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Undersøgelse for at evaluere effekten af fluticasonfuroat/vilanterol på overlevelse hos personer med kronisk obstruktiv lungesygdom

2. august 2018 opdateret af: GlaxoSmithKline

En undersøgelse af kliniske resultater til sammenligning af virkningen af fluticasonfuroat/vilanterol inhalationspulver 100/25 mcg med placebo på overlevelse hos forsøgspersoner med moderat kronisk obstruktiv lungesygdom (KOL) og en historie med eller med øget risiko for hjerte-kar-sygdomme

Formålet med denne undersøgelse er at bestemme, om fluticasonfuroat/vilanterol forbedrer overlevelsen hos patienter med kronisk obstruktiv lungesygdom med en historie med eller øget risiko for hjertesygdom.

Studieoversigt

Status

Afsluttet

Betingelser

Lungesygdom, kronisk obstruktiv

Intervention / Behandling

Detaljeret beskrivelse

På trods af en potentiel sammenhæng mellem de patogenetiske mekanismer, der er involveret i kronisk obstruktiv lungesygdom (KOL) og aterosklerotisk kardiovaskulær sygdom, er der ingen i øjeblikket godkendte behandlinger til patienter med KOL, som klart har vist en yderligere gavnlig effekt hos patienter med kardiovaskulære komorbiditeter. TOwards a Revolution in COPD Health (TORCH)-undersøgelsen vurderede virkningen af det inhalerede kortikosteroid (ICS) fluticasonpropionat (FP) i kombination med den langtidsvirkende beta-agonist (LABA), salmeterol (SAL), til at reducere dødeligheden af alle årsager . TORCH viste en reduktion på 17,5 % af dødeligheden af alle årsager med salmeterol-fluticasonpropionatkombination (SFC) sammenlignet med placebo (HR=0,825, 95 % CI (0,681, 1,002), p=0,052) i hele KOL-populationen med sygdomssværhedsgrad fra moderat til meget svær. En post hoc-analyse af data begrænset til de forsøgspersoner med et forceret ekspiratorisk volumen på 1 sekund (FEV1) >=50 % forudsagt med en tilsyneladende historie med kardiovaskulære komorbiditeter (defineret som brug ved baseline af betablokkere, angiotensinkonverterende enzym hæmmere (ACEI)/angiotensinreceptorblokkere (ARB), HMG CoA-reduktasehæmmere (dvs. statiner) eller et tidligere hjerteinfarkt registreret ved baseline) viste en 49 % reduktion i risikoen for at dø inden for 96 uger til sammenligning af SFC med placebo. Disse post hoc-data tyder på muligheden for, at et ICS/LABA-kombinationsprodukt kan være til væsentlig fordel hos KOL-patienter med mindre alvorlig luftstrømsobstruktion, men med øget kardiovaskulær risiko.

Den mekanisme, hvorved SFC ser ud til at være forbundet med en større reduktion i dødeligheden hos disse mindre alvorlige KOL-patienter med samtidige kardiovaskulære komorbiditeter, er spekulativ på nuværende tidspunkt, men kan potentielt til dels være relateret til en reduktion af graden af inflammation i det systemiske kredsløb. potentiel plakstabilisering og/eller forbedring af arteriel stivhed.

ICS/LABA-kombinationer, der i øjeblikket er tilgængelige, kræver administration to gange dagligt. En én gang daglig ICS/LABA-kombination har potentialet til at forbedre patientcompliance og som et resultat den overordnede sygdomsbehandling.

Formålet med denne undersøgelse er prospektivt at evaluere effekten af ICS/LABA-kombinationen én gang dagligt Fluticasone Furoat (FF)/Vilanterol (VI) på overlevelse hos forsøgspersoner med moderat KOL (>=50 og =<70 % forudsagt FEV1) og en historie med eller med øget risiko for hjerte-kar-sygdomme.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

16568

Fase

Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Argentina
- - Buenos Aires, Argentina, C1120AAC
    - GSK Investigational Site
  - Buenos Aires, Argentina, C1425FVH
    - GSK Investigational Site
  - Buenos Aires, Argentina, C1280AEB
    - GSK Investigational Site
  - Buenos Aires, Argentina, B1704ETD
    - GSK Investigational Site
  - Buenos Aires, Argentina, C1061ABD
    - GSK Investigational Site
  - Buenos Aires, Argentina, C1407HUF
    - GSK Investigational Site
  - Buenos Aires, Argentina, C1425AGC
    - GSK Investigational Site
  - Buenos Aires, Argentina, C1437BZ
    - GSK Investigational Site
  - Ciudad Autonoma de Buenos Aires, Argentina, C1425BEN
    - GSK Investigational Site
  - Ciudad Autónoma de Buenos Aires, Argentina, C1426ABP
    - GSK Investigational Site
  - Cordoba, Argentina, 5000
    - GSK Investigational Site
  - Cordoba, Argentina, 5016
    - GSK Investigational Site
  - Cordoba, Argentina, 5900
    - GSK Investigational Site
  - Cordoba, Argentina, X5003DCE
    - GSK Investigational Site
  - Cordoba, Argentina, X5004BAL
    - GSK Investigational Site
  - Cordoba, Argentina, X5006
    - GSK Investigational Site
  - Coronel Suarez, Argentina, 7540
    - GSK Investigational Site
  - Corrientes, Argentina, W3400AVK
    - GSK Investigational Site
  - Florencio Varela, Argentina, C1073ABA
    - GSK Investigational Site
  - Formosa, Argentina, 3600
    - GSK Investigational Site
  - Jujuy, Argentina, 4600
    - GSK Investigational Site
  - Lanús, Argentina, B1824KAJ
    - GSK Investigational Site
  - Mar del Plata, Argentina, B7600FYK
    - GSK Investigational Site
  - Mendoza, Argentina, M5500CCG
    - GSK Investigational Site
  - Mendoza, Argentina, 5500
    - GSK Investigational Site
  - Mendoza, Argentina, MM5500
    - GSK Investigational Site
  - Monte Grande, Argentina, 1842
    - GSK Investigational Site
  - Rosario, Argentina, 2000
    - GSK Investigational Site
  - Rosario, Argentina, S2000CXP
    - GSK Investigational Site
  - Salta, Argentina, A4400ERH
    - GSK Investigational Site
  - Salta, Argentina, A4400ANG
    - GSK Investigational Site
  - San Luis, Argentina, 5700
    - GSK Investigational Site
  - San Miguel de Tucuman, Argentina, 4000
    - GSK Investigational Site
  - San Miguel de Tucumán, Argentina, 4000
    - GSK Investigational Site
  - Santa Fe, Argentina, 3000
    - GSK Investigational Site
  - Santa Fe, Argentina, 3016
    - GSK Investigational Site
  - Santiago del Estero, Argentina
    - GSK Investigational Site
- Buenos Aires
  - Adrogue, Buenos Aires, Argentina, B1846DSK
    - GSK Investigational Site
  - Bahia Blanca, Buenos Aires, Argentina, B8000FTD
    - GSK Investigational Site
  - Ciudad Autnónoma de Buenos Aires, Buenos Aires, Argentina, C1186ACB
    - GSK Investigational Site
  - Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1028AAP
    - GSK Investigational Site
  - Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1122AAK
    - GSK Investigational Site
  - Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1405BCH
    - GSK Investigational Site
  - Derqui, Pilar, Buenos Aires, Argentina, B1629AHJ
    - GSK Investigational Site
  - Florencio Varela, Buenos Aires, Argentina, 1888
    - GSK Investigational Site
  - La Plata, Buenos Aires, Argentina, B1900AXI
    - GSK Investigational Site
  - La Plata, Buenos Aires, Argentina, 1900
    - GSK Investigational Site
  - Mar del Plata, Buenos Aires, Argentina, B7600FZN
    - GSK Investigational Site
  - Nueve de Julio, Buenos Aires, Argentina, B6500BWQ
    - GSK Investigational Site
  - Olivos, Buenos Aires, Argentina, B1605DSX
    - GSK Investigational Site
  - Pergamino, Buenos Aires, Argentina, B2700CPM
    - GSK Investigational Site
  - Quilmes, Buenos Aires, Argentina, B1878FNR
    - GSK Investigational Site
  - Quilmes, Buenos Aires, Argentina, 1878
    - GSK Investigational Site
  - San Isidro, Buenos Aires, Argentina, B1642DCD
    - GSK Investigational Site
  - San Martin, Buenos Aires, Argentina, 1650
    - GSK Investigational Site
  - San Nicolas, Buenos Aires, Argentina, B2900DMH
    - GSK Investigational Site
  - San Nicolas, Buenos Aires, Argentina, B2900IIC
    - GSK Investigational Site
  - Vicente López, Buenos Aires, Argentina, 1602
    - GSK Investigational Site
- Córdova
  - Cordoba, Córdova, Argentina, X5000AAW
    - GSK Investigational Site
  - Cordoba, Córdova, Argentina, X5003DCE
    - GSK Investigational Site
- Entre Ríos
  - Concepcion del Uruguay, Entre Ríos, Argentina, 3260
    - GSK Investigational Site
  - Parana, Entre Ríos, Argentina, E3100BHK
    - GSK Investigational Site
- Mendoza
  - Godoy Cruz, Mendoza, Argentina, 5501
    - GSK Investigational Site
- Río Negro
  - Cipoletti, Rio Negro, Río Negro, Argentina, R8324CVE
    - GSK Investigational Site
- Santa Fe
  - Rosario, Santa Fe, Argentina, 2000
    - GSK Investigational Site
  - Rosario, Santa Fe, Argentina, S2000BIF
    - GSK Investigational Site
  - Rosario, Santa Fe, Argentina, S2000CVD
    - GSK Investigational Site
  - Rosario, Santa Fe, Argentina, S2002OJN
    - GSK Investigational Site
  - Rosario, Santa Fe, Argentina, S2005PAF
    - GSK Investigational Site
- Tucumán
  - Tucuman, Tucumán, Argentina, 4000
    - GSK Investigational Site
Australien
- - Glen Osmond, Australien, 5064
    - GSK Investigational Site
- Queensland
  - Cairns, Queensland, Australien, 4870
    - GSK Investigational Site
  - Redcliffe, Queensland, Australien, 4020
    - GSK Investigational Site
- South Australia
  - Bedford Park, South Australia, Australien, 5042
    - GSK Investigational Site
  - Daw Park, South Australia, Australien, 5041
    - GSK Investigational Site
- Victoria
  - Footscray, Victoria, Australien, 3011
    - GSK Investigational Site
  - Geelong, Victoria, Australien, 3220
    - GSK Investigational Site
  - Melbourne, Victoria, Australien, 3004
    - GSK Investigational Site
Belgien
- - Diest, Belgien, 3290
    - GSK Investigational Site
  - Erpent, Belgien, 5101
    - GSK Investigational Site
  - Gilly, Belgien, 6060
    - GSK Investigational Site
  - Mons, Belgien, 7000
    - GSK Investigational Site
  - Namur, Belgien, 5000
    - GSK Investigational Site
Bosnien-Hercegovina
- - Banja Luka, Bosnien-Hercegovina, 78000
    - GSK Investigational Site
  - Banjaluka, Bosnien-Hercegovina, 78000
    - GSK Investigational Site
  - Bihac, Bosnien-Hercegovina, 77 000
    - GSK Investigational Site
  - Bihac, Bosnien-Hercegovina, 77000
    - GSK Investigational Site
  - Bijeljina, Bosnien-Hercegovina, 76300
    - GSK Investigational Site
  - Brcko, Bosnien-Hercegovina, 76000
    - GSK Investigational Site
  - Foca, Bosnien-Hercegovina, 73300
    - GSK Investigational Site
  - Gracanica, Bosnien-Hercegovina, 75320
    - GSK Investigational Site
  - Gradiska, Bosnien-Hercegovina, 78400
    - GSK Investigational Site
  - Istocno Sarajevo, Bosnien-Hercegovina, 71123
    - GSK Investigational Site
  - Konjic, Bosnien-Hercegovina, 88400
    - GSK Investigational Site
  - Mostar, Bosnien-Hercegovina, 88000
    - GSK Investigational Site
  - Novi Travnik, Bosnien-Hercegovina
    - GSK Investigational Site
  - Pale, Bosnien-Hercegovina, 71420
    - GSK Investigational Site
  - Sarajevo, Bosnien-Hercegovina, 71000
    - GSK Investigational Site
  - Sarajevo, Bosnien-Hercegovina, 71320
    - GSK Investigational Site
  - Srebrenik, Bosnien-Hercegovina, 75350
    - GSK Investigational Site
  - Tesanj, Bosnien-Hercegovina, 74260
    - GSK Investigational Site
  - Teslić, Bosnien-Hercegovina, 74270
    - GSK Investigational Site
  - Travnik, Bosnien-Hercegovina, 72270
    - GSK Investigational Site
  - Trebinje, Bosnien-Hercegovina, 89101
    - GSK Investigational Site
  - Tuzla, Bosnien-Hercegovina, 75000
    - GSK Investigational Site
  - Visegrad, Bosnien-Hercegovina, 73240
    - GSK Investigational Site
  - Zenica, Bosnien-Hercegovina, 72000
    - GSK Investigational Site
Bulgarien
- - Blagoevgrad, Bulgarien, 2700
    - GSK Investigational Site
  - Dimitrovgrad, Bulgarien, 6400
    - GSK Investigational Site
  - Gabrovo, Bulgarien, 5300
    - GSK Investigational Site
  - Kozlodui, Bulgarien, 3320
    - GSK Investigational Site
  - Lovech, Bulgarien, 5500
    - GSK Investigational Site
  - Pazardjik, Bulgarien, 4400
    - GSK Investigational Site
  - Petrich, Bulgarien, 2850
    - GSK Investigational Site
  - Pleven, Bulgarien, 5800
    - GSK Investigational Site
  - Plovdiv, Bulgarien, 4002
    - GSK Investigational Site
  - Razgrad, Bulgarien, 7200
    - GSK Investigational Site
  - Rousse, Bulgarien, 7000
    - GSK Investigational Site
  - Sevlievo, Bulgarien, 5400
    - GSK Investigational Site
  - Sliven, Bulgarien, 8800
    - GSK Investigational Site
  - Sofia, Bulgarien, 1431
    - GSK Investigational Site
  - Sofia, Bulgarien, 1606
    - GSK Investigational Site
  - Sofia, Bulgarien, 1233
    - GSK Investigational Site
  - Sofia, Bulgarien, 1000
    - GSK Investigational Site
  - Sofia, Bulgarien, 1202
    - GSK Investigational Site
  - Sofia, Bulgarien, 1784
    - GSK Investigational Site
  - Sofia, Bulgarien, 1336
    - GSK Investigational Site
  - Sofia, Bulgarien, 1505
    - GSK Investigational Site
  - Sofia, Bulgarien, 1142
    - GSK Investigational Site
  - Sofia, Bulgarien, 1618
    - GSK Investigational Site
  - Stara Zagora, Bulgarien, 6000
    - GSK Investigational Site
  - Stara Zagora, Bulgarien, 6003
    - GSK Investigational Site
  - Troyan, Bulgarien, 5600
    - GSK Investigational Site
  - Varna, Bulgarien, 9000
    - GSK Investigational Site
  - Veliko Tarnovo, Bulgarien, 5000
    - GSK Investigational Site
  - Vidin, Bulgarien, 3700
    - GSK Investigational Site
Canada
- - Quebec, Canada, G1G 4A2
    - GSK Investigational Site
- Alberta
  - Edmonton, Alberta, Canada, T5A 4L8
    - GSK Investigational Site
  - Edmonton, Alberta, Canada, T5J 3S9
    - GSK Investigational Site
- British Columbia
  - Kamloops, British Columbia, Canada, V2C 1K7
    - GSK Investigational Site
  - Penticton, British Columbia, Canada, V2A 5C8
    - GSK Investigational Site
  - Vancouver, British Columbia, Canada, V5Z 4E1
    - GSK Investigational Site
  - West Vancouver, British Columbia, Canada, V7T 2Z3
    - GSK Investigational Site
- Manitoba
  - Winnipeg, Manitoba, Canada, R3H 2A6
    - GSK Investigational Site
- Ontario
  - Bolton, Ontario, Canada, L7E 4C8
    - GSK Investigational Site
  - Burlington, Ontario, Canada, L7N 3V2
    - GSK Investigational Site
  - Grimsby, Ontario, Canada, L3M 1P3
    - GSK Investigational Site
  - London, Ontario, Canada, N5Y 5K7
    - GSK Investigational Site
  - Mississauga, Ontario, Canada, L5M 2V8
    - GSK Investigational Site
  - Mississauga, Ontario, Canada, L4T 4J2
    - GSK Investigational Site
  - Newmarket, Ontario, Canada, L3Y 5G8
    - GSK Investigational Site
  - Orleans, Ontario, Canada, K4A 5E6
    - GSK Investigational Site
  - Sarnia, Ontario, Canada, N7T 4X3
    - GSK Investigational Site
  - Toronto, Ontario, Canada, M5T 3A9
    - GSK Investigational Site
  - Windsor, Ontario, Canada, N8X 5A6
    - GSK Investigational Site
- Quebec
  - Mirabel, Quebec, Canada, J7J 2K8
    - GSK Investigational Site
  - Montreal, Quebec, Canada, H2W1T8
    - GSK Investigational Site
  - Sainte Jerome, Quebec, Canada, J7Z 5T3
    - GSK Investigational Site
Chile
- Región De La Araucania
  - Temuco, Región De La Araucania, Chile
    - GSK Investigational Site
  - Temuco, Región De La Araucania, Chile, 4800798
    - GSK Investigational Site
- Región Metro De Santiago
  - Santiago, Región Metro De Santiago, Chile
    - GSK Investigational Site
  - Santiago, Región Metro De Santiago, Chile, 7500691
    - GSK Investigational Site
  - Santiago, Región Metro De Santiago, Chile, 8910131
    - GSK Investigational Site
- Valparaíso
  - Viña del Mar, Valparaíso, Chile, 2340000
    - GSK Investigational Site
Colombia
- - Barranquilla, Colombia
    - GSK Investigational Site
  - Bogota, Colombia
    - GSK Investigational Site
  - Bogota, Colombia, 111211
    - GSK Investigational Site
  - Bogotá, Colombia
    - GSK Investigational Site
  - Bogotá, Colombia, 80CO
    - GSK Investigational Site
  - Cali, Colombia, 571
    - GSK Investigational Site
  - Medellin, Colombia
    - GSK Investigational Site
  - Medellin, Colombia, 80372
    - GSK Investigational Site
  - Zipaquira, Colombia
    - GSK Investigational Site
Den Russiske Føderation
- - Arkhangelsk, Den Russiske Føderation, 163001
    - GSK Investigational Site
  - Arkhangelsk, Den Russiske Føderation, 163061
    - GSK Investigational Site
  - Barnaul, Den Russiske Føderation, 656024
    - GSK Investigational Site
  - Barnaul, Den Russiske Føderation, 656038
    - GSK Investigational Site
  - Chelyabinsk, Den Russiske Føderation, 454021
    - GSK Investigational Site
  - Chelyabinsk, Den Russiske Føderation, 454047
    - GSK Investigational Site
  - Chelyabinsk, Den Russiske Føderation, 454091
    - GSK Investigational Site
  - Ekaterinburg, Den Russiske Føderation, 620137
    - GSK Investigational Site
  - Ekaterinburg, Den Russiske Føderation, 620109
    - GSK Investigational Site
  - Ekaterinburg, Den Russiske Føderation, 620149
    - GSK Investigational Site
  - Gatchina, Den Russiske Føderation, 188300
    - GSK Investigational Site
  - Ivanovo, Den Russiske Føderation, 153462
    - GSK Investigational Site
  - Izhevsk, Den Russiske Føderation, 426063
    - GSK Investigational Site
  - Kaliningrad, Den Russiske Føderation, 236016
    - GSK Investigational Site
  - Kazan, Den Russiske Føderation, 420012
    - GSK Investigational Site
  - Kemerovo, Den Russiske Føderation, 650000
    - GSK Investigational Site
  - Kemerovo, Den Russiske Føderation, 650002
    - GSK Investigational Site
  - Kirov, Den Russiske Føderation, 610027
    - GSK Investigational Site
  - Krasnoyarsk, Den Russiske Føderation, 660022
    - GSK Investigational Site
  - Kursk, Den Russiske Føderation, 305035
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 123182
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 119049
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 117292
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 117997
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 115478
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 119991
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 111539
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 119620
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 121 309
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 127018
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 115 280
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 129301
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 117593
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 105066
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 115093
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 119002
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 125299
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 107392
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 109263
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 111111
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 115432
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 115516
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 115682
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 117630
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 119048
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 119121
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 119229
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 121374
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 123060
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 125205
    - GSK Investigational Site
  - Moscow, Den Russiske Føderation, 129090
    - GSK Investigational Site
  - Nizhniy Novgorod, Den Russiske Føderation, 603035
    - GSK Investigational Site
  - Novosibirsk, Den Russiske Føderation, 630099
    - GSK Investigational Site
  - Novosibirsk, Den Russiske Føderation, 630087
    - GSK Investigational Site
  - Novosibirsk, Den Russiske Føderation, 630091
    - GSK Investigational Site
  - Novosibirsk, Den Russiske Føderation, 630008
    - GSK Investigational Site
  - Novosibirsk, Den Russiske Føderation, 630051
    - GSK Investigational Site
  - Novosibirsk, Den Russiske Føderation, 630075
    - GSK Investigational Site
  - Novosibirsk, Den Russiske Føderation
    - GSK Investigational Site
  - Orenburg, Den Russiske Føderation, 460000
    - GSK Investigational Site
  - Orenburg, Den Russiske Føderation, 460018
    - GSK Investigational Site
  - Perm, Den Russiske Føderation, 614070
    - GSK Investigational Site
  - Perm, Den Russiske Føderation, 614097
    - GSK Investigational Site
  - Perm, Den Russiske Føderation, 614111
    - GSK Investigational Site
  - Pskov, Den Russiske Føderation, 180016
    - GSK Investigational Site
  - Rostov-on-Don, Den Russiske Føderation, 344022
    - GSK Investigational Site
  - Ryazan, Den Russiske Føderation, 390026
    - GSK Investigational Site
  - Ryazan, Den Russiske Føderation, 390039
    - GSK Investigational Site
  - Ryazan, Den Russiske Føderation, 390005
    - GSK Investigational Site
  - Saint Petersburg, Den Russiske Føderation, 192177
    - GSK Investigational Site
  - Saint Petersburg, Den Russiske Føderation, 197022
    - GSK Investigational Site
  - Saint Petersburg, Den Russiske Føderation, 194044
    - GSK Investigational Site
  - Saint Petersburg, Den Russiske Føderation, 195257
    - GSK Investigational Site
  - Saint Petersburg, Den Russiske Føderation, 196084
    - GSK Investigational Site
  - Saint Petersburg, Den Russiske Føderation, 198103
    - GSK Investigational Site
  - Saint-Petersburg, Den Russiske Føderation, 194354
    - GSK Investigational Site
  - Saint-Petersburg, Den Russiske Føderation, 198328
    - GSK Investigational Site
  - Saint-Petersburg, Den Russiske Føderation, 198260
    - GSK Investigational Site
  - Saint-Petersburg, Den Russiske Føderation, 195112
    - GSK Investigational Site
  - Saint-Petersburg, Den Russiske Føderation, 196084
    - GSK Investigational Site
  - Saint-Petersburg, Den Russiske Føderation, 196601
    - GSK Investigational Site
  - Saratov, Den Russiske Føderation, 410028
    - GSK Investigational Site
  - Saratov, Den Russiske Føderation, 410012
    - GSK Investigational Site
  - Saratov, Den Russiske Føderation, 410054
    - GSK Investigational Site
  - Saratov, Den Russiske Føderation, 410018
    - GSK Investigational Site
  - Saratov, Den Russiske Føderation, 410039
    - GSK Investigational Site
  - Sestroretsk, Den Russiske Føderation, 197706
    - GSK Investigational Site
  - Smolensk, Den Russiske Føderation, 214006
    - GSK Investigational Site
  - Smolensk, Den Russiske Føderation, 214 019
    - GSK Investigational Site
  - St Petersburg, Den Russiske Føderation, 192283
    - GSK Investigational Site
  - St Petersburg, Den Russiske Føderation, 194354
    - GSK Investigational Site
  - St'Petersburg, Den Russiske Føderation, 193312
    - GSK Investigational Site
  - St-Petersburg, Den Russiske Føderation, 194017
    - GSK Investigational Site
  - St-Petersburg, Den Russiske Føderation, 193312
    - GSK Investigational Site
  - St-Petersburg, Den Russiske Føderation, 199106
    - GSK Investigational Site
  - St. Petersburg, Den Russiske Føderation, 194356
    - GSK Investigational Site
  - St. Petersburg, Den Russiske Føderation, 197022
    - GSK Investigational Site
  - St. Petersburg, Den Russiske Føderation, 190103
    - GSK Investigational Site
  - St. Petersburg, Den Russiske Føderation, 191015
    - GSK Investigational Site
  - St.Petersburg, Den Russiske Føderation, 191025
    - GSK Investigational Site
  - St.Petersburg, Den Russiske Føderation, 197089
    - GSK Investigational Site
  - St.Рetersburg, Den Russiske Føderation, 198035
    - GSK Investigational Site
  - Tomsk, Den Russiske Føderation, 634063
    - GSK Investigational Site
  - Tomsk, Den Russiske Føderation, 634050
    - GSK Investigational Site
  - Tomsk, Den Russiske Føderation, 634 050
    - GSK Investigational Site
  - Tomsk, Den Russiske Føderation, 634012
    - GSK Investigational Site
  - Tver, Den Russiske Føderation, 170036
    - GSK Investigational Site
  - Ufa, Den Russiske Føderation, 450071
    - GSK Investigational Site
  - Ulyanovsk, Den Russiske Føderation, 432063
    - GSK Investigational Site
  - Voronezh, Den Russiske Føderation, 394066
    - GSK Investigational Site
  - Voronezh, Den Russiske Føderation, 394018
    - GSK Investigational Site
  - Vsevolzhsk, Den Russiske Føderation, 188640
    - GSK Investigational Site
  - Yaroslavl, Den Russiske Føderation, 150003
    - GSK Investigational Site
  - Yaroslavl, Den Russiske Føderation, 150023
    - GSK Investigational Site
  - Yaroslavl, Den Russiske Føderation, 150062
    - GSK Investigational Site
  - Yaroslavl, Den Russiske Føderation, 150010
    - GSK Investigational Site
  - Yaroslavl, Den Russiske Føderation, 150002
    - GSK Investigational Site
Det Forenede Kongerige
- - Bexhill-on-Sea, Det Forenede Kongerige, TN40 1JJ
    - GSK Investigational Site
  - Birmingham, Det Forenede Kongerige, B9 5SS
    - GSK Investigational Site
  - Brighton, Det Forenede Kongerige, BN2 5BE
    - GSK Investigational Site
  - Cardiff, Det Forenede Kongerige, CF14 5GJ
    - GSK Investigational Site
  - Chelmsford, Det Forenede Kongerige, CM1 7ET
    - GSK Investigational Site
  - Derby, Det Forenede Kongerige, DE22 3NE
    - GSK Investigational Site
  - Edgbaston, Birmingham, Det Forenede Kongerige, B15 2SQ
    - GSK Investigational Site
  - Edinburgh, Det Forenede Kongerige, EH16 4SA
    - GSK Investigational Site
  - Glasgow, Det Forenede Kongerige, G20 0SP
    - GSK Investigational Site
  - London, Det Forenede Kongerige, EC1M 6BQ
    - GSK Investigational Site
  - Manchester, Det Forenede Kongerige, M15 6SX
    - GSK Investigational Site
  - Milton Keynes, Det Forenede Kongerige, MK6 5LD
    - GSK Investigational Site
  - Reading, Det Forenede Kongerige, RG2 0TG
    - GSK Investigational Site
  - Sidcup, Kent, Det Forenede Kongerige, DA14 6LT
    - GSK Investigational Site
  - Tyne And Wear, Det Forenede Kongerige, NE29 8NH
    - GSK Investigational Site
- Bedfordshire
  - Bedford, Bedfordshire, Det Forenede Kongerige, MK42 9DJ
    - GSK Investigational Site
  - Bedford, Bedfordshire, Det Forenede Kongerige, MK404AW
    - GSK Investigational Site
- Cambridgeshire
  - Peterborough, Cambridgeshire, Det Forenede Kongerige, PE8 6PL
    - GSK Investigational Site
  - Soham, Cambridgeshire, Det Forenede Kongerige, CB7 5JD
    - GSK Investigational Site
- Derbyshire
  - Chesterfield, Derbyshire, Det Forenede Kongerige, S40 4AA
    - GSK Investigational Site
- Lancashire
  - Buckshaw Village, Chorley, Lancashire, Det Forenede Kongerige, PR7 7NA
    - GSK Investigational Site
- Merseyside
  - Liverpool, Merseyside, Det Forenede Kongerige, L9 7AL
    - GSK Investigational Site
  - Waterloo, Liverpool, Merseyside, Det Forenede Kongerige, L22 0LG
    - GSK Investigational Site
- Middlesex
  - Northwood, Middlesex, Det Forenede Kongerige, HA6 2RN
    - GSK Investigational Site
- Suffolk
  - Bury St Edmunds, Suffolk, Det Forenede Kongerige, IP30 9QU
    - GSK Investigational Site
Filippinerne
- - Alabang, Muntinlupa City, Filippinerne, 1780
    - GSK Investigational Site
  - Caloocan, Filippinerne, 1400
    - GSK Investigational Site
  - Cavite, Filippinerne, 4114
    - GSK Investigational Site
  - Cebu City, Filippinerne, 6000
    - GSK Investigational Site
  - Dasmariñas, Cavite, Filippinerne, 4114
    - GSK Investigational Site
  - Davao, Filippinerne, 8000
    - GSK Investigational Site
  - Iloilo, Filippinerne, 5000
    - GSK Investigational Site
  - Iloilo City, Filippinerne, 5000
    - GSK Investigational Site
  - Jaro, Iloilo City, Filippinerne, 5000
    - GSK Investigational Site
  - Los Banos, Filippinerne, 4030
    - GSK Investigational Site
  - Manila, Filippinerne, 1000
    - GSK Investigational Site
  - Manila, Filippinerne, 1012
    - GSK Investigational Site
  - Marilao, Bulacan, Filippinerne, 3019
    - GSK Investigational Site
  - Pasay, Filippinerne, 1300
    - GSK Investigational Site
  - Pasig, Filippinerne, 1605
    - GSK Investigational Site
  - Quezon, Filippinerne, 1104
    - GSK Investigational Site
  - Quezon City, Filippinerne, 1102
    - GSK Investigational Site
  - Quezon City, Filippinerne, 1100
    - GSK Investigational Site
  - Quezon City, Filippinerne, 1109
    - GSK Investigational Site
  - Quezon City, Filippinerne, 1108
    - GSK Investigational Site
  - San Fernando, Pampanga, Filippinerne, 2000
    - GSK Investigational Site
Forenede Stater
- Alabama
  - Andalusia, Alabama, Forenede Stater, 36420
    - GSK Investigational Site
  - Athens, Alabama, Forenede Stater, 35611
    - GSK Investigational Site
  - Birmingham, Alabama, Forenede Stater, 35209
    - GSK Investigational Site
  - Birmingham, Alabama, Forenede Stater, 35233
    - GSK Investigational Site
  - Birmingham, Alabama, Forenede Stater, 35216
    - GSK Investigational Site
  - Birmingham, Alabama, Forenede Stater, 35242
    - GSK Investigational Site
  - Huntsville, Alabama, Forenede Stater, 35801
    - GSK Investigational Site
  - Huntsville, Alabama, Forenede Stater, 35816
    - GSK Investigational Site
  - Mobile, Alabama, Forenede Stater, 36608
    - GSK Investigational Site
  - Mobile, Alabama, Forenede Stater, 36604
    - GSK Investigational Site
  - Montgomery, Alabama, Forenede Stater, 36106
    - GSK Investigational Site
  - Montgomery, Alabama, Forenede Stater, 36109
    - GSK Investigational Site
  - Muscle Shoals, Alabama, Forenede Stater, 35662
    - GSK Investigational Site
  - Ozark, Alabama, Forenede Stater, 36360
    - GSK Investigational Site
  - Pell City, Alabama, Forenede Stater, 35128
    - GSK Investigational Site
  - Tuscumbia, Alabama, Forenede Stater, 35674
    - GSK Investigational Site
- Arizona
  - Flagstaff, Arizona, Forenede Stater, 86001
    - GSK Investigational Site
  - Glendale, Arizona, Forenede Stater, 85306
    - GSK Investigational Site
  - Phoenix, Arizona, Forenede Stater, 85018
    - GSK Investigational Site
  - Phoenix, Arizona, Forenede Stater, 85032
    - GSK Investigational Site
  - Scottsdale, Arizona, Forenede Stater, 85258
    - GSK Investigational Site
  - Sierra Vista, Arizona, Forenede Stater, 85635
    - GSK Investigational Site
  - Tucson, Arizona, Forenede Stater, 85745
    - GSK Investigational Site
  - Tucson, Arizona, Forenede Stater, 85710
    - GSK Investigational Site
- Arkansas
  - Fayetteville, Arkansas, Forenede Stater, 72703
    - GSK Investigational Site
  - Jonesboro, Arkansas, Forenede Stater, 72401
    - GSK Investigational Site
- California
  - Anaheim, California, Forenede Stater, 92801
    - GSK Investigational Site
  - Bakersfield, California, Forenede Stater, 93301
    - GSK Investigational Site
  - Cerritos, California, Forenede Stater, 90703
    - GSK Investigational Site
  - Encinitas, California, Forenede Stater, 92024
    - GSK Investigational Site
  - Foothill Ranch, California, Forenede Stater, 92610
    - GSK Investigational Site
  - Fountain Valley, California, Forenede Stater, 92708
    - GSK Investigational Site
  - Garden Grove, California, Forenede Stater, 92844
    - GSK Investigational Site
  - Gold River, California, Forenede Stater, 95670
    - GSK Investigational Site
  - Huntington Beach, California, Forenede Stater, 92647
    - GSK Investigational Site
  - Huntington Park, California, Forenede Stater, 90255
    - GSK Investigational Site
  - Lakewood, California, Forenede Stater, 90712
    - GSK Investigational Site
  - Lancaster, California, Forenede Stater, 93534
    - GSK Investigational Site
  - Loma Linda, California, Forenede Stater, 92357
    - GSK Investigational Site
  - Long Beach, California, Forenede Stater, 90822
    - GSK Investigational Site
  - Los Angeles, California, Forenede Stater, 90095
    - GSK Investigational Site
  - Los Angeles, California, Forenede Stater, 90048
    - GSK Investigational Site
  - Los Angeles, California, Forenede Stater, 90033
    - GSK Investigational Site
  - Los Angeles, California, Forenede Stater, 90036
    - GSK Investigational Site
  - Mission Hills, California, Forenede Stater, 91345
    - GSK Investigational Site
  - Mission Viejo, California, Forenede Stater, 92691
    - GSK Investigational Site
  - Modesto, California, Forenede Stater, 95350
    - GSK Investigational Site
  - Montclair, California, Forenede Stater, 91763
    - GSK Investigational Site
  - Monterey Park, California, Forenede Stater, 91754
    - GSK Investigational Site
  - Oxnard, California, Forenede Stater, 93030-5841
    - GSK Investigational Site
  - Palo Alto, California, Forenede Stater, 94304
    - GSK Investigational Site
  - Pasadena, California, Forenede Stater, 91105
    - GSK Investigational Site
  - Pismo Beach, California, Forenede Stater, 93449
    - GSK Investigational Site
  - Rancho Mirage, California, Forenede Stater, 92270
    - GSK Investigational Site
  - Riverside, California, Forenede Stater, 92506
    - GSK Investigational Site
  - Rolling Hills Estates, California, Forenede Stater, 90274
    - GSK Investigational Site
  - Sacramento, California, Forenede Stater, 95821
    - GSK Investigational Site
  - Sacramento, California, Forenede Stater, 95816
    - GSK Investigational Site
  - Sacramento, California, Forenede Stater, 95817
    - GSK Investigational Site
  - Sacramento, California, Forenede Stater, 95819
    - GSK Investigational Site
  - San Diego, California, Forenede Stater, 92103
    - GSK Investigational Site
  - San Diego, California, Forenede Stater, 92120
    - GSK Investigational Site
  - San Diego, California, Forenede Stater, 92117
    - GSK Investigational Site
  - San Diego, California, Forenede Stater, 92108
    - GSK Investigational Site
  - San Diego, California, Forenede Stater, 92111
    - GSK Investigational Site
  - San Diego, California, Forenede Stater, 91910
    - GSK Investigational Site
  - San Gabriel, California, Forenede Stater, 91776
    - GSK Investigational Site
  - San Jose, California, Forenede Stater, 95116
    - GSK Investigational Site
  - San Marino, California, Forenede Stater, 91108
    - GSK Investigational Site
  - Santa Monica, California, Forenede Stater, 90404
    - GSK Investigational Site
  - Sepulveda, California, Forenede Stater, 91343
    - GSK Investigational Site
  - Simi Valley, California, Forenede Stater, 93065
    - GSK Investigational Site
  - Stockton, California, Forenede Stater, 95207
    - GSK Investigational Site
  - Torrance, California, Forenede Stater, 90502
    - GSK Investigational Site
  - Torrance, California, Forenede Stater, 90505
    - GSK Investigational Site
  - Van Nuys, California, Forenede Stater, 91405
    - GSK Investigational Site
  - Ventura, California, Forenede Stater, 93003
    - GSK Investigational Site
  - West Covina, California, Forenede Stater, 91790
    - GSK Investigational Site
- Colorado
  - Centennial, Colorado, Forenede Stater, 80112
    - GSK Investigational Site
  - Colorado Springs, Colorado, Forenede Stater, 80907
    - GSK Investigational Site
  - Colorado Springs, Colorado, Forenede Stater, 80910
    - GSK Investigational Site
  - Denver, Colorado, Forenede Stater, 80206
    - GSK Investigational Site
  - Fort Collins, Colorado, Forenede Stater, 80528
    - GSK Investigational Site
  - Fort Collins, Colorado, Forenede Stater, 80538
    - GSK Investigational Site
  - Wheat Ridge, Colorado, Forenede Stater, 80033
    - GSK Investigational Site
- Connecticut
  - Danbury, Connecticut, Forenede Stater, 06810
    - GSK Investigational Site
  - Hartford, Connecticut, Forenede Stater, 06105
    - GSK Investigational Site
  - Waterbury, Connecticut, Forenede Stater, 06708
    - GSK Investigational Site
- District of Columbia
  - Washington, District of Columbia, Forenede Stater, 20422
    - GSK Investigational Site
- Florida
  - Altamonte Springs, Florida, Forenede Stater, 32714
    - GSK Investigational Site
  - Aventura, Florida, Forenede Stater, 33180
    - GSK Investigational Site
  - Bay Pines, Florida, Forenede Stater, 33744
    - GSK Investigational Site
  - Boynton Beach, Florida, Forenede Stater, 33435
    - GSK Investigational Site
  - Boynton Beach, Florida, Forenede Stater, 33472
    - GSK Investigational Site
  - Brandon, Florida, Forenede Stater, 33511
    - GSK Investigational Site
  - Celebration, Florida, Forenede Stater, 34747
    - GSK Investigational Site
  - Clearwater, Florida, Forenede Stater, 33756
    - GSK Investigational Site
  - Clearwater, Florida, Forenede Stater, 33765-2616
    - GSK Investigational Site
  - Clearwater, Florida, Forenede Stater, 33765
    - GSK Investigational Site
  - Clearwater, Florida, Forenede Stater, 33755
    - GSK Investigational Site
  - Clearwater, Florida, Forenede Stater, 33759
    - GSK Investigational Site
  - Crystal River, Florida, Forenede Stater, 34429
    - GSK Investigational Site
  - Daytona Beach, Florida, Forenede Stater, 32117
    - GSK Investigational Site
  - DeBary, Florida, Forenede Stater, 32173
    - GSK Investigational Site
  - DeLand, Florida, Forenede Stater, 32720
    - GSK Investigational Site
  - Edgewater, Florida, Forenede Stater, 32132
    - GSK Investigational Site
  - Fleming Island, Florida, Forenede Stater, 32003
    - GSK Investigational Site
  - Fort Lauderdale, Florida, Forenede Stater, 33316
    - GSK Investigational Site
  - Gainesville, Florida, Forenede Stater, 32608
    - GSK Investigational Site
  - Hialeah, Florida, Forenede Stater, 33012
    - GSK Investigational Site
  - Hialeah, Florida, Forenede Stater, 33013
    - GSK Investigational Site
  - Hialeah, Florida, Forenede Stater, 33016
    - GSK Investigational Site
  - Hollywood, Florida, Forenede Stater, 33021
    - GSK Investigational Site
  - Jacksonville, Florida, Forenede Stater, 32216
    - GSK Investigational Site
  - Jacksonville, Florida, Forenede Stater, 32209
    - GSK Investigational Site
  - Kissimmee, Florida, Forenede Stater, 34741
    - GSK Investigational Site
  - Leesburg, Florida, Forenede Stater, 34748
    - GSK Investigational Site
  - Lehigh Acres, Florida, Forenede Stater, 33971
    - GSK Investigational Site
  - Maitland, Florida, Forenede Stater, 32751
    - GSK Investigational Site
  - Melbourne, Florida, Forenede Stater, 32934
    - GSK Investigational Site
  - Miami, Florida, Forenede Stater, 33125
    - GSK Investigational Site
  - Miami, Florida, Forenede Stater, 33126
    - GSK Investigational Site
  - Miami, Florida, Forenede Stater, 33135
    - GSK Investigational Site
  - Miami, Florida, Forenede Stater, 33142
    - GSK Investigational Site
  - Miami, Florida, Forenede Stater, 33175
    - GSK Investigational Site
  - Miami, Florida, Forenede Stater, 33144
    - GSK Investigational Site
  - Miami, Florida, Forenede Stater, 33165
    - GSK Investigational Site
  - Miami, Florida, Forenede Stater, 33174
    - GSK Investigational Site
  - Miami, Florida, Forenede Stater, 33186
    - GSK Investigational Site
  - Miami, Florida, Forenede Stater, 33155
    - GSK Investigational Site
  - Miami, Florida, Forenede Stater, 33185
    - GSK Investigational Site
  - Miami, Florida, Forenede Stater, 33015
    - GSK Investigational Site
  - Miami, Florida, Forenede Stater, 33133
    - GSK Investigational Site
  - Miami Gardens, Florida, Forenede Stater, 33169
    - GSK Investigational Site
  - New Port Richey, Florida, Forenede Stater, 34652
    - GSK Investigational Site
  - North Miami Beach, Florida, Forenede Stater, 33179
    - GSK Investigational Site
  - Oakland Park, Florida, Forenede Stater, 33309
    - GSK Investigational Site
  - Ocala, Florida, Forenede Stater, 34471
    - GSK Investigational Site
  - Orlando, Florida, Forenede Stater, 32803
    - GSK Investigational Site
  - Orlando, Florida, Forenede Stater, 32825
    - GSK Investigational Site
  - Orlando, Florida, Forenede Stater, 32811
    - GSK Investigational Site
  - Palm Harbor, Florida, Forenede Stater, 34684
    - GSK Investigational Site
  - Pembroke Pines, Florida, Forenede Stater, 33027
    - GSK Investigational Site
  - Pensacola, Florida, Forenede Stater, 32503
    - GSK Investigational Site
  - Pensacola, Florida, Forenede Stater, 32514
    - GSK Investigational Site
  - Pinellas Park, Florida, Forenede Stater, 33781
    - GSK Investigational Site
  - Port Charlotte, Florida, Forenede Stater, 33952
    - GSK Investigational Site
  - Port Orange, Florida, Forenede Stater, 32129
    - GSK Investigational Site
  - Saint Petersburg, Florida, Forenede Stater, 33713
    - GSK Investigational Site
  - Saint Petersburg, Florida, Forenede Stater, 33709
    - GSK Investigational Site
  - Saint Petersburg, Florida, Forenede Stater, 33707
    - GSK Investigational Site
  - Saint Petersburg, Florida, Forenede Stater, 33704
    - GSK Investigational Site
  - Sarasota, Florida, Forenede Stater, 34239
    - GSK Investigational Site
  - South Miami, Florida, Forenede Stater, 33143
    - GSK Investigational Site
  - Summerfield, Florida, Forenede Stater, 34491
    - GSK Investigational Site
  - Tamarac, Florida, Forenede Stater, 33319
    - GSK Investigational Site
  - Tampa, Florida, Forenede Stater, 33613
    - GSK Investigational Site
  - Tampa, Florida, Forenede Stater, 33603
    - GSK Investigational Site
  - Tampa, Florida, Forenede Stater, 33607
    - GSK Investigational Site
  - Trinity, Florida, Forenede Stater, 34655
    - GSK Investigational Site
  - Vero Beach, Florida, Forenede Stater, 32960
    - GSK Investigational Site
  - Vero Beach, Florida, Forenede Stater, 32958
    - GSK Investigational Site
  - Wellington, Florida, Forenede Stater, 33414
    - GSK Investigational Site
  - Winter Park, Florida, Forenede Stater, 32789
    - GSK Investigational Site
  - Zephyrhills, Florida, Forenede Stater, 33540
    - GSK Investigational Site
- Georgia
  - Atlanta, Georgia, Forenede Stater, 30342
    - GSK Investigational Site
  - Austell, Georgia, Forenede Stater, 30106
    - GSK Investigational Site
  - Blue Ridge, Georgia, Forenede Stater, 30513
    - GSK Investigational Site
  - Calhoun, Georgia, Forenede Stater, 30701
    - GSK Investigational Site
