En undersøgelse for at sammenligne administration af Pembrolizumab efter operation versus administration både før og efter operation for højrisiko melanom
14. februar 2024 opdateret af: National Cancer Institute (NCI)
En fase II randomiseret undersøgelse af adjuverende versus neoadjuverende pembrolizumab (MK-3475) til klinisk påviselig fase III-IV højrisiko melanom
Dette fase II-forsøg undersøger, hvordan pembrolizumab virker før og efter operation i behandling af patienter med stadium III-IV højrisiko melanom.
Immunterapi med monoklonale antistoffer, såsom pembrolizumab, kan hjælpe kroppens immunsystem med at angribe kræften og kan forstyrre tumorcellernes evne til at vokse og sprede sig.
At give pembrolizumab før og efter operationen kan virke bedre sammenlignet med efter operationen alene til behandling af melanom.
Studieoversigt
Status
Aktiv, ikke rekrutterende
Betingelser
Detaljeret beskrivelse
PRIMÆR MÅL:
I. At sammenligne begivenhedsfri overlevelse (EFS) hos deltagere med højrisiko resektabelt melanom randomiseret til neoadjuverende pembrolizumab (MK-3475) med deltagere randomiseret til adjuverende pembrolizumab (MK-3475).
SEKUNDÆRE MÅL:
I. At vurdere hyppigheden og sværhedsgraden af toksiciteter på hver af armene. II. For at sammenligne mellem armes overordnede overlevelse (OS), sygdomskontrol efter 24 uger, lokoregional kontrol på operationsstedet(r) og det samlede antal modtagne pembrolizumab (MK-3475) doser.
III. På den neoadjuvante arm, for at estimere den patologiske responsrate, responsevalueringskriterierne i solide tumorer (RECIST) 1.1 responsrate (bekræftet og ubekræftet fuldstændig respons [CR] og delvis respons [PR]) og den immunrelaterede (i) RECIST responsrate (bekræftet og ubekræftet CR og PR), før kirurgisk resektion; at sammenligne definitioner af patologisk delvis respons; og at evaluere sammenhængen mellem patologisk respons og EFS og OS.
IV. At beskrive andelen af deltagere på hver arm, der modtog operationen planlagt ved randomisering.
YDERLIGERE MÅL:
I. At banke tumorvæv og fuldblod i forventning om fremtidige korrelative undersøgelser i denne deltagerpopulation.
OVERSIGT: Patienterne randomiseres til 1 af 2 arme.
ARM I: Inden for 17 dage (helst inden for 14 dage) dage efter kirurgisk resektion får patienterne pembrolizumab intravenøst (IV) over 30 minutter på dag 1. Behandlingen gentages hver 3. uge i 18 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet. Patienterne gennemgår også indsamling af blod under hele undersøgelsen, og magnetisk resonansbilleddannelse (MRI) eller computertomografi (CT) under undersøgelsen.
ARM II: Patienterne får pembrolizumab IV over 30 minutter på dag 1 hver 3. uge i 3 cyklusser og gennemgår derefter kirurgisk resektion inden for 3 uger. Inden for 84 dage får patienterne pembrolizumab IV over 30 minutter hver 3. uge i 15 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet. Patienterne gennemgår også opsamling af blod under hele undersøgelsen og MR eller CT under undersøgelsen.
Efter afslutning af undersøgelsesbehandlingen følges patienterne op efter 3 og 12 uger, derefter hver 3. måned i 2 år, hver 6. måned i 3 år, derefter hver 12. måned i op til 10 år.
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
313
Fase
- Fase 2
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
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Alabama
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Birmingham, Alabama, Forenede Stater, 35233
- University of Alabama at Birmingham Cancer Center
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Mobile, Alabama, Forenede Stater, 36688
- University of South Alabama Mitchell Cancer Institute
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Alaska
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Anchorage, Alaska, Forenede Stater, 98508
- Anchorage Associates in Radiation Medicine
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Anchorage, Alaska, Forenede Stater, 99508
- Alaska Breast Care and Surgery LLC
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Anchorage, Alaska, Forenede Stater, 99508
- Alaska Oncology and Hematology LLC
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Anchorage, Alaska, Forenede Stater, 99508
- Alaska Women's Cancer Care
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Anchorage, Alaska, Forenede Stater, 99508
- Anchorage Oncology Centre
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Anchorage, Alaska, Forenede Stater, 99508
- Katmai Oncology Group
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Anchorage, Alaska, Forenede Stater, 99508
- Providence Alaska Medical Center
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Anchorage, Alaska, Forenede Stater, 99504
- Anchorage Radiation Therapy Center
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Fairbanks, Alaska, Forenede Stater, 99701
- Fairbanks Memorial Hospital
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Arizona
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Gilbert, Arizona, Forenede Stater, 85234
- Banner MD Anderson Cancer Center
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Kingman, Arizona, Forenede Stater, 86401
- Kingman Regional Medical Center
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Phoenix, Arizona, Forenede Stater, 85004
- Cancer Center at Saint Joseph's
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Sun City, Arizona, Forenede Stater, 85351
- Banner Boswell Medical Center
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Tucson, Arizona, Forenede Stater, 85704
- University of Arizona Cancer Center-Orange Grove Campus
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Tucson, Arizona, Forenede Stater, 85719
- Banner University Medical Center - Tucson
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Tucson, Arizona, Forenede Stater, 85719
- University of Arizona Cancer Center-North Campus
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Arkansas
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Fort Smith, Arkansas, Forenede Stater, 72903
- Mercy Hospital Fort Smith
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Hot Springs, Arkansas, Forenede Stater, 71913
- CHI Saint Vincent Cancer Center Hot Springs
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Jonesboro, Arkansas, Forenede Stater, 72401
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
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California
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Antioch, California, Forenede Stater, 94531
- Kaiser Permanente-Deer Valley Medical Center
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Arroyo Grande, California, Forenede Stater, 93420
- PCR Oncology
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Arroyo Grande, California, Forenede Stater, 93420
- Mission Hope Medical Oncology - Arroyo Grande
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Auburn, California, Forenede Stater, 95602
- Sutter Auburn Faith Hospital
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Auburn, California, Forenede Stater, 95603
- Sutter Cancer Centers Radiation Oncology Services-Auburn
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Berkeley, California, Forenede Stater, 94704
- Alta Bates Summit Medical Center-Herrick Campus
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Burbank, California, Forenede Stater, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Burlingame, California, Forenede Stater, 94010
- Mills-Peninsula Medical Center
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Cameron Park, California, Forenede Stater, 95682
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park
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Castro Valley, California, Forenede Stater, 94546
- Eden Hospital Medical Center
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Davis, California, Forenede Stater, 95616
- Sutter Davis Hospital
