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Rosuvastatin i behandling av pasienter med stadium I eller stadium II tykktarmskreft som ble fjernet ved kirurgi

27. juli 2023 oppdatert av: NSABP Foundation Inc

Statinpolyppforebyggingsforsøk hos pasienter med reseksjonert tykktarmskreft

RASIONALE: Rosuvastatin kan stoppe veksten av tumorceller ved å blokkere noen av enzymene som trengs for cellevekst. Å gi rosuvastatin etter operasjonen kan drepe eventuelle tumorceller som er igjen etter operasjonen. Det kan også forhindre at polypper dannes eller tykktarmskreft kommer tilbake. Det er ennå ikke kjent om rosuvastatin er mer effektivt enn placebo ved behandling av tykktarmskreft som ble fjernet ved kirurgi.

FORMÅL: Denne randomiserte fase III-studien studerer rosuvastatin for å se hvor godt det virker sammenlignet med placebo ved behandling av pasienter med stadium I eller stadium II tykktarmskreft som ble fjernet ved kirurgi.

Studieoversikt

Status

Avsluttet

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

MÅL:

Hoved

  • For å sammenligne effekten av rosuvastatin vs placebo på 5-års forekomst av adenomatøse polypper i tykktarmen eller rektum, metakront kolorektalt karsinom eller residiv av tykktarmskreft (APMC+R) hos pasienter med reseksjonert stadium I eller II tykktarmskreft.

Sekundær

  • For å bestemme om effekten av rosuvastatin vs placebo er av samme størrelsesorden hos pasienter som tar aspirin (uavhengig av dose) sammenlignet med pasienter som ikke tar aspirin.
  • For å avgjøre om å ta aspirin (uavhengig av dose) vs ingen aspirin vil redusere forekomsten eller APMC+R og, hvis det er en effekt, for å utforske forholdet til dose.
  • For å bestemme effekten av rosuvastatin hos pasienter med familiær kolorektal kreft.
  • For å bestemme effekten av rosuvastatin hos pasienter med mikrosatellitt-ustabile svulster (dvs. svulster som viser tap av MLH1- eller MSH2-ekspresjon av IHC).
  • For å bestemme forholdet mellom rosuvastatinbehandling og trekk ved kolorektale adenomer samt størrelse og antall kolorektale adenomer.
  • For å sammenligne tiden med APMC+R hos pasienter behandlet med rosuvastatin vs placebo.
  • For å sammenligne den sykdomsfrie overlevelsen til pasienter behandlet med rosuvastatin vs placebo.
  • For å sammenligne den totale overlevelsen til pasienter behandlet med rosuvastatin vs placebo.
  • For å sammenligne frekvensen av tilbakefall av tykktarmskreft hos pasienter behandlet med rosuvastatin vs placebo.
  • For å sammenligne frekvensen av andre ikke-kolorektale primære kreftformer hos pasienter behandlet med rosuvastatin vs placebo.
  • For å bestemme effekten av rosuvastatin på helserelatert livskvalitet, global livskvalitet og selvrapporterte symptomer.
  • For å sammenligne forekomsten og alvorlighetsgraden av bivirkninger forbundet med rosuvastatin vs placebo.
  • For å vurdere relevante tumor- og blodmarkører som kan påvirke metabolismen, aktiviteten eller effekten av studiemedikamentene, slik som HMG-CoA-reduktase, UGT1A6, P450-2C9, PTGS2 (COX-2) og andre mulige markører.

OVERSIKT: Dette er en multisenterstudie. Pasientene er stratifisert i henhold til familiehistorien til en førstegradsslektning med tykktarmskreft (ja vs nei), tiltenkt aspirindose (ingen vs 81 mg vs 325 mg) og adjuvant behandling for tykktarmskreft (ja vs nei). Pasientene er randomisert til 1 av 2 behandlingsarmer.

  • Gruppe 1: Pasienter får oral placebo én gang daglig i 5 år.
  • Gruppe 2: Pasienter får oralt rosuvastatin én gang daglig i 5 år.

Pasienter kan fylle ut et livskvalitetsspørreskjema ved baseline og ved 6, 12, 36, 60 og 84 måneder.

Tumorvev, serum og blodprøver kan tas med jevne mellomrom for biomarkør og andre analyser.

Etter avsluttet studiebehandling følges pasientene opp periodisk i inntil 2 år.

Studietype

Intervensjonell

Registrering (Faktiske)

