A Study on Associations Between Multidimensional Human Phenotypic Traits and Human Growth and Development
This observational study aims to investigate the associations between multidimensional human phenotypic characteristics and growth and developmental features. A total of 500 participants aged 6 to 60 years are planned to be enrolled. Multidimensional phenotypic characteristics will be assessed using non-invasive methods, including fingerprint imaging, foot morphology assessment, facial and tongue feature acquisition, anthropometric measurements, and musculoskeletal examinations. Development-related musculoskeletal characteristics, including plantar arch morphology, lower-limb alignment, joint range of motion, and generalized joint mobility, will also be assessed. The collected data will be analyzed to explore associations between external phenotypic characteristics and musculoskeletal growth and developmental features.
Přehled studie
Postavení
Intervence / Léčba
Detailní popis
Primary Objective:
The primary objective of this study is to investigate the associations between multidimensional human phenotypic characteristics and musculoskeletal growth and developmental features. Multidimensional phenotypic data will be collected using non-invasive assessment methods. Fingerprint characteristics will be obtained using high-resolution fingerprint imaging and characterized according to dermatoglyphic patterns and quantitative features. Foot morphology and plantar arch characteristics will be assessed using three-dimensional foot scanning. Facial and tongue features will be acquired using standardized digital imaging methods. Anthropometric characteristics and joint range of motion will also be measured using standardized procedures.
Musculoskeletal growth and developmental characteristics will be evaluated through physical examination and quantitative measurements. These assessments will include plantar arch morphology, lower-limb alignment, joint range of motion, and generalized joint mobility assessed using the Beighton score. Associations between multidimensional phenotypic characteristics and these musculoskeletal developmental features will be examined using appropriate statistical methods.
Secondary Objective:
The secondary objective is to explore whether combinations of multidimensional phenotypic characteristics are associated with specific patterns of musculoskeletal growth and development. The study will integrate fingerprint, foot, facial and tongue, anthropometric, and musculoskeletal data to investigate potential relationships among different phenotypic dimensions. Exploratory multivariable and machine-learning analyses may be used to identify combinations of phenotypic features associated with musculoskeletal developmental characteristics.
Typ studie
Zápis (Odhadovaný)
Kontakty a umístění
Studijní kontakt
- Jméno: Chao Chen
- Telefonní číslo: 86+13580348819
- E-mail: chenchao@smu.edu.cn
Studijní místa
-
-
Guangdong
-
Guangzhou, Guangdong, Čína, 510515
- Nábor
- Nanfang Hospital, Southern Medical University
-
Kontakt:
- YiJian Li, PhD
- Telefonní číslo: +86-20-62787238
- E-mail: nfyyec@163.com
-
Vrchní vyšetřovatel:
- Chao Chen, PhD
-
-
Kritéria účasti
Kritéria způsobilosti
Věk způsobilý ke studiu
Přijímá zdravé dobrovolníky
Pohlaví způsobilá ke studiu
Metoda odběru vzorků
Studijní populace
Participants will be young adults aged 18 to 25 years recruited primarily from university populations. Eligible participants will undergo standardized assessments of dermatoglyphic, facial, foot, anthropometric, limb proportional, and joint mobility characteristics.
Popis
Inclusion Criteria:
- Aged 18 to60 years.
- Able to understand the study procedures and provide informed consent.
- Willing and able to complete the required phenotypic assessments and measurements.
Exclusion Criteria:
- History of surgery that may affect musculoskeletal morphology or function.
- Known congenital or developmental disorders that may affect physical growth, limb development, or musculoskeletal morphology.
- Unable to complete the required study assessments.
Studijní plán
Jak je studie koncipována?
Detaily designu
- Observační modely: COHORT
- Časové perspektivy: CROSS_SECTIONAL
Kohorty a intervence
Skupina / kohorta |
Intervence / Léčba |
|---|---|
|
Adult Group
Adult participants aged 18 to 60 years who undergo multidimensional phenotypic assessments, including fingerprint imaging, foot morphology assessment, facial and tongue feature acquisition, anthropometric measurements, joint range of motion assessment, and evaluation of generalized joint mobility and other musculoskeletal developmental characteristics. |
Fingerprint images of all ten fingers will be collected using a high-resolution fingerprint scanner. Dermatoglyphic characteristics, including fingerprint pattern types (arch, loop, and whorl), total ridge counts, and ridge counts of individual fingers, will be quantitatively and qualitatively assessed. These naturally occurring phenotypic characteristics are observed and measured only, with no intervention assigned to participants. |
|
Minor Group
Participants aged 6 to 17 years who undergo multidimensional phenotypic assessments, including fingerprint imaging, foot morphology assessment, facial and tongue feature acquisition, anthropometric measurements, joint range of motion assessment, and evaluation of generalized joint mobility and other musculoskeletal developmental characteristics. |
Fingerprint images of all ten fingers will be collected using a high-resolution fingerprint scanner. Dermatoglyphic characteristics, including fingerprint pattern types (arch, loop, and whorl), total ridge counts, and ridge counts of individual fingers, will be quantitatively and qualitatively assessed. These naturally occurring phenotypic characteristics are observed and measured only, with no intervention assigned to participants. |
Co je měření studie?
