A Study on Associations Between Multidimensional Human Phenotypic Traits and Human Growth and Development
This observational study aims to investigate the associations between multidimensional human phenotypic characteristics and growth and developmental features. A total of 500 participants aged 6 to 60 years are planned to be enrolled. Multidimensional phenotypic characteristics will be assessed using non-invasive methods, including fingerprint imaging, foot morphology assessment, facial and tongue feature acquisition, anthropometric measurements, and musculoskeletal examinations. Development-related musculoskeletal characteristics, including plantar arch morphology, lower-limb alignment, joint range of motion, and generalized joint mobility, will also be assessed. The collected data will be analyzed to explore associations between external phenotypic characteristics and musculoskeletal growth and developmental features.
Studienübersicht
Status
Bedingungen
Intervention / Behandlung
Detaillierte Beschreibung
Primary Objective:
The primary objective of this study is to investigate the associations between multidimensional human phenotypic characteristics and musculoskeletal growth and developmental features. Multidimensional phenotypic data will be collected using non-invasive assessment methods. Fingerprint characteristics will be obtained using high-resolution fingerprint imaging and characterized according to dermatoglyphic patterns and quantitative features. Foot morphology and plantar arch characteristics will be assessed using three-dimensional foot scanning. Facial and tongue features will be acquired using standardized digital imaging methods. Anthropometric characteristics and joint range of motion will also be measured using standardized procedures.
Musculoskeletal growth and developmental characteristics will be evaluated through physical examination and quantitative measurements. These assessments will include plantar arch morphology, lower-limb alignment, joint range of motion, and generalized joint mobility assessed using the Beighton score. Associations between multidimensional phenotypic characteristics and these musculoskeletal developmental features will be examined using appropriate statistical methods.
Secondary Objective:
The secondary objective is to explore whether combinations of multidimensional phenotypic characteristics are associated with specific patterns of musculoskeletal growth and development. The study will integrate fingerprint, foot, facial and tongue, anthropometric, and musculoskeletal data to investigate potential relationships among different phenotypic dimensions. Exploratory multivariable and machine-learning analyses may be used to identify combinations of phenotypic features associated with musculoskeletal developmental characteristics.
Studientyp
Einschreibung (Geschätzt)
Kontakte und Standorte
Studienkontakt
- Name: Chao Chen
- Telefonnummer: 86+13580348819
- E-Mail: chenchao@smu.edu.cn
Studienorte
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Guangdong
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Guangzhou, Guangdong, China, 510515
- Rekrutierung
- Nanfang Hospital, Southern Medical University
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Kontakt:
- YiJian Li, PhD
- Telefonnummer: +86-20-62787238
- E-Mail: nfyyec@163.com
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Hauptermittler:
- Chao Chen, PhD
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Teilnahmekriterien
Zulassungskriterien
Studienberechtigtes Alter
Akzeptiert gesunde Freiwillige
Studienberechtigte Geschlechter
Probenahmeverfahren
Studienpopulation
Participants will be young adults aged 18 to 25 years recruited primarily from university populations. Eligible participants will undergo standardized assessments of dermatoglyphic, facial, foot, anthropometric, limb proportional, and joint mobility characteristics.
Beschreibung
Inclusion Criteria:
- Aged 18 to60 years.
- Able to understand the study procedures and provide informed consent.
- Willing and able to complete the required phenotypic assessments and measurements.
Exclusion Criteria:
- History of surgery that may affect musculoskeletal morphology or function.
- Known congenital or developmental disorders that may affect physical growth, limb development, or musculoskeletal morphology.
- Unable to complete the required study assessments.
Studienplan
Wie ist die Studie aufgebaut?
Designdetails
- Beobachtungsmodelle: COHORT
- Zeitperspektiven: CROSS_SECTIONAL
Kohorten und Interventionen
Gruppe / Kohorte |
Intervention / Behandlung |
|---|---|
|
Adult Group
Adult participants aged 18 to 60 years who undergo multidimensional phenotypic assessments, including fingerprint imaging, foot morphology assessment, facial and tongue feature acquisition, anthropometric measurements, joint range of motion assessment, and evaluation of generalized joint mobility and other musculoskeletal developmental characteristics. |
Fingerprint images of all ten fingers will be collected using a high-resolution fingerprint scanner. Dermatoglyphic characteristics, including fingerprint pattern types (arch, loop, and whorl), total ridge counts, and ridge counts of individual fingers, will be quantitatively and qualitatively assessed. These naturally occurring phenotypic characteristics are observed and measured only, with no intervention assigned to participants. |
|
Minor Group
Participants aged 6 to 17 years who undergo multidimensional phenotypic assessments, including fingerprint imaging, foot morphology assessment, facial and tongue feature acquisition, anthropometric measurements, joint range of motion assessment, and evaluation of generalized joint mobility and other musculoskeletal developmental characteristics. |
Fingerprint images of all ten fingers will be collected using a high-resolution fingerprint scanner. Dermatoglyphic characteristics, including fingerprint pattern types (arch, loop, and whorl), total ridge counts, and ridge counts of individual fingers, will be quantitatively and qualitatively assessed. These naturally occurring phenotypic characteristics are observed and measured only, with no intervention assigned to participants. |
Was misst die Studie?