  - Canton, Georgia, Forenede Stater, 30114
    - GSK Investigational Site
  - Columbus, Georgia, Forenede Stater, 31904
    - GSK Investigational Site
  - Cumming, Georgia, Forenede Stater, 30041
    - GSK Investigational Site
  - Decatur, Georgia, Forenede Stater, 30033
    - GSK Investigational Site
  - Gainesville, Georgia, Forenede Stater, 30501
    - GSK Investigational Site
  - Lawrenceville, Georgia, Forenede Stater, 30046
    - GSK Investigational Site
  - Marietta, Georgia, Forenede Stater, 30060
    - GSK Investigational Site
  - Rincon, Georgia, Forenede Stater, 31326
    - GSK Investigational Site
  - Suwanee, Georgia, Forenede Stater, 30024
    - GSK Investigational Site
  - Woodstock, Georgia, Forenede Stater, 30189
    - GSK Investigational Site
- Hawaii
  - Honolulu, Hawaii, Forenede Stater, 96813
    - GSK Investigational Site
- Idaho
  - Boise, Idaho, Forenede Stater, 83642
    - GSK Investigational Site
  - Coeur d'Alene, Idaho, Forenede Stater, 90212
    - GSK Investigational Site
  - Hayden Lake, Idaho, Forenede Stater, 83835
    - GSK Investigational Site
  - Idaho Falls, Idaho, Forenede Stater, 83402
    - GSK Investigational Site
  - Nampa, Idaho, Forenede Stater, 83687
    - GSK Investigational Site
- Illinois
  - Aurora, Illinois, Forenede Stater, 60504
    - GSK Investigational Site
  - Champaign, Illinois, Forenede Stater, 61820
    - GSK Investigational Site
  - Chicago, Illinois, Forenede Stater, 60612
    - GSK Investigational Site
  - Chicago, Illinois, Forenede Stater, 60603
    - GSK Investigational Site
  - Evergreen Park, Illinois, Forenede Stater, 60805
    - GSK Investigational Site
  - Gillespie, Illinois, Forenede Stater, 62033
    - GSK Investigational Site
  - Melrose Park, Illinois, Forenede Stater, 60160
    - GSK Investigational Site
  - North Chicago, Illinois, Forenede Stater, 60064
    - GSK Investigational Site
  - Oak Lawn, Illinois, Forenede Stater, 60453
    - GSK Investigational Site
  - Peoria, Illinois, Forenede Stater, 61602
    - GSK Investigational Site
  - Quincy, Illinois, Forenede Stater, 62301
    - GSK Investigational Site
  - River Forest, Illinois, Forenede Stater, 60305
    - GSK Investigational Site
  - Skokie, Illinois, Forenede Stater, 60076
    - GSK Investigational Site
- Indiana
  - Avon, Indiana, Forenede Stater, 46123
    - GSK Investigational Site
  - Elwood, Indiana, Forenede Stater, 46036
    - GSK Investigational Site
  - Evansville, Indiana, Forenede Stater, 47714
    - GSK Investigational Site
  - Franklin, Indiana, Forenede Stater, 46131
    - GSK Investigational Site
  - Greenfield, Indiana, Forenede Stater, 46140
    - GSK Investigational Site
  - Muncie, Indiana, Forenede Stater, 47304-5547
    - GSK Investigational Site
  - Valparaiso, Indiana, Forenede Stater, 46383
    - GSK Investigational Site
- Iowa
  - Council Bluffs, Iowa, Forenede Stater, 51503
    - GSK Investigational Site
  - Dubuque, Iowa, Forenede Stater, 52001
    - GSK Investigational Site
  - Iowa City, Iowa, Forenede Stater, 52242
    - GSK Investigational Site
  - West Des Moines, Iowa, Forenede Stater, 50265
    - GSK Investigational Site
- Kansas
  - Newton, Kansas, Forenede Stater, 67114
    - GSK Investigational Site
  - Olathe, Kansas, Forenede Stater, 66061
    - GSK Investigational Site
  - Topeka, Kansas, Forenede Stater, 66606
    - GSK Investigational Site
  - Topeka, Kansas, Forenede Stater, 66615
    - GSK Investigational Site
  - Wichita, Kansas, Forenede Stater, 67218
    - GSK Investigational Site
- Kentucky
  - Bowling Green, Kentucky, Forenede Stater, 42101
    - GSK Investigational Site
  - Crestview Hills, Kentucky, Forenede Stater, 41017
    - GSK Investigational Site
  - Hawesville, Kentucky, Forenede Stater, 42348
    - GSK Investigational Site
  - Hazard, Kentucky, Forenede Stater, 41701
    - GSK Investigational Site
  - Lexington, Kentucky, Forenede Stater, 40504
    - GSK Investigational Site
  - Louisville, Kentucky, Forenede Stater, 40202
    - GSK Investigational Site
  - Owensboro, Kentucky, Forenede Stater, 42303-3163
    - GSK Investigational Site
- Louisiana
  - Lafayette, Louisiana, Forenede Stater, 70508
    - GSK Investigational Site
  - Metairie, Louisiana, Forenede Stater, 70006
    - GSK Investigational Site
  - Opelousas, Louisiana, Forenede Stater, 70570
    - GSK Investigational Site
- Maine
  - Auburn, Maine, Forenede Stater, 04210
    - GSK Investigational Site
  - Bangor, Maine, Forenede Stater, 04401
    - GSK Investigational Site
  - Biddeford, Maine, Forenede Stater, 04005
    - GSK Investigational Site
- Maryland
  - Baltimore, Maryland, Forenede Stater, 21224
    - GSK Investigational Site
  - Baltimore, Maryland, Forenede Stater, 21201
    - GSK Investigational Site
  - Baltimore, Maryland, Forenede Stater, 21239
    - GSK Investigational Site
  - Columbia, Maryland, Forenede Stater, 21044
    - GSK Investigational Site
  - Elkton, Maryland, Forenede Stater, 21921
    - GSK Investigational Site
  - Hagerstown, Maryland, Forenede Stater, 21740
    - GSK Investigational Site
  - Hollywood, Maryland, Forenede Stater, 20636
    - GSK Investigational Site
  - Lutherville, Maryland, Forenede Stater, 21093
    - GSK Investigational Site
  - Oxon Hill, Maryland, Forenede Stater, 20745
    - GSK Investigational Site
  - Towson, Maryland, Forenede Stater, 21204
    - GSK Investigational Site
- Massachusetts
  - Brockton, Massachusetts, Forenede Stater, 02301
    - GSK Investigational Site
  - Fall River, Massachusetts, Forenede Stater, 02720
    - GSK Investigational Site
  - North Dartmouth, Massachusetts, Forenede Stater, 02747
    - GSK Investigational Site
- Michigan
  - Ann Arbor, Michigan, Forenede Stater, 48106
    - GSK Investigational Site
  - Buckley, Michigan, Forenede Stater, 49620
    - GSK Investigational Site
  - Cadillac, Michigan, Forenede Stater, 49601
    - GSK Investigational Site
  - Detroit, Michigan, Forenede Stater, 48235
    - GSK Investigational Site
  - Detroit, Michigan, Forenede Stater, 48201
    - GSK Investigational Site
  - Detroit, Michigan, Forenede Stater, 48221
    - GSK Investigational Site
  - Grand Blanc, Michigan, Forenede Stater, 48439
    - GSK Investigational Site
  - Kalamazoo, Michigan, Forenede Stater, 49009
    - GSK Investigational Site
  - Niles, Michigan, Forenede Stater, 49120
    - GSK Investigational Site
  - Rochester, Michigan, Forenede Stater, 48307
    - GSK Investigational Site
  - Royal Oak, Michigan, Forenede Stater, 48073-6769
    - GSK Investigational Site
  - Traverse City, Michigan, Forenede Stater, 49684
    - GSK Investigational Site
  - Troy, Michigan, Forenede Stater, 48098
    - GSK Investigational Site
  - Troy, Michigan, Forenede Stater, 48085
    - GSK Investigational Site
- Minnesota
  - Coon Rapids, Minnesota, Forenede Stater, 55433
    - GSK Investigational Site
  - Edina, Minnesota, Forenede Stater, 55435
    - GSK Investigational Site
  - Fridley, Minnesota, Forenede Stater, 55432
    - GSK Investigational Site
  - Minneapolis, Minnesota, Forenede Stater, 55407
    - GSK Investigational Site
  - Minneapolis, Minnesota, Forenede Stater, 55402
    - GSK Investigational Site
  - Minneapolis, Minnesota, Forenede Stater, 55417
    - GSK Investigational Site
  - Plymouth, Minnesota, Forenede Stater, 55441
    - GSK Investigational Site
  - Rochester, Minnesota, Forenede Stater, 55905
    - GSK Investigational Site
  - Saint Paul, Minnesota, Forenede Stater, 55130
    - GSK Investigational Site
  - Woodbury, Minnesota, Forenede Stater, 55125
    - GSK Investigational Site
- Missouri
  - Chesterfield, Missouri, Forenede Stater, 63017
    - GSK Investigational Site
  - Kansas City, Missouri, Forenede Stater, 64128
    - GSK Investigational Site
  - Kansas City, Missouri, Forenede Stater, 64106
    - GSK Investigational Site
  - Saint Louis, Missouri, Forenede Stater, 63141
    - GSK Investigational Site
  - Saint Louis, Missouri, Forenede Stater, 63143
    - GSK Investigational Site
  - Saint Louis, Missouri, Forenede Stater, 63117
    - GSK Investigational Site
- Montana
  - Billings, Montana, Forenede Stater, 59102
    - GSK Investigational Site
  - Billings, Montana, Forenede Stater, 59101
    - GSK Investigational Site
  - Butte, Montana, Forenede Stater, 59701
    - GSK Investigational Site
  - Great Falls, Montana, Forenede Stater, 59405
    - GSK Investigational Site
  - Missoula, Montana, Forenede Stater, 59808
    - GSK Investigational Site
- Nebraska
  - Bellevue, Nebraska, Forenede Stater, 68123-4303
    - GSK Investigational Site
  - Fremont, Nebraska, Forenede Stater, 68025
    - GSK Investigational Site
  - Grand Island, Nebraska, Forenede Stater, 68803
    - GSK Investigational Site
  - Lincoln, Nebraska, Forenede Stater, 68516
    - GSK Investigational Site
  - Lincoln, Nebraska, Forenede Stater, 68506
    - GSK Investigational Site
  - Lincoln, Nebraska, Forenede Stater, 02865
    - GSK Investigational Site
  - Lincoln, Nebraska, Forenede Stater, 68512
    - GSK Investigational Site
  - Omaha, Nebraska, Forenede Stater, 68198
    - GSK Investigational Site
  - Omaha, Nebraska, Forenede Stater, 68114
    - GSK Investigational Site
  - Omaha, Nebraska, Forenede Stater, 68134
    - GSK Investigational Site
- Nevada
  - Henderson, Nevada, Forenede Stater, 89014
    - GSK Investigational Site
  - Las Vegas, Nevada, Forenede Stater, 89119
    - GSK Investigational Site
  - Las Vegas, Nevada, Forenede Stater, 89106
    - GSK Investigational Site
  - Reno, Nevada, Forenede Stater, 89502
    - GSK Investigational Site
- New Jersey
  - Brick, New Jersey, Forenede Stater, 08723
    - GSK Investigational Site
  - Edison, New Jersey, Forenede Stater, 8820
    - GSK Investigational Site
  - Elizabeth, New Jersey, Forenede Stater, 07202
    - GSK Investigational Site
  - Elizabeth, New Jersey, Forenede Stater, 07201
    - GSK Investigational Site
  - Freehold, New Jersey, Forenede Stater, 07728
    - GSK Investigational Site
  - Linden, New Jersey, Forenede Stater, 07036
    - GSK Investigational Site
  - Lodi, New Jersey, Forenede Stater, 07644
    - GSK Investigational Site
  - Margate City, New Jersey, Forenede Stater, 08402
    - GSK Investigational Site
  - Princeton, New Jersey, Forenede Stater, 08540
    - GSK Investigational Site
  - Salem, New Jersey, Forenede Stater, 08079
    - GSK Investigational Site
  - Verona, New Jersey, Forenede Stater, 07044
    - GSK Investigational Site
- New Mexico
  - Albuquerque, New Mexico, Forenede Stater, 87108
    - GSK Investigational Site
- New York
  - Albany, New York, Forenede Stater, 12208
    - GSK Investigational Site
  - Bronx, New York, Forenede Stater, 10461
    - GSK Investigational Site
  - Bronx, New York, Forenede Stater, 10457
    - GSK Investigational Site
  - Bronxville, New York, Forenede Stater, 10708
    - GSK Investigational Site
  - Brooklyn, New York, Forenede Stater, 11229
    - GSK Investigational Site
  - Brooklyn, New York, Forenede Stater, 11215
    - GSK Investigational Site
  - Buffalo, New York, Forenede Stater, 14215-1199
    - GSK Investigational Site
  - Corning, New York, Forenede Stater, 14830
    - GSK Investigational Site
  - Great Neck, New York, Forenede Stater, 11023
    - GSK Investigational Site
  - Manhattan, New York, Forenede Stater, 10029
    - GSK Investigational Site
  - Massapequa, New York, Forenede Stater, 11758
    - GSK Investigational Site
  - New York, New York, Forenede Stater, 10021
    - GSK Investigational Site
  - New York, New York, Forenede Stater, 10016
    - GSK Investigational Site
  - New York, New York, Forenede Stater, 10001
    - GSK Investigational Site
  - New York, New York, Forenede Stater, 10038
    - GSK Investigational Site
  - New York, New York, Forenede Stater, 10004
    - GSK Investigational Site
  - New York, New York, Forenede Stater, 10009
    - GSK Investigational Site
  - New York, New York, Forenede Stater, 10028
    - GSK Investigational Site
  - New York, New York, Forenede Stater, 10019
    - GSK Investigational Site
  - Rochester, New York, Forenede Stater, 14618
    - GSK Investigational Site
  - Syracuse, New York, Forenede Stater, 13210
    - GSK Investigational Site
  - Westfield, New York, Forenede Stater, 14787
    - GSK Investigational Site
- North Carolina
  - Asheville, North Carolina, Forenede Stater, 28801
    - GSK Investigational Site
  - Calabash, North Carolina, Forenede Stater, 28467
    - GSK Investigational Site
  - Charlotte, North Carolina, Forenede Stater, 28209
    - GSK Investigational Site
  - Charlotte, North Carolina, Forenede Stater, 28210
    - GSK Investigational Site
  - Elizabeth City, North Carolina, Forenede Stater, 27909
    - GSK Investigational Site
  - Greensboro, North Carolina, Forenede Stater, 27405
    - GSK Investigational Site
  - Greensboro, North Carolina, Forenede Stater, 27403
    - GSK Investigational Site
  - Greensboro, North Carolina, Forenede Stater, 27401
    - GSK Investigational Site
  - Greensboro, North Carolina, Forenede Stater, 27408
    - GSK Investigational Site
  - Greenville, North Carolina, Forenede Stater, 27858
    - GSK Investigational Site
  - High Point, North Carolina, Forenede Stater, 27262
    - GSK Investigational Site
  - Huntersville, North Carolina, Forenede Stater, 28078
    - GSK Investigational Site
  - Knightdale, North Carolina, Forenede Stater, 27545
    - GSK Investigational Site
  - Lexington, North Carolina, Forenede Stater, 27295
    - GSK Investigational Site
  - Morganton, North Carolina, Forenede Stater, 28655
    - GSK Investigational Site
  - Salisbury, North Carolina, Forenede Stater, 28144
    - GSK Investigational Site
  - Shelby, North Carolina, Forenede Stater, 28152
    - GSK Investigational Site
  - Smithfield, North Carolina, Forenede Stater, 27577
    - GSK Investigational Site
  - Statesville, North Carolina, Forenede Stater, 28625
    - GSK Investigational Site
  - Wilmington, North Carolina, Forenede Stater, 28401
    - GSK Investigational Site
  - Winston-Salem, North Carolina, Forenede Stater, 27103
    - GSK Investigational Site
- Ohio
  - Akron, Ohio, Forenede Stater, 44313
    - GSK Investigational Site
  - Chardon, Ohio, Forenede Stater, 44024
    - GSK Investigational Site
  - Cincinnati, Ohio, Forenede Stater, 45231
    - GSK Investigational Site
  - Cincinnati, Ohio, Forenede Stater, 45242
    - GSK Investigational Site
  - Cincinnati, Ohio, Forenede Stater, 45220
    - GSK Investigational Site
  - Cleveland, Ohio, Forenede Stater, 44106
    - GSK Investigational Site
  - Cleveland, Ohio, Forenede Stater, 44122
    - GSK Investigational Site
  - Cleveland, Ohio, Forenede Stater, 44109
    - GSK Investigational Site
  - Columbus, Ohio, Forenede Stater, 43215
    - GSK Investigational Site
  - Columbus, Ohio, Forenede Stater, 43213
    - GSK Investigational Site
  - Columbus, Ohio, Forenede Stater, 43214
    - GSK Investigational Site
  - Columbus, Ohio, Forenede Stater, 43235
    - GSK Investigational Site
  - Dayton, Ohio, Forenede Stater, 45406
    - GSK Investigational Site
  - Dayton, Ohio, Forenede Stater, 45459
    - GSK Investigational Site
  - Kettering, Ohio, Forenede Stater, 45429
    - GSK Investigational Site
  - Marion, Ohio, Forenede Stater, 43302
    - GSK Investigational Site
  - Maumee, Ohio, Forenede Stater, 43537-9402
    - GSK Investigational Site
  - Miamisburg, Ohio, Forenede Stater, 45342
    - GSK Investigational Site
  - Toledo, Ohio, Forenede Stater, 43606
    - GSK Investigational Site
  - Toledo, Ohio, Forenede Stater, 43614-5809
    - GSK Investigational Site
  - Toledo, Ohio, Forenede Stater, 43617
    - GSK Investigational Site
  - Wooster, Ohio, Forenede Stater, 44691
    - GSK Investigational Site
  - Youngstown, Ohio, Forenede Stater, 44501
    - GSK Investigational Site
- Oklahoma
  - Oklahoma City, Oklahoma, Forenede Stater, 73103
    - GSK Investigational Site
  - Tulsa, Oklahoma, Forenede Stater, 74136
    - GSK Investigational Site
  - Tulsa, Oklahoma, Forenede Stater, 74127
    - GSK Investigational Site
- Oregon
  - Bend, Oregon, Forenede Stater, 97701
    - GSK Investigational Site
  - Portland, Oregon, Forenede Stater, 97202
    - GSK Investigational Site
  - Portland, Oregon, Forenede Stater, 97219
    - GSK Investigational Site
  - Springfield, Oregon, Forenede Stater, 97477
    - GSK Investigational Site
- Pennsylvania
  - Beaver, Pennsylvania, Forenede Stater, 15009
    - GSK Investigational Site
  - Belle Vernon, Pennsylvania, Forenede Stater, 15012
    - GSK Investigational Site
  - Bensalem, Pennsylvania, Forenede Stater, 19020
    - GSK Investigational Site
  - Clairton, Pennsylvania, Forenede Stater, 15025
    - GSK Investigational Site
  - Downingtown, Pennsylvania, Forenede Stater, 19335
    - GSK Investigational Site
  - Doylestown, Pennsylvania, Forenede Stater, 18901
    - GSK Investigational Site
  - Erie, Pennsylvania, Forenede Stater, 16508
    - GSK Investigational Site
  - Fleetwood, Pennsylvania, Forenede Stater, 19522
    - GSK Investigational Site
  - Harleysville, Pennsylvania, Forenede Stater, 19438
    - GSK Investigational Site
  - Jersey Shore, Pennsylvania, Forenede Stater, 17740
    - GSK Investigational Site
  - Langhorne, Pennsylvania, Forenede Stater, 19047
    - GSK Investigational Site
  - Lansdale, Pennsylvania, Forenede Stater, 19446
    - GSK Investigational Site
  - Monroeville, Pennsylvania, Forenede Stater, 15146
    - GSK Investigational Site
  - Philadelphia, Pennsylvania, Forenede Stater, 19107
    - GSK Investigational Site
  - Philadelphia, Pennsylvania, Forenede Stater, 19140
    - GSK Investigational Site
  - Philadelphia, Pennsylvania, Forenede Stater, 19152
    - GSK Investigational Site
  - Philadelphia, Pennsylvania, Forenede Stater, 19142
    - GSK Investigational Site
  - Phoenixville, Pennsylvania, Forenede Stater, 19460
    - GSK Investigational Site
  - Pittsburgh, Pennsylvania, Forenede Stater, 15236
    - GSK Investigational Site
  - Pittsburgh, Pennsylvania, Forenede Stater, 15213
    - GSK Investigational Site
  - Pittsburgh, Pennsylvania, Forenede Stater, 15243
    - GSK Investigational Site
  - Scottdale, Pennsylvania, Forenede Stater, 15683
    - GSK Investigational Site
  - Scranton, Pennsylvania, Forenede Stater, 18501
    - GSK Investigational Site
  - Uniontown, Pennsylvania, Forenede Stater, 15401
    - GSK Investigational Site
  - Warminster, Pennsylvania, Forenede Stater, 18974
    - GSK Investigational Site
- Rhode Island
  - Cumberland, Rhode Island, Forenede Stater, 02864
    - GSK Investigational Site
  - East Providence, Rhode Island, Forenede Stater, 02914
    - GSK Investigational Site
  - Johnston, Rhode Island, Forenede Stater, 02919
    - GSK Investigational Site
- South Carolina
  - Anderson, South Carolina, Forenede Stater, 29621
    - GSK Investigational Site
  - Charleston, South Carolina, Forenede Stater, 29407
    - GSK Investigational Site
  - Charleston, South Carolina, Forenede Stater, 29406-7108
    - GSK Investigational Site
  - Columbia, South Carolina, Forenede Stater, 29201
    - GSK Investigational Site
  - Columbia, South Carolina, Forenede Stater, 29209
    - GSK Investigational Site
  - Easley, South Carolina, Forenede Stater, 29640
    - GSK Investigational Site
  - Florence, South Carolina, Forenede Stater, 29501
    - GSK Investigational Site
  - Gaffney, South Carolina, Forenede Stater, 29340
    - GSK Investigational Site
  - Greenville, South Carolina, Forenede Stater, 29615
    - GSK Investigational Site
  - Greenwood, South Carolina, Forenede Stater, 29646
    - GSK Investigational Site
  - Greer, South Carolina, Forenede Stater, 29651
    - GSK Investigational Site
  - Greer, South Carolina, Forenede Stater, 29650
    - GSK Investigational Site
  - Indian Land, South Carolina, Forenede Stater, 29707
    - GSK Investigational Site
  - Murrells Inlet, South Carolina, Forenede Stater, 29576
    - GSK Investigational Site
  - Pelzer, South Carolina, Forenede Stater, 29669
    - GSK Investigational Site
  - Rock Hill, South Carolina, Forenede Stater, 29732
    - GSK Investigational Site
  - Spartanburg, South Carolina, Forenede Stater, 29303
    - GSK Investigational Site
  - Williamston, South Carolina, Forenede Stater, 29697
    - GSK Investigational Site
- South Dakota
  - Dakota Dunes, South Dakota, Forenede Stater, 57049
    - GSK Investigational Site
  - Rapid City, South Dakota, Forenede Stater, 57702
    - GSK Investigational Site
- Tennessee
  - Chattanooga, Tennessee, Forenede Stater, 37404
    - GSK Investigational Site
  - Fayetteville, Tennessee, Forenede Stater, 37334
    - GSK Investigational Site
  - Franklin, Tennessee, Forenede Stater, 27064
    - GSK Investigational Site
  - Nashville, Tennessee, Forenede Stater, 37215
    - GSK Investigational Site
  - Shelbyville, Tennessee, Forenede Stater, 37160
    - GSK Investigational Site
- Texas
  - Amarillo, Texas, Forenede Stater, 79124
    - GSK Investigational Site
  - Austin, Texas, Forenede Stater, 78758
    - GSK Investigational Site
  - Austin, Texas, Forenede Stater, 78756
    - GSK Investigational Site
  - Boerne, Texas, Forenede Stater, 78006
    - GSK Investigational Site
  - Corpus Christi, Texas, Forenede Stater, 78405
    - GSK Investigational Site
  - Corsicana, Texas, Forenede Stater, 75110
    - GSK Investigational Site
  - Dallas, Texas, Forenede Stater, 75246
    - GSK Investigational Site
  - Dallas, Texas, Forenede Stater, 75216
    - GSK Investigational Site
  - Dallas, Texas, Forenede Stater, 75225
    - GSK Investigational Site
  - Dallas, Texas, Forenede Stater, 75254
    - GSK Investigational Site
  - Duncanville, Texas, Forenede Stater, 75116
    - GSK Investigational Site
  - Edinburg, Texas, Forenede Stater, 78539
    - GSK Investigational Site
  - Fort Worth, Texas, Forenede Stater, 76104
    - GSK Investigational Site
  - Frisco, Texas, Forenede Stater, 75034
    - GSK Investigational Site
  - Frisco, Texas, Forenede Stater, 75035
    - GSK Investigational Site
  - Galveston, Texas, Forenede Stater, 77555
    - GSK Investigational Site
  - Georgetown, Texas, Forenede Stater, 78626
    - GSK Investigational Site
  - Houston, Texas, Forenede Stater, 77030
    - GSK Investigational Site
  - Houston, Texas, Forenede Stater, 77074
    - GSK Investigational Site
  - Houston, Texas, Forenede Stater, 77081
    - GSK Investigational Site
  - Houston, Texas, Forenede Stater, 77099
    - GSK Investigational Site
  - Houston, Texas, Forenede Stater, 77024
    - GSK Investigational Site
  - Houston, Texas, Forenede Stater, 77034
    - GSK Investigational Site
  - Houston, Texas, Forenede Stater, 77025
    - GSK Investigational Site
  - Houston, Texas, Forenede Stater, 77043
    - GSK Investigational Site
  - Houston, Texas, Forenede Stater, 77029
    - GSK Investigational Site
  - Houston, Texas, Forenede Stater, 77062
    - GSK Investigational Site
  - Houston, Texas, Forenede Stater, 77077
    - GSK Investigational Site
  - Houston, Texas, Forenede Stater, 77079
    - GSK Investigational Site
  - Huntsville, Texas, Forenede Stater, 77340
    - GSK Investigational Site
  - Irving, Texas, Forenede Stater, 75039
    - GSK Investigational Site
  - Killeen, Texas, Forenede Stater, 76543
    - GSK Investigational Site
  - Kingwood, Texas, Forenede Stater, 77339
    - GSK Investigational Site
  - Lewisville, Texas, Forenede Stater, 75067
    - GSK Investigational Site
  - Longview, Texas, Forenede Stater, 75605
    - GSK Investigational Site
  - Lufkin, Texas, Forenede Stater, 75904
    - GSK Investigational Site
  - McKinney, Texas, Forenede Stater, 75069
    - GSK Investigational Site
  - McKinney, Texas, Forenede Stater, 75071
    - GSK Investigational Site
  - Plano, Texas, Forenede Stater, 75075
    - GSK Investigational Site
  - San Angelo, Texas, Forenede Stater, 76904
    - GSK Investigational Site
  - San Antonio, Texas, Forenede Stater, 78229
    - GSK Investigational Site
  - San Antonio, Texas, Forenede Stater, 78215
    - GSK Investigational Site
  - San Antonio, Texas, Forenede Stater, 78258
    - GSK Investigational Site
  - San Antonio, Texas, Forenede Stater, 78233
    - GSK Investigational Site
  - San Antonio, Texas, Forenede Stater, 78212
    - GSK Investigational Site
  - Sugar Land, Texas, Forenede Stater, 77478
    - GSK Investigational Site
  - Temple, Texas, Forenede Stater, 76508
    - GSK Investigational Site
  - Tyler, Texas, Forenede Stater, 75708
    - GSK Investigational Site
  - Tyler, Texas, Forenede Stater, 75701
    - GSK Investigational Site
  - Victoria, Texas, Forenede Stater, 77901
    - GSK Investigational Site
  - Waco, Texas, Forenede Stater, 76710
    - GSK Investigational Site
- Utah
  - Midvale, Utah, Forenede Stater, 84047
    - GSK Investigational Site
  - Orem, Utah, Forenede Stater, 84058
    - GSK Investigational Site
  - Salt Lake City, Utah, Forenede Stater, 84102
    - GSK Investigational Site
  - West Jordan, Utah, Forenede Stater, 84088
    - GSK Investigational Site
- Virginia
  - Abingdon, Virginia, Forenede Stater, 24210
    - GSK Investigational Site
  - Alexandria, Virginia, Forenede Stater, 22304
    - GSK Investigational Site
  - Burke, Virginia, Forenede Stater, 22015
    - GSK Investigational Site
  - Midlothian, Virginia, Forenede Stater, 23114
    - GSK Investigational Site
  - Norfolk, Virginia, Forenede Stater, 23507
    - GSK Investigational Site
  - Richmond, Virginia, Forenede Stater, 23249
    - GSK Investigational Site
  - Richmond, Virginia, Forenede Stater, 23229
    - GSK Investigational Site
  - Richmond, Virginia, Forenede Stater, 23235
    - GSK Investigational Site
  - Richmond, Virginia, Forenede Stater, 23220
    - GSK Investigational Site
  - Richmond, Virginia, Forenede Stater, 23219
    - GSK Investigational Site
  - Virginia Beach, Virginia, Forenede Stater, 23454
    - GSK Investigational Site
  - Winchester, Virginia, Forenede Stater, 22601
    - GSK Investigational Site
- Washington
  - Bellingham, Washington, Forenede Stater, 98225
    - GSK Investigational Site
  - Burien, Washington, Forenede Stater, 98166
    - GSK Investigational Site
  - Seattle, Washington, Forenede Stater, 98104
    - GSK Investigational Site
  - Spokane, Washington, Forenede Stater, 99204
    - GSK Investigational Site
  - Spokane, Washington, Forenede Stater, 99208
    - GSK Investigational Site
  - Spokane, Washington, Forenede Stater, 99202
    - GSK Investigational Site
  - Spokane, Washington, Forenede Stater, 99207
    - GSK Investigational Site
  - Tacoma, Washington, Forenede Stater, 98405
    - GSK Investigational Site
- West Virginia
  - Bridgeport, West Virginia, Forenede Stater, 26330
    - GSK Investigational Site
  - Morgantown, West Virginia, Forenede Stater, 26505
    - GSK Investigational Site
  - Morgantown, West Virginia, Forenede Stater, 28506
    - GSK Investigational Site
- Wisconsin
  - West Allis, Wisconsin, Forenede Stater, 53227
    - GSK Investigational Site
Frankrig
- - Ferolles Attilly, Frankrig, 77150
    - GSK Investigational Site
  - Paris Cedex 04, Frankrig, 75181
    - GSK Investigational Site
  - Strasbourg Cedex, Frankrig, 67091
    - GSK Investigational Site
  - Tarbes, Frankrig, 65013
    - GSK Investigational Site
  - Toulouse cedex 9, Frankrig, 31059
    - GSK Investigational Site
Georgien
- - Batumi, Georgien, 6000
    - GSK Investigational Site
  - Gurjaani, Georgien, 1500
    - GSK Investigational Site
  - Kutaisi, Georgien, 1600
    - GSK Investigational Site
  - Kvemo Kartli, Georgien, 3000
    - GSK Investigational Site
  - Tbilisi, Georgien, 0101
    - GSK Investigational Site
  - Tbilisi, Georgien, 0102
    - GSK Investigational Site
  - Tbilisi, Georgien, 0114
    - GSK Investigational Site
  - Tbilisi, Georgien, 0141
    - GSK Investigational Site
  - Tbilisi, Georgien, 0144
    - GSK Investigational Site
  - Tbilisi, Georgien, 0159
    - GSK Investigational Site
  - Tbilisi, Georgien, 0160
    - GSK Investigational Site
  - Tbilisi, Georgien, 0177
    - GSK Investigational Site
  - Tbilisi, Georgien, 0186
    - GSK Investigational Site
  - Tbilisi, Georgien, 0191
    - GSK Investigational Site
  - Tbilisi, Georgien
    - GSK Investigational Site
Grækenland
- - Athens, Grækenland, 11527
    - GSK Investigational Site
  - Athens, Grækenland, 15126
    - GSK Investigational Site
  - Thessaloniki, Grækenland, 57010
    - GSK Investigational Site
Holland
- - Alkmaar, Holland, 1815 JD
    - GSK Investigational Site
  - Almelo, Holland, 7609 PP
    - GSK Investigational Site
  - Ede Gld, Holland, 6717RP
    - GSK Investigational Site
  - Helmond, Holland, 5707 HA
    - GSK Investigational Site
  - Zutphen, Holland, 7207 AE
    - GSK Investigational Site
Hviderusland
- - Brest, Hviderusland, 224027
    - GSK Investigational Site
  - Gomel, Hviderusland, 246040
    - GSK Investigational Site
  - Grodno, Hviderusland, 230017
    - GSK Investigational Site
  - Minsk, Hviderusland, 220030
    - GSK Investigational Site
  - Minsk, Hviderusland, 220053
    - GSK Investigational Site
  - Minsk, Hviderusland, 223041
    - GSK Investigational Site
  - Vitebsk, Hviderusland, 210037
    - GSK Investigational Site
Indien
- - Ahmedabad, Indien, 380052
    - GSK Investigational Site
  - Ahmedabad, Indien, 380007
    - GSK Investigational Site
  - Alappuzha, Indien, 688524
    - GSK Investigational Site
  - Angamaly, Indien, 683 572
    - GSK Investigational Site
  - Aurangabad, Indien, 431001
    - GSK Investigational Site
  - Bangalore, Indien, 560 010
    - GSK Investigational Site
  - Bangalore, Indien, 560 054
    - GSK Investigational Site
  - Bangalore, Indien, 560034
    - GSK Investigational Site
  - Bangalore, Indien, 560076
    - GSK Investigational Site
  - Chennai, Indien, 600034
    - GSK Investigational Site
  - Chennai, Indien, 600100
    - GSK Investigational Site
  - Guntur, Indien, 522001
    - GSK Investigational Site
  - Hyderabad, Indien, 500004
    - GSK Investigational Site
  - Hyderabad, Indien, 500035
    - GSK Investigational Site
  - Hyderabad, Indien, 500038
    - GSK Investigational Site
  - Jaipur, Indien, 302006
    - GSK Investigational Site
  - Jaipur, Indien, 302022
    - GSK Investigational Site
  - Lucknow, Indien, 226018
    - GSK Investigational Site
  - Mysore, Indien, 570004
    - GSK Investigational Site
  - Mysore, Indien, 570002
    - GSK Investigational Site
  - Nagpur, Indien, 440012
    - GSK Investigational Site
  - Nagpur, Indien, 440019
    - GSK Investigational Site
  - Nashik, Indien, 422007
    - GSK Investigational Site
  - Nasik, Indien, 422005
    - GSK Investigational Site
  - Pune, Indien, 411014
    - GSK Investigational Site
  - Pune, Indien, 411015
    - GSK Investigational Site
  - Trisshur, Indien, 680 002
    - GSK Investigational Site
  - Trivandrum, Indien, 695004
    - GSK Investigational Site
  - Varanasi, Indien, 221005
    - GSK Investigational Site
  - Varanasi, Indien, 221001
    - GSK Investigational Site
  - Vijayawada, Indien, 520002
    - GSK Investigational Site
Indonesien
- - Banda Aceh, Indonesien, 23126
    - GSK Investigational Site
  - Banjarmasin, Indonesien, 70233
    - GSK Investigational Site
  - Bukittinggi, Indonesien, 26117
    - GSK Investigational Site
  - Denpasar, Indonesien, 80114
    - GSK Investigational Site
  - Depok Timur, Indonesien, 16411
    - GSK Investigational Site
  - Jakarta, Indonesien, 12430
    - GSK Investigational Site
  - Jakarta, Indonesien, 13230
    - GSK Investigational Site
  - Jakarta, Indonesien, 13630
    - GSK Investigational Site
  - Lampung Selatan, Indonesien, 35373
    - GSK Investigational Site
  - Makassar, Indonesien, 90245
    - GSK Investigational Site
  - Malang, Indonesien, 65100
    - GSK Investigational Site
  - Medan, Indonesien, 20111
    - GSK Investigational Site
  - Medan, Indonesien, 20154
    - GSK Investigational Site
  - Padang, Indonesien, 25127
    - GSK Investigational Site
  - Palembang, Indonesien, 30126
    - GSK Investigational Site
  - Pekanbaru, Indonesien, 28133
    - GSK Investigational Site
  - Pontianak, Indonesien, 78122
    - GSK Investigational Site
  - Pringsewu, Indonesien, 35373
    - GSK Investigational Site
  - Semarang, Indonesien, 50242
    - GSK Investigational Site
  - Surabaya, Indonesien, 60286
    - GSK Investigational Site
  - Surakarta, Indonesien, 57126
    - GSK Investigational Site
  - Yogyakarta, Indonesien, 55283
    - GSK Investigational Site
Israel
- - Afula, Israel, 18101
    - GSK Investigational Site
  - Ashkelon, Israel, 78306
    - GSK Investigational Site
  - Beer-Sheba, Israel, 84101
    - GSK Investigational Site
  - Hadera, Israel, PO Box 169
    - GSK Investigational Site
  - Haifa, Israel, 31096
    - GSK Investigational Site
  - Haifa, Israel, 34362
    - GSK Investigational Site
  - Holon, Israel, 68125
    - GSK Investigational Site
  - Jerusalem, Israel, 91120
    - GSK Investigational Site
  - Kfar Saba, Israel, 44281
    - GSK Investigational Site
  - Rehovot, Israel, 76100
    - GSK Investigational Site
  - Tel Aviv, Israel, 64239
    - GSK Investigational Site
  - Tel Hashomer, Israel, 52621
    - GSK Investigational Site
Italien
- Friuli-Venezia-Giulia
  - Pordenone, Friuli-Venezia-Giulia, Italien, 33170
    - GSK Investigational Site
Japan
- - Aichi, Japan, 457-8511
    - GSK Investigational Site
  - Aichi, Japan, 457-8510
    - GSK Investigational Site
  - Aichi, Japan, 454-8502
    - GSK Investigational Site
  - Fukuoka, Japan, 832-0059
    - GSK Investigational Site
  - Gifu, Japan, 500-8717
    - GSK Investigational Site
  - Hokkaido, Japan, 060-0033
    - GSK Investigational Site
  - Hokkaido, Japan, 070-8644
    - GSK Investigational Site
  - Hokkaido, Japan, 053-8506
    - GSK Investigational Site
  - Hyogo, Japan, 650-0047
    - GSK Investigational Site
  - Ibaraki, Japan, 319-1113
    - GSK Investigational Site
  - Kagawa, Japan, 762-0031
    - GSK Investigational Site
  - Kodaira, Japan, 187-0002
    - GSK Investigational Site
  - Kumamoto, Japan, 861-1196
    - GSK Investigational Site
  - Kyoto, Japan, 607-8062
    - GSK Investigational Site
  - Oita, Japan, 876-0047
    - GSK Investigational Site
  - Osaka, Japan, 530-0001
    - GSK Investigational Site
  - Osaka, Japan, 558-8558
    - GSK Investigational Site
  - Osaka, Japan, 591-8555
    - GSK Investigational Site
  - Shimane, Japan, 690-8556
    - GSK Investigational Site
  - Shimane, Japan, 690-8509
    - GSK Investigational Site
  - Tokyo, Japan, 103-0027
    - GSK Investigational Site
  - Tokyo, Japan, 103-0028
    - GSK Investigational Site
  - Tokyo, Japan, 194-0023
    - GSK Investigational Site
Kalkun
- - Ankara, Kalkun, 06500
    - GSK Investigational Site
  - Ankara, Kalkun, 06590
    - GSK Investigational Site
  - Ankara, Kalkun, 06280
    - GSK Investigational Site
  - Ankara, Kalkun, 06510
    - GSK Investigational Site
  - Ankara, Kalkun, 6030
    - GSK Investigational Site
  - Bursa, Kalkun, 16059
    - GSK Investigational Site
  - Istanbul, Kalkun, 34020
    - GSK Investigational Site
  - Istanbul, Kalkun, 34844
    - GSK Investigational Site
  - Istanbul, Kalkun, 34899
    - GSK Investigational Site
  - Istanbul, Kalkun, 61080
    - GSK Investigational Site
  - Kocaeli, Kalkun, 41380
    - GSK Investigational Site
  - Konya, Kalkun, 42080
    - GSK Investigational Site
  - Samsun, Kalkun, 55139
    - GSK Investigational Site
  - İstanbul, Kalkun, 34098
    - GSK Investigational Site
Kina
- - Baotou, Kina
    - GSK Investigational Site
  - Beijing, Kina, 100029
    - GSK Investigational Site
  - Beijing, Kina, 100050
    - GSK Investigational Site
  - Beijing, Kina, 100020
    - GSK Investigational Site
  - Beijing, Kina, 100144
    - GSK Investigational Site
  - Beijing, Kina, 100070
    - GSK Investigational Site
  - Bengbu, Kina, 233000
    - GSK Investigational Site
  - Changchun, Kina, 130012
    - GSK Investigational Site
  - Chengdu, Kina, 610041
    - GSK Investigational Site
  - Chongqing, Kina, 400038
    - GSK Investigational Site
  - Chongqing, Kina, 400016
    - GSK Investigational Site
  - Chongqing, Kina, 400042
    - GSK Investigational Site
  - Fu Zhou, Kina
    - GSK Investigational Site
  - Fuzhou, Kina, 350025
    - GSK Investigational Site
  - Guangxi, Kina, 530021
    - GSK Investigational Site
  - Guangzhou, Kina, 510080
    - GSK Investigational Site
  - Hangzhou, Kina, 310014
    - GSK Investigational Site
  - Hefei, Kina, 230001
    - GSK Investigational Site
  - Huai'an, Kina, 223300
    - GSK Investigational Site
  - Jiangyin, Kina
    - GSK Investigational Site
  - Luzhou, Kina
    - GSK Investigational Site
  - Nanchang, Kina, 330006
    - GSK Investigational Site
  - Nanjing, Kina, 210009
    - GSK Investigational Site
  - ShangHai, Kina, 200062
    - GSK Investigational Site
  - Shanghai, Kina, 200025
    - GSK Investigational Site
  - Shanghai, Kina, 200040
    - GSK Investigational Site
  - Shanghai, Kina, 200433
    - GSK Investigational Site
  - Shanghai, Kina, 200032
    - GSK Investigational Site
  - Shanghai, Kina, 200003
    - GSK Investigational Site
  - Shanghai, Kina, 200072
    - GSK Investigational Site
  - Tianjin, Kina, 300121
    - GSK Investigational Site
  - Wuxi, Kina, 214023
    - GSK Investigational Site
- Guangdong
  - Guangzhou, Guangdong, Kina, 510080
    - GSK Investigational Site
  - Guangzhou, Guangdong, Kina, 510515
    - GSK Investigational Site
  - Guangzhou, Guangdong, Kina, 510120
    - GSK Investigational Site
  - Shenzhen, Guangdong, Kina, 518020
    - GSK Investigational Site
  - Zhanjiang, Guangdong, Kina, 524001
    - GSK Investigational Site
- Guangxi
  - Nanning, Guangxi, Kina, 530021
    - GSK Investigational Site
- Hainan
  - Haikou, Hainan, Kina, 570311
    - GSK Investigational Site
  - Haikou, Hainan, Kina, 570001
    - GSK Investigational Site
  - Hohhot, Hainan, Kina, 010050
    - GSK Investigational Site
- Hebei
  - Shijiazhuang, Hebei, Kina, 050000
    - GSK Investigational Site
- Hubei
  - Wuhan, Hubei, Kina, 430060
    - GSK Investigational Site
- Inner Mongolia
  - Baotou, Inner Mongolia, Kina, 014010
    - GSK Investigational Site
- Liaoning
  - Shenyang, Liaoning, Kina, 110004
    - GSK Investigational Site
- Ningxia
  - Yinchuan, Ningxia, Kina, 750004
    - GSK Investigational Site
- Shaanxi
  - Xian, Shaanxi, Kina, 710032
    - GSK Investigational Site
- Shandong
  - Jinan, Shandong, Kina, 250033
    - GSK Investigational Site
- Shanxi
  - Taiyuan, Shanxi, Kina, 030001
    - GSK Investigational Site
- Sichuan
  - Chengdu, Sichuan, Kina, 610083
    - GSK Investigational Site
Korea, Republikken
- - Bucheon, Korea, Republikken, 420-717
    - GSK Investigational Site
  - Bucheon-Si, Gyeonggi-Do, Korea, Republikken, 420-021
    - GSK Investigational Site
  - Busan, Korea, Republikken, 602-715
    - GSK Investigational Site
  - Cheonan, Korea, Republikken, 330-721
    - GSK Investigational Site
  - Chonju-si, Korea, Republikken, 561-712
    - GSK Investigational Site
  - Daegu, Korea, Republikken, 705-717
    - GSK Investigational Site
  - Daejeon, Korea, Republikken, 301-721
    - GSK Investigational Site
  - Daejeon, Korea, Republikken, 301-723
    - GSK Investigational Site
  - Goyang-si, Korea, Republikken, 411706
    - GSK Investigational Site
  - Guri-si, Korea, Republikken, 471-701
    - GSK Investigational Site
  - Gwangju, Korea, Republikken, 501-757
    - GSK Investigational Site
  - Gyeonggi-do, Korea, Republikken, 410-719
    - GSK Investigational Site
  - Incheon, Korea, Republikken, 400-711
    - GSK Investigational Site
  - Incheon, Korea, Republikken, 403-720
    - GSK Investigational Site
  - Kangwon, Korea, Republikken, 200-722
    - GSK Investigational Site
  - Seongnam, Korea, Republikken, 463-712
    - GSK Investigational Site
  - Seoul, Korea, Republikken, 135-720
    - GSK Investigational Site
  - Seoul, Korea, Republikken, 136-705
    - GSK Investigational Site
  - Seoul, Korea, Republikken, 130-709
    - GSK Investigational Site
  - Seoul, Korea, Republikken, 152-703
    - GSK Investigational Site
  - Seoul, Korea, Republikken
    - GSK Investigational Site
  - Seoul, Korea, Republikken, 133--792
    - GSK Investigational Site
  - Seoul, Korea, Republikken, 158-710
    - GSK Investigational Site
  - Seoul, Korea, Republikken, 150-713
    - GSK Investigational Site
  - Seoul, Korea, Republikken, 130-872
    - GSK Investigational Site
  - Seoul, Korea, Republikken, 380-704
    - GSK Investigational Site
  - Seoul, Korea, Republikken, 110-746
    - GSK Investigational Site
  - Seoul, Korea, Republikken, 139-711
    - GSK Investigational Site
  - Seoul, Korea, Republikken, 100-030
    - GSK Investigational Site
  - Seoul, Korea, Republikken, 139-707
    - GSK Investigational Site
  - Seoul, Korea, Republikken, 140-887
    - GSK Investigational Site
  - Suwon, Gyeonggi-do, Korea, Republikken, 442-723
    - GSK Investigational Site
  - Uijeongbu, Gyeonggi-do, Korea, Republikken, 480-717
    - GSK Investigational Site
  - Ulsan, Korea, Republikken, 682-714
    - GSK Investigational Site
  - Wonju-si, Kanwon-do, Korea, Republikken, 220-701
    - GSK Investigational Site
Kroatien
- - Cakovec, Kroatien, 40000
    - GSK Investigational Site
  - Draganic, Kroatien, 47201
    - GSK Investigational Site
  - Hrasce Turopoljsko, Kroatien, 10020
    - GSK Investigational Site
  - Hreljin, Kroatien, 51226
    - GSK Investigational Site
  - Ivankovo, Kroatien, 32281
    - GSK Investigational Site
  - Karlovac, Kroatien, 47000
    - GSK Investigational Site
  - Klenovnik, Kroatien, 42244
    - GSK Investigational Site
  - Krapina, Kroatien, 49000
    - GSK Investigational Site
  - Kutina, Kroatien, 44320
    - GSK Investigational Site
  - Novi Marof, Kroatien, 42220
    - GSK Investigational Site
  - Osijek, Kroatien, 31000
    - GSK Investigational Site
  - Retkovci, Kroatien, 32282
    - GSK Investigational Site
  - Rijeka, Kroatien, 51000
    - GSK Investigational Site
  - Samobor, Kroatien, 10430
    - GSK Investigational Site
  - Senj, Kroatien, 53270
    - GSK Investigational Site
  - Sibenik, Kroatien, 22000
    - GSK Investigational Site
  - Sisak, Kroatien, 44000
    - GSK Investigational Site
  - Split, Kroatien, 21000
    - GSK Investigational Site
  - Strmec Samoborski, Kroatien, 10434
    - GSK Investigational Site
  - Stubicke toplice, Kroatien, 49244
    - GSK Investigational Site
  - Sukosan, Kroatien, 23206
    - GSK Investigational Site
  - Varazdin, Kroatien, 42000
    - GSK Investigational Site
  - Zabok, Kroatien, 49210
    - GSK Investigational Site
  - Zadar, Kroatien, 23000
    - GSK Investigational Site
  - Zagreb, Kroatien, 10000
    - GSK Investigational Site
Letland
- - Balvi, Letland, LV - 4501
    - GSK Investigational Site
  - Daugavpils, Letland, LA-5403
    - GSK Investigational Site
  - Daugavpils, Letland, LV5410
    - GSK Investigational Site
  - Jekabpils, Letland, LV 5201
    - GSK Investigational Site
  - Jelgava, Letland, LV - 3001
    - GSK Investigational Site
  - Jurmala, Letland, LV-2010
    - GSK Investigational Site
  - Kraslava, Letland, LV - 5601
    - GSK Investigational Site
  - Kuldiga, Letland, LV - 3301
    - GSK Investigational Site
  - Liepaja, Letland, LV 3414
    - GSK Investigational Site
  - Ogre, Letland, LV - 5001
    - GSK Investigational Site
  - Riga, Letland, LV 1002
    - GSK Investigational Site
  - Riga, Letland, LV-1010
    - GSK Investigational Site
  - Riga, Letland, LV 1003
    - GSK Investigational Site
  - Riga, Letland, LV1001
    - GSK Investigational Site
  - Riga, Letland, LV1038
    - GSK Investigational Site
  - Talsi, Letland, LV - 3201
    - GSK Investigational Site
  - Tukums, Letland, LV - 3101
    - GSK Investigational Site
  - Valmiera, Letland, LV-4201
    - GSK Investigational Site
  - Ventspils, Letland, LV3601
    - GSK Investigational Site
Makedonien, Den Tidligere Jugoslaviske Republik
- - Bitola, Makedonien, Den Tidligere Jugoslaviske Republik, 7000
    - GSK Investigational Site
  - Gostivar, Makedonien, Den Tidligere Jugoslaviske Republik, 1230
    - GSK Investigational Site
  - Ohrid, Makedonien, Den Tidligere Jugoslaviske Republik, 6000
    - GSK Investigational Site
  - Prilep, Makedonien, Den Tidligere Jugoslaviske Republik, 7500
    - GSK Investigational Site
  - Shtip, Makedonien, Den Tidligere Jugoslaviske Republik, 2000
    - GSK Investigational Site
  - Skopje, Makedonien, Den Tidligere Jugoslaviske Republik, 1000
    - GSK Investigational Site
  - Strumica, Makedonien, Den Tidligere Jugoslaviske Republik, 2400
    - GSK Investigational Site
  - Veles, Makedonien, Den Tidligere Jugoslaviske Republik, 1400
    - GSK Investigational Site
Malaysia
- - Johor Bahru, Malaysia, 80100
    - GSK Investigational Site
  - Kuala Lumpur, Malaysia, 50590
    - GSK Investigational Site
  - Kuala Pilah, Malaysia, 72000
    - GSK Investigational Site
  - Kuching, Malaysia, 93586
    - GSK Investigational Site
  - Selangor, Malaysia, 68100
    - GSK Investigational Site
  - Sibu, Malaysia, 96000
    - GSK Investigational Site
  - Sungai Petani, Kedah, Malaysia, 08000
    - GSK Investigational Site
  - Taiping Perak, Malaysia, 34000
    - GSK Investigational Site
Mexico
- - Aguascalientes, Mexico, 20127
    - GSK Investigational Site
  - Chihuahua, Mexico, 31203
    - GSK Investigational Site
  - Chihuahua, Mexico, 31238
    - GSK Investigational Site
  - Guadalajara, Mexico, 44670
    - GSK Investigational Site
  - Hidalgo, Mexico, 42070
    - GSK Investigational Site
  - Merida, Mexico, 97000
    - GSK Investigational Site
  - Mexico D.F, Mexico, 6700
    - GSK Investigational Site
  - Monterrey, Mexico, 64060
    - GSK Investigational Site
  - México DF, Mexico, 14050
    - GSK Investigational Site
  - San luis Potosí, Mexico, 78090
    - GSK Investigational Site
- Estado De México
  - Cuautitlan Izcalli, Estado De México, Mexico, 54769
    - GSK Investigational Site
- Jalisco
  - Guadalajara, Jalisco, Mexico, 44500
    - GSK Investigational Site
  - Zapopan, Jalisco, Mexico, 45040
    - GSK Investigational Site
- Michoacán
  - Morelia, Michoacán, Mexico, C.P. 58249
    - GSK Investigational Site
- Morelos
  - Cuernavaca, Morelos, Mexico, 62350
    - GSK Investigational Site
- Nuevo León
  - Monterrey, Nuevo León, Mexico, 64460
    - GSK Investigational Site
  - Monterrey, Nuevo León, Mexico, 64710
    - GSK Investigational Site
- Sonora
  - Hermosillo, Sonora, Mexico, 83000
    - GSK Investigational Site
Polen
- - Bialystok, Polen, 15-044
    - GSK Investigational Site
  - Bialystok, Polen, 15-003
    - GSK Investigational Site
  - Bielsko-Biala, Polen, 43-300
    - GSK Investigational Site
  - Bielsko-Biala, Polen, 43-316
    - GSK Investigational Site
  - Bienkowka, Polen, 34-212
    - GSK Investigational Site
  - Bydgoszcz, Polen, 85-681
    - GSK Investigational Site
  - Bydgoszcz, Polen, 85-863
    - GSK Investigational Site
  - Chelmza, Polen, 87-140
    - GSK Investigational Site
  - Chodziez, Polen, 64-800
    - GSK Investigational Site
  - Chorzow, Polen, 41-500
    - GSK Investigational Site
  - Choszczno, Polen, 73-200
    - GSK Investigational Site
  - Czestochowa, Polen, 42-200
    - GSK Investigational Site
  - Dabrowa Gornicza, Polen, 41-300
    - GSK Investigational Site
  - Dzialdowo, Polen, 13-200
    - GSK Investigational Site
  - Elblag, Polen, 82-300
    - GSK Investigational Site
  - Gdansk, Polen, 80-405
    - GSK Investigational Site
  - Gdansk, Polen, 80-286
    - GSK Investigational Site
  - Gdansk, Polen, 80-433
    - GSK Investigational Site
  - Gdynia, Polen, 81-384
    - GSK Investigational Site
  - Gorzow Wielkopolski, Polen, 66-400
    - GSK Investigational Site
  - Grudziadz, Polen, 86-300
    - GSK Investigational Site
  - Ilawa, Polen, 14-200
    - GSK Investigational Site
  - Inowroclaw, Polen, 88-100
    - GSK Investigational Site
  - Izabelin, Polen, 05-080
    - GSK Investigational Site
  - Jelenia Gora, Polen, 58-506
    - GSK Investigational Site
  - Karpacz, Polen, 58-540
    - GSK Investigational Site
  - Katowice, Polen, 40-040
    - GSK Investigational Site
  - Katowice, Polen, 40-954
    - GSK Investigational Site
  - Kielce, Polen, 25-734
    - GSK Investigational Site
  - Kielce, Polen, 25-030
    - GSK Investigational Site
  - Kielce, Polen, 25-365
    - GSK Investigational Site
  - Krakow, Polen, 31-024
    - GSK Investigational Site
  - Krakow, Polen, 31-530
    - GSK Investigational Site
  - Krakow, Polen, 31-637
    - GSK Investigational Site
  - Krakow, Polen, 31-455
    - GSK Investigational Site
  - Krakow, Polen, 31-567
    - GSK Investigational Site
  - Krakow, Polen, 31-913
    - GSK Investigational Site
  - Krotoszyn, Polen, 63-700
    - GSK Investigational Site
  - Ksawerow, Polen, 95-054
    - GSK Investigational Site
  - Kutno, Polen, 99-300
    - GSK Investigational Site
  - Libiaz, Polen, 32-590
    - GSK Investigational Site
  - Lodz, Polen, 90-153
    - GSK Investigational Site
  - Lodz, Polen, 93-329
    - GSK Investigational Site
  - Lodz, Polen, 90-203
    - GSK Investigational Site
  - Lodz, Polen, 90-302
    - GSK Investigational Site
  - Lodz, Polen, 90-430
    - GSK Investigational Site
  - Lodz, Polen, 91-849
    - GSK Investigational Site
  - Lodz, Polen, 92-107
    - GSK Investigational Site
  - Lodz, Polen, 92-215
    - GSK Investigational Site
  - Lodz, Polen, 93-113
    - GSK Investigational Site
  - Lodz, Polen, 94-050
    - GSK Investigational Site
  - Lublin, Polen, 20-093
    - GSK Investigational Site
  - Lublin, Polen, 20-718
    - GSK Investigational Site
  - Lublin, Polen, 20-552
    - GSK Investigational Site
  - Olawa, Polen, 55-200
    - GSK Investigational Site
  - Olsztyn, Polen, 10-357
    - GSK Investigational Site
  - Ostrow Wilekopolski, Polen, 63-400
    - GSK Investigational Site
  - Ostrowiec Swietokrzyski, Polen, 27-400
    - GSK Investigational Site
  - Piaseczno, Polen, 05-500
    - GSK Investigational Site
  - Pila, Polen, 64-920
    - GSK Investigational Site
  - Plock, Polen, 09-402
    - GSK Investigational Site
  - Police, Polen, 72-010
    - GSK Investigational Site
  - Poznan, Polen, 60-214
    - GSK Investigational Site
  - Poznan, Polen, 60-569
    - GSK Investigational Site
  - Poznan, Polen, 60-773
    - GSK Investigational Site
  - Poznan, Polen, 60-823
    - GSK Investigational Site
  - Ruda Slaska, Polen, 41-709
    - GSK Investigational Site
  - Rudka, Polen, 05-320
    - GSK Investigational Site
  - Rzeszow, Polen, 35-301
    - GSK Investigational Site
  - Skarzysko-Kamienna, Polen, 26-110
    - GSK Investigational Site
  - Skierniewice, Polen, 96-100
    - GSK Investigational Site
  - Slupsk, Polen, 76-200
    - GSK Investigational Site
  - Sopot, Polen, 81- 717
    - GSK Investigational Site
  - Swidnik, Polen, 21-040
    - GSK Investigational Site
  - Szczecin, Polen, 70-111
    - GSK Investigational Site
  - Szczecin, Polen, 71-124
    - GSK Investigational Site
  - Tarnow, Polen, 33-100
    - GSK Investigational Site
  - Tczew, Polen, 83-110
    - GSK Investigational Site
  - Torun, Polen, 87100
    - GSK Investigational Site
  - Warszawa, Polen, 01-138
    - GSK Investigational Site
  - Warszawa, Polen, 01-192
    - GSK Investigational Site
  - Warszawa, Polen, 01-868
    - GSK Investigational Site
  - Warszawa, Polen, 01-157
    - GSK Investigational Site
  - Wloclawek, Polen, 87-800
    - GSK Investigational Site
  - Wloszczowa, Polen, 29-100
    - GSK Investigational Site
  - Wodzislaw Slaski, Polen, 44-300
    - GSK Investigational Site
  - Wroclaw, Polen, 54-239
    - GSK Investigational Site
  - Wroclaw, Polen, 50-044
    - GSK Investigational Site
  - Wroclaw, Polen, 50-088
    - GSK Investigational Site
  - Wroclaw, Polen, 53-301
    - GSK Investigational Site
  - Wroclaw, Polen, 53-439
    - GSK Investigational Site
  - Zabrze, Polen, 41-800
    - GSK Investigational Site
  - Zabrze, Polen, 41-807
    - GSK Investigational Site
  - Zgierz, Polen, 95-100
    - GSK Investigational Site
  - Łęczyca, Polen, 99-100
    - GSK Investigational Site
Rumænien
- - Arad, Rumænien, 310013
    - GSK Investigational Site
  - Bacau, Rumænien, 600252
    - GSK Investigational Site
  - Bragadiru, Rumænien, 077025
    - GSK Investigational Site
  - Brasov, Rumænien, 500283
    - GSK Investigational Site
  - Brasov, Rumænien, 500086
    - GSK Investigational Site
  - Bucarest, Rumænien, 050159
    - GSK Investigational Site
  - Bucharest, Rumænien, 050159
    - GSK Investigational Site
  - Bucharest, Rumænien, 020125
    - GSK Investigational Site
  - Bucharest, Rumænien, 011794
    - GSK Investigational Site
  - Bucharest, Rumænien, 030303
    - GSK Investigational Site
  - Bucuresti, Rumænien, 022328
    - GSK Investigational Site
  - Bucuresti, Rumænien, 030303
    - GSK Investigational Site
  - Bucuresti, Rumænien, 011025
    - GSK Investigational Site
  - Bucuresti, Rumænien, 012384
    - GSK Investigational Site
  - Bucuresti, Rumænien, 014461
    - GSK Investigational Site
  - Bucuresti, Rumænien, 020475
    - GSK Investigational Site
  - Bucuresti, Rumænien, 021659
    - GSK Investigational Site
  - Bucuresti, Rumænien, 040206
    - GSK Investigational Site
  - Bucuresti, Rumænien, 050159
    - GSK Investigational Site
  - Bucuresti, Rumænien, 050554
    - GSK Investigational Site
  - Bucuresti, Rumænien, 050722
    - GSK Investigational Site
  - Bucuresti, Rumænien, 10825
    - GSK Investigational Site
  - Campulung Muscel, Rumænien, 115100
    - GSK Investigational Site
  - Cluj-Napoca, Rumænien, 400371
    - GSK Investigational Site
  - Cluj-Napoca, Rumænien, 400352
    - GSK Investigational Site
  - Codlea, Rumænien, 505100
    - GSK Investigational Site
  - Constanta, Rumænien, 900002
    - GSK Investigational Site
  - Constanta, Rumænien, 900004
    - GSK Investigational Site
  - Deva, Rumænien, 330084
    - GSK Investigational Site
  - Iasi, Rumænien, 700503
    - GSK Investigational Site
  - Iasi, Rumænien, 700141
    - GSK Investigational Site
  - Iasi, Rumænien, 700381
    - GSK Investigational Site
  - Iasi, Rumænien, 700656
    - GSK Investigational Site
  - Pitesti, Rumænien, 110084
    - GSK Investigational Site
  - Pitesti, Rumænien, 110283
    - GSK Investigational Site
  - Ploiesti, Rumænien, 100184
    - GSK Investigational Site
  - Ramnicu Valcea, Rumænien, 240564
    - GSK Investigational Site
  - Suceava, Rumænien, 720284
    - GSK Investigational Site
  - Targu-Mures, Rumænien, 540142
    - GSK Investigational Site
  - Timisoara, Rumænien, 300310
    - GSK Investigational Site
  - Timisoara, Rumænien, 300736
    - GSK Investigational Site
Serbien
- - Belgrade, Serbien, 11000
    - GSK Investigational Site
  - Belgrade, Serbien, 11080
    - GSK Investigational Site
  - Cacak, Serbien, 32000
    - GSK Investigational Site
  - Kragujevac, Serbien, 34000
    - GSK Investigational Site
  - Nis, Serbien, 18000
    - GSK Investigational Site
  - Sombor, Serbien, 25000
    - GSK Investigational Site
  - Sremska Kamenica, Serbien, 21204
    - GSK Investigational Site
  - Valjevo, Serbien, 14000
    - GSK Investigational Site
Slovakiet
- - Bratislava, Slovakiet, 851 01
    - GSK Investigational Site
  - Bratislava, Slovakiet, 841 08
    - GSK Investigational Site
  - Bratislava, Slovakiet, 821 06
    - GSK Investigational Site
  - Bratislava, Slovakiet, 841 04
    - GSK Investigational Site
  - Kosice, Slovakiet, 040 01
    - GSK Investigational Site
  - Kralovsky Chlmec, Slovakiet, 077 01
    - GSK Investigational Site
  - Nove Zamky, Slovakiet, 940 01
    - GSK Investigational Site
  - Presov, Slovakiet, 080 01
    - GSK Investigational Site
  - Presov, Slovakiet, 081 81
    - GSK Investigational Site
  - Spisska Nova Ves, Slovakiet, 052 01
    - GSK Investigational Site
  - Sturovo, Slovakiet, 943 01
    - GSK Investigational Site
  - Trnava, Slovakiet, 917 01
    - GSK Investigational Site
  - Vrable, Slovakiet, 952 01
    - GSK Investigational Site
Spanien
- - Badalona, Spanien, 08916
    - GSK Investigational Site
  - Barcelona, Spanien, 08025
    - GSK Investigational Site
  - Barcelona, Spanien, 08036
    - GSK Investigational Site
  - Barcelona, Spanien, 08022
    - GSK Investigational Site
  - Barcelona, Spanien, 08041
    - GSK Investigational Site
  - Benidorm, Spanien, 03501
    - GSK Investigational Site
  - Canet De Mar - Barcelona, Spanien, 08360
    - GSK Investigational Site
  - Galdakano, Spanien, 48960
    - GSK Investigational Site
  - Illescas-Toledo, Spanien, 45200
    - GSK Investigational Site
  - Jerez de la Frontera, Spanien, 11407
    - GSK Investigational Site
  - L'Hospitalet de Llobregat, Spanien, 08907
    - GSK Investigational Site
  - Madrid, Spanien, 28040
    - GSK Investigational Site
  - Madrid, Spanien, 28046
    - GSK Investigational Site
  - Mataró, Spanien, 08303
    - GSK Investigational Site
  - Oviedo, Spanien, 33006
    - GSK Investigational Site
  - Palma de Mallorca, Spanien, 07010
    - GSK Investigational Site
  - Pamplona, Spanien, 31008
    - GSK Investigational Site
  - Pozuelo De Alarcón/Madrid, Spanien, 28223
    - GSK Investigational Site
  - Sabadell (Barcelona), Spanien, 08208
    - GSK Investigational Site
  - Sagunto/Valencia, Spanien, 46520
    - GSK Investigational Site
  - Sant Boi de Llobregat, Spanien, 08830
    - GSK Investigational Site
  - Santa Coloma de Gramenet, Spanien, 08921
    - GSK Investigational Site
  - Santiago de Compostela, Spanien, 15706
    - GSK Investigational Site
  - Torrelavega, Spanien, 39300
    - GSK Investigational Site
  - Valencia, Spanien, 46017
    - GSK Investigational Site
  - Vic (Barcelona), Spanien, 08500
    - GSK Investigational Site
Sydafrika
- - Benoni, Sydafrika, 1501
    - GSK Investigational Site
  - Bloemfontein, Sydafrika, 9301
    - GSK Investigational Site
  - Cape Town, Sydafrika, 7500
    - GSK Investigational Site
  - Cape Town, Sydafrika, 7700
    - GSK Investigational Site
  - Cape Town, Sydafrika, 7572
    - GSK Investigational Site
  - Cape Town, Sydafrika, 8001
    - GSK Investigational Site
  - Cape Town, Sydafrika, 7441
    - GSK Investigational Site
  - CapeTown, Sydafrika, 7764
    - GSK Investigational Site
  - Durban, Sydafrika, 4001
    - GSK Investigational Site
  - Durban, Sydafrika, 4071
    - GSK Investigational Site
  - Gatesville, Sydafrika, 7764
    - GSK Investigational Site
  - Johannesburg, Sydafrika, 1686
    - GSK Investigational Site
  - Korsten, Sydafrika, 6014
    - GSK Investigational Site
  - Lynnwood Ridge, Sydafrika, 0014
    - GSK Investigational Site
  - Mowbray, Sydafrika, 7700
    - GSK Investigational Site
  - Paarl, Sydafrika, 7646
    - GSK Investigational Site
  - Panorama, Sydafrika, 7500
    - GSK Investigational Site
  - Potchefstroom, Sydafrika, 2531
    - GSK Investigational Site
  - Pretoria, Sydafrika, 0002
    - GSK Investigational Site
  - Pretoria, Sydafrika, 0022
    - GSK Investigational Site
  - Roodepoort, Sydafrika, 1724
    - GSK Investigational Site
  - Rooihuiskraal, Sydafrika, 158
    - GSK Investigational Site
  - Somerset West, Sydafrika, 7130
    - GSK Investigational Site
  - Thabazimbi, Sydafrika, 0380
    - GSK Investigational Site
  - Tygerberg, Sydafrika, 7505
    - GSK Investigational Site
  - Voorspoed, Sydafrika, 9459
    - GSK Investigational Site
- Gauteng
  - Benoni, Gauteng, Sydafrika, 1501
    - GSK Investigational Site
  - Boksburg, Gauteng, Sydafrika, 1459
    - GSK Investigational Site
  - Meyerspark, Gauteng, Sydafrika, 0184
    - GSK Investigational Site
  - Morningside, Gauteng, Sydafrika, 2057
    - GSK Investigational Site
  - Pretoria, Gauteng, Sydafrika, 0084
    - GSK Investigational Site
  - Pretoria, Gauteng, Sydafrika, 0183
    - GSK Investigational Site
  - Pretoria, Gauteng, Sydafrika, 0041
    - GSK Investigational Site
  - Pretoria, Gauteng, Sydafrika, 0181
    - GSK Investigational Site
  - Thaba Tshwane, Gauteng, Sydafrika, 0143
    - GSK Investigational Site
- KwaZulu- Natal
  - Dundee, KwaZulu- Natal, Sydafrika, 3000
    - GSK Investigational Site
- Mpumalanga
  - Middelburg, Mpumalanga, Sydafrika, 1055
    - GSK Investigational Site
Taiwan
- - Changhua, Taiwan, 500
    - GSK Investigational Site
  - Chia-Yi, Taiwan, 613
    - GSK Investigational Site
  - Kaohsiung, Taiwan, 807
    - GSK Investigational Site
  - Kaohsiung Hsien, Taiwan, 833
    - GSK Investigational Site
  - Keelung, Taiwan, 20401
    - GSK Investigational Site
  - LinKou, Taiwan, 333
    - GSK Investigational Site
  - Taichung, Taiwan, 404
    - GSK Investigational Site
  - Taichung, Taiwan, 40705
    - GSK Investigational Site
  - Taichung, Taiwan, 40201
    - GSK Investigational Site
  - Taichung, Taiwan, 433
    - GSK Investigational Site
  - Taichung, Taiwan, 437
    - GSK Investigational Site
  - Tainan, Taiwan, 704
    - GSK Investigational Site
  - Taipei, Taiwan
    - GSK Investigational Site
  - Taipei, Taiwan, 220
    - GSK Investigational Site
  - Taipei, Taiwan, 106
    - GSK Investigational Site
  - Taipei, Taiwan, 115
    - GSK Investigational Site
  - Taipei, Taiwan, 235
    - GSK Investigational Site
  - Yung Kang City, Taiwan, 71044
    - GSK Investigational Site
Thailand
- - Bangkok, Thailand, 10400
    - GSK Investigational Site
  - Bangkok, Thailand, 10330
    - GSK Investigational Site
  - Bangkok, Thailand, 10700
    - GSK Investigational Site
  - Bangkok, Thailand, 10600
    - GSK Investigational Site
  - Bangkok, Thailand, 10220
    - GSK Investigational Site
  - Chiangmai, Thailand, 50200
    - GSK Investigational Site
  - Chiangrai, Thailand, 57000
    - GSK Investigational Site
  - Khon Kaen, Thailand, 40002
    - GSK Investigational Site
  - Mae Rim, Chiang Mai, Thailand, 50180
    - GSK Investigational Site
  - Muang, Thailand, 11000
    - GSK Investigational Site
  - Muang Phitsanulok, Thailand, 53000
    - GSK Investigational Site
  - Nakhon Ratchasima, Thailand, 30000
    - GSK Investigational Site
  - Phitsanulok, Thailand, 65000
    - GSK Investigational Site
  - Songkla, Thailand, 90110
    - GSK Investigational Site
Tjekkiet
- - Benesov, Tjekkiet, 256 01
    - GSK Investigational Site
  - Beroun, Tjekkiet, 266 01
    - GSK Investigational Site
  - Brno, Tjekkiet, 612 00
    - GSK Investigational Site
  - Havlickuv brod, Tjekkiet, 580 01
    - GSK Investigational Site
  - Hlucin, Tjekkiet, 748 01
    - GSK Investigational Site
  - Holesov, Tjekkiet, 769 01
    - GSK Investigational Site
  - Jaromer, Tjekkiet, 551 01
    - GSK Investigational Site
  - Jindrichuv Hradec, Tjekkiet, 377 01
    - GSK Investigational Site
  - Kolin, Tjekkiet, 280 00
    - GSK Investigational Site
  - Kralupy nad Vltavou, Tjekkiet, 278 01
    - GSK Investigational Site
  - Kromeriz, Tjekkiet, 767 01
    - GSK Investigational Site
  - Liberec, Tjekkiet, 460 01
    - GSK Investigational Site
  - Melnik, Tjekkiet, 276 01
    - GSK Investigational Site
  - Moravsky Krumlov, Tjekkiet, 672 01
    - GSK Investigational Site
  - Neratovice, Tjekkiet, 277 11
    - GSK Investigational Site
  - Novy Jicin, Tjekkiet, 741 01
    - GSK Investigational Site
  - Ostrava, Tjekkiet, 72880
    - GSK Investigational Site
  - Ostrava - Belsky les, Tjekkiet, 700 30
    - GSK Investigational Site
  - Ostrava - Poruba, Tjekkiet, 70868
    - GSK Investigational Site
  - Plzen, Tjekkiet, 301 00
    - GSK Investigational Site
  - Plzen, Tjekkiet, 323 00
    - GSK Investigational Site
  - Praha 1, Tjekkiet, 110 00
    - GSK Investigational Site
  - Praha 13, Tjekkiet, 158 00
    - GSK Investigational Site
  - Praha 17, Tjekkiet, 163 00
    - GSK Investigational Site
  - Praha 3, Tjekkiet, 130 00
    - GSK Investigational Site
  - Praha 4, Tjekkiet, 140 46
    - GSK Investigational Site
  - Praha 4, Tjekkiet, 140 00
    - GSK Investigational Site
  - Praha 5, Tjekkiet, 150 00
    - GSK Investigational Site
  - Praha 6, Tjekkiet, 169 00
    - GSK Investigational Site
  - Rokycany, Tjekkiet, 337 01
    - GSK Investigational Site
  - Rudna, Tjekkiet, 252 19
    - GSK Investigational Site
  - Strakonice, Tjekkiet, 386 01
    - GSK Investigational Site
  - Strakonice, Tjekkiet, 386 29
    - GSK Investigational Site
  - Svitavy, Tjekkiet, 568 25
    - GSK Investigational Site
  - Tremosna, Tjekkiet, 330 11
    - GSK Investigational Site
  - Usti Nad Labem - Klise, Tjekkiet, 400 01
    - GSK Investigational Site
  - Zatec, Tjekkiet, 438 01
    - GSK Investigational Site
Tyskland
- - Berlin, Tyskland, 13086
    - GSK Investigational Site
  - Berlin, Tyskland, 10717
    - GSK Investigational Site
  - Berlin, Tyskland, 13125
    - GSK Investigational Site
  - Berlin, Tyskland, 10787
    - GSK Investigational Site
  - Berlin, Tyskland, 10789
    - GSK Investigational Site
  - Berlin, Tyskland, 12627
    - GSK Investigational Site
  - Berlin, Tyskland, 10969
    - GSK Investigational Site
  - Berlin, Tyskland, 12203
    - GSK Investigational Site
  - Berlin, Tyskland, 13507
    - GSK Investigational Site
  - Berlin, Tyskland, 13156
    - GSK Investigational Site
  - Berlin, Tyskland, 12687
    - GSK Investigational Site
  - Berlin, Tyskland, 12043
    - GSK Investigational Site
  - Berlin, Tyskland, 12099
    - GSK Investigational Site
  - Berlin, Tyskland, 12165
    - GSK Investigational Site
  - Hamburg, Tyskland, 22291
    - GSK Investigational Site
  - Hamburg, Tyskland, 22763
    - GSK Investigational Site
  - München, Tyskland, 81677
    - GSK Investigational Site
- Baden-Wuerttemberg
  - Bruchsal, Baden-Wuerttemberg, Tyskland, 76646
    - GSK Investigational Site
  - Deggingen, Baden-Wuerttemberg, Tyskland, 73326
    - GSK Investigational Site
  - Ettlingen, Baden-Wuerttemberg, Tyskland, 76275
    - GSK Investigational Site
  - Frankfurt, Baden-Wuerttemberg, Tyskland, 60596
    - GSK Investigational Site
  - Karlsruhe, Baden-Wuerttemberg, Tyskland, 76227
    - GSK Investigational Site
- Bayern
  - Aschaffenburg, Bayern, Tyskland, 63739
    - GSK Investigational Site
  - Augsburg, Bayern, Tyskland, 86150
    - GSK Investigational Site
  - Augsburg, Bayern, Tyskland, 86156
    - GSK Investigational Site
  - Bad Woerrishofen, Bayern, Tyskland, 86825
    - GSK Investigational Site
  - Feldkirchen, Bayern, Tyskland, 83620
    - GSK Investigational Site
  - Fuerth, Bayern, Tyskland, 90762
    - GSK Investigational Site
  - Gauting, Bayern, Tyskland, 82131
    - GSK Investigational Site
  - Hoechstadt, Bayern, Tyskland, 91315
    - GSK Investigational Site
  - Landsberg, Bayern, Tyskland, 86899
    - GSK Investigational Site
  - Muenchen, Bayern, Tyskland, 80335
    - GSK Investigational Site
  - Vilshofen, Bayern, Tyskland, 94474
    - GSK Investigational Site
  - Weissenhorn, Bayern, Tyskland, 89264
    - GSK Investigational Site
- Brandenburg
  - Cottbus, Brandenburg, Tyskland, 03050
    - GSK Investigational Site
  - Potsdam, Brandenburg, Tyskland, 14478
    - GSK Investigational Site
  - Ruedersdorf, Brandenburg, Tyskland, 15562
    - GSK Investigational Site
- Hessen
  - Bensheim, Hessen, Tyskland, 64625
    - GSK Investigational Site
  - Darmstadt, Hessen, Tyskland, 64287
    - GSK Investigational Site
  - Kassel, Hessen, Tyskland, 34121
    - GSK Investigational Site
  - Marburg, Hessen, Tyskland, 35037
    - GSK Investigational Site
- Niedersachsen
  - Goettingen, Niedersachsen, Tyskland, 37081
    - GSK Investigational Site
  - Hannover, Niedersachsen, Tyskland, 30159
    - GSK Investigational Site
  - Papenburg, Niedersachsen, Tyskland, 26871
    - GSK Investigational Site
  - Stuhr, Niedersachsen, Tyskland, 28816
    - GSK Investigational Site
  - Wardenburg, Niedersachsen, Tyskland, 26203
    - GSK Investigational Site
- Nordrhein-Westfalen
  - Bergisch Gladbach, Nordrhein-Westfalen, Tyskland, 51429
    - GSK Investigational Site
  - Bochum, Nordrhein-Westfalen, Tyskland, 44787
    - GSK Investigational Site
  - Bonn, Nordrhein-Westfalen, Tyskland, 53119
    - GSK Investigational Site
  - Bonn, Nordrhein-Westfalen, Tyskland, 53123
    - GSK Investigational Site
  - Dortmund, Nordrhein-Westfalen, Tyskland, 44263
    - GSK Investigational Site
  - Dueren, Nordrhein-Westfalen, Tyskland, 52349
    - GSK Investigational Site
  - Essen, Nordrhein-Westfalen, Tyskland, 45355
    - GSK Investigational Site
  - Essen, Nordrhein-Westfalen, Tyskland, 45136
    - GSK Investigational Site
  - Gelsenkirchen, Nordrhein-Westfalen, Tyskland, 45879
    - GSK Investigational Site
  - Hagen, Nordrhein-Westfalen, Tyskland, 58089
    - GSK Investigational Site
  - Hagen, Nordrhein-Westfalen, Tyskland, 58095
    - GSK Investigational Site
  - Harsewinkel, Nordrhein-Westfalen, Tyskland, 33428
    - GSK Investigational Site
  - Koeln, Nordrhein-Westfalen, Tyskland, 51069
    - GSK Investigational Site
  - Neuss, Nordrhein-Westfalen, Tyskland, 41462
    - GSK Investigational Site
  - Solingen, Nordrhein-Westfalen, Tyskland, 42651
    - GSK Investigational Site
- Rheinland-Pfalz
  - Foehren, Rheinland-Pfalz, Tyskland, 54343
    - GSK Investigational Site
  - Ingelheim, Rheinland-Pfalz, Tyskland, 55218
    - GSK Investigational Site
  - Mainz, Rheinland-Pfalz, Tyskland, 55116
    - GSK Investigational Site
  - Neuwied, Rheinland-Pfalz, Tyskland, 56564
    - GSK Investigational Site
  - Rhaunen, Rheinland-Pfalz, Tyskland, 55624
    - GSK Investigational Site
- Sachsen
  - Dresden, Sachsen, Tyskland, 01307
    - GSK Investigational Site
  - Dresden, Sachsen, Tyskland, 01067
    - GSK Investigational Site
  - Goerlitz, Sachsen, Tyskland, 02826
    - GSK Investigational Site
  - Leipzg, Sachsen, Tyskland, 04109
    - GSK Investigational Site
  - Leipzig, Sachsen, Tyskland, 04275
    - GSK Investigational Site
  - Leipzig, Sachsen, Tyskland, 04357
    - GSK Investigational Site
  - Leipzig, Sachsen, Tyskland, 04103
    - GSK Investigational Site
  - Leipzig, Sachsen, Tyskland, 04157
    - GSK Investigational Site
  - Riesa, Sachsen, Tyskland, 01587
    - GSK Investigational Site
- Sachsen-Anhalt
  - Magdeburg, Sachsen-Anhalt, Tyskland, 39104
    - GSK Investigational Site
  - Zerbst, Sachsen-Anhalt, Tyskland, 39261
    - GSK Investigational Site
- Schleswig-Holstein
  - Reinfeld, Schleswig-Holstein, Tyskland, 23858
    - GSK Investigational Site
  - Schleswig, Schleswig-Holstein, Tyskland, 24837
    - GSK Investigational Site
- Thueringen
  - Jena, Thueringen, Tyskland, 07740
    - GSK Investigational Site
Ukraine
- - Alupka, Ukraine, 98676
    - GSK Investigational Site
  - Cherkassy, Ukraine, 18009
    - GSK Investigational Site
  - Chernihiv, Ukraine, 14034
    - GSK Investigational Site
  - Chernivtsi, Ukraine, 58022
    - GSK Investigational Site
  - Dnipropetrovsk, Ukraine, 49074
    - GSK Investigational Site
  - Dnipropetrovsk, Ukraine, 49027
    - GSK Investigational Site
  - Dnipropetrovsk, Ukraine, 49102
    - GSK Investigational Site
  - Dnipropetrovsk, Ukraine, 49005
    - GSK Investigational Site
  - Dnipropetrovsk, Ukraine, 49064
    - GSK Investigational Site
  - Donetsk, Ukraine, 83003
    - GSK Investigational Site
  - Donetsk, Ukraine, 83114
    - GSK Investigational Site
  - Donetsk, Ukraine, 83045
    - GSK Investigational Site
  - Donetsk, Ukraine, 83059
    - GSK Investigational Site
  - Ivano-Frankivsk, Ukraine, 76008
    - GSK Investigational Site
  - Ivano-Frankivsk, Ukraine, 76018
    - GSK Investigational Site
  - Ivano-Frankivsk, Ukraine, 76005
    - GSK Investigational Site
  - Kharkiv, Ukraine, 61124
    - GSK Investigational Site
  - Kharkiv, Ukraine, 61039
    - GSK Investigational Site
  - Kharkiv, Ukraine, 61002
    - GSK Investigational Site
  - Kharkiv, Ukraine, 61018
    - GSK Investigational Site
  - Kharkiv, Ukraine, 61022
    - GSK Investigational Site
  - Kharkiv, Ukraine, 61001
    - GSK Investigational Site
  - Kharkiv, Ukraine, 61046
    - GSK Investigational Site
  - Kharkiv, Ukraine, 61103
    - GSK Investigational Site
  - Kharkiv, Ukraine, 61157
    - GSK Investigational Site
  - Kherson, Ukraine, 73000
    - GSK Investigational Site
  - Kiev, Ukraine, 03680
    - GSK Investigational Site
  - Kiev, Ukraine, 02660
    - GSK Investigational Site
  - Kryvyi Rig, Ukraine, 50096
    - GSK Investigational Site
  - Kyiv, Ukraine, 03680
    - GSK Investigational Site
  - Kyiv, Ukraine, 03038
    - GSK Investigational Site
  - Kyiv, Ukraine, 03049
    - GSK Investigational Site
  - Kyiv, Ukraine, 04114
    - GSK Investigational Site
  - Kyiv, Ukraine, 04201
    - GSK Investigational Site
  - Kyiv, Ukraine, 03179
    - GSK Investigational Site
  - Kyiv, Ukraine, 1680
    - GSK Investigational Site
  - Kyiv, Ukraine, 4050
    - GSK Investigational Site
  - Kyiv, Ukraine, 4107
    - GSK Investigational Site
  - Lutsk, Ukraine, 43024
    - GSK Investigational Site
  - Lviv, Ukraine, 79010
    - GSK Investigational Site
  - Lviv, Ukraine, 79015
    - GSK Investigational Site
  - Mykolaiv, Ukraine, 54003
    - GSK Investigational Site
  - Odesa, Ukraine, 65010
    - GSK Investigational Site
  - Odesa, Ukraine, 65114
    - GSK Investigational Site
  - Odessa, Ukraine, 65025
    - GSK Investigational Site
  - Odessa, Ukraine, 65009
    - GSK Investigational Site
  - Poltava, Ukraine, 36024
    - GSK Investigational Site
  - Poltava, Ukraine, 36028
    - GSK Investigational Site
  - Poltava, Ukraine, 36038
    - GSK Investigational Site
  - Simferopol, Ukraine, 95043
    - GSK Investigational Site
  - Sumy, Ukraine, 40022
    - GSK Investigational Site
  - Sumy, Ukraine, 40030
    - GSK Investigational Site
  - Sympheropol, Ukraine, 95017
    - GSK Investigational Site
  - Ternopil, Ukraine, 46002
    - GSK Investigational Site
  - Uzhhorod, Ukraine, 88000
    - GSK Investigational Site
  - Uzhhorod, Ukraine, 88009
    - GSK Investigational Site
  - Uzhhorod, Ukraine, 88017
    - GSK Investigational Site
  - Vinnytsia, Ukraine, 21018
    - GSK Investigational Site
  - Vinnytsia, Ukraine, 21029
    - GSK Investigational Site
  - Vinnytsya, Ukraine, 21001
    - GSK Investigational Site
  - Yalta, Ukraine, 98603
    - GSK Investigational Site
  - Zaporizhia, Ukraine, 69035
    - GSK Investigational Site
  - Zaporizhzhia, Ukraine, 69600
    - GSK Investigational Site
  - Zaporizhzhia, Ukraine, 69106
    - GSK Investigational Site
  - Zaporizhzhia, Ukraine, 69118
    - GSK Investigational Site
  - Zaporizhzhya, Ukraine, 69001
    - GSK Investigational Site
  - Zhytomyr, Ukraine, 10002
    - GSK Investigational Site
Ungarn
- - Balassagyarmat, Ungarn, 2660
    - GSK Investigational Site
  - Budapest, Ungarn, 1036
    - GSK Investigational Site
  - Budapest, Ungarn, 1122
    - GSK Investigational Site
  - Budapest, Ungarn, 1125
    - GSK Investigational Site
  - Budapest, Ungarn, 1134
    - GSK Investigational Site
  - Budapest, Ungarn, 1204
    - GSK Investigational Site
  - Budapest, Ungarn, 1101
    - GSK Investigational Site
  - Budapest, Ungarn, 1117
    - GSK Investigational Site
  - Budapest, Ungarn, 1191
    - GSK Investigational Site
  - Debrecen, Ungarn, 4031
    - GSK Investigational Site
  - Debrecen, Ungarn, 4026
    - GSK Investigational Site
  - Gyula, Ungarn, 5703
    - GSK Investigational Site
  - Kaposvár, Ungarn, 7400
    - GSK Investigational Site
  - Komarom, Ungarn, 2900
    - GSK Investigational Site
  - Komló, Ungarn, 7300
    - GSK Investigational Site
  - Mosonmagyaróvár, Ungarn, 9200
    - GSK Investigational Site
  - Nagykanizsa, Ungarn, 8800
    - GSK Investigational Site
  - Nyiregyhaza, Ungarn, 4400
    - GSK Investigational Site
  - Pécs, Ungarn, 7635
    - GSK Investigational Site
  - Sopron, Ungarn, 9400
    - GSK Investigational Site
  - Szigetszentmiklos, Ungarn, 2310
    - GSK Investigational Site
  - Szikszó, Ungarn, H-3800
    - GSK Investigational Site
  - Szombathely, Ungarn, 9700
    - GSK Investigational Site
  - Tatabanya, Ungarn, 2800
    - GSK Investigational Site
  - Vasarosnameny, Ungarn, 4800
    - GSK Investigational Site
  - Zalaegerszeg, Ungarn, 8900
    - GSK Investigational Site
Vietnam
- - Can Tho, Vietnam, 90000
    - GSK Investigational Site
  - Ha Noi, Vietnam, 10000
    - GSK Investigational Site
  - Ho Chi Minh, Vietnam, 70000
    - GSK Investigational Site
  - Hue, Vietnam, 53000
    - GSK Investigational Site
Østrig
- - Feldbach, Østrig, 8330
    - GSK Investigational Site
  - Feldkirch, Østrig, 6800
    - GSK Investigational Site
  - Grieskirchen, Østrig, A-4710
    - GSK Investigational Site
  - Innsbruck, Østrig, A-6020
    - GSK Investigational Site
  - Linz, Østrig, 4020
    - GSK Investigational Site
  - Salzburg, Østrig, A-5020
    - GSK Investigational Site
  - Salzburg, Østrig, 5020
    - GSK Investigational Site
  - Spittal/Drau, Østrig, 9800
    - GSK Investigational Site
  - Thalheim bei Wels, Østrig, 4600
    - GSK Investigational Site
  - Vienna, Østrig, A-1120
    - GSK Investigational Site
  - Wels, Østrig, 4600
    - GSK Investigational Site
  - Zwettl, Østrig, 3910
    - GSK Investigational Site

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

40 år til 80 år (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

Inklusionskriterier:

Emnetype: ambulant.
Informeret samtykke: Forsøgspersoner skal give deres underskrevne og daterede skriftlige informerede samtykke for at deltage.
Køn: Mand eller kvinde. Kvindelige forsøgspersoner skal være postmenopausale eller bruge en yderst effektiv metode til at undgå graviditet. Beslutningen om at inkludere eller udelukke kvinder i den fødedygtige alder kan træffes efter investigatorens skøn i overensstemmelse med lokal praksis i forhold til passende prævention.
Alder: >=40 og <=80 år ved screening (besøg 1).
Tobaksbrug: Forsøgspersoner med en aktuel eller tidligere historie med >=10 pakkeår med cigaretrygning ved screening (besøg 1). Tidligere rygere er defineret som dem, der er holdt op med at ryge i mindst 6 måneder før besøg 1.
Luftstrømsblokering:

Forsøgspersoner med et målt post-albuterol/salbutamol forceret ekspiratorisk volumen på 1 sekund (FEV1)/(forceret vital kapacitet) FVC-forhold på <=0,70 ved screening (besøg 1).

Forsøgspersoner med en målt post-albuterol/salbutamol FEV1 >=50 og <=70% af forudsagte normale værdier beregnet ved hjælp af NHANES III referenceligninger [Hankinson, 1999; Hankinson, 2010] ved Screening (besøg 1).

Post-bronkodilatator spirometri vil blive udført ca. 15 minutter efter, at forsøgspersonen selv har administreret 4 inhalationer (dvs. i alt 400 mcg) albuterol/salbutamol via en inhalator med afmålt dosis (MDI) med et ventilholdekammer. FEV1/FVC-forholdet og FEV1 procent forudsagte værdier vil blive beregnet.

Symptomer på KOL: Forsøgspersoner skal score 2 eller højere på den modificerede Medical Research Council Dyspnø-skala (besøg 1)
Kardiovaskulær sygdom:

For patienter >= 40 år: en af følgende:

Etableret (dvs. ved kliniske tegn eller billeddiagnostiske undersøgelser) koronararteriesygdom (CAD) Etableret (dvs. ved kliniske tegn eller billeddiagnostiske undersøgelser) perifer vaskulær sygdom (PVD) Tidligere slagtilfælde Tidligere hjerteinfarkt Diabetes mellitus med målorgansygdom ELLER

For patienter >=60 år: enhver 2 af følgende:

Bliver behandlet for hyperkolesterolæmi Bliver behandlet for hypertension Bliver behandlet for diabetes mellitus Bliver behandlet for perifer vaskulær sygdom

Ekskluderingskriterier:

Graviditet: Kvinder, der er gravide eller ammende.
Astma: Personer med en aktuel diagnose astma. (Forsøgspersoner med en tidligere astmahistorie er kvalificerede, hvis de også har en aktuel diagnose KOL).
alfa 1-antitrypsin mangel: Personer med kendt alfa-1 antitrypsin mangel som den underliggende årsag til KOL.
Andre luftvejslidelser: Personer med aktiv tuberkulose, lungekræft, bronkiektasi, sarkoidose, lungefibrose, pulmonal hypertension, interstitielle lungesygdomme eller andre aktive lungesygdomme.
Lungeresektion eller transplantation: Personer med lungevolumenreduktionskirurgi inden for de 12 måneder forud for screening eller har fået foretaget en lungetransplantation.
En moderat/svær KOL-eksacerbation, der ikke er forsvundet mindst 14 dage før besøg 1 og mindst 30 dage efter den sidste dosis orale kortikosteroider (hvis relevant).
Aktuelt alvorligt hjertesvigt (New York Heart Association klasse IV). Forsøgspersoner vil også blive udelukket, hvis de har en kendt udstødningsfraktion på <30 %, eller hvis de har en implanterbar cardioverter-defibrillator (ICD).
Andre sygdomme/abnormiteter: Enhver livstruende tilstand med forventet levetid <3 år, bortset fra vaskulær sygdom eller KOL, der kan forhindre forsøgspersonen i at gennemføre undersøgelsen.
Slutstadiet af kronisk nyresygdom: Patienter vil blive udelukket, hvis de er i nyresubstitutionsterapi (hæmodialyse eller peritoneal).
Lægemiddel-/fødevareallergi: Personer med en historie med overfølsomhed over for nogen af undersøgelsesmedicinerne (f. beta-agonister, kortikosteroid) eller komponenter i inhalationspulveret (f.eks. laktose, magnesiumstearat). Derudover vil patienter med en anamnese med svær mælkeproteinallergi, der efter undersøgelseslægens opfattelse kontraindikerer forsøgspersonens deltagelse, også blive udelukket.
Stof-/alkoholmisbrug: Personer med en kendt eller mistænkt historie med alkohol- eller stofmisbrug inden for de sidste 2 år.
Iltbehandling: Personer, der modtager behandling med langvarig oxygenbehandling (LTOT) eller natlig oxygenbehandling påkrævet i mere end 12 timer om dagen. Brug af ilt prn (dvs. <=12 timer om dagen) er ikke udelukkende.
Tvivlsom gyldighed af samtykke: Forsøgspersoner med en historie med psykiatrisk sygdom, intellektuel mangel, dårlig motivation eller andre forhold, der vil begrænse gyldigheden af informeret samtykke til at deltage i undersøgelsen eller den potentielle overholdelse af undersøgelsesprocedurer.
Tilknytning til efterforskers websted: Undersøgelsesundersøgere, underforskere, undersøgelseskoordinatorer, ansatte hos en deltagende efterforsker eller nærmeste familiemedlemmer til førnævnte er udelukket fra at deltage i denne undersøgelse.
Yderligere medicin: Brug af følgende medicin inden for følgende tidsintervaller før besøg 1 eller under undersøgelsen (medmindre andet er angivet):

Medicin Ingen brug inden for følgende tidsintervaller før screening eller derefter på noget tidspunkt under undersøgelsen (medmindre andet er angivet) Inhalerede Langtidsvirkende beta-agonister (LABA) 48 timer ICS/LABA kombinationsprodukter 48 timer Inhalerede kortikosteroider 48 timer Tiotropium 1 uge Systemisk , Orale, parenterale, intra-artikulære kortikosteroider 30 dage (orale og systemiske kortikosteroider kan bruges til at behandle KOL-eksacerbationer under undersøgelsen) Cytochrom P450 3A4 stærke hæmmere inklusive, men ikke begrænset til antiretrovirale midler (proteasehæmmere) (f.eks. Indinavir, Ritona, Nevir, Neviravir Saquinavir); Imidazol og Triazol anti-svampemidler (f.eks. Ketaconazol, Itraconazol); Clarithromycin, Telithromycin, Amiodarone og Nefazodon 6 uger Grapefrugt er tilladt op til besøg 1, derefter begrænset til højst ét glas grapefrugtjuice (250 ml/8 ounces) eller én grapefrugt om dagen Ethvert andet forsøgslægemiddel 30 dage eller 5 halvdelen liv, alt efter hvad der er længst.

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Behandling
Tildeling: Randomiseret
Interventionel model: Parallel tildeling
Maskning: Firedobbelt

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Eksperimentel: fluticasonfuroat/vilanterol Kombination af begge produkter i én inhalator	Medicin: fluticasonfuroat/vilanterol 100/25 mcg givet én gang dagligt via en ny tørpulverinhalator
Eksperimentel: fluticasonfuroat komparator af individuel komponent	Medicin: fluticasonfuroat 100 mcg givet én gang dagligt via en ny tørpulverinhalator
Eksperimentel: vilanterol komparator af individuel komponent	Medicin: vilanterol 25mcg givet én gang dagligt via en ny tørpulverinhalator
Placebo komparator: placebo en gang dagligt via inhalator	Andet: Placebo placebo komparator én gang dagligt via en ny tørpulverinhalator

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Antal deltagere med død (både til og fra behandling) på grund af enhver årsag, tid op til eller på den forudbestemte fælles slutdato Tidsramme: Fra randomiseringsdatoen til datoen for dødsfald på grund af en hvilken som helst årsag (gennemsnit af 2 undersøgelsesår)	Død af enhver årsag: som fandt sted fra dagen for start-IP indtil Commone End Date (CED). Common End Date (CED) er undersøgelsens slutdato, der var forudbestemt, hvor ca. 1000 dødsfald ville have fundet sted i Intent-toTreat Efficacy (ITT-E) populationen. Kun dødsfald, der fandt sted på eller før CED blev brugt til den primære analyse. De, der ikke var døde af CED, men som var kendt for at være i live på eller efter CED, blev censureret på CED. Cox Proportional Hazards (PH)-modellen blev justeret for alder og køn, inklusive alle 4 arme. Et hazard ratio på mindre end 1 indikerer en lavere dødsrate i forhold til placebo eller anden arm. ITT-E-populationen bestod af alle deltagere i sikkerhedspopulationen (dvs. randomiseret til IP og som modtog mindst én dosis IP), med undtagelse af dem, der blev rekrutteret på steder, der var lukkede.	Fra randomiseringsdatoen til datoen for dødsfald på grund af en hvilken som helst årsag (gennemsnit af 2 undersøgelsesår)

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Fald i forceret udåndingsvolumen på 1 sekund (FEV1) Tidsramme: Fra startdato for IP til IP stopdato + 1 (vurderet op til 4 år)	FEV1 er et mål for lungefunktionen og er defineret som den maksimale mængde luft, der kan udåndes kraftigt på et sekund. Effekten af behandling på faldet af post bronkodilatator FEV1 registreret i behandlingsperioden blev analyseret ved hjælp af en særlig form for en blandet effektmodel - en tilfældig koefficientmodel. FEV1 blev tilpasset som responsvariabel med behandlingsgruppe, alder, køn, baseline FEV1 og tid på behandling som faste effekter. Tid på behandling blev behandlet som en kontinuerlig variabel. Denne model tillod en indledende stigning i FEV1, men testede derefter forskellen i hældninger fra den første post-baseline-måling, som var på 3 måneder. En negativ hældning indikerer et fald. En positiv behandlingsforskel indikerer en langsommere hastighed af fald i forhold til placebo eller komponent. Kun deltagere med mindst én FEV1-måling under behandling efter bronkodilatator blev analyseret.	Fra startdato for IP til IP stopdato + 1 (vurderet op til 4 år)
Antal deltagere med første kardiovaskulære (CV) sammensatte hændelser under behandling, der er indtruffet på eller før fælles slutdato Tidsramme: Fra starten af IP til første behandlings CV hændelse indtil 7 dage efter den sidste dosis af IP (gennemsnit af 2 undersøgelsesår)	CV-sammensatte hændelse under behandling består af den første hændelse, der bedømmes som CV-død under behandling, myokardieinfarkt, slagtilfælde, ustabil angina eller forbigående iskæmisk anfald oplevet af en deltager. Hændelser, der opstod ikke mere end 7 dage efter deltagernes sidste dosis af IP, betragtes som bivirkninger under behandlingen. Almindelig slutdato er undersøgelsens slutdato, hvor cirka 1000 dødsfald ville have fundet sted i ITT-E-populationen. Cox PH-model blev brugt til at vurdere tid til den første CV-sammensatte hændelse under behandling. Cox PH-modellen blev justeret for alder, køn og indikatorer for iskæmisk og vaskulær sygdom, inklusive alle fire behandlingsarme. Et hazard ratio mindre end 1 indikerer en lavere risiko for en første CV-hændelse sammenlignet med placebo eller en hvilken som helst arm.	Fra starten af IP til første behandlings CV hændelse indtil 7 dage efter den sidste dosis af IP (gennemsnit af 2 undersøgelsesår)

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

GlaxoSmithKline

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Hjælpsomme links

Researchers can use this site to request access to anonymised patient level data and/or supporting documents from clinical studies to conduct further research.

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

25. januar 2011

Primær færdiggørelse (Faktiske)

15. juli 2015

Studieafslutning (Faktiske)

15. juli 2015

Datoer for studieregistrering

Først indsendt

3. februar 2011

Først indsendt, der opfyldte QC-kriterier

10. marts 2011

Først opslået (Skøn)

14. marts 2011

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

6. august 2018

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

2. august 2018

Sidst verificeret

1. august 2018

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

113782

Plan for individuelle deltagerdata (IPD)

Studiedata/dokumenter

Statistisk analyseplan
Informations-id: 113782

Oplysningskommentarer: For yderligere information om denne undersøgelse henvises til GSK Clinical Study Register
Klinisk undersøgelsesrapport
Informations-id: 113782

Oplysningskommentarer: For yderligere information om denne undersøgelse henvises til GSK Clinical Study Register
Individuelt deltagerdatasæt
Informations-id: 113782

Oplysningskommentarer: For yderligere information om denne undersøgelse henvises til GSK Clinical Study Register
Annoteret sagsbetænkningsformular
Informations-id: 113782

Oplysningskommentarer: For yderligere information om denne undersøgelse henvises til GSK Clinical Study Register
Formular til informeret samtykke
Informations-id: 113782

Oplysningskommentarer: For yderligere information om denne undersøgelse henvises til GSK Clinical Study Register
Datasætspecifikation
Informations-id: 113782

Oplysningskommentarer: For yderligere information om denne undersøgelse henvises til GSK Clinical Study Register
Studieprotokol
Informations-id: 113782

Oplysningskommentarer: For yderligere information om denne undersøgelse henvises til GSK Clinical Study Register

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med fluticasonfuroat/vilanterol

GlaxoSmithKline

Afsluttet

En undersøgelse af effektivitet og sikkerhed af fluticasonfuroat/vilanterol (FF/VI) 200/25 mikrogram (mcg), FF/VI 100/25 mcg og FF 100 mcg hos voksne og unge med vedvarende astma.

Astma

Forenede Stater, Argentina, Tyskland, Rumænien, Den Russiske Føderation, Ukraine, Chile, Sverige, Mexico, Holland, Polen
Brigham and Women's Hospital

Afsluttet

Replikering af IMPACT COPD-forsøget i data om sundhedsanprisninger

KOL

Forenede Stater
Sandoz

Trukket tilbage

Studie til evaluering af terapeutisk ækvivalens og sikkerhed for Fluticasone Furoate og Vilanterol Inhalationspulver 100 mcg/25 mcg og BREO ELLIPTA 100 mcg/25 mcg hos deltagere med astma

Åndedræt

Forenede Stater
GlaxoSmithKline

Afsluttet

En undersøgelse til at sammenligne effektiviteten og sikkerheden af fluticasonfuroat (FF) 100 mcg én gang dagligt med fluticasonpropionat (FP) 250 mcg to gange dagligt (BD) og FP 100 mcg BD hos velkontrollerede astmatiske japanske forsøgspersoner

Astma

Japan
GlaxoSmithKline

Afsluttet

Undersøgelse, der evaluerer effektiviteten og sikkerheden af fluticasonfuroat/vilanterol inhalationspulver (FF/VI) sammenlignet med vilanterol inhalationspulver (VI) hos forsøgspersoner med kronisk obstruktiv lungesygdom (KOL)

Lungesygdom, kronisk obstruktiv

Forenede Stater, Tyskland, Japan, Polen, Rumænien, Den Russiske Føderation, Ukraine, Taiwan, Bulgarien, Sydafrika, Korea, Republikken
GlaxoSmithKline

Afsluttet

Undersøgelse, der evaluerer effekten af fluticasonfuroat/vilanterol (FF/VI) inhalationspulver sammenlignet med vilanterol (VI) inhalationspulver på knoglemineraltæthed (BMD) hos personer med kronisk obstruktiv lungesygdom (KOL).

Lungesygdom, kronisk obstruktiv

Forenede Stater, Tyskland, Spanien, Holland, Canada
GlaxoSmithKline

Afsluttet

En 24-ugers arteriel stivhedsundersøgelse med fluticasonfuroat/vilanterol i KOL

Lungesygdom, kronisk obstruktiv

Forenede Stater, Tyskland, Filippinerne, Thailand, Korea, Republikken, Norge
National Institute of Respiratory Diseases, Mexico

Afsluttet

Effekt og sikkerhed af ICS/LABA vs. LAMA/LABA hos patienter med forskellige KOL-fænotyper.

KOL

Mexico
GlaxoSmithKline

Afsluttet

Bioækvivalensundersøgelse til sammenligning af Fluticasone Furoat (FF) 1-stavs inhalator med FF 2-stavs inhalator og med FF/Vilanterol kombination

Astma

Tyskland
GlaxoSmithKline

Afsluttet

Undersøgelse HZA106829: Effekt/sikkerhedsundersøgelse af fluticasonfuroat/vilanterol (GW642444) hos voksne og unge astmatikere

Astma

Forenede Stater, Tyskland, Japan, Rumænien, Den Russiske Føderation, Polen

Undersøgelse for at evaluere effekten af ​​fluticasonfuroat/vilanterol på overlevelse hos personer med kronisk obstruktiv lungesygdom

Studieoversigt

Status

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsestype

Tilmelding (Faktiske)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Køn, der er berettiget til at studere

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Publikationer og nyttige links

Generelle publikationer

Hjælpsomme links

Datoer for undersøgelser

Studer store datoer

Studiestart (Faktiske)

Primær færdiggørelse (Faktiske)

Studieafslutning (Faktiske)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Skøn)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Plan for individuelle deltagerdata (IPD)

Studiedata/dokumenter

Kliniske forsøg med fluticasonfuroat/vilanterol

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Montenegro

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer

Undersøgelse for at evaluere effekten af fluticasonfuroat/vilanterol på overlevelse hos personer med kronisk obstruktiv lungesygdom