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Rosuvastatin til behandling af patienter med trin I eller trin II tyktarmskræft, der blev fjernet ved kirurgi

27. juli 2023 opdateret af: NSABP Foundation Inc

Statinpolyp-forebyggelsesforsøg hos patienter med resekeret tyktarmskræft

RATIONALE: Rosuvastatin kan stoppe væksten af ​​tumorceller ved at blokere nogle af de enzymer, der er nødvendige for cellevækst. At give rosuvastatin efter operationen kan dræbe eventuelle tumorceller, der er tilbage efter operationen. Det kan også forhindre polypper i at dannes eller tyktarmskræft i at komme tilbage. Det vides endnu ikke, om rosuvastatin er mere effektivt end placebo til behandling af tyktarmskræft, som blev fjernet ved operation.

FORMÅL: Dette randomiserede fase III-forsøg studerer rosuvastatin for at se, hvor godt det virker sammenlignet med placebo til behandling af patienter med stadium I eller stadium II tyktarmskræft, der blev fjernet ved operation.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

MÅL:

Primær

  • For at sammenligne virkningen af ​​rosuvastatin vs placebo på 5-års forekomsten af ​​adenomatøse polypper i tyktarmen eller rektum, metakront kolorektalt karcinom eller recidiv af tyktarmskræft (APMC+R) hos patienter med resekeret stadium I eller II tyktarmskræft.

Sekundær

  • For at bestemme, om effekten af ​​rosuvastatin versus placebo er af samme størrelsesorden hos patienter, der tager aspirin (uanset dosis) sammenlignet med patienter, der ikke tager aspirin.
  • For at afgøre, om indtagelse af aspirin (uanset dosis) vs. ingen aspirin vil mindske forekomsten eller APMC+R og, hvis der er en effekt, at undersøge forholdet til dosis.
  • For at bestemme effekten af ​​rosuvastatin hos patienter med familiær kolorektal cancer.
  • For at bestemme effekten af ​​rosuvastatin hos patienter med mikrosatellit-ustabile tumorer (dvs. tumorer, der viser tab af MLH1- eller MSH2-ekspression af IHC).
  • At bestemme forholdet mellem rosuvastatinbehandling og træk ved kolorektale adenomer samt størrelsen og antallet af kolorektale adenomer.
  • At sammenligne tiden til APMC+R hos patienter behandlet med rosuvastatin vs. placebo.
  • At sammenligne den sygdomsfrie overlevelse af patienter behandlet med rosuvastatin vs placebo.
  • At sammenligne den samlede overlevelse af patienter behandlet med rosuvastatin vs placebo.
  • At sammenligne frekvensen af ​​recidiv af tyktarmskræft hos patienter behandlet med rosuvastatin versus placebo.
  • At sammenligne antallet af sekundære ikke-kolorektale primære kræftformer hos patienter behandlet med rosuvastatin vs. placebo.
  • At bestemme effekten af ​​rosuvastatin på sundhedsrelateret livskvalitet, global livskvalitet og selvrapporterede symptomer.
  • At sammenligne forekomsten og sværhedsgraden af ​​bivirkninger forbundet med rosuvastatin versus placebo.
  • At vurdere relevante tumor- og blodmarkører, der kan påvirke metabolismen, aktiviteten eller effekten af ​​undersøgelseslægemidlerne, såsom HMG-CoA-reduktase, UGT1A6, P450-2C9, PTGS2 (COX-2) og andre mulige markører.

OVERSIGT: Dette er en multicenterundersøgelse. Patienterne stratificeres efter familiehistorie for en førstegradsslægtning med kolorektal cancer (ja vs nej), tilsigtet aspirindosis (ingen vs 81 mg vs 325 mg) og adjuverende behandling for tyktarmskræft (ja vs nej). Patienterne randomiseres til 1 ud af 2 behandlingsarme.

  • Gruppe 1: Patienter får oral placebo én gang dagligt i 5 år.
  • Gruppe 2: Patienterne får oralt rosuvastatin én gang dagligt i 5 år.

Patienter kan udfylde et livskvalitetsspørgeskema ved baseline og efter 6, 12, 36, 60 og 84 måneder.

Tumorvævs-, serum- og blodprøver kan udtages periodisk til biomarkør- og andre analyser.

Efter afsluttet undersøgelsesbehandling følges patienterne periodisk i op til 2 år.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

406

Fase

  • Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Canada
    • Ontario
      • Kingston, Ontario, Canada, K7L 5P9
        • Cancer Centre of Southeastern Ontario at Kingston General Hospital
    • Quebec
      • Montreal, Quebec, Canada, H3A 1A1
        • Royal Victoria Hospital - Montreal
      • Quebec City, Quebec, Canada, G1S 4L8
        • Hopital du Saint-Sacrement - Quebec
  • Forenede Stater
    • Alabama
      • Anniston, Alabama, Forenede Stater, 36207
        • Regional Medical Center
      • Mobile, Alabama, Forenede Stater, 36608
        • Providence Cancer Center at Providence Hospital
    • Arkansas
      • Fort Smith, Arkansas, Forenede Stater, 72903
        • Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
      • Little Rock, Arkansas, Forenede Stater, 72205
        • Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
      • Little Rock, Arkansas, Forenede Stater, 72205
    • California
      • Anaheim, California, Forenede Stater, 92807
        • Kaiser Permanente Medical Center - Anaheim/Orange County
      • Antioch, California, Forenede Stater, 94531
        • Kaiser Permanente - Deer Valley
      • Baldwin Park, California, Forenede Stater, 91706
        • Kaiser Permanente Medical Center - Baldwin Park
      • Bellflower, California, Forenede Stater, 90706
        • Kaiser Permanente Medical Center - Bellflower
      • Castro Valley, California, Forenede Stater, 94546
        • East Bay Radiation Oncology Center
      • Castro Valley, California, Forenede Stater, 94546
        • Valley Medical Oncology Consultants - Castro Valley
      • Fairfield, California, Forenede Stater, 94533
        • North Bay Cancer Center
      • Fontana, California, Forenede Stater, 92335
        • Kaiser Permanente Medical Center - Fontana
      • Fremont, California, Forenede Stater, 94538
        • Kaiser Permanente - Fremont
      • Fremont, California, Forenede Stater, 94538
        • Valley Medical Oncology
      • Fullerton, California, Forenede Stater, 92835
        • Virginia K. Crosson Cancer Center At St. Jude Medical Center
      • Glendale, California, Forenede Stater, 91204
        • Glendale Memorial Hospital Comprehensive Cancer Center
      • Harbor City, California, Forenede Stater, 90710
        • Kaiser Permanente Medical Center - Harbor City
      • Hayward, California, Forenede Stater, 94545
        • Kaiser Permanente Medical Center - Hayward
      • Irvine, California, Forenede Stater, 92618
        • Kaiser Permanente - Irvine
      • Los Angeles, California, Forenede Stater, 90027
        • Kaiser Permanente Medical Center - Los Angeles
      • Los Angeles, California, Forenede Stater, 90034
        • Kaiser Foundation Hospital - West Los Angeles
      • Martinez, California, Forenede Stater, 94553-3156
        • Contra Costa Regional Medical Center
      • Modesto, California, Forenede Stater, 95355
        • Memorial Medical Center
      • Mountain View, California, Forenede Stater, 94040
        • El Camino Hospital Cancer Center
      • Mountain View, California, Forenede Stater, 94040
        • Camino Medical Group - Treatment Center
      • Oakland, California, Forenede Stater, 94609
        • Alta Bates Summit Medical Center - Summit Campus
      • Oakland, California, Forenede Stater, 94602
        • Highland General Hospital
      • Oakland, California, Forenede Stater, 94609
        • Larry G Strieff MD Medical Corporation
      • Oakland, California, Forenede Stater, 94609
        • CCOP - Bay Area Tumor Institute
      • Oakland, California, Forenede Stater, 94609
        • Bay Area Breast Surgeons, Incorporated
      • Oakland, California, Forenede Stater, 94609
        • Tom K Lee, Incorporated
      • Oakland, California, Forenede Stater, 94611
        • Kaiser Permanente Medical Center - Oakland
      • Oakland, California, Forenede Stater, 94612
        • Epic Care - Oakland
      • Ontario, California, Forenede Stater, 91761
        • Kaiser Permanente - Ontario Vineyard Medical Offices and Ambulatory SurgiCenter
      • Orange, California, Forenede Stater, 92868
        • St. Joseph Hospital Regional Cancer Center - Orange
      • Palo Alto, California, Forenede Stater, 94301
        • Palo Alto Medical Foundation
      • Panorama City, California, Forenede Stater, 91402
        • Kaiser Permanente Medical Group
      • Rancho Mirage, California, Forenede Stater, 92270
        • Lucy Curci Cancer Center at Eisenhower Memorial Hospital and Medical Center
      • Redwood City, California, Forenede Stater, 94063
        • Kaiser Permanente Medical Center - Redwood City
      • Richmond, California, Forenede Stater, 94801
        • Kaiser Permanente Medical Center - Richmond
      • Riverside, California, Forenede Stater, 92505
        • Kaiser Permanente Medical Center - Riverside
      • Roseville, California, Forenede Stater, 95661
        • Kaiser Permanente Medical Center - Roseville
      • Sacramento, California, Forenede Stater, 95823
        • South Sacramento Kaiser-Permanente Medical Center
      • Sacramento, California, Forenede Stater, 95825
        • Kaiser Permanente Medical Center - Sacramento
      • Salinas, California, Forenede Stater, 93901
        • Salinas Valley Memorial Hospital
      • San Diego, California, Forenede Stater, 92120
        • Kaiser Permanente Medical Center - Kaiser Foundation Hospital - San Diego
      • San Diego, California, Forenede Stater, 92108
        • Kaiser Permanente Medical Office -Vandever Medical Office
      • San Francisco, California, Forenede Stater, 94115
        • Kaiser Permanente Medical Center - San Francisco Geary Campus
      • San Jose, California, Forenede Stater, 95119
        • Kaiser Permanente Medical Center - Santa Teresa
      • San Marcos, California, Forenede Stater, 92078
        • Kaiser Permanente Health Care
      • San Pablo, California, Forenede Stater, 94806
        • Doctors Medical Center - San Pablo Campus
      • San Rafael, California, Forenede Stater, 94903
        • Kaiser Foundation Hospital - San Rafael
      • Santa Clara, California, Forenede Stater, 95051
        • Kaiser Permanente Medical Center - Santa Clara Kiely Campus
      • Santa Rosa, California, Forenede Stater, 95403
        • Kaiser Permanente Medical Center - Santa Rosa
      • South San Francisco, California, Forenede Stater, 94080
        • Kaiser Permanente Medical Center - South San Francisco
      • Stanford, California, Forenede Stater, 94305-5824
        • Stanford Cancer Center
      • Stockton, California, Forenede Stater, 95210
        • Kaiser Permanente Medical Facility - Stockton
      • Vacaville, California, Forenede Stater, 95688
        • Kaiser Permanente Medical Center - Vacaville
      • Vallejo, California, Forenede Stater, 94589
        • Kaiser Permanente Medical Center - Vallejo
      • Walnut Creek, California, Forenede Stater, 94596
        • Kaiser Permanente Medical Center - Walnut Creek
      • Woodland Hills, California, Forenede Stater, 91367
        • Kaiser Permanente Medical Cener - Woodland Hills
    • Colorado
      • Aurora, Colorado, Forenede Stater, 80012
        • Aurora Presbyterian Hospital
      • Boulder, Colorado, Forenede Stater, 80301-9019
        • Boulder Community Hospital
      • Colorado Springs, Colorado, Forenede Stater, 80933
        • Penrose Cancer Center at Penrose Hospital
      • Denver, Colorado, Forenede Stater, 80210
        • Porter Adventist Hospital
      • Denver, Colorado, Forenede Stater, 80220
        • Rose Medical Center
      • Denver, Colorado, Forenede Stater, 80218
        • Presbyterian - St. Luke's Medical Center
      • Denver, Colorado, Forenede Stater, 80204
        • St. Anthony Central Hospital
      • Denver, Colorado, Forenede Stater, 80218
        • St. Joseph Hospital
      • Denver, Colorado, Forenede Stater, 80222
        • CCOP - Colorado Cancer Research Program
      • Denver, Colorado, Forenede Stater, 80205
        • Kaiser Permanente - Denver
      • Englewood, Colorado, Forenede Stater, 80110
        • Swedish Medical Center
      • Fort Collins, Colorado, Forenede Stater, 80524
        • Poudre Valley Hospital
      • Fort Collins, Colorado, Forenede Stater, 80528
        • Front Range Cancer Specialists
      • Grand Junction, Colorado, Forenede Stater, 81502
        • St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
      • Greeley, Colorado, Forenede Stater, 80631
        • North Colorado Medical Center
      • Lafayette, Colorado, Forenede Stater, 80026
        • Kaiser Permanente - Lafayette
      • Littleton, Colorado, Forenede Stater, 80122
        • Littleton Adventist Hospital
      • Lone Tree, Colorado, Forenede Stater, 80124
        • Sky Ridge Medical Center
      • Longmont, Colorado, Forenede Stater, 80501
        • Hope Cancer Care Center at Longmont United Hospital
      • Loveland, Colorado, Forenede Stater, 80539
        • McKee Medical Center
      • Parker, Colorado, Forenede Stater, 80138
        • Parker Adventist Hospital
      • Pueblo, Colorado, Forenede Stater, 81004
        • St. Mary - Corwin Regional Medical Center
      • Thornton, Colorado, Forenede Stater, 80229
        • North Suburban Medical Center
      • Wheat Ridge, Colorado, Forenede Stater, 80033
        • Exempla Lutheran Medical Center
    • Connecticut
      • Farmington, Connecticut, Forenede Stater, 06360-2875
        • Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center
      • Greenwich, Connecticut, Forenede Stater, 06830
        • Bendheim Cancer Center at Greenwich Hospital
      • Hartford, Connecticut, Forenede Stater, 06105
        • Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
      • Hartford, Connecticut, Forenede Stater, 06102-5037
        • Helen and Harry Gray Cancer Center at Hartford Hospital
      • Middletown, Connecticut, Forenede Stater, 06457
        • Middlesex Hospital Cancer Center
      • Stamford, Connecticut, Forenede Stater, 06904
        • Carl and Dorothy Bennett Cancer Center at Stamford Hospital
    • Delaware
      • Dover, Delaware, Forenede Stater, 19901
