Vinorelbine in Treating Children With Recurrent or Refractory Cancers
25. juli 2014 opdateret af: Children's Oncology Group
A Phase II Study of Navelbine (Vinorelbine) In Children With Recurrent Or Refractory Malignancies
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of vinorelbine in treating children with recurrent or refractory cancer.
Studieoversigt
Status
Afsluttet
Intervention / Behandling
Detaljeret beskrivelse
OBJECTIVES: I. Determine the response rate of children with recurrent or refractory malignancies treated with vinorelbine. II. Assess the toxic effects of this drug in these children.
OUTLINE: Patients receive vinorelbine IV over 6-10 minutes weekly on weeks 1-6. Treatment repeats every 8 weeks for a total of 10 courses in the absence of disease progression or unacceptable toxicity. Patients are followed every 4 months for 2 years, every 6 months for 1 year, and then annually thereafter.
PROJECTED ACCRUAL: A maximum of 100 patients will be accrued for this study within 2 years.
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
50
Fase
- Fase 2
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
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New South Wales
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Randwick, New South Wales, Australien, 2031
- Sydney Children's Hospital
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Westmead, New South Wales, Australien, 2145
- Children's Hospital at Westmead
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Queensland
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Brisbane, Queensland, Australien, 4029
- Royal Children's Hospital
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Victoria
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Parkville, Victoria, Australien, 3052
- Royal Children's Hospital
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Western Australia
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Perth, Western Australia, Australien, 6001
- Princess Margaret Hospital for Children
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Alberta
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Calgary, Alberta, Canada, T2T 5C7
- Alberta Children's Hospital
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Edmonton, Alberta, Canada, T6G 1Z2
- Cross Cancer Institute
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British Columbia
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Vancouver, British Columbia, Canada, V6H 3V4
- British Columbia Children's Hospital
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Manitoba
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Winnipeg, Manitoba, Canada, R3E 0V9
- CancerCare Manitoba
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Newfoundland and Labrador
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St. John's, Newfoundland and Labrador, Canada, A1A 1R8
- Janeway Children's Health and Rehabilitation Centre
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Nova Scotia
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Halifax, Nova Scotia, Canada, B3J 3G9
- IWK Health Centre
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Ontario
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Hamilton, Ontario, Canada, L8N 3Z5
- Children's Hospital
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London, Ontario, Canada, N6C 2V5
- Children's Hospital of Western Ontario
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Ottawa, Ontario, Canada, K1H 8L1
- Children's Hospital of Eastern Ontario
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Toronto, Ontario, Canada, M5G 1X8
- Hospital for Sick Children
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Quebec
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Montreal, Quebec, Canada, H3T 1C5
- Hôpital Sainte Justine
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Montreal, Quebec, Canada, H3H 1P3
- McGill University Health Center - Montreal Children's Hospital
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Sainte Foy, Quebec, Canada, GIV 4G2
- Centre Hospitalier de l'Université Laval
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Sainte-Foy, Quebec, Canada, G1V 4G2
- Laval University Medical Center
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Saskatchewan
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Regina, Saskatchewan, Canada, S4T 7T1
- Allan Blair Cancer Centre
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Saskatoon, Saskatchewan, Canada, S7N 4H4
- Saskatoon Cancer Centre
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Alabama
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Birmingham, Alabama, Forenede Stater, 35294-3300
- University of Alabama at Birmingham Comprehensive Cancer Center
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Mobile, Alabama, Forenede Stater, 36617-2293
- University of South Alabama Medical Center
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Arizona
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Phoenix, Arizona, Forenede Stater, 85006
- Phoenix Children's Hospital
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Tucson, Arizona, Forenede Stater, 85724
- Arizona Cancer Center
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Arkansas
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Little Rock, Arkansas, Forenede Stater, 72205
- University of Arkansas for Medical Sciences
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California
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Downey, California, Forenede Stater, 90242
- Southern California Permanente Medical Group
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Duarte, California, Forenede Stater, 91010-3000
- Cancer Center and Beckman Research Institute, City of Hope
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La Jolla, California, Forenede Stater, 92093-0658
- University of California San Diego Cancer Center
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Loma Linda, California, Forenede Stater, 92354
- Loma Linda University Medical Center
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Long Beach, California, Forenede Stater, 90801-1428
- Jonathan Jaques Children'S Cancer Center
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Los Angeles, California, Forenede Stater, 90048
- Cedars-Sinai Medical Center
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Los Angeles, California, Forenede Stater, 90095-1781