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Duarte, California, Forenede Stater, 91010
- City of Hope Comprehensive Cancer Center
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Dublin, California, Forenede Stater, 94568
- Kaiser Permanente Dublin
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Dublin, California, Forenede Stater, 94568
- Epic Care-Dublin
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Emeryville, California, Forenede Stater, 94608
- Bay Area Breast Surgeons Inc
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Emeryville, California, Forenede Stater, 94608
- Epic Care Partners in Cancer Care
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Fremont, California, Forenede Stater, 94538
- Kaiser Permanente-Fremont
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Fremont, California, Forenede Stater, 94538
- Palo Alto Medical Foundation-Fremont
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Fresno, California, Forenede Stater, 93720
- Kaiser Permanente-Fresno
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Fresno, California, Forenede Stater, 93720
- Fresno Cancer Center
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Huntington Beach, California, Forenede Stater, 92648
- Keck Medicine of USC Huntington Beach
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Loma Linda, California, Forenede Stater, 92354
- Loma Linda University Medical Center
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Loma Linda, California, Forenede Stater, 92357
- Veterans Affairs Loma Linda Healthcare System
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Los Angeles, California, Forenede Stater, 90033
- USC / Norris Comprehensive Cancer Center
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Los Angeles, California, Forenede Stater, 90095
- UCLA / Jonsson Comprehensive Cancer Center
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Los Angeles, California, Forenede Stater, 90033
- Los Angeles General Medical Center
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Martinez, California, Forenede Stater, 94553-3156
- Contra Costa Regional Medical Center
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Modesto, California, Forenede Stater, 95355
- Memorial Medical Center
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Modesto, California, Forenede Stater, 95356
- Kaiser Permanente-Modesto
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Mountain View, California, Forenede Stater, 94040
- Palo Alto Medical Foundation-Camino Division
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Mountain View, California, Forenede Stater, 94040
- Palo Alto Medical Foundation-Gynecologic Oncology
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Napa, California, Forenede Stater, 94558
- Providence Queen of The Valley
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Newport Beach, California, Forenede Stater, 92663
- USC Norris Oncology/Hematology-Newport Beach
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Novato, California, Forenede Stater, 94945
- Sutter Cancer Research Consortium
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Oakland, California, Forenede Stater, 94611
- Kaiser Permanente-Oakland
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Oakland, California, Forenede Stater, 94611
- Kaiser Permanente Oakland-Broadway
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Oakland, California, Forenede Stater, 94609
- Alta Bates Summit Medical Center - Summit Campus
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Oakland, California, Forenede Stater, 94609
- Bay Area Tumor Institute
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Orange, California, Forenede Stater, 92868
- UC Irvine Health/Chao Family Comprehensive Cancer Center
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Orange, California, Forenede Stater, 92868
- Saint Joseph Hospital - Orange
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Palo Alto, California, Forenede Stater, 94304
- Stanford Cancer Institute Palo Alto
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Palo Alto, California, Forenede Stater, 94301
- Palo Alto Medical Foundation Health Care
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Pasadena, California, Forenede Stater, 91105
- Keck Medical Center of USC Pasadena
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Rancho Cordova, California, Forenede Stater, 95670
- Kaiser Permanente-Rancho Cordova Cancer Center
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Rancho Mirage, California, Forenede Stater, 92270
- Eisenhower Medical Center
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Redwood City, California, Forenede Stater, 94063
- Kaiser Permanente-Redwood City
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Redwood City, California, Forenede Stater, 94063
- Kaiser Permanente- Marshall Medical Offices
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Richmond, California, Forenede Stater, 94801
- Kaiser Permanente-Richmond
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Rohnert Park, California, Forenede Stater, 94928
- Rohnert Park Cancer Center
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Roseville, California, Forenede Stater, 95678
- The Permanente Medical Group-Roseville Radiation Oncology
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Roseville, California, Forenede Stater, 95661
- Kaiser Permanente-Roseville
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Roseville, California, Forenede Stater, 95661
- Sutter Cancer Centers Radiation Oncology Services-Roseville
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Roseville, California, Forenede Stater, 95661
- Sutter Roseville Medical Center
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Sacramento, California, Forenede Stater, 95816
- Sutter Medical Center Sacramento
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Sacramento, California, Forenede Stater, 95814
- Kaiser Permanente Downtown Commons
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Sacramento, California, Forenede Stater, 95823
- Kaiser Permanente-South Sacramento
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Sacramento, California, Forenede Stater, 95823
- South Sacramento Cancer Center
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Sacramento, California, Forenede Stater, 95825
- Kaiser Permanente - Sacramento
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San Francisco, California, Forenede Stater, 94115
- Kaiser Permanente-San Francisco
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San Francisco, California, Forenede Stater, 94115
- California Pacific Medical Center-Pacific Campus
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San Jose, California, Forenede Stater, 95119
- Kaiser Permanente-Santa Teresa-San Jose
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San Leandro, California, Forenede Stater, 94577
- Kaiser Permanente San Leandro
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San Luis Obispo, California, Forenede Stater, 93401
- Pacific Central Coast Health Center-San Luis Obispo
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San Rafael, California, Forenede Stater, 94903
- Kaiser San Rafael-Gallinas
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San Rafael, California, Forenede Stater, 94903
- Kaiser Permanente-San Rafael
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Santa Clara, California, Forenede Stater, 95051
- Kaiser Permanente Medical Center - Santa Clara
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Santa Cruz, California, Forenede Stater, 95065
- Palo Alto Medical Foundation-Santa Cruz
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Santa Maria, California, Forenede Stater, 93444
- Mission Hope Medical Oncology - Santa Maria
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Santa Rosa, California, Forenede Stater, 95403
