Efficacy of Digital Cognitive Behavioral Therapy for Insomnia (CBT-I) Utilizing Embodied Artificial Intelligence Agent in Virtual Reality
8. července 2026 aktualizováno: Tim M. H. Li, Chinese University of Hong Kong
Efficacy of Digital Cognitive Behavioral Therapy for Insomnia (CBT-I) Utilizing Embodied Artificial Intelligence Agent in Virtual Reality: A Randomized Controlled Trial
The goal of this clinical trial is to evaluate whether a virtually embodied artificial intelligence (AI) agent delivered via VR-enhanced digital cognitive behavioral therapy for insomnia (dCBT-I) can improve insomnia outcomes and treatment adherence in adults with insomnia.
The main questions it aims to answer are:
- Does VR-enhanced dCBT-I with an embodied AI agent lead to greater improvements in insomnia symptoms compared to app-based dCBT-I with an AI chatbot at post-intervention and 3-month follow-up?
Researchers will compare VR-enhanced dCBT-I with an embodied AI agent to app-based dCBT-I with an AI chatbot to see if the VR-enhanced intervention results in significantly improved clinical outcomes and adherence.
Participants will:
- Be randomly assigned to either the VR-enhanced AI agent intervention group or the app-based AI chatbot control group
- Complete a digital cognitive behavioral therapy for insomnia (dCBT-I) program with either a virtually embodied AI agent (VR-based) or a chatbot-based application
- Undergo assessments at baseline, post-intervention, and 3-month follow-up
Přehled studie
Postavení
Zatím nenabíráme
Podmínky
Typ studie
Intervenční
Zápis (Odhadovaný)
168
Fáze
- Nelze použít
Kontakty a umístění
Tato část poskytuje kontaktní údaje pro ty, kteří studii provádějí, a informace o tom, kde se tato studie provádí.
Studijní kontakt
- Jméno: Dr. Tim MH LI
- Telefonní číslo: +852 61150322
- E-mail: manholi@cuhk.edu.hk
Studijní místa
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Hong Kong, Hongkong
- 7/F, Sleep Assessment Unit, Shatin Hospital, 33 A Kung Kok Street, Ma On Shan, New Territories
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Kontakt:
- Dr. Tim MH LI
- Telefonní číslo: +852 61150322
- E-mail: manholi@cuhk.edu.hk
-
-
Kritéria účasti
Výzkumníci hledají lidi, kteří odpovídají určitému popisu, kterému se říká kritéria způsobilosti. Některé příklady těchto kritérií jsou celkový zdravotní stav osoby nebo předchozí léčba.
Kritéria způsobilosti
Věk způsobilý ke studiu
- Dospělý
- Starší dospělý
Přijímá zdravé dobrovolníky
Ne
Popis
Inclusion Criteria:
- Adults of Chinese ethnicity, aged between 18 and 65 years.
- Presence of insomnia, as indicated by a score of 10 or higher on the ISI.
- Meeting the DSM-IV-TR diagnostic criteria for insomnia disorder. The 1-month duration criterion in DSM-IV-TR rather than the 3-month criterion in DSM-V is adopted to broaden the clinical relevance of the study findings.
- Willing to provide online informed consent to participate in the study.
- Willing to comply with the requirements outlined in the study protocol.
- Possession of a smartphone and consistent internet access for smartphone use.
- Acceptance of the terms of service and privacy policies of the mobile apps used for intervention delivery.
Exclusion Criteria:
- A current or history of any sleep disorders other than insomnia disorder, such as narcolepsy, obstructive sleep apnea, and restless legs syndrome.
- A current or history of mental retardation or neuropsychiatric disorders other than depression or anxiety or stress disorders (as they are considered treatment outcomes), including bipolar disorder, schizophrenia, and substance use disorder.
- Presence of serious suicidality, demonstrated by ideation with a plan or a previous suicide attempt.
- Currently receiving long-term pharmacological treatment, including sleep-promoting agents.
- Currently undergoing structured psychotherapy.
- A current or history of significant visual, auditory, or balance impairment.
- A current or history of epilepsy
- Subject who is preparing for pregnancy or pregnant
- A current or history of any voice, speech, language disorders and learning difficulties.
- A current or history of severe health conditions (e.g., stroke, heart attack)
- Engaged in shiftwork or trans-meridian travel within the past 3 months or during the study.
Studijní plán
Tato část poskytuje podrobnosti o studijním plánu, včetně toho, jak je studie navržena a co studie měří.
Jak je studie koncipována?
Detaily designu
- Primární účel: Podpůrná péče
- Přidělení: Randomizované
- Intervenční model: Paralelní přiřazení
- Maskování: Singl
Zbraně a zásahy
Skupina účastníků / Arm |
Intervence / Léčba |
|---|---|
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Experimentální: App-based dCBT-I with AI chatbot
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Digital cognitive behavioral therapy for insomnia with two-way interactive, intelligent, and text-based conversational agents
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Aktivní komparátor: VR-enhanced dCBT-I with embodied AI agent
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Digital cognitive behavioral therapy for insomnia delivered in virtual reality with a two-way interactive, virtually embodied, and intelligent AI agent.
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Co je měření studie?