- Jonsson Comprehensive Cancer Center, UCLA
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Los Angeles, California, Forenede Stater, 90027-0700
- Children's Hospital Los Angeles
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Madera, California, Forenede Stater, 93638
- Valley Children's Hospital
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Oakland, California, Forenede Stater, 94609
- Children's Hospital of Oakland
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Orange, California, Forenede Stater, 92868
- Chao Family Comprehensive Cancer Center
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Orange, California, Forenede Stater, 92868
- Children's Hospital of Orange County
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Palo Alto, California, Forenede Stater, 94304
- Lucile Packard Children's Hospital at Stanford
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Sacramento, California, Forenede Stater, 95816
- Sutter Cancer Center
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Sacramento, California, Forenede Stater, 95817
- University of California Davis Medical Center
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San Diego, California, Forenede Stater, 92120
- Kaiser Permanente-Southern California Permanente Medical Group
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San Diego, California, Forenede Stater, 92123-4282
- Children's Hospital and Health Center
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San Francisco, California, Forenede Stater, 94143-0128
- UCSF Cancer Center and Cancer Research Institute
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San Francisco, California, Forenede Stater, 94115
- Kaiser Permanente Medical Group - San Francisco
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Santa Barbara, California, Forenede Stater, 93102
- Santa Barbara Cottage Hospital
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Santa Clara, California, Forenede Stater, 95051-5386
- Kaiser Permanente Medical Center - Santa Clara
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Travis Air Force Base, California, Forenede Stater, 94535
- David Grant Medical Center
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Colorado
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Denver, Colorado, Forenede Stater, 80218
- Childhood Hematology/Oncology Associates
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Denver, Colorado, Forenede Stater, 80218
- Presbyterian-St Luke's Medical Center
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Denver, Colorado, Forenede Stater, 80218
- Children's Hospital of Denver
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Connecticut
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Farmington, Connecticut, Forenede Stater, 06360-7106
- University of Connecticut Health Center
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New Haven, Connecticut, Forenede Stater, 06520-8028
- Yale Comprehensive Cancer Center
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Delaware
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Wilmington, Delaware, Forenede Stater, 19899
- Alfred I. Dupont Institute
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District of Columbia
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Washington, District of Columbia, Forenede Stater, 20307-5000
- Walter Reed Army Medical Center
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Washington, District of Columbia, Forenede Stater, 20010-2970
- Children's National Medical Center
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Washington, District of Columbia, Forenede Stater, 20007
- Lombardi Cancer Center
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Florida
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Fort Lauderdale, Florida, Forenede Stater, 33316
- Broward General Medical Center
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Fort Myers, Florida, Forenede Stater, 33908
- Children's Hospital of Southwest Florida
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Gainesville, Florida, Forenede Stater, 32610-100277
- Shands Hospital and Clinics, University of Florida
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Hollywood, Florida, Forenede Stater, 33021
- Joe DiMaggio Children's Hospital at Memorial
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Jacksonville, Florida, Forenede Stater, 32207
- Nemours Children's Clinic
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Miami, Florida, Forenede Stater, 33176-2197
- Baptist Hospital of Miami
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Miami, Florida, Forenede Stater, 33155
- Miami Children's Hospital
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Miami, Florida, Forenede Stater, 33136
- University of Miami-Jackson Memorial Hospital Medical Center
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Orlando, Florida, Forenede Stater, 32803
- Walt Disney Memorial Cancer Institute
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Orlando, Florida, Forenede Stater, 32806
- Nemours Children's Clinic-Orlando
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Pensacola, Florida, Forenede Stater, 32504
- Sacred Heart Children's Hospital
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St. Petersburg, Florida, Forenede Stater, 33701
- All Children's Hospital
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Tampa, Florida, Forenede Stater, 33677-4227
- Tampa Children's Hospital
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West Palm Beach, Florida, Forenede Stater, 33407
- St. Mary's Hospital
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Georgia
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Atlanta, Georgia, Forenede Stater, 30322
- Emory University Hospital - Atlanta
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Atlanta, Georgia, Forenede Stater, 30342
- Children's Healthcare of Atlanta - Scottish Rite
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Augusta, Georgia, Forenede Stater, 30912-4000
- Medical College of Georgia Comprehensive Cancer Center
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Macon, Georgia, Forenede Stater, 31201
- Medical Center of Central Georgia
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Savannah, Georgia, Forenede Stater, 31403-3089
- Memorial Health University Medical Center, Inc.