- Kaiser Permanente-Santa Rosa
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Santa Rosa, California, Forenede Stater, 95403
- Sutter Pacific Medical Foundation
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Santa Rosa, California, Forenede Stater, 95403
- Providence Medical Foundation - Santa Rosa
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Santa Rosa, California, Forenede Stater, 95405
- Providence Santa Rosa Memorial Hospital
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South San Francisco, California, Forenede Stater, 94080
- Kaiser Permanente Cancer Treatment Center
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South San Francisco, California, Forenede Stater, 94080
- Kaiser Permanente-South San Francisco
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Stockton, California, Forenede Stater, 95210
- Kaiser Permanente-Stockton
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Sunnyvale, California, Forenede Stater, 94086
- Palo Alto Medical Foundation-Sunnyvale
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Vacaville, California, Forenede Stater, 95688
- Kaiser Permanente Medical Center-Vacaville
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Vacaville, California, Forenede Stater, 95687
- Sutter Cancer Centers Radiation Oncology Services-Vacaville
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Vallejo, California, Forenede Stater, 94589
- Kaiser Permanente-Vallejo
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Vallejo, California, Forenede Stater, 94589
- Sutter Solano Medical Center/Cancer Center
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Walnut Creek, California, Forenede Stater, 94596
- Kaiser Permanente-Walnut Creek
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Walnut Creek, California, Forenede Stater, 94597
- Epic Care Cyberknife Center
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Colorado
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Aurora, Colorado, Forenede Stater, 80012
- Rocky Mountain Cancer Centers-Aurora
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Aurora, Colorado, Forenede Stater, 80012
- The Medical Center of Aurora
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Boulder, Colorado, Forenede Stater, 80301
- Boulder Community Hospital
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Boulder, Colorado, Forenede Stater, 80303
- Boulder Community Foothills Hospital
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Boulder, Colorado, Forenede Stater, 80304
- Rocky Mountain Cancer Centers-Boulder
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Centennial, Colorado, Forenede Stater, 80112
- Rocky Mountain Cancer Centers - Centennial
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Colorado Springs, Colorado, Forenede Stater, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, Forenede Stater, 80907
- Rocky Mountain Cancer Centers-Penrose
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Colorado Springs, Colorado, Forenede Stater, 80923
- Saint Francis Cancer Center
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Denver, Colorado, Forenede Stater, 80210
- Porter Adventist Hospital
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Denver, Colorado, Forenede Stater, 80205
- Kaiser Permanente-Franklin
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Denver, Colorado, Forenede Stater, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, Forenede Stater, 80218
- SCL Health Saint Joseph Hospital
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Denver, Colorado, Forenede Stater, 80220
- Rose Medical Center
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Denver, Colorado, Forenede Stater, 80218
- Rocky Mountain Cancer Centers-Midtown
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Denver, Colorado, Forenede Stater, 80220
- Rocky Mountain Cancer Centers-Rose
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Denver, Colorado, Forenede Stater, 80204
- Denver Health Medical Center
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Denver, Colorado, Forenede Stater, 80218
- Colorado Blood Cancer Institute
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Denver, Colorado, Forenede Stater, 80204
- Cancer Center of Colorado at Sloan's Lake
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Denver, Colorado, Forenede Stater, 80209
- The Women's Imaging Center
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Denver, Colorado, Forenede Stater, 80206
- National Jewish Health-Main Campus
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Denver, Colorado, Forenede Stater, 80220
- Western Surgical Care
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Durango, Colorado, Forenede Stater, 81301
- Mercy Medical Center
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Durango, Colorado, Forenede Stater, 81301
- Southwest Oncology PC
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Englewood, Colorado, Forenede Stater, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, Forenede Stater, 80113
- Swedish Medical Center
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Englewood, Colorado, Forenede Stater, 80113
- Rocky Mountain Cancer Centers - Swedish
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Englewood, Colorado, Forenede Stater, 80113
- The Melanoma and Skin Cancer Institute
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Golden, Colorado, Forenede Stater, 80401
- Mountain Blue Cancer Care Center
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Golden, Colorado, Forenede Stater, 80401
- National Jewish Health-Western Hematology Oncology
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Golden, Colorado, Forenede Stater, 80401
- SCL Health Cancer Centers of Colorado - Lutheran Medical Center
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Grand Junction, Colorado, Forenede Stater, 81501
- Saint Mary's Hospital and Regional Medical Center
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Greeley, Colorado, Forenede Stater, 80631
- North Colorado Medical Center
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Lafayette, Colorado, Forenede Stater, 80026
- Good Samaritan Medical Center
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Lafayette, Colorado, Forenede Stater, 80026
- Kaiser Permanente-Rock Creek
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Lakewood, Colorado, Forenede Stater, 80228
- Saint Anthony Hospital
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Lakewood, Colorado, Forenede Stater, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Littleton, Colorado, Forenede Stater, 80120
- Rocky Mountain Cancer Centers-Littleton
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Littleton, Colorado, Forenede Stater, 80122
- Littleton Adventist Hospital
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Lone Tree, Colorado, Forenede Stater, 80124
- Kaiser Permanente-Lone Tree
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Lone Tree, Colorado, Forenede Stater, 80124
- Sky Ridge Medical Center
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Lone Tree, Colorado, Forenede Stater, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
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Longmont, Colorado, Forenede Stater, 80501
- Longmont United Hospital
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Longmont, Colorado, Forenede Stater, 80501
- Rocky Mountain Cancer Centers-Longmont
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Loveland, Colorado, Forenede Stater, 80539
- McKee Medical Center
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Parker, Colorado, Forenede Stater, 80138
- Parker Adventist Hospital
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Parker, Colorado, Forenede Stater, 80138
- Rocky Mountain Cancer Centers-Parker
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Pueblo, Colorado, Forenede Stater, 81004