Primäre Ergebnismessungen
Ergebnis Maßnahme |
Maßnahmenbeschreibung |
Zeitfenster |
|---|---|---|
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Foot Arch Morphology Assessed by Arch Index
Zeitfenster: Baseline
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Foot arch morphology will be assessed using the Arch Index derived from standardized foot measurements. The Arch Index will be used as a quantitative indicator of plantar arch morphology to characterize variations in foot development among participants. |
Baseline
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Generalized Joint Hypermobility Assessed by Beighton Score
Zeitfenster: Baseline
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Generalized joint hypermobility will be assessed using the 9-point Beighton scoring system. The total score ranges from 0 to 9, with higher scores indicating greater generalized joint hypermobility. |
Baseline
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Sekundäre Ergebnismessungen
Ergebnis Maßnahme |
Maßnahmenbeschreibung |
Zeitfenster |
|---|---|---|
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Anthropometric and Limb Proportional Measurements
Zeitfenster: Baseline
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Anthropometric measurements, including height, body weight, upper- and lower-limb lengths, and other relevant body dimensions, will be collected using standardized measurement procedures. Limb proportional indices will be calculated to characterize individual differences in body and limb morphology. |
Baseline
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Foot Morphological Characteristics
Zeitfenster: Baseline
|
Foot morphological characteristics will be assessed using standardized foot scanning and measurement procedures. Measures will include foot dimensions and morphological features derived from plantar and foot-shape data to characterize individual variations in foot morphology. |
Baseline
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Fingerprint Dermatoglyphic Characteristics
Zeitfenster: Baseline
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Fingerprint images will be collected using a standardized acquisition procedure. Dermatoglyphic characteristics, including fingerprint pattern types and other morphological features, will be extracted and analyzed to investigate their associations with foot morphology, limb proportions, and generalized joint hypermobility. |
Baseline
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Facial Morphological Characteristics
Zeitfenster: Baseline
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Standardized facial images will be collected under controlled acquisition conditions. Facial morphological characteristics and quantitative facial features will be extracted from the images to characterize individual variations in facial morphology and to investigate their associations with limb and musculoskeletal phenotypes. |
Baseline
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Mitarbeiter und Ermittler
Publikationen und hilfreiche Links
Allgemeine Veröffentlichungen
- Malek S, Reinhold EJ, Pearce GS. The Beighton Score as a measure of generalised joint hypermobility. Rheumatol Int. 2021 Oct;41(10):1707-1716. doi: 10.1007/s00296-021-04832-4. Epub 2021 Mar 18.
- Cavanagh PR, Rodgers MM. The arch index: a useful measure from footprints. J Biomech. 1987;20(5):547-51. doi: 10.1016/0021-9290(87)90255-7.
- Rothhammer F, Llop E, Neel JV. Dermatoglyphic characters and physique: a correlation study. Am J Phys Anthropol. 1982 Jan;57(1):99-101. doi: 10.1002/ajpa.1330570110.
- Livshits G, Kobyliansky E. Dermatoglyphic traits as possible markers of developmental processes in humans. Am J Med Genet. 1987 Jan;26(1):111-22. doi: 10.1002/ajmg.1320260118.
Studienaufzeichnungsdaten
Haupttermine studieren
Studienbeginn (Geschätzt)
Primärer Abschluss (Geschätzt)
Studienabschluss (Geschätzt)
Studienanmeldedaten
Zuerst eingereicht
Zuerst eingereicht, das die QC-Kriterien erfüllt hat
Zuerst gepostet (Tatsächlich)
Studienaufzeichnungsaktualisierungen
Letztes Update gepostet (Tatsächlich)
Letztes eingereichtes Update, das die QC-Kriterien erfüllt
Zuletzt verifiziert
Mehr Informationen
Begriffe im Zusammenhang mit dieser Studie
Schlüsselwörter
Zusätzliche relevante MeSH-Bedingungen
Andere Studien-ID-Nummern
- NFEC-2026-524
Plan für individuelle Teilnehmerdaten (IPD)
Planen Sie, individuelle Teilnehmerdaten (IPD) zu teilen?
Beschreibung des IPD-Plans
Individual participant data will not be shared at this time due to concerns regarding participant privacy and confidentiality.
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Studiert ein von der US-amerikanischen FDA reguliertes Arzneimittelprodukt
Studiert ein von der US-amerikanischen FDA reguliertes Geräteprodukt
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