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Hawaii
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Honolulu, Hawaii, Forenede Stater, 96859-5000
- Tripler Army Medical Center
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Honolulu, Hawaii, Forenede Stater, 96813
- Cancer Research Center of Hawaii
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Idaho
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Boise, Idaho, Forenede Stater, 83712
- Mountain States Tumor Institute
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Illinois
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Chicago, Illinois, Forenede Stater, 60612
- University of Illinois at Chicago
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Chicago, Illinois, Forenede Stater, 60637-1470
- University of Chicago Cancer Research Center
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Chicago, Illinois, Forenede Stater, 60612
- Rush-Presbyterian-St. Luke's Medical Center
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Chicago, Illinois, Forenede Stater, 60614
- Children's Memorial Hospital, Chicago
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Oak Lawn, Illinois, Forenede Stater, 60453
- Hope Children's Hospital
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Park Ridge, Illinois, Forenede Stater, 60068
- Lutheran General Hospital
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Peoria, Illinois, Forenede Stater, 61637
- Saint Jude Midwest Affiliate
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Rockford, Illinois, Forenede Stater, 61104
- University Child Health Services Clinic
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Springfield, Illinois, Forenede Stater, 62794-9230
- Southern Illinois University School of Medicine
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Indiana
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Indianapolis, Indiana, Forenede Stater, 46202-5289
- Indiana University Cancer Center
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Indianapolis, Indiana, Forenede Stater, 46260
- St. Vincent Hospital and Health Care Center
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Iowa
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Des Moines, Iowa, Forenede Stater, 50308
- Raymond Blank Memorial Hospital for Children
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Des Moines, Iowa, Forenede Stater, 50309
- John Stoddard Cancer Center
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Iowa City, Iowa, Forenede Stater, 52242-1009
- Holden Comprehensive Cancer Center at the University of Iowa
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Kansas
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Wichita, Kansas, Forenede Stater, 67214
- Wesley Medical Center
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Kentucky
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Lexington, Kentucky, Forenede Stater, 40536-0084
- Albert B. Chandler Medical Center, University of Kentucky
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Louisville, Kentucky, Forenede Stater, 40232
- Kosair Children's Hospital
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Louisiana
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New Orleans, Louisiana, Forenede Stater, 70112
- Tulane University School of Medicine
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New Orleans, Louisiana, Forenede Stater, 70118
- Children's Hospital of New Orleans
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New Orleans, Louisiana, Forenede Stater, 70121
- Ochsner Clinic
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Maine
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Bangor, Maine, Forenede Stater, 04401
- Eastern Maine Medical Center
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Scarborough, Maine, Forenede Stater, 04074
- Maine Children's Cancer Program
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Maryland
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Baltimore, Maryland, Forenede Stater, 21231-2410
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
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Baltimore, Maryland, Forenede Stater, 21201
- Marlene & Stewart Greenebaum Cancer Center, University of Maryland
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Baltimore, Maryland, Forenede Stater, 21225
- Sinai Hospital of Baltimore
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Massachusetts
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Boston, Massachusetts, Forenede Stater, 02115
- Dana-Farber Cancer Institute
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Boston, Massachusetts, Forenede Stater, 02111
- Boston Floating Hospital Infants and Children
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Springfield, Massachusetts, Forenede Stater, 01199
- Baystate Medical Center
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Worcester, Massachusetts, Forenede Stater, 01655
- University of Massachusetts Memorial Medical Center
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Michigan
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Ann Arbor, Michigan, Forenede Stater, 48109
- Mott Children's Hospital
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Detroit, Michigan, Forenede Stater, 48202
- Henry Ford Hospital
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Detroit, Michigan, Forenede Stater, 48201
- Children's Hospital of Michigan
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Detroit, Michigan, Forenede Stater, 48236
- St. John Hospital and Medical Center
