Vinorelbine in Treating Children With Recurrent or Refractory Cancers
25 juillet 2014 mis à jour par: Children's Oncology Group
A Phase II Study of Navelbine (Vinorelbine) In Children With Recurrent Or Refractory Malignancies
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of vinorelbine in treating children with recurrent or refractory cancer.
Aperçu de l'étude
Statut
Complété
Les conditions
Intervention / Traitement
Description détaillée
OBJECTIVES: I. Determine the response rate of children with recurrent or refractory malignancies treated with vinorelbine. II. Assess the toxic effects of this drug in these children.
OUTLINE: Patients receive vinorelbine IV over 6-10 minutes weekly on weeks 1-6. Treatment repeats every 8 weeks for a total of 10 courses in the absence of disease progression or unacceptable toxicity. Patients are followed every 4 months for 2 years, every 6 months for 1 year, and then annually thereafter.
PROJECTED ACCRUAL: A maximum of 100 patients will be accrued for this study within 2 years.
Type d'étude
Interventionnel
Inscription (Réel)
50
Phase
- Phase 2
Contacts et emplacements
Cette section fournit les coordonnées de ceux qui mènent l'étude et des informations sur le lieu où cette étude est menée.
Lieux d'étude
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New South Wales
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Randwick, New South Wales, Australie, 2031
- Sydney Children's Hospital
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Westmead, New South Wales, Australie, 2145
- Children's Hospital at Westmead
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Queensland
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Brisbane, Queensland, Australie, 4029
- Royal Children's Hospital
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Victoria
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Parkville, Victoria, Australie, 3052
- Royal Children's Hospital
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Western Australia
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Perth, Western Australia, Australie, 6001
- Princess Margaret Hospital for Children
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Alberta
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Calgary, Alberta, Canada, T2T 5C7
- Alberta Children's Hospital
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Edmonton, Alberta, Canada, T6G 1Z2
- Cross Cancer Institute
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British Columbia
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Vancouver, British Columbia, Canada, V6H 3V4
- British Columbia Children's Hospital
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Manitoba
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Winnipeg, Manitoba, Canada, R3E 0V9
- CancerCare Manitoba
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Newfoundland and Labrador
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St. John's, Newfoundland and Labrador, Canada, A1A 1R8
- Janeway Children's Health and Rehabilitation Centre
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Nova Scotia
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Halifax, Nova Scotia, Canada, B3J 3G9
- IWK Health Centre
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Ontario
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Hamilton, Ontario, Canada, L8N 3Z5
- Children's Hospital
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London, Ontario, Canada, N6C 2V5
- Children's Hospital of Western Ontario
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Ottawa, Ontario, Canada, K1H 8L1
- Children's Hospital of Eastern Ontario
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Toronto, Ontario, Canada, M5G 1X8
- Hospital for Sick Children
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Quebec
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Montreal, Quebec, Canada, H3T 1C5
- Hopital Sainte Justine
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Montreal, Quebec, Canada, H3H 1P3
- McGill University Health Center - Montreal Children's Hospital
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Sainte Foy, Quebec, Canada, GIV 4G2
- Centre Hospitalier de l'Universite Laval
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Sainte-Foy, Quebec, Canada, G1V 4G2
- Laval University Medical Center
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Saskatchewan
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Regina, Saskatchewan, Canada, S4T 7T1
- Allan Blair Cancer Centre
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Saskatoon, Saskatchewan, Canada, S7N 4H4
- Saskatoon Cancer Centre
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Auckland, Nouvelle-Zélande
- Starship Children's Hospital
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Groningen, Pays-Bas, 9713 EZ
- Academisch Ziekenhuis Groningen
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San Juan, Porto Rico, 00936-5067
- University of Puerto Rico School of Medicine Medical Sciences Campus
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Santurce, Porto Rico, 00912
- San Jorge Childrens Hospital
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Bern, Suisse, CH 3010
- Swiss Pediatric Oncology Group Bern
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Geneva, Suisse, CH 1211
- Swiss Pediatric Oncology Group Geneva
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Lausanne, Suisse, CH 1011
- Swiss Pediatric Oncology Group Lausanne
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Alabama
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Birmingham, Alabama, États-Unis, 35294-3300
- University of Alabama at Birmingham Comprehensive Cancer Center
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Mobile, Alabama, États-Unis, 36617-2293
- University of South Alabama Medical Center