- Saint Mary Corwin Medical Center
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Pueblo, Colorado, Forenede Stater, 81008
- Rocky Mountain Cancer Centers - Pueblo
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Thornton, Colorado, Forenede Stater, 80260
- Rocky Mountain Cancer Centers-Thornton
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Thornton, Colorado, Forenede Stater, 80260
- National Jewish Health-Northern Hematology Oncology
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Wheat Ridge, Colorado, Forenede Stater, 80033
- SCL Health Lutheran Medical Center
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District of Columbia
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Washington, District of Columbia, Forenede Stater, 20007
- MedStar Georgetown University Hospital
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Florida
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Aventura, Florida, Forenede Stater, 33180
- Mount Sinai Comprehensive Cancer Center at Aventura
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Coral Gables, Florida, Forenede Stater, 33146
- UM Sylvester Comprehensive Cancer Center at Coral Gables
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Deerfield Beach, Florida, Forenede Stater, 33442
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach
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Fort Lauderdale, Florida, Forenede Stater, 33308
- Holy Cross Hospital
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Miami, Florida, Forenede Stater, 33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
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Miami, Florida, Forenede Stater, 33176
- UM Sylvester Comprehensive Cancer Center at Kendall
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Miami Beach, Florida, Forenede Stater, 33140
- Mount Sinai Medical Center
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Orlando, Florida, Forenede Stater, 32806
- Orlando Health Cancer Institute
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Plantation, Florida, Forenede Stater, 33324
- UM Sylvester Comprehensive Cancer Center at Plantation
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Georgia
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Atlanta, Georgia, Forenede Stater, 30308
- Emory University Hospital Midtown
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Atlanta, Georgia, Forenede Stater, 30322
- Emory University Hospital/Winship Cancer Institute
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Atlanta, Georgia, Forenede Stater, 30342
- Emory Saint Joseph's Hospital
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Savannah, Georgia, Forenede Stater, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Savannah, Georgia, Forenede Stater, 31405
- Summit Cancer Care-Candler
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Hawaii
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'Aiea, Hawaii, Forenede Stater, 96701
- Pali Momi Medical Center
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'Aiea, Hawaii, Forenede Stater, 96701
- Queen's Cancer Center - Pearlridge
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'Aiea, Hawaii, Forenede Stater, 96701
- The Cancer Center of Hawaii-Pali Momi
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'Aiea, Hawaii, Forenede Stater, 96701
- Hawaii Cancer Care - Westridge
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Honolulu, Hawaii, Forenede Stater, 96813
- Queen's Medical Center
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Honolulu, Hawaii, Forenede Stater, 96817
- The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, Forenede Stater, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, Forenede Stater, 96813
- Queen's Cancer Cenrer - POB I
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Honolulu, Hawaii, Forenede Stater, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, Forenede Stater, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, Forenede Stater, 96817
- Hawaii Cancer Care Inc-Liliha
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Honolulu, Hawaii, Forenede Stater, 96817
- Kuakini Medical Center
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Honolulu, Hawaii, Forenede Stater, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, Forenede Stater, 96826
- Kapiolani Medical Center for Women and Children
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Honolulu, Hawaii, Forenede Stater, 96813
- Island Urology
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Honolulu, Hawaii, Forenede Stater, 96819
- Kaiser Permanente Moanalua Medical Center
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Lihue, Hawaii, Forenede Stater, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
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Idaho
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Boise, Idaho, Forenede Stater, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Boise, Idaho, Forenede Stater, 83712
- Saint Luke's Cancer Institute - Boise
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Caldwell, Idaho, Forenede Stater, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
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Coeur d'Alene, Idaho, Forenede Stater, 83814
- Kootenai Health - Coeur d'Alene
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Emmett, Idaho, Forenede Stater, 83617
- Walter Knox Memorial Hospital
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Fruitland, Idaho, Forenede Stater, 83619
- Saint Luke's Cancer Institute - Fruitland
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Meridian, Idaho, Forenede Stater, 83642
- Idaho Urologic Institute-Meridian
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Meridian, Idaho, Forenede Stater, 83642
- Saint Luke's Cancer Institute - Meridian
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Nampa, Idaho, Forenede Stater, 83686
- Saint Luke's Cancer Institute - Nampa
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Nampa, Idaho, Forenede Stater, 83687
- Saint Alphonsus Cancer Care Center-Nampa
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Post Falls, Idaho, Forenede Stater, 83854
- Kootenai Clinic Cancer Services - Post Falls
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Sandpoint, Idaho, Forenede Stater, 83864
- Kootenai Cancer Clinic
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Twin Falls, Idaho, Forenede Stater, 83301
- Saint Luke's Cancer Institute - Twin Falls
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Illinois
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Alton, Illinois, Forenede Stater, 62002
- Saint Anthony's Health
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Aurora, Illinois, Forenede Stater, 60504
- Rush - Copley Medical Center
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Bloomington, Illinois, Forenede Stater, 61704
- Illinois CancerCare-Bloomington
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Burr Ridge, Illinois, Forenede Stater, 60527
- Loyola Center for Health at Burr Ridge
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Canton, Illinois, Forenede Stater, 61520
- Illinois CancerCare-Canton
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Carbondale, Illinois, Forenede Stater, 62902
- Memorial Hospital of Carbondale
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Carterville, Illinois, Forenede Stater, 62918
- SIH Cancer Institute
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Carthage, Illinois, Forenede Stater, 62321
- Illinois CancerCare-Carthage
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Centralia, Illinois, Forenede Stater, 62801
- Centralia Oncology Clinic
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Chicago, Illinois, Forenede Stater, 60611
- Northwestern University
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Chicago, Illinois, Forenede Stater, 60612