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East Lansing, Michigan, Forenede Stater, 48824
- Michigan State University
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Flint, Michigan, Forenede Stater, 48503
- Hurley Medical Center
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Grand Rapids, Michigan, Forenede Stater, 49503
- Spectrum Health and DeVos Children's Hospital
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Kalamazoo, Michigan, Forenede Stater, 49007
- Bronson Methodist Hospital
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Royal Oak, Michigan, Forenede Stater, 48073
- William Beaumont Hospital
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Minnesota
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Duluth, Minnesota, Forenede Stater, 55805
- Duluth Clinic
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Minneapolis, Minnesota, Forenede Stater, 55404
- Children's Hospitals and Clinics - Minneapolis
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Rochester, Minnesota, Forenede Stater, 55905
- Mayo Clinic Cancer Center
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Saint Paul, Minnesota, Forenede Stater, 55102
- Children's Hospitals and Clinics of Minnesota
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Mississippi
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Jackson, Mississippi, Forenede Stater, 39216-4505
- University of Mississippi Medical Center
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Missouri
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Kansas City, Missouri, Forenede Stater, 64108
- Children's Mercy Hospital
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Saint Louis, Missouri, Forenede Stater, 63110
- St. Louis Children's Hospital
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Saint Louis, Missouri, Forenede Stater, 63104
- Cardinal Glennon Children's Hospital
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Nebraska
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Omaha, Nebraska, Forenede Stater, 68198-3330
- University of Nebraska Medical Center
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Omaha, Nebraska, Forenede Stater, 68114
- Children's Hospital of Omaha
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Nevada
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Las Vegas, Nevada, Forenede Stater, 89109-2306
- Sunrise Hospital and Medical Center
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New Hampshire
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Lebanon, New Hampshire, Forenede Stater, 03756-0002
- Norris Cotton Cancer Center
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New Jersey
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Hackensack, New Jersey, Forenede Stater, 07601
- Hackensack University Medical Center
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New Brunswick, New Jersey, Forenede Stater, 08901
- Cancer Institute Of New Jersey
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Newark, New Jersey, Forenede Stater, 07112
- Newark Beth Israel Medical Center
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Paterson, New Jersey, Forenede Stater, 07503
- St. Joseph's Hospital and Medical Center
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Summit, New Jersey, Forenede Stater, 07901
- Atlantic Health System
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New Mexico
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Albuquerque, New Mexico, Forenede Stater, 87131
- University of New Mexico School of Medicine
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New York
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Albany, New York, Forenede Stater, 12208
- Cancer Center of Albany Medical Center
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Bronx, New York, Forenede Stater, 10467-2490
- Montefiore Medical Center
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Brooklyn, New York, Forenede Stater, 11219
- Maimonides Medical Center
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Brooklyn, New York, Forenede Stater, 11201
- Brooklyn Hospital Center
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Brooklyn, New York, Forenede Stater, 11203
- State University of New York Health Science Center at Brooklyn College of Medicine
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Brooklyn, New York, Forenede Stater, 11212
- Brookdale University Hospital and Medical Center
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Buffalo, New York, Forenede Stater, 14263-0001
- Roswell Park Cancer Institute
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Manhasset, New York, Forenede Stater, 11030
- North Shore University Hospital
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New Hyde Park, New York, Forenede Stater, 11042
- Schneider Children's Hospital
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New York, New York, Forenede Stater, 10021
- Memorial Sloan-Kettering Cancer Center
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New York, New York, Forenede Stater, 10021
- New York Presbyterian Hospital - Cornell Campus
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New York, New York, Forenede Stater, 10029
- Mount Sinai School of Medicine
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New York, New York, Forenede Stater, 10032
- Columbia Presbyterian Hospital
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Rochester, New York, Forenede Stater, 14642
- University of Rochester Cancer Center
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Stony Brook, New York, Forenede Stater, 11790-7775
- State University of New York Health Sciences Center - Stony Brook
