Study to Evaluate the Effect of Fluticasone Furoate/Vilanterol on Survival in Subjects With Chronic Obstructive Pulmonary Disease
August 2, 2018 updated by: GlaxoSmithKline
A Clinical Outcomes Study to Compare the Effect of Fluticasone Furoate/Vilanterol Inhalation Powder 100/25mcg With Placebo on Survival in Subjects With Moderate Chronic Obstructive Pulmonary Disease (COPD) and a History of or at Increased Risk for Cardiovascular Disease
The purpose of this study is to determine if fluticasone furoate/vilanterol improves survival in patients with chronic obstructive pulmonary disease with a history of or increased risk of heart disease.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
Despite a potential link between the pathogenetic mechanisms involved in Chronic Obstructive Pulmonary Disease (COPD) and atherosclerotic cardiovascular disease, there are no currently approved therapies for patients with COPD that have clearly shown an additional beneficial effect in patients with cardiovascular comorbidities. The TOwards a Revolution in COPD Health (TORCH) study assessed the impact of the inhaled corticosteroid (ICS) fluticasone propionate (FP) in combination with the long-acting beta agonist (LABA), salmeterol (SAL), in reducing all-cause mortality. TORCH demonstrated a 17.5% reduction on all-cause mortality with salmeterol-fluticasone propionate combination (SFC) compared with placebo (HR=0.825, 95% CI (0.681, 1.002), p=0.052) in the entire COPD population with disease severity form moderate to very severe. A post hoc analysis of the data restricted to those subjects with an forced expiratory volume in 1 second (FEV1) >=50% predicted with an apparent history of cardiovascular co-morbidities (defined as use at baseline of beta-blockers, angiotensin converting enzyme inhibitors (ACEI)/angiotensin receptor blockers (ARB), HMG CoA reductase inhibitors (i.e. statins) or a prior MI recorded at baseline) demonstrated a 49% reduction in the risk of dying within 96 weeks for the comparison of SFC with placebo. These post hoc data suggest the possibility of an ICS/LABA combination product to be of substantial benefit in COPD subjects with less severe airflow obstruction yet with increased cardiovascular risk.
The mechanism by which SFC appears to be associated with a greater reduction in mortality in these less severe COPD subjects with concomitant cardiovascular comorbidities is speculative at present, but could potentially in part be related to a lessening of the degree of inflammation in the systemic circulation, potential plaque stabilization and/or amelioration of arterial stiffness.
ICS/LABA combinations that are currently available require twice daily administration. A once daily ICS/LABA combination has the potential to improve patient compliance and as a result, overall disease management.
The purpose of this study is to prospectively evaluate the effect of the once daily ICS/LABA combination Fluticasone Furoate (FF)/Vilanterol (VI) on survival in subjects with moderate COPD (>=50 and =<70 % predicted FEV1 ) and a history of, or at increased risk for cardiovascular disease.
Study Type
Interventional
Enrollment (Actual)
16568
Phase
- Phase 3
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Buenos Aires, Argentina, C1120AAC
- GSK Investigational Site
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Buenos Aires, Argentina, C1425FVH
- GSK Investigational Site
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Buenos Aires, Argentina, C1280AEB
- GSK Investigational Site
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Buenos Aires, Argentina, B1704ETD
- GSK Investigational Site
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Buenos Aires, Argentina, C1061ABD
- GSK Investigational Site
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Buenos Aires, Argentina, C1407HUF
- GSK Investigational Site
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Buenos Aires, Argentina, C1425AGC
- GSK Investigational Site
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Buenos Aires, Argentina, C1437BZ
- GSK Investigational Site
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Ciudad Autonoma de Buenos Aires, Argentina, C1425BEN
- GSK Investigational Site
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Ciudad Autónoma de Buenos Aires, Argentina, C1426ABP
- GSK Investigational Site
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Cordoba, Argentina, 5000
- GSK Investigational Site
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Cordoba, Argentina, 5016
- GSK Investigational Site
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Cordoba, Argentina, 5900
- GSK Investigational Site
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Cordoba, Argentina, X5003DCE
- GSK Investigational Site
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Cordoba, Argentina, X5004BAL
- GSK Investigational Site
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Cordoba, Argentina, X5006
- GSK Investigational Site
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Coronel Suarez, Argentina, 7540
- GSK Investigational Site
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Corrientes, Argentina, W3400AVK
- GSK Investigational Site
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Florencio Varela, Argentina, C1073ABA
- GSK Investigational Site
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Formosa, Argentina, 3600
- GSK Investigational Site
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Jujuy, Argentina, 4600
- GSK Investigational Site
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Lanús, Argentina, B1824KAJ
- GSK Investigational Site
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Mar del Plata, Argentina, B7600FYK
- GSK Investigational Site
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Mendoza, Argentina, M5500CCG
- GSK Investigational Site
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Mendoza, Argentina, 5500
- GSK Investigational Site
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Mendoza, Argentina, MM5500
- GSK Investigational Site
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Monte Grande, Argentina, 1842
- GSK Investigational Site
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Rosario, Argentina, 2000
- GSK Investigational Site
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Rosario, Argentina, S2000CXP
- GSK Investigational Site
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Salta, Argentina, A4400ERH
- GSK Investigational Site
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Salta, Argentina, A4400ANG
- GSK Investigational Site
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San Luis, Argentina, 5700
- GSK Investigational Site
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San Miguel de Tucuman, Argentina, 4000
- GSK Investigational Site
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San Miguel de Tucumán, Argentina, 4000
- GSK Investigational Site
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Santa Fe, Argentina, 3000
- GSK Investigational Site
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Santa Fe, Argentina, 3016
- GSK Investigational Site
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Santiago del Estero, Argentina
- GSK Investigational Site
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Buenos Aires
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Adrogue, Buenos Aires, Argentina, B1846DSK
- GSK Investigational Site
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Bahia Blanca, Buenos Aires, Argentina, B8000FTD
- GSK Investigational Site
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Ciudad Autnónoma de Buenos Aires, Buenos Aires, Argentina, C1186ACB
- GSK Investigational Site
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Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1028AAP
- GSK Investigational Site
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Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1122AAK
- GSK Investigational Site
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Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1405BCH
- GSK Investigational Site
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Derqui, Pilar, Buenos Aires, Argentina, B1629AHJ
- GSK Investigational Site
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Florencio Varela, Buenos Aires, Argentina, 1888
- GSK Investigational Site
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La Plata, Buenos Aires, Argentina, B1900AXI
- GSK Investigational Site
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La Plata, Buenos Aires, Argentina, 1900
- GSK Investigational Site
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Mar del Plata, Buenos Aires, Argentina, B7600FZN
- GSK Investigational Site
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Nueve de Julio, Buenos Aires, Argentina, B6500BWQ
- GSK Investigational Site
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Olivos, Buenos Aires, Argentina, B1605DSX
- GSK Investigational Site
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Pergamino, Buenos Aires, Argentina, B2700CPM
- GSK Investigational Site
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Quilmes, Buenos Aires, Argentina, B1878FNR
- GSK Investigational Site
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Quilmes, Buenos Aires, Argentina, 1878
- GSK Investigational Site
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San Isidro, Buenos Aires, Argentina, B1642DCD
- GSK Investigational Site
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San Martin, Buenos Aires, Argentina, 1650
- GSK Investigational Site
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San Nicolas, Buenos Aires, Argentina, B2900DMH
- GSK Investigational Site
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San Nicolas, Buenos Aires, Argentina, B2900IIC
- GSK Investigational Site
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Vicente López, Buenos Aires, Argentina, 1602
- GSK Investigational Site
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Córdova
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Cordoba, Córdova, Argentina, X5000AAW
- GSK Investigational Site
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Cordoba, Córdova, Argentina, X5003DCE
- GSK Investigational Site
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Entre Ríos
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Concepcion del Uruguay, Entre Ríos, Argentina, 3260
- GSK Investigational Site
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Parana, Entre Ríos, Argentina, E3100BHK
- GSK Investigational Site
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Mendoza
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Godoy Cruz, Mendoza, Argentina, 5501
- GSK Investigational Site
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Río Negro
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Cipoletti, Rio Negro, Río Negro, Argentina, R8324CVE
- GSK Investigational Site
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Santa Fe
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Rosario, Santa Fe, Argentina, 2000
- GSK Investigational Site
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Rosario, Santa Fe, Argentina, S2000BIF
- GSK Investigational Site
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Rosario, Santa Fe, Argentina, S2000CVD
- GSK Investigational Site
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Rosario, Santa Fe, Argentina, S2002OJN
- GSK Investigational Site
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Rosario, Santa Fe, Argentina, S2005PAF
- GSK Investigational Site
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Tucumán
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Tucuman, Tucumán, Argentina, 4000
- GSK Investigational Site
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Glen Osmond, Australia, 5064
- GSK Investigational Site
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Queensland
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Cairns, Queensland, Australia, 4870
- GSK Investigational Site
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Redcliffe, Queensland, Australia, 4020
- GSK Investigational Site
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South Australia
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Bedford Park, South Australia, Australia, 5042
- GSK Investigational Site
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Daw Park, South Australia, Australia, 5041
- GSK Investigational Site
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Victoria
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Footscray, Victoria, Australia, 3011
- GSK Investigational Site
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Geelong, Victoria, Australia, 3220
- GSK Investigational Site
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Melbourne, Victoria, Australia, 3004
- GSK Investigational Site
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Feldbach, Austria, 8330
- GSK Investigational Site
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Feldkirch, Austria, 6800
- GSK Investigational Site
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Grieskirchen, Austria, A-4710
- GSK Investigational Site
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Innsbruck, Austria, A-6020
- GSK Investigational Site
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Linz, Austria, 4020
- GSK Investigational Site
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Salzburg, Austria, A-5020
- GSK Investigational Site
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Salzburg, Austria, 5020
- GSK Investigational Site
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Spittal/Drau, Austria, 9800
- GSK Investigational Site
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Thalheim bei Wels, Austria, 4600
- GSK Investigational Site
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Vienna, Austria, A-1120
- GSK Investigational Site
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Wels, Austria, 4600
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Zwettl, Austria, 3910
- GSK Investigational Site
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Brest, Belarus, 224027
- GSK Investigational Site
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Gomel, Belarus, 246040
- GSK Investigational Site
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Grodno, Belarus, 230017
- GSK Investigational Site
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Minsk, Belarus, 220030
- GSK Investigational Site
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Minsk, Belarus, 220053
- GSK Investigational Site
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Minsk, Belarus, 223041
- GSK Investigational Site
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Vitebsk, Belarus, 210037
- GSK Investigational Site
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Diest, Belgium, 3290
- GSK Investigational Site
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Erpent, Belgium, 5101
- GSK Investigational Site
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Gilly, Belgium, 6060
- GSK Investigational Site
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Mons, Belgium, 7000
- GSK Investigational Site
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Namur, Belgium, 5000
- GSK Investigational Site
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Banja Luka, Bosnia and Herzegovina, 78000
- GSK Investigational Site
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Banjaluka, Bosnia and Herzegovina, 78000
- GSK Investigational Site
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Bihac, Bosnia and Herzegovina, 77 000
- GSK Investigational Site
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Bihac, Bosnia and Herzegovina, 77000
- GSK Investigational Site
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Bijeljina, Bosnia and Herzegovina, 76300
- GSK Investigational Site
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Brcko, Bosnia and Herzegovina, 76000
- GSK Investigational Site
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Foca, Bosnia and Herzegovina, 73300
- GSK Investigational Site
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Gracanica, Bosnia and Herzegovina, 75320
- GSK Investigational Site
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Gradiska, Bosnia and Herzegovina, 78400
- GSK Investigational Site
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Istocno Sarajevo, Bosnia and Herzegovina, 71123
- GSK Investigational Site
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Konjic, Bosnia and Herzegovina, 88400
- GSK Investigational Site
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Mostar, Bosnia and Herzegovina, 88000
- GSK Investigational Site
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Novi Travnik, Bosnia and Herzegovina
- GSK Investigational Site
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Pale, Bosnia and Herzegovina, 71420
- GSK Investigational Site
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Sarajevo, Bosnia and Herzegovina, 71000
- GSK Investigational Site
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Sarajevo, Bosnia and Herzegovina, 71320
- GSK Investigational Site
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Srebrenik, Bosnia and Herzegovina, 75350
- GSK Investigational Site
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Tesanj, Bosnia and Herzegovina, 74260
- GSK Investigational Site
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Teslić, Bosnia and Herzegovina, 74270
- GSK Investigational Site
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Travnik, Bosnia and Herzegovina, 72270
- GSK Investigational Site
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Trebinje, Bosnia and Herzegovina, 89101
- GSK Investigational Site
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Tuzla, Bosnia and Herzegovina, 75000
- GSK Investigational Site
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Visegrad, Bosnia and Herzegovina, 73240
- GSK Investigational Site
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Zenica, Bosnia and Herzegovina, 72000
- GSK Investigational Site
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Blagoevgrad, Bulgaria, 2700
- GSK Investigational Site
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Dimitrovgrad, Bulgaria, 6400
- GSK Investigational Site
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Gabrovo, Bulgaria, 5300
- GSK Investigational Site
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Kozlodui, Bulgaria, 3320
- GSK Investigational Site
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Lovech, Bulgaria, 5500
- GSK Investigational Site
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Pazardjik, Bulgaria, 4400
- GSK Investigational Site
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Petrich, Bulgaria, 2850
- GSK Investigational Site
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Pleven, Bulgaria, 5800
- GSK Investigational Site
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Plovdiv, Bulgaria, 4002
- GSK Investigational Site
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Razgrad, Bulgaria, 7200
- GSK Investigational Site
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Rousse, Bulgaria, 7000
- GSK Investigational Site
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Sevlievo, Bulgaria, 5400
- GSK Investigational Site
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Sliven, Bulgaria, 8800
- GSK Investigational Site
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Sofia, Bulgaria, 1431
- GSK Investigational Site
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Sofia, Bulgaria, 1606
- GSK Investigational Site
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Sofia, Bulgaria, 1233
- GSK Investigational Site
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Sofia, Bulgaria, 1000
- GSK Investigational Site
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Sofia, Bulgaria, 1202
- GSK Investigational Site
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Sofia, Bulgaria, 1784
- GSK Investigational Site
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Sofia, Bulgaria, 1336
- GSK Investigational Site
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Sofia, Bulgaria, 1505
- GSK Investigational Site
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Sofia, Bulgaria, 1142
- GSK Investigational Site
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Sofia, Bulgaria, 1618
- GSK Investigational Site
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Stara Zagora, Bulgaria, 6000
- GSK Investigational Site
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Stara Zagora, Bulgaria, 6003
- GSK Investigational Site
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Troyan, Bulgaria, 5600
- GSK Investigational Site
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Varna, Bulgaria, 9000
- GSK Investigational Site
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Veliko Tarnovo, Bulgaria, 5000
- GSK Investigational Site
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Vidin, Bulgaria, 3700
- GSK Investigational Site
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Quebec, Canada, G1G 4A2
- GSK Investigational Site
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Alberta
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Edmonton, Alberta, Canada, T5A 4L8
- GSK Investigational Site
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Edmonton, Alberta, Canada, T5J 3S9
- GSK Investigational Site
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British Columbia
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Kamloops, British Columbia, Canada, V2C 1K7
- GSK Investigational Site
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Penticton, British Columbia, Canada, V2A 5C8
- GSK Investigational Site
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Vancouver, British Columbia, Canada, V5Z 4E1
- GSK Investigational Site
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West Vancouver, British Columbia, Canada, V7T 2Z3
- GSK Investigational Site
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Manitoba
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Winnipeg, Manitoba, Canada, R3H 2A6
- GSK Investigational Site
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Ontario
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Bolton, Ontario, Canada, L7E 4C8
- GSK Investigational Site
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Burlington, Ontario, Canada, L7N 3V2
- GSK Investigational Site
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Grimsby, Ontario, Canada, L3M 1P3
- GSK Investigational Site
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London, Ontario, Canada, N5Y 5K7
- GSK Investigational Site
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Mississauga, Ontario, Canada, L5M 2V8