Primární výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
|---|---|---|
|
Foot Arch Morphology Assessed by Arch Index
Časové okno: Baseline
|
Foot arch morphology will be assessed using the Arch Index derived from standardized foot measurements. The Arch Index will be used as a quantitative indicator of plantar arch morphology to characterize variations in foot development among participants. |
Baseline
|
|
Generalized Joint Hypermobility Assessed by Beighton Score
Časové okno: Baseline
|
Generalized joint hypermobility will be assessed using the 9-point Beighton scoring system. The total score ranges from 0 to 9, with higher scores indicating greater generalized joint hypermobility. |
Baseline
|
Sekundární výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
|---|---|---|
|
Anthropometric and Limb Proportional Measurements
Časové okno: Baseline
|
Anthropometric measurements, including height, body weight, upper- and lower-limb lengths, and other relevant body dimensions, will be collected using standardized measurement procedures. Limb proportional indices will be calculated to characterize individual differences in body and limb morphology. |
Baseline
|
|
Foot Morphological Characteristics
Časové okno: Baseline
|
Foot morphological characteristics will be assessed using standardized foot scanning and measurement procedures. Measures will include foot dimensions and morphological features derived from plantar and foot-shape data to characterize individual variations in foot morphology. |
Baseline
|
|
Fingerprint Dermatoglyphic Characteristics
Časové okno: Baseline
|
Fingerprint images will be collected using a standardized acquisition procedure. Dermatoglyphic characteristics, including fingerprint pattern types and other morphological features, will be extracted and analyzed to investigate their associations with foot morphology, limb proportions, and generalized joint hypermobility. |
Baseline
|
|
Facial Morphological Characteristics
Časové okno: Baseline
|
Standardized facial images will be collected under controlled acquisition conditions. Facial morphological characteristics and quantitative facial features will be extracted from the images to characterize individual variations in facial morphology and to investigate their associations with limb and musculoskeletal phenotypes. |
Baseline
|
Spolupracovníci a vyšetřovatelé
Publikace a užitečné odkazy
Obecné publikace
- Malek S, Reinhold EJ, Pearce GS. The Beighton Score as a measure of generalised joint hypermobility. Rheumatol Int. 2021 Oct;41(10):1707-1716. doi: 10.1007/s00296-021-04832-4. Epub 2021 Mar 18.
- Cavanagh PR, Rodgers MM. The arch index: a useful measure from footprints. J Biomech. 1987;20(5):547-51. doi: 10.1016/0021-9290(87)90255-7.
- Rothhammer F, Llop E, Neel JV. Dermatoglyphic characters and physique: a correlation study. Am J Phys Anthropol. 1982 Jan;57(1):99-101. doi: 10.1002/ajpa.1330570110.
- Livshits G, Kobyliansky E. Dermatoglyphic traits as possible markers of developmental processes in humans. Am J Med Genet. 1987 Jan;26(1):111-22. doi: 10.1002/ajmg.1320260118.
Termíny studijních záznamů
Hlavní termíny studia
Začátek studia (Odhadovaný)
Primární dokončení (Odhadovaný)
Dokončení studie (Odhadovaný)
Termíny zápisu do studia
První předloženo
První předloženo, které splnilo kritéria kontroly kvality
První zveřejněno (Aktuální)
Aktualizace studijních záznamů
Poslední zveřejněná aktualizace (Aktuální)
Odeslaná poslední aktualizace, která splnila kritéria kontroly kvality
Naposledy ověřeno
Více informací
Termíny související s touto studií
Klíčová slova
Další relevantní podmínky MeSH
Další identifikační čísla studie
- NFEC-2026-524
Plán pro data jednotlivých účastníků (IPD)
Plánujete sdílet data jednotlivých účastníků (IPD)?
Popis plánu IPD
Individual participant data will not be shared at this time due to concerns regarding participant privacy and confidentiality.
Informace o lécích a zařízeních, studijní dokumenty
Studuje lékový produkt regulovaný americkým FDA
Studuje produkt zařízení regulovaný americkým úřadem FDA
Tyto informace byly beze změn načteny přímo z webu clinicaltrials.gov. Máte-li jakékoli požadavky na změnu, odstranění nebo aktualizaci podrobností studie, kontaktujte prosím register@clinicaltrials.gov. Jakmile bude změna implementována na clinicaltrials.gov, bude automaticky aktualizována i na našem webu .