Vinorelbine in Treating Children With Recurrent or Refractory Cancers
25 juli 2014 bijgewerkt door: Children's Oncology Group
A Phase II Study of Navelbine (Vinorelbine) In Children With Recurrent Or Refractory Malignancies
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of vinorelbine in treating children with recurrent or refractory cancer.
Studie Overzicht
Toestand
Voltooid
Interventie / Behandeling
Gedetailleerde beschrijving
OBJECTIVES: I. Determine the response rate of children with recurrent or refractory malignancies treated with vinorelbine. II. Assess the toxic effects of this drug in these children.
OUTLINE: Patients receive vinorelbine IV over 6-10 minutes weekly on weeks 1-6. Treatment repeats every 8 weeks for a total of 10 courses in the absence of disease progression or unacceptable toxicity. Patients are followed every 4 months for 2 years, every 6 months for 1 year, and then annually thereafter.
PROJECTED ACCRUAL: A maximum of 100 patients will be accrued for this study within 2 years.
Studietype
Ingrijpend
Inschrijving (Werkelijk)
50
Fase
- Fase 2
Contacten en locaties
In dit gedeelte vindt u de contactgegevens van degenen die het onderzoek uitvoeren en informatie over waar dit onderzoek wordt uitgevoerd.
Studie Locaties
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New South Wales
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Randwick, New South Wales, Australië, 2031
- Sydney Children's Hospital
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Westmead, New South Wales, Australië, 2145
- Children's Hospital at Westmead
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Queensland
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Brisbane, Queensland, Australië, 4029
- Royal Children's Hospital
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Victoria
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Parkville, Victoria, Australië, 3052
- Royal Children's Hospital
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Western Australia
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Perth, Western Australia, Australië, 6001
- Princess Margaret Hospital for Children
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Alberta
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Calgary, Alberta, Canada, T2T 5C7
- Alberta Children's Hospital
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Edmonton, Alberta, Canada, T6G 1Z2
- Cross Cancer Institute
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British Columbia
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Vancouver, British Columbia, Canada, V6H 3V4
- British Columbia Children's Hospital
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Manitoba
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Winnipeg, Manitoba, Canada, R3E 0V9
- CancerCare Manitoba
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Newfoundland and Labrador
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St. John's, Newfoundland and Labrador, Canada, A1A 1R8
- Janeway Children's Health and Rehabilitation Centre
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Nova Scotia
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Halifax, Nova Scotia, Canada, B3J 3G9
- IWK Health Centre
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Ontario
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Hamilton, Ontario, Canada, L8N 3Z5
- Children's Hospital
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London, Ontario, Canada, N6C 2V5
- Children's Hospital of Western Ontario
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Ottawa, Ontario, Canada, K1H 8L1
- Children's Hospital of Eastern Ontario
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Toronto, Ontario, Canada, M5G 1X8
- Hospital for Sick Children
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Quebec
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Montreal, Quebec, Canada, H3T 1C5
- Hopital Sainte Justine
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Montreal, Quebec, Canada, H3H 1P3
- McGill University Health Center - Montreal Children's Hospital
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Sainte Foy, Quebec, Canada, GIV 4G2
- Centre Hospitalier de l'Universite Laval
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Sainte-Foy, Quebec, Canada, G1V 4G2
- Laval University Medical Center
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Saskatchewan
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Regina, Saskatchewan, Canada, S4T 7T1
- Allan Blair Cancer Centre
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Saskatoon, Saskatchewan, Canada, S7N 4H4
- Saskatoon Cancer Centre
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Groningen, Nederland, 9713 EZ
- Academisch Ziekenhuis Groningen
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Auckland, Nieuw-Zeeland
- Starship Children's Hospital
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San Juan, Puerto Rico, 00936-5067
- University of Puerto Rico School of Medicine Medical Sciences Campus
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Santurce, Puerto Rico, 00912
- San Jorge Childrens Hospital
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Alabama
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Birmingham, Alabama, Verenigde Staten, 35294-3300
- University of Alabama at Birmingham Comprehensive Cancer Center
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Mobile, Alabama, Verenigde Staten, 36617-2293
- University of South Alabama Medical Center
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Arizona
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Phoenix, Arizona, Verenigde Staten, 85006
- Phoenix Children's Hospital
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Tucson, Arizona, Verenigde Staten, 85724
- Arizona Cancer Center
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Arkansas
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Little Rock, Arkansas, Verenigde Staten, 72205
- University of Arkansas for Medical Sciences