- GSK Investigational Site
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Mississauga, Ontario, Canada, L4T 4J2
- GSK Investigational Site
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Newmarket, Ontario, Canada, L3Y 5G8
- GSK Investigational Site
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Orleans, Ontario, Canada, K4A 5E6
- GSK Investigational Site
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Sarnia, Ontario, Canada, N7T 4X3
- GSK Investigational Site
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Toronto, Ontario, Canada, M5T 3A9
- GSK Investigational Site
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Windsor, Ontario, Canada, N8X 5A6
- GSK Investigational Site
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Quebec
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Mirabel, Quebec, Canada, J7J 2K8
- GSK Investigational Site
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Montreal, Quebec, Canada, H2W1T8
- GSK Investigational Site
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Sainte Jerome, Quebec, Canada, J7Z 5T3
- GSK Investigational Site
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Región De La Araucania
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Temuco, Región De La Araucania, Chile
- GSK Investigational Site
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Temuco, Región De La Araucania, Chile, 4800798
- GSK Investigational Site
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Región Metro De Santiago
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Santiago, Región Metro De Santiago, Chile
- GSK Investigational Site
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Santiago, Región Metro De Santiago, Chile, 7500691
- GSK Investigational Site
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Santiago, Región Metro De Santiago, Chile, 8910131
- GSK Investigational Site
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Valparaíso
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Viña del Mar, Valparaíso, Chile, 2340000
- GSK Investigational Site
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Baotou, China
- GSK Investigational Site
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Beijing, China, 100029
- GSK Investigational Site
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Beijing, China, 100050
- GSK Investigational Site
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Beijing, China, 100020
- GSK Investigational Site
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Beijing, China, 100144
- GSK Investigational Site
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Beijing, China, 100070
- GSK Investigational Site
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Bengbu, China, 233000
- GSK Investigational Site
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Changchun, China, 130012
- GSK Investigational Site
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Chengdu, China, 610041
- GSK Investigational Site
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Chongqing, China, 400038
- GSK Investigational Site
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Chongqing, China, 400016
- GSK Investigational Site
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Chongqing, China, 400042
- GSK Investigational Site
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Fu Zhou, China
- GSK Investigational Site
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Fuzhou, China, 350025
- GSK Investigational Site
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Guangxi, China, 530021
- GSK Investigational Site
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Guangzhou, China, 510080
- GSK Investigational Site
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Hangzhou, China, 310014
- GSK Investigational Site
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Hefei, China, 230001
- GSK Investigational Site
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Huai'an, China, 223300
- GSK Investigational Site
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Jiangyin, China
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Luzhou, China
- GSK Investigational Site
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Nanchang, China, 330006
- GSK Investigational Site
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Nanjing, China, 210009
- GSK Investigational Site
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ShangHai, China, 200062
- GSK Investigational Site
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Shanghai, China, 200025
- GSK Investigational Site
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Shanghai, China, 200040
- GSK Investigational Site
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Shanghai, China, 200433
- GSK Investigational Site
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Shanghai, China, 200032
- GSK Investigational Site
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Shanghai, China, 200003
- GSK Investigational Site
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Shanghai, China, 200072
- GSK Investigational Site
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Tianjin, China, 300121
- GSK Investigational Site
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Wuxi, China, 214023
- GSK Investigational Site
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Guangdong
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Guangzhou, Guangdong, China, 510080
- GSK Investigational Site
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Guangzhou, Guangdong, China, 510515
- GSK Investigational Site
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Guangzhou, Guangdong, China, 510120
- GSK Investigational Site
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Shenzhen, Guangdong, China, 518020
- GSK Investigational Site
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Zhanjiang, Guangdong, China, 524001
- GSK Investigational Site
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Guangxi
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Nanning, Guangxi, China, 530021
- GSK Investigational Site
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Hainan
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Haikou, Hainan, China, 570311
- GSK Investigational Site
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Haikou, Hainan, China, 570001
- GSK Investigational Site
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Hohhot, Hainan, China, 010050
- GSK Investigational Site
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Hebei
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Shijiazhuang, Hebei, China, 050000
- GSK Investigational Site
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Hubei
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Wuhan, Hubei, China, 430060
- GSK Investigational Site
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Inner Mongolia
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Baotou, Inner Mongolia, China, 014010
- GSK Investigational Site
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Liaoning
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Shenyang, Liaoning, China, 110004
- GSK Investigational Site
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Ningxia
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Yinchuan, Ningxia, China, 750004
- GSK Investigational Site
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Shaanxi
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Xian, Shaanxi, China, 710032
- GSK Investigational Site
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Shandong
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Jinan, Shandong, China, 250033
- GSK Investigational Site
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Shanxi
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Taiyuan, Shanxi, China, 030001
- GSK Investigational Site
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Sichuan
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Chengdu, Sichuan, China, 610083
- GSK Investigational Site
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Barranquilla, Colombia
- GSK Investigational Site
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Bogota, Colombia
- GSK Investigational Site
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Bogota, Colombia, 111211
- GSK Investigational Site
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Bogotá, Colombia
- GSK Investigational Site
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Bogotá, Colombia, 80CO
- GSK Investigational Site
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Cali, Colombia, 571
- GSK Investigational Site
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Medellin, Colombia
- GSK Investigational Site
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Medellin, Colombia, 80372
- GSK Investigational Site
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Zipaquira, Colombia
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Cakovec, Croatia, 40000
- GSK Investigational Site
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Draganic, Croatia, 47201
- GSK Investigational Site
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Hrasce Turopoljsko, Croatia, 10020
- GSK Investigational Site
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Hreljin, Croatia, 51226
- GSK Investigational Site
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Ivankovo, Croatia, 32281
- GSK Investigational Site
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Karlovac, Croatia, 47000
- GSK Investigational Site
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Klenovnik, Croatia, 42244
- GSK Investigational Site
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Krapina, Croatia, 49000
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Kutina, Croatia, 44320
- GSK Investigational Site
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Novi Marof, Croatia, 42220
- GSK Investigational Site
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Osijek, Croatia, 31000
- GSK Investigational Site
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Retkovci, Croatia, 32282
- GSK Investigational Site
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Rijeka, Croatia, 51000
- GSK Investigational Site
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Samobor, Croatia, 10430
- GSK Investigational Site
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Senj, Croatia, 53270
- GSK Investigational Site
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Sibenik, Croatia, 22000
- GSK Investigational Site
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Sisak, Croatia, 44000
- GSK Investigational Site
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Split, Croatia, 21000
- GSK Investigational Site
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Strmec Samoborski, Croatia, 10434
- GSK Investigational Site
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Stubicke toplice, Croatia, 49244
- GSK Investigational Site
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Sukosan, Croatia, 23206
- GSK Investigational Site
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Varazdin, Croatia, 42000
- GSK Investigational Site
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Zabok, Croatia, 49210
- GSK Investigational Site
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Zadar, Croatia, 23000
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Zagreb, Croatia, 10000
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Benesov, Czechia, 256 01
- GSK Investigational Site
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Beroun, Czechia, 266 01
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Brno, Czechia, 612 00
- GSK Investigational Site
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Havlickuv brod, Czechia, 580 01
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Hlucin, Czechia, 748 01
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Holesov, Czechia, 769 01
- GSK Investigational Site
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Jaromer, Czechia, 551 01
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Jindrichuv Hradec, Czechia, 377 01
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Kolin, Czechia, 280 00
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Kralupy nad Vltavou, Czechia, 278 01
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Kromeriz, Czechia, 767 01
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Liberec, Czechia, 460 01
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Melnik, Czechia, 276 01
- GSK Investigational Site
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Moravsky Krumlov, Czechia, 672 01
- GSK Investigational Site
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Neratovice, Czechia, 277 11
- GSK Investigational Site
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Novy Jicin, Czechia, 741 01
- GSK Investigational Site
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Ostrava, Czechia, 72880
- GSK Investigational Site
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Ostrava - Belsky les, Czechia, 700 30
- GSK Investigational Site
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Ostrava - Poruba, Czechia, 70868
- GSK Investigational Site
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Plzen, Czechia, 301 00
- GSK Investigational Site
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Plzen, Czechia, 323 00
- GSK Investigational Site
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Praha 1, Czechia, 110 00
- GSK Investigational Site
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Praha 13, Czechia, 158 00
- GSK Investigational Site
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Praha 17, Czechia, 163 00
- GSK Investigational Site
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Praha 3, Czechia, 130 00
- GSK Investigational Site
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Praha 4, Czechia, 140 46
- GSK Investigational Site
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Praha 4, Czechia, 140 00
- GSK Investigational Site
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Praha 5, Czechia, 150 00
- GSK Investigational Site
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Praha 6, Czechia, 169 00
- GSK Investigational Site
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Rokycany, Czechia, 337 01
- GSK Investigational Site
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Rudna, Czechia, 252 19
- GSK Investigational Site
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Strakonice, Czechia, 386 01
- GSK Investigational Site
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Strakonice, Czechia, 386 29
- GSK Investigational Site
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Svitavy, Czechia, 568 25
- GSK Investigational Site
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Tremosna, Czechia, 330 11
- GSK Investigational Site
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Usti Nad Labem - Klise, Czechia, 400 01
- GSK Investigational Site
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Zatec, Czechia, 438 01
- GSK Investigational Site
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Ferolles Attilly, France, 77150
- GSK Investigational Site
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Paris Cedex 04, France, 75181
- GSK Investigational Site
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Strasbourg Cedex, France, 67091
- GSK Investigational Site
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Tarbes, France, 65013
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Toulouse cedex 9, France, 31059
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Batumi, Georgia, 6000
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Gurjaani, Georgia, 1500
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Kutaisi, Georgia, 1600
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Kvemo Kartli, Georgia, 3000
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Tbilisi, Georgia, 0101
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Tbilisi, Georgia, 0102
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Tbilisi, Georgia, 0114
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Tbilisi, Georgia, 0141
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Tbilisi, Georgia, 0144
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Tbilisi, Georgia, 0159
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Tbilisi, Georgia, 0160
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Tbilisi, Georgia, 0177
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Tbilisi, Georgia, 0186
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Tbilisi, Georgia, 0191
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Tbilisi, Georgia
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Berlin, Germany, 13086
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Berlin, Germany, 10717
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Berlin, Germany, 13125
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Berlin, Germany, 10787
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Berlin, Germany, 10789
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Berlin, Germany, 12627
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Berlin, Germany, 10969
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Berlin, Germany, 12203
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Berlin, Germany, 13507
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Berlin, Germany, 13156
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Berlin, Germany, 12687
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Berlin, Germany, 12043
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Berlin, Germany, 12099
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Berlin, Germany, 12165
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Hamburg, Germany, 22291
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Hamburg, Germany, 22763
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München, Germany, 81677
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Baden-Wuerttemberg
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Bruchsal, Baden-Wuerttemberg, Germany, 76646
- GSK Investigational Site
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Deggingen, Baden-Wuerttemberg, Germany, 73326
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Ettlingen, Baden-Wuerttemberg, Germany, 76275
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Frankfurt, Baden-Wuerttemberg, Germany, 60596
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Karlsruhe, Baden-Wuerttemberg, Germany, 76227
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Bayern
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Aschaffenburg, Bayern, Germany, 63739
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Augsburg, Bayern, Germany, 86150
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Augsburg, Bayern, Germany, 86156
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Bad Woerrishofen, Bayern, Germany, 86825
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Feldkirchen, Bayern, Germany, 83620
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Fuerth, Bayern, Germany, 90762
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Gauting, Bayern, Germany, 82131
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Hoechstadt, Bayern, Germany, 91315
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Landsberg, Bayern, Germany, 86899
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Muenchen, Bayern, Germany, 80335
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Vilshofen, Bayern, Germany, 94474
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Weissenhorn, Bayern, Germany, 89264
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Brandenburg
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Cottbus, Brandenburg, Germany, 03050
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Potsdam, Brandenburg, Germany, 14478
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Ruedersdorf, Brandenburg, Germany, 15562
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Hessen
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Bensheim, Hessen, Germany, 64625
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Darmstadt, Hessen, Germany, 64287
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Kassel, Hessen, Germany, 34121
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Marburg, Hessen, Germany, 35037
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Niedersachsen
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Goettingen, Niedersachsen, Germany, 37081
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Hannover, Niedersachsen, Germany, 30159
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Papenburg, Niedersachsen, Germany, 26871
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Stuhr, Niedersachsen, Germany, 28816
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Wardenburg, Niedersachsen, Germany, 26203
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Nordrhein-Westfalen
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Bergisch Gladbach, Nordrhein-Westfalen, Germany, 51429
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Bochum, Nordrhein-Westfalen, Germany, 44787
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Bonn, Nordrhein-Westfalen, Germany, 53119
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Bonn, Nordrhein-Westfalen, Germany, 53123
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Dortmund, Nordrhein-Westfalen, Germany, 44263
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Dueren, Nordrhein-Westfalen, Germany, 52349
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Essen, Nordrhein-Westfalen, Germany, 45355
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Essen, Nordrhein-Westfalen, Germany, 45136
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Gelsenkirchen, Nordrhein-Westfalen, Germany, 45879
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Hagen, Nordrhein-Westfalen, Germany, 58089
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Hagen, Nordrhein-Westfalen, Germany, 58095
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Harsewinkel, Nordrhein-Westfalen, Germany, 33428
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Koeln, Nordrhein-Westfalen, Germany, 51069
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Neuss, Nordrhein-Westfalen, Germany, 41462
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Solingen, Nordrhein-Westfalen, Germany, 42651
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Rheinland-Pfalz
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Foehren, Rheinland-Pfalz, Germany, 54343
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Ingelheim, Rheinland-Pfalz, Germany, 55218
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Mainz, Rheinland-Pfalz, Germany, 55116
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Neuwied, Rheinland-Pfalz, Germany, 56564
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Rhaunen, Rheinland-Pfalz, Germany, 55624
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Sachsen
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Dresden, Sachsen, Germany, 01307
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Dresden, Sachsen, Germany, 01067
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Goerlitz, Sachsen, Germany, 02826
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Leipzg, Sachsen, Germany, 04109
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Leipzig, Sachsen, Germany, 04275
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Leipzig, Sachsen, Germany, 04357
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Leipzig, Sachsen, Germany, 04103
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Leipzig, Sachsen, Germany, 04157
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Riesa, Sachsen, Germany, 01587
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Sachsen-Anhalt
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Magdeburg, Sachsen-Anhalt, Germany, 39104
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Zerbst, Sachsen-Anhalt, Germany, 39261
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Schleswig-Holstein
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Reinfeld, Schleswig-Holstein, Germany, 23858
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Schleswig, Schleswig-Holstein, Germany, 24837
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Thueringen
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Jena, Thueringen, Germany, 07740
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Athens, Greece, 11527
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Athens, Greece, 15126
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Thessaloniki, Greece, 57010
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Balassagyarmat, Hungary, 2660
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Budapest, Hungary, 1036
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Budapest, Hungary, 1122
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Budapest, Hungary, 1125
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Budapest, Hungary, 1134
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Budapest, Hungary, 1204
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Budapest, Hungary, 1101
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Budapest, Hungary, 1117
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Budapest, Hungary, 1191
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Debrecen, Hungary, 4031
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Debrecen, Hungary, 4026
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Gyula, Hungary, 5703
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Kaposvár, Hungary, 7400
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Komarom, Hungary, 2900
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Komló, Hungary, 7300
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Mosonmagyaróvár, Hungary, 9200
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Nagykanizsa, Hungary, 8800
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Nyiregyhaza, Hungary, 4400
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Pécs, Hungary, 7635
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Sopron, Hungary, 9400
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Szigetszentmiklos, Hungary, 2310
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Szikszó, Hungary, H-3800
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Szombathely, Hungary, 9700
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Tatabanya, Hungary, 2800
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Vasarosnameny, Hungary, 4800
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Zalaegerszeg, Hungary, 8900
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Ahmedabad, India, 380052
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Ahmedabad, India, 380007
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Alappuzha, India, 688524
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Angamaly, India, 683 572
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Aurangabad, India, 431001
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Bangalore, India, 560 010
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Bangalore, India, 560 054
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Bangalore, India, 560034
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Bangalore, India, 560076
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Chennai, India, 600034
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Chennai, India, 600100
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Guntur, India, 522001
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Hyderabad, India, 500004
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Hyderabad, India, 500035
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Hyderabad, India, 500038
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Jaipur, India, 302006
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Jaipur, India, 302022
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Lucknow, India, 226018
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Mysore, India, 570004
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Mysore, India, 570002
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Nagpur, India, 440012
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Nagpur, India, 440019
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Nashik, India, 422007
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Nasik, India, 422005
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Pune, India, 411014
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Pune, India, 411015
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Trisshur, India, 680 002
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Trivandrum, India, 695004
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Varanasi, India, 221005
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Varanasi, India, 221001
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Vijayawada, India, 520002
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Banda Aceh, Indonesia, 23126
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Banjarmasin, Indonesia, 70233
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Bukittinggi, Indonesia, 26117
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Denpasar, Indonesia, 80114
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Depok Timur, Indonesia, 16411
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Jakarta, Indonesia, 12430
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Jakarta, Indonesia, 13230
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Jakarta, Indonesia, 13630
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Lampung Selatan, Indonesia, 35373
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Makassar, Indonesia, 90245
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Malang, Indonesia, 65100
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Medan, Indonesia, 20111
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Medan, Indonesia, 20154
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Padang, Indonesia, 25127
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Palembang, Indonesia, 30126
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Pekanbaru, Indonesia, 28133
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Pontianak, Indonesia, 78122
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Pringsewu, Indonesia, 35373
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Semarang, Indonesia, 50242
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Surabaya, Indonesia, 60286
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Surakarta, Indonesia, 57126
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Yogyakarta, Indonesia, 55283
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Afula, Israel, 18101
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Ashkelon, Israel, 78306
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Beer-Sheba, Israel, 84101
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Hadera, Israel, PO Box 169
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Haifa, Israel, 31096
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Haifa, Israel, 34362
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Holon, Israel, 68125
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Jerusalem, Israel, 91120
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Kfar Saba, Israel, 44281
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Rehovot, Israel, 76100
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Tel Aviv, Israel, 64239
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Tel Hashomer, Israel, 52621
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Friuli-Venezia-Giulia
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Pordenone, Friuli-Venezia-Giulia, Italy, 33170
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Aichi, Japan, 457-8511
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Aichi, Japan, 457-8510
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Aichi, Japan, 454-8502
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Fukuoka, Japan, 832-0059
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Gifu, Japan, 500-8717
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Hokkaido, Japan, 060-0033
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Hokkaido, Japan, 070-8644
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Hokkaido, Japan, 053-8506
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Hyogo, Japan, 650-0047
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Ibaraki, Japan, 319-1113
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Kagawa, Japan, 762-0031
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Kodaira, Japan, 187-0002
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Kumamoto, Japan, 861-1196
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Kyoto, Japan, 607-8062
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Oita, Japan, 876-0047
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Osaka, Japan, 530-0001
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Osaka, Japan, 558-8558
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Osaka, Japan, 591-8555
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Shimane, Japan, 690-8556
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Shimane, Japan, 690-8509
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Tokyo, Japan, 103-0027
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Tokyo, Japan, 103-0028
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Tokyo, Japan, 194-0023
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Bucheon, Korea, Republic of, 420-717
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Bucheon-Si, Gyeonggi-Do, Korea, Republic of, 420-021
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Busan, Korea, Republic of, 602-715
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Cheonan, Korea, Republic of, 330-721
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Chonju-si, Korea, Republic of, 561-712
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Daegu, Korea, Republic of, 705-717
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Daejeon, Korea, Republic of, 301-721
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Daejeon, Korea, Republic of, 301-723
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Goyang-si, Korea, Republic of, 411706
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Guri-si, Korea, Republic of, 471-701
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Gwangju, Korea, Republic of, 501-757
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Gyeonggi-do, Korea, Republic of, 410-719
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Incheon, Korea, Republic of, 400-711
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Incheon, Korea, Republic of, 403-720
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Kangwon, Korea, Republic of, 200-722
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Seongnam, Korea, Republic of, 463-712
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Seoul, Korea, Republic of, 135-720
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Seoul, Korea, Republic of, 136-705
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Seoul, Korea, Republic of, 130-709
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Seoul, Korea, Republic of, 152-703
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Seoul, Korea, Republic of
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Seoul, Korea, Republic of, 133--792
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Seoul, Korea, Republic of, 158-710
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Seoul, Korea, Republic of, 150-713
- GSK Investigational Site
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Seoul, Korea, Republic of, 130-872
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Seoul, Korea, Republic of, 380-704
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Seoul, Korea, Republic of, 110-746
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Seoul, Korea, Republic of, 139-711
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Seoul, Korea, Republic of, 100-030
- GSK Investigational Site
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Seoul, Korea, Republic of, 139-707
- GSK Investigational Site
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Seoul, Korea, Republic of, 140-887
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Suwon, Gyeonggi-do, Korea, Republic of, 442-723
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Uijeongbu, Gyeonggi-do, Korea, Republic of, 480-717
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Ulsan, Korea, Republic of, 682-714
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Wonju-si, Kanwon-do, Korea, Republic of, 220-701
- GSK Investigational Site
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Balvi, Latvia, LV - 4501
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Daugavpils, Latvia, LA-5403
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Daugavpils, Latvia, LV5410
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Jekabpils, Latvia, LV 5201
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Jelgava, Latvia, LV - 3001
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Jurmala, Latvia, LV-2010
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Kraslava, Latvia, LV - 5601
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Kuldiga, Latvia, LV - 3301
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Liepaja, Latvia, LV 3414
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Ogre, Latvia, LV - 5001
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Riga, Latvia, LV 1002
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Riga, Latvia, LV-1010
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Riga, Latvia, LV 1003
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Riga, Latvia, LV1001
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Riga, Latvia, LV1038
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Talsi, Latvia, LV - 3201
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Tukums, Latvia, LV - 3101
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Valmiera, Latvia, LV-4201
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Ventspils, Latvia, LV3601
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Bitola, Macedonia, The Former Yugoslav Republic of, 7000
- GSK Investigational Site
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Gostivar, Macedonia, The Former Yugoslav Republic of, 1230
- GSK Investigational Site
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Ohrid, Macedonia, The Former Yugoslav Republic of, 6000
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Prilep, Macedonia, The Former Yugoslav Republic of, 7500
- GSK Investigational Site
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Shtip, Macedonia, The Former Yugoslav Republic of, 2000
- GSK Investigational Site
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Skopje, Macedonia, The Former Yugoslav Republic of, 1000
- GSK Investigational Site
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Strumica, Macedonia, The Former Yugoslav Republic of, 2400
- GSK Investigational Site
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Veles, Macedonia, The Former Yugoslav Republic of, 1400
- GSK Investigational Site
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Johor Bahru, Malaysia, 80100
- GSK Investigational Site
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Kuala Lumpur, Malaysia, 50590
- GSK Investigational Site
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Kuala Pilah, Malaysia, 72000
- GSK Investigational Site
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Kuching, Malaysia, 93586
- GSK Investigational Site
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Selangor, Malaysia, 68100
- GSK Investigational Site
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Sibu, Malaysia, 96000
- GSK Investigational Site
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Sungai Petani, Kedah, Malaysia, 08000
- GSK Investigational Site
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Taiping Perak, Malaysia, 34000
- GSK Investigational Site
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Aguascalientes, Mexico, 20127
- GSK Investigational Site
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Chihuahua, Mexico, 31203
- GSK Investigational Site
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Chihuahua, Mexico, 31238
- GSK Investigational Site
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Guadalajara, Mexico, 44670
- GSK Investigational Site
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Hidalgo, Mexico, 42070
- GSK Investigational Site
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Merida, Mexico, 97000
- GSK Investigational Site
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Mexico D.F, Mexico, 6700
- GSK Investigational Site
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Monterrey, Mexico, 64060
- GSK Investigational Site
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México DF, Mexico, 14050
- GSK Investigational Site
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San luis Potosí, Mexico, 78090
- GSK Investigational Site
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Estado De México
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Cuautitlan Izcalli, Estado De México, Mexico, 54769
- GSK Investigational Site
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Jalisco
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Guadalajara, Jalisco, Mexico, 44500
- GSK Investigational Site
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Zapopan, Jalisco, Mexico, 45040
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Michoacán
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Morelia, Michoacán, Mexico, C.P. 58249
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Morelos
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Cuernavaca, Morelos, Mexico, 62350
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Nuevo León
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Monterrey, Nuevo León, Mexico, 64460
- GSK Investigational Site
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Monterrey, Nuevo León, Mexico, 64710
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Sonora
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Hermosillo, Sonora, Mexico, 83000
- GSK Investigational Site
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Alkmaar, Netherlands, 1815 JD
- GSK Investigational Site
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Almelo, Netherlands, 7609 PP
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Ede Gld, Netherlands, 6717RP
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Helmond, Netherlands, 5707 HA
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Zutphen, Netherlands, 7207 AE
- GSK Investigational Site
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Alabang, Muntinlupa City, Philippines, 1780
- GSK Investigational Site
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Caloocan, Philippines, 1400
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Cavite, Philippines, 4114
- GSK Investigational Site
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Cebu City, Philippines, 6000
- GSK Investigational Site
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Dasmariñas, Cavite, Philippines, 4114
- GSK Investigational Site
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Davao, Philippines, 8000
- GSK Investigational Site
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Iloilo, Philippines, 5000
- GSK Investigational Site
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Iloilo City, Philippines, 5000
- GSK Investigational Site
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Jaro, Iloilo City, Philippines, 5000
- GSK Investigational Site
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Los Banos, Philippines, 4030
- GSK Investigational Site
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Manila, Philippines, 1000
- GSK Investigational Site
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Manila, Philippines, 1012
- GSK Investigational Site
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Marilao, Bulacan, Philippines, 3019
- GSK Investigational Site
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Pasay, Philippines, 1300
- GSK Investigational Site
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Pasig, Philippines, 1605
- GSK Investigational Site
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Quezon, Philippines, 1104
- GSK Investigational Site
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Quezon City, Philippines, 1102
- GSK Investigational Site
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Quezon City, Philippines, 1100
- GSK Investigational Site
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Quezon City, Philippines, 1109
- GSK Investigational Site
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Quezon City, Philippines, 1108
- GSK Investigational Site
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San Fernando, Pampanga, Philippines, 2000
- GSK Investigational Site
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Bialystok, Poland, 15-044
- GSK Investigational Site
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Bialystok, Poland, 15-003
- GSK Investigational Site
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Bielsko-Biala, Poland, 43-300
- GSK Investigational Site
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Bielsko-Biala, Poland, 43-316
- GSK Investigational Site
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Bienkowka, Poland, 34-212
- GSK Investigational Site
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Bydgoszcz, Poland, 85-681
- GSK Investigational Site
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Bydgoszcz, Poland, 85-863
- GSK Investigational Site
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Chelmza, Poland, 87-140
- GSK Investigational Site
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Chodziez, Poland, 64-800
- GSK Investigational Site
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Chorzow, Poland, 41-500
- GSK Investigational Site
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Choszczno, Poland, 73-200
- GSK Investigational Site
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Czestochowa, Poland, 42-200
- GSK Investigational Site
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Dabrowa Gornicza, Poland, 41-300
- GSK Investigational Site
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Dzialdowo, Poland, 13-200
- GSK Investigational Site
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Elblag, Poland, 82-300
- GSK Investigational Site
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Gdansk, Poland, 80-405
- GSK Investigational Site
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Gdansk, Poland, 80-286
- GSK Investigational Site
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Gdansk, Poland, 80-433
- GSK Investigational Site
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Gdynia, Poland, 81-384
- GSK Investigational Site
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Gorzow Wielkopolski, Poland, 66-400
- GSK Investigational Site
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Grudziadz, Poland, 86-300
- GSK Investigational Site
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Ilawa, Poland, 14-200
- GSK Investigational Site
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Inowroclaw, Poland, 88-100
- GSK Investigational Site
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Izabelin, Poland, 05-080
- GSK Investigational Site
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Jelenia Gora, Poland, 58-506
- GSK Investigational Site
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Karpacz, Poland, 58-540
- GSK Investigational Site
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Katowice, Poland, 40-040
- GSK Investigational Site
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Katowice, Poland, 40-954
- GSK Investigational Site
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Kielce, Poland, 25-734
- GSK Investigational Site
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Kielce, Poland, 25-030
- GSK Investigational Site
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Kielce, Poland, 25-365
- GSK Investigational Site
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Krakow, Poland, 31-024
- GSK Investigational Site
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Krakow, Poland, 31-530
- GSK Investigational Site
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Krakow, Poland, 31-637
- GSK Investigational Site
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Krakow, Poland, 31-455
- GSK Investigational Site
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Krakow, Poland, 31-567
- GSK Investigational Site
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Krakow, Poland, 31-913
- GSK Investigational Site
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Krotoszyn, Poland, 63-700
- GSK Investigational Site
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Ksawerow, Poland, 95-054
- GSK Investigational Site
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Kutno, Poland, 99-300
- GSK Investigational Site
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Libiaz, Poland, 32-590
- GSK Investigational Site
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Lodz, Poland, 90-153
- GSK Investigational Site
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Lodz, Poland, 93-329
- GSK Investigational Site
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Lodz, Poland, 90-203
- GSK Investigational Site
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Lodz, Poland, 90-302
- GSK Investigational Site
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Lodz, Poland, 90-430
- GSK Investigational Site
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Lodz, Poland, 91-849
- GSK Investigational Site
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Lodz, Poland, 92-107
- GSK Investigational Site
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Lodz, Poland, 92-215
- GSK Investigational Site
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Lodz, Poland, 93-113
- GSK Investigational Site
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Lodz, Poland, 94-050
- GSK Investigational Site
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Lublin, Poland, 20-093
- GSK Investigational Site
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Lublin, Poland, 20-718
- GSK Investigational Site
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Lublin, Poland, 20-552
- GSK Investigational Site
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Olawa, Poland, 55-200
- GSK Investigational Site
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Olsztyn, Poland, 10-357
- GSK Investigational Site
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Ostrow Wilekopolski, Poland, 63-400
- GSK Investigational Site
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Ostrowiec Swietokrzyski, Poland, 27-400
- GSK Investigational Site
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Piaseczno, Poland, 05-500
- GSK Investigational Site
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Pila, Poland, 64-920
- GSK Investigational Site
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Plock, Poland, 09-402
- GSK Investigational Site
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Police, Poland, 72-010
- GSK Investigational Site
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Poznan, Poland, 60-214
- GSK Investigational Site
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Poznan, Poland, 60-569
- GSK Investigational Site
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Poznan, Poland, 60-773
- GSK Investigational Site
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Poznan, Poland, 60-823
- GSK Investigational Site
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Ruda Slaska, Poland, 41-709
- GSK Investigational Site
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Rudka, Poland, 05-320
- GSK Investigational Site
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Rzeszow, Poland, 35-301
- GSK Investigational Site
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Skarzysko-Kamienna, Poland, 26-110
- GSK Investigational Site
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Skierniewice, Poland, 96-100
- GSK Investigational Site
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Slupsk, Poland, 76-200
- GSK Investigational Site
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Sopot, Poland, 81- 717
- GSK Investigational Site
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Swidnik, Poland, 21-040
- GSK Investigational Site
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Szczecin, Poland, 70-111
- GSK Investigational Site
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Szczecin, Poland, 71-124
- GSK Investigational Site
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Tarnow, Poland, 33-100
- GSK Investigational Site
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Tczew, Poland, 83-110
- GSK Investigational Site
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Torun, Poland, 87100
- GSK Investigational Site
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Warszawa, Poland, 01-138
- GSK Investigational Site
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Warszawa, Poland, 01-192
- GSK Investigational Site
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Warszawa, Poland, 01-868
- GSK Investigational Site
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Warszawa, Poland, 01-157
- GSK Investigational Site
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Wloclawek, Poland, 87-800
- GSK Investigational Site
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Wloszczowa, Poland, 29-100
- GSK Investigational Site
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Wodzislaw Slaski, Poland, 44-300
- GSK Investigational Site
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Wroclaw, Poland, 54-239
- GSK Investigational Site
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Wroclaw, Poland, 50-044
- GSK Investigational Site
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Wroclaw, Poland, 50-088
- GSK Investigational Site
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Wroclaw, Poland, 53-301
- GSK Investigational Site
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Wroclaw, Poland, 53-439
- GSK Investigational Site
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Zabrze, Poland, 41-800
- GSK Investigational Site
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Zabrze, Poland, 41-807
- GSK Investigational Site
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Zgierz, Poland, 95-100
- GSK Investigational Site
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Łęczyca, Poland, 99-100
- GSK Investigational Site
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Arad, Romania, 310013
- GSK Investigational Site
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Bacau, Romania, 600252
- GSK Investigational Site
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Bragadiru, Romania, 077025
- GSK Investigational Site
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Brasov, Romania, 500283
- GSK Investigational Site
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Brasov, Romania, 500086
- GSK Investigational Site
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Bucarest, Romania, 050159
- GSK Investigational Site
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Bucharest, Romania, 050159
- GSK Investigational Site
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Bucharest, Romania, 020125
- GSK Investigational Site
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Bucharest, Romania, 011794
- GSK Investigational Site
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Bucharest, Romania, 030303
- GSK Investigational Site
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Bucuresti, Romania, 022328
- GSK Investigational Site
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Bucuresti, Romania, 030303
- GSK Investigational Site
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Bucuresti, Romania, 011025
- GSK Investigational Site
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Bucuresti, Romania, 012384
- GSK Investigational Site
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Bucuresti, Romania, 014461
- GSK Investigational Site
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Bucuresti, Romania, 020475
- GSK Investigational Site
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Bucuresti, Romania, 021659
- GSK Investigational Site
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Bucuresti, Romania, 040206
- GSK Investigational Site
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Bucuresti, Romania, 050159
- GSK Investigational Site
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Bucuresti, Romania, 050554
- GSK Investigational Site
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Bucuresti, Romania, 050722
- GSK Investigational Site
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Bucuresti, Romania, 10825
- GSK Investigational Site
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Campulung Muscel, Romania, 115100
- GSK Investigational Site
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Cluj-Napoca, Romania, 400371
- GSK Investigational Site
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Cluj-Napoca, Romania, 400352
- GSK Investigational Site
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Codlea, Romania, 505100
- GSK Investigational Site
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Constanta, Romania, 900002
- GSK Investigational Site
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Constanta, Romania, 900004
- GSK Investigational Site
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Deva, Romania, 330084
- GSK Investigational Site
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Iasi, Romania, 700503
- GSK Investigational Site
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Iasi, Romania, 700141
- GSK Investigational Site
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Iasi, Romania, 700381
- GSK Investigational Site
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Iasi, Romania, 700656
- GSK Investigational Site
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Pitesti, Romania, 110084
- GSK Investigational Site
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Pitesti, Romania, 110283
- GSK Investigational Site
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Ploiesti, Romania, 100184
- GSK Investigational Site
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Ramnicu Valcea, Romania, 240564
- GSK Investigational Site
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Suceava, Romania, 720284
- GSK Investigational Site
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Targu-Mures, Romania, 540142
- GSK Investigational Site
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Timisoara, Romania, 300310
- GSK Investigational Site
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Timisoara, Romania, 300736
- GSK Investigational Site
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Arkhangelsk, Russian Federation, 163001
- GSK Investigational Site
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Arkhangelsk, Russian Federation, 163061
- GSK Investigational Site
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Barnaul, Russian Federation, 656024
- GSK Investigational Site
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Barnaul, Russian Federation, 656038
- GSK Investigational Site
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Chelyabinsk, Russian Federation, 454021
- GSK Investigational Site
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Chelyabinsk, Russian Federation, 454047
- GSK Investigational Site
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Chelyabinsk, Russian Federation, 454091
- GSK Investigational Site
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Ekaterinburg, Russian Federation, 620137
- GSK Investigational Site
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Ekaterinburg, Russian Federation, 620109
- GSK Investigational Site
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Ekaterinburg, Russian Federation, 620149
- GSK Investigational Site
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Gatchina, Russian Federation, 188300
- GSK Investigational Site
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Ivanovo, Russian Federation, 153462
- GSK Investigational Site
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Izhevsk, Russian Federation, 426063
- GSK Investigational Site
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Kaliningrad, Russian Federation, 236016
- GSK Investigational Site
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Kazan, Russian Federation, 420012
- GSK Investigational Site
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Kemerovo, Russian Federation, 650000
- GSK Investigational Site
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Kemerovo, Russian Federation, 650002
- GSK Investigational Site
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Kirov, Russian Federation, 610027
- GSK Investigational Site
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Krasnoyarsk, Russian Federation, 660022
- GSK Investigational Site
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Kursk, Russian Federation, 305035
- GSK Investigational Site
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Moscow, Russian Federation, 123182
- GSK Investigational Site
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Moscow, Russian Federation, 119049
- GSK Investigational Site
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Moscow, Russian Federation, 117292
- GSK Investigational Site
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Moscow, Russian Federation, 117997
- GSK Investigational Site
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Moscow, Russian Federation, 115478
- GSK Investigational Site
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Moscow, Russian Federation, 119991
- GSK Investigational Site
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Moscow, Russian Federation, 111539
- GSK Investigational Site
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Moscow, Russian Federation, 119620
- GSK Investigational Site
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Moscow, Russian Federation, 121 309
- GSK Investigational Site
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Moscow, Russian Federation, 127018
- GSK Investigational Site
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Moscow, Russian Federation, 115 280
- GSK Investigational Site
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Moscow, Russian Federation, 129301
- GSK Investigational Site
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Moscow, Russian Federation, 117593
- GSK Investigational Site
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Moscow, Russian Federation, 105066
- GSK Investigational Site
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Moscow, Russian Federation, 115093
- GSK Investigational Site
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Moscow, Russian Federation, 119002
- GSK Investigational Site
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Moscow, Russian Federation, 125299
- GSK Investigational Site
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Moscow, Russian Federation, 107392
- GSK Investigational Site
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Moscow, Russian Federation, 109263
- GSK Investigational Site
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Moscow, Russian Federation, 111111
- GSK Investigational Site
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Moscow, Russian Federation, 115432
- GSK Investigational Site
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Moscow, Russian Federation, 115516
- GSK Investigational Site
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Moscow, Russian Federation, 115682
- GSK Investigational Site
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Moscow, Russian Federation, 117630
- GSK Investigational Site
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Moscow, Russian Federation, 119048
- GSK Investigational Site
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Moscow, Russian Federation, 119121
- GSK Investigational Site
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Moscow, Russian Federation, 119229
- GSK Investigational Site
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Moscow, Russian Federation, 121374
- GSK Investigational Site
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Moscow, Russian Federation, 123060
- GSK Investigational Site
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Moscow, Russian Federation, 125205
- GSK Investigational Site
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Moscow, Russian Federation, 129090
- GSK Investigational Site
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Nizhniy Novgorod, Russian Federation, 603035
- GSK Investigational Site
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Novosibirsk, Russian Federation, 630099
- GSK Investigational Site
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Novosibirsk, Russian Federation, 630087
- GSK Investigational Site
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Novosibirsk, Russian Federation, 630091
- GSK Investigational Site
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Novosibirsk, Russian Federation, 630008
- GSK Investigational Site
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Novosibirsk, Russian Federation, 630051
- GSK Investigational Site
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Novosibirsk, Russian Federation, 630075
- GSK Investigational Site
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Novosibirsk, Russian Federation
- GSK Investigational Site
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Orenburg, Russian Federation, 460000
- GSK Investigational Site
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Orenburg, Russian Federation, 460018
- GSK Investigational Site
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Perm, Russian Federation, 614070
- GSK Investigational Site
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Perm, Russian Federation, 614097
- GSK Investigational Site
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Perm, Russian Federation, 614111
- GSK Investigational Site
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Pskov, Russian Federation, 180016
- GSK Investigational Site
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Rostov-on-Don, Russian Federation, 344022
- GSK Investigational Site
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Ryazan, Russian Federation, 390026
- GSK Investigational Site
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Ryazan, Russian Federation, 390039
- GSK Investigational Site
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Ryazan, Russian Federation, 390005
- GSK Investigational Site
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Saint Petersburg, Russian Federation, 192177
- GSK Investigational Site
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Saint Petersburg, Russian Federation, 197022
- GSK Investigational Site
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Saint Petersburg, Russian Federation, 194044
- GSK Investigational Site
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Saint Petersburg, Russian Federation, 195257
- GSK Investigational Site
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Saint Petersburg, Russian Federation, 196084
- GSK Investigational Site
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Saint Petersburg, Russian Federation, 198103
- GSK Investigational Site
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Saint-Petersburg, Russian Federation, 194354
- GSK Investigational Site
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Saint-Petersburg, Russian Federation, 198328
- GSK Investigational Site
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Saint-Petersburg, Russian Federation, 198260
- GSK Investigational Site
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Saint-Petersburg, Russian Federation, 195112
- GSK Investigational Site
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Saint-Petersburg, Russian Federation, 196084
- GSK Investigational Site
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Saint-Petersburg, Russian Federation, 196601
- GSK Investigational Site
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Saratov, Russian Federation, 410028
- GSK Investigational Site
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Saratov, Russian Federation, 410012
- GSK Investigational Site
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Saratov, Russian Federation, 410054
- GSK Investigational Site
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Saratov, Russian Federation, 410018
- GSK Investigational Site
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Saratov, Russian Federation, 410039
- GSK Investigational Site
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Sestroretsk, Russian Federation, 197706
- GSK Investigational Site
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Smolensk, Russian Federation, 214006
- GSK Investigational Site
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Smolensk, Russian Federation, 214 019
- GSK Investigational Site
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St Petersburg, Russian Federation, 192283
- GSK Investigational Site
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St Petersburg, Russian Federation, 194354
- GSK Investigational Site
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St'Petersburg, Russian Federation, 193312
- GSK Investigational Site
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St-Petersburg, Russian Federation, 194017
- GSK Investigational Site
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St-Petersburg, Russian Federation, 193312
- GSK Investigational Site
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St-Petersburg, Russian Federation, 199106
- GSK Investigational Site
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St. Petersburg, Russian Federation, 194356
- GSK Investigational Site
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St. Petersburg, Russian Federation, 197022
- GSK Investigational Site
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St. Petersburg, Russian Federation, 190103
- GSK Investigational Site
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St. Petersburg, Russian Federation, 191015
- GSK Investigational Site
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St.Petersburg, Russian Federation, 191025
- GSK Investigational Site
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St.Petersburg, Russian Federation, 197089
- GSK Investigational Site
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St.Рetersburg, Russian Federation, 198035
- GSK Investigational Site
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Tomsk, Russian Federation, 634063
- GSK Investigational Site
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Tomsk, Russian Federation, 634050
- GSK Investigational Site
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Tomsk, Russian Federation, 634 050
- GSK Investigational Site
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Tomsk, Russian Federation, 634012
- GSK Investigational Site
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Tver, Russian Federation, 170036
- GSK Investigational Site
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Ufa, Russian Federation, 450071
- GSK Investigational Site
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Ulyanovsk, Russian Federation, 432063
- GSK Investigational Site
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Voronezh, Russian Federation, 394066
- GSK Investigational Site
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Voronezh, Russian Federation, 394018
- GSK Investigational Site
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Vsevolzhsk, Russian Federation, 188640
- GSK Investigational Site
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Yaroslavl, Russian Federation, 150003
- GSK Investigational Site
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Yaroslavl, Russian Federation, 150023
- GSK Investigational Site
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Yaroslavl, Russian Federation, 150062
- GSK Investigational Site
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Yaroslavl, Russian Federation, 150010
- GSK Investigational Site
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Yaroslavl, Russian Federation, 150002
- GSK Investigational Site
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Belgrade, Serbia, 11000
- GSK Investigational Site
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Belgrade, Serbia, 11080
- GSK Investigational Site
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Cacak, Serbia, 32000
- GSK Investigational Site
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Kragujevac, Serbia, 34000
- GSK Investigational Site
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Nis, Serbia, 18000
- GSK Investigational Site
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Sombor, Serbia, 25000
- GSK Investigational Site
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Sremska Kamenica, Serbia, 21204
- GSK Investigational Site
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Valjevo, Serbia, 14000
- GSK Investigational Site
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Bratislava, Slovakia, 851 01
- GSK Investigational Site
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Bratislava, Slovakia, 841 08
- GSK Investigational Site
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Bratislava, Slovakia, 821 06
- GSK Investigational Site
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Bratislava, Slovakia, 841 04
- GSK Investigational Site
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Kosice, Slovakia, 040 01
- GSK Investigational Site
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Kralovsky Chlmec, Slovakia, 077 01
- GSK Investigational Site
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Nove Zamky, Slovakia, 940 01
- GSK Investigational Site
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Presov, Slovakia, 080 01
- GSK Investigational Site
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Presov, Slovakia, 081 81
- GSK Investigational Site
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Spisska Nova Ves, Slovakia, 052 01
- GSK Investigational Site
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Sturovo, Slovakia, 943 01
- GSK Investigational Site
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Trnava, Slovakia, 917 01
- GSK Investigational Site
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Vrable, Slovakia, 952 01
- GSK Investigational Site
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Benoni, South Africa, 1501
- GSK Investigational Site
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Bloemfontein, South Africa, 9301
- GSK Investigational Site
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Cape Town, South Africa, 7500
- GSK Investigational Site
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Cape Town, South Africa, 7700
- GSK Investigational Site
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Cape Town, South Africa, 7572
- GSK Investigational Site
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Cape Town, South Africa, 8001
- GSK Investigational Site
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Cape Town, South Africa, 7441
- GSK Investigational Site
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CapeTown, South Africa, 7764
- GSK Investigational Site
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Durban, South Africa, 4001
- GSK Investigational Site
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Durban, South Africa, 4071
- GSK Investigational Site
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Gatesville, South Africa, 7764
- GSK Investigational Site
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Johannesburg, South Africa, 1686
- GSK Investigational Site
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Korsten, South Africa, 6014
- GSK Investigational Site
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Lynnwood Ridge, South Africa, 0014
- GSK Investigational Site
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Mowbray, South Africa, 7700
- GSK Investigational Site
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Paarl, South Africa, 7646
- GSK Investigational Site
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Panorama, South Africa, 7500
- GSK Investigational Site
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Potchefstroom, South Africa, 2531
- GSK Investigational Site
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Pretoria, South Africa, 0002
- GSK Investigational Site
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Pretoria, South Africa, 0022
- GSK Investigational Site
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Roodepoort, South Africa, 1724
- GSK Investigational Site
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Rooihuiskraal, South Africa, 158
- GSK Investigational Site
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Somerset West, South Africa, 7130
- GSK Investigational Site
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Thabazimbi, South Africa, 0380
- GSK Investigational Site
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Tygerberg, South Africa, 7505
- GSK Investigational Site
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Voorspoed, South Africa, 9459
- GSK Investigational Site
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Gauteng
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Benoni, Gauteng, South Africa, 1501
- GSK Investigational Site
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Boksburg, Gauteng, South Africa, 1459
- GSK Investigational Site
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Meyerspark, Gauteng, South Africa, 0184
- GSK Investigational Site
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Morningside, Gauteng, South Africa, 2057
- GSK Investigational Site
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Pretoria, Gauteng, South Africa, 0084
- GSK Investigational Site
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Pretoria, Gauteng, South Africa, 0183
- GSK Investigational Site
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Pretoria, Gauteng, South Africa, 0041
- GSK Investigational Site
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Pretoria, Gauteng, South Africa, 0181
- GSK Investigational Site
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Thaba Tshwane, Gauteng, South Africa, 0143
- GSK Investigational Site
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KwaZulu- Natal
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Dundee, KwaZulu- Natal, South Africa, 3000
- GSK Investigational Site
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Mpumalanga
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Middelburg, Mpumalanga, South Africa, 1055
- GSK Investigational Site
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Badalona, Spain, 08916
- GSK Investigational Site
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Barcelona, Spain, 08025
- GSK Investigational Site
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Barcelona, Spain, 08036
- GSK Investigational Site
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Barcelona, Spain, 08022
- GSK Investigational Site
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Barcelona, Spain, 08041
- GSK Investigational Site
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Benidorm, Spain, 03501
- GSK Investigational Site
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Canet De Mar - Barcelona, Spain, 08360
- GSK Investigational Site
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Galdakano, Spain, 48960
- GSK Investigational Site
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Illescas-Toledo, Spain, 45200
- GSK Investigational Site
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Jerez de la Frontera, Spain, 11407
- GSK Investigational Site
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L'Hospitalet de Llobregat, Spain, 08907
- GSK Investigational Site
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Madrid, Spain, 28040
- GSK Investigational Site
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Madrid, Spain, 28046
- GSK Investigational Site
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Mataró, Spain, 08303
- GSK Investigational Site
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Oviedo, Spain, 33006
- GSK Investigational Site
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Palma de Mallorca, Spain, 07010
- GSK Investigational Site
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Pamplona, Spain, 31008
- GSK Investigational Site
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Pozuelo De Alarcón/Madrid, Spain, 28223
- GSK Investigational Site
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Sabadell (Barcelona), Spain, 08208
- GSK Investigational Site
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Sagunto/Valencia, Spain, 46520
- GSK Investigational Site
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Sant Boi de Llobregat, Spain, 08830
- GSK Investigational Site
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Santa Coloma de Gramenet, Spain, 08921
- GSK Investigational Site
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Santiago de Compostela, Spain, 15706
- GSK Investigational Site
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Torrelavega, Spain, 39300
- GSK Investigational Site
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Valencia, Spain, 46017
- GSK Investigational Site
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Vic (Barcelona), Spain, 08500
- GSK Investigational Site
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Changhua, Taiwan, 500
- GSK Investigational Site
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Chia-Yi, Taiwan, 613
- GSK Investigational Site
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Kaohsiung, Taiwan, 807
- GSK Investigational Site
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Kaohsiung Hsien, Taiwan, 833
- GSK Investigational Site
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Keelung, Taiwan, 20401
- GSK Investigational Site
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LinKou, Taiwan, 333
- GSK Investigational Site
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Taichung, Taiwan, 404
- GSK Investigational Site
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Taichung, Taiwan, 40705
- GSK Investigational Site
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Taichung, Taiwan, 40201
- GSK Investigational Site
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Taichung, Taiwan, 433
- GSK Investigational Site
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Taichung, Taiwan, 437
- GSK Investigational Site
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Tainan, Taiwan, 704
- GSK Investigational Site
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Taipei, Taiwan
- GSK Investigational Site
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Taipei, Taiwan, 220
- GSK Investigational Site
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Taipei, Taiwan, 106
- GSK Investigational Site
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Taipei, Taiwan, 115
- GSK Investigational Site
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Taipei, Taiwan, 235
- GSK Investigational Site
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Yung Kang City, Taiwan, 71044
- GSK Investigational Site
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Bangkok, Thailand, 10400
- GSK Investigational Site
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Bangkok, Thailand, 10330
- GSK Investigational Site
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Bangkok, Thailand, 10700
- GSK Investigational Site
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Bangkok, Thailand, 10600
- GSK Investigational Site
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Bangkok, Thailand, 10220
- GSK Investigational Site
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Chiangmai, Thailand, 50200
- GSK Investigational Site
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Chiangrai, Thailand, 57000
- GSK Investigational Site
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Khon Kaen, Thailand, 40002
- GSK Investigational Site
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Mae Rim, Chiang Mai, Thailand, 50180
- GSK Investigational Site
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Muang, Thailand, 11000
- GSK Investigational Site
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Muang Phitsanulok, Thailand, 53000
- GSK Investigational Site
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Nakhon Ratchasima, Thailand, 30000
- GSK Investigational Site
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Phitsanulok, Thailand, 65000
- GSK Investigational Site
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Songkla, Thailand, 90110
- GSK Investigational Site
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Ankara, Turkey, 06500
- GSK Investigational Site
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Ankara, Turkey, 06590
- GSK Investigational Site
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Ankara, Turkey, 06280
- GSK Investigational Site
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Ankara, Turkey, 06510
- GSK Investigational Site
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Ankara, Turkey, 6030
- GSK Investigational Site
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Bursa, Turkey, 16059
- GSK Investigational Site
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Istanbul, Turkey, 34020
- GSK Investigational Site
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Istanbul, Turkey, 34844
- GSK Investigational Site
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Istanbul, Turkey, 34899
- GSK Investigational Site
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Istanbul, Turkey, 61080
- GSK Investigational Site
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Kocaeli, Turkey, 41380
- GSK Investigational Site
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Konya, Turkey, 42080
- GSK Investigational Site
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Samsun, Turkey, 55139
- GSK Investigational Site
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İstanbul, Turkey, 34098
- GSK Investigational Site
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Alupka, Ukraine, 98676
- GSK Investigational Site
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Cherkassy, Ukraine, 18009
- GSK Investigational Site
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Chernihiv, Ukraine, 14034
- GSK Investigational Site
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Chernivtsi, Ukraine, 58022
- GSK Investigational Site
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Dnipropetrovsk, Ukraine, 49074
- GSK Investigational Site
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Dnipropetrovsk, Ukraine, 49027
- GSK Investigational Site
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Dnipropetrovsk, Ukraine, 49102
- GSK Investigational Site
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Dnipropetrovsk, Ukraine, 49005
- GSK Investigational Site
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Dnipropetrovsk, Ukraine, 49064
- GSK Investigational Site
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Donetsk, Ukraine, 83003
- GSK Investigational Site
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Donetsk, Ukraine, 83114
- GSK Investigational Site
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Donetsk, Ukraine, 83045
- GSK Investigational Site
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Donetsk, Ukraine, 83059
- GSK Investigational Site
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Ivano-Frankivsk, Ukraine, 76008
- GSK Investigational Site
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Ivano-Frankivsk, Ukraine, 76018
- GSK Investigational Site
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Ivano-Frankivsk, Ukraine, 76005
- GSK Investigational Site
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Kharkiv, Ukraine, 61124
- GSK Investigational Site
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Kharkiv, Ukraine, 61039
- GSK Investigational Site
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Kharkiv, Ukraine, 61002
- GSK Investigational Site
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Kharkiv, Ukraine, 61018
- GSK Investigational Site
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Kharkiv, Ukraine, 61022
- GSK Investigational Site
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Kharkiv, Ukraine, 61001
- GSK Investigational Site
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Kharkiv, Ukraine, 61046
- GSK Investigational Site
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Kharkiv, Ukraine, 61103
- GSK Investigational Site
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Kharkiv, Ukraine, 61157
- GSK Investigational Site
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Kherson, Ukraine, 73000
- GSK Investigational Site
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Kiev, Ukraine, 03680
- GSK Investigational Site
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Kiev, Ukraine, 02660
- GSK Investigational Site
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Kryvyi Rig, Ukraine, 50096
- GSK Investigational Site
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Kyiv, Ukraine, 03680
- GSK Investigational Site
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Kyiv, Ukraine, 03038
- GSK Investigational Site
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Kyiv, Ukraine, 03049
- GSK Investigational Site
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Kyiv, Ukraine, 04114
- GSK Investigational Site
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Kyiv, Ukraine, 04201
- GSK Investigational Site
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Kyiv, Ukraine, 03179
- GSK Investigational Site
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Kyiv, Ukraine, 1680
- GSK Investigational Site
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Kyiv, Ukraine, 4050
- GSK Investigational Site
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Kyiv, Ukraine, 4107
- GSK Investigational Site
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Lutsk, Ukraine, 43024
- GSK Investigational Site
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Lviv, Ukraine, 79010
- GSK Investigational Site
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Lviv, Ukraine, 79015
- GSK Investigational Site
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Mykolaiv, Ukraine, 54003
- GSK Investigational Site
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Odesa, Ukraine, 65010
- GSK Investigational Site
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Odesa, Ukraine, 65114
- GSK Investigational Site
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Odessa, Ukraine, 65025
- GSK Investigational Site
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Odessa, Ukraine, 65009
- GSK Investigational Site
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Poltava, Ukraine, 36024
- GSK Investigational Site
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Poltava, Ukraine, 36028
- GSK Investigational Site
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Poltava, Ukraine, 36038
- GSK Investigational Site
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Simferopol, Ukraine, 95043
- GSK Investigational Site
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Sumy, Ukraine, 40022
- GSK Investigational Site
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Sumy, Ukraine, 40030
- GSK Investigational Site
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Sympheropol, Ukraine, 95017
- GSK Investigational Site
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Ternopil, Ukraine, 46002
- GSK Investigational Site
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Uzhhorod, Ukraine, 88000
- GSK Investigational Site
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Uzhhorod, Ukraine, 88009
- GSK Investigational Site
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Uzhhorod, Ukraine, 88017
- GSK Investigational Site
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Vinnytsia, Ukraine, 21018
- GSK Investigational Site
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Vinnytsia, Ukraine, 21029
- GSK Investigational Site
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Vinnytsya, Ukraine, 21001
- GSK Investigational Site
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Yalta, Ukraine, 98603
- GSK Investigational Site
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Zaporizhia, Ukraine, 69035
- GSK Investigational Site
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Zaporizhzhia, Ukraine, 69600
- GSK Investigational Site
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Zaporizhzhia, Ukraine, 69106
- GSK Investigational Site
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Zaporizhzhia, Ukraine, 69118
- GSK Investigational Site
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Zaporizhzhya, Ukraine, 69001
- GSK Investigational Site
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Zhytomyr, Ukraine, 10002
- GSK Investigational Site
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-
-
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Bexhill-on-Sea, United Kingdom, TN40 1JJ
- GSK Investigational Site
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Birmingham, United Kingdom, B9 5SS
- GSK Investigational Site
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Brighton, United Kingdom, BN2 5BE
- GSK Investigational Site
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Cardiff, United Kingdom, CF14 5GJ
- GSK Investigational Site
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Chelmsford, United Kingdom, CM1 7ET
- GSK Investigational Site
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Derby, United Kingdom, DE22 3NE
- GSK Investigational Site
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Edgbaston, Birmingham, United Kingdom, B15 2SQ
- GSK Investigational Site
-
Edinburgh, United Kingdom, EH16 4SA
- GSK Investigational Site
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Glasgow, United Kingdom, G20 0SP
- GSK Investigational Site
-
London, United Kingdom, EC1M 6BQ
- GSK Investigational Site
-
Manchester, United Kingdom, M15 6SX
- GSK Investigational Site
-
Milton Keynes, United Kingdom, MK6 5LD
- GSK Investigational Site
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Reading, United Kingdom, RG2 0TG
- GSK Investigational Site
-
Sidcup, Kent, United Kingdom, DA14 6LT
- GSK Investigational Site
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Tyne And Wear, United Kingdom, NE29 8NH
- GSK Investigational Site
-
-
Bedfordshire
-
Bedford, Bedfordshire, United Kingdom, MK42 9DJ
- GSK Investigational Site
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Bedford, Bedfordshire, United Kingdom, MK404AW
- GSK Investigational Site
-
-
Cambridgeshire
-
Peterborough, Cambridgeshire, United Kingdom, PE8 6PL
- GSK Investigational Site
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Soham, Cambridgeshire, United Kingdom, CB7 5JD
- GSK Investigational Site
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-
Derbyshire
-
Chesterfield, Derbyshire, United Kingdom, S40 4AA
- GSK Investigational Site
-
-
Lancashire
-
Buckshaw Village, Chorley, Lancashire, United Kingdom, PR7 7NA
- GSK Investigational Site
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-
Merseyside
-
Liverpool, Merseyside, United Kingdom, L9 7AL
- GSK Investigational Site
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Waterloo, Liverpool, Merseyside, United Kingdom, L22 0LG
- GSK Investigational Site
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-
Middlesex
-
Northwood, Middlesex, United Kingdom, HA6 2RN
- GSK Investigational Site
-
-
Suffolk
-
Bury St Edmunds, Suffolk, United Kingdom, IP30 9QU
- GSK Investigational Site
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-
-
-
Alabama
-
Andalusia, Alabama, United States, 36420
- GSK Investigational Site
-
Athens, Alabama, United States, 35611
- GSK Investigational Site
-
Birmingham, Alabama, United States, 35209
- GSK Investigational Site
-
Birmingham, Alabama, United States, 35233
- GSK Investigational Site
-
Birmingham, Alabama, United States, 35216
- GSK Investigational Site
-
Birmingham, Alabama, United States, 35242
- GSK Investigational Site
-
Huntsville, Alabama, United States, 35801
- GSK Investigational Site
-
Huntsville, Alabama, United States, 35816
- GSK Investigational Site
-
Mobile, Alabama, United States, 36608
- GSK Investigational Site
-
Mobile, Alabama, United States, 36604
- GSK Investigational Site
-
Montgomery, Alabama, United States, 36106
- GSK Investigational Site
-
Montgomery, Alabama, United States, 36109
- GSK Investigational Site
-
Muscle Shoals, Alabama, United States, 35662
- GSK Investigational Site
-
Ozark, Alabama, United States, 36360
- GSK Investigational Site
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Pell City, Alabama, United States, 35128
- GSK Investigational Site
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Tuscumbia, Alabama, United States, 35674
- GSK Investigational Site
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-
Arizona
-
Flagstaff, Arizona, United States, 86001
- GSK Investigational Site
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Glendale, Arizona, United States, 85306
- GSK Investigational Site
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Phoenix, Arizona, United States, 85018
- GSK Investigational Site
-
Phoenix, Arizona, United States, 85032
- GSK Investigational Site
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Scottsdale, Arizona, United States, 85258
- GSK Investigational Site
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Sierra Vista, Arizona, United States, 85635
- GSK Investigational Site
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Tucson, Arizona, United States, 85745
- GSK Investigational Site
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Tucson, Arizona, United States, 85710
- GSK Investigational Site
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-
Arkansas
-
Fayetteville, Arkansas, United States, 72703
- GSK Investigational Site
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Jonesboro, Arkansas, United States, 72401
- GSK Investigational Site
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-
California
-
Anaheim, California, United States, 92801
- GSK Investigational Site
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Bakersfield, California, United States, 93301
- GSK Investigational Site
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Cerritos, California, United States, 90703
- GSK Investigational Site
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Encinitas, California, United States, 92024
- GSK Investigational Site
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Foothill Ranch, California, United States, 92610
- GSK Investigational Site
-
Fountain Valley, California, United States, 92708
- GSK Investigational Site
-
Garden Grove, California, United States, 92844
- GSK Investigational Site
-
Gold River, California, United States, 95670
- GSK Investigational Site
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Huntington Beach, California, United States, 92647
- GSK Investigational Site
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Huntington Park, California, United States, 90255
- GSK Investigational Site
-
Lakewood, California, United States, 90712
- GSK Investigational Site
-
Lancaster, California, United States, 93534
- GSK Investigational Site
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Loma Linda, California, United States, 92357
- GSK Investigational Site
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Long Beach, California, United States, 90822
- GSK Investigational Site
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Los Angeles, California, United States, 90095
- GSK Investigational Site
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Los Angeles, California, United States, 90048
- GSK Investigational Site
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Los Angeles, California, United States, 90033
- GSK Investigational Site
-
Los Angeles, California, United States, 90036
- GSK Investigational Site
-
Mission Hills, California, United States, 91345
- GSK Investigational Site
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Mission Viejo, California, United States, 92691
- GSK Investigational Site
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Modesto, California, United States, 95350
- GSK Investigational Site
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Montclair, California, United States, 91763
- GSK Investigational Site
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Monterey Park, California, United States, 91754
- GSK Investigational Site
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Oxnard, California, United States, 93030-5841
- GSK Investigational Site
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Palo Alto, California, United States, 94304
- GSK Investigational Site
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Pasadena, California, United States, 91105
- GSK Investigational Site
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Pismo Beach, California, United States, 93449
- GSK Investigational Site
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Rancho Mirage, California, United States, 92270
- GSK Investigational Site
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Riverside, California, United States, 92506
- GSK Investigational Site
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Rolling Hills Estates, California, United States, 90274
- GSK Investigational Site
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Sacramento, California, United States, 95821
- GSK Investigational Site
-
Sacramento, California, United States, 95816
- GSK Investigational Site
-
Sacramento, California, United States, 95817
- GSK Investigational Site
-
Sacramento, California, United States, 95819
- GSK Investigational Site
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San Diego, California, United States, 92103
- GSK Investigational Site
-
San Diego, California, United States, 92120
- GSK Investigational Site
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San Diego, California, United States, 92117
- GSK Investigational Site
-
San Diego, California, United States, 92108
- GSK Investigational Site
-
San Diego, California, United States, 92111
- GSK Investigational Site
-
San Diego, California, United States, 91910
- GSK Investigational Site
-
San Gabriel, California, United States, 91776
- GSK Investigational Site
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San Jose, California, United States, 95116
- GSK Investigational Site
-
San Marino, California, United States, 91108
- GSK Investigational Site
-
Santa Monica, California, United States, 90404
- GSK Investigational Site
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Sepulveda, California, United States, 91343
- GSK Investigational Site
-
Simi Valley, California, United States, 93065
- GSK Investigational Site
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Stockton, California, United States, 95207
- GSK Investigational Site
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Torrance, California, United States, 90502
- GSK Investigational Site
-
Torrance, California, United States, 90505
- GSK Investigational Site
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Van Nuys, California, United States, 91405
- GSK Investigational Site
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Ventura, California, United States, 93003
- GSK Investigational Site
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West Covina, California, United States, 91790
- GSK Investigational Site
-
-
Colorado
-
Centennial, Colorado, United States, 80112
- GSK Investigational Site
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Colorado Springs, Colorado, United States, 80907
- GSK Investigational Site
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Colorado Springs, Colorado, United States, 80910
- GSK Investigational Site
-
Denver, Colorado, United States, 80206
- GSK Investigational Site
-
Fort Collins, Colorado, United States, 80528
- GSK Investigational Site
-
Fort Collins, Colorado, United States, 80538
- GSK Investigational Site
-
Wheat Ridge, Colorado, United States, 80033
- GSK Investigational Site
-
-
Connecticut
-
Danbury, Connecticut, United States, 06810
- GSK Investigational Site
-
Hartford, Connecticut, United States, 06105
- GSK Investigational Site
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Waterbury, Connecticut, United States, 06708
- GSK Investigational Site
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-
District of Columbia
-
Washington, District of Columbia, United States, 20422
- GSK Investigational Site
-
-
Florida
-
Altamonte Springs, Florida, United States, 32714
- GSK Investigational Site
-
Aventura, Florida, United States, 33180
- GSK Investigational Site
-
Bay Pines, Florida, United States, 33744
- GSK Investigational Site
-
Boynton Beach, Florida, United States, 33435
- GSK Investigational Site
-
Boynton Beach, Florida, United States, 33472
- GSK Investigational Site
-
Brandon, Florida, United States, 33511
- GSK Investigational Site
-
Celebration, Florida, United States, 34747
- GSK Investigational Site
-
Clearwater, Florida, United States, 33756
- GSK Investigational Site
-
Clearwater, Florida, United States, 33765-2616
- GSK Investigational Site
-
Clearwater, Florida, United States, 33765
- GSK Investigational Site
-
Clearwater, Florida, United States, 33755
- GSK Investigational Site
-
Clearwater, Florida, United States, 33759
- GSK Investigational Site
-
Crystal River, Florida, United States, 34429
- GSK Investigational Site
-
Daytona Beach, Florida, United States, 32117
- GSK Investigational Site
-
DeBary, Florida, United States, 32173
- GSK Investigational Site
-
DeLand, Florida, United States, 32720
- GSK Investigational Site
-
Edgewater, Florida, United States, 32132
- GSK Investigational Site
-
Fleming Island, Florida, United States, 32003
- GSK Investigational Site
-
Fort Lauderdale, Florida, United States, 33316
- GSK Investigational Site
-
Gainesville, Florida, United States, 32608
- GSK Investigational Site
-
Hialeah, Florida, United States, 33012
- GSK Investigational Site
-
Hialeah, Florida, United States, 33013
- GSK Investigational Site
-
Hialeah, Florida, United States, 33016
- GSK Investigational Site
-
Hollywood, Florida, United States, 33021
- GSK Investigational Site
-
Jacksonville, Florida, United States, 32216
- GSK Investigational Site
-
Jacksonville, Florida, United States, 32209
- GSK Investigational Site
-
Kissimmee, Florida, United States, 34741
- GSK Investigational Site
-
Leesburg, Florida, United States, 34748
- GSK Investigational Site
-
Lehigh Acres, Florida, United States, 33971
- GSK Investigational Site
-
Maitland, Florida, United States, 32751
- GSK Investigational Site
-
Melbourne, Florida, United States, 32934
- GSK Investigational Site
-
Miami, Florida, United States, 33125
- GSK Investigational Site
-
Miami, Florida, United States, 33126
- GSK Investigational Site
-
Miami, Florida, United States, 33135
- GSK Investigational Site
-
Miami, Florida, United States, 33142
- GSK Investigational Site
-
Miami, Florida, United States, 33175
- GSK Investigational Site
-
Miami, Florida, United States, 33144
- GSK Investigational Site
-
Miami, Florida, United States, 33165
- GSK Investigational Site
-
Miami, Florida, United States, 33174
- GSK Investigational Site
-
Miami, Florida, United States, 33186
- GSK Investigational Site
-
Miami, Florida, United States, 33155
- GSK Investigational Site
-
Miami, Florida, United States, 33185
- GSK Investigational Site
-
Miami, Florida, United States, 33015
- GSK Investigational Site
-
Miami, Florida, United States, 33133
- GSK Investigational Site
-
Miami Gardens, Florida, United States, 33169
- GSK Investigational Site
-
New Port Richey, Florida, United States, 34652
- GSK Investigational Site
-
North Miami Beach, Florida, United States, 33179
- GSK Investigational Site
-
Oakland Park, Florida, United States, 33309
- GSK Investigational Site
-
Ocala, Florida, United States, 34471
- GSK Investigational Site
-
Orlando, Florida, United States, 32803
- GSK Investigational Site
-
Orlando, Florida, United States, 32825
- GSK Investigational Site
-
Orlando, Florida, United States, 32811
- GSK Investigational Site
-
Palm Harbor, Florida, United States, 34684
- GSK Investigational Site
-
Pembroke Pines, Florida, United States, 33027
- GSK Investigational Site
-
Pensacola, Florida, United States, 32503
- GSK Investigational Site
-
Pensacola, Florida, United States, 32514
- GSK Investigational Site
-
Pinellas Park, Florida, United States, 33781
- GSK Investigational Site
-
Port Charlotte, Florida, United States, 33952
- GSK Investigational Site
-
Port Orange, Florida, United States, 32129
- GSK Investigational Site
-
Saint Petersburg, Florida, United States, 33713
- GSK Investigational Site
-
Saint Petersburg, Florida, United States, 33709
- GSK Investigational Site
-
Saint Petersburg, Florida, United States, 33707
- GSK Investigational Site
-
Saint Petersburg, Florida, United States, 33704
- GSK Investigational Site
-
Sarasota, Florida, United States, 34239
- GSK Investigational Site
-
South Miami, Florida, United States, 33143
- GSK Investigational Site
-
Summerfield, Florida, United States, 34491
- GSK Investigational Site
-
Tamarac, Florida, United States, 33319
- GSK Investigational Site
-
Tampa, Florida, United States, 33613
- GSK Investigational Site
-
Tampa, Florida, United States, 33603
- GSK Investigational Site
-
Tampa, Florida, United States, 33607
- GSK Investigational Site
-
Trinity, Florida, United States, 34655
- GSK Investigational Site
-
Vero Beach, Florida, United States, 32960
- GSK Investigational Site
-
Vero Beach, Florida, United States, 32958
- GSK Investigational Site
-
Wellington, Florida, United States, 33414
- GSK Investigational Site
-
Winter Park, Florida, United States, 32789
- GSK Investigational Site
-
Zephyrhills, Florida, United States, 33540
- GSK Investigational Site
-
-
Georgia
-
Atlanta, Georgia, United States, 30342
- GSK Investigational Site
-
Austell, Georgia, United States, 30106
- GSK Investigational Site
-
Blue Ridge, Georgia, United States, 30513
- GSK Investigational Site
-
Calhoun, Georgia, United States, 30701
- GSK Investigational Site
-
Canton, Georgia, United States, 30114
- GSK Investigational Site
-
Columbus, Georgia, United States, 31904
- GSK Investigational Site
-
Cumming, Georgia, United States, 30041
- GSK Investigational Site
-
Decatur, Georgia, United States, 30033
- GSK Investigational Site
-
Gainesville, Georgia, United States, 30501
- GSK Investigational Site
-
Lawrenceville, Georgia, United States, 30046
- GSK Investigational Site
-
Marietta, Georgia, United States, 30060
- GSK Investigational Site
-
Rincon, Georgia, United States, 31326
- GSK Investigational Site
-
Suwanee, Georgia, United States, 30024
- GSK Investigational Site
-
Woodstock, Georgia, United States, 30189
- GSK Investigational Site
-
-
Hawaii
-
Honolulu, Hawaii, United States, 96813
- GSK Investigational Site
-
-
Idaho
-
Boise, Idaho, United States, 83642
- GSK Investigational Site
-
Coeur d'Alene, Idaho, United States, 90212
- GSK Investigational Site
-
Hayden Lake, Idaho, United States, 83835
- GSK Investigational Site
-
Idaho Falls, Idaho, United States, 83402
- GSK Investigational Site
-
Nampa, Idaho, United States, 83687
- GSK Investigational Site
-
-
Illinois
-
Aurora, Illinois, United States, 60504
- GSK Investigational Site
-
Champaign, Illinois, United States, 61820
- GSK Investigational Site
-
Chicago, Illinois, United States, 60612
- GSK Investigational Site
-
Chicago, Illinois, United States, 60603
- GSK Investigational Site
-
Evergreen Park, Illinois, United States, 60805
- GSK Investigational Site
-
Gillespie, Illinois, United States, 62033
- GSK Investigational Site
-
Melrose Park, Illinois, United States, 60160
- GSK Investigational Site
-
North Chicago, Illinois, United States, 60064
- GSK Investigational Site
-
Oak Lawn, Illinois, United States, 60453
- GSK Investigational Site
-
Peoria, Illinois, United States, 61602
- GSK Investigational Site
-
Quincy, Illinois, United States, 62301
- GSK Investigational Site
-
River Forest, Illinois, United States, 60305
- GSK Investigational Site
-
Skokie, Illinois, United States, 60076
- GSK Investigational Site
-
-
Indiana
-
Avon, Indiana, United States, 46123
- GSK Investigational Site
-
Elwood, Indiana, United States, 46036
- GSK Investigational Site
-
Evansville, Indiana, United States, 47714
- GSK Investigational Site
-
Franklin, Indiana, United States, 46131
- GSK Investigational Site
-
Greenfield, Indiana, United States, 46140
- GSK Investigational Site
-
Muncie, Indiana, United States, 47304-5547
- GSK Investigational Site
-
Valparaiso, Indiana, United States, 46383
- GSK Investigational Site
-
-
Iowa
-
Council Bluffs, Iowa, United States, 51503
- GSK Investigational Site
-
Dubuque, Iowa, United States, 52001
- GSK Investigational Site
-
Iowa City, Iowa, United States, 52242
- GSK Investigational Site
-
West Des Moines, Iowa, United States, 50265
- GSK Investigational Site
-
-
Kansas
-
Newton, Kansas, United States, 67114
- GSK Investigational Site
-
Olathe, Kansas, United States, 66061
- GSK Investigational Site
-
Topeka, Kansas, United States, 66606
- GSK Investigational Site
-
Topeka, Kansas, United States, 66615
- GSK Investigational Site
-
Wichita, Kansas, United States, 67218
- GSK Investigational Site
-
-
Kentucky
-
Bowling Green, Kentucky, United States, 42101
- GSK Investigational Site
-
Crestview Hills, Kentucky, United States, 41017
- GSK Investigational Site
-
Hawesville, Kentucky, United States, 42348
- GSK Investigational Site
-
Hazard, Kentucky, United States, 41701
- GSK Investigational Site
-
Lexington, Kentucky, United States, 40504
- GSK Investigational Site
-
Louisville, Kentucky, United States, 40202
- GSK Investigational Site
-
Owensboro, Kentucky, United States, 42303-3163
- GSK Investigational Site
-
-
Louisiana
-
Lafayette, Louisiana, United States, 70508
- GSK Investigational Site
-
Metairie, Louisiana, United States, 70006
- GSK Investigational Site
-
Opelousas, Louisiana, United States, 70570
- GSK Investigational Site
-
-
Maine
-
Auburn, Maine, United States, 04210
- GSK Investigational Site
-
Bangor, Maine, United States, 04401
- GSK Investigational Site
-
Biddeford, Maine, United States, 04005
- GSK Investigational Site
-
-
Maryland
-
Baltimore, Maryland, United States, 21224
- GSK Investigational Site
-
Baltimore, Maryland, United States, 21201
- GSK Investigational Site
-
Baltimore, Maryland, United States, 21239
- GSK Investigational Site
-
Columbia, Maryland, United States, 21044
- GSK Investigational Site
-
Elkton, Maryland, United States, 21921
- GSK Investigational Site
-
Hagerstown, Maryland, United States, 21740
- GSK Investigational Site
-
Hollywood, Maryland, United States, 20636
- GSK Investigational Site
-
Lutherville, Maryland, United States, 21093
- GSK Investigational Site
-
Oxon Hill, Maryland, United States, 20745
- GSK Investigational Site
-
Towson, Maryland, United States, 21204
- GSK Investigational Site
-
-
Massachusetts
-
Brockton, Massachusetts, United States, 02301
- GSK Investigational Site
-
Fall River, Massachusetts, United States, 02720
- GSK Investigational Site
-
North Dartmouth, Massachusetts, United States, 02747
- GSK Investigational Site
-
-
Michigan
-
Ann Arbor, Michigan, United States, 48106
- GSK Investigational Site
-
Buckley, Michigan, United States, 49620
- GSK Investigational Site
-
Cadillac, Michigan, United States, 49601
- GSK Investigational Site
-
Detroit, Michigan, United States, 48235
- GSK Investigational Site
-
Detroit, Michigan, United States, 48201
- GSK Investigational Site
-
Detroit, Michigan, United States, 48221
- GSK Investigational Site
-
Grand Blanc, Michigan, United States, 48439
- GSK Investigational Site
-
Kalamazoo, Michigan, United States, 49009
- GSK Investigational Site
-
Niles, Michigan, United States, 49120
- GSK Investigational Site
-
Rochester, Michigan, United States, 48307
- GSK Investigational Site
-
Royal Oak, Michigan, United States, 48073-6769
- GSK Investigational Site
-
Traverse City, Michigan, United States, 49684
- GSK Investigational Site
-
Troy, Michigan, United States, 48098
- GSK Investigational Site
-
Troy, Michigan, United States, 48085
- GSK Investigational Site
-
-
Minnesota
-
Coon Rapids, Minnesota, United States, 55433
- GSK Investigational Site
-
Edina, Minnesota, United States, 55435
- GSK Investigational Site
-
Fridley, Minnesota, United States, 55432
- GSK Investigational Site
-
Minneapolis, Minnesota, United States, 55407
- GSK Investigational Site
-
Minneapolis, Minnesota, United States, 55402
- GSK Investigational Site
-
Minneapolis, Minnesota, United States, 55417
- GSK Investigational Site
-
Plymouth, Minnesota, United States, 55441
- GSK Investigational Site
-
Rochester, Minnesota, United States, 55905
- GSK Investigational Site
-
Saint Paul, Minnesota, United States, 55130
- GSK Investigational Site
-
Woodbury, Minnesota, United States, 55125
- GSK Investigational Site
-
-
Missouri
-
Chesterfield, Missouri, United States, 63017
- GSK Investigational Site
-
Kansas City, Missouri, United States, 64128
- GSK Investigational Site
-
Kansas City, Missouri, United States, 64106
- GSK Investigational Site
-
Saint Louis, Missouri, United States, 63141
- GSK Investigational Site
-
Saint Louis, Missouri, United States, 63143
- GSK Investigational Site
-
Saint Louis, Missouri, United States, 63117
- GSK Investigational Site
-
-
Montana
-
Billings, Montana, United States, 59102
- GSK Investigational Site
-
Billings, Montana, United States, 59101
- GSK Investigational Site
-
Butte, Montana, United States, 59701
- GSK Investigational Site
-
Great Falls, Montana, United States, 59405
- GSK Investigational Site
-
Missoula, Montana, United States, 59808
- GSK Investigational Site
-
-
Nebraska
-
Bellevue, Nebraska, United States, 68123-4303
- GSK Investigational Site
-
Fremont, Nebraska, United States, 68025
- GSK Investigational Site
-
Grand Island, Nebraska, United States, 68803
- GSK Investigational Site
-
Lincoln, Nebraska, United States, 68516
- GSK Investigational Site
-
Lincoln, Nebraska, United States, 68506
- GSK Investigational Site
-
Lincoln, Nebraska, United States, 02865
- GSK Investigational Site
-
Lincoln, Nebraska, United States, 68512
- GSK Investigational Site
-
Omaha, Nebraska, United States, 68198
- GSK Investigational Site
-
Omaha, Nebraska, United States, 68114
- GSK Investigational Site
-
Omaha, Nebraska, United States, 68134
- GSK Investigational Site
-
-
Nevada
-
Henderson, Nevada, United States, 89014
- GSK Investigational Site
-
Las Vegas, Nevada, United States, 89119
- GSK Investigational Site
-
Las Vegas, Nevada, United States, 89106
- GSK Investigational Site
-
Reno, Nevada, United States, 89502
- GSK Investigational Site
-
-
New Jersey
-
Brick, New Jersey, United States, 08723
- GSK Investigational Site
-
Edison, New Jersey, United States, 8820
- GSK Investigational Site
-
Elizabeth, New Jersey, United States, 07202
- GSK Investigational Site
-
Elizabeth, New Jersey, United States, 07201
- GSK Investigational Site
-
Freehold, New Jersey, United States, 07728
- GSK Investigational Site
-
Linden, New Jersey, United States, 07036
- GSK Investigational Site
-
Lodi, New Jersey, United States, 07644
- GSK Investigational Site
-
Margate City, New Jersey, United States, 08402
- GSK Investigational Site
-
Princeton, New Jersey, United States, 08540
- GSK Investigational Site
-
Salem, New Jersey, United States, 08079
- GSK Investigational Site
-
Verona, New Jersey, United States, 07044
- GSK Investigational Site
-
-
New Mexico
-
Albuquerque, New Mexico, United States, 87108
- GSK Investigational Site
-
-
New York
-
Albany, New York, United States, 12208
- GSK Investigational Site
-
Bronx, New York, United States, 10461
- GSK Investigational Site
-
Bronx, New York, United States, 10457
- GSK Investigational Site
-
Bronxville, New York, United States, 10708
- GSK Investigational Site
-
Brooklyn, New York, United States, 11229
- GSK Investigational Site
-
Brooklyn, New York, United States, 11215
- GSK Investigational Site
-
Buffalo, New York, United States, 14215-1199
- GSK Investigational Site
-
Corning, New York, United States, 14830
- GSK Investigational Site
-
Great Neck, New York, United States, 11023
- GSK Investigational Site
-
Manhattan, New York, United States, 10029
- GSK Investigational Site
-
Massapequa, New York, United States, 11758
- GSK Investigational Site
-
New York, New York, United States, 10021
- GSK Investigational Site
-
New York, New York, United States, 10016
- GSK Investigational Site
-
New York, New York, United States, 10001
- GSK Investigational Site
-
New York, New York, United States, 10038
- GSK Investigational Site
-
New York, New York, United States, 10004
- GSK Investigational Site
-
New York, New York, United States, 10009
- GSK Investigational Site
-
New York, New York, United States, 10028
- GSK Investigational Site
-
New York, New York, United States, 10019
- GSK Investigational Site
-
Rochester, New York, United States, 14618
- GSK Investigational Site
-
Syracuse, New York, United States, 13210
- GSK Investigational Site
-
Westfield, New York, United States, 14787
- GSK Investigational Site
-
-
North Carolina
-
Asheville, North Carolina, United States, 28801
- GSK Investigational Site
-
Calabash, North Carolina, United States, 28467
- GSK Investigational Site
-
Charlotte, North Carolina, United States, 28209
- GSK Investigational Site
-
Charlotte, North Carolina, United States, 28210
- GSK Investigational Site
-
Elizabeth City, North Carolina, United States, 27909
- GSK Investigational Site
-
Greensboro, North Carolina, United States, 27405
- GSK Investigational Site
-
Greensboro, North Carolina, United States, 27403
- GSK Investigational Site
-
Greensboro, North Carolina, United States, 27401
- GSK Investigational Site
-
Greensboro, North Carolina, United States, 27408
- GSK Investigational Site
-
Greenville, North Carolina, United States, 27858
- GSK Investigational Site
-
High Point, North Carolina, United States, 27262
- GSK Investigational Site
-
Huntersville, North Carolina, United States, 28078
- GSK Investigational Site
-
Knightdale, North Carolina, United States, 27545
- GSK Investigational Site
-
Lexington, North Carolina, United States, 27295
- GSK Investigational Site
-
Morganton, North Carolina, United States, 28655
- GSK Investigational Site
-
Salisbury, North Carolina, United States, 28144
- GSK Investigational Site
-
Shelby, North Carolina, United States, 28152
- GSK Investigational Site
-
Smithfield, North Carolina, United States, 27577
- GSK Investigational Site
-
Statesville, North Carolina, United States, 28625
- GSK Investigational Site
-
Wilmington, North Carolina, United States, 28401
- GSK Investigational Site
-
Winston-Salem, North Carolina, United States, 27103
- GSK Investigational Site
-
-
Ohio
-
Akron, Ohio, United States, 44313
- GSK Investigational Site
-
Chardon, Ohio, United States, 44024
- GSK Investigational Site
-
Cincinnati, Ohio, United States, 45231
- GSK Investigational Site
-
Cincinnati, Ohio, United States, 45242
- GSK Investigational Site
-
Cincinnati, Ohio, United States, 45220
- GSK Investigational Site
-
Cleveland, Ohio, United States, 44106
- GSK Investigational Site
-
Cleveland, Ohio, United States, 44122
- GSK Investigational Site
-
Cleveland, Ohio, United States, 44109
- GSK Investigational Site
-
Columbus, Ohio, United States, 43215
- GSK Investigational Site
-
Columbus, Ohio, United States, 43213
- GSK Investigational Site
-
Columbus, Ohio, United States, 43214
- GSK Investigational Site
-
Columbus, Ohio, United States, 43235
- GSK Investigational Site
-
Dayton, Ohio, United States, 45406
- GSK Investigational Site
-
Dayton, Ohio, United States, 45459
- GSK Investigational Site
-
Kettering, Ohio, United States, 45429
- GSK Investigational Site
-
Marion, Ohio, United States, 43302
- GSK Investigational Site
-
Maumee, Ohio, United States, 43537-9402
- GSK Investigational Site
-
Miamisburg, Ohio, United States, 45342
- GSK Investigational Site
-
Toledo, Ohio, United States, 43606
- GSK Investigational Site
-
Toledo, Ohio, United States, 43614-5809
- GSK Investigational Site
-
Toledo, Ohio, United States, 43617
- GSK Investigational Site
-
Wooster, Ohio, United States, 44691
- GSK Investigational Site
-
Youngstown, Ohio, United States, 44501
- GSK Investigational Site
-
-
Oklahoma
-
Oklahoma City, Oklahoma, United States, 73103
- GSK Investigational Site
-
Tulsa, Oklahoma, United States, 74136
- GSK Investigational Site
-
Tulsa, Oklahoma, United States, 74127
- GSK Investigational Site
-
-
Oregon
-
Bend, Oregon, United States, 97701
- GSK Investigational Site
-
Portland, Oregon, United States, 97202
- GSK Investigational Site
-
Portland, Oregon, United States, 97219
- GSK Investigational Site
-
Springfield, Oregon, United States, 97477
- GSK Investigational Site
-
-
Pennsylvania
-
Beaver, Pennsylvania, United States, 15009
- GSK Investigational Site
-
Belle Vernon, Pennsylvania, United States, 15012
- GSK Investigational Site
-
Bensalem, Pennsylvania, United States, 19020
- GSK Investigational Site
-
Clairton, Pennsylvania, United States, 15025
- GSK Investigational Site
-
Downingtown, Pennsylvania, United States, 19335
- GSK Investigational Site
-
Doylestown, Pennsylvania, United States, 18901
- GSK Investigational Site
-
Erie, Pennsylvania, United States, 16508
- GSK Investigational Site
-
Fleetwood, Pennsylvania, United States, 19522
- GSK Investigational Site
-
Harleysville, Pennsylvania, United States, 19438
- GSK Investigational Site
-
Jersey Shore, Pennsylvania, United States, 17740
- GSK Investigational Site
-
Langhorne, Pennsylvania, United States, 19047
- GSK Investigational Site
-
Lansdale, Pennsylvania, United States, 19446
- GSK Investigational Site
-
Monroeville, Pennsylvania, United States, 15146
- GSK Investigational Site
-
Philadelphia, Pennsylvania, United States, 19107
- GSK Investigational Site
-
Philadelphia, Pennsylvania, United States, 19140
- GSK Investigational Site
-
Philadelphia, Pennsylvania, United States, 19152
- GSK Investigational Site
-
Philadelphia, Pennsylvania, United States, 19142
- GSK Investigational Site
-
Phoenixville, Pennsylvania, United States, 19460
- GSK Investigational Site
-
Pittsburgh, Pennsylvania, United States, 15236
- GSK Investigational Site
-
Pittsburgh, Pennsylvania, United States, 15213
- GSK Investigational Site
-
Pittsburgh, Pennsylvania, United States, 15243
- GSK Investigational Site
-
Scottdale, Pennsylvania, United States, 15683
- GSK Investigational Site
-
Scranton, Pennsylvania, United States, 18501
- GSK Investigational Site
-
Uniontown, Pennsylvania, United States, 15401
- GSK Investigational Site
-
Warminster, Pennsylvania, United States, 18974
- GSK Investigational Site
-
-
Rhode Island
-
Cumberland, Rhode Island, United States, 02864
- GSK Investigational Site
-
East Providence, Rhode Island, United States, 02914
- GSK Investigational Site
-
Johnston, Rhode Island, United States, 02919
- GSK Investigational Site
-
-
South Carolina
-
Anderson, South Carolina, United States, 29621
- GSK Investigational Site
-
Charleston, South Carolina, United States, 29407
- GSK Investigational Site
-
Charleston, South Carolina, United States, 29406-7108
- GSK Investigational Site
-
Columbia, South Carolina, United States, 29201
- GSK Investigational Site
-
Columbia, South Carolina, United States, 29209
- GSK Investigational Site
-
Easley, South Carolina, United States, 29640
- GSK Investigational Site
-
Florence, South Carolina, United States, 29501
- GSK Investigational Site
-
Gaffney, South Carolina, United States, 29340
- GSK Investigational Site
-
Greenville, South Carolina, United States, 29615
- GSK Investigational Site
-
Greenwood, South Carolina, United States, 29646
- GSK Investigational Site
-
Greer, South Carolina, United States, 29651
- GSK Investigational Site
-
Greer, South Carolina, United States, 29650
- GSK Investigational Site
-
Indian Land, South Carolina, United States, 29707
- GSK Investigational Site
-
Murrells Inlet, South Carolina, United States, 29576
- GSK Investigational Site
-
Pelzer, South Carolina, United States, 29669
- GSK Investigational Site
-
Rock Hill, South Carolina, United States, 29732
- GSK Investigational Site
-
Spartanburg, South Carolina, United States, 29303
- GSK Investigational Site
-
Williamston, South Carolina, United States, 29697
- GSK Investigational Site
-
-
South Dakota
-
Dakota Dunes, South Dakota, United States, 57049
- GSK Investigational Site
-
Rapid City, South Dakota, United States, 57702
- GSK Investigational Site
-
-
Tennessee
-
Chattanooga, Tennessee, United States, 37404
- GSK Investigational Site
-
Fayetteville, Tennessee, United States, 37334
- GSK Investigational Site
-
Franklin, Tennessee, United States, 27064
- GSK Investigational Site
-
Nashville, Tennessee, United States, 37215
- GSK Investigational Site
-
Shelbyville, Tennessee, United States, 37160
- GSK Investigational Site
-
-
Texas
-
Amarillo, Texas, United States, 79124
- GSK Investigational Site
-
Austin, Texas, United States, 78758
- GSK Investigational Site
-
Austin, Texas, United States, 78756
- GSK Investigational Site
-
Boerne, Texas, United States, 78006
- GSK Investigational Site
-
Corpus Christi, Texas, United States, 78405
- GSK Investigational Site
-
Corsicana, Texas, United States, 75110
- GSK Investigational Site
-
Dallas, Texas, United States, 75246
- GSK Investigational Site
-
Dallas, Texas, United States, 75216
- GSK Investigational Site
-
Dallas, Texas, United States, 75225
- GSK Investigational Site
-
Dallas, Texas, United States, 75254
- GSK Investigational Site
-
Duncanville, Texas, United States, 75116
- GSK Investigational Site
-
Edinburg, Texas, United States, 78539
- GSK Investigational Site
-
Fort Worth, Texas, United States, 76104
- GSK Investigational Site
-
Frisco, Texas, United States, 75034
- GSK Investigational Site
-
Frisco, Texas, United States, 75035
- GSK Investigational Site
-
Galveston, Texas, United States, 77555
- GSK Investigational Site
-
Georgetown, Texas, United States, 78626
- GSK Investigational Site
-
Houston, Texas, United States, 77030
- GSK Investigational Site
-
Houston, Texas, United States, 77074
- GSK Investigational Site
-
Houston, Texas, United States, 77081
- GSK Investigational Site
-
Houston, Texas, United States, 77099
- GSK Investigational Site
-
Houston, Texas, United States, 77024
- GSK Investigational Site
-
Houston, Texas, United States, 77034
- GSK Investigational Site
-
Houston, Texas, United States, 77025
- GSK Investigational Site
-
Houston, Texas, United States, 77043
- GSK Investigational Site
-
Houston, Texas, United States, 77029
- GSK Investigational Site
-
Houston, Texas, United States, 77062
- GSK Investigational Site
-
Houston, Texas, United States, 77077
- GSK Investigational Site
-
Houston, Texas, United States, 77079
- GSK Investigational Site
-
Huntsville, Texas, United States, 77340
- GSK Investigational Site
-
Irving, Texas, United States, 75039
- GSK Investigational Site
-
Killeen, Texas, United States, 76543
- GSK Investigational Site
-
Kingwood, Texas, United States, 77339
- GSK Investigational Site
-
Lewisville, Texas, United States, 75067
- GSK Investigational Site
-
Longview, Texas, United States, 75605
- GSK Investigational Site
-
Lufkin, Texas, United States, 75904
- GSK Investigational Site
-
McKinney, Texas, United States, 75069
- GSK Investigational Site
-
McKinney, Texas, United States, 75071
- GSK Investigational Site
-
Plano, Texas, United States, 75075
- GSK Investigational Site
-
San Angelo, Texas, United States, 76904
- GSK Investigational Site
-
San Antonio, Texas, United States, 78229
- GSK Investigational Site
-
San Antonio, Texas, United States, 78215
- GSK Investigational Site
-
San Antonio, Texas, United States, 78258
- GSK Investigational Site
-
San Antonio, Texas, United States, 78233
- GSK Investigational Site
-
San Antonio, Texas, United States, 78212
- GSK Investigational Site
-
Sugar Land, Texas, United States, 77478
- GSK Investigational Site
-
Temple, Texas, United States, 76508
- GSK Investigational Site
-
Tyler, Texas, United States, 75708
- GSK Investigational Site
-
Tyler, Texas, United States, 75701
- GSK Investigational Site
-
Victoria, Texas, United States, 77901
- GSK Investigational Site
-
Waco, Texas, United States, 76710
- GSK Investigational Site
-
-
Utah
-
Midvale, Utah, United States, 84047
- GSK Investigational Site
-
Orem, Utah, United States, 84058
- GSK Investigational Site
-
Salt Lake City, Utah, United States, 84102
- GSK Investigational Site
-
West Jordan, Utah, United States, 84088
- GSK Investigational Site
-
-
Virginia
-
Abingdon, Virginia, United States, 24210
- GSK Investigational Site
-
Alexandria, Virginia, United States, 22304
- GSK Investigational Site
-
Burke, Virginia, United States, 22015
- GSK Investigational Site
-
Midlothian, Virginia, United States, 23114
- GSK Investigational Site
-
Norfolk, Virginia, United States, 23507
- GSK Investigational Site
-
Richmond, Virginia, United States, 23249
- GSK Investigational Site
-
Richmond, Virginia, United States, 23229
- GSK Investigational Site
-
Richmond, Virginia, United States, 23235
- GSK Investigational Site
-
Richmond, Virginia, United States, 23220
- GSK Investigational Site
-
Richmond, Virginia, United States, 23219
- GSK Investigational Site
-
Virginia Beach, Virginia, United States, 23454
- GSK Investigational Site
-
Winchester, Virginia, United States, 22601
- GSK Investigational Site
-
-
Washington
-
Bellingham, Washington, United States, 98225
- GSK Investigational Site
-
Burien, Washington, United States, 98166
- GSK Investigational Site
-
Seattle, Washington, United States, 98104
- GSK Investigational Site
-
Spokane, Washington, United States, 99204
- GSK Investigational Site
-
Spokane, Washington, United States, 99208
- GSK Investigational Site
-
Spokane, Washington, United States, 99202
- GSK Investigational Site
-
Spokane, Washington, United States, 99207
- GSK Investigational Site
-
Tacoma, Washington, United States, 98405
- GSK Investigational Site
-
-
West Virginia
-
Bridgeport, West Virginia, United States, 26330
- GSK Investigational Site
-
Morgantown, West Virginia, United States, 26505
- GSK Investigational Site
-
Morgantown, West Virginia, United States, 28506
- GSK Investigational Site
-
-
Wisconsin
-
West Allis, Wisconsin, United States, 53227
- GSK Investigational Site
-
-
-
-
-
Can Tho, Vietnam, 90000
- GSK Investigational Site
-
Ha Noi, Vietnam, 10000
- GSK Investigational Site
-
Ho Chi Minh, Vietnam, 70000
- GSK Investigational Site
-
Hue, Vietnam, 53000
- GSK Investigational Site
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
40 years to 80 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Type of subject: outpatient.
- Informed consent: Subjects must give their signed and dated written informed consent to participate.
- Gender: Male or female. Female subjects must be post-menopausal or using a highly effective method for avoidance of pregnancy. The decision to include or exclude women of childbearing potential may be made at the discretion of the investigator in accordance with local practice in relation to adequate contraception.
- Age: >=40 and <=80 years of age at Screening (Visit 1).
- Tobacco use: Subjects with a current or prior history of >=10 pack-years of cigarette smoking at screening (Visit 1). Previous smokers are defined as those who have stopped smoking for at least 6 months prior to Visit 1.
- Airflow Obstruction:
Subjects with a measured post-albuterol/salbutamol forced expiratory volume in 1 second (FEV1)/(forced vital capacity)FVC ratio of <=0.70 at Screening (Visit 1).
Subjects with a measured post-albuterol/salbutamol FEV1 >=50 and <=70% of predicted normal values calculated using NHANES III reference equations [Hankinson, 1999; Hankinson, 2010] at Screening (Visit 1).
Post-bronchodilator spirometry will be performed approximately 15 minutes after the subject has self-administered 4 inhalations (i.e., total 400mcg) of albuterol/salbutamol via a metered dose inhaler (MDI )with a valved-holding chamber. The FEV1/FVC ratio and FEV1 percent predicted values will be calculated.
- Symptoms of COPD: Subjects must score 2 or higher on the modified Medical Research Council Dyspnea scale (Visit 1)
- Cardiovascular disease:
For patients >= 40 years of age: any one of the following:
Established (i.e. by clinical signs or imaging studies) coronary artery disease (CAD) Established (i.e. by clinical signs or imaging studies) peripheral vascular disease (PVD) Previous stroke Previous MI Diabetes mellitus with target organ disease OR
For patients >=60 years of age: any 2 of the following:
Being treated for hypercholesterolemia Being treated for hypertension Being treated for diabetes mellitus Being treated for peripheral vascular disease
Exclusion Criteria:
- Pregnancy: Women who are pregnant or lactating.
- Asthma: Subjects with a current diagnosis of asthma. (Subjects with a prior history of asthma are eligible if they also have a current diagnosis of COPD).
- alpha 1-antitrypsin deficiency: Subjects with known alpha-1 antitrypsin deficiency as the underlying cause of COPD.
- Other respiratory disorders: Subjects with active tuberculosis, lung cancer, bronchiectasis, sarcoidosis, pulmonary fibrosis, pulmonary hypertension, interstitial lung diseases or other active pulmonary diseases.
- Lung resection or transplantation: Subjects with lung volume reduction surgery within the 12 months prior to Screening or having had a lung transplant.
- A moderate/severe COPD exacerbation that has not resolved at least 14 days prior to Visit 1 and at least 30 days following the last dose of oral corticosteroids (if applicable).
- Current severe heart failure (New York Heart Association class IV). Subjects will also be excluded if they have a known ejection fraction of <30% or if they have an implantable cardioverter defibrillator (ICD).
- Other diseases/abnormalities: Any life-threatening condition with life expectancy <3 years, other than vascular disease or COPD, that might prevent the subject from completing the study.
- End stage chronic renal disease: Subjects will be excluded if on renal replacement therapy (hemodialysis or peritoneal).
- Drug/food allergy: Subjects with a history of hypersensitivity to any of the study medications (e.g. beta-agonists, corticosteroid) or components of the inhalation powder (e.g. lactose, magnesium stearate). In addition, patients with a history of severe milk protein allergy that, in the opinion of the study physician, contraindicates the subject's participation will also be excluded.
- Drug/alcohol abuse: Subjects with a known or suspected history of alcohol or drug abuse within the last 2 years.
- Oxygen therapy: Subjects receiving treatment with long-term oxygen therapy (LTOT) or nocturnal oxygen therapy required for greater than 12 hours a day. Oxygen prn use (i.e. <=12 hours per day) is not exclusionary.
- Questionable validity of consent: Subjects with a history of psychiatric disease, intellectual deficiency, poor motivation or other conditions that will limit the validity of informed consent to participate in the study or the potential compliance to study procedures.
- Affiliation with investigator site: Study investigators, sub-investigators, study coordinators, employees of a participating investigator or immediate family members of the aforementioned are excluded from participating in this study.
- Additional medication: Use of the following medications within the following time intervals prior to Visit 1 or during the study (unless otherwise specified):
Medication No use within the following time intervals prior to Screening or thereafter at any time during the study (unless otherwise specified) Inhaled Long acting beta-agonists (LABA) 48 hours ICS/LABA combination products 48 hours Inhaled corticosteroids 48 hours Tiotropium 1 week Systemic, Oral, parenteral, intra-articular corticosteroids 30 days (oral and systemic corticosteroids may be used to treat COPD exacerbations during the study) Cytochrome P450 3A4 strong inhibitors including but not limited to antiretrovirals (protease inhibitors) (e.g.Indinavir, Nelfinavir, Ritonavir, Saquinavir); Imidazole and Triazole anti-fungals (e.g. Ketaconazole, Itraconazole); Clarithromycin, Telithromycin, Amiodarone, and Nefazodone 6 weeks Grapefruit is allowed up to Visit 1, then limited to no more than one glass of grapefruit juice (250 mL/ 8 ounces) or one grapefruit per day Any other investigational drug 30 days or 5 half lives whichever is longer.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Quadruple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
|---|---|
|
Experimental: fluticasone furoate/vilanterol
Combination of both products in one inhaler
|
100/25mcg given once daily via novel dry powder inhaler
|
|
Experimental: fluticasone furoate
comparator of individual component
|
100mcg given once daily via novel dry powder inhaler
|
|
Experimental: vilanterol
comparator of individual component
|
25mcg given once daily via novel dry powder inhaler
|
|
Placebo Comparator: placebo
once daily via inhaler
|
placebo comparator once daily via novel dry powder inhaler
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Number of Participants With Death (Both on and Off Treatment) Due to Any Cause, Time up to or on the Pre-determined Common End Date
Time Frame: From the date of randomization until date of death due to any cause (average of 2 study years)
|
Death from any cause: which occurred from the day of starting IP until the Commone End Date (CED).
Common End Date (CED) is the study end date that was pre determined where approximately 1000 deaths would have occurred in the Intent-toTreat Efficacy (ITT-E) Population.
Only deaths which occurred on or before the CED were used for the primary analysis.
Those who had not died by CED, but who were known to be alive on or after the CED, were censored at the CED.
Cox Proportional Hazards (PH) Model was adjusted for age, and gender, including all 4 arms.
A hazard ratio of less than 1 indicates a lower death rate versus placebo or other arm.
ITT-E Population consisted of all participants in the Safety Population (i.e.
randomized to IP and who received at least one dose of IP), with the exception of those recruited at sites that were closed.
|
From the date of randomization until date of death due to any cause (average of 2 study years)
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Decline in Forced Expiratory Volume in 1 Second (FEV1)
Time Frame: From start date of IP until IP stop date + 1 (assessed up to 4 years)
|
FEV1 is a measure of lung function and is defined as the maximal amount of air that can be forcefully exhaled in one second.
The effect of treatment on decline of post bronchodilator FEV1 recorded during the treatment period was analyzed using a particular form of a mixed effect model - a random coefficients model.
FEV1 was fitted as the response variable with treatment group, age, gender, baseline FEV1 and time on treatment as fixed effects.
Time on treatment was treated as a continuous variable.
This model allowed for an initial increase in FEV1, but then tested the difference in slopes from the first post-baseline measurement which was at 3 months.
A negative slope indicates a decline.
A positive treatment difference indicates a slower rate of decline vs Placebo or Component.
Only participants with at least one on-treatment post-bronchodilator FEV1 measurement were analyzed.
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From start date of IP until IP stop date + 1 (assessed up to 4 years)
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Number of Participants With First On-treatment Cardiovascular (CV) Composite Events Occured on or Before Common End Date
Time Frame: From the start of IP to first on treatment CV event till 7 days after the last dose of IP (average of 2 study years)
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On-treatment CV composite event is comprised of the first event that is adjudicated as on-treatment CV death, myocardial infarction, stroke, unstable angina, or transient ischemic attack experienced by a participant.
The events that occurred no more than 7 days after the participants last dose of IP are considered as on-treatment adverse events.
Common end date is the study end date where approximately 1000 deaths would have occurred in the ITT-E Population.
Cox PH Model was used to assess time to first on-treatment CV composite event.
Cox PH Model was adjusted for age, gender and indicators of ischemic and vascular disease, including all four treatment arms.
A hazard ratio less than 1 indicates a lower risk of a first CV event rate versus placebo or any arm.
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From the start of IP to first on treatment CV event till 7 days after the last dose of IP (average of 2 study years)
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Horne BD, Hegewald MJ, Crim C, Rea S, Bair TL, Blagev DP. The Summit Score Stratifies Mortality and Morbidity in Chronic Obstructive Pulmonary Disease. Int J Chron Obstruct Pulmon Dis. 2020 Jul 20;15:1741-1750. doi: 10.2147/COPD.S254437. eCollection 2020.
- Wise RA, Anderson JA, Amarenco P, Cowans NJ, Crim C, Denvir MA, Gomez CR, Jones MP, Morris A, Niewoehner D, Yates JC. Adjudication of cardiovascular events in patients with chronic obstructive pulmonary disease: SUMMIT trial. Clin Trials. 2020 Aug;17(4):430-436. doi: 10.1177/1740774520920897. Epub 2020 May 22.
- Celli BR, Anderson JA, Brook R, Calverley P, Cowans NJ, Crim C, Dixon I, Kim V, Martinez FJ, Morris A, Newby DE, Yates J, Vestbo J. Serum biomarkers and outcomes in patients with moderate COPD: a substudy of the randomised SUMMIT trial. BMJ Open Respir Res. 2019 May 4;6(1):e000431. doi: 10.1136/bmjresp-2019-000431. eCollection 2019.
- Fawzy A, Anderson JA, Cowans NJ, Crim C, Wise R, Yates JC, Hansel NN. Association of platelet count with all-cause mortality and risk of cardiovascular and respiratory morbidity in stable COPD. Respir Res. 2019 May 8;20(1):86. doi: 10.1186/s12931-019-1059-1.
- Vestbo J, Dransfield M, Anderson JA, Brook RD, Calverley PMA, Celli BR, Cowans NJ, Crim C, Martinez F, Newby DE, Yates J, Lange P. Impact of pre-enrolment medication use on clinical outcomes in SUMMIT. ERJ Open Res. 2019 Feb 25;5(1):00203-2018. doi: 10.1183/23120541.00203-2018. eCollection 2019 Feb.
- Adamson PD, Anderson JA, Brook RD, Calverley PMA, Celli BR, Cowans NJ, Crim C, Dixon IJ, Martinez FJ, Newby DE, Vestbo J, Yates JC, Mills NL. Cardiac Troponin I and Cardiovascular Risk in Patients With Chronic Obstructive Pulmonary Disease. J Am Coll Cardiol. 2018 Sep 4;72(10):1126-1137. doi: 10.1016/j.jacc.2018.06.051. Erratum In: J Am Coll Cardiol. 2018 Oct 30;72(18):2282.
- Kunisaki KM, Dransfield MT, Anderson JA, Brook RD, Calverley PMA, Celli BR, Crim C, Hartley BF, Martinez FJ, Newby DE, Pragman AA, Vestbo J, Yates JC, Niewoehner DE; SUMMIT Investigators. Exacerbations of Chronic Obstructive Pulmonary Disease and Cardiac Events. A Post Hoc Cohort Analysis from the SUMMIT Randomized Clinical Trial. Am J Respir Crit Care Med. 2018 Jul 1;198(1):51-57. doi: 10.1164/rccm.201711-2239OC.
- Celli B, Anderson JA, Brook R, Calverley P, Crim C, Holmes AP, Martinez FJ, Newby DE, Yates J, Vestbo J; SUMMIT Investigators. Long-Acting beta-Agonist/Inhaled Corticosteroid in Patients with Chronic Obstructive Pulmonary Disease with Cardiovascular Disease or Risk: A Factorial Analysis of the SUMMIT Clinical Trial. Am J Respir Crit Care Med. 2018 Jun 15;197(12):1641-1644. doi: 10.1164/rccm.201710-2052LE. No abstract available.
- Dransfield MT, McAllister DA, Anderson JA, Brook RD, Calverley PMA, Celli BR, Crim C, Gallot N, Martinez FJ, Scanlon PD, Yates J, Vestbo J, Newby DE; SUMMIT Investigators. beta-Blocker Therapy and Clinical Outcomes in Patients with Moderate Chronic Obstructive Pulmonary Disease and Heightened Cardiovascular Risk. An Observational Substudy of SUMMIT. Ann Am Thorac Soc. 2018 May;15(5):608-614. doi: 10.1513/AnnalsATS.201708-626OC.
- Bhatt SP, Anderson JA, Brook RD, Calverley PMA, Celli BR, Cowans NJ, Crim C, Martinez FJ, Newby DE, Vestbo J, Yates JC, Dransfield MT. Cigarette smoking and response to inhaled corticosteroids in COPD. Eur Respir J. 2018 Jan 18;51(1):1701393. doi: 10.1183/13993003.01393-2017. Print 2018 Jan. No abstract available.
- Crim C, Calverley PMA, Anderson JA, Holmes AP, Kilbride S, Martinez FJ, Brook RD, Newby DE, Yates JC, Celli BR, Vestbo J; SUMMIT investigators. Pneumonia risk with inhaled fluticasone furoate and vilanterol in COPD patients with moderate airflow limitation: The SUMMIT trial. Respir Med. 2017 Oct;131:27-34. doi: 10.1016/j.rmed.2017.07.060. Epub 2017 Aug 1.
- Calverley PMA, Anderson JA, Brook RD, Crim C, Gallot N, Kilbride S, Martinez FJ, Yates J, Newby DE, Vestbo J, Wise R, Celli BR; SUMMIT (Study to Understand Mortality and Morbidity) Investigators. Fluticasone Furoate, Vilanterol, and Lung Function Decline in Patients with Moderate Chronic Obstructive Pulmonary Disease and Heightened Cardiovascular Risk. Am J Respir Crit Care Med. 2018 Jan 1;197(1):47-55. doi: 10.1164/rccm.201610-2086OC.
- Brook RD, Anderson JA, Calverley PM, Celli BR, Crim C, Denvir MA, Magder S, Martinez FJ, Rajagopalan S, Vestbo J, Yates J, Newby DE; SUMMIT Investigators. Cardiovascular outcomes with an inhaled beta2-agonist/corticosteroid in patients with COPD at high cardiovascular risk. Heart. 2017 Oct;103(19):1536-1542. doi: 10.1136/heartjnl-2016-310897. Epub 2017 Apr 17.
- Martinez FJ, Vestbo J, Anderson JA, Brook RD, Celli BR, Cowans NJ, Crim C, Dransfield M, Kilbride S, Yates J, Newby DE, Niewoehner D, Calverley PM; SUMMIT Investigators. Effect of Fluticasone Furoate and Vilanterol on Exacerbations of Chronic Obstructive Pulmonary Disease in Patients with Moderate Airflow Obstruction. Am J Respir Crit Care Med. 2017 Apr 1;195(7):881-888. doi: 10.1164/rccm.201607-1421OC.
- Vestbo J, Anderson JA, Brook RD, Calverley PM, Celli BR, Crim C, Martinez F, Yates J, Newby DE; SUMMIT Investigators. Fluticasone furoate and vilanterol and survival in chronic obstructive pulmonary disease with heightened cardiovascular risk (SUMMIT): a double-blind randomised controlled trial. Lancet. 2016 Apr 30;387(10030):1817-26. doi: 10.1016/S0140-6736(16)30069-1. Epub 2016 Apr 28.
- Vestbo J, Anderson J, Brook RD, Calverley PM, Celli BR, Crim C, Haumann B, Martinez FJ, Yates J, Newby DE. The Study to Understand Mortality and Morbidity in COPD (SUMMIT) study protocol. Eur Respir J. 2013 May;41(5):1017-22. doi: 10.1183/09031936.00087312. Epub 2012 Sep 27.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
January 25, 2011
Primary Completion (Actual)
July 15, 2015
Study Completion (Actual)
July 15, 2015
Study Registration Dates
First Submitted
February 3, 2011
First Submitted That Met QC Criteria
March 10, 2011
First Posted (Estimate)
March 14, 2011
Study Record Updates
Last Update Posted (Actual)
August 6, 2018
Last Update Submitted That Met QC Criteria
August 2, 2018
Last Verified
August 1, 2018
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Respiratory Tract Diseases
- Lung Diseases
- Lung Diseases, Obstructive
- Pulmonary Disease, Chronic Obstructive
- Physiological Effects of Drugs
- Autonomic Agents
- Peripheral Nervous System Agents
- Anti-Inflammatory Agents
- Dermatologic Agents
- Bronchodilator Agents
- Anti-Asthmatic Agents
- Respiratory System Agents
- Anti-Allergic Agents
- Fluticasone
- Xhance
Other Study ID Numbers
- 113782
Plan for Individual participant data (IPD)
Study Data/Documents
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Statistical Analysis Plan
Information identifier: 113782Information comments: For additional information about this study please refer to the GSK Clinical Study Register
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Clinical Study Report
Information identifier: 113782Information comments: For additional information about this study please refer to the GSK Clinical Study Register
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Individual Participant Data Set
Information identifier: 113782Information comments: For additional information about this study please refer to the GSK Clinical Study Register
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Annotated Case Report Form
Information identifier: 113782Information comments: For additional information about this study please refer to the GSK Clinical Study Register
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Informed Consent Form
Information identifier: 113782Information comments: For additional information about this study please refer to the GSK Clinical Study Register
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Dataset Specification
Information identifier: 113782Information comments: For additional information about this study please refer to the GSK Clinical Study Register
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Study Protocol
Information identifier: 113782Information comments: For additional information about this study please refer to the GSK Clinical Study Register
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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