- Rush University Medical Center
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Danville, Illinois, Forenede Stater, 61832
- Carle at The Riverfront
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Decatur, Illinois, Forenede Stater, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, Forenede Stater, 62526
- Cancer Care Specialists of Illinois - Decatur
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Dixon, Illinois, Forenede Stater, 61021
- Illinois CancerCare-Dixon
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Effingham, Illinois, Forenede Stater, 62401
- Crossroads Cancer Center
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Effingham, Illinois, Forenede Stater, 62401
- Carle Physician Group-Effingham
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Elmhurst, Illinois, Forenede Stater, 60126
- Elmhurst Memorial Hospital
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Eureka, Illinois, Forenede Stater, 61530
- Illinois CancerCare-Eureka
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Galesburg, Illinois, Forenede Stater, 61401
- Western Illinois Cancer Treatment Center
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Galesburg, Illinois, Forenede Stater, 61401
- Illinois CancerCare-Galesburg
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Homer Glen, Illinois, Forenede Stater, 60491
- Loyola Medicine Homer Glen
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Kewanee, Illinois, Forenede Stater, 61443
- Illinois CancerCare-Kewanee Clinic
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Lake Forest, Illinois, Forenede Stater, 60045
- Northwestern Medicine Lake Forest Hospital
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Macomb, Illinois, Forenede Stater, 61455
- Illinois CancerCare-Macomb
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Mattoon, Illinois, Forenede Stater, 61938
- Carle Physician Group-Mattoon/Charleston
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Maywood, Illinois, Forenede Stater, 60153
- Loyola University Medical Center
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Melrose Park, Illinois, Forenede Stater, 60160
- Marjorie Weinberg Cancer Center at Loyola-Gottlieb
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Mount Vernon, Illinois, Forenede Stater, 62864
- Good Samaritan Regional Health Center
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Naperville, Illinois, Forenede Stater, 60540
- Edward Hospital/Cancer Center
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O'Fallon, Illinois, Forenede Stater, 62269
- Cancer Care Center of O'Fallon
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Ottawa, Illinois, Forenede Stater, 61350
- Illinois CancerCare-Ottawa Clinic
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Park Ridge, Illinois, Forenede Stater, 60068
- Advocate Lutheran General Hospital
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Pekin, Illinois, Forenede Stater, 61554
- Illinois CancerCare-Pekin
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Peoria, Illinois, Forenede Stater, 61636
- Methodist Medical Center of Illinois
-
Peoria, Illinois, Forenede Stater, 61615
- Illinois CancerCare-Peoria
-
Peru, Illinois, Forenede Stater, 61354
- Illinois CancerCare-Peru
-
Peru, Illinois, Forenede Stater, 61354
- Valley Radiation Oncology
-
Plainfield, Illinois, Forenede Stater, 60585
- Edward Hospital/Cancer Center?Plainfield
-
Princeton, Illinois, Forenede Stater, 61356
- Illinois CancerCare-Princeton
-
Silvis, Illinois, Forenede Stater, 61282
- Genesis Cancer Center - Silvis
-
Springfield, Illinois, Forenede Stater, 62781
- Memorial Medical Center
-
Springfield, Illinois, Forenede Stater, 62702
- Southern Illinois University School of Medicine
-
Springfield, Illinois, Forenede Stater, 62702
- Springfield Clinic
-
Swansea, Illinois, Forenede Stater, 62226
- Southwest Illinois Health Services LLP
-
Urbana, Illinois, Forenede Stater, 61801
- Carle Cancer Center
-
Urbana, Illinois, Forenede Stater, 61801
- The Carle Foundation Hospital
-
Washington, Illinois, Forenede Stater, 61571
- Illinois CancerCare - Washington
-
Yorkville, Illinois, Forenede Stater, 60560
- Rush-Copley Healthcare Center
-
-
Indiana
-
Indianapolis, Indiana, Forenede Stater, 46237
- Franciscan Health Indianapolis
-
Indianapolis, Indiana, Forenede Stater, 46202
- Indiana University/Melvin and Bren Simon Cancer Center
-
Lafayette, Indiana, Forenede Stater, 47905
- Franciscan Saint Elizabeth Health - Lafayette East
-
Michigan City, Indiana, Forenede Stater, 46360
- Woodland Cancer Care Center
-
Mooresville, Indiana, Forenede Stater, 46158
- Franciscan Health Mooresville
-
Richmond, Indiana, Forenede Stater, 47374
- Reid Health
-
Terre Haute, Indiana, Forenede Stater, 47804
- Union Hospital
-
-
Iowa
-
Cedar Rapids, Iowa, Forenede Stater, 52403
- Mercy Hospital
-
Cedar Rapids, Iowa, Forenede Stater, 52403
- Oncology Associates at Mercy Medical Center
-
Clive, Iowa, Forenede Stater, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, Forenede Stater, 50325
- Medical Oncology and Hematology Associates-West Des Moines
-
Council Bluffs, Iowa, Forenede Stater, 51503
- Alegent Health Mercy Hospital
-
Creston, Iowa, Forenede Stater, 50801
- Greater Regional Medical Center
-
Davenport, Iowa, Forenede Stater, 52803
- Genesis Medical Center - East Campus
-
Davenport, Iowa, Forenede Stater, 52804
- Genesis Cancer Care Institute
-
Davenport, Iowa, Forenede Stater, 52807
- Iowa Cancer Specialists
-
Des Moines, Iowa, Forenede Stater, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Forenede Stater, 50314
- Mission Cancer and Blood - Laurel
-
West Des Moines, Iowa, Forenede Stater, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Coffeyville, Kansas, Forenede Stater, 67337
- Coffeyville Regional Medical Center
-
Dodge City, Kansas, Forenede Stater, 67801
- Cancer Center of Kansas - Dodge City
-
Garden City, Kansas, Forenede Stater, 67846
- Central Care Cancer Center - Garden City
-
Great Bend, Kansas, Forenede Stater, 67530
- Central Care Cancer Center - Great Bend
-
Hays, Kansas, Forenede Stater, 67601
- HaysMed University of Kansas Health System
-
Lawrence, Kansas, Forenede Stater, 66044
- Lawrence Memorial Hospital
-
Lenexa, Kansas, Forenede Stater, 66219
- Kansas Institute of Medicine Cancer and Blood Center
-
Lenexa, Kansas, Forenede Stater, 66219
- Minimally Invasive Surgery Hospital
-
Olathe, Kansas, Forenede Stater, 66061
- Olathe Health Cancer Center
-
Overland Park, Kansas, Forenede Stater, 66210
- University of Kansas Cancer Center-Overland Park
-
Overland Park, Kansas, Forenede Stater, 66209
- Menorah Medical Center
-
Pittsburg, Kansas, Forenede Stater, 66762
- Ascension Via Christi - Pittsburg
-
Salina, Kansas, Forenede Stater, 67401
- Salina Regional Health Center
-
Topeka, Kansas, Forenede Stater, 66606
- University of Kansas Health System Saint Francis Campus
-
Westwood, Kansas, Forenede Stater, 66205
- University of Kansas Hospital-Westwood Cancer Center
-
Wichita, Kansas, Forenede Stater, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, Forenede Stater, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, Forenede Stater, 67214
- Cancer Center of Kansas - Wichita
-
-
Kentucky
-
Bardstown, Kentucky, Forenede Stater, 40004
- Flaget Memorial Hospital
-
Corbin, Kentucky, Forenede Stater, 40701
- Commonwealth Cancer Center-Corbin
-
Lexington, Kentucky, Forenede Stater, 40536
- University of Kentucky/Markey Cancer Center
-
Lexington, Kentucky, Forenede Stater, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, Forenede Stater, 40509
- Saint Joseph Hospital East
-
London, Kentucky, Forenede Stater, 40741
- Saint Joseph London
-
Louisville, Kentucky, Forenede Stater, 40202
- Jewish Hospital
-
Louisville, Kentucky, Forenede Stater, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, Forenede Stater, 40215
- Saints Mary and Elizabeth Hospital