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California
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Downey, California, Verenigde Staten, 90242
- Southern California Permanente Medical Group
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Duarte, California, Verenigde Staten, 91010-3000
- Cancer Center and Beckman Research Institute, City of Hope
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La Jolla, California, Verenigde Staten, 92093-0658
- University of California San Diego Cancer Center
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Loma Linda, California, Verenigde Staten, 92354
- Loma Linda University Medical Center
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Long Beach, California, Verenigde Staten, 90801-1428
- Jonathan Jaques Children'S Cancer Center
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Los Angeles, California, Verenigde Staten, 90048
- Cedars-Sinai Medical Center
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Los Angeles, California, Verenigde Staten, 90095-1781
- Jonsson Comprehensive Cancer Center, UCLA
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Los Angeles, California, Verenigde Staten, 90027-0700
- Children's Hospital Los Angeles
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Madera, California, Verenigde Staten, 93638
- Valley Children's Hospital
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Oakland, California, Verenigde Staten, 94609
- Children's Hospital of Oakland
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Orange, California, Verenigde Staten, 92868
- Chao Family Comprehensive Cancer Center
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Orange, California, Verenigde Staten, 92868
- Children's Hospital of Orange County
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Palo Alto, California, Verenigde Staten, 94304
- Lucile Packard Children's Hospital at Stanford
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Sacramento, California, Verenigde Staten, 95816
- Sutter Cancer Center
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Sacramento, California, Verenigde Staten, 95817
- University of California Davis Medical Center
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San Diego, California, Verenigde Staten, 92120
- Kaiser Permanente-Southern California Permanente Medical Group
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San Diego, California, Verenigde Staten, 92123-4282
- Children's Hospital and Health Center
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San Francisco, California, Verenigde Staten, 94143-0128
- UCSF Cancer Center and Cancer Research Institute
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San Francisco, California, Verenigde Staten, 94115
- Kaiser Permanente Medical Group - San Francisco
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Santa Barbara, California, Verenigde Staten, 93102
- Santa Barbara Cottage Hospital
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Santa Clara, California, Verenigde Staten, 95051-5386
- Kaiser Permanente Medical Center - Santa Clara
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Travis Air Force Base, California, Verenigde Staten, 94535
- David Grant Medical Center
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Colorado
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Denver, Colorado, Verenigde Staten, 80218
- Childhood Hematology/Oncology Associates
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Denver, Colorado, Verenigde Staten, 80218
- Presbyterian-St Luke's Medical Center
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Denver, Colorado, Verenigde Staten, 80218
- Children's Hospital of Denver
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Connecticut
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Farmington, Connecticut, Verenigde Staten, 06360-7106
- University of Connecticut Health Center
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New Haven, Connecticut, Verenigde Staten, 06520-8028
- Yale Comprehensive Cancer Center
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Delaware
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Wilmington, Delaware, Verenigde Staten, 19899
- Alfred I. Dupont Institute
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District of Columbia
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Washington, District of Columbia, Verenigde Staten, 20307-5000
- Walter Reed Army Medical Center
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Washington, District of Columbia, Verenigde Staten, 20010-2970
- Children's National Medical Center
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Washington, District of Columbia, Verenigde Staten, 20007
- Lombardi Cancer Center
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Florida
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Fort Lauderdale, Florida, Verenigde Staten, 33316
- Broward General Medical Center
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Fort Myers, Florida, Verenigde Staten, 33908
- Children's Hospital of Southwest Florida
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Gainesville, Florida, Verenigde Staten, 32610-100277
- Shands Hospital and Clinics, University of Florida
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Hollywood, Florida, Verenigde Staten, 33021
- Joe DiMaggio Children's Hospital at Memorial
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Jacksonville, Florida, Verenigde Staten, 32207
- Nemours Children's Clinic
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Miami, Florida, Verenigde Staten, 33176-2197
- Baptist Hospital of Miami
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Miami, Florida, Verenigde Staten, 33155
- Miami Children's Hospital
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Miami, Florida, Verenigde Staten, 33136
- University of Miami-Jackson Memorial Hospital Medical Center
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Orlando, Florida, Verenigde Staten, 32803
- Walt Disney Memorial Cancer Institute
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Orlando, Florida, Verenigde Staten, 32806
- Nemours Children's Clinic-Orlando
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Pensacola, Florida, Verenigde Staten, 32504
- Sacred Heart Children's Hospital
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St. Petersburg, Florida, Verenigde Staten, 33701
- All Children's Hospital
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Tampa, Florida, Verenigde Staten, 33677-4227
- Tampa Children's Hospital
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West Palm Beach, Florida, Verenigde Staten, 33407
- St. Mary's Hospital
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Georgia
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Atlanta, Georgia, Verenigde Staten, 30322
- Emory University Hospital - Atlanta
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Atlanta, Georgia, Verenigde Staten, 30342
- Children's Healthcare of Atlanta - Scottish Rite
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Augusta, Georgia, Verenigde Staten, 30912-4000
- Medical College of Georgia Comprehensive Cancer Center
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Macon, Georgia, Verenigde Staten, 31201
- Medical Center of Central Georgia
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Savannah, Georgia, Verenigde Staten, 31403-3089
- Memorial Health University Medical Center, Inc.
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Hawaii
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Honolulu, Hawaii, Verenigde Staten, 96859-5000
- Tripler Army Medical Center
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Honolulu, Hawaii, Verenigde Staten, 96813
- Cancer Research Center of Hawaii
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Idaho
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Boise, Idaho, Verenigde Staten, 83712
- Mountain States Tumor Institute
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Illinois
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Chicago, Illinois, Verenigde Staten, 60612
- University of Illinois at Chicago
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Chicago, Illinois, Verenigde Staten, 60637-1470
- University of Chicago Cancer Research Center
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Chicago, Illinois, Verenigde Staten, 60612
- Rush-Presbyterian-St. Luke's Medical Center
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Chicago, Illinois, Verenigde Staten, 60614
- Children's Memorial Hospital, Chicago
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Oak Lawn, Illinois, Verenigde Staten, 60453
- Hope Children's Hospital
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Park Ridge, Illinois, Verenigde Staten, 60068
- Lutheran General Hospital
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Peoria, Illinois, Verenigde Staten, 61637
- Saint Jude Midwest Affiliate
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Rockford, Illinois, Verenigde Staten, 61104
- University Child Health Services Clinic
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Springfield, Illinois, Verenigde Staten, 62794-9230
- Southern Illinois University School of Medicine
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Indiana
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Indianapolis, Indiana, Verenigde Staten, 46202-5289
- Indiana University Cancer Center
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Indianapolis, Indiana, Verenigde Staten, 46260
- St. Vincent Hospital and Health Care Center
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Iowa
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Des Moines, Iowa, Verenigde Staten, 50308
- Raymond Blank Memorial Hospital for Children
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Des Moines, Iowa, Verenigde Staten, 50309
- John Stoddard Cancer Center
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Iowa City, Iowa, Verenigde Staten, 52242-1009
- Holden Comprehensive Cancer Center at the University of Iowa
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Kansas
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Wichita, Kansas, Verenigde Staten, 67214
- Wesley Medical Center
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Kentucky
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Lexington, Kentucky, Verenigde Staten, 40536-0084
- Albert B. Chandler Medical Center, University of Kentucky
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Louisville, Kentucky, Verenigde Staten, 40232
- Kosair Children's Hospital
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Louisiana
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New Orleans, Louisiana, Verenigde Staten, 70112
- Tulane University School of Medicine
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New Orleans, Louisiana, Verenigde Staten, 70118
- Children's Hospital of New Orleans
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New Orleans, Louisiana, Verenigde Staten, 70121
- Ochsner Clinic
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Maine
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Bangor, Maine, Verenigde Staten, 04401
- Eastern Maine Medical Center
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Scarborough, Maine, Verenigde Staten, 04074
- Maine Children's Cancer Program
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Maryland
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Baltimore, Maryland, Verenigde Staten, 21231-2410
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
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Baltimore, Maryland, Verenigde Staten, 21201
- Marlene & Stewart Greenebaum Cancer Center, University of Maryland
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Baltimore, Maryland, Verenigde Staten, 21225
- Sinai Hospital of Baltimore
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Massachusetts
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Boston, Massachusetts, Verenigde Staten, 02115
- Dana-Farber Cancer Institute
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Boston, Massachusetts, Verenigde Staten, 02111
- Boston Floating Hospital Infants and Children
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Springfield, Massachusetts, Verenigde Staten, 01199
- Baystate Medical Center
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Worcester, Massachusetts, Verenigde Staten, 01655
- University of Massachusetts Memorial Medical Center
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Michigan
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Ann Arbor, Michigan, Verenigde Staten, 48109
- Mott Children's Hospital
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Detroit, Michigan, Verenigde Staten, 48202
- Henry Ford Hospital
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Detroit, Michigan, Verenigde Staten, 48201
- Children's Hospital of Michigan
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Detroit, Michigan, Verenigde Staten, 48236
- St. John Hospital and Medical Center
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East Lansing, Michigan, Verenigde Staten, 48824
- Michigan State University
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Flint, Michigan, Verenigde Staten, 48503
- Hurley Medical Center
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Grand Rapids, Michigan, Verenigde Staten, 49503
- Spectrum Health and DeVos Children's Hospital
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Kalamazoo, Michigan, Verenigde Staten, 49007
- Bronson Methodist Hospital
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Royal Oak, Michigan, Verenigde Staten, 48073
- William Beaumont Hospital
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Minnesota
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Duluth, Minnesota, Verenigde Staten, 55805
- Duluth Clinic
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Minneapolis, Minnesota, Verenigde Staten, 55404
- Children's Hospitals and Clinics - Minneapolis
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Rochester, Minnesota, Verenigde Staten, 55905
- Mayo Clinic Cancer Center
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Saint Paul, Minnesota, Verenigde Staten, 55102
- Children'S Hospitals and Clinics of Minnesota
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Mississippi
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Jackson, Mississippi, Verenigde Staten, 39216-4505
- University of Mississippi Medical Center
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Missouri
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Kansas City, Missouri, Verenigde Staten, 64108
- Children's Mercy Hospital
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Saint Louis, Missouri, Verenigde Staten, 63110
- St. Louis Children's Hospital
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Saint Louis, Missouri, Verenigde Staten, 63104
- Cardinal Glennon Children's Hospital
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Nebraska
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Omaha, Nebraska, Verenigde Staten, 68198-3330
- University of Nebraska Medical Center
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Omaha, Nebraska, Verenigde Staten, 68114
- Children's Hospital of Omaha
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Nevada
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Las Vegas, Nevada, Verenigde Staten, 89109-2306
- Sunrise Hospital and Medical Center
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New Hampshire
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Lebanon, New Hampshire, Verenigde Staten, 03756-0002
- Norris Cotton Cancer Center
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New Jersey
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Hackensack, New Jersey, Verenigde Staten, 07601
- Hackensack University Medical Center
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New Brunswick, New Jersey, Verenigde Staten, 08901
- Cancer Institute Of New Jersey
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Newark, New Jersey, Verenigde Staten, 07112
- Newark Beth Israel Medical Center
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Paterson, New Jersey, Verenigde Staten, 07503
- St. Joseph's Hospital and Medical Center
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Summit, New Jersey, Verenigde Staten, 07901
- Atlantic Health System
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New Mexico
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Albuquerque, New Mexico, Verenigde Staten, 87131
- University of New Mexico School of Medicine
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New York
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Albany, New York, Verenigde Staten, 12208
- Cancer Center of Albany Medical Center
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Bronx, New York, Verenigde Staten, 10467-2490
- Montefiore Medical Center
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Brooklyn, New York, Verenigde Staten, 11219
- Maimonides Medical Center
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Brooklyn, New York, Verenigde Staten, 11201
- Brooklyn Hospital Center
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Brooklyn, New York, Verenigde Staten, 11203
- State University of New York Health Science Center at Brooklyn College of Medicine
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Brooklyn, New York, Verenigde Staten, 11212
- Brookdale University Hospital and Medical Center
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Buffalo, New York, Verenigde Staten, 14263-0001
- Roswell Park Cancer Institute
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Manhasset, New York, Verenigde Staten, 11030
- North Shore University Hospital
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New Hyde Park, New York, Verenigde Staten, 11042
- Schneider Children's Hospital
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New York, New York, Verenigde Staten, 10021
- Memorial Sloan-Kettering Cancer Center
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New York, New York, Verenigde Staten, 10021
- New York Presbyterian Hospital - Cornell Campus
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New York, New York, Verenigde Staten, 10029
- Mount Sinai School of Medicine
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New York, New York, Verenigde Staten, 10032
- Columbia Presbyterian Hospital
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Rochester, New York, Verenigde Staten, 14642
- University of Rochester Cancer Center
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Stony Brook, New York, Verenigde Staten, 11790-7775
- State University of New York Health Sciences Center - Stony Brook
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Syracuse, New York, Verenigde Staten, 13210
- State University of New York - Upstate Medical University
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Valhalla, New York, Verenigde Staten, 10595
- New York Medical College
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North Carolina
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Asheville, North Carolina, Verenigde Staten, 28801
- Mission Saint Joseph's Health System
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Chapel Hill, North Carolina, Verenigde Staten, 27599-7295
- Lineberger Comprehensive Cancer Center, UNC
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Charlotte, North Carolina, Verenigde Staten, 28232-2861
- Carolinas Medical Center
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Charlotte, North Carolina, Verenigde Staten, 28233-3549
- Presbyterian Healthcare
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Durham, North Carolina, Verenigde Staten, 27710
- Duke Comprehensive Cancer Center
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Greenville, North Carolina, Verenigde Staten, 27858-4354
- East Carolina University School of Medicine
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North Dakota
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Fargo, North Dakota, Verenigde Staten, 58108-6001
- Dakota Cancer Institute
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Ohio
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Akron, Ohio, Verenigde Staten, 44308
- Children's Hospital Medical Center of Akron
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Cincinnati, Ohio, Verenigde Staten, 45229-3039
- Children's Hospital Medical Center - Cincinnati
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Cleveland, Ohio, Verenigde Staten, 44195
- Cleveland Clinic Taussig Cancer Center
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Cleveland, Ohio, Verenigde Staten, 44106-5065
- Ireland Cancer Center
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Columbus, Ohio, Verenigde Staten, 43205-2696
- Children's Hospital of Columbus
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Dayton, Ohio, Verenigde Staten, 45404
- Children's Medical Center - Dayton
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Toledo, Ohio, Verenigde Staten, 43601
- Toledo Children's Hospital
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Toledo, Ohio, Verenigde Staten, 43608
- St. Vincent Mercy Medical Center
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Youngstown, Ohio, Verenigde Staten, 44501
- Forum Health-Tod Childrens Hospital
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Oklahoma
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Oklahoma City, Oklahoma, Verenigde Staten, 73104
- Children's Hospital of Oklahoma
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Tulsa, Oklahoma, Verenigde Staten, 74136
- Natalie Warren Bryant Cancer Center
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Oregon
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Portland, Oregon, Verenigde Staten, 97201-3098
- Doernbecher Children's Hospital
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Portland, Oregon, Verenigde Staten, 97227
- Legacy Emanuel Hospital and Health Center
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Pennsylvania
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Danville, Pennsylvania, Verenigde Staten, 17822-2001
- Geisinger Medical Center
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Hershey, Pennsylvania, Verenigde Staten, 17033-0850
- Milton S. Hershey Medical Center
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Philadelphia, Pennsylvania, Verenigde Staten, 19104
- Children's Hospital of Philadelphia
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Philadelphia, Pennsylvania, Verenigde Staten, 19134-1095
- St. Christopher's Hospital for Children
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Pittsburgh, Pennsylvania, Verenigde Staten, 15213
- Children's Hospital of Pittsburgh
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Rhode Island
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Providence, Rhode Island, Verenigde Staten, 02903
- Rhode Island Hospital
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South Carolina
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Charleston, South Carolina, Verenigde Staten, 29425-0721
- Medical University of South Carolina
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Columbia, South Carolina, Verenigde Staten, 29203
- Center for Cancer Treatment and Research
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Greenville, South Carolina, Verenigde Staten, 29605
- Children's Hospital of Greenville Hospital System
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South Dakota
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Sioux Falls, South Dakota, Verenigde Staten, 57105
- Avera Cancer Institute
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Sioux Falls, South Dakota, Verenigde Staten, 57117
- Sioux Valley Hospital
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Tennessee
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Johnson City, Tennessee, Verenigde Staten, 37614-0622
- James H. Quillen College of Medicine
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Knoxville, Tennessee, Verenigde Staten, 37901
- East Tennessee Children's Hospital
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Memphis, Tennessee, Verenigde Staten, 38105-2794
- Saint Jude Children's Research Hospital
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Nashville, Tennessee, Verenigde Staten, 37232-6838
- Vanderbilt-Ingram Cancer Center
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Texas
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Amarillo, Texas, Verenigde Staten, 79106
- Texas Tech University Health Sciences Center School of Medicine
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Austin, Texas, Verenigde Staten, 78701
- Children's Hospital of Austin
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Dallas, Texas, Verenigde Staten, 75230
- Medical City Dallas Hospital
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Dallas, Texas, Verenigde Staten, 75235-9154
- Simmons Cancer Center - Dallas
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Fort Worth, Texas, Verenigde Staten, 76104
- Cook Children's Medical Center - Fort Worth
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Galveston, Texas, Verenigde Staten, 77555-0209
- University of Texas Medical Branch
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Houston, Texas, Verenigde Staten, 77030
- Baylor College of Medicine
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Houston, Texas, Verenigde Staten, 77030-4009
- University of Texas - MD Anderson Cancer Center
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Lackland Air Force Base, Texas, Verenigde Staten, 78236-5300
- San Antonio Military Pediatric Cancer and Blood Disorders Center
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Lubbock, Texas, Verenigde Staten, 79410
- Covenant Children's Hospital
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San Antonio, Texas, Verenigde Staten, 78284-7811
- University of Texas Health Science Center at San Antonio
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San Antonio, Texas, Verenigde Staten, 78229
- Methodist Health Care System
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Temple, Texas, Verenigde Staten, 76508
- Scott and White Memorial Hospital
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Vermont
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Burlington, Vermont, Verenigde Staten, 05401-3498
- Vermont Cancer Center
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Virginia
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Charlottesville, Virginia, Verenigde Staten, 22908
- Cancer Center at the University of Virginia
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Falls Church, Virginia, Verenigde Staten, 22042-3300
- Inova Fairfax Hospital
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Norfolk, Virginia, Verenigde Staten, 23507
- Children's Hospital of The King's Daughters
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Portsmouth, Virginia, Verenigde Staten, 23708-2197
- Naval Medical Center, Portsmouth
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Richmond, Virginia, Verenigde Staten, 23298-0037
- Massey Cancer Center
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Roanoke, Virginia, Verenigde Staten, 24013
- Carilion Roanoke Community Hospital
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Washington
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Seattle, Washington, Verenigde Staten, 98105
- Children's Hospital and Regional Medical Center - Seattle
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Seattle, Washington, Verenigde Staten, 98109-1024
- Fred Hutchinson Cancer Research Center
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Seattle, Washington, Verenigde Staten, 98112
- Group Health Cooperative of Puget Sound
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Spokane, Washington, Verenigde Staten, 99210-0248
- Deaconess Medical Center
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Tacoma, Washington, Verenigde Staten, 98431-5000
- Madigan Army Medical Center
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Tacoma, Washington, Verenigde Staten, 98405
- Mary Bridge Children's Health Center
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West Virginia
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Charleston, West Virginia, Verenigde Staten, 25302
- West Virginia University - Charleston
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Huntington, West Virginia, Verenigde Staten, 25701
- Cabell-Huntington Hospital, Inc
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Morgantown, West Virginia, Verenigde Staten, 26506-9300
- West Virginia University Hospitals
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Wisconsin
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Green Bay, Wisconsin, Verenigde Staten, 54307-3508
- St. Vincent Hospital
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Green Bay, Wisconsin, Verenigde Staten, 54301
- Bellin Memorial Hospital
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La Crosse, Wisconsin, Verenigde Staten, 54601
- Gundersen Lutheran Medical Center
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Madison, Wisconsin, Verenigde Staten, 53792-0001
- University of Wisconsin Hospital and Clinics
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Milwaukee, Wisconsin, Verenigde Staten, 53226
- Midwest Children's Cancer Center
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Bern, Zwitserland, CH 3010
- Swiss Pediatric Oncology Group Bern
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Geneva, Zwitserland, CH 1211
- Swiss Pediatric Oncology Group Geneva
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Lausanne, Zwitserland, CH 1011
- Swiss Pediatric Oncology Group Lausanne
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Deelname Criteria
Onderzoekers zoeken naar mensen die aan een bepaalde beschrijving voldoen, de zogenaamde geschiktheidscriteria. Enkele voorbeelden van deze criteria zijn iemands algemene gezondheidstoestand of eerdere behandelingen.
Geschiktheidscriteria
Leeftijden die in aanmerking komen voor studie
Niet ouder dan 21 jaar (Kind, Volwassen)
Accepteert gezonde vrijwilligers
Nee
Geslachten die in aanmerking komen voor studie
Allemaal
Beschrijving
DISEASE CHARACTERISTICS: Histologically confirmed recurrent or refractory solid malignant tumors of childhood including: Soft tissue sarcoma Rhabdomyosarcoma Nonrhabdomyosarcoma Extraosseous Ewing's sarcoma CNS tumors Astrocytoma Primitive neuroectodermal tumor Atypical teratoid/rhabdoid tumors Ependymoma Recurrent neuroblastoma Measurable disease No more than 2 prior treatment regimens
PATIENT CHARACTERISTICS: Age: 21 and under at diagnosis Performance status: ECOG 0-2 Life expectancy: At least 2 months Hematopoietic: For patients with solid tumors (unless marrow involvement): Absolute neutrophil count (ANC) at least 1000/mm3 Platelet count at least 100,000/mm3 (transfusion independent) Hemoglobin at least 10 g/dL (RBC transfusions allowed) For patients post bone marrow transplantation: ANC at least 1,000/mm3 Platelet count at least 50,000/mm3 (transfusion independent) Hemoglobin at least 10 g/dL (RBC transfusions allowed) Hepatic: Total bilirubin no greater than 1.5 times normal SGOT/SGPT less than 2.5 times normal Renal: Creatinine no greater than 1.5 times normal OR Creatinine clearance or radioisotope glomerular filtration rate at least 70 mL/min Neurologic: Seizure disorder allowed if well controlled CNS toxicity no greater than grade 2
PRIOR CONCURRENT THERAPY: Biologic therapy: At least 6 months since prior bone marrow transplantation No concurrent immunomodulating agents Chemotherapy: At least 2 weeks since prior chemotherapy (4 weeks for nitrosourea) and recovered No other concurrent chemotherapy Endocrine therapy: No concurrent corticosteroids except for increased intracranial pressure due to CNS tumors Radiotherapy: At least 6 months since prior radiotherapy to craniospinal axis, spine, and/or more than 50% of the bony pelvis Concurrent radiotherapy to localized painful lesions allowed if at least one measurable lesion is not in radiation field Surgery: Not specified Other: No concurrent participation in another CCG, POG, or COG therapeutic study
Studie plan
Dit gedeelte bevat details van het studieplan, inclusief hoe de studie is opgezet en wat de studie meet.
Hoe is de studie opgezet?
Ontwerpdetails
- Primair doel: Behandeling
Wapens en interventies
Deelnemersgroep / Arm |
Interventie / Behandeling |
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Experimenteel: Stratum 1 - Soft Tissue Sarcoma
See detailed description.
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Andere namen:
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Experimenteel: Stratum 2 - CNS Tumors
See detailed description.
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Andere namen:
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Experimenteel: Stratum 3 - Neuroblastoma
See detailed description.
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Andere namen:
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Wat meet het onderzoek?
Primaire uitkomstmaten
Uitkomstmaat |
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Ziekteprogressie
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Medewerkers en onderzoekers
Hier vindt u mensen en organisaties die betrokken zijn bij dit onderzoek.
Sponsor
Medewerkers
Onderzoekers
- Studie stoel: John F. Kuttesch, PhD, MD, M.D. Anderson Cancer Center
Publicaties en nuttige links
De persoon die verantwoordelijk is voor het invoeren van informatie over het onderzoek stelt deze publicaties vrijwillig ter beschikking. Dit kan gaan over alles wat met het onderzoek te maken heeft.
Studie record data
Deze datums volgen de voortgang van het onderzoeksdossier en de samenvatting van de ingediende resultaten bij ClinicalTrials.gov. Studieverslagen en gerapporteerde resultaten worden beoordeeld door de National Library of Medicine (NLM) om er zeker van te zijn dat ze voldoen aan specifieke kwaliteitscontrolenormen voordat ze op de openbare website worden geplaatst.
Bestudeer belangrijke data
Studie start
1 mei 1998
Primaire voltooiing (Werkelijk)
1 maart 2006
Studie voltooiing (Werkelijk)
1 maart 2007
Studieregistratiedata
Eerst ingediend
1 november 1999
Eerst ingediend dat voldeed aan de QC-criteria
27 oktober 2003
Eerst geplaatst (Schatting)
28 oktober 2003
Updates van studierecords
Laatste update geplaatst (Schatting)
28 juli 2014
Laatste update ingediend die voldeed aan QC-criteria
25 juli 2014
Laatst geverifieerd
1 juli 2014
Meer informatie
Termen gerelateerd aan deze studie
Trefwoorden
- recidiverende kinderrabdomyosarcoom
- recidiverend neuroblastoom
- recidiverend Ewing-sarcoom / perifere primitieve neuro-ectodermale tumor
- terugkerende kinder supratentoriale primitieve neuroectodermale tumor
- recidiverend cerebellair astrocytoom bij kinderen
- recidiverend cerebraal astrocytoom bij kinderen
- recidiverend ependymoom bij kinderen
- recidiverend wekedelensarcoom bij kinderen
Aanvullende relevante MeSH-voorwaarden
- Ziekten van het zenuwstelsel
- Neoplasmata, bindweefsel en zacht weefsel
- Neoplasmata per histologisch type
- Neoplasmata
- Neoplasmata per site
- Neoplasmata, glandulair en epitheel
- Neoplasmata, neuro-epitheliaal
- Neuro-ectodermale tumoren
- Neoplasmata, kiemcellen en embryonaal
- Neoplasmata, zenuwweefsel
- Neuro-ectodermale tumoren, primitief
- Neuro-ectodermale tumoren, primitief, perifeer
- Sarcoom
- Neoplasmata van het zenuwstelsel
- Neoplasmata van het centrale zenuwstelsel
- Neuroblastoom
- Moleculaire mechanismen van farmacologische werking
- Antineoplastische middelen
- Tubuline-modulatoren
- Antimitotische middelen
- Mitose modulatoren
- Antineoplastische middelen, fytogeen
- Vinorelbine
Andere studie-ID-nummers
- A09705
- COG-A09705 (Andere identificatie: Children's Oncology Group)
- CCG-09705 (Andere identificatie: Children's Cancer Group)
- CDR0000066106 (Andere identificatie: Clinical Trials.gov)
Deze informatie is zonder wijzigingen rechtstreeks van de website clinicaltrials.gov gehaald. Als u verzoeken heeft om uw onderzoeksgegevens te wijzigen, te verwijderen of bij te werken, neem dan contact op met register@clinicaltrials.gov. Zodra er een wijziging wordt doorgevoerd op clinicaltrials.gov, wordt deze ook automatisch bijgewerkt op onze website .
Klinische onderzoeken op Sarcoom
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Memorial Sloan Kettering Cancer CenterM.D. Anderson Cancer Center; Stanford University; Rockefeller UniversityActief, niet wervend
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PfizerVoltooidNSCLC | SCCHN | Deel 1 | MELANOMA | OVCA | SARCOMA | ANDERE VASTE TUMOREN | Deel 1 en 2 | UROTHELIAAL CARCINOOMVerenigde Staten, Korea, republiek van, Russische Federatie, Polen, Maleisië, Bulgarije, Oekraïne
Klinische onderzoeken op vinorelbine tartraat
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National Cancer Institute, SlovakiaIngetrokkenUitgezaaide borstkankerSlowakije