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Syracuse, New York, Forenede Stater, 13210
- State University of New York - Upstate Medical University
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Valhalla, New York, Forenede Stater, 10595
- New York Medical College
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North Carolina
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Asheville, North Carolina, Forenede Stater, 28801
- Mission Saint Joseph's Health System
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Chapel Hill, North Carolina, Forenede Stater, 27599-7295
- Lineberger Comprehensive Cancer Center, UNC
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Charlotte, North Carolina, Forenede Stater, 28232-2861
- Carolinas Medical Center
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Charlotte, North Carolina, Forenede Stater, 28233-3549
- Presbyterian Healthcare
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Durham, North Carolina, Forenede Stater, 27710
- Duke Comprehensive Cancer Center
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Greenville, North Carolina, Forenede Stater, 27858-4354
- East Carolina University School of Medicine
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North Dakota
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Fargo, North Dakota, Forenede Stater, 58108-6001
- Dakota Cancer Institute
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Ohio
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Akron, Ohio, Forenede Stater, 44308
- Children's Hospital Medical Center of Akron
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Cincinnati, Ohio, Forenede Stater, 45229-3039
- Children's Hospital Medical Center - Cincinnati
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Cleveland, Ohio, Forenede Stater, 44195
- Cleveland Clinic Taussig Cancer Center
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Cleveland, Ohio, Forenede Stater, 44106-5065
- Ireland Cancer Center
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Columbus, Ohio, Forenede Stater, 43205-2696
- Children's Hospital of Columbus
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Dayton, Ohio, Forenede Stater, 45404
- Children's Medical Center - Dayton
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Toledo, Ohio, Forenede Stater, 43601
- Toledo Children's Hospital
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Toledo, Ohio, Forenede Stater, 43608
- St. Vincent Mercy Medical Center
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Youngstown, Ohio, Forenede Stater, 44501
- Forum Health-Tod Childrens Hospital
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Oklahoma
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Oklahoma City, Oklahoma, Forenede Stater, 73104
- Children's Hospital of Oklahoma
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Tulsa, Oklahoma, Forenede Stater, 74136
- Natalie Warren Bryant Cancer Center
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Oregon
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Portland, Oregon, Forenede Stater, 97201-3098
- Doernbecher Children's Hospital
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Portland, Oregon, Forenede Stater, 97227
- Legacy Emanuel Hospital and Health Center
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Pennsylvania
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Danville, Pennsylvania, Forenede Stater, 17822-2001
- Geisinger Medical Center
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Hershey, Pennsylvania, Forenede Stater, 17033-0850
- Milton S. Hershey Medical Center
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Philadelphia, Pennsylvania, Forenede Stater, 19104
- Children's Hospital of Philadelphia
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Philadelphia, Pennsylvania, Forenede Stater, 19134-1095
- St. Christopher's Hospital for Children
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Pittsburgh, Pennsylvania, Forenede Stater, 15213
- Children's Hospital of Pittsburgh
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Rhode Island
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Providence, Rhode Island, Forenede Stater, 02903
- Rhode Island Hospital
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South Carolina
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Charleston, South Carolina, Forenede Stater, 29425-0721
- Medical University of South Carolina
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Columbia, South Carolina, Forenede Stater, 29203
- Center for Cancer Treatment and Research
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Greenville, South Carolina, Forenede Stater, 29605
- Children's Hospital of Greenville Hospital System
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South Dakota
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Sioux Falls, South Dakota, Forenede Stater, 57105
- Avera Cancer Institute
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Sioux Falls, South Dakota, Forenede Stater, 57117
- Sioux Valley Hospital
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Tennessee
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Johnson City, Tennessee, Forenede Stater, 37614-0622
- James H. Quillen College of Medicine
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Knoxville, Tennessee, Forenede Stater, 37901
- East Tennessee Children's Hospital
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Memphis, Tennessee, Forenede Stater, 38105-2794
- Saint Jude Children's Research Hospital
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Nashville, Tennessee, Forenede Stater, 37232-6838