-
Shepherdsville, Kentucky, Forenede Stater, 40165
- Jewish Hospital Medical Center South
-
-
Louisiana
-
Baton Rouge, Louisiana, Forenede Stater, 70805
- LSU Health Baton Rouge-North Clinic
-
Baton Rouge, Louisiana, Forenede Stater, 70809
- Louisiana Hematology Oncology Associates LLC
-
Baton Rouge, Louisiana, Forenede Stater, 70809
- Mary Bird Perkins Cancer Center
-
Baton Rouge, Louisiana, Forenede Stater, 70809
- Our Lady of the Lake Physicians Group - Medical Oncology
-
Baton Rouge, Louisiana, Forenede Stater, 70836
- Ochsner High Grove
-
Baton Rouge, Louisiana, Forenede Stater, 70808
- Our Lady of the Lake
-
Covington, Louisiana, Forenede Stater, 70433
- Northshore Oncology Associates-Covington
-
Covington, Louisiana, Forenede Stater, 70433
- Ochsner Hematology Oncology North Shore - Covington (West Region)
-
Houma, Louisiana, Forenede Stater, 70360
- Terrebonne General Medical Center
-
Houma, Louisiana, Forenede Stater, 70360
- Oncology Center of The South Incorporated
-
New Orleans, Louisiana, Forenede Stater, 70121
- Ochsner Medical Center Jefferson
-
New Orleans, Louisiana, Forenede Stater, 70112
- Louisiana State University Health Science Center
-
-
Maine
-
Bangor, Maine, Forenede Stater, 04401
- Eastern Maine Medical Center
-
Brewer, Maine, Forenede Stater, 04412
- Lafayette Family Cancer Center-EMMC
-
-
Maryland
-
Baltimore, Maryland, Forenede Stater, 21237
- MedStar Franklin Square Medical Center/Weinberg Cancer Institute
-
-
Massachusetts
-
Boston, Massachusetts, Forenede Stater, 02118
- Boston Medical Center
-
Springfield, Massachusetts, Forenede Stater, 01104
- Mercy Medical Center
-
Worcester, Massachusetts, Forenede Stater, 01655
- UMass Memorial Medical Center - University Campus
-
-
Michigan
-
Ann Arbor, Michigan, Forenede Stater, 48109
- University of Michigan Comprehensive Cancer Center
-
Ann Arbor, Michigan, Forenede Stater, 48106
- Saint Joseph Mercy Hospital
-
Battle Creek, Michigan, Forenede Stater, 49017
- Bronson Battle Creek
-
Brighton, Michigan, Forenede Stater, 48114
- Saint Joseph Mercy Brighton
-
Brighton, Michigan, Forenede Stater, 48114
- Trinity Health IHA Medical Group Hematology Oncology - Brighton
-
Brownstown, Michigan, Forenede Stater, 48183
- Henry Ford Cancer Institute-Downriver
-
Canton, Michigan, Forenede Stater, 48188
- Saint Joseph Mercy Canton
-
Canton, Michigan, Forenede Stater, 48188
- Trinity Health IHA Medical Group Hematology Oncology - Canton
-
Caro, Michigan, Forenede Stater, 48723
- Caro Cancer Center
-
Chelsea, Michigan, Forenede Stater, 48118
- Saint Joseph Mercy Chelsea
-
Chelsea, Michigan, Forenede Stater, 48118
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
-
Clarkston, Michigan, Forenede Stater, 48346
- Hematology Oncology Consultants-Clarkston
-
Clarkston, Michigan, Forenede Stater, 48346
- Newland Medical Associates-Clarkston
-
Clinton Township, Michigan, Forenede Stater, 48038
- Henry Ford Macomb Hospital-Clinton Township
-
Dearborn, Michigan, Forenede Stater, 48126
- Henry Ford Medical Center-Fairlane
-
Detroit, Michigan, Forenede Stater, 48202
- Henry Ford Hospital
-
Detroit, Michigan, Forenede Stater, 48236
- Ascension Saint John Hospital
-
East China Township, Michigan, Forenede Stater, 48054
- Great Lakes Cancer Management Specialists-Doctors Park
-
Escanaba, Michigan, Forenede Stater, 49829
- Green Bay Oncology - Escanaba
-
Flint, Michigan, Forenede Stater, 48503
- Hurley Medical Center
-
Flint, Michigan, Forenede Stater, 48503
- Genesee Cancer and Blood Disease Treatment Center
-
Flint, Michigan, Forenede Stater, 48503
- Genesee Hematology Oncology PC
-
Flint, Michigan, Forenede Stater, 48503
- Genesys Hurley Cancer Institute
-
Grand Rapids, Michigan, Forenede Stater, 49503
- Spectrum Health at Butterworth Campus
-
Grand Rapids, Michigan, Forenede Stater, 49503
- Helen DeVos Children's Hospital at Spectrum Health
-
Grand Rapids, Michigan, Forenede Stater, 49503
- Trinity Health Grand Rapids Hospital
-
Grosse Pointe Woods, Michigan, Forenede Stater, 48236
- Academic Hematology Oncology Specialists
-
Grosse Pointe Woods, Michigan, Forenede Stater, 48236
- Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
-
Grosse Pointe Woods, Michigan, Forenede Stater, 48236
- Michigan Breast Specialists-Grosse Pointe Woods
-
Jackson, Michigan, Forenede Stater, 49201
- Allegiance Health
-
Kalamazoo, Michigan, Forenede Stater, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, Forenede Stater, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, Forenede Stater, 49048
- Borgess Medical Center
-
Kalamazoo, Michigan, Forenede Stater, 49009
- Ascension Borgess Cancer Center
-
Lansing, Michigan, Forenede Stater, 48912
- Sparrow Hospital
-
Livonia, Michigan, Forenede Stater, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Livonia, Michigan, Forenede Stater, 48154
- Hope Cancer Clinic
-
Macomb, Michigan, Forenede Stater, 48044
- Great Lakes Cancer Management Specialists-Macomb Medical Campus
-
Macomb, Michigan, Forenede Stater, 48044
- Michigan Breast Specialists-Macomb Township
-
Marlette, Michigan, Forenede Stater, 48453
- Saint Mary's Oncology/Hematology Associates of Marlette
-
Muskegon, Michigan, Forenede Stater, 49444
- Trinity Health Muskegon Hospital
-
Niles, Michigan, Forenede Stater, 49120
- Corewell Health Lakeland Hospitals - Niles Hospital
-
Norton Shores, Michigan, Forenede Stater, 49444
- Cancer and Hematology Centers of Western Michigan - Norton Shores
-
Novi, Michigan, Forenede Stater, 48374
- Ascension Providence Hospitals - Novi
-
Novi, Michigan, Forenede Stater, 48377
- Henry Ford Medical Center-Columbus
-
Pontiac, Michigan, Forenede Stater, 48341
- Saint Joseph Mercy Oakland
-
Pontiac, Michigan, Forenede Stater, 48341
- 21st Century Oncology-Pontiac
-
Pontiac, Michigan, Forenede Stater, 48341
- Hope Cancer Center
-
Pontiac, Michigan, Forenede Stater, 48341
- Newland Medical Associates-Pontiac
-
Port Huron, Michigan, Forenede Stater, 48060
- Lake Huron Medical Center
-
Port Huron, Michigan, Forenede Stater, 48060
- Huron Medical Center PC
-
Reed City, Michigan, Forenede Stater, 49677
- Corewell Health Reed City Hospital
-
Rochester Hills, Michigan, Forenede Stater, 48309
- Great Lakes Cancer Management Specialists-Rochester Hills
-
Saginaw, Michigan, Forenede Stater, 48601
- Ascension Saint Mary's Hospital
-
Saginaw, Michigan, Forenede Stater, 48604
- Oncology Hematology Associates of Saginaw Valley PC
-
Saint Joseph, Michigan, Forenede Stater, 49085
- Lakeland Medical Center Saint Joseph
-
Saint Joseph, Michigan, Forenede Stater, 49085
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
-
Shelby, Michigan, Forenede Stater, 48315
- Henry Ford Macomb Health Center - Shelby Township
-
Southfield, Michigan, Forenede Stater, 48075
- Ascension Providence Hospitals - Southfield
-
Sterling Heights, Michigan, Forenede Stater, 48312
- Bhadresh Nayak MD PC-Sterling Heights
-
Tawas City, Michigan, Forenede Stater, 48764
- Ascension Saint Joseph Hospital
-
Traverse City, Michigan, Forenede Stater, 49684
- Munson Medical Center
-
Warren, Michigan, Forenede Stater, 48093
- Saint John Macomb-Oakland Hospital
-
Warren, Michigan, Forenede Stater, 48088
- Advanced Breast Care Center PLLC
-
Warren, Michigan, Forenede Stater, 48093
- Great Lakes Cancer Management Specialists-Macomb Professional Building
-
Warren, Michigan, Forenede Stater, 48093
- Macomb Hematology Oncology PC
-
Warren, Michigan, Forenede Stater, 48093
- Michigan Breast Specialists-Warren
-
West Bloomfield, Michigan, Forenede Stater, 48322
- Henry Ford West Bloomfield Hospital
-
West Branch, Michigan, Forenede Stater, 48661
- Saint Mary's Oncology/Hematology Associates of West Branch
-
Wyandotte, Michigan, Forenede Stater, 48192
- Henry Ford Wyandotte Hospital
-
Wyoming, Michigan, Forenede Stater, 49519
- University of Michigan Health - West
-
Ypsilanti, Michigan, Forenede Stater, 48197
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
-
Ypsilanti, Michigan, Forenede Stater, 48106
- Huron Gastroenterology PC
-
-
Minnesota
-
Aitkin, Minnesota, Forenede Stater, 56431
- Riverwood Healthcare Center
-
Bemidji, Minnesota, Forenede Stater, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, Forenede Stater, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, Forenede Stater, 55337
- Fairview Ridges Hospital
-
Burnsville, Minnesota, Forenede Stater, 55337
- Minnesota Oncology - Burnsville
-
Cambridge, Minnesota, Forenede Stater, 55008
- Cambridge Medical Center
-
Coon Rapids, Minnesota, Forenede Stater, 55433
- Mercy Hospital
-
Deer River, Minnesota, Forenede Stater, 56636
- Essentia Health - Deer River Clinic
-
Detroit Lakes, Minnesota, Forenede Stater, 56501
- Essentia Health Saint Mary's - Detroit Lakes Clinic
-
Duluth, Minnesota, Forenede Stater, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, Forenede Stater, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, Forenede Stater, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, Forenede Stater, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, Forenede Stater, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fosston, Minnesota, Forenede Stater, 56542
- Essentia Health - Fosston
-
Fridley, Minnesota, Forenede Stater, 55432
- Unity Hospital
-
Hibbing, Minnesota, Forenede Stater, 55746
- Essentia Health Hibbing Clinic
-
Maple Grove, Minnesota, Forenede Stater, 55369
- Fairview Clinics and Surgery Center Maple Grove
-
Maplewood, Minnesota, Forenede Stater, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Forenede Stater, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Forenede Stater, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Forenede Stater, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Forenede Stater, 55454
- Health Partners Inc
-
Monticello, Minnesota, Forenede Stater, 55362
- Monticello Cancer Center
-
New Ulm, Minnesota, Forenede Stater, 56073
- New Ulm Medical Center
-
Park Rapids, Minnesota, Forenede Stater, 56470
- Essentia Health - Park Rapids
-
Princeton, Minnesota, Forenede Stater, 55371
- Fairview Northland Medical Center
-
Robbinsdale, Minnesota, Forenede Stater, 55422
- North Memorial Medical Health Center
-
Saint Louis Park, Minnesota, Forenede Stater, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, Forenede Stater, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Forenede Stater, 55102
- United Hospital
-
Sandstone, Minnesota, Forenede Stater, 55072
- Essentia Health Sandstone
-
Shakopee, Minnesota, Forenede Stater, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Forenede Stater, 55082
- Lakeview Hospital
-
Thief River Falls, Minnesota, Forenede Stater, 56701
- Sanford Thief River Falls Medical Center
-
Virginia, Minnesota, Forenede Stater, 55792
- Essentia Health Virginia Clinic
-
Waconia, Minnesota, Forenede Stater, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Forenede Stater, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Forenede Stater, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
Worthington, Minnesota, Forenede Stater, 56187
- Sanford Cancer Center Worthington
-
Wyoming, Minnesota, Forenede Stater, 55092
- Fairview Lakes Medical Center
-
-
Mississippi
-
Gulfport, Mississippi, Forenede Stater, 39502
- Gulfport Memorial Hospital
-
Jackson, Mississippi, Forenede Stater, 39216
- University of Mississippi Medical Center
-
Southhaven, Mississippi, Forenede Stater, 38671
- Baptist Memorial Hospital and Cancer Center-Desoto
-
-
Missouri
-
Ballwin, Missouri, Forenede Stater, 63011
- Saint Louis Cancer and Breast Institute-Ballwin
-
Bolivar, Missouri, Forenede Stater, 65613
- Central Care Cancer Center - Bolivar
-
Bonne Terre, Missouri, Forenede Stater, 63628
- Parkland Health Center-Bonne Terre
-
Branson, Missouri, Forenede Stater, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, Forenede Stater, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Forenede Stater, 63703
- Southeast Cancer Center
-
Creve Coeur, Missouri, Forenede Stater, 63141
- Siteman Cancer Center at West County Hospital
-
Farmington, Missouri, Forenede Stater, 63640
- Parkland Health Center - Farmington
-
Independence, Missouri, Forenede Stater, 64057
- Centerpoint Medical Center LLC
-
Jefferson City, Missouri, Forenede Stater, 65109
- Capital Region Southwest Campus
-
Joplin, Missouri, Forenede Stater, 64804
- Freeman Health System
-
Joplin, Missouri, Forenede Stater, 64804
- Mercy Hospital Joplin
-
Kansas City, Missouri, Forenede Stater, 64132
- Research Medical Center
-
Kansas City, Missouri, Forenede Stater, 64108
- Truman Medical Centers
-
Lee's Summit, Missouri, Forenede Stater, 64064
- University of Kansas Cancer Center - Lee's Summit
-
Rolla, Missouri, Forenede Stater, 65401
- Delbert Day Cancer Institute at PCRMC
-
Rolla, Missouri, Forenede Stater, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Saint Joseph, Missouri, Forenede Stater, 64506
- Heartland Regional Medical Center
-
Saint Louis, Missouri, Forenede Stater, 63110
- Washington University School of Medicine
-
Saint Louis, Missouri, Forenede Stater, 63131
- Missouri Baptist Medical Center
-
Saint Louis, Missouri, Forenede Stater, 63141
- Mercy Hospital Saint Louis
-
Saint Louis, Missouri, Forenede Stater, 63128
- Mercy Hospital South
-
Saint Louis, Missouri, Forenede Stater, 63129
- Siteman Cancer Center-South County
-
Saint Louis, Missouri, Forenede Stater, 63109
- Saint Louis Cancer and Breast Institute-South City
-
Saint Peters, Missouri, Forenede Stater, 63376
- Siteman Cancer Center at Saint Peters Hospital
-
Sainte Genevieve, Missouri, Forenede Stater, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, Forenede Stater, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Forenede Stater, 65804
- Mercy Hospital Springfield
-
Sullivan, Missouri, Forenede Stater, 63080
- Missouri Baptist Sullivan Hospital
-
Sunset Hills, Missouri, Forenede Stater, 63127
- BJC Outpatient Center at Sunset Hills
-
Washington, Missouri, Forenede Stater, 63090
- Mercy Hospital Washington
-
-
Montana
-
Anaconda, Montana, Forenede Stater, 59711
- Community Hospital of Anaconda
-
Billings, Montana, Forenede Stater, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, Forenede Stater, 59101
- Saint Vincent Healthcare
-
Billings, Montana, Forenede Stater, 59102
- Saint Vincent Frontier Cancer Center
-
Bozeman, Montana, Forenede Stater, 59715
- Bozeman Deaconess Hospital
-
Butte, Montana, Forenede Stater, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Forenede Stater, 59405
- Great Falls Clinic
-
Great Falls, Montana, Forenede Stater, 59405
- Benefis Healthcare- Sletten Cancer Institute
-
Helena, Montana, Forenede Stater, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, Forenede Stater, 59901
- Kalispell Regional Medical Center
-
Missoula, Montana, Forenede Stater, 59804
- Community Medical Hospital
-
Missoula, Montana, Forenede Stater, 59802
- Saint Patrick Hospital - Community Hospital
-
-
Nebraska
-
Grand Island, Nebraska, Forenede Stater, 68803
- CHI Health Saint Francis
-
Kearney, Nebraska, Forenede Stater, 68847
- CHI Health Good Samaritan
-
Kearney, Nebraska, Forenede Stater, 68845
- Heartland Hematology and Oncology
-
Lincoln, Nebraska, Forenede Stater, 68510
- Saint Elizabeth Regional Medical Center
-
Omaha, Nebraska, Forenede Stater, 68114
- Nebraska Methodist Hospital
-
Omaha, Nebraska, Forenede Stater, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Forenede Stater, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, Forenede Stater, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, Forenede Stater, 68131
- Creighton University Medical Center
-
Omaha, Nebraska, Forenede Stater, 68122
- Hematology and Oncology Consultants PC
-
Omaha, Nebraska, Forenede Stater, 68114
- Oncology Associates PC
-
Omaha, Nebraska, Forenede Stater, 68114
- Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
-
Papillion, Nebraska, Forenede Stater, 68046