406

Fase

  • Fase 3

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiesteder

  • Canada
    • Ontario
      • Kingston, Ontario, Canada, K7L 5P9
        • Cancer Centre of Southeastern Ontario at Kingston General Hospital
    • Quebec
      • Montreal, Quebec, Canada, H3A 1A1
        • Royal Victoria Hospital - Montreal
      • Quebec City, Quebec, Canada, G1S 4L8
        • Hopital du Saint-Sacrement - Quebec
  • Forente stater
    • Alabama
      • Anniston, Alabama, Forente stater, 36207
        • Regional Medical Center
      • Mobile, Alabama, Forente stater, 36608
        • Providence Cancer Center at Providence Hospital
    • Arkansas
      • Fort Smith, Arkansas, Forente stater, 72903
        • Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
      • Little Rock, Arkansas, Forente stater, 72205
        • Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
      • Little Rock, Arkansas, Forente stater, 72205
    • California
      • Anaheim, California, Forente stater, 92807
        • Kaiser Permanente Medical Center - Anaheim/Orange County
      • Antioch, California, Forente stater, 94531
        • Kaiser Permanente - Deer Valley
      • Baldwin Park, California, Forente stater, 91706
        • Kaiser Permanente Medical Center - Baldwin Park
      • Bellflower, California, Forente stater, 90706
        • Kaiser Permanente Medical Center - Bellflower
      • Castro Valley, California, Forente stater, 94546
        • East Bay Radiation Oncology Center
      • Castro Valley, California, Forente stater, 94546
        • Valley Medical Oncology Consultants - Castro Valley
      • Fairfield, California, Forente stater, 94533
        • North Bay Cancer Center
      • Fontana, California, Forente stater, 92335
        • Kaiser Permanente Medical Center - Fontana
      • Fremont, California, Forente stater, 94538
        • Kaiser Permanente - Fremont
      • Fremont, California, Forente stater, 94538
        • Valley Medical Oncology
      • Fullerton, California, Forente stater, 92835
        • Virginia K. Crosson Cancer Center At St. Jude Medical Center
      • Glendale, California, Forente stater, 91204
        • Glendale Memorial Hospital Comprehensive Cancer Center
      • Harbor City, California, Forente stater, 90710
        • Kaiser Permanente Medical Center - Harbor City
      • Hayward, California, Forente stater, 94545
        • Kaiser Permanente Medical Center - Hayward
      • Irvine, California, Forente stater, 92618
        • Kaiser Permanente - Irvine
      • Los Angeles, California, Forente stater, 90027
        • Kaiser Permanente Medical Center - Los Angeles
      • Los Angeles, California, Forente stater, 90034
        • Kaiser Foundation Hospital - West Los Angeles
      • Martinez, California, Forente stater, 94553-3156
        • Contra Costa Regional Medical Center
      • Modesto, California, Forente stater, 95355
        • Memorial Medical Center
      • Mountain View, California, Forente stater, 94040
        • El Camino Hospital Cancer Center
      • Mountain View, California, Forente stater, 94040
        • Camino Medical Group - Treatment Center
      • Oakland, California, Forente stater, 94609
        • Alta Bates Summit Medical Center - Summit Campus
      • Oakland, California, Forente stater, 94602
        • Highland General Hospital
      • Oakland, California, Forente stater, 94609
        • Larry G Strieff MD Medical Corporation
      • Oakland, California, Forente stater, 94609
        • CCOP - Bay Area Tumor Institute
      • Oakland, California, Forente stater, 94609
        • Bay Area Breast Surgeons, Incorporated
      • Oakland, California, Forente stater, 94609
        • Tom K Lee, Incorporated
      • Oakland, California, Forente stater, 94611
        • Kaiser Permanente Medical Center - Oakland
      • Oakland, California, Forente stater, 94612
        • Epic Care - Oakland
      • Ontario, California, Forente stater, 91761
        • Kaiser Permanente - Ontario Vineyard Medical Offices and Ambulatory SurgiCenter
      • Orange, California, Forente stater, 92868
        • St. Joseph Hospital Regional Cancer Center - Orange
      • Palo Alto, California, Forente stater, 94301
        • Palo Alto Medical Foundation
      • Panorama City, California, Forente stater, 91402
        • Kaiser Permanente Medical Group
      • Rancho Mirage, California, Forente stater, 92270
        • Lucy Curci Cancer Center at Eisenhower Memorial Hospital and Medical Center
      • Redwood City, California, Forente stater, 94063
        • Kaiser Permanente Medical Center - Redwood City
      • Richmond, California, Forente stater, 94801
        • Kaiser Permanente Medical Center - Richmond
      • Riverside, California, Forente stater, 92505
        • Kaiser Permanente Medical Center - Riverside
      • Roseville, California, Forente stater, 95661
        • Kaiser Permanente Medical Center - Roseville
      • Sacramento, California, Forente stater, 95823
        • South Sacramento Kaiser-Permanente Medical Center
      • Sacramento, California, Forente stater, 95825
        • Kaiser Permanente Medical Center - Sacramento
      • Salinas, California, Forente stater, 93901
        • Salinas Valley Memorial Hospital
      • San Diego, California, Forente stater, 92120
        • Kaiser Permanente Medical Center - Kaiser Foundation Hospital - San Diego
      • San Diego, California, Forente stater, 92108
        • Kaiser Permanente Medical Office -Vandever Medical Office
      • San Francisco, California, Forente stater, 94115
        • Kaiser Permanente Medical Center - San Francisco Geary Campus
      • San Jose, California, Forente stater, 95119
        • Kaiser Permanente Medical Center - Santa Teresa
      • San Marcos, California, Forente stater, 92078
        • Kaiser Permanente Health Care
      • San Pablo, California, Forente stater, 94806
        • Doctors Medical Center - San Pablo Campus
      • San Rafael, California, Forente stater, 94903
        • Kaiser Foundation Hospital - San Rafael
      • Santa Clara, California, Forente stater, 95051
        • Kaiser Permanente Medical Center - Santa Clara Kiely Campus
      • Santa Rosa, California, Forente stater, 95403
        • Kaiser Permanente Medical Center - Santa Rosa
      • South San Francisco, California, Forente stater, 94080
        • Kaiser Permanente Medical Center - South San Francisco
      • Stanford, California, Forente stater, 94305-5824
        • Stanford Cancer Center
      • Stockton, California, Forente stater, 95210
        • Kaiser Permanente Medical Facility - Stockton
      • Vacaville, California, Forente stater, 95688
        • Kaiser Permanente Medical Center - Vacaville
      • Vallejo, California, Forente stater, 94589
        • Kaiser Permanente Medical Center - Vallejo
      • Walnut Creek, California, Forente stater, 94596
        • Kaiser Permanente Medical Center - Walnut Creek
      • Woodland Hills, California, Forente stater, 91367
        • Kaiser Permanente Medical Cener - Woodland Hills
    • Colorado
      • Aurora, Colorado, Forente stater, 80012
        • Aurora Presbyterian Hospital
      • Boulder, Colorado, Forente stater, 80301-9019
        • Boulder Community Hospital
      • Colorado Springs, Colorado, Forente stater, 80933
        • Penrose Cancer Center at Penrose Hospital
      • Denver, Colorado, Forente stater, 80210
        • Porter Adventist Hospital
      • Denver, Colorado, Forente stater, 80220
        • Rose Medical Center
      • Denver, Colorado, Forente stater, 80218
        • Presbyterian - St. Luke's Medical Center
      • Denver, Colorado, Forente stater, 80204
        • St. Anthony Central Hospital
      • Denver, Colorado, Forente stater, 80218
        • St. Joseph Hospital
      • Denver, Colorado, Forente stater, 80222
        • CCOP - Colorado Cancer Research Program
      • Denver, Colorado, Forente stater, 80205
        • Kaiser Permanente - Denver
      • Englewood, Colorado, Forente stater, 80110
        • Swedish Medical Center
      • Fort Collins, Colorado, Forente stater, 80524
        • Poudre Valley Hospital
      • Fort Collins, Colorado, Forente stater, 80528
        • Front Range Cancer Specialists
      • Grand Junction, Colorado, Forente stater, 81502
        • St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
      • Greeley, Colorado, Forente stater, 80631
        • North Colorado Medical Center
      • Lafayette, Colorado, Forente stater, 80026
        • Kaiser Permanente - Lafayette
      • Littleton, Colorado, Forente stater, 80122
        • Littleton Adventist Hospital
      • Lone Tree, Colorado, Forente stater, 80124
        • Sky Ridge Medical Center
      • Longmont, Colorado, Forente stater, 80501
        • Hope Cancer Care Center at Longmont United Hospital
      • Loveland, Colorado, Forente stater, 80539
        • McKee Medical Center
      • Parker, Colorado, Forente stater, 80138
        • Parker Adventist Hospital
      • Pueblo, Colorado, Forente stater, 81004
        • St. Mary - Corwin Regional Medical Center
      • Thornton, Colorado, Forente stater, 80229
        • North Suburban Medical Center
      • Wheat Ridge, Colorado, Forente stater, 80033
        • Exempla Lutheran Medical Center
    • Connecticut
      • Farmington, Connecticut, Forente stater, 06360-2875
        • Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center
      • Greenwich, Connecticut, Forente stater, 06830
        • Bendheim Cancer Center at Greenwich Hospital
      • Hartford, Connecticut, Forente stater, 06105
        • Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
      • Hartford, Connecticut, Forente stater, 06102-5037
        • Helen and Harry Gray Cancer Center at Hartford Hospital
      • Middletown, Connecticut, Forente stater, 06457
        • Middlesex Hospital Cancer Center
      • Stamford, Connecticut, Forente stater, 06904
        • Carl and Dorothy Bennett Cancer Center at Stamford Hospital
    • Delaware
      • Dover, Delaware, Forente stater, 19901
        • Kent General Hospital
      • Lewes, Delaware, Forente stater, 19958
        • Tunnell Cancer Center at Beebe Medical Center
      • Newark, Delaware, Forente stater, 19713
        • CCOP - Christiana Care Health Services
    • District of Columbia
      • Washington, District of Columbia, Forente stater, 20010
        • Washington Cancer Institute at Washington Hospital Center
      • Washington, District of Columbia, Forente stater, 20002
        • Kaiser Permanente at Capitol Hill Medical Center
    • Florida
      • Fort Lauderdale, Florida, Forente stater, 33308
        • Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
      • Gainesville, Florida, Forente stater, 32610-0232
        • University of Florida Shands Cancer Center
      • Jacksonville, Florida, Forente stater, 32204
        • St. Vincent's Medical Center
      • Jacksonville, Florida, Forente stater, 32207
        • Baptist Cancer Institute - Jacksonville
      • Jupiter, Florida, Forente stater, 33458
        • Ella Milbank Foshay Cancer Center at Jupiter Medical Center
      • Miami Beach, Florida, Forente stater, 33140
        • CCOP - Mount Sinai Medical Center
      • Sarasota, Florida, Forente stater, 34236
        • Florida Cancer Specialists - Sarasota Downtown
      • Weston, Florida, Forente stater, 33331
        • Cleveland Clinic Florida - Weston
    • Georgia
      • Albany, Georgia, Forente stater, 31701
        • Phoebe Cancer Center at Phoebe Putney Memorial Hospital
      • Atlanta, Georgia, Forente stater, 30309
        • Piedmont Hospital
      • Atlanta, Georgia, Forente stater, 30342-1611
        • Northside Hospital Cancer Center
      • Atlanta, Georgia, Forente stater, 30342-1701
        • Saint Joseph's Hospital of Atlanta
      • Atlanta, Georgia, Forente stater, 30342
        • CCOP - Atlanta Regional
      • Augusta, Georgia, Forente stater, 30912
        • MBCCOP - Medical College of Georgia Cancer Center
      • Austell, Georgia, Forente stater, 30106
        • WellStar Cobb Hospital
      • Columbus, Georgia, Forente stater, 31904
        • John B. Amos Cancer Center
      • Decatur, Georgia, Forente stater, 30033
        • Charles B. Eberhart Cancer Center at DeKalb Medical Center
      • Fayetteville, Georgia, Forente stater, 30214
        • Piedmont Fayette Hospital
      • Lawrenceville, Georgia, Forente stater, 30045
        • Gwinnett Medical Center
      • Marietta, Georgia, Forente stater, 30060
        • Kennestone Cancer Center at Wellstar Kennestone Hospital
      • Riverdale, Georgia, Forente stater, 30274-2600
        • Southern Regional Medical Center
      • Rome, Georgia, Forente stater, 30165
        • Harbin Clinic Cancer Center - Medical Oncology
      • Savannah, Georgia, Forente stater, 31405
        • Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
    • Hawaii
      • Honolulu, Hawaii, Forente stater, 96813
        • Cancer Research Center of Hawaii
      • Honolulu, Hawaii, Forente stater, 96813
        • OnCare Hawaii, Incorporated - Lusitana
      • Honolulu, Hawaii, Forente stater, 96813
        • Queen's Cancer Institute at Queen's Medical Center
      • Honolulu, Hawaii, Forente stater, 96813
        • Straub Clinic and Hospital, Incorporated
      • Honolulu, Hawaii, Forente stater, 96817
        • OnCare Hawaii, Incorporated - Kuakini
      • Honolulu, Hawaii, Forente stater, 96859
        • Tripler Army Medical Center
      • Honolulu, Hawaii, Forente stater, 96819
        • Kaiser Permanente - Moanalua Medical Center and Clinic
    • Idaho
      • Boise, Idaho, Forente stater, 83706
        • Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
      • Lewiston, Idaho, Forente stater, 83501
        • St. Joseph Regional Medical Center
    • Illinois
      • Aurora, Illinois, Forente stater, 60504
        • Rush-Copley Cancer Care Center
      • Bloomington, Illinois, Forente stater, 61701
        • Illinois CancerCare - Bloomington
      • Bloomington, Illinois, Forente stater, 61701
        • St. Joseph Medical Center
      • Canton, Illinois, Forente stater, 61520
        • Illinois CancerCare - Canton
      • Canton, Illinois, Forente stater, 61520
        • Graham Hospital
      • Carthage, Illinois, Forente stater, 62321
        • Memorial Hospital
      • Carthage, Illinois, Forente stater, 62321
        • Illinois CancerCare - Carthage
      • Chicago, Illinois, Forente stater, 60640
        • Louis A. Weiss Memorial Hospital
      • Chicago, Illinois, Forente stater, 60608
        • Mount Sinai Hospital Medical Center
      • Chicago, Illinois, Forente stater, 60631
        • Resurrection Medical Center
      • Decatur, Illinois, Forente stater, 62526
        • Decatur Memorial Hospital Cancer Care Institute
      • Elgin, Illinois, Forente stater, 60123
        • Sherman Hospital
      • Elk Grove Village, Illinois, Forente stater, 60007
        • Alexian Brothers Radiation Oncology
      • Elmhurst, Illinois, Forente stater, 60126
        • Elmhurst Memorial Hospital
      • Eureka, Illinois, Forente stater, 61530
        • Illinois CancerCare - Eureka
      • Eureka, Illinois, Forente stater, 61530
        • Eureka Community Hospital
      • Galesburg, Illinois, Forente stater, 61401
        • Illinois CancerCare - Galesburg
      • Galesburg, Illinois, Forente stater, 61401
        • Galesburg Clinic, PC
      • Harvey, Illinois, Forente stater, 60426
        • Ingalls Cancer Care Center at Ingalls Memorial Hospital
      • Havana, Illinois, Forente stater, 62644
        • Mason District Hospital
      • Havana, Illinois, Forente stater, 62644
        • Illinois CancerCare - Havana
      • Hinsdale, Illinois, Forente stater, 60521
        • Hinsdale Hematology Oncology Associates
      • Joliet, Illinois, Forente stater, 60435
        • Joliet Oncology-Hematology Associates, Limited - West
      • Kewanee, Illinois, Forente stater, 61443
        • Illinois CancerCare - Kewanee Clinic
      • La Grange, Illinois, Forente stater, 60525
        • La Grange Memorial Hospital
      • Macomb, Illinois, Forente stater, 61455
        • Illinois CancerCare - Macomb
      • Macomb, Illinois, Forente stater, 61455
        • Mcdonough District Hospital
      • Moline, Illinois, Forente stater, 61265
      • Moline, Illinois, Forente stater, 61265
        • Trinity Cancer Center at Trinity Medical Center - 7th Street Campus
      • Monmouth, Illinois, Forente stater, 61462
        • Illinois CancerCare - Monmouth
      • Monmouth, Illinois, Forente stater, 61462
        • OSF Holy Family Medical Center
      • Naperville, Illinois, Forente stater, 60540
        • Edward Hospital Cancer Center
      • Normal, Illinois, Forente stater, 61761
        • Bromenn Regional Medical Center
      • Normal, Illinois, Forente stater, 61761
        • Community Cancer Center
      • Normal, Illinois, Forente stater, 61761
        • Illinois CancerCare - Community Cancer Center
      • Oak Lawn, Illinois, Forente stater, 60453-2699
        • Advocate Christ Medical Center
      • Ottawa, Illinois, Forente stater, 61350
        • Community Hospital of Ottawa
      • Ottawa, Illinois, Forente stater, 61350
        • Oncology Hematology Associates of Central Illinois, PC - Ottawa
      • Park Ridge, Illinois, Forente stater, 60068-1174
        • Advocate Lutheran General Cancer Care Center
      • Pekin, Illinois, Forente stater, 61554
        • Cancer Treatment Center at Pekin Hospital
      • Pekin, Illinois, Forente stater, 61603
        • Illinois CancerCare - Pekin
      • Peoria, Illinois, Forente stater, 61636
        • Methodist Medical Center of Illinois
      • Peoria, Illinois, Forente stater, 61614
        • Proctor Hospital
      • Peoria, Illinois, Forente stater, 61637
        • OSF St. Francis Medical Center
      • Peoria, Illinois, Forente stater, 61615
        • CCOP - Illinois Oncology Research Association
      • Peoria, Illinois, Forente stater, 61615
        • Oncology Hematology Associates of Central Illinois, PC - Peoria
      • Peru, Illinois, Forente stater, 61354
        • Illinois CancerCare - Peru
      • Peru, Illinois, Forente stater, 61354
        • Illinois Valley Community Hospital
      • Princeton, Illinois, Forente stater, 61356
        • Perry Memorial Hospital
      • Princeton, Illinois, Forente stater, 61356
        • Illinois CancerCare - Princeton
      • River Forest, Illinois, Forente stater, 60305
        • West Suburban Center for Cancer Care
      • Rockford, Illinois, Forente stater, 61104-2315
        • Swedish-American Regional Cancer Center
      • Rockford, Illinois, Forente stater, 61108
        • Center for Cancer Care at OSF Saint Anthony Medical Center
      • Spring Valley, Illinois, Forente stater, 61362
        • Illinois CancerCare - Spring Valley
      • Springfield, Illinois, Forente stater, 62781-0001
        • Regional Cancer Center at Memorial Medical Center
      • Urbana, Illinois, Forente stater, 61801
        • CCOP - Carle Cancer Center
    • Indiana
      • Beech Grove, Indiana, Forente stater, 46107
        • St. Francis Hospital and Health Centers - Beech Grove Campus
      • Elkhart, Indiana, Forente stater, 46515
        • Elkhart General Hospital
      • Elkhart, Indiana, Forente stater, 46514-2098
        • Elkhart Clinic, LLC
      • Elkhart, Indiana, Forente stater, 46514
        • Michiana Hematology-Oncology, PC - Elkhart
      • Indianapolis, Indiana, Forente stater, 46260
        • St. Vincent Indianapolis Hospital
      • Kokomo, Indiana, Forente stater, 46904
        • Howard Community Hospital
      • La Porte, Indiana, Forente stater, 46350
        • Center for Cancer Therapy at LaPorte Hospital and Health Services
      • Michigan City, Indiana, Forente stater, 46360
        • Saint Anthony Memorial Health Centers
      • Mishawaka, Indiana, Forente stater, 46545-1470
        • Michiana Hematology-Oncology, PC - South Bend
      • Mishawaka, Indiana, Forente stater, 46545-1470
        • Saint Joseph Regional Medical Center
      • Munster, Indiana, Forente stater, 46321
        • Community Hospital
      • Plymouth, Indiana, Forente stater, 46563
        • Michiana Hematology Oncology PC - Plymouth
      • Richmond, Indiana, Forente stater, 47374
        • Reid Hospital & Health Care Services
      • South Bend, Indiana, Forente stater, 46601
        • Memorial Hospital of South Bend
      • South Bend, Indiana, Forente stater, 46601
        • CCOP - Northern Indiana CR Consortium
      • Westville, Indiana, Forente stater, 46391
        • Michiana Hematology Oncology PC - La Porte
    • Iowa
      • Ames, Iowa, Forente stater, 50010
        • McFarland Clinic, PC
      • Bettendorf, Iowa, Forente stater, 52722
      • Bettendorf, Iowa, Forente stater, 52722
        • Hematology Oncology Associates of the Quad Cities
      • Cedar Rapids, Iowa, Forente stater, 52403
        • Cedar Rapids Oncology Associates
      • Cedar Rapids, Iowa, Forente stater, 52403
        • Mercy Regional Cancer Center at Mercy Medical Center
      • Clive, Iowa, Forente stater, 50325
        • Medical Oncology and Hematology Associates - West Des Moines
      • Clive, Iowa, Forente stater, 50325
        • Mercy Cancer Center - West Lakes
      • Davenport, Iowa, Forente stater, 52803
        • Genesis Regional Cancer Center at Genesis Medical Center
      • Des Moines, Iowa, Forente stater, 50309
        • CCOP - Iowa Oncology Research Association
      • Des Moines, Iowa, Forente stater, 50309
        • John Stoddard Cancer Center at Iowa Methodist Medical Center
      • Des Moines, Iowa, Forente stater, 50309
        • Medical Oncology and Hematology Associates at John Stoddard Cancer Center
      • Des Moines, Iowa, Forente stater, 50314
        • Medical Oncology and Hematology Associates at Mercy Cancer Center
      • Des Moines, Iowa, Forente stater, 50314
        • Mercy Cancer Center at Mercy Medical Center - Des Moines
      • Des Moines, Iowa, Forente stater, 50316
        • John Stoddard Cancer Center at Iowa Lutheran Hospital
      • Iowa City, Iowa, Forente stater, 52242-1002
        • Holden Comprehensive Cancer Center at University of Iowa
      • Mason City, Iowa, Forente stater, 50401
        • Mercy Cancer Center at Mercy Medical Center - North Iowa
      • Ottumwa, Iowa, Forente stater, 52501
        • McCreery Cancer Center at Ottumwa Regional
      • Sioux City, Iowa, Forente stater, 51101
        • Siouxland Hematology-Oncology Associates, LLP
      • Sioux City, Iowa, Forente stater, 51102
        • Mercy Medical Center - Sioux City
      • Sioux City, Iowa, Forente stater, 51104
        • St. Luke's Regional Medical Center
      • Waterloo, Iowa, Forente stater, 50702
        • Covenant Cancer Treatment Center
      • West Des Moines, Iowa, Forente stater, 50266-7700
        • Methodist West Hospital
    • Kansas
      • Chanute, Kansas, Forente stater, 66720
        • Cancer Center of Kansas, PA - Chanute
      • Dodge City, Kansas, Forente stater, 67801
        • Cancer Center of Kansas, PA - Dodge City
      • El Dorado, Kansas, Forente stater, 67042
        • Cancer Center of Kansas, PA - El Dorado
      • Fort Scott, Kansas, Forente stater, 66701
        • Cancer Center of Kansas - Fort Scott
      • Independence, Kansas, Forente stater, 67301
        • Cancer Center of Kansas-Independence
      • Kingman, Kansas, Forente stater, 67068
        • Cancer Center of Kansas, PA - Kingman
      • Lawrence, Kansas, Forente stater, 66044
        • Lawrence Memorial Hospital
      • Liberal, Kansas, Forente stater, 67901
        • Cancer Center of Kansas, PA - Liberal
      • McPherson, Kansas, Forente stater, 67460
        • Cancer Center of Kansas, PA - McPherson
      • Newton, Kansas, Forente stater, 67114
        • Cancer Center of Kansas, PA - Newton
      • Overland Park, Kansas, Forente stater, 66209
        • Menorah Medical Center
      • Overland Park, Kansas, Forente stater, 66213
        • Saint Luke's Hospital - South
      • Parsons, Kansas, Forente stater, 67357
        • Cancer Center of Kansas, PA - Parsons
      • Prairie Village, Kansas, Forente stater, 66208
        • CCOP - Kansas City
      • Pratt, Kansas, Forente stater, 67124
        • Cancer Center of Kansas, PA - Pratt
      • Salina, Kansas, Forente stater, 67401
        • Cancer Center of Kansas, PA - Salina
      • Topeka, Kansas, Forente stater, 66606
        • Cotton-O'Neil Cancer Center
      • Wellington, Kansas, Forente stater, 67152
        • Cancer Center of Kansas, PA - Wellington
      • Wichita, Kansas, Forente stater, 67208
        • Cancer Center of Kansas, PA - Medical Arts Tower
      • Wichita, Kansas, Forente stater, 67214
        • Cancer Center of Kansas, PA - Wichita
      • Wichita, Kansas, Forente stater, 67214
        • CCOP - Wichita
      • Wichita, Kansas, Forente stater, 67214
        • Via Christi Cancer Center at Via Christi Regional Medical Center
      • Wichita, Kansas, Forente stater, 67208
        • Associates in Womens Health, PA - North Review
      • Winfield, Kansas, Forente stater, 67156
        • Cancer Center of Kansas, PA - Winfield
    • Kentucky
      • Lexington, Kentucky, Forente stater, 40503-9985
        • Central Baptist Hospital
      • Louisville, Kentucky, Forente stater, 40202
        • Louisville Oncology at Norton Cancer Institute - Louisville
    • Louisiana
      • Alexandria, Louisiana, Forente stater, 71315-3198
        • Tulane Cancer Center Office of Clinical Research
      • Alexandria, Louisiana, Forente stater, 71301
        • CHRISTUS Cabrini Cancer Center
      • Baton Rouge, Louisiana, Forente stater, 70809
        • Mary Bird Perkins Cancer Center - Baton Rouge
      • Baton Rouge, Louisiana, Forente stater, 70809
        • Hematology-Oncology Clinic
      • Monroe, Louisiana, Forente stater, 71210
        • Louisiana State University Health Sciences Center - Monroe
      • New Orleans, Louisiana, Forente stater, 70121
        • CCOP - Ochsner
      • New Orleans, Louisiana, Forente stater, 70112
        • MBCCOP - LSU Health Sciences Center
      • New Orleans, Louisiana, Forente stater, 70121
        • Ochsner Cancer Institute at Ochsner Clinic Foundation
      • New Orleans, Louisiana, Forente stater, 70112
        • Medical Center of Louisiana - New Orleans
      • Shreveport, Louisiana, Forente stater, 71105
        • Highland Clinic
      • Shreveport, Louisiana, Forente stater, 71130-3932
        • Feist-Weiller Cancer Center at Louisiana State University Health Sciences
    • Maine
      • Augusta, Maine, Forente stater, 04330
        • Harold Alfond Center for Cancer Care
      • Bangor, Maine, Forente stater, 04401
        • CancerCare of Maine at Eastern Maine Medical Center
      • Portland, Maine, Forente stater, 04101
        • Mercy Hospital
    • Maryland
      • Baltimore, Maryland, Forente stater, 21237
        • Harry and Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center
      • Baltimore, Maryland, Forente stater, 21244
        • Kaiser Permanente at Woodlawn Medical Center
      • Easton, Maryland, Forente stater, 21601
        • Shore Regional Cancer Center at Memorial Hospital - Easton
      • Elkton, Maryland, Forente stater, 21921
        • Union Hospital of Cecil County
      • Frederick, Maryland, Forente stater, 21701
        • Frederick Memorial Hospital Regional Cancer Therapy Center
      • Gaithersburg, Maryland, Forente stater, 20879
        • Kaiser Permanente - Gaithersburg Medical Center
      • Largo, Maryland, Forente stater, 20774
        • Kaiser Permanente Mid-Atlantic Medical Group-Largo Medical Facility
      • Salisbury, Maryland, Forente stater, 21801
        • Peninsula Regional Medical Center
    • Massachusetts
      • Boston, Massachusetts, Forente stater, 02118
        • Boston University Cancer Research Center
      • Burlington, Massachusetts, Forente stater, 01805
        • Lahey Clinic Medical Center - Burlington
      • Fairhaven, Massachusetts, Forente stater, 02719
        • Southcoast Center for Cancer Care
      • Fall River, Massachusetts, Forente stater, 02721
        • Hudner Oncology Center at Saint Anne's Hospital - Fall River
      • Pittsfield, Massachusetts, Forente stater, 01201
        • Berkshire Hematology Oncology, PC
    • Michigan
      • Ann Arbor, Michigan, Forente stater, 48106-0995
        • Saint Joseph Mercy Cancer Center
      • Ann Arbor, Michigan, Forente stater, 48106
        • CCOP - Michigan Cancer Research Consortium
      • Battle Creek, Michigan, Forente stater, 49017
        • Battle Creek Health System Cancer Care Center
      • Big Rapids, Michigan, Forente stater, 49307
        • Mecosta County Medical Center
      • Dearborn, Michigan, Forente stater, 48123-2500
        • Oakwood Cancer Center at Oakwood Hospital and Medical Center
      • Detroit, Michigan, Forente stater, 48202
        • Josephine Ford Cancer Center at Henry Ford Hospital
      • Escanaba, Michigan, Forente stater, 49431
        • Green Bay Oncology, Limited - Escanaba
      • Flint, Michigan, Forente stater, 48503
        • Hurley Medical Center
      • Flint, Michigan, Forente stater, 48503
        • Genesys Hurley Cancer Institute
      • Grand Rapids, Michigan, Forente stater, 49503
        • Butterworth Hospital at Spectrum Health
      • Grand Rapids, Michigan, Forente stater, 49503
        • CCOP - Grand Rapids
      • Grand Rapids, Michigan, Forente stater, 49503
        • Lacks Cancer Center at Saint Mary's Health Care
      • Grosse Pointe Woods, Michigan, Forente stater, 48236
        • Van Elslander Cancer Center at St. John Hospital and Medical Center
      • Iron Mountain, Michigan, Forente stater, 49801
        • Dickinson County Healthcare System
      • Jackson, Michigan, Forente stater, 49201
        • Foote Memorial Hospital
      • Kalamazoo, Michigan, Forente stater, 49007
        • Bronson Methodist Hospital
      • Kalamazoo, Michigan, Forente stater, 49001
        • Borgess Medical Center
      • Kalamazoo, Michigan, Forente stater, 49007-3731
        • West Michigan Cancer Center
      • Lansing, Michigan, Forente stater, 48912-1811
        • Sparrow Regional Cancer Center
      • Lansing, Michigan, Forente stater, 48910
        • Breslin Cancer Center at Ingham Regional Medical Center
      • Livonia, Michigan, Forente stater, 48154
        • St. Mary Mercy Hospital
      • Marquette, Michigan, Forente stater, 49855
        • Upper Michigan Cancer Center at Marquette General Hospital
      • Muskegon, Michigan, Forente stater, 49444
        • Mercy General Health Partners
      • Pontiac, Michigan, Forente stater, 48341-2985
        • St. Joseph Mercy Oakland
      • Port Huron, Michigan, Forente stater, 48060
        • Mercy Regional Cancer Center at Mercy Hospital
      • Reed City, Michigan, Forente stater, 49677
        • Spectrum Health Reed City Hospital
      • Royal Oak, Michigan, Forente stater, 48073
        • William Beaumont Hospital - Royal Oak Campus
      • Saginaw, Michigan, Forente stater, 48601
        • Seton Cancer Institute at Saint Mary's - Saginaw
      • Saint Joseph, Michigan, Forente stater, 49085
        • Lakeside Cancer Specialists, PLLC
      • Saint Joseph, Michigan, Forente stater, 49085
        • Lakeland Regional Cancer Care Center - St. Joseph
      • Traverse City, Michigan, Forente stater, 49684
        • Munson Medical Center
      • Warren, Michigan, Forente stater, 48093
        • St. John Macomb Hospital
    • Minnesota
      • Brainerd, Minnesota, Forente stater, 56401
        • St. Joseph's Medical Center
      • Burnsville, Minnesota, Forente stater, 55337
        • Fairview Ridges Hospital
      • Coon Rapids, Minnesota, Forente stater, 55433
        • Mercy and Unity Cancer Center at Mercy Hospital
      • Duluth, Minnesota, Forente stater, 55805
        • CCOP - Duluth
      • Duluth, Minnesota, Forente stater, 55805-1983
        • Duluth Clinic Cancer Center - Duluth
      • Duluth, Minnesota, Forente stater, 55805
        • Miller - Dwan Medical Center
      • Duluth, Minnesota, Forente stater, 55805
        • St. Luke's Hospital Cancer Care Center
      • Edina, Minnesota, Forente stater, 55435
        • Fairview Southdale Hospital
      • Fridley, Minnesota, Forente stater, 55432
        • Mercy and Unity Cancer Center at Unity Hospital
      • Hutchinson, Minnesota, Forente stater, 55350
        • Hutchinson Area Health Care
      • Mankato, Minnesota, Forente stater, 56002
        • Immanuel St. Joseph's
      • Maplewood, Minnesota, Forente stater, 55109
        • HealthEast Cancer Care at St. John's Hospital
      • Maplewood, Minnesota, Forente stater, 55109
        • Minnesota Oncology - Maplewood
      • Minneapolis, Minnesota, Forente stater, 55407
        • Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
      • Minneapolis, Minnesota, Forente stater, 55415
        • Hennepin County Medical Center - Minneapolis
      • New Ulm, Minnesota, Forente stater, 56073
        • New Ulm Medical Center
      • Robbinsdale, Minnesota, Forente stater, 55422-2900
        • Humphrey Cancer Center at North Memorial Outpatient Center
      • Rochester, Minnesota, Forente stater, 55905
        • Mayo Clinic Cancer Center
      • Saint Louis Park, Minnesota, Forente stater, 55416
        • CCOP - Metro-Minnesota
      • Saint Louis Park, Minnesota, Forente stater, 55416
        • Park Nicollet Cancer Center
      • Saint Paul, Minnesota, Forente stater, 55102
        • United Hospital
      • Saint Paul, Minnesota, Forente stater, 55101
        • Regions Hospital Cancer Care Center
      • Shakopee, Minnesota, Forente stater, 55379
        • St. Francis Cancer Center at St. Francis Medical Center
      • Stillwater, Minnesota, Forente stater, 55082
        • Lakeview Hospital
      • Waconia, Minnesota, Forente stater, 55387
        • Ridgeview Medical Center
      • Willmar, Minnesota, Forente stater, 56201
        • Willmar Cancer Center at Rice Memorial Hospital
      • Woodbury, Minnesota, Forente stater, 55125
        • Minnesota Oncology - Woodbury
    • Missouri
      • Bolivar, Missouri, Forente stater, 65613
        • Central Care Cancer Center at Carrie J. Babb Cancer Center
      • Cape Girardeau, Missouri, Forente stater, 63703
        • Southeast Cancer Center
      • Chesterfield, Missouri, Forente stater, 63017
        • Saint Luke's Hospital
      • Jefferson City, Missouri, Forente stater, 65109
        • Goldschmidt Cancer Center
      • Kansas City, Missouri, Forente stater, 64116
        • North Kansas City Hospital
      • Kansas City, Missouri, Forente stater, 64132
        • Research Medical Center
      • Kansas City, Missouri, Forente stater, 64111
        • Saint Luke's Cancer Institute at Saint Luke's Hospital
      • Kansas City, Missouri, Forente stater, 64118
        • Heartland Hematology Oncology Associates, Incorporated
      • Lee's Summit, Missouri, Forente stater, 64086
        • Saint Luke's East - Lee's Summit
      • Liberty, Missouri, Forente stater, 64068
        • Parvin Radiation Oncology
      • Rolla, Missouri, Forente stater, 65401
        • Phelps County Regional Medical Center
      • Saint Joseph, Missouri, Forente stater, 64506
        • Heartland Regional Medical Center
      • Saint Joseph, Missouri, Forente stater, 64507
        • Saint Joseph Oncology, Incorporated
      • Saint Louis, Missouri, Forente stater, 63131
        • Missouri Baptist Cancer Center
      • Saint Louis, Missouri, Forente stater, 63110
        • Saint Louis University Cancer Center
      • Springfield, Missouri, Forente stater, 65802
        • CCOP - Cancer Research for the Ozarks
      • Springfield, Missouri, Forente stater, 65804
        • St. John's Regional Health Center
      • Springfield, Missouri, Forente stater, 65807
        • Hulston Cancer Center at Cox Medical Center South
    • Montana
      • Billings, Montana, Forente stater, 59101
        • CCOP - Montana Cancer Consortium
      • Billings, Montana, Forente stater, 59101
        • St. Vincent Healthcare Cancer Care Services
      • Billings, Montana, Forente stater, 59107-7000
        • Billings Clinic - Downtown
      • Billings, Montana, Forente stater, 59102
        • Hematology-Oncology Centers of the Northern Rockies - Billings
      • Bozeman, Montana, Forente stater, 59715
        • Bozeman Deaconess Cancer Center
      • Butte, Montana, Forente stater, 59701
        • St. James Healthcare Cancer Care
      • Great Falls, Montana, Forente stater, 59405
        • Great Falls Clinic - Main Facility
      • Great Falls, Montana, Forente stater, 59405-5309
        • Big Sky Oncology
      • Great Falls, Montana, Forente stater, 59405
        • Sletten Cancer Institute at Benefis Healthcare
      • Helena, Montana, Forente stater, 59601
        • St. Peter's Hospital
      • Kalispell, Montana, Forente stater, 59901
        • Kalispell Regional Medical Center
      • Kalispell, Montana, Forente stater, 59901
        • Glacier Oncology, PLLC
      • Kalispell, Montana, Forente stater, 59901
        • Kalispell Medical Oncology at KRMC
      • Missoula, Montana, Forente stater, 59807-7877
        • Montana Cancer Specialists at Montana Cancer Center
      • Missoula, Montana, Forente stater, 59807
        • Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
    • Nebraska
      • Lincoln, Nebraska, Forente stater, 68510
        • Cancer Resource Center - Lincoln
      • Omaha, Nebraska, Forente stater, 68106
        • CCOP - Missouri Valley Cancer Consortium
      • Omaha, Nebraska, Forente stater, 68122
        • Immanuel Medical Center
      • Omaha, Nebraska, Forente stater, 68124
        • Alegant Health Cancer Center at Bergan Mercy Medical Center
      • Omaha, Nebraska, Forente stater, 68131-2197
        • Creighton University Medical Center
      • Omaha, Nebraska, Forente stater, 68114
        • Methodist Estabrook Cancer Center
      • Omaha, Nebraska, Forente stater, 68130
        • Lakeside Hospital
    • Nevada
      • Las Vegas, Nevada, Forente stater, 89102
        • University Medical Center of Southern Nevada
      • Las Vegas, Nevada, Forente stater, 89106
        • CCOP - Nevada Cancer Research Foundation
    • New Hampshire
      • Concord, New Hampshire, Forente stater, 03301
        • New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care
      • Exeter, New Hampshire, Forente stater, 03833
        • Center for Cancer Care at Exeter Hospital
      • Hooksett, New Hampshire, Forente stater, 03106
        • New Hampshire Oncology - Hematology, PA - Hooksett
      • Laconia, New Hampshire, Forente stater, 03246
        • Lakes Region General Hospital
    • New Jersey
      • Flemington, New Jersey, Forente stater, 08822
        • Hunterdon Regional Cancer Center at Hunterdon Medical Center
      • Hackensack, New Jersey, Forente stater, 07601
        • CCOP - Northern New Jersey
      • Livingston, New Jersey, Forente stater, 07039
        • St. Barnabas Medical Center Cancer Center
      • Long Branch, New Jersey, Forente stater, 07740-6395
        • Monmouth Medical Center
      • Marlton, New Jersey, Forente stater, 08053
        • Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
      • Newark, New Jersey, Forente stater, 07112
        • Newark Beth Israel Medical Center
      • Pennington, New Jersey, Forente stater, 08534
        • Capital Health Regional Cancer Center
      • Somerville, New Jersey, Forente stater, 08876
        • Somerset Medical Center
      • Sparta, New Jersey, Forente stater, 07871
        • Frederick R. and Betty M. Smith Cancer Treatment Center
      • Toms River, New Jersey, Forente stater, 08755
        • J. Phillip Citta Regional Cancer Center at Community Medical Center
      • Vineland, New Jersey, Forente stater, 08360
        • Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare
      • Voorhees, New Jersey, Forente stater, 08043
        • Cancer Institute of New Jersey at Cooper - Voorhees
      • Voorhees, New Jersey, Forente stater, 08043
        • Fox Chase Virtua Health Cancer Program at Virtua West Jersey
    • New Mexico
      • Albuquerque, New Mexico, Forente stater, 87131-5636
        • University of New Mexico Cancer Center
      • Albuquerque, New Mexico, Forente stater, 87106
        • Hematology Oncology Associates, PC
      • Albuquerque, New Mexico, Forente stater, 87102
        • Lovelace Medical Center - Downtown
    • New York
      • Buffalo, New York, Forente stater, 14215
        • Veterans Affairs Medical Center - Buffalo
      • East Syracuse, New York, Forente stater, 13057
        • CCOP - Hematology-Oncology Associates of Central New York
      • Elmhurst, New York, Forente stater, 11373
        • Elmhurst Hospital Center
      • Jamaica, New York, Forente stater, 11432
        • Queens Cancer Center of Queens Hospital
      • Lake Success, New York, Forente stater, 11042
        • Monter Cancer Center of the North Shore-LIJ Health System
      • Manhasset, New York, Forente stater, 11030
        • CCOP - North Shore University Hospital
      • Manhasset, New York, Forente stater, 11030
        • Don Monti Comprehensive Cancer Center at North Shore University Hospital
      • Middletown, New York, Forente stater, 10940-4199
        • Tucker Center for Cancer Care at Orange Regional Medical Center
      • New Hyde Park, New York, Forente stater, 11040
        • Long Island Jewish Medical Center
      • Staten Island, New York, Forente stater, 10305
        • Nalitt Cancer Institute at Staten Island University Hospital
      • Syracuse, New York, Forente stater, 13210
        • SUNY Upstate Medical University Hospital
    • North Carolina
      • Asheboro, North Carolina, Forente stater, 27203-5400
        • Randolph Hospital
      • Asheville, North Carolina, Forente stater, 28801
        • Mission Hospitals - Memorial Campus
      • Burlington, North Carolina, Forente stater, 27216
        • Alamance Cancer Center at Alamance Regional Medical Center
      • Charlotte, North Carolina, Forente stater, 28232-2861
        • Blumenthal Cancer Center at Carolinas Medical Center
      • Goldsboro, North Carolina, Forente stater, 27534
        • Wayne Memorial Hospital, Incorporated
      • Greensboro, North Carolina, Forente stater, 27403-1198
        • Moses Cone Regional Cancer Center at Wesley Long Community Hospital
      • Hendersonville, North Carolina, Forente stater, 28791
        • Pardee Memorial Hospital
      • Kinston, North Carolina, Forente stater, 28501
        • Kinston Medical Specialists
      • Pinehurst, North Carolina, Forente stater, 28374
        • FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center
      • Reidsville, North Carolina, Forente stater, 27320
        • Annie Penn Cancer Center
      • Rutherfordton, North Carolina, Forente stater, 28139
        • Rutherford Hospital
      • Statesville, North Carolina, Forente stater, 28677
        • Iredell Memorial Hospital
      • Winston-Salem, North Carolina, Forente stater, 27103
        • Forsyth Regional Cancer Center at Forsyth Medical Center
    • North Dakota
      • Bismarck, North Dakota, Forente stater, 58501
        • Medcenter One Hospital Cancer Care Center
      • Bismarck, North Dakota, Forente stater, 58501
        • Mid Dakota Clinic, PC
      • Bismarck, North Dakota, Forente stater, 58502
        • St. Alexius Medical Center Cancer Center
      • Fargo, North Dakota, Forente stater, 58103
        • Dakota Cancer Institute at Dakota Clinic - South University
      • Grand Forks, North Dakota, Forente stater, 58201
        • Altru Cancer Center at Altru Hospital
      • Minot, North Dakota, Forente stater, 58701
        • Trinity CancerCare Center
    • Ohio
      • Akron, Ohio, Forente stater, 44307
        • McDowell Cancer Center at Akron General Medical Center
      • Akron, Ohio, Forente stater, 44309-2090
        • Summa Center for Cancer Care at Akron City Hospital
      • Canton, Ohio, Forente stater, 44710-1799
        • Aultman Cancer Center at Aultman Hospital
      • Canton, Ohio, Forente stater, 44708
        • Mercy Cancer Center at Mercy Medical Center
      • Chillicothe, Ohio, Forente stater, 45601
        • Adena Regional Medical Center
      • Cincinnati, Ohio, Forente stater, 45267
        • Charles M. Barrett Cancer Center at University Hospital
      • Cincinnati, Ohio, Forente stater, 45219
        • Christ Hospital Cancer Center
      • Columbus, Ohio, Forente stater, 43214-3998
        • Riverside Methodist Hospital Cancer Care
      • Columbus, Ohio, Forente stater, 43222
        • Mount Carmel Health - West Hospital
      • Columbus, Ohio, Forente stater, 43215
        • CCOP - Columbus
      • Columbus, Ohio, Forente stater, 43215
        • Grant Medical Center Cancer Care
      • Columbus, Ohio, Forente stater, 43228
        • Doctors Hospital at Ohio Health
      • Dayton, Ohio, Forente stater, 45405
        • Grandview Hospital
      • Dayton, Ohio, Forente stater, 45406
        • Good Samaritan Hospital
      • Dayton, Ohio, Forente stater, 45409
        • David L. Rike Cancer Center at Miami Valley Hospital
      • Dayton, Ohio, Forente stater, 45415
        • Samaritan North Cancer Care Center
      • Dayton, Ohio, Forente stater, 45420
        • CCOP - Dayton
      • Delaware, Ohio, Forente stater, 43015
        • Grady Memorial Hospital
      • Findlay, Ohio, Forente stater, 45840
        • Blanchard Valley Medical Associates
      • Franklin, Ohio, Forente stater, 45005-1066
        • Middletown Regional Hospital
      • Greenville, Ohio, Forente stater, 45331
        • Wayne Hospital
      • Kettering, Ohio, Forente stater, 45429
        • Charles F. Kettering Memorial Hospital
      • Lancaster, Ohio, Forente stater, 43130
        • Fairfield Medical Center
      • Lima, Ohio, Forente stater, 45801
        • St. Rita's Medical Center
      • Marietta, Ohio, Forente stater, 45750
        • Strecker Cancer Center at Marietta Memorial Hospital
      • Mount Vernon, Ohio, Forente stater, 43050
        • Knox Community Hospital
      • Newark, Ohio, Forente stater, 43055
        • Licking Memorial Cancer Care Program at Licking Memorial Hospital
      • Springfield, Ohio, Forente stater, 45505
        • Community Hospital of Springfield and Clark County
      • Troy, Ohio, Forente stater, 45373-1300
        • UVMC Cancer Care Center at Upper Valley Medical Center
      • Westerville, Ohio, Forente stater, 43081
        • Mount Carmel St. Ann's Cancer Center
      • Wright-Patterson Air Force Base, Ohio, Forente stater, 45433-5529
        • United States Air Force Medical Center - Wright-Patterson
      • Xenia, Ohio, Forente stater, 45385
        • Ruth G. McMillan Cancer Center at Greene Memorial Hospital
      • Zanesville, Ohio, Forente stater, 43701
        • Genesis - Good Samaritan Hospital
    • Oklahoma
      • Norman, Oklahoma, Forente stater, 73071
        • Cancer Care Associates - Norman
      • Oklahoma City, Oklahoma, Forente stater, 73120
        • Cancer Care Associates - Mercy Campus
      • Tulsa, Oklahoma, Forente stater, 74136
        • Natalie Warren Bryant Cancer Center at St. Francis Hospital
    • Oregon
      • Clackamas, Oregon, Forente stater, 97015
        • Clackamas Radiation Oncology Center
      • Milwaukie, Oregon, Forente stater, 97222
        • Providence Milwaukie Hospital
      • Newberg, Oregon, Forente stater, 97132
        • Providence Newberg Medical Center
      • Oregon City, Oregon, Forente stater, 97045
        • Willamette Falls Hospital
      • Portland, Oregon, Forente stater, 97213-2967
        • Providence Cancer Center at Providence Portland Medical Center
      • Portland, Oregon, Forente stater, 97225
        • CCOP - Columbia River Oncology Program
      • Portland, Oregon, Forente stater, 97225
        • Providence St. Vincent Medical Center
      • Portland, Oregon, Forente stater, 97227
        • Kaiser Permanente Health Care - Portland
      • Salem, Oregon, Forente stater, 97309-5014
        • Salem Hospital Regional Cancer Care Services
      • The Dalles, Oregon, Forente stater, 97058
        • Celilo Cancer Center at Mid-Columbia Medical Center
    • Pennsylvania
      • Abington, Pennsylvania, Forente stater, 19001
        • Rosenfeld Cancer Center at Abington Memorial Hospital
      • Allentown, Pennsylvania, Forente stater, 18105
        • Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
      • Bethlehem, Pennsylvania, Forente stater, 18017
        • Lehigh Valley Hospital - Muhlenberg
      • Danville, Pennsylvania, Forente stater, 17822-0001
        • Geisinger Cancer Institute at Geisinger Health
      • Darby, Pennsylvania, Forente stater, 19023
        • Mercy Fitzgerald Hospital
      • Doylestown, Pennsylvania, Forente stater, 18901
        • Doylestown Hospital Cancer Center
      • Drexel Hill, Pennsylvania, Forente stater, 19026
        • Delaware County Regional Cancer Center at Delaware County Memorial Hospital
      • DuBois, Pennsylvania, Forente stater, 15801
        • Oncology Hematology Associates of Northern Pennsylvania, PC at Hahne Regional Cancer Center
      • East Stroudsburg, Pennsylvania, Forente stater, 18301
        • Dale and Frances Hughes Cancer Center at Pocono Medical Center
      • Ephrata, Pennsylvania, Forente stater, 17522
        • Ephrata Cancer Center at Ephrata Community Hospital
      • Gettysburg, Pennsylvania, Forente stater, 17325
        • Adams Cancer Center
      • Hanover, Pennsylvania, Forente stater, 17331
        • Cherry Tree Cancer Center
      • Harrisburg, Pennsylvania, Forente stater, 17110-2098
        • PinnacleHealth Regional Cancer Center at Polyclinic Hospital
      • Hazleton, Pennsylvania, Forente stater, 18201
        • Geisinger Hazleton Cancer Center
      • Media, Pennsylvania, Forente stater, 19063
        • Riddle Memorial Hospital Cancer Center
      • Monroeville, Pennsylvania, Forente stater, 15146
        • Forbes Regional Hospital
      • Philadelphia, Pennsylvania, Forente stater, 19107-5541
        • Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
      • Pittsburgh, Pennsylvania, Forente stater, 15212
        • Allegheny Cancer Center at Allegheny General Hospital
      • Pittsburgh, Pennsylvania, Forente stater, 15224-1791
        • Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital
      • Pottstown, Pennsylvania, Forente stater, 19464
        • Pottstown Memorial Regional Cancer Center
      • Scranton, Pennsylvania, Forente stater, 18501
        • Mercy Hospital Cancer Center - Scranton
      • Scranton, Pennsylvania, Forente stater, 18510
        • Hematology and Oncology Associates of Northeastern Pennsylvania
      • State College, Pennsylvania, Forente stater, 16801
        • Geisinger Medical Group - Scenery Park
      • Upland, Pennsylvania, Forente stater, 19013
        • Associates in Hematology-Oncology, PC at Crozer Regional Cancer Center
      • West Grove, Pennsylvania, Forente stater, 19390-9499
        • Jennersville Regional Hospital
      • Wilkes-Barre, Pennsylvania, Forente stater, 18711
        • Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
      • Williamsport, Pennsylvania, Forente stater, 17701
        • Susquehanna Cancer Center at Divine Providence Hospital
      • York, Pennsylvania, Forente stater, 17405
        • York Cancer Center at Apple Hill Medical Center
    • South Carolina
      • Anderson, South Carolina, Forente stater, 29621
        • AnMed Cancer Center
      • Charleston, South Carolina, Forente stater, 29425
        • Hollings Cancer Center at Medical University of South Carolina
      • Charleston, South Carolina, Forente stater, 29401
        • Roper St. Francis Cancer Center at Roper Hospital
      • Florence, South Carolina, Forente stater, 29501
        • McLeod Regional Medical Center
      • Greenville, South Carolina, Forente stater, 29615
        • CCOP - Greenville
      • Greenville, South Carolina, Forente stater, 29605
        • Greenville Hospital Cancer Center
      • Greenville, South Carolina, Forente stater, 29605
        • Cancer Centers of the Carolinas - Faris Road
      • Greenville, South Carolina, Forente stater, 29605
        • Cancer Centers of the Carolinas - Grove Commons
      • Greenville, South Carolina, Forente stater, 29601
        • Bon Secours St. Francis Health System
      • Greer, South Carolina, Forente stater, 29650
        • Cancer Centers of the Carolinas - Greer Medical Oncology
      • Seneca, South Carolina, Forente stater, 29672
        • Cancer Centers of the Carolinas - Seneca
      • Spartanburg, South Carolina, Forente stater, 29303
        • CCOP - Upstate Carolina
      • Spartanburg, South Carolina, Forente stater, 29303
        • Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
      • Spartanburg, South Carolina, Forente stater, 29307
        • Cancer Centers of the Carolinas - Spartanburg
    • South Dakota
      • Aberdeen, South Dakota, Forente stater, 57401
        • Oncology Services of Aberdeen
      • Rapid City, South Dakota, Forente stater, 57701
        • Rapid City Regional Hospital
      • Sioux Falls, South Dakota, Forente stater, 57105
        • Avera Cancer Institute
      • Sioux Falls, South Dakota, Forente stater, 57117-5039
        • Sanford Cancer Center at Sanford USD Medical Center
    • Tennessee
      • Kingsport, Tennessee, Forente stater, 37662
        • Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center
      • Knoxville, Tennessee, Forente stater, 37916
        • Thompson Cancer Survival Center
    • Texas
      • Houston, Texas, Forente stater, 77030-4009
        • M. D. Anderson Cancer Center at University of Texas
      • Laredo, Texas, Forente stater, 78045
        • Doctor's Hospital of Laredo
      • Lubbock, Texas, Forente stater, 79410-1894
        • Joe Arrington Cancer Research and Treatment Center
      • San Antonio, Texas, Forente stater, 78229-3900
        • University of Texas Health Science Center at San Antonio
    • Utah
      • American Fork, Utah, Forente stater, 84003
        • American Fork Hospital
      • Cedar City, Utah, Forente stater, 84720
        • Sandra L. Maxwell Cancer Center
      • Logan, Utah, Forente stater, 84321
        • Logan Regional Hospital
      • Murray, Utah, Forente stater, 84157
        • Jon and Karen Huntsman Cancer Center at Intermountain Medical Center
      • Ogden, Utah, Forente stater, 84403
        • Val and Ann Browning Cancer Center at McKay-Dee Hospital Center
      • Provo, Utah, Forente stater, 84604
        • Utah Valley Regional Medical Center - Provo
      • Saint George, Utah, Forente stater, 84770
        • Dixie Regional Medical Center - East Campus
      • Salt Lake City, Utah, Forente stater, 84143
        • LDS Hospital
      • Salt Lake City, Utah, Forente stater, 84106
        • Utah Cancer Specialists at UCS Cancer Center
    • Virginia
      • Fairfax, Virginia, Forente stater, 22033
        • Kaiser Permanente Medical Center - Fair Oaks
      • McLean, Virginia, Forente stater, 22102
        • Kaiser Permanente Tysons Corner Medical Center
      • Norton, Virginia, Forente stater, 24273
        • Southwest Virginia Regional Cancer Center at Wellmonth Health
      • Richmond, Virginia, Forente stater, 23298-0037
        • Virginia Commonwealth University Massey Cancer Center
    • Washington
      • Bellevue, Washington, Forente stater, 98004
        • Overlake Cancer Center at Overlake Hospital Medical Center
      • Bellingham, Washington, Forente stater, 98225
        • St. Joseph Cancer Center
      • Bremerton, Washington, Forente stater, 98310
        • Olympic Hematology and Oncology
      • Centralia, Washington, Forente stater, 98531-9027
        • Providence Centralia Hospital
      • Everett, Washington, Forente stater, 98201
        • Providence Regional Cancer Partnership
      • Federal Way, Washington, Forente stater, 98003
        • St. Francis Hospital
      • Mount Vernon, Washington, Forente stater, 98274
        • Skagit Valley Hospital Cancer Care Center
      • Olympia, Washington, Forente stater, 98506-5166
        • Providence St. Peter Hospital Regional Cancer Center
      • Puyallup, Washington, Forente stater, 98372
        • Good Samaritan Cancer Center
      • Seattle, Washington, Forente stater, 98109
        • Fred Hutchinson Cancer Research Center
      • Seattle, Washington, Forente stater, 98112
        • Group Health Central Hospital
      • Seattle, Washington, Forente stater, 98122-4307
        • Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
      • Sequim, Washington, Forente stater, 98382
        • Olympic Medical Cancer Center
      • Spokane, Washington, Forente stater, 99204-2967
        • Rockwood Clinic Cancer Treatment Center
      • Tacoma, Washington, Forente stater, 98405-3004
        • Franciscan Cancer Center at St. Joseph Medical Center
      • Tacoma, Washington, Forente stater, 98405
        • Allenmore Hospital
      • Tacoma, Washington, Forente stater, 98405
        • CCOP - Northwest
      • Tacoma, Washington, Forente stater, 98405
        • MultiCare Regional Cancer Center at Tacoma General Hospital
      • Tacoma, Washington, Forente stater, 98499
        • St. Clare Hospital
      • Vancouver, Washington, Forente stater, 98664
        • Southwest Washington Medical Center Cancer Center
      • Walla Walla, Washington, Forente stater, 99362
        • St. Mary Regional Cancer Center at St. Mary Medical Center
      • Wenatchee, Washington, Forente stater, 98801-2028
        • Wenatchee Valley Medical Center
    • West Virginia
      • Clarksburg, West Virginia, Forente stater, 26301
        • United Hospital Center
      • Huntington, West Virginia, Forente stater, 25702
        • St. Mary's Regional Cancer Center at St. Mary's Medical Center
      • Princeton, West Virginia, Forente stater, 24740
        • Princeton Community Hospital
    • Wisconsin
      • Antigo, Wisconsin, Forente stater, 54409
        • Langlade Memorial Hospital
      • Green Bay, Wisconsin, Forente stater, 54301
        • Bellin Memorial Hospital
      • Green Bay, Wisconsin, Forente stater, 54307-3508
        • St. Vincent Hospital Regional Cancer Center
      • Green Bay, Wisconsin, Forente stater, 54301-3526
        • Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
      • Green Bay, Wisconsin, Forente stater, 54303
        • Green Bay Oncology, Limited at St. Mary's Hospital
      • Green Bay, Wisconsin, Forente stater, 54303
        • St. Mary's Hospital Medical Center - Green Bay
      • Janesville, Wisconsin, Forente stater, 53547
        • Mercy Regional Cancer Center
      • Madison, Wisconsin, Forente stater, 53717
        • Dean Medical Center - Madison
      • Manitowoc, Wisconsin, Forente stater, 54221-1450
        • Holy Family Memorial Medical Center Cancer Care Center
      • Marinette, Wisconsin, Forente stater, 54143
        • Bay Area Cancer Care Center at Bay Area Medical Center
      • Marshfield, Wisconsin, Forente stater, 54449
        • Marshfield Clinic - Marshfield Center
      • Mukwonago, Wisconsin, Forente stater, 53149
        • D.N. Greenwald Center
      • Oconomowoc, Wisconsin, Forente stater, 53066
        • Regional Cancer Center at Oconomowoc Memorial Hospital
      • Oconto Falls, Wisconsin, Forente stater, 54154
        • Green Bay Oncology, Limited - Oconto Falls
      • Rice Lake, Wisconsin, Forente stater, 54868
        • Marshfield Clinic - Indianhead Center
      • Sheboygan, Wisconsin, Forente stater, 53081
        • St. Nicholas Hospital
      • Sturgeon Bay, Wisconsin, Forente stater, 54235
        • Green Bay Oncology, Limited - Sturgeon Bay
      • Waukesha, Wisconsin, Forente stater, 53188
        • Waukesha Memorial Hospital Regional Cancer Center
      • Wausau, Wisconsin, Forente stater, 54401
        • University of Wisconcin Cancer Center at Aspirus Wausau Hospital
      • Wisconsin Rapids, Wisconsin, Forente stater, 54494
        • Riverview UW Cancer Center at Riverview Hospital
    • Wyoming
      • Casper, Wyoming, Forente stater, 82609
        • Rocky Mountain Oncology

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

18 år og eldre (Voksen, Eldre voksen)

Tar imot friske frivillige

Nei

Beskrivelse

Inklusjonskriterier

  • Pasienter må ha ytelsesstatus for Eastern Cooperative Oncology Group (ECOG) på 0 eller 1.
  • Pasienter må ha evnen til å svelge orale medisiner.
  • Pasienter må ha resekert adenokarsinom i tykktarmen iscenesatt som American Joint Committee on Cancer (AJCC) stadium 0, I, II eller III.
  • Pasienter må ha hatt kirurgisk reseksjon av colon adenokarsinom med kurativ hensikt innen 1 år før randomisering. (Laparoskopisk assistert kolektomi er tillatt.)
  • Pasienter må ha fullført eventuell adjuvant behandling før randomisering.
  • Pasienter som tar kardiobeskyttende lavdose acetylsalisylsyre ved start i studien må ikke ha klinisk signifikant toksisitet, som bestemt av etterforskeren, som utelukker fortsettelse av aspirin, og pasienten må være villig til å fortsette aspirinbehandling (81 mg eller 325 mg) gjennom hele studien terapi.
  • Krav til koloskopi innen 180 dager før randomisering:
  • Pasienten må enten ha gjennomgått en preoperativ eller postoperativ dokumentert koloskopi til blindtarmen (eller tynntarmsanastomose) med adekvat tarmforberedelse.
  • Alle observerte polypper skal ha blitt fjernet. (Polypper kan fjernes under koloskopi eller kirurgi utført før randomisering.)
  • Postoperativ serumkreatinin utført innen 90 dager før randomisering må være mindre enn eller lik 1,5 x øvre normalgrense (ULN) for laboratoriet.
  • Følgende kriterier for bevis på adekvat leverfunksjon basert på postoperativ testing utført innen 90 dager før randomisering må oppfylles: aspartataminotransferase (AST) eller alaninaminotransferase (ALT) mindre enn eller lik 3,0 x ULN for laboratoriet, og total bilirubin mindre enn eller lik 1,5 x ULN for laboratoriet

Eksklusjonskriterier

  • Tumor med den distale grensen lokalisert mindre enn 12 cm fra analkanten.
  • Total kolektomi eller total proktokolektomi.
  • Klassisk familiær adenomatøs polypose, attenuert familiær adenomatøs polypose (dvs. 20 eller flere adenomer, enten synkrone eller metakrone), eller arvelig ikke-polypose kolorektal kreft (Lynch-syndrom).
  • Malabsorpsjonssyndrom, ulcerøs kolitt, inflammatorisk tarmsykdom, reseksjon av mage eller tynntarm, eller annen sykdom som signifikant påvirker gastrointestinal funksjon.
  • Anamnese med dokumentert øvre GI-blødning eller øvre GI ulcerøs sykdom.
  • Statinbruk innen 30 dager før randomisering.
  • Hyperlipidemi med klinisk indikasjon for statinbehandling eller annen foreskrevet medisin. Bestemmelse av akseptable fastende lipidverdier, innen 90 dager før randomisering, bør være i samsvar med gjeldende retningslinjer for behandling av dyslipidemi.
  • Uvillighet til å avbryte kronisk bruk av ikke-steroide antiinflammatoriske legemidler (NSAIDs) (annet enn kardiobeskyttende lavdose aspirin 81 mg eller 325 mg) før randomisering.
  • Forventet behov for kronisk bruk av NSAIDs (annet enn kardiobeskyttende lavdose aspirin 81 mg eller 325 mg).
  • Utilstrekkelig behandlet hypotyreose, som bestemt av etterforskeren.
  • Anamnese med myopati eller rabdomyolyse.
  • Overfølsomhet eller intoleranse overfor statiner.
  • Kronisk medikamentell behandling med ciklosporin, kumarinantikoagulanter, gemfibrozil, noen andre lipidsenkende terapier (fibrater eller niacin), lopinavir/ritonavir eller medikamenter (som ketokonazol, spironolakton eller cimetidin) som senker nivåer eller aktivitet av steroidhormoner.
  • Graviditet eller amming ved studiestart. (Graviditetstesting må utføres innen 14 dager før randomisering i henhold til institusjonelle standarder for kvinner i fertil alder.)
  • Tidligere maligniteter med mindre pasienten har vært sykdomsfri i 5 eller flere år før randomisering og av legen anses å ha lav risiko for tilbakefall. Pasienter med følgende kreftformer er kvalifisert hvis de er diagnostisert og behandlet i løpet av de siste 5 årene: alle in situ kreftformer og basalcelle- og plateepitelkarsinom i huden.
  • Annen ikke-malign systemisk sykdom som vil hindre en pasient fra å få rosuvastatin eller som vil forhindre forlenget oppfølging.
  • Administrering av ethvert undersøkelsesmiddel innen 30 dager før randomisering.

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

  • Primært formål: Behandling
  • Tildeling: Randomisert
  • Intervensjonsmodell: Parallell tildeling
  • Masking: Firemannsrom

Våpen og intervensjoner

Deltakergruppe / Arm
Intervensjon / Behandling
Placebo komparator: Gruppe 1: placebo
Pasienter får oral placebo én gang daglig i 5 år.
Annen: placebo
Eksperimentell: Gruppe 2: rosuvastatin
Pasienter får oralt rosuvastatin én gang daglig i 5 år.
Legemiddel: rosuvastatin
Andre navn:
  • Crestor

Hva måler studien?

Primære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Forekomst av ≥ 1 adenomatøs polypp i tykktarmen eller rektum, metakront kolorektalt karsinom eller tilbakefall av tykktarmskreft (APMC+R)
Tidsramme: Inntil 4,8 år
Prosentandel av pasienter med forekomst av APMC+R-hendelse. APMC+R-hendelser inkluderer minst én adenomatøs polypp i tykktarmen eller endetarmen, metakront kolorektalt karsinom eller residiv av tykktarmskreft
Inntil 4,8 år

Sekundære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Størrelsen på kolorektale adenomer, inkludert avanserte adenomer
Tidsramme: Inntil 4,8 år
Den histologiske størrelsen (diameter av adenom inn i veggen av tykktarmen; i henhold til AJCC-stadie) av det største adenomet blant pasienter som har minst ett adenom påvist. Hvis histologisk størrelse ikke var tilgjengelig, ble den endoskopiske størrelsen oppgitt.
Inntil 4,8 år
Sykdomsfri overlevelse
Tidsramme: Inntil 4,8 år
Antall pasienter med DFS-hendelse (residiv av tykktarmskreft, andre primære kreft eller død uansett årsak)
Inntil 4,8 år
Total overlevelse (OS)
Tidsramme: Inntil 4,8 år
Antall pasienter med OS-hendelsen (død uansett årsak)
Inntil 4,8 år
Gjentaksfritt intervall (RFI)
Tidsramme: Inntil 4,8 år
Antall pasienter med RFI-hendelsen (første tilbakefall av tykktarmskreft)
Inntil 4,8 år
Andre ikke-kolorektal primær kreftfri intervall
Tidsramme: Inntil 4,8 år
Antall pasienter med første forekomst av ikke-kolorektal primærkreft
Inntil 4,8 år
Atferds- og helseresultater målt ved SF-12-komponentpoeng, global livskvalitetsskala og symptomsjekkliste
Tidsramme: 12 måneders tidspunkt
Global Quality-of-Life Scale-score, varierer fra 0 (dårligst tenkelige helsestatus) til 10 (best tenkelige helsestatus.
12 måneders tidspunkt
Toksisitet vurdert av uønskede hendelser
Tidsramme: Inntil 4,8 år
Andel av pasienter med minst én grad 2 eller høyere bivirkning rapportert.
Inntil 4,8 år
Målinger av relevante tumor- og blodmarkører
Tidsramme: Ved randomisering
Denne studien ble avsluttet tidlig. Data om prøver ble ikke samlet inn, de relevante analysene ble ikke utført.
Ved randomisering

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

NSABP Foundation Inc

Samarbeidspartnere

National Cancer Institute (NCI)

Etterforskere

  • Hovedetterforsker: Norman Wolmark, MD, NSABP Foundation Inc

Publikasjoner og nyttige lenker

Den som er ansvarlig for å legge inn informasjon om studien leverer frivillig disse publikasjonene. Disse kan handle om alt relatert til studiet.

Generelle publikasjoner

  • Boman BM, Bandos H, Wickerham DL, et al.: Statin polyp prevention trial in patients with resected colon cancer: NSABP protocol P-5. [Abstract] J Clin Oncol 30 (Suppl 15): A-TPS1615, 2012.

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart

1. mars 2010

Primær fullføring (Faktiske)

1. desember 2014

Studiet fullført (Faktiske)

1. februar 2015

Datoer for studieregistrering

Først innsendt

10. november 2009

Først innsendt som oppfylte QC-kriteriene

10. november 2009

Først lagt ut (Antatt)

11. november 2009

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

16. august 2023

Siste oppdatering sendt inn som oppfylte QC-kriteriene

27. juli 2023

Sist bekreftet

1. juli 2023

Mer informasjon

Begreper knyttet til denne studien

Nøkkelord

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

  • NSABP-P-5
  • NSABP P-5
  • NCI-2011-09183 (Registeridentifikator: CTRP (Clinical Trials Reporting Program))

Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .

Abonnere