- Vanderbilt-Ingram Cancer Center
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Texas
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Amarillo, Texas, Forenede Stater, 79106
- Texas Tech University Health Sciences Center School of Medicine
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Austin, Texas, Forenede Stater, 78701
- Children's Hospital of Austin
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Dallas, Texas, Forenede Stater, 75230
- Medical City Dallas Hospital
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Dallas, Texas, Forenede Stater, 75235-9154
- Simmons Cancer Center - Dallas
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Fort Worth, Texas, Forenede Stater, 76104
- Cook Children's Medical Center - Fort Worth
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Galveston, Texas, Forenede Stater, 77555-0209
- University of Texas Medical Branch
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Houston, Texas, Forenede Stater, 77030
- Baylor College of Medicine
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Houston, Texas, Forenede Stater, 77030-4009
- University of Texas - MD Anderson Cancer Center
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Lackland Air Force Base, Texas, Forenede Stater, 78236-5300
- San Antonio Military Pediatric Cancer and Blood Disorders Center
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Lubbock, Texas, Forenede Stater, 79410
- Covenant Children's Hospital
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San Antonio, Texas, Forenede Stater, 78284-7811
- University of Texas Health Science Center at San Antonio
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San Antonio, Texas, Forenede Stater, 78229
- Methodist Health Care System
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Temple, Texas, Forenede Stater, 76508
- Scott and White Memorial Hospital
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Vermont
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Burlington, Vermont, Forenede Stater, 05401-3498
- Vermont Cancer Center
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Virginia
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Charlottesville, Virginia, Forenede Stater, 22908
- Cancer Center at the University of Virginia
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Falls Church, Virginia, Forenede Stater, 22042-3300
- INOVA Fairfax Hospital
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Norfolk, Virginia, Forenede Stater, 23507
- Children's Hospital of The King's Daughters
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Portsmouth, Virginia, Forenede Stater, 23708-2197
- Naval Medical Center, Portsmouth
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Richmond, Virginia, Forenede Stater, 23298-0037
- Massey Cancer Center
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Roanoke, Virginia, Forenede Stater, 24013
- Carilion Roanoke Community Hospital
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Washington
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Seattle, Washington, Forenede Stater, 98105
- Children's Hospital and Regional Medical Center - Seattle
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Seattle, Washington, Forenede Stater, 98109-1024
- Fred Hutchinson Cancer Research Center
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Seattle, Washington, Forenede Stater, 98112
- Group Health Cooperative of Puget Sound
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Spokane, Washington, Forenede Stater, 99210-0248
- Deaconess Medical Center
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Tacoma, Washington, Forenede Stater, 98431-5000
- Madigan Army Medical Center
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Tacoma, Washington, Forenede Stater, 98405
- Mary Bridge Children's Health Center
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West Virginia
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Charleston, West Virginia, Forenede Stater, 25302
- West Virginia University - Charleston
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Huntington, West Virginia, Forenede Stater, 25701
- Cabell-Huntington Hospital, Inc
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Morgantown, West Virginia, Forenede Stater, 26506-9300
- West Virginia University Hospitals
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Wisconsin
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Green Bay, Wisconsin, Forenede Stater, 54307-3508
- St. Vincent Hospital
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Green Bay, Wisconsin, Forenede Stater, 54301
- Bellin Memorial Hospital
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La Crosse, Wisconsin, Forenede Stater, 54601
- Gundersen Lutheran Medical Center
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Madison, Wisconsin, Forenede Stater, 53792-0001
- University of Wisconsin Hospital and Clinics
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Milwaukee, Wisconsin, Forenede Stater, 53226
- Midwest Children's Cancer Center
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-
-
-
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Groningen, Holland, 9713 EZ
- Academisch Ziekenhuis Groningen
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-
-
-
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Auckland, New Zealand
- Starship Children's Hospital
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-
-
-
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San Juan, Puerto Rico, 00936-5067
- University of Puerto Rico School of Medicine Medical Sciences Campus
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Santurce, Puerto Rico, 00912
- San Jorge Childrens Hospital
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-
-
-
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Bern, Schweiz, CH 3010
- Swiss Pediatric Oncology Group Bern
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Geneva, Schweiz, CH 1211
- Swiss Pediatric Oncology Group Geneva
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Lausanne, Schweiz, CH 1011
- Swiss Pediatric Oncology Group Lausanne
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Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
Ikke ældre end 21 år (Barn, Voksen)
Tager imod sunde frivillige
Ingen
Køn, der er berettiget til at studere
Alle
Beskrivelse
DISEASE CHARACTERISTICS: Histologically confirmed recurrent or refractory solid malignant tumors of childhood including: Soft tissue sarcoma Rhabdomyosarcoma Nonrhabdomyosarcoma Extraosseous Ewing's sarcoma CNS tumors Astrocytoma Primitive neuroectodermal tumor Atypical teratoid/rhabdoid tumors Ependymoma Recurrent neuroblastoma Measurable disease No more than 2 prior treatment regimens
PATIENT CHARACTERISTICS: Age: 21 and under at diagnosis Performance status: ECOG 0-2 Life expectancy: At least 2 months Hematopoietic: For patients with solid tumors (unless marrow involvement): Absolute neutrophil count (ANC) at least 1000/mm3 Platelet count at least 100,000/mm3 (transfusion independent) Hemoglobin at least 10 g/dL (RBC transfusions allowed) For patients post bone marrow transplantation: ANC at least 1,000/mm3 Platelet count at least 50,000/mm3 (transfusion independent) Hemoglobin at least 10 g/dL (RBC transfusions allowed) Hepatic: Total bilirubin no greater than 1.5 times normal SGOT/SGPT less than 2.5 times normal Renal: Creatinine no greater than 1.5 times normal OR Creatinine clearance or radioisotope glomerular filtration rate at least 70 mL/min Neurologic: Seizure disorder allowed if well controlled CNS toxicity no greater than grade 2
PRIOR CONCURRENT THERAPY: Biologic therapy: At least 6 months since prior bone marrow transplantation No concurrent immunomodulating agents Chemotherapy: At least 2 weeks since prior chemotherapy (4 weeks for nitrosourea) and recovered No other concurrent chemotherapy Endocrine therapy: No concurrent corticosteroids except for increased intracranial pressure due to CNS tumors Radiotherapy: At least 6 months since prior radiotherapy to craniospinal axis, spine, and/or more than 50% of the bony pelvis Concurrent radiotherapy to localized painful lesions allowed if at least one measurable lesion is not in radiation field Surgery: Not specified Other: No concurrent participation in another CCG, POG, or COG therapeutic study
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
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Eksperimentel: Stratum 1 - Soft Tissue Sarcoma
See detailed description.
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Andre navne:
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Eksperimentel: Stratum 2 - CNS Tumors
See detailed description.
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Andre navne:
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Eksperimentel: Stratum 3 - Neuroblastoma
See detailed description.
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Andre navne:
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
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Sygdomsprogression
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Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Samarbejdspartnere
Efterforskere
- Studiestol: John F. Kuttesch, PhD, MD, M.D. Anderson Cancer Center
Publikationer og nyttige links
Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart
1. maj 1998
Primær færdiggørelse (Faktiske)
1. marts 2006
Studieafslutning (Faktiske)
1. marts 2007
Datoer for studieregistrering
Først indsendt
1. november 1999
Først indsendt, der opfyldte QC-kriterier
27. oktober 2003
Først opslået (Skøn)
28. oktober 2003
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
28. juli 2014
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
25. juli 2014
Sidst verificeret
1. juli 2014
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
- tilbagevendende rhabdomyosarkom i barndommen
- tilbagevendende neuroblastom
- tilbagevendende Ewing-sarkom/perifer primitiv neuroektodermal tumor
- tilbagevendende supratentorial primitiv neuroektodermal tumor i barndommen
- tilbagevendende cerebellar astrocytom i barndommen
- tilbagevendende cerebralt astrocytom i barndommen
- tilbagevendende barndoms ependymom
- tilbagevendende bløddelssarkom i barndommen
Yderligere relevante MeSH-vilkår
- Sygdomme i nervesystemet
- Neoplasmer, bindevæv og blødt væv
- Neoplasmer efter histologisk type
- Neoplasmer
- Neoplasmer efter sted
- Neoplasmer, kirtel og epitel
- Neoplasmer, Neuroepithelial
- Neuroektodermale tumorer
- Neoplasmer, kimceller og embryonale
- Neoplasmer, nervevæv
- Neuroektodermale tumorer, primitive
- Neuroektodermale tumorer, primitive, perifere
- Sarkom
- Neoplasmer i nervesystemet
- Neoplasmer i centralnervesystemet
- Neuroblastom
- Molekylære mekanismer for farmakologisk virkning
- Antineoplastiske midler
- Tubulin modulatorer
- Antimitotiske midler
- Mitose modulatorer
- Antineoplastiske midler, fytogene
- Vinorelbin
Andre undersøgelses-id-numre
- A09705
- COG-A09705 (Anden identifikator: Children's Oncology Group)
- CCG-09705 (Anden identifikator: Children's Cancer Group)
- CDR0000066106 (Anden identifikator: Clinical Trials.gov)
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .