A Study on Associations Between Multidimensional Human Phenotypic Traits and Human Growth and Development
This observational study aims to investigate the associations between multidimensional human phenotypic characteristics and growth and developmental features. A total of 500 participants aged 6 to 60 years are planned to be enrolled. Multidimensional phenotypic characteristics will be assessed using non-invasive methods, including fingerprint imaging, foot morphology assessment, facial and tongue feature acquisition, anthropometric measurements, and musculoskeletal examinations. Development-related musculoskeletal characteristics, including plantar arch morphology, lower-limb alignment, joint range of motion, and generalized joint mobility, will also be assessed. The collected data will be analyzed to explore associations between external phenotypic characteristics and musculoskeletal growth and developmental features.
Przegląd badań
Status
Interwencja / Leczenie
Szczegółowy opis
Primary Objective:
The primary objective of this study is to investigate the associations between multidimensional human phenotypic characteristics and musculoskeletal growth and developmental features. Multidimensional phenotypic data will be collected using non-invasive assessment methods. Fingerprint characteristics will be obtained using high-resolution fingerprint imaging and characterized according to dermatoglyphic patterns and quantitative features. Foot morphology and plantar arch characteristics will be assessed using three-dimensional foot scanning. Facial and tongue features will be acquired using standardized digital imaging methods. Anthropometric characteristics and joint range of motion will also be measured using standardized procedures.
Musculoskeletal growth and developmental characteristics will be evaluated through physical examination and quantitative measurements. These assessments will include plantar arch morphology, lower-limb alignment, joint range of motion, and generalized joint mobility assessed using the Beighton score. Associations between multidimensional phenotypic characteristics and these musculoskeletal developmental features will be examined using appropriate statistical methods.
Secondary Objective:
The secondary objective is to explore whether combinations of multidimensional phenotypic characteristics are associated with specific patterns of musculoskeletal growth and development. The study will integrate fingerprint, foot, facial and tongue, anthropometric, and musculoskeletal data to investigate potential relationships among different phenotypic dimensions. Exploratory multivariable and machine-learning analyses may be used to identify combinations of phenotypic features associated with musculoskeletal developmental characteristics.
Typ studiów
Zapisy (Szacowany)
Kontakty i lokalizacje
Kontakt w sprawie studiów
- Nazwa: Chao Chen
- Numer telefonu: 86+13580348819
- E-mail: chenchao@smu.edu.cn
Lokalizacje studiów
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Guangdong
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Guangzhou, Guangdong, Chiny, 510515
- Rekrutacyjny
- Nanfang Hospital, Southern Medical University
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Kontakt:
- YiJian Li, PhD
- Numer telefonu: +86-20-62787238
- E-mail: nfyyec@163.com
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Główny śledczy:
- Chao Chen, PhD
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Kryteria uczestnictwa
Kryteria kwalifikacji
Wiek uprawniający do nauki
Akceptuje zdrowych ochotników
Płeć kwalifikująca się do nauki
Metoda próbkowania
Badana populacja
Participants will be young adults aged 18 to 25 years recruited primarily from university populations. Eligible participants will undergo standardized assessments of dermatoglyphic, facial, foot, anthropometric, limb proportional, and joint mobility characteristics.
Opis
Inclusion Criteria:
- Aged 18 to60 years.
- Able to understand the study procedures and provide informed consent.
- Willing and able to complete the required phenotypic assessments and measurements.
Exclusion Criteria:
- History of surgery that may affect musculoskeletal morphology or function.
- Known congenital or developmental disorders that may affect physical growth, limb development, or musculoskeletal morphology.
- Unable to complete the required study assessments.
Plan studiów
Jak projektuje się badanie?
Szczegóły projektu
- Modele obserwacyjne: COHORT
- Perspektywy czasowe: CROSS_SECTIONAL
Kohorty i interwencje
Grupa / Kohorta |
Interwencja / Leczenie |
|---|---|
|
Adult Group
Adult participants aged 18 to 60 years who undergo multidimensional phenotypic assessments, including fingerprint imaging, foot morphology assessment, facial and tongue feature acquisition, anthropometric measurements, joint range of motion assessment, and evaluation of generalized joint mobility and other musculoskeletal developmental characteristics. |
Fingerprint images of all ten fingers will be collected using a high-resolution fingerprint scanner. Dermatoglyphic characteristics, including fingerprint pattern types (arch, loop, and whorl), total ridge counts, and ridge counts of individual fingers, will be quantitatively and qualitatively assessed. These naturally occurring phenotypic characteristics are observed and measured only, with no intervention assigned to participants. |
|
Minor Group
Participants aged 6 to 17 years who undergo multidimensional phenotypic assessments, including fingerprint imaging, foot morphology assessment, facial and tongue feature acquisition, anthropometric measurements, joint range of motion assessment, and evaluation of generalized joint mobility and other musculoskeletal developmental characteristics. |
Fingerprint images of all ten fingers will be collected using a high-resolution fingerprint scanner. Dermatoglyphic characteristics, including fingerprint pattern types (arch, loop, and whorl), total ridge counts, and ridge counts of individual fingers, will be quantitatively and qualitatively assessed. These naturally occurring phenotypic characteristics are observed and measured only, with no intervention assigned to participants. |
Co mierzy badanie?
Podstawowe miary wyniku
Miara wyniku |
Opis środka |
Ramy czasowe |
|---|---|---|
|
Foot Arch Morphology Assessed by Arch Index
Ramy czasowe: Baseline
|
Foot arch morphology will be assessed using the Arch Index derived from standardized foot measurements. The Arch Index will be used as a quantitative indicator of plantar arch morphology to characterize variations in foot development among participants. |
Baseline
|
|
Generalized Joint Hypermobility Assessed by Beighton Score
Ramy czasowe: Baseline
|
Generalized joint hypermobility will be assessed using the 9-point Beighton scoring system. The total score ranges from 0 to 9, with higher scores indicating greater generalized joint hypermobility. |
Baseline
|
Miary wyników drugorzędnych
Miara wyniku |
Opis środka |
Ramy czasowe |
|---|---|---|
|
Anthropometric and Limb Proportional Measurements
Ramy czasowe: Baseline
|
Anthropometric measurements, including height, body weight, upper- and lower-limb lengths, and other relevant body dimensions, will be collected using standardized measurement procedures. Limb proportional indices will be calculated to characterize individual differences in body and limb morphology. |
Baseline
|
|
Foot Morphological Characteristics
Ramy czasowe: Baseline
|
Foot morphological characteristics will be assessed using standardized foot scanning and measurement procedures. Measures will include foot dimensions and morphological features derived from plantar and foot-shape data to characterize individual variations in foot morphology. |
Baseline
|
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Fingerprint Dermatoglyphic Characteristics
Ramy czasowe: Baseline
|
Fingerprint images will be collected using a standardized acquisition procedure. Dermatoglyphic characteristics, including fingerprint pattern types and other morphological features, will be extracted and analyzed to investigate their associations with foot morphology, limb proportions, and generalized joint hypermobility. |
Baseline
|
|
Facial Morphological Characteristics
Ramy czasowe: Baseline
|
Standardized facial images will be collected under controlled acquisition conditions. Facial morphological characteristics and quantitative facial features will be extracted from the images to characterize individual variations in facial morphology and to investigate their associations with limb and musculoskeletal phenotypes. |
Baseline
|
Współpracownicy i badacze
Publikacje i pomocne linki
Publikacje ogólne
- Malek S, Reinhold EJ, Pearce GS. The Beighton Score as a measure of generalised joint hypermobility. Rheumatol Int. 2021 Oct;41(10):1707-1716. doi: 10.1007/s00296-021-04832-4. Epub 2021 Mar 18.
- Cavanagh PR, Rodgers MM. The arch index: a useful measure from footprints. J Biomech. 1987;20(5):547-51. doi: 10.1016/0021-9290(87)90255-7.
- Rothhammer F, Llop E, Neel JV. Dermatoglyphic characters and physique: a correlation study. Am J Phys Anthropol. 1982 Jan;57(1):99-101. doi: 10.1002/ajpa.1330570110.
- Livshits G, Kobyliansky E. Dermatoglyphic traits as possible markers of developmental processes in humans. Am J Med Genet. 1987 Jan;26(1):111-22. doi: 10.1002/ajmg.1320260118.
Daty zapisu na studia
Główne daty studiów
Rozpoczęcie studiów (Szacowany)
Zakończenie podstawowe (Szacowany)
Ukończenie studiów (Szacowany)
Daty rejestracji na studia
Pierwszy przesłany
Pierwszy przesłany, który spełnia kryteria kontroli jakości
Pierwszy wysłany (Rzeczywisty)
Aktualizacje rekordów badań
Ostatnia wysłana aktualizacja (Rzeczywisty)
Ostatnia przesłana aktualizacja, która spełniała kryteria kontroli jakości
Ostatnia weryfikacja
Więcej informacji
Terminy związane z tym badaniem
Słowa kluczowe
Dodatkowe istotne warunki MeSH
Inne numery identyfikacyjne badania
- NFEC-2026-524
Plan dla danych uczestnika indywidualnego (IPD)
Planujesz udostępniać dane poszczególnych uczestników (IPD)?
Opis planu IPD
Individual participant data will not be shared at this time due to concerns regarding participant privacy and confidentiality.
Informacje o lekach i urządzeniach, dokumenty badawcze
Bada produkt leczniczy regulowany przez amerykańską FDA
Bada produkt urządzenia regulowany przez amerykańską FDA
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