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Arizona
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Phoenix, Arizona, États-Unis, 85006
- Phoenix Children's Hospital
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Tucson, Arizona, États-Unis, 85724
- Arizona Cancer Center
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Arkansas
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Little Rock, Arkansas, États-Unis, 72205
- University of Arkansas for Medical Sciences
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California
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Downey, California, États-Unis, 90242
- Southern California Permanente Medical Group
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Duarte, California, États-Unis, 91010-3000
- Cancer Center and Beckman Research Institute, City of Hope
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La Jolla, California, États-Unis, 92093-0658
- University of California San Diego Cancer Center
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Loma Linda, California, États-Unis, 92354
- Loma Linda University Medical Center
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Long Beach, California, États-Unis, 90801-1428
- Jonathan Jaques Children'S Cancer Center
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Los Angeles, California, États-Unis, 90048
- Cedars-Sinai Medical Center
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Los Angeles, California, États-Unis, 90095-1781
- Jonsson Comprehensive Cancer Center, UCLA
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Los Angeles, California, États-Unis, 90027-0700
- Children's Hospital Los Angeles
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Madera, California, États-Unis, 93638
- Valley Children's Hospital
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Oakland, California, États-Unis, 94609
- Children's Hospital of Oakland
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Orange, California, États-Unis, 92868
- Chao Family Comprehensive Cancer Center
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Orange, California, États-Unis, 92868
- Children's Hospital of Orange County
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Palo Alto, California, États-Unis, 94304
- Lucile Packard Children's Hospital at Stanford
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Sacramento, California, États-Unis, 95816
- Sutter Cancer Center
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Sacramento, California, États-Unis, 95817
- University of California Davis Medical Center
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San Diego, California, États-Unis, 92120
- Kaiser Permanente-Southern California Permanente Medical Group
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San Diego, California, États-Unis, 92123-4282
- Children's Hospital and Health Center
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San Francisco, California, États-Unis, 94143-0128
- UCSF Cancer Center and Cancer Research Institute
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San Francisco, California, États-Unis, 94115
- Kaiser Permanente Medical Group - San Francisco
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Santa Barbara, California, États-Unis, 93102
- Santa Barbara Cottage Hospital
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Santa Clara, California, États-Unis, 95051-5386
- Kaiser Permanente Medical Center - Santa Clara
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Travis Air Force Base, California, États-Unis, 94535
- David Grant Medical Center
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Colorado
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Denver, Colorado, États-Unis, 80218
- Childhood Hematology/Oncology Associates
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Denver, Colorado, États-Unis, 80218
- Presbyterian-St Luke's Medical Center
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Denver, Colorado, États-Unis, 80218
- Children's Hospital of Denver
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Connecticut
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Farmington, Connecticut, États-Unis, 06360-7106
- University of Connecticut Health Center
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New Haven, Connecticut, États-Unis, 06520-8028
- Yale Comprehensive Cancer Center
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Delaware
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Wilmington, Delaware, États-Unis, 19899
- Alfred I. Dupont Institute
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District of Columbia
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Washington, District of Columbia, États-Unis, 20307-5000
- Walter Reed Army Medical Center
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Washington, District of Columbia, États-Unis, 20010-2970
- Children's National Medical Center
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Washington, District of Columbia, États-Unis, 20007
- Lombardi Cancer Center
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Florida
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Fort Lauderdale, Florida, États-Unis, 33316
- Broward General Medical Center
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Fort Myers, Florida, États-Unis, 33908
- Children's Hospital of Southwest Florida
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Gainesville, Florida, États-Unis, 32610-100277
- Shands Hospital and Clinics, University of Florida
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Hollywood, Florida, États-Unis, 33021
- Joe DiMaggio Children's Hospital at Memorial
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Jacksonville, Florida, États-Unis, 32207
- Nemours Children's Clinic
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Miami, Florida, États-Unis, 33176-2197
- Baptist Hospital of Miami
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Miami, Florida, États-Unis, 33155
- Miami Children's Hospital
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Miami, Florida, États-Unis, 33136
- University of Miami-Jackson Memorial Hospital Medical Center
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Orlando, Florida, États-Unis, 32803
- Walt Disney Memorial Cancer Institute
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Orlando, Florida, États-Unis, 32806
- Nemours Children's Clinic-Orlando
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Pensacola, Florida, États-Unis, 32504
- Sacred Heart Children's Hospital
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St. Petersburg, Florida, États-Unis, 33701
- All Children's Hospital
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Tampa, Florida, États-Unis, 33677-4227
- Tampa Children's Hospital
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West Palm Beach, Florida, États-Unis, 33407
- St. Mary's Hospital
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Georgia
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Atlanta, Georgia, États-Unis, 30322
- Emory University Hospital - Atlanta
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Atlanta, Georgia, États-Unis, 30342
- Children's Healthcare of Atlanta - Scottish Rite
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Augusta, Georgia, États-Unis, 30912-4000
- Medical College of Georgia Comprehensive Cancer Center
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Macon, Georgia, États-Unis, 31201
- Medical Center of Central Georgia
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Savannah, Georgia, États-Unis, 31403-3089
- Memorial Health University Medical Center, Inc.
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Hawaii
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Honolulu, Hawaii, États-Unis, 96859-5000
- Tripler Army Medical Center
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Honolulu, Hawaii, États-Unis, 96813
- Cancer Research Center of Hawaii
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Idaho
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Boise, Idaho, États-Unis, 83712
- Mountain States Tumor Institute
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Illinois
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Chicago, Illinois, États-Unis, 60612
- University of Illinois at Chicago
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Chicago, Illinois, États-Unis, 60637-1470
- University of Chicago Cancer Research Center
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Chicago, Illinois, États-Unis, 60612
- Rush-Presbyterian-St. Luke's Medical Center
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Chicago, Illinois, États-Unis, 60614
- Children's Memorial Hospital, Chicago
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Oak Lawn, Illinois, États-Unis, 60453
- Hope Children's Hospital
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Park Ridge, Illinois, États-Unis, 60068
- Lutheran General Hospital
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Peoria, Illinois, États-Unis, 61637
- Saint Jude Midwest Affiliate
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Rockford, Illinois, États-Unis, 61104
- University Child Health Services Clinic
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Springfield, Illinois, États-Unis, 62794-9230
- Southern Illinois University School of Medicine
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Indiana
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Indianapolis, Indiana, États-Unis, 46202-5289
- Indiana University Cancer Center
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Indianapolis, Indiana, États-Unis, 46260
- St. Vincent Hospital and Health Care Center
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Iowa
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Des Moines, Iowa, États-Unis, 50308
- Raymond Blank Memorial Hospital for Children
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Des Moines, Iowa, États-Unis, 50309
- John Stoddard Cancer Center
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Iowa City, Iowa, États-Unis, 52242-1009
- Holden Comprehensive Cancer Center at the University of Iowa
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Kansas
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Wichita, Kansas, États-Unis, 67214
- Wesley Medical Center
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Kentucky
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Lexington, Kentucky, États-Unis, 40536-0084
- Albert B. Chandler Medical Center, University of Kentucky
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Louisville, Kentucky, États-Unis, 40232
- Kosair Children's Hospital
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Louisiana
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New Orleans, Louisiana, États-Unis, 70112
- Tulane University School of Medicine
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New Orleans, Louisiana, États-Unis, 70118
- Children's Hospital of New Orleans
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New Orleans, Louisiana, États-Unis, 70121
- Ochsner Clinic
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Maine
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Bangor, Maine, États-Unis, 04401
- Eastern Maine Medical Center
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Scarborough, Maine, États-Unis, 04074
- Maine Children's Cancer Program
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Maryland
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Baltimore, Maryland, États-Unis, 21231-2410
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
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Baltimore, Maryland, États-Unis, 21201
- Marlene & Stewart Greenebaum Cancer Center, University of Maryland
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Baltimore, Maryland, États-Unis, 21225
- Sinai Hospital of Baltimore
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Massachusetts
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Boston, Massachusetts, États-Unis, 02115
- Dana-Farber Cancer Institute
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Boston, Massachusetts, États-Unis, 02111
- Boston Floating Hospital Infants and Children
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Springfield, Massachusetts, États-Unis, 01199
- Baystate Medical Center
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Worcester, Massachusetts, États-Unis, 01655
- University of Massachusetts Memorial Medical Center
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Michigan
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Ann Arbor, Michigan, États-Unis, 48109
- Mott Children's Hospital
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Detroit, Michigan, États-Unis, 48202
- Henry Ford Hospital
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Detroit, Michigan, États-Unis, 48201
- Children's Hospital of Michigan
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Detroit, Michigan, États-Unis, 48236
- St. John Hospital and Medical Center
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East Lansing, Michigan, États-Unis, 48824
- Michigan State University
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Flint, Michigan, États-Unis, 48503
- Hurley Medical Center
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Grand Rapids, Michigan, États-Unis, 49503
- Spectrum Health and DeVos Children's Hospital
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Kalamazoo, Michigan, États-Unis, 49007
- Bronson Methodist Hospital
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Royal Oak, Michigan, États-Unis, 48073
- William Beaumont Hospital
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Minnesota
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Duluth, Minnesota, États-Unis, 55805
- Duluth Clinic
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Minneapolis, Minnesota, États-Unis, 55404
- Children's Hospitals and Clinics - Minneapolis
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Rochester, Minnesota, États-Unis, 55905
- Mayo Clinic Cancer Center
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Saint Paul, Minnesota, États-Unis, 55102
- Children's Hospitals and Clinics of Minnesota
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Mississippi
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Jackson, Mississippi, États-Unis, 39216-4505
- University Of Mississippi Medical Center
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Missouri
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Kansas City, Missouri, États-Unis, 64108
- Children's Mercy Hospital
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Saint Louis, Missouri, États-Unis, 63110
- St. Louis Children's Hospital
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Saint Louis, Missouri, États-Unis, 63104
- Cardinal Glennon Children's Hospital
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Nebraska
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Omaha, Nebraska, États-Unis, 68198-3330
- University of Nebraska Medical Center
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Omaha, Nebraska, États-Unis, 68114
- Children's Hospital of Omaha
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Nevada
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Las Vegas, Nevada, États-Unis, 89109-2306
- Sunrise Hospital and Medical Center
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New Hampshire
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Lebanon, New Hampshire, États-Unis, 03756-0002
- Norris Cotton Cancer Center
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New Jersey
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Hackensack, New Jersey, États-Unis, 07601
- Hackensack University Medical Center
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New Brunswick, New Jersey, États-Unis, 08901
- Cancer Institute of New Jersey
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Newark, New Jersey, États-Unis, 07112
- Newark Beth Israel Medical Center
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Paterson, New Jersey, États-Unis, 07503
- St. Joseph's Hospital and Medical Center
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Summit, New Jersey, États-Unis, 07901
- Atlantic Health System
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New Mexico
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Albuquerque, New Mexico, États-Unis, 87131
- University of New Mexico School of Medicine
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New York
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Albany, New York, États-Unis, 12208
- Cancer Center of Albany Medical Center
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Bronx, New York, États-Unis, 10467-2490
- Montefiore Medical Center
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Brooklyn, New York, États-Unis, 11219
- Maimonides Medical Center
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Brooklyn, New York, États-Unis, 11201
- Brooklyn Hospital Center
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Brooklyn, New York, États-Unis, 11203
- State University of New York Health Science Center at Brooklyn College of Medicine
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Brooklyn, New York, États-Unis, 11212
- Brookdale University Hospital and Medical Center
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Buffalo, New York, États-Unis, 14263-0001
- Roswell Park Cancer Institute
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Manhasset, New York, États-Unis, 11030
- North Shore University Hospital
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New Hyde Park, New York, États-Unis, 11042
- Schneider Children's Hospital
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New York, New York, États-Unis, 10021
- Memorial Sloan-Kettering Cancer Center
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New York, New York, États-Unis, 10021
- New York Presbyterian Hospital - Cornell Campus
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New York, New York, États-Unis, 10029
- Mount Sinai School of Medicine
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New York, New York, États-Unis, 10032
- Columbia Presbyterian Hospital
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Rochester, New York, États-Unis, 14642
- University of Rochester Cancer Center
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Stony Brook, New York, États-Unis, 11790-7775
- State University of New York Health Sciences Center - Stony Brook
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Syracuse, New York, États-Unis, 13210
- State University of New York - Upstate Medical University
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Valhalla, New York, États-Unis, 10595
- New York Medical College
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North Carolina
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Asheville, North Carolina, États-Unis, 28801
- Mission Saint Joseph's Health System
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Chapel Hill, North Carolina, États-Unis, 27599-7295
- Lineberger Comprehensive Cancer Center, UNC
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Charlotte, North Carolina, États-Unis, 28232-2861
- Carolinas Medical Center
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Charlotte, North Carolina, États-Unis, 28233-3549
- Presbyterian Healthcare
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Durham, North Carolina, États-Unis, 27710
- Duke Comprehensive Cancer Center
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Greenville, North Carolina, États-Unis, 27858-4354
- East Carolina University School of Medicine
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North Dakota
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Fargo, North Dakota, États-Unis, 58108-6001
- Dakota Cancer Institute
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Ohio
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Akron, Ohio, États-Unis, 44308
- Children's Hospital Medical Center of Akron
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Cincinnati, Ohio, États-Unis, 45229-3039
- Children's Hospital Medical Center - Cincinnati
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Cleveland, Ohio, États-Unis, 44195
- Cleveland Clinic Taussig Cancer Center
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Cleveland, Ohio, États-Unis, 44106-5065
- Ireland Cancer Center
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Columbus, Ohio, États-Unis, 43205-2696
- Children's Hospital of Columbus
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Dayton, Ohio, États-Unis, 45404
- Children's Medical Center - Dayton
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Toledo, Ohio, États-Unis, 43601
- Toledo Children's Hospital
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Toledo, Ohio, États-Unis, 43608
- St. Vincent Mercy Medical Center
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Youngstown, Ohio, États-Unis, 44501
- Forum Health-Tod Childrens Hospital
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Oklahoma
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Oklahoma City, Oklahoma, États-Unis, 73104
- Children's Hospital of Oklahoma
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Tulsa, Oklahoma, États-Unis, 74136
- Natalie Warren Bryant Cancer Center
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Oregon
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Portland, Oregon, États-Unis, 97201-3098
- Doernbecher Children's Hospital
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Portland, Oregon, États-Unis, 97227
- Legacy Emanuel Hospital and Health Center
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Pennsylvania
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Danville, Pennsylvania, États-Unis, 17822-2001
- Geisinger Medical Center
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Hershey, Pennsylvania, États-Unis, 17033-0850
- Milton S. Hershey Medical Center
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Philadelphia, Pennsylvania, États-Unis, 19104
- Children's Hospital of Philadelphia
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Philadelphia, Pennsylvania, États-Unis, 19134-1095
- St. Christopher's Hospital for Children
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Pittsburgh, Pennsylvania, États-Unis, 15213
- Children's Hospital of Pittsburgh
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Rhode Island
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Providence, Rhode Island, États-Unis, 02903
- Rhode Island Hospital
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South Carolina
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Charleston, South Carolina, États-Unis, 29425-0721
- Medical University of South Carolina
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Columbia, South Carolina, États-Unis, 29203
- Center for Cancer Treatment and Research
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Greenville, South Carolina, États-Unis, 29605
- Children's Hospital of Greenville Hospital System
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South Dakota
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Sioux Falls, South Dakota, États-Unis, 57105
- Avera Cancer Institute
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Sioux Falls, South Dakota, États-Unis, 57117
- Sioux Valley Hospital
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Tennessee
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Johnson City, Tennessee, États-Unis, 37614-0622
- James H. Quillen College of Medicine
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Knoxville, Tennessee, États-Unis, 37901
- East Tennessee Children's Hospital
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Memphis, Tennessee, États-Unis, 38105-2794
- Saint Jude Children's Research Hospital
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Nashville, Tennessee, États-Unis, 37232-6838
- Vanderbilt-Ingram Cancer Center
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Texas
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Amarillo, Texas, États-Unis, 79106
- Texas Tech University Health Sciences Center School of Medicine
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Austin, Texas, États-Unis, 78701
- Children's Hospital of Austin
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Dallas, Texas, États-Unis, 75230
- Medical City Dallas Hospital
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Dallas, Texas, États-Unis, 75235-9154
- Simmons Cancer Center - Dallas
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Fort Worth, Texas, États-Unis, 76104
- Cook Children's Medical Center - Fort Worth
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Galveston, Texas, États-Unis, 77555-0209
- University of Texas Medical Branch
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Houston, Texas, États-Unis, 77030
- Baylor College of Medicine
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Houston, Texas, États-Unis, 77030-4009
- University of Texas - MD Anderson Cancer Center
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Lackland Air Force Base, Texas, États-Unis, 78236-5300
- San Antonio Military Pediatric Cancer and Blood Disorders Center
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Lubbock, Texas, États-Unis, 79410
- Covenant Children's Hospital
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San Antonio, Texas, États-Unis, 78284-7811
- University of Texas Health Science Center at San Antonio
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San Antonio, Texas, États-Unis, 78229
- Methodist Health Care System
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Temple, Texas, États-Unis, 76508
- Scott and White Memorial Hospital
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Vermont
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Burlington, Vermont, États-Unis, 05401-3498
- Vermont Cancer Center
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Virginia
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Charlottesville, Virginia, États-Unis, 22908
- Cancer Center at the University of Virginia
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Falls Church, Virginia, États-Unis, 22042-3300
- Inova Fairfax Hospital
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Norfolk, Virginia, États-Unis, 23507
- Children's Hospital of The King's Daughters
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Portsmouth, Virginia, États-Unis, 23708-2197
- Naval Medical Center, Portsmouth
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Richmond, Virginia, États-Unis, 23298-0037
- Massey Cancer Center
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Roanoke, Virginia, États-Unis, 24013
- Carilion Roanoke Community Hospital
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Washington
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Seattle, Washington, États-Unis, 98105
- Children's Hospital and Regional Medical Center - Seattle
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Seattle, Washington, États-Unis, 98109-1024
- Fred Hutchinson Cancer Research Center
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Seattle, Washington, États-Unis, 98112
- Group Health Cooperative of Puget Sound
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Spokane, Washington, États-Unis, 99210-0248
- Deaconess Medical Center
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Tacoma, Washington, États-Unis, 98431-5000
- Madigan Army Medical Center
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Tacoma, Washington, États-Unis, 98405
- Mary Bridge Children's Health Center
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West Virginia
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Charleston, West Virginia, États-Unis, 25302
- West Virginia University - Charleston
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Huntington, West Virginia, États-Unis, 25701
- Cabell-Huntington Hospital, Inc
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Morgantown, West Virginia, États-Unis, 26506-9300
- West Virginia University Hospitals
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Wisconsin
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Green Bay, Wisconsin, États-Unis, 54307-3508
- St. Vincent Hospital
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Green Bay, Wisconsin, États-Unis, 54301
- Bellin Memorial Hospital
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La Crosse, Wisconsin, États-Unis, 54601
- Gundersen Lutheran Medical Center
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Madison, Wisconsin, États-Unis, 53792-0001
- University of Wisconsin Hospital and Clinics
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Milwaukee, Wisconsin, États-Unis, 53226
- Midwest Children's Cancer Center
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Critères de participation
Les chercheurs recherchent des personnes qui correspondent à une certaine description, appelée critères d'éligibilité. Certains exemples de ces critères sont l'état de santé général d'une personne ou des traitements antérieurs.
Critère d'éligibilité
Âges éligibles pour étudier
Pas plus vieux que 21 ans (Enfant, Adulte)
Accepte les volontaires sains
Non
Sexes éligibles pour l'étude
Tout
La description
DISEASE CHARACTERISTICS: Histologically confirmed recurrent or refractory solid malignant tumors of childhood including: Soft tissue sarcoma Rhabdomyosarcoma Nonrhabdomyosarcoma Extraosseous Ewing's sarcoma CNS tumors Astrocytoma Primitive neuroectodermal tumor Atypical teratoid/rhabdoid tumors Ependymoma Recurrent neuroblastoma Measurable disease No more than 2 prior treatment regimens
PATIENT CHARACTERISTICS: Age: 21 and under at diagnosis Performance status: ECOG 0-2 Life expectancy: At least 2 months Hematopoietic: For patients with solid tumors (unless marrow involvement): Absolute neutrophil count (ANC) at least 1000/mm3 Platelet count at least 100,000/mm3 (transfusion independent) Hemoglobin at least 10 g/dL (RBC transfusions allowed) For patients post bone marrow transplantation: ANC at least 1,000/mm3 Platelet count at least 50,000/mm3 (transfusion independent) Hemoglobin at least 10 g/dL (RBC transfusions allowed) Hepatic: Total bilirubin no greater than 1.5 times normal SGOT/SGPT less than 2.5 times normal Renal: Creatinine no greater than 1.5 times normal OR Creatinine clearance or radioisotope glomerular filtration rate at least 70 mL/min Neurologic: Seizure disorder allowed if well controlled CNS toxicity no greater than grade 2
PRIOR CONCURRENT THERAPY: Biologic therapy: At least 6 months since prior bone marrow transplantation No concurrent immunomodulating agents Chemotherapy: At least 2 weeks since prior chemotherapy (4 weeks for nitrosourea) and recovered No other concurrent chemotherapy Endocrine therapy: No concurrent corticosteroids except for increased intracranial pressure due to CNS tumors Radiotherapy: At least 6 months since prior radiotherapy to craniospinal axis, spine, and/or more than 50% of the bony pelvis Concurrent radiotherapy to localized painful lesions allowed if at least one measurable lesion is not in radiation field Surgery: Not specified Other: No concurrent participation in another CCG, POG, or COG therapeutic study
Plan d'étude
Cette section fournit des détails sur le plan d'étude, y compris la façon dont l'étude est conçue et ce que l'étude mesure.
Comment l'étude est-elle conçue ?
Détails de conception
- Objectif principal: Traitement
Armes et Interventions
Groupe de participants / Bras |
Intervention / Traitement |
|---|---|
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Expérimental: Stratum 1 - Soft Tissue Sarcoma
See detailed description.
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Autres noms:
|
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Expérimental: Stratum 2 - CNS Tumors
See detailed description.
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Autres noms:
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Expérimental: Stratum 3 - Neuroblastoma
See detailed description.
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Autres noms:
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Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
|---|
|
Progression de la maladie
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Collaborateurs et enquêteurs
C'est ici que vous trouverez les personnes et les organisations impliquées dans cette étude.
Parrainer
Collaborateurs
Les enquêteurs
- Chaise d'étude: John F. Kuttesch, PhD, MD, M.D. Anderson Cancer Center
Publications et liens utiles
La personne responsable de la saisie des informations sur l'étude fournit volontairement ces publications. Il peut s'agir de tout ce qui concerne l'étude.
Dates d'enregistrement des études
Ces dates suivent la progression des dossiers d'étude et des soumissions de résultats sommaires à ClinicalTrials.gov. Les dossiers d'étude et les résultats rapportés sont examinés par la Bibliothèque nationale de médecine (NLM) pour s'assurer qu'ils répondent à des normes de contrôle de qualité spécifiques avant d'être publiés sur le site Web public.
Dates principales de l'étude
Début de l'étude
1 mai 1998
Achèvement primaire (Réel)
1 mars 2006
Achèvement de l'étude (Réel)
1 mars 2007
Dates d'inscription aux études
Première soumission
1 novembre 1999
Première soumission répondant aux critères de contrôle qualité
27 octobre 2003
Première publication (Estimation)
28 octobre 2003
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Estimation)
28 juillet 2014
Dernière mise à jour soumise répondant aux critères de contrôle qualité
25 juillet 2014
Dernière vérification
1 juillet 2014
Plus d'information
Termes liés à cette étude
Mots clés
- rhabdomyosarcome infantile récurrent
- neuroblastome récurrent
- sarcome d'Ewing récurrent/tumeur neuroectodermique primitive périphérique
- tumeur neuroectodermique primitive sus-tentorielle récidivante de l'enfant
- astrocytome cérébelleux infantile récurrent
- astrocytome cérébral infantile récurrent
- épendymome infantile récurrent
- sarcome récurrent des tissus mous de l'enfant
Termes MeSH pertinents supplémentaires
- Maladies du système nerveux
- Tumeurs, tissus conjonctifs et mous
- Tumeurs par type histologique
- Tumeurs
- Tumeurs par site
- Tumeurs, glandulaires et épithéliales
- Tumeurs, neuroépithéliales
- Tumeurs neuroectodermiques
- Tumeurs, cellules germinales et embryonnaires
- Tumeurs, tissu nerveux
- Tumeurs neuroectodermiques primitives
- Tumeurs neuroectodermiques, primitives, périphériques
- Sarcome
- Tumeurs du système nerveux
- Tumeurs du système nerveux central
- Neuroblastome
- Mécanismes moléculaires de l'action pharmacologique
- Agents antinéoplasiques
- Modulateurs de tubuline
- Agents antimitotiques
- Modulateurs de mitose
- Agents antinéoplasiques phytogéniques
- Vinorelbine
Autres numéros d'identification d'étude
- A09705
- COG-A09705 (Autre identifiant: Children's Oncology Group)
- CCG-09705 (Autre identifiant: Children's Cancer Group)
- CDR0000066106 (Autre identifiant: Clinical Trials.gov)
Ces informations ont été extraites directement du site Web clinicaltrials.gov sans aucune modification. Si vous avez des demandes de modification, de suppression ou de mise à jour des détails de votre étude, veuillez contacter register@clinicaltrials.gov. Dès qu'un changement est mis en œuvre sur clinicaltrials.gov, il sera également mis à jour automatiquement sur notre site Web .
Essais cliniques sur tartrate de vinorelbine
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National Cancer Institute, SlovakiaRetiréCancer du sein métastatiqueSlovaquie