Primární výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
|---|---|---|
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Insomnia Severity Index
Časové okno: a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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the severity of insomnia symptoms
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a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
|
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Insomnia Module in the Diagnostic Interview for Sleep Disorder (DISP)
Časové okno: a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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the severity of insomnia symptoms
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a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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Sekundární výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
|---|---|---|
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Sleep onset latency (SOL)
Časové okno: a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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7-day sleep diary
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a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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Wake after sleep onset (WASO)
Časové okno: a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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7-day sleep diary
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a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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Sleep efficiency (SE)
Časové okno: a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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7-day sleep diary
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a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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Total sleep time (TST)
Časové okno: a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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7-day sleep diary
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a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
|
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The Pre-Sleep Arousal Scale
Časové okno: a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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cognitive and somatic manifestations of arousal near bedtime Total score ranges from 8 to 40.
Higher scores suggest increased cognitive and somatic arousal before sleep.
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a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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Ford Insomnia Response to Stress Test
Časové okno: a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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personal vulnerability to stress-related insomnia Total score ranges from 9 to 36.
Higher scores suggest a greater likelihood of stress-induced insomnia.
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a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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Reduced Morningness and Eveningness Questionnaire
Časové okno: a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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Chronotype preference.
Total score ranges from 4 to 25.
Higher scores suggest a morning chronotype, while lower scores indicate an evening chronotype.
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a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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The Dysfunctional Beliefs and Attitudes about Sleep Scale
Časové okno: a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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Faulty sleep-related beliefs and cognitions, which are cognitive aspects typically involved in the maintenance of insomnia.
Total score range of 0 to 160, with higher scores indicating stronger dysfunctional beliefs about sleep.
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a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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Depression, Anxiety and Stress Scale - 21 Items
Časové okno: a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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The DASS-21 contains 21 items in three subscales, which assess symptoms of depression, anxiety, and stress
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a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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Patient Health Questionnaire-9
Časové okno: a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
|
The severity of depressive symptoms.
Total score range of 0 to 27, where higher scores signify higher levels of depressive symptoms.
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a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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General Anxiety Disorder-7
Časové okno: a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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The severity of anxiety symptoms.
Total score range of 0 to 21, with higher scores reflecting higher levels of anxiety symptoms
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a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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The Sleep Hygiene Index
Časové okno: a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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The practice of sleep hygiene behaviors.
Total score ranges from 0 to 52.
Higher scores reflect poorer sleep hygiene practices.
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a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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The Multidimensional Fatigue Inventory
Časové okno: a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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Five dimensions of fatigue (general fatigue, physical fatigues, mental fatigue, decreased motivation, and decreased activities).
Total score ranges from 20 to 100.
Higher scores indicate greater fatigue levels.
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a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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Sleep Self-Efficiency Scale
Časové okno: a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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A 9-item scale evaluating abilities such as falling asleep quickly, returning to sleep after waking, and preventing a poor night's sleep from disrupting daily activities.
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a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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Revised Attitudes Toward Internet Questionnaire
Časové okno: a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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evaluates users' psychological, behavioral, and emotional responses to being online.
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a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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Credibility and expectancy questionnaire
Časové okno: a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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measure a participant's treatment credibility and outcome expectancy in therapy.
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a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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Motivation to Change Sleep Behaviors questionnaire
Časové okno: a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
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Assess the level of motivation to change sleep behaviors.
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a) baseline; b) post-intervention (1-month after baseline); c) 3-month after intervention (4-month after baseline)
|
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Acceptability E-scale questionnaire
Časové okno: post-intervention (1-month after baseline)
|
evaluate patients' impressions of computerized or e-health programs.
|
post-intervention (1-month after baseline)
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The Embodied Conversational Agents Trust Questionnaire
Časové okno: post-intervention (1-month after baseline)
|
measure a user's trust in a virtual agent or avatar.
It evaluates trust across two dimensions: perceived credibility and perceived benevolence.
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post-intervention (1-month after baseline)
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Adherence questionnaire
Časové okno: post-intervention (1-month after baseline)
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Assess the frequency of engagement in, and adherence to, the behavioral strategies and sleep-related recommendations taught during the program.
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post-intervention (1-month after baseline)
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User survey
Časové okno: post-intervention (1-month after baseline)
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Measure perceived system usability, safety, interactivity, personalization, and overall user experience.
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post-intervention (1-month after baseline)
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Spolupracovníci a vyšetřovatelé
Zde najdete lidi a organizace zapojené do této studie.
Sponzor
Termíny studijních záznamů
Tato data sledují průběh záznamů studie a předkládání souhrnných výsledků na ClinicalTrials.gov. Záznamy ze studií a hlášené výsledky jsou před zveřejněním na veřejné webové stránce přezkoumány Národní lékařskou knihovnou (NLM), aby se ujistily, že splňují specifické standardy kontroly kvality.
Hlavní termíny studia
Začátek studia (Odhadovaný)
23. října 2026
Primární dokončení (Odhadovaný)
30. září 2028
Dokončení studie (Odhadovaný)
22. dubna 2029
Termíny zápisu do studia
První předloženo
8. července 2026
První předloženo, které splnilo kritéria kontroly kvality
8. července 2026
První zveřejněno (Aktuální)
13. července 2026
Aktualizace studijních záznamů
Poslední zveřejněná aktualizace (Aktuální)
13. července 2026
Odeslaná poslední aktualizace, která splnila kritéria kontroly kvality
8. července 2026
Naposledy ověřeno
1. června 2026
Více informací
Termíny související s touto studií
Další relevantní podmínky MeSH
Další identifikační čísla studie
- 2025.771
- 23242231 (Jiné číslo grantu/financování: Health and Medical Research Fund - Health Bureau)
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