitymetrics.org

Studijní místa

Spojené státy
- Colorado
  - Boulder, Colorado, Spojené státy, 80301
    - Nábor
    - Longevity Metrics
    - Kontakt:
      
      William E Brandenburg, MD
      
      Telefonní číslo: 3035010016
      
      E-mail: info@longevitymetrics.org

Kritéria účasti

Výzkumníci hledají lidi, kteří odpovídají určitému popisu, kterému se říká kritéria způsobilosti. Některé příklady těchto kritérií jsou celkový zdravotní stav osoby nebo předchozí léčba.

Kritéria způsobilosti

Věk způsobilý ke studiu

Dospělý
Starší dospělý

Přijímá zdravé dobrovolníky

Ano

Metoda odběru vzorků

Vzorek nepravděpodobnosti

Studijní populace

Participants of all ages, health statuses, and demographic backgrounds presenting for comprehensive preventive health screening at fixed or mobile clinical sites. No exclusions based on health status, geographic location, language, or population group. Participants with limited decision-making capacity may be enrolled with consent from a legally authorized representative. The study actively seeks to enroll participants across the full human lifespan including older adults and centenarians.

Popis

Inclusion Criteria:

Age 18 years or older
Willing and able to provide written informed consent, or enrollment with consent of a legally authorized representative
Willing to participate in longitudinal follow-up

Exclusion Criteria:

Age under 18 years

Studijní plán

Tato část poskytuje podrobnosti o studijním plánu, včetně toho, jak je studie navržena a co studie měří.

Jak je studie koncipována?

Detaily designu

Co je měření studie?

Primární výstupní opatření

Měření výsledku	Popis opatření	Časové okno
All-Cause Mortality Časové okno: From enrollment until death, assessed periodically, up to 100 years	Vital status ascertained through longitudinal follow-up contact, mortality record linkage, and health data network linkage using probabilistic matching on name, date of birth, and address history.	From enrollment until death, assessed periodically, up to 100 years
Cause-Specific Mortality Časové okno: From enrollment until death, assessed periodically, up to 100 years	Cause of death ascertained via death certificate and mortality record linkage.	From enrollment until death, assessed periodically, up to 100 years

Sekundární výstupní opatření

Měření výsledku	Popis opatření	Časové okno
Cause-Specific Mortality Prediction Accuracy Časové okno: From enrollment until death, assessed periodically, up to 100 years	Concordance between predicted cause of death profile generated at enrollment and actual cause of death ascertained at follow-up.	From enrollment until death, assessed periodically, up to 100 years
Incident Serious Adverse Health Events Časové okno: Periodically from enrollment until death, up to 100 years	New diagnosis of myocardial infarction, stroke, cancer, dementia, heart failure, atrial fibrillation, sepsis, venous thromboembolism, COPD, chronic hypoxia, or major fracture ascertained via periodic follow-up contact and health data network linkage.	Periodically from enrollment until death, up to 100 years
Incident Chronic Disease Časové okno: Periodically from enrollment until death, up to 100 years	New diagnosis of type 2 diabetes, hypertension, COPD, chronic kidney disease, metabolic syndrome, or osteoporosis ascertained via self-report and health data network linkage.	Periodically from enrollment until death, up to 100 years
Functional Independence and Disability Status Časové okno: Periodically from enrollment until death, up to 100 years	Activities of daily living, instrumental activities of daily living, and self-reported disability status ascertained via periodic health survey using validated open-source instruments. Higher composite scores indicate greater functional independence. Specific instruments will be selected prior to first follow-up contact and documented in the statistical analysis plan.	Periodically from enrollment until death, up to 100 years
Biological Age Estimate Prediction Accuracy Časové okno: Periodically from enrollment until death, up to 100 years	Concordance between investigational biological age estimate and actual mortality outcomes at longitudinal follow-up.	Periodically from enrollment until death, up to 100 years
Health Behavior Change: Composite Self-Report and Repeat Screening Index Časové okno: Periodically from enrollment until death, up to 100 years	Health behavior change assessed through two complementary measures aggregated into a single index: validated composite self-report survey administered at periodic follow-up, and change in pre-specified clinical measurements at repeat screening. Improvement in objective clinical measurements (cardiorespiratory fitness, body composition, metabolic biomarkers, and related parameters) serves as the primary behavioral activation signal. Self-report domains including health behaviors and preventive care utilization provide supporting context. Both are combined into a single participant-level health activation index. Higher scores indicate greater engagement with health-promoting behaviors and measurable clinical improvement.	Periodically from enrollment until death, up to 100 years
Multi-System Predictor Modeling: Concordance Statistic Časové okno: Periodically from enrollment until death, up to 100 years	Predictive model performance quantified by concordance statistic (C-statistic) assessing the accuracy of a unified multi-domain measurement framework in predicting all-cause mortality and incident serious disease. The framework integrates clinical, biological, behavioral, social, occupational, and environmental data into a single composite predictive model. Analyses are reported as a single C-statistic for the full composite model, with pre-specified secondary reporting of C-statistics for individual predictor domains and domain combinations to identify which inputs are independently predictive, redundant, or synergistic. All analyses converge on the same unit of measure and the same outcome endpoints.	Periodically from enrollment until death, up to 100 years

Spolupracovníci a vyšetřovatelé

Zde najdete lidi a organizace zapojené do této studie.

Sponzor

Longevity Metrics, Inc.

Vyšetřovatelé

Vrchní vyšetřovatel: William E Brandenburg, MD, Longevity Metrics, Inc.

Publikace a užitečné odkazy

Osoba odpovědná za zadávání informací o studiu tyto publikace poskytuje dobrovolně. Mohou se týkat čehokoli, co souvisí se studiem.

Užitečné odkazy

study website

Termíny studijních záznamů

Tato data sledují průběh záznamů studie a předkládání souhrnných výsledků na ClinicalTrials.gov. Záznamy ze studií a hlášené výsledky jsou před zveřejněním na veřejné webové stránce přezkoumány Národní lékařskou knihovnou (NLM), aby se ujistily, že splňují specifické standardy kontroly kvality.

Hlavní termíny studia

Začátek studia (Aktuální)

9. února 2025

Primární dokončení (Odhadovaný)

31. prosince 2099

Dokončení studie (Odhadovaný)

31. prosince 2099

Termíny zápisu do studia

První předloženo

11. dubna 2026

První předloženo, které splnilo kritéria kontroly kvality

30. dubna 2026

První zveřejněno (Aktuální)

4. května 2026

Aktualizace studijních záznamů

Poslední zveřejněná aktualizace (Aktuální)

11. června 2026

Odeslaná poslední aktualizace, která splnila kritéria kontroly kvality

9. června 2026

Naposledy ověřeno

1. června 2026

Více informací

Termíny související s touto studií

Klíčová slova

Další relevantní podmínky MeSH

Další identifikační čísla studie

100Year
IORG0012336 (Jiný identifikátor: OHRP)
IRB00014601 (Jiný identifikátor: OHRP)

Plán pro data jednotlivých účastníků (IPD)

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Informace o lécích a zařízeních, studijní dokumenty

Studuje lékový produkt regulovaný americkým FDA

Studuje produkt zařízení regulovaný americkým úřadem FDA

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100-Year Human Aging Study