        • Kent General Hospital
      • Lewes, Delaware, Forenede Stater, 19958
        • Tunnell Cancer Center at Beebe Medical Center
      • Newark, Delaware, Forenede Stater, 19713
        • CCOP - Christiana Care Health Services
    • District of Columbia
      • Washington, District of Columbia, Forenede Stater, 20010
        • Washington Cancer Institute at Washington Hospital Center
      • Washington, District of Columbia, Forenede Stater, 20002
        • Kaiser Permanente at Capitol Hill Medical Center
    • Florida
      • Fort Lauderdale, Florida, Forenede Stater, 33308
        • Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
      • Gainesville, Florida, Forenede Stater, 32610-0232
        • University of Florida Shands Cancer Center
      • Jacksonville, Florida, Forenede Stater, 32204
        • St. Vincent's Medical Center
      • Jacksonville, Florida, Forenede Stater, 32207
        • Baptist Cancer Institute - Jacksonville
      • Jupiter, Florida, Forenede Stater, 33458
        • Ella Milbank Foshay Cancer Center at Jupiter Medical Center
      • Miami Beach, Florida, Forenede Stater, 33140
        • CCOP - Mount Sinai Medical Center
      • Sarasota, Florida, Forenede Stater, 34236
        • Florida Cancer Specialists - Sarasota Downtown
      • Weston, Florida, Forenede Stater, 33331
        • Cleveland Clinic Florida - Weston
    • Georgia
      • Albany, Georgia, Forenede Stater, 31701
        • Phoebe Cancer Center at Phoebe Putney Memorial Hospital
      • Atlanta, Georgia, Forenede Stater, 30309
        • Piedmont Hospital
      • Atlanta, Georgia, Forenede Stater, 30342-1611
        • Northside Hospital Cancer Center
      • Atlanta, Georgia, Forenede Stater, 30342-1701
        • Saint Joseph's Hospital of Atlanta
      • Atlanta, Georgia, Forenede Stater, 30342
        • CCOP - Atlanta Regional
      • Augusta, Georgia, Forenede Stater, 30912
        • MBCCOP - Medical College of Georgia Cancer Center
      • Austell, Georgia, Forenede Stater, 30106
        • WellStar Cobb Hospital
      • Columbus, Georgia, Forenede Stater, 31904
        • John B. Amos Cancer Center
      • Decatur, Georgia, Forenede Stater, 30033
        • Charles B. Eberhart Cancer Center at DeKalb Medical Center
      • Fayetteville, Georgia, Forenede Stater, 30214
        • Piedmont Fayette Hospital
      • Lawrenceville, Georgia, Forenede Stater, 30045
        • Gwinnett Medical Center
      • Marietta, Georgia, Forenede Stater, 30060
        • Kennestone Cancer Center at Wellstar Kennestone Hospital
      • Riverdale, Georgia, Forenede Stater, 30274-2600
        • Southern Regional Medical Center
      • Rome, Georgia, Forenede Stater, 30165
        • Harbin Clinic Cancer Center - Medical Oncology
      • Savannah, Georgia, Forenede Stater, 31405
        • Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
    • Hawaii
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Cancer Research Center of Hawaii
      • Honolulu, Hawaii, Forenede Stater, 96813
        • OnCare Hawaii, Incorporated - Lusitana
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Queen's Cancer Institute at Queen's Medical Center
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Straub Clinic and Hospital, Incorporated
      • Honolulu, Hawaii, Forenede Stater, 96817
        • OnCare Hawaii, Incorporated - Kuakini
      • Honolulu, Hawaii, Forenede Stater, 96859
        • Tripler Army Medical Center
      • Honolulu, Hawaii, Forenede Stater, 96819
        • Kaiser Permanente - Moanalua Medical Center and Clinic
    • Idaho
      • Boise, Idaho, Forenede Stater, 83706
        • Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
      • Lewiston, Idaho, Forenede Stater, 83501
        • St. Joseph Regional Medical Center
    • Illinois
      • Aurora, Illinois, Forenede Stater, 60504
        • Rush-Copley Cancer Care Center
      • Bloomington, Illinois, Forenede Stater, 61701
        • Illinois CancerCare - Bloomington
      • Bloomington, Illinois, Forenede Stater, 61701
        • St. Joseph Medical Center
      • Canton, Illinois, Forenede Stater, 61520
        • Illinois CancerCare - Canton
      • Canton, Illinois, Forenede Stater, 61520
        • Graham Hospital
      • Carthage, Illinois, Forenede Stater, 62321
        • Memorial Hospital
      • Carthage, Illinois, Forenede Stater, 62321
        • Illinois CancerCare - Carthage
      • Chicago, Illinois, Forenede Stater, 60640
        • Louis A. Weiss Memorial Hospital
      • Chicago, Illinois, Forenede Stater, 60608
        • Mount Sinai Hospital Medical Center
      • Chicago, Illinois, Forenede Stater, 60631
        • Resurrection Medical Center
      • Decatur, Illinois, Forenede Stater, 62526
        • Decatur Memorial Hospital Cancer Care Institute
      • Elgin, Illinois, Forenede Stater, 60123
        • Sherman Hospital
      • Elk Grove Village, Illinois, Forenede Stater, 60007
        • Alexian Brothers Radiation Oncology
      • Elmhurst, Illinois, Forenede Stater, 60126
        • Elmhurst Memorial Hospital
      • Eureka, Illinois, Forenede Stater, 61530
        • Illinois CancerCare - Eureka
      • Eureka, Illinois, Forenede Stater, 61530
        • Eureka Community Hospital
      • Galesburg, Illinois, Forenede Stater, 61401
        • Illinois CancerCare - Galesburg
      • Galesburg, Illinois, Forenede Stater, 61401
        • Galesburg Clinic, PC
      • Harvey, Illinois, Forenede Stater, 60426
        • Ingalls Cancer Care Center at Ingalls Memorial Hospital
      • Havana, Illinois, Forenede Stater, 62644
        • Mason District Hospital
      • Havana, Illinois, Forenede Stater, 62644
        • Illinois CancerCare - Havana
      • Hinsdale, Illinois, Forenede Stater, 60521
        • Hinsdale Hematology Oncology Associates
      • Joliet, Illinois, Forenede Stater, 60435
        • Joliet Oncology-Hematology Associates, Limited - West
      • Kewanee, Illinois, Forenede Stater, 61443
        • Illinois CancerCare - Kewanee Clinic
      • La Grange, Illinois, Forenede Stater, 60525
        • La Grange Memorial Hospital
      • Macomb, Illinois, Forenede Stater, 61455
        • Illinois CancerCare - Macomb
      • Macomb, Illinois, Forenede Stater, 61455
        • Mcdonough District Hospital
      • Moline, Illinois, Forenede Stater, 61265
      • Moline, Illinois, Forenede Stater, 61265
        • Trinity Cancer Center at Trinity Medical Center - 7th Street Campus
      • Monmouth, Illinois, Forenede Stater, 61462
        • Illinois CancerCare - Monmouth
      • Monmouth, Illinois, Forenede Stater, 61462
        • OSF Holy Family Medical Center
      • Naperville, Illinois, Forenede Stater, 60540
        • Edward Hospital Cancer Center
      • Normal, Illinois, Forenede Stater, 61761
        • Bromenn Regional Medical Center
      • Normal, Illinois, Forenede Stater, 61761
        • Community Cancer Center
      • Normal, Illinois, Forenede Stater, 61761
        • Illinois CancerCare - Community Cancer Center
      • Oak Lawn, Illinois, Forenede Stater, 60453-2699
        • Advocate Christ Medical Center
      • Ottawa, Illinois, Forenede Stater, 61350
        • Community Hospital of Ottawa
      • Ottawa, Illinois, Forenede Stater, 61350
        • Oncology Hematology Associates of Central Illinois, PC - Ottawa
      • Park Ridge, Illinois, Forenede Stater, 60068-1174
        • Advocate Lutheran General Cancer Care Center
      • Pekin, Illinois, Forenede Stater, 61554
        • Cancer Treatment Center at Pekin Hospital
      • Pekin, Illinois, Forenede Stater, 61603
        • Illinois CancerCare - Pekin
      • Peoria, Illinois, Forenede Stater, 61636
        • Methodist Medical Center of Illinois
      • Peoria, Illinois, Forenede Stater, 61614
        • Proctor Hospital
      • Peoria, Illinois, Forenede Stater, 61637
        • OSF St. Francis Medical Center
      • Peoria, Illinois, Forenede Stater, 61615
        • CCOP - Illinois Oncology Research Association
      • Peoria, Illinois, Forenede Stater, 61615
        • Oncology Hematology Associates of Central Illinois, PC - Peoria
      • Peru, Illinois, Forenede Stater, 61354
        • Illinois CancerCare - Peru
      • Peru, Illinois, Forenede Stater, 61354
        • Illinois Valley Community Hospital
      • Princeton, Illinois, Forenede Stater, 61356
        • Perry Memorial Hospital
      • Princeton, Illinois, Forenede Stater, 61356
        • Illinois CancerCare - Princeton
      • River Forest, Illinois, Forenede Stater, 60305
        • West Suburban Center for Cancer Care
      • Rockford, Illinois, Forenede Stater, 61104-2315
        • Swedish-American Regional Cancer Center
      • Rockford, Illinois, Forenede Stater, 61108
        • Center for Cancer Care at OSF Saint Anthony Medical Center
      • Spring Valley, Illinois, Forenede Stater, 61362
        • Illinois CancerCare - Spring Valley
      • Springfield, Illinois, Forenede Stater, 62781-0001
        • Regional Cancer Center at Memorial Medical Center
      • Urbana, Illinois, Forenede Stater, 61801
        • CCOP - Carle Cancer Center
    • Indiana
      • Beech Grove, Indiana, Forenede Stater, 46107
        • St. Francis Hospital and Health Centers - Beech Grove Campus
      • Elkhart, Indiana, Forenede Stater, 46515
        • Elkhart General Hospital
      • Elkhart, Indiana, Forenede Stater, 46514-2098
        • Elkhart Clinic, LLC
      • Elkhart, Indiana, Forenede Stater, 46514
        • Michiana Hematology-Oncology, PC - Elkhart
      • Indianapolis, Indiana, Forenede Stater, 46260
        • St. Vincent Indianapolis Hospital
      • Kokomo, Indiana, Forenede Stater, 46904
        • Howard Community Hospital
      • La Porte, Indiana, Forenede Stater, 46350
        • Center for Cancer Therapy at LaPorte Hospital and Health Services
      • Michigan City, Indiana, Forenede Stater, 46360
        • Saint Anthony Memorial Health Centers
      • Mishawaka, Indiana, Forenede Stater, 46545-1470
        • Michiana Hematology-Oncology, PC - South Bend
      • Mishawaka, Indiana, Forenede Stater, 46545-1470
        • Saint Joseph Regional Medical Center
      • Munster, Indiana, Forenede Stater, 46321
        • Community Hospital
      • Plymouth, Indiana, Forenede Stater, 46563
        • Michiana Hematology Oncology PC - Plymouth
      • Richmond, Indiana, Forenede Stater, 47374
        • Reid Hospital & Health Care Services
      • South Bend, Indiana, Forenede Stater, 46601
        • Memorial Hospital of South Bend
      • South Bend, Indiana, Forenede Stater, 46601
        • CCOP - Northern Indiana CR Consortium
      • Westville, Indiana, Forenede Stater, 46391
        • Michiana Hematology Oncology PC - La Porte
    • Iowa
      • Ames, Iowa, Forenede Stater, 50010
        • McFarland Clinic, PC
      • Bettendorf, Iowa, Forenede Stater, 52722
      • Bettendorf, Iowa, Forenede Stater, 52722
        • Hematology Oncology Associates of the Quad Cities
      • Cedar Rapids, Iowa, Forenede Stater, 52403
        • Cedar Rapids Oncology Associates
      • Cedar Rapids, Iowa, Forenede Stater, 52403
        • Mercy Regional Cancer Center at Mercy Medical Center
      • Clive, Iowa, Forenede Stater, 50325
        • Medical Oncology and Hematology Associates - West Des Moines
      • Clive, Iowa, Forenede Stater, 50325
        • Mercy Cancer Center - West Lakes
      • Davenport, Iowa, Forenede Stater, 52803
        • Genesis Regional Cancer Center at Genesis Medical Center
      • Des Moines, Iowa, Forenede Stater, 50309
        • CCOP - Iowa Oncology Research Association
      • Des Moines, Iowa, Forenede Stater, 50309
        • John Stoddard Cancer Center at Iowa Methodist Medical Center
      • Des Moines, Iowa, Forenede Stater, 50309
        • Medical Oncology and Hematology Associates at John Stoddard Cancer Center
      • Des Moines, Iowa, Forenede Stater, 50314
        • Medical Oncology and Hematology Associates at Mercy Cancer Center
      • Des Moines, Iowa, Forenede Stater, 50314
        • Mercy Cancer Center at Mercy Medical Center - Des Moines
      • Des Moines, Iowa, Forenede Stater, 50316
        • John Stoddard Cancer Center at Iowa Lutheran Hospital
      • Iowa City, Iowa, Forenede Stater, 52242-1002
        • Holden Comprehensive Cancer Center at University of Iowa
      • Mason City, Iowa, Forenede Stater, 50401
        • Mercy Cancer Center at Mercy Medical Center - North Iowa
      • Ottumwa, Iowa, Forenede Stater, 52501
        • McCreery Cancer Center at Ottumwa Regional
      • Sioux City, Iowa, Forenede Stater, 51101
        • Siouxland Hematology-Oncology Associates, LLP
      • Sioux City, Iowa, Forenede Stater, 51102
        • Mercy Medical Center - Sioux City
      • Sioux City, Iowa, Forenede Stater, 51104
        • St. Luke's Regional Medical Center
      • Waterloo, Iowa, Forenede Stater, 50702
        • Covenant Cancer Treatment Center
      • West Des Moines, Iowa, Forenede Stater, 50266-7700
        • Methodist West Hospital
    • Kansas
      • Chanute, Kansas, Forenede Stater, 66720
        • Cancer Center of Kansas, PA - Chanute
      • Dodge City, Kansas, Forenede Stater, 67801
        • Cancer Center of Kansas, PA - Dodge City
      • El Dorado, Kansas, Forenede Stater, 67042
        • Cancer Center of Kansas, PA - El Dorado
      • Fort Scott, Kansas, Forenede Stater, 66701
        • Cancer Center of Kansas - Fort Scott
      • Independence, Kansas, Forenede Stater, 67301
        • Cancer Center of Kansas-Independence
      • Kingman, Kansas, Forenede Stater, 67068
        • Cancer Center of Kansas, PA - Kingman
      • Lawrence, Kansas, Forenede Stater, 66044
        • Lawrence Memorial Hospital
      • Liberal, Kansas, Forenede Stater, 67901
        • Cancer Center of Kansas, PA - Liberal
      • McPherson, Kansas, Forenede Stater, 67460
        • Cancer Center of Kansas, PA - McPherson
      • Newton, Kansas, Forenede Stater, 67114
        • Cancer Center of Kansas, PA - Newton
      • Overland Park, Kansas, Forenede Stater, 66209
        • Menorah Medical Center
      • Overland Park, Kansas, Forenede Stater, 66213
        • Saint Luke's Hospital - South
      • Parsons, Kansas, Forenede Stater, 67357
        • Cancer Center of Kansas, PA - Parsons
      • Prairie Village, Kansas, Forenede Stater, 66208
        • CCOP - Kansas City
      • Pratt, Kansas, Forenede Stater, 67124
        • Cancer Center of Kansas, PA - Pratt
      • Salina, Kansas, Forenede Stater, 67401
        • Cancer Center of Kansas, PA - Salina
      • Topeka, Kansas, Forenede Stater, 66606
        • Cotton-O'Neil Cancer Center
      • Wellington, Kansas, Forenede Stater, 67152
        • Cancer Center of Kansas, PA - Wellington
      • Wichita, Kansas, Forenede Stater, 67208
        • Cancer Center of Kansas, PA - Medical Arts Tower
      • Wichita, Kansas, Forenede Stater, 67214
        • Cancer Center of Kansas, PA - Wichita
      • Wichita, Kansas, Forenede Stater, 67214
        • CCOP - Wichita
      • Wichita, Kansas, Forenede Stater, 67214
        • Via Christi Cancer Center at Via Christi Regional Medical Center
      • Wichita, Kansas, Forenede Stater, 67208
        • Associates in Womens Health, PA - North Review
      • Winfield, Kansas, Forenede Stater, 67156
        • Cancer Center of Kansas, PA - Winfield
    • Kentucky
      • Lexington, Kentucky, Forenede Stater, 40503-9985
        • Central Baptist Hospital
      • Louisville, Kentucky, Forenede Stater, 40202
        • Louisville Oncology at Norton Cancer Institute - Louisville
    • Louisiana
      • Alexandria, Louisiana, Forenede Stater, 71315-3198
        • Tulane Cancer Center Office of Clinical Research
      • Alexandria, Louisiana, Forenede Stater, 71301
        • CHRISTUS Cabrini Cancer Center
      • Baton Rouge, Louisiana, Forenede Stater, 70809
        • Mary Bird Perkins Cancer Center - Baton Rouge
      • Baton Rouge, Louisiana, Forenede Stater, 70809
        • Hematology-Oncology Clinic
      • Monroe, Louisiana, Forenede Stater, 71210
        • Louisiana State University Health Sciences Center - Monroe
      • New Orleans, Louisiana, Forenede Stater, 70121
        • CCOP - Ochsner
      • New Orleans, Louisiana, Forenede Stater, 70112
        • MBCCOP - LSU Health Sciences Center
      • New Orleans, Louisiana, Forenede Stater, 70121
        • Ochsner Cancer Institute at Ochsner Clinic Foundation
      • New Orleans, Louisiana, Forenede Stater, 70112
        • Medical Center of Louisiana - New Orleans
      • Shreveport, Louisiana, Forenede Stater, 71105
        • Highland Clinic
      • Shreveport, Louisiana, Forenede Stater, 71130-3932
        • Feist-Weiller Cancer Center at Louisiana State University Health Sciences
    • Maine
      • Augusta, Maine, Forenede Stater, 04330
        • Harold Alfond Center for Cancer Care
      • Bangor, Maine, Forenede Stater, 04401
        • CancerCare of Maine at Eastern Maine Medical Center
      • Portland, Maine, Forenede Stater, 04101
        • Mercy Hospital
    • Maryland
      • Baltimore, Maryland, Forenede Stater, 21237
        • Harry and Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center
      • Baltimore, Maryland, Forenede Stater, 21244
        • Kaiser Permanente at Woodlawn Medical Center
      • Easton, Maryland, Forenede Stater, 21601
        • Shore Regional Cancer Center at Memorial Hospital - Easton
      • Elkton, Maryland, Forenede Stater, 21921
        • Union Hospital of Cecil County
      • Frederick, Maryland, Forenede Stater, 21701
        • Frederick Memorial Hospital Regional Cancer Therapy Center
      • Gaithersburg, Maryland, Forenede Stater, 20879
        • Kaiser Permanente - Gaithersburg Medical Center
      • Largo, Maryland, Forenede Stater, 20774
        • Kaiser Permanente Mid-Atlantic Medical Group-Largo Medical Facility
      • Salisbury, Maryland, Forenede Stater, 21801
        • Peninsula Regional Medical Center
    • Massachusetts
      • Boston, Massachusetts, Forenede Stater, 02118
        • Boston University Cancer Research Center
      • Burlington, Massachusetts, Forenede Stater, 01805
        • Lahey Clinic Medical Center - Burlington
      • Fairhaven, Massachusetts, Forenede Stater, 02719
        • Southcoast Center for Cancer Care
      • Fall River, Massachusetts, Forenede Stater, 02721
        • Hudner Oncology Center at Saint Anne's Hospital - Fall River
      • Pittsfield, Massachusetts, Forenede Stater, 01201
        • Berkshire Hematology Oncology, PC
    • Michigan
      • Ann Arbor, Michigan, Forenede Stater, 48106-0995
        • Saint Joseph Mercy Cancer Center
      • Ann Arbor, Michigan, Forenede Stater, 48106
        • CCOP - Michigan Cancer Research Consortium
      • Battle Creek, Michigan, Forenede Stater, 49017
        • Battle Creek Health System Cancer Care Center
      • Big Rapids, Michigan, Forenede Stater, 49307
        • Mecosta County Medical Center
      • Dearborn, Michigan, Forenede Stater, 48123-2500
        • Oakwood Cancer Center at Oakwood Hospital and Medical Center
      • Detroit, Michigan, Forenede Stater, 48202
        • Josephine Ford Cancer Center at Henry Ford Hospital
      • Escanaba, Michigan, Forenede Stater, 49431
        • Green Bay Oncology, Limited - Escanaba
      • Flint, Michigan, Forenede Stater, 48503
        • Hurley Medical Center
      • Flint, Michigan, Forenede Stater, 48503
        • Genesys Hurley Cancer Institute
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Butterworth Hospital at Spectrum Health
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • CCOP - Grand Rapids
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Lacks Cancer Center at Saint Mary's Health Care
      • Grosse Pointe Woods, Michigan, Forenede Stater, 48236
        • Van Elslander Cancer Center at St. John Hospital and Medical Center
      • Iron Mountain, Michigan, Forenede Stater, 49801
        • Dickinson County Healthcare System
      • Jackson, Michigan, Forenede Stater, 49201
        • Foote Memorial Hospital
      • Kalamazoo, Michigan, Forenede Stater, 49007
        • Bronson Methodist Hospital
      • Kalamazoo, Michigan, Forenede Stater, 49001
        • Borgess Medical Center
      • Kalamazoo, Michigan, Forenede Stater, 49007-3731
        • West Michigan Cancer Center
      • Lansing, Michigan, Forenede Stater, 48912-1811
        • Sparrow Regional Cancer Center
      • Lansing, Michigan, Forenede Stater, 48910
        • Breslin Cancer Center at Ingham Regional Medical Center
      • Livonia, Michigan, Forenede Stater, 48154
        • St. Mary Mercy Hospital
      • Marquette, Michigan, Forenede Stater, 49855
        • Upper Michigan Cancer Center at Marquette General Hospital
      • Muskegon, Michigan, Forenede Stater, 49444
        • Mercy General Health Partners
      • Pontiac, Michigan, Forenede Stater, 48341-2985
        • St. Joseph Mercy Oakland
      • Port Huron, Michigan, Forenede Stater, 48060
        • Mercy Regional Cancer Center at Mercy Hospital
      • Reed City, Michigan, Forenede Stater, 49677
        • Spectrum Health Reed City Hospital
      • Royal Oak, Michigan, Forenede Stater, 48073
        • William Beaumont Hospital - Royal Oak Campus
      • Saginaw, Michigan, Forenede Stater, 48601
        • Seton Cancer Institute at Saint Mary's - Saginaw
      • Saint Joseph, Michigan, Forenede Stater, 49085
        • Lakeside Cancer Specialists, PLLC
      • Saint Joseph, Michigan, Forenede Stater, 49085
        • Lakeland Regional Cancer Care Center - St. Joseph
      • Traverse City, Michigan, Forenede Stater, 49684
        • Munson Medical Center
      • Warren, Michigan, Forenede Stater, 48093
        • St. John Macomb Hospital
    • Minnesota
      • Brainerd, Minnesota, Forenede Stater, 56401
        • St. Joseph's Medical Center
      • Burnsville, Minnesota, Forenede Stater, 55337
        • Fairview Ridges Hospital
      • Coon Rapids, Minnesota, Forenede Stater, 55433
        • Mercy and Unity Cancer Center at Mercy Hospital
      • Duluth, Minnesota, Forenede Stater, 55805
        • CCOP - Duluth
      • Duluth, Minnesota, Forenede Stater, 55805-1983
        • Duluth Clinic Cancer Center - Duluth
      • Duluth, Minnesota, Forenede Stater, 55805
        • Miller - Dwan Medical Center
      • Duluth, Minnesota, Forenede Stater, 55805
        • St. Luke's Hospital Cancer Care Center
      • Edina, Minnesota, Forenede Stater, 55435
        • Fairview Southdale Hospital
      • Fridley, Minnesota, Forenede Stater, 55432
        • Mercy and Unity Cancer Center at Unity Hospital
      • Hutchinson, Minnesota, Forenede Stater, 55350
        • Hutchinson Area Health Care
      • Mankato, Minnesota, Forenede Stater, 56002
        • Immanuel St. Joseph's
      • Maplewood, Minnesota, Forenede Stater, 55109
        • HealthEast Cancer Care at St. John's Hospital
      • Maplewood, Minnesota, Forenede Stater, 55109
        • Minnesota Oncology - Maplewood
      • Minneapolis, Minnesota, Forenede Stater, 55407
        • Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
      • Minneapolis, Minnesota, Forenede Stater, 55415
        • Hennepin County Medical Center - Minneapolis
      • New Ulm, Minnesota, Forenede Stater, 56073
        • New Ulm Medical Center
      • Robbinsdale, Minnesota, Forenede Stater, 55422-2900
        • Humphrey Cancer Center at North Memorial Outpatient Center
      • Rochester, Minnesota, Forenede Stater, 55905
        • Mayo Clinic Cancer Center
      • Saint Louis Park, Minnesota, Forenede Stater, 55416
        • CCOP - Metro-Minnesota
      • Saint Louis Park, Minnesota, Forenede Stater, 55416
        • Park Nicollet Cancer Center
      • Saint Paul, Minnesota, Forenede Stater, 55102
        • United Hospital
      • Saint Paul, Minnesota, Forenede Stater, 55101
        • Regions Hospital Cancer Care Center
      • Shakopee, Minnesota, Forenede Stater, 55379
        • St. Francis Cancer Center at St. Francis Medical Center
      • Stillwater, Minnesota, Forenede Stater, 55082
        • Lakeview Hospital
      • Waconia, Minnesota, Forenede Stater, 55387
        • Ridgeview Medical Center
      • Willmar, Minnesota, Forenede Stater, 56201
        • Willmar Cancer Center at Rice Memorial Hospital
      • Woodbury, Minnesota, Forenede Stater, 55125
        • Minnesota Oncology - Woodbury
    • Missouri
      • Bolivar, Missouri, Forenede Stater, 65613
        • Central Care Cancer Center at Carrie J. Babb Cancer Center
      • Cape Girardeau, Missouri, Forenede Stater, 63703
        • Southeast Cancer Center
      • Chesterfield, Missouri, Forenede Stater, 63017
        • Saint Luke's Hospital
      • Jefferson City, Missouri, Forenede Stater, 65109
        • Goldschmidt Cancer Center
      • Kansas City, Missouri, Forenede Stater, 64116
        • North Kansas City Hospital
      • Kansas City, Missouri, Forenede Stater, 64132
        • Research Medical Center
      • Kansas City, Missouri, Forenede Stater, 64111
        • Saint Luke's Cancer Institute at Saint Luke's Hospital
      • Kansas City, Missouri, Forenede Stater, 64118
        • Heartland Hematology Oncology Associates, Incorporated
      • Lee's Summit, Missouri, Forenede Stater, 64086
        • Saint Luke's East - Lee's Summit
      • Liberty, Missouri, Forenede Stater, 64068
        • Parvin Radiation Oncology
      • Rolla, Missouri, Forenede Stater, 65401
        • Phelps County Regional Medical Center
      • Saint Joseph, Missouri, Forenede Stater, 64506
        • Heartland Regional Medical Center
      • Saint Joseph, Missouri, Forenede Stater, 64507
        • Saint Joseph Oncology, Incorporated
      • Saint Louis, Missouri, Forenede Stater, 63131
        • Missouri Baptist Cancer Center
      • Saint Louis, Missouri, Forenede Stater, 63110
        • Saint Louis University Cancer Center
      • Springfield, Missouri, Forenede Stater, 65802
        • CCOP - Cancer Research for the Ozarks
      • Springfield, Missouri, Forenede Stater, 65804
        • St. John's Regional Health Center
      • Springfield, Missouri, Forenede Stater, 65807
        • Hulston Cancer Center at Cox Medical Center South
    • Montana
      • Billings, Montana, Forenede Stater, 59101
        • CCOP - Montana Cancer Consortium
      • Billings, Montana, Forenede Stater, 59101
        • St. Vincent Healthcare Cancer Care Services
      • Billings, Montana, Forenede Stater, 59107-7000
        • Billings Clinic - Downtown
      • Billings, Montana, Forenede Stater, 59102
        • Hematology-Oncology Centers of the Northern Rockies - Billings
      • Bozeman, Montana, Forenede Stater, 59715
        • Bozeman Deaconess Cancer Center
      • Butte, Montana, Forenede Stater, 59701
        • St. James Healthcare Cancer Care
      • Great Falls, Montana, Forenede Stater, 59405
        • Great Falls Clinic - Main Facility
      • Great Falls, Montana, Forenede Stater, 59405-5309
        • Big Sky Oncology
      • Great Falls, Montana, Forenede Stater, 59405
        • Sletten Cancer Institute at Benefis Healthcare
      • Helena, Montana, Forenede Stater, 59601
        • St. Peter's Hospital
      • Kalispell, Montana, Forenede Stater, 59901
        • Kalispell Regional Medical Center
      • Kalispell, Montana, Forenede Stater, 59901
        • Glacier Oncology, PLLC
      • Kalispell, Montana, Forenede Stater, 59901
        • Kalispell Medical Oncology at KRMC
      • Missoula, Montana, Forenede Stater, 59807-7877
        • Montana Cancer Specialists at Montana Cancer Center
      • Missoula, Montana, Forenede Stater, 59807
        • Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
    • Nebraska
      • Lincoln, Nebraska, Forenede Stater, 68510
        • Cancer Resource Center - Lincoln
      • Omaha, Nebraska, Forenede Stater, 68106
        • CCOP - Missouri Valley Cancer Consortium
      • Omaha, Nebraska, Forenede Stater, 68122
        • Immanuel Medical Center
      • Omaha, Nebraska, Forenede Stater, 68124
        • Alegant Health Cancer Center at Bergan Mercy Medical Center
      • Omaha, Nebraska, Forenede Stater, 68131-2197
        • Creighton University Medical Center
      • Omaha, Nebraska, Forenede Stater, 68114
        • Methodist Estabrook Cancer Center
      • Omaha, Nebraska, Forenede Stater, 68130
        • Lakeside Hospital
    • Nevada
      • Las Vegas, Nevada, Forenede Stater, 89102
        • University Medical Center of Southern Nevada
      • Las Vegas, Nevada, Forenede Stater, 89106
        • CCOP - Nevada Cancer Research Foundation
    • New Hampshire
      • Concord, New Hampshire, Forenede Stater, 03301
        • New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care
      • Exeter, New Hampshire, Forenede Stater, 03833
        • Center for Cancer Care at Exeter Hospital
      • Hooksett, New Hampshire, Forenede Stater, 03106
        • New Hampshire Oncology - Hematology, PA - Hooksett
      • Laconia, New Hampshire, Forenede Stater, 03246
        • Lakes Region General Hospital
    • New Jersey
      • Flemington, New Jersey, Forenede Stater, 08822
        • Hunterdon Regional Cancer Center at Hunterdon Medical Center
      • Hackensack, New Jersey, Forenede Stater, 07601
        • CCOP - Northern New Jersey
      • Livingston, New Jersey, Forenede Stater, 07039
        • St. Barnabas Medical Center Cancer Center
      • Long Branch, New Jersey, Forenede Stater, 07740-6395
        • Monmouth Medical Center
      • Marlton, New Jersey, Forenede Stater, 08053
        • Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
      • Newark, New Jersey, Forenede Stater, 07112
        • Newark Beth Israel Medical Center
      • Pennington, New Jersey, Forenede Stater, 08534
        • Capital Health Regional Cancer Center
      • Somerville, New Jersey, Forenede Stater, 08876
        • Somerset Medical Center
      • Sparta, New Jersey, Forenede Stater, 07871
        • Frederick R. and Betty M. Smith Cancer Treatment Center
      • Toms River, New Jersey, Forenede Stater, 08755
        • J. Phillip Citta Regional Cancer Center at Community Medical Center
      • Vineland, New Jersey, Forenede Stater, 08360
        • Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare
      • Voorhees, New Jersey, Forenede Stater, 08043
        • Cancer Institute of New Jersey at Cooper - Voorhees
      • Voorhees, New Jersey, Forenede Stater, 08043
        • Fox Chase Virtua Health Cancer Program at Virtua West Jersey
    • New Mexico
      • Albuquerque, New Mexico, Forenede Stater, 87131-5636
        • University of New Mexico Cancer Center
      • Albuquerque, New Mexico, Forenede Stater, 87106
        • Hematology Oncology Associates, PC
      • Albuquerque, New Mexico, Forenede Stater, 87102
        • Lovelace Medical Center - Downtown
    • New York
      • Buffalo, New York, Forenede Stater, 14215
        • Veterans Affairs Medical Center - Buffalo
      • East Syracuse, New York, Forenede Stater, 13057
        • CCOP - Hematology-Oncology Associates of Central New York
      • Elmhurst, New York, Forenede Stater, 11373
        • Elmhurst Hospital Center
      • Jamaica, New York, Forenede Stater, 11432
        • Queens Cancer Center of Queens Hospital
      • Lake Success, New York, Forenede Stater, 11042
        • Monter Cancer Center of the North Shore-LIJ Health System
      • Manhasset, New York, Forenede Stater, 11030
        • CCOP - North Shore University Hospital
      • Manhasset, New York, Forenede Stater, 11030
        • Don Monti Comprehensive Cancer Center at North Shore University Hospital
      • Middletown, New York, Forenede Stater, 10940-4199
        • Tucker Center for Cancer Care at Orange Regional Medical Center
      • New Hyde Park, New York, Forenede Stater, 11040
        • Long Island Jewish Medical Center
      • Staten Island, New York, Forenede Stater, 10305
        • Nalitt Cancer Institute at Staten Island University Hospital
      • Syracuse, New York, Forenede Stater, 13210
        • SUNY Upstate Medical University Hospital
    • North Carolina
      • Asheboro, North Carolina, Forenede Stater, 27203-5400
        • Randolph Hospital
      • Asheville, North Carolina, Forenede Stater, 28801
        • Mission Hospitals - Memorial Campus
      • Burlington, North Carolina, Forenede Stater, 27216
        • Alamance Cancer Center at Alamance Regional Medical Center
      • Charlotte, North Carolina, Forenede Stater, 28232-2861
        • Blumenthal Cancer Center at Carolinas Medical Center
      • Goldsboro, North Carolina, Forenede Stater, 27534
        • Wayne Memorial Hospital, Incorporated
      • Greensboro, North Carolina, Forenede Stater, 27403-1198
        • Moses Cone Regional Cancer Center at Wesley Long Community Hospital
      • Hendersonville, North Carolina, Forenede Stater, 28791
        • Pardee Memorial Hospital
      • Kinston, North Carolina, Forenede Stater, 28501
        • Kinston Medical Specialists
      • Pinehurst, North Carolina, Forenede Stater, 28374
        • FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center
      • Reidsville, North Carolina, Forenede Stater, 27320
        • Annie Penn Cancer Center
      • Rutherfordton, North Carolina, Forenede Stater, 28139
        • Rutherford Hospital
      • Statesville, North Carolina, Forenede Stater, 28677
        • Iredell Memorial Hospital
      • Winston-Salem, North Carolina, Forenede Stater, 27103
        • Forsyth Regional Cancer Center at Forsyth Medical Center
    • North Dakota
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Medcenter One Hospital Cancer Care Center
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Mid Dakota Clinic, PC
      • Bismarck, North Dakota, Forenede Stater, 58502
        • St. Alexius Medical Center Cancer Center
      • Fargo, North Dakota, Forenede Stater, 58103
        • Dakota Cancer Institute at Dakota Clinic - South University
      • Grand Forks, North Dakota, Forenede Stater, 58201
        • Altru Cancer Center at Altru Hospital
      • Minot, North Dakota, Forenede Stater, 58701
        • Trinity CancerCare Center
    • Ohio
      • Akron, Ohio, Forenede Stater, 44307
        • McDowell Cancer Center at Akron General Medical Center
      • Akron, Ohio, Forenede Stater, 44309-2090
        • Summa Center for Cancer Care at Akron City Hospital
      • Canton, Ohio, Forenede Stater, 44710-1799
        • Aultman Cancer Center at Aultman Hospital
      • Canton, Ohio, Forenede Stater, 44708
        • Mercy Cancer Center at Mercy Medical Center
      • Chillicothe, Ohio, Forenede Stater, 45601
        • Adena Regional Medical Center
      • Cincinnati, Ohio, Forenede Stater, 45267
        • Charles M. Barrett Cancer Center at University Hospital
      • Cincinnati, Ohio, Forenede Stater, 45219
        • Christ Hospital Cancer Center
      • Columbus, Ohio, Forenede Stater, 43214-3998
        • Riverside Methodist Hospital Cancer Care
      • Columbus, Ohio, Forenede Stater, 43222
        • Mount Carmel Health - West Hospital
      • Columbus, Ohio, Forenede Stater, 43215
        • CCOP - Columbus
      • Columbus, Ohio, Forenede Stater, 43215
        • Grant Medical Center Cancer Care
      • Columbus, Ohio, Forenede Stater, 43228
        • Doctors Hospital at Ohio Health
      • Dayton, Ohio, Forenede Stater, 45405
        • Grandview Hospital
      • Dayton, Ohio, Forenede Stater, 45406
        • Good Samaritan Hospital
      • Dayton, Ohio, Forenede Stater, 45409
        • David L. Rike Cancer Center at Miami Valley Hospital
      • Dayton, Ohio, Forenede Stater, 45415
        • Samaritan North Cancer Care Center
      • Dayton, Ohio, Forenede Stater, 45420
        • CCOP - Dayton
      • Delaware, Ohio, Forenede Stater, 43015
        • Grady Memorial Hospital
      • Findlay, Ohio, Forenede Stater, 45840
        • Blanchard Valley Medical Associates
      • Franklin, Ohio, Forenede Stater, 45005-1066
        • Middletown Regional Hospital
      • Greenville, Ohio, Forenede Stater, 45331
        • Wayne Hospital
      • Kettering, Ohio, Forenede Stater, 45429
        • Charles F. Kettering Memorial Hospital
      • Lancaster, Ohio, Forenede Stater, 43130
        • Fairfield Medical Center
      • Lima, Ohio, Forenede Stater, 45801
        • St. Rita's Medical Center
      • Marietta, Ohio, Forenede Stater, 45750
        • Strecker Cancer Center at Marietta Memorial Hospital
      • Mount Vernon, Ohio, Forenede Stater, 43050
        • Knox Community Hospital
      • Newark, Ohio, Forenede Stater, 43055
        • Licking Memorial Cancer Care Program at Licking Memorial Hospital
      • Springfield, Ohio, Forenede Stater, 45505
        • Community Hospital of Springfield and Clark County
      • Troy, Ohio, Forenede Stater, 45373-1300
        • UVMC Cancer Care Center at Upper Valley Medical Center
      • Westerville, Ohio, Forenede Stater, 43081
        • Mount Carmel St. Ann's Cancer Center
      • Wright-Patterson Air Force Base, Ohio, Forenede Stater, 45433-5529
        • United States Air Force Medical Center - Wright-Patterson
      • Xenia, Ohio, Forenede Stater, 45385
        • Ruth G. McMillan Cancer Center at Greene Memorial Hospital
      • Zanesville, Ohio, Forenede Stater, 43701
        • Genesis - Good Samaritan Hospital
    • Oklahoma
      • Norman, Oklahoma, Forenede Stater, 73071
        • Cancer Care Associates - Norman
      • Oklahoma City, Oklahoma, Forenede Stater, 73120
        • Cancer Care Associates - Mercy Campus
      • Tulsa, Oklahoma, Forenede Stater, 74136
        • Natalie Warren Bryant Cancer Center at St. Francis Hospital
    • Oregon
      • Clackamas, Oregon, Forenede Stater, 97015
        • Clackamas Radiation Oncology Center
      • Milwaukie, Oregon, Forenede Stater, 97222
        • Providence Milwaukie Hospital
      • Newberg, Oregon, Forenede Stater, 97132
        • Providence Newberg Medical Center
      • Oregon City, Oregon, Forenede Stater, 97045
        • Willamette Falls Hospital
      • Portland, Oregon, Forenede Stater, 97213-2967
        • Providence Cancer Center at Providence Portland Medical Center
      • Portland, Oregon, Forenede Stater, 97225
        • CCOP - Columbia River Oncology Program
      • Portland, Oregon, Forenede Stater, 97225
        • Providence St. Vincent Medical Center
      • Portland, Oregon, Forenede Stater, 97227
        • Kaiser Permanente Health Care - Portland
      • Salem, Oregon, Forenede Stater, 97309-5014
        • Salem Hospital Regional Cancer Care Services
      • The Dalles, Oregon, Forenede Stater, 97058
        • Celilo Cancer Center at Mid-Columbia Medical Center
    • Pennsylvania
      • Abington, Pennsylvania, Forenede Stater, 19001
        • Rosenfeld Cancer Center at Abington Memorial Hospital
      • Allentown, Pennsylvania, Forenede Stater, 18105
        • Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
      • Bethlehem, Pennsylvania, Forenede Stater, 18017
        • Lehigh Valley Hospital - Muhlenberg
      • Danville, Pennsylvania, Forenede Stater, 17822-0001
        • Geisinger Cancer Institute at Geisinger Health
      • Darby, Pennsylvania, Forenede Stater, 19023
        • Mercy Fitzgerald Hospital
      • Doylestown, Pennsylvania, Forenede Stater, 18901
        • Doylestown Hospital Cancer Center
      • Drexel Hill, Pennsylvania, Forenede Stater, 19026
        • Delaware County Regional Cancer Center at Delaware County Memorial Hospital
      • DuBois, Pennsylvania, Forenede Stater, 15801
        • Oncology Hematology Associates of Northern Pennsylvania, PC at Hahne Regional Cancer Center
      • East Stroudsburg, Pennsylvania, Forenede Stater, 18301
        • Dale and Frances Hughes Cancer Center at Pocono Medical Center
      • Ephrata, Pennsylvania, Forenede Stater, 17522
        • Ephrata Cancer Center at Ephrata Community Hospital
      • Gettysburg, Pennsylvania, Forenede Stater, 17325
        • Adams Cancer Center
      • Hanover, Pennsylvania, Forenede Stater, 17331
        • Cherry Tree Cancer Center
      • Harrisburg, Pennsylvania, Forenede Stater, 17110-2098
        • PinnacleHealth Regional Cancer Center at Polyclinic Hospital
      • Hazleton, Pennsylvania, Forenede Stater, 18201
        • Geisinger Hazleton Cancer Center
      • Media, Pennsylvania, Forenede Stater, 19063
        • Riddle Memorial Hospital Cancer Center
      • Monroeville, Pennsylvania, Forenede Stater, 15146
        • Forbes Regional Hospital
      • Philadelphia, Pennsylvania, Forenede Stater, 19107-5541
        • Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
      • Pittsburgh, Pennsylvania, Forenede Stater, 15212
        • Allegheny Cancer Center at Allegheny General Hospital
      • Pittsburgh, Pennsylvania, Forenede Stater, 15224-1791
        • Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital
      • Pottstown, Pennsylvania, Forenede Stater, 19464
        • Pottstown Memorial Regional Cancer Center
      • Scranton, Pennsylvania, Forenede Stater, 18501
        • Mercy Hospital Cancer Center - Scranton
      • Scranton, Pennsylvania, Forenede Stater, 18510
        • Hematology and Oncology Associates of Northeastern Pennsylvania
      • State College, Pennsylvania, Forenede Stater, 16801
        • Geisinger Medical Group - Scenery Park
      • Upland, Pennsylvania, Forenede Stater, 19013
        • Associates in Hematology-Oncology, PC at Crozer Regional Cancer Center
      • West Grove, Pennsylvania, Forenede Stater, 19390-9499
        • Jennersville Regional Hospital
      • Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
        • Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
      • Williamsport, Pennsylvania, Forenede Stater, 17701
        • Susquehanna Cancer Center at Divine Providence Hospital
      • York, Pennsylvania, Forenede Stater, 17405
        • York Cancer Center at Apple Hill Medical Center
    • South Carolina
      • Anderson, South Carolina, Forenede Stater, 29621
        • AnMed Cancer Center
      • Charleston, South Carolina, Forenede Stater, 29425
        • Hollings Cancer Center at Medical University of South Carolina
      • Charleston, South Carolina, Forenede Stater, 29401
        • Roper St. Francis Cancer Center at Roper Hospital
      • Florence, South Carolina, Forenede Stater, 29501
        • McLeod Regional Medical Center
      • Greenville, South Carolina, Forenede Stater, 29615
        • CCOP - Greenville
      • Greenville, South Carolina, Forenede Stater, 29605
        • Greenville Hospital Cancer Center
      • Greenville, South Carolina, Forenede Stater, 29605
        • Cancer Centers of the Carolinas - Faris Road
      • Greenville, South Carolina, Forenede Stater, 29605
        • Cancer Centers of the Carolinas - Grove Commons
      • Greenville, South Carolina, Forenede Stater, 29601
        • Bon Secours St. Francis Health System
      • Greer, South Carolina, Forenede Stater, 29650
        • Cancer Centers of the Carolinas - Greer Medical Oncology
      • Seneca, South Carolina, Forenede Stater, 29672
        • Cancer Centers of the Carolinas - Seneca
      • Spartanburg, South Carolina, Forenede Stater, 29303
        • CCOP - Upstate Carolina
      • Spartanburg, South Carolina, Forenede Stater, 29303
        • Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
      • Spartanburg, South Carolina, Forenede Stater, 29307
        • Cancer Centers of the Carolinas - Spartanburg
    • South Dakota
      • Aberdeen, South Dakota, Forenede Stater, 57401
        • Oncology Services of Aberdeen
      • Rapid City, South Dakota, Forenede Stater, 57701
        • Rapid City Regional Hospital
      • Sioux Falls, South Dakota, Forenede Stater, 57105
        • Avera Cancer Institute
      • Sioux Falls, South Dakota, Forenede Stater, 57117-5039
        • Sanford Cancer Center at Sanford USD Medical Center
    • Tennessee
      • Kingsport, Tennessee, Forenede Stater, 37662
        • Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center
      • Knoxville, Tennessee, Forenede Stater, 37916
        • Thompson Cancer Survival Center
    • Texas
      • Houston, Texas, Forenede Stater, 77030-4009
        • M. D. Anderson Cancer Center at University of Texas
      • Laredo, Texas, Forenede Stater, 78045
        • Doctor's Hospital of Laredo
      • Lubbock, Texas, Forenede Stater, 79410-1894
        • Joe Arrington Cancer Research and Treatment Center
      • San Antonio, Texas, Forenede Stater, 78229-3900
        • University of Texas Health Science Center at San Antonio
    • Utah
      • American Fork, Utah, Forenede Stater, 84003
        • American Fork Hospital
      • Cedar City, Utah, Forenede Stater, 84720
        • Sandra L. Maxwell Cancer Center
      • Logan, Utah, Forenede Stater, 84321
        • Logan Regional Hospital
      • Murray, Utah, Forenede Stater, 84157
        • Jon and Karen Huntsman Cancer Center at Intermountain Medical Center
      • Ogden, Utah, Forenede Stater, 84403
        • Val and Ann Browning Cancer Center at McKay-Dee Hospital Center
      • Provo, Utah, Forenede Stater, 84604
        • Utah Valley Regional Medical Center - Provo
      • Saint George, Utah, Forenede Stater, 84770
        • Dixie Regional Medical Center - East Campus
      • Salt Lake City, Utah, Forenede Stater, 84143
        • LDS Hospital
      • Salt Lake City, Utah, Forenede Stater, 84106
        • Utah Cancer Specialists at UCS Cancer Center
    • Virginia
      • Fairfax, Virginia, Forenede Stater, 22033
        • Kaiser Permanente Medical Center - Fair Oaks
      • McLean, Virginia, Forenede Stater, 22102
        • Kaiser Permanente Tysons Corner Medical Center
      • Norton, Virginia, Forenede Stater, 24273
        • Southwest Virginia Regional Cancer Center at Wellmonth Health
      • Richmond, Virginia, Forenede Stater, 23298-0037
        • Virginia Commonwealth University Massey Cancer Center
    • Washington
      • Bellevue, Washington, Forenede Stater, 98004
        • Overlake Cancer Center at Overlake Hospital Medical Center
      • Bellingham, Washington, Forenede Stater, 98225
        • St. Joseph Cancer Center
      • Bremerton, Washington, Forenede Stater, 98310
        • Olympic Hematology and Oncology
      • Centralia, Washington, Forenede Stater, 98531-9027
        • Providence Centralia Hospital
      • Everett, Washington, Forenede Stater, 98201
        • Providence Regional Cancer Partnership
      • Federal Way, Washington, Forenede Stater, 98003
        • St. Francis Hospital
      • Mount Vernon, Washington, Forenede Stater, 98274
        • Skagit Valley Hospital Cancer Care Center
      • Olympia, Washington, Forenede Stater, 98506-5166
        • Providence St. Peter Hospital Regional Cancer Center
      • Puyallup, Washington, Forenede Stater, 98372
        • Good Samaritan Cancer Center
      • Seattle, Washington, Forenede Stater, 98109
        • Fred Hutchinson Cancer Research Center
      • Seattle, Washington, Forenede Stater, 98112
        • Group Health Central Hospital
      • Seattle, Washington, Forenede Stater, 98122-4307
        • Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
      • Sequim, Washington, Forenede Stater, 98382
        • Olympic Medical Cancer Center
      • Spokane, Washington, Forenede Stater, 99204-2967
        • Rockwood Clinic Cancer Treatment Center
      • Tacoma, Washington, Forenede Stater, 98405-3004
        • Franciscan Cancer Center at St. Joseph Medical Center
      • Tacoma, Washington, Forenede Stater, 98405
        • Allenmore Hospital
      • Tacoma, Washington, Forenede Stater, 98405
        • CCOP - Northwest
      • Tacoma, Washington, Forenede Stater, 98405
        • MultiCare Regional Cancer Center at Tacoma General Hospital
      • Tacoma, Washington, Forenede Stater, 98499
        • St. Clare Hospital
      • Vancouver, Washington, Forenede Stater, 98664
        • Southwest Washington Medical Center Cancer Center
      • Walla Walla, Washington, Forenede Stater, 99362
        • St. Mary Regional Cancer Center at St. Mary Medical Center
      • Wenatchee, Washington, Forenede Stater, 98801-2028
        • Wenatchee Valley Medical Center
    • West Virginia
      • Clarksburg, West Virginia, Forenede Stater, 26301
        • United Hospital Center
      • Huntington, West Virginia, Forenede Stater, 25702
        • St. Mary's Regional Cancer Center at St. Mary's Medical Center
      • Princeton, West Virginia, Forenede Stater, 24740
        • Princeton Community Hospital
    • Wisconsin
      • Antigo, Wisconsin, Forenede Stater, 54409
        • Langlade Memorial Hospital
      • Green Bay, Wisconsin, Forenede Stater, 54301
        • Bellin Memorial Hospital
      • Green Bay, Wisconsin, Forenede Stater, 54307-3508
        • St. Vincent Hospital Regional Cancer Center
      • Green Bay, Wisconsin, Forenede Stater, 54301-3526
        • Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
      • Green Bay, Wisconsin, Forenede Stater, 54303
        • Green Bay Oncology, Limited at St. Mary's Hospital
      • Green Bay, Wisconsin, Forenede Stater, 54303
        • St. Mary's Hospital Medical Center - Green Bay
      • Janesville, Wisconsin, Forenede Stater, 53547
        • Mercy Regional Cancer Center
      • Madison, Wisconsin, Forenede Stater, 53717
        • Dean Medical Center - Madison
      • Manitowoc, Wisconsin, Forenede Stater, 54221-1450
        • Holy Family Memorial Medical Center Cancer Care Center
      • Marinette, Wisconsin, Forenede Stater, 54143
        • Bay Area Cancer Care Center at Bay Area Medical Center
      • Marshfield, Wisconsin, Forenede Stater, 54449
        • Marshfield Clinic - Marshfield Center
      • Mukwonago, Wisconsin, Forenede Stater, 53149
        • D.N. Greenwald Center
      • Oconomowoc, Wisconsin, Forenede Stater, 53066
        • Regional Cancer Center at Oconomowoc Memorial Hospital
      • Oconto Falls, Wisconsin, Forenede Stater, 54154
        • Green Bay Oncology, Limited - Oconto Falls
      • Rice Lake, Wisconsin, Forenede Stater, 54868
        • Marshfield Clinic - Indianhead Center
      • Sheboygan, Wisconsin, Forenede Stater, 53081
        • St. Nicholas Hospital
      • Sturgeon Bay, Wisconsin, Forenede Stater, 54235
        • Green Bay Oncology, Limited - Sturgeon Bay
      • Waukesha, Wisconsin, Forenede Stater, 53188
        • Waukesha Memorial Hospital Regional Cancer Center
      • Wausau, Wisconsin, Forenede Stater, 54401
        • University of Wisconcin Cancer Center at Aspirus Wausau Hospital
      • Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
        • Riverview UW Cancer Center at Riverview Hospital
    • Wyoming
      • Casper, Wyoming, Forenede Stater, 82609
        • Rocky Mountain Oncology

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Beskrivelse

Inklusionskriterier

  • Patienter skal have en Eastern Cooperative Oncology Group (ECOG) præstationsstatus på 0 eller 1.
  • Patienter skal have evnen til at sluge oral medicin.
  • Patienter skal have resekeret adenokarcinom i tyktarmen iscenesat som American Joint Committee on Cancer (AJCC) Stage 0, I, II eller III.
  • Patienterne skal have fået foretaget kirurgisk resektion af colon-adenokarcinomet med helbredende hensigt inden for 1 år før randomisering. (Laparoskopisk assisteret kolektomi er tilladt.)
  • Patienter skal have afsluttet enhver adjuverende behandling før randomisering.
  • Patienter, der tager kardiobeskyttende lavdosis aspirin ved start af undersøgelsen, må ikke have klinisk signifikant toksicitet, som bestemt af investigator, der udelukker fortsættelse af aspirin, og patienten skal være villig til at fortsætte aspirinbehandling (81 mg eller 325 mg) under hele undersøgelsen terapi.
  • Koloskopikrav inden for 180 dage før randomisering:
  • Patienten skal enten have gennemgået en præoperativ eller postoperativ dokumenteret koloskopi til blindtarmen (eller tyndtarmsanastomose) med tilstrækkelig tarmforberedelse.
  • Alle observerede polypper skal være fjernet. (Polypper kan fjernes under koloskopi eller kirurgi udført før randomisering.)
  • Postoperativ serumkreatinin udført inden for 90 dage før randomisering skal være mindre end eller lig med 1,5 x øvre normalgrænse (ULN) for laboratoriet.
  • Følgende kriterier for bevis for tilstrækkelig leverfunktion baseret på postoperativ test udført inden for 90 dage før randomisering skal være opfyldt: aspartataminotransferase (AST) eller alaninaminotransferase (ALT) mindre end eller lig med 3,0 x ULN for laboratoriet, og total bilirubin mindre end eller lig med 1,5 x ULN for laboratoriet

Eksklusionskriterier

  • Tumor med den distale kant placeret mindre end 12 cm fra analkanten.
  • Total kolektomi eller total proktokolektomi.
  • Klassisk familiær adenomatøs polypose, svækket familiær adenomatøs polypose (dvs. 20 eller flere adenomer, enten synkrone eller metakrone), eller arvelig nonpolypose kolorektal cancer (Lynch-syndrom).
  • Malabsorptionssyndrom, colitis ulcerosa, inflammatorisk tarmsygdom, resektion af mave eller tyndtarm eller anden sygdom, der signifikant påvirker mave-tarmfunktionen.
  • Anamnese med dokumenteret øvre GI-blødning eller øvre GI-ulcerøs sygdom.
  • Statinbrug inden for 30 dage før randomisering.
  • Hyperlipidæmi med klinisk indikation for statinbehandling eller anden ordineret medicin. Bestemmelse af acceptable fastende lipidværdier inden for 90 dage før randomisering bør være i overensstemmelse med gældende retningslinjer for dyslipidæmihåndtering.
  • Uvilje til at afbryde kronisk brug af ikke-steroide antiinflammatoriske lægemidler (NSAID'er) (bortset fra hjertebeskyttende lavdosis aspirin 81 mg eller 325 mg) før randomisering.
  • Forventet behov for kronisk brug af NSAID'er (andre end hjertebeskyttende lavdosis aspirin 81 mg eller 325 mg).
  • Utilstrækkeligt behandlet hypothyroidisme, som bestemt af investigator.
  • Anamnese med myopati eller rabdomyolyse.
  • Overfølsomhed eller intolerance over for statiner.
  • Kronisk lægemiddelbehandling med cyclosporin, coumarin antikoagulantia, gemfibrozil, nogle andre lipidsænkende behandlinger (fibrater eller niacin), lopinavir/ritonavir eller lægemidler (såsom ketoconazol, spironolacton eller cimetidin), der sænker niveauet eller aktiviteten af ​​steroidhormoner.
  • Graviditet eller amning på tidspunktet for studiestart. (Graviditetstest skal udføres inden for 14 dage før randomisering i henhold til institutionelle standarder for kvinder i den fødedygtige alder.)
  • Tidligere maligniteter, medmindre patienten har været sygdomsfri i 5 eller flere år før randomisering og af lægen vurderes at have lav risiko for tilbagefald. Patienter med følgende kræftformer er berettigede, hvis de er diagnosticeret og behandlet inden for de seneste 5 år: alle in situ kræftformer og basalcelle- og pladecellekarcinom i huden.
  • Anden ikke-malign systemisk sygdom, som ville udelukke en patient fra at få rosuvastatin eller ville forhindre forlænget opfølgning.
  • Administration af ethvert forsøgsmiddel inden for 30 dage før randomisering.

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Behandling
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Firedobbelt

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Placebo komparator: Gruppe 1: placebo
Patienterne får oral placebo én gang dagligt i 5 år.
Andet: placebo
Eksperimentel: Gruppe 2: rosuvastatin
Patienter får oralt rosuvastatin én gang dagligt i 5 år.
Medicin: rosuvastatin
Andre navne:
  • Crestor

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Forekomst af ≥ 1 adenomatøs polyp i tyktarmen eller endetarmen, metakront kolorektalt karcinom eller recidiv af tyktarmskræft (APMC+R)
Tidsramme: Op til 4,8 år
Procentdel af patienter med forekomst af APMC+R-hændelse. APMC+R-hændelser omfatter mindst én adenomatøs polyp i tyktarmen eller endetarmen, metakront kolorektalt karcinom eller recidiv af tyktarmskræft
Op til 4,8 år

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Størrelse af kolorektale adenomer, inklusive avancerede adenomer
Tidsramme: Op til 4,8 år
Den histologiske størrelse (diameter af adenom ind i tyktarmens væg; i henhold til AJCC-stadieinddeling) af det største adenom blandt patienter, som har mindst ét ​​adenom påvist. Hvis histologisk størrelse ikke var tilgængelig, blev den endoskopiske størrelse angivet.
Op til 4,8 år
Sygdomsfri overlevelse
Tidsramme: Op til 4,8 år
Antal patienter med DFS-hændelse (tilbagefald af tyktarmskræft, anden primær cancer eller død af enhver årsag)
Op til 4,8 år
Samlet overlevelse (OS)
Tidsramme: Op til 4,8 år
Antal patienter med OS-hændelsen (død uanset årsag)
Op til 4,8 år
Gentagelsesfrit interval (RFI)
Tidsramme: Op til 4,8 år
Antal patienter med RFI-hændelsen (første recidiv af tyktarmskræft)
Op til 4,8 år
Andet ikke-kolorektalt primært kræftfrit interval
Tidsramme: Op til 4,8 år
Antal patienter med den første forekomst af ikke-kolorektal primær cancer
Op til 4,8 år
Adfærds- og sundhedsresultater målt ved SF-12-komponentscore, global livskvalitetsskala og symptomtjekliste
Tidsramme: 12-måneders tidspunkt
Global Quality-of-Life Scale score, spænder fra 0 (værst tænkelige sundhedstilstand) til 10 (bedst tænkelige sundhedstilstand.
12-måneders tidspunkt
Toksicitet vurderet ved uønskede hændelser
Tidsramme: Op til 4,8 år
Procentdel af patienter med mindst én grad 2 eller højere bivirkning rapporteret.
Op til 4,8 år
Målinger af relevante tumor- og blodmarkører
Tidsramme: Ved randomisering
Denne undersøgelse blev afsluttet tidligt. Data om prøver blev ikke indsamlet, de relevante analyser blev ikke udført.
Ved randomisering

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

NSABP Foundation Inc

Samarbejdspartnere

National Cancer Institute (NCI)

Efterforskere

  • Ledende efterforsker: Norman Wolmark, MD, NSABP Foundation Inc

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

  • Boman BM, Bandos H, Wickerham DL, et al.: Statin polyp prevention trial in patients with resected colon cancer: NSABP protocol P-5. [Abstract] J Clin Oncol 30 (Suppl 15): A-TPS1615, 2012.

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart

1. marts 2010

Primær færdiggørelse (Faktiske)

1. december 2014

Studieafslutning (Faktiske)

1. februar 2015

Datoer for studieregistrering

Først indsendt

10. november 2009

Først indsendt, der opfyldte QC-kriterier

10. november 2009

Først opslået (Anslået)

11. november 2009

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

16. august 2023

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

27. juli 2023

Sidst verificeret

1. juli 2023

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • NSABP-P-5
  • NSABP P-5
  • NCI-2011-09183 (Registry Identifier: CTRP (Clinical Trials Reporting Program))

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Abonner