- Midlands Community Hospital
-
-
Nevada
-
Carson City, Nevada, Forenede Stater, 89703
- Carson Tahoe Regional Medical Center
-
Henderson, Nevada, Forenede Stater, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Forenede Stater, 89052
- OptumCare Cancer Care at Seven Hills
-
Henderson, Nevada, Forenede Stater, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, Forenede Stater, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, Forenede Stater, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, Forenede Stater, 89074
- GenesisCare USA - Henderson
-
Henderson, Nevada, Forenede Stater, 89052
- Comprehensive Cancer Centers of Nevada-Horizon Ridge
-
Henderson, Nevada, Forenede Stater, 89074
- Las Vegas Urology - Green Valley
-
Henderson, Nevada, Forenede Stater, 89074
- Las Vegas Urology - Pebble
-
Henderson, Nevada, Forenede Stater, 89074
- Urology Specialists of Nevada - Green Valley
-
Las Vegas, Nevada, Forenede Stater, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, Forenede Stater, 89109
- Sunrise Hospital and Medical Center
-
Las Vegas, Nevada, Forenede Stater, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, Forenede Stater, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Forenede Stater, 89109
- GenesisCare USA - Las Vegas
-
Las Vegas, Nevada, Forenede Stater, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Forenede Stater, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Forenede Stater, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, Forenede Stater, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, Forenede Stater, 89144
- Comprehensive Cancer Centers of Nevada - Town Center
-
Las Vegas, Nevada, Forenede Stater, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Forenede Stater, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Forenede Stater, 89148
- OptumCare Cancer Care at Fort Apache
-
Las Vegas, Nevada, Forenede Stater, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Forenede Stater, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, Forenede Stater, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, Forenede Stater, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, Forenede Stater, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, Forenede Stater, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, Forenede Stater, 89128
- GenesisCare USA - Vegas Tenaya
-
Las Vegas, Nevada, Forenede Stater, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, Forenede Stater, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, Forenede Stater, 89148
- GenesisCare USA - Fort Apache
-
Las Vegas, Nevada, Forenede Stater, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, Forenede Stater, 89128
- Ann M Wierman MD LTD
-
Las Vegas, Nevada, Forenede Stater, 89074
- Las Vegas Urology - Pecos
-
Las Vegas, Nevada, Forenede Stater, 89102
- Desert West Surgery
-
Las Vegas, Nevada, Forenede Stater, 89103
- Hope Cancer Care of Nevada
-
Las Vegas, Nevada, Forenede Stater, 89106
- Urology Specialists of Nevada - Central
-
Las Vegas, Nevada, Forenede Stater, 89113
- Las Vegas Prostate Cancer Center
-
Las Vegas, Nevada, Forenede Stater, 89113
- Las Vegas Urology - Sunset
-
Las Vegas, Nevada, Forenede Stater, 89128
- Las Vegas Urology - Cathedral Rock
-
Las Vegas, Nevada, Forenede Stater, 89128
- Las Vegas Urology - Smoke Ranch
-
Las Vegas, Nevada, Forenede Stater, 89128
- Urology Specialists of Nevada - Northwest
-
Las Vegas, Nevada, Forenede Stater, 89169
- University Cancer Center
-
Las Vegas, Nevada, Forenede Stater, 89113
- Urology Specialists of Nevada - Southwest
-
Pahrump, Nevada, Forenede Stater, 89048
- Hope Cancer Care of Nevada-Pahrump
-
Reno, Nevada, Forenede Stater, 89502
- Renown Regional Medical Center
-
Reno, Nevada, Forenede Stater, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, Forenede Stater, 89509
- Radiation Oncology Associates
-
-
New Hampshire
-
Lebanon, New Hampshire, Forenede Stater, 03756
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
-
New Jersey
-
Hackensack, New Jersey, Forenede Stater, 07601
- Hackensack University Medical Center
-
Morristown, New Jersey, Forenede Stater, 07960
- Morristown Medical Center
-
Summit, New Jersey, Forenede Stater, 07902
- Overlook Hospital
-
-
New Mexico
-
Albuquerque, New Mexico, Forenede Stater, 87102
- University of New Mexico Cancer Center
-
Albuquerque, New Mexico, Forenede Stater, 87109
- New Mexico Oncology Hematology Consultants
-
-
New York
-
Bay Shore, New York, Forenede Stater, 11706
- Northwell Health Imbert Cancer Center
-
Buffalo, New York, Forenede Stater, 14263
- Roswell Park Cancer Institute
-
Cooperstown, New York, Forenede Stater, 13326
- Mary Imogene Bassett Hospital
-
Glens Falls, New York, Forenede Stater, 12801
- Glens Falls Hospital
-
Lake Success, New York, Forenede Stater, 11042
- Northwell Health/Center for Advanced Medicine
-
Middletown, New York, Forenede Stater, 10940
- Garnet Health Medical Center
-
Rochester, New York, Forenede Stater, 14642
- University of Rochester
-
Sleepy Hollow, New York, Forenede Stater, 10591
- Phelps Memorial Hospital Center
-
Syracuse, New York, Forenede Stater, 13210
- State University of New York Upstate Medical University
-
-
North Carolina
-
Charlotte, North Carolina, Forenede Stater, 28203
- Carolinas Medical Center/Levine Cancer Institute
-
Clemmons, North Carolina, Forenede Stater, 27012
- Wake Forest University at Clemmons
-
Concord, North Carolina, Forenede Stater, 28025
- Atrium Health Cabarrus/LCI-Concord
-
Greenville, North Carolina, Forenede Stater, 27834
- East Carolina University
-
Hendersonville, North Carolina, Forenede Stater, 28791
- Margaret R Pardee Memorial Hospital
-
Statesville, North Carolina, Forenede Stater, 28677
- Wake Forest Baptist Health - Hematology Oncology - Statesville
-
Wilkesboro, North Carolina, Forenede Stater, 28659
- Wake Forest Baptist Health - Wilkes Medical Center
-
Winston-Salem, North Carolina, Forenede Stater, 27157
- Wake Forest University Health Sciences
-
-
North Dakota
-
Bismarck, North Dakota, Forenede Stater, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, Forenede Stater, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, Forenede Stater, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, Forenede Stater, 58122
- Sanford Broadway Medical Center
-
Fargo, North Dakota, Forenede Stater, 58103
- Sanford South University Medical Center
-
Fargo, North Dakota, Forenede Stater, 58104
- Sanford Medical Center Fargo
-
Jamestown, North Dakota, Forenede Stater, 58401
- Essentia Health - Jamestown Clinic
-
-
Ohio
-
Beachwood, Ohio, Forenede Stater, 44122
- UHHS-Chagrin Highlands Medical Center
-
Beavercreek, Ohio, Forenede Stater, 45431
- Indu and Raj Soin Medical Center
-
Belpre, Ohio, Forenede Stater, 45714
- Strecker Cancer Center-Belpre
-
Boardman, Ohio, Forenede Stater, 44512
- Saint Elizabeth Boardman Hospital
-
Canton, Ohio, Forenede Stater, 44708
- Cleveland Clinic Mercy Hospital
-
Canton, Ohio, Forenede Stater, 44708
- Mercy Hematology and Oncology Associates Inc
-
Centerville, Ohio, Forenede Stater, 45459
- Miami Valley Hospital South
-
Centerville, Ohio, Forenede Stater, 45459
- Dayton Physicians LLC-Miami Valley South
-
Chardon, Ohio, Forenede Stater, 44024
- Geauga Hospital
-
Chillicothe, Ohio, Forenede Stater, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, Forenede Stater, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati, Ohio, Forenede Stater, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, Forenede Stater, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, Forenede Stater, 45236
- Oncology Hematology Care Inc-Kenwood
-
Cincinnati, Ohio, Forenede Stater, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, Forenede Stater, 45255
- TriHealth Cancer Institute-Anderson
-
Cleveland, Ohio, Forenede Stater, 44106
- Case Western Reserve University
-
Cleveland, Ohio, Forenede Stater, 44109
- