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The Body's Response to Food Intake in Trained, Older Adults

23. september 2013 opdateret af: Wayne Campbell, Purdue University
The purpose of this research study is to determine the effects of food supplements and strength training on appetite, the amount of energy expended, and body composition.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

50

Fase

  • Ikke anvendelig

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Forenede Stater
    • Indiana
      • West Lafayette, Indiana, Forenede Stater, 47907
        • Purdue University

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

60 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ja

Køn, der er berettiget til at studere

Alle

Beskrivelse

Inclusion Criteria:

All subjects must meet the following eligibility criteria:

  • Age range: 60 years and older
  • Body mass index between 20-29 kg/m2
  • Weight stable (< 2 kg weight change within last 6 months)
  • Non-smoking
  • Constant habitual activity patterns within last 3 months
  • Clinically normal blood profiles (specifically, normal liver and kidney function; normal complete blood count (non-anemic); fasting blood glucose <110 mg/dl)
  • Not taking medications known to influence appetite or metabolism
  • Non-diabetic
  • Confirmation of acceptability of eating the study test foods (solids and fluids)

Trained subjects (Recruiting 36; N-25) must meet the following eligibility criteria:

  • Resistive exercise training (≥ 2 times a week) based on reported physical activity levels (questionnaire)
  • Active fitness level (≥ 2, 30-minute aerobic exercise sessions/week)

Sedentary subjects (Recruiting 36; N-25) must meet the following eligibility criteria:

  • Resistive exercise training (≤ 1 time a week) based on reported physical activity levels (questionnaire)
  • Active fitness level (≤ 2, 30-minute aerobic exercise sessions/week)

Exclusion Criteria:

All subjects will be excluded based on the following exclusionary criteria:

  • Age: <60 years
  • Body mass index: outside of the 20-29 kg/m2 range
  • Gained or lost > 4.5 kg within the last 6 months
  • Smoker (currently or within the last year)
  • Intermittently been involved in a diet and/or exercise program within the last 3 months
  • Clinically abnormal blood profiles as identified by our study physician, Arthur Rosen, MD
  • Taking medications (currently or within the last 3 months) known to influence appetite or metabolism
  • Abnormal heart function (interpreted by a cardiologist) and assessed (for study exclusion) by our study physician, Arthur Rosen, MD
  • Clinically diagnosed as diabetic
  • Study foods are found to be unacceptable for consumption by the subject
  • Clinically diagnosed osteoporosis

Trained subjects will be excluded based on the following exclusionary criteria:

  • Did not perform resistive exercise training (currently or within the last 3 months) based on reported physical activity levels (questionnaire)
  • Perform ≤ 1, 30-minute aerobic exercise session/week (currently or within the last 3 months) based on physical activity levels questionnaire)

Sedentary subjects will be excluded based on the following exclusionary criteria:

  • Performed resistive exercise training (currently or within the last 3 months) based on reported physical activity levels (questionnaire)
  • Perform > 2, 30-minute aerobic exercise sessions/week (currently or within the last 3 months) based on physical activity levels questionnaire)

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Forebyggelse
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Ingen (Åben etiket)

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Eksperimentel: 1
participants continue current exercise and take liquid supplement
Kosttilskud: Liquid Supplements
Liquid supplement that provides 12.5% of the subjects total energy requirement.
Eksperimentel: 2
Participants continue current exercise and take solid supplement
Kosttilskud: Solid Supplement
Solid supplement that provides 12.5% of the subjects total energy requirement.
Eksperimentel: 3
Participants continue current sedentary behavior and take liquid supplements
Kosttilskud: Liquid Supplements
Liquid supplement that provides 12.5% of the subjects total energy requirement.
Eksperimentel: 4
Participants continue current sedentary behavior and take solid supplements
Kosttilskud: Solid Supplement
Solid supplement that provides 12.5% of the subjects total energy requirement.

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Tidsramme
Quantify the acute effects of fluid and solid foods on post-prandial (post-meal) appetite and food intake at the next eating occasion in trained and untrained, elderly people.
Tidsramme: 6 weeks
6 weeks

Sekundære resultatmål

Resultatmål
Tidsramme
Quantify the contribution of selected satiety factors (glucose, insulin, CCK, ghrelin, and GLP-1) and gastrointestinal transit time, to the differential appetitive responses to fluid versus solid foods in trained and untrained, elderly people
Tidsramme: 6 weeks
6 weeks

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Purdue University

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart

1. september 2006

Primær færdiggørelse (Faktiske)

1. august 2007

Studieafslutning (Faktiske)

1. maj 2008

Datoer for studieregistrering

Først indsendt

25. november 2008

Først indsendt, der opfyldte QC-kriterier

25. november 2008

Først opslået (Skøn)

26. november 2008

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Skøn)

24. september 2013

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

23. september 2013

Sidst verificeret

1. marts 2010

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Andre undersøgelses-id-numre

  • 0607004184
  • NIH R01 AG021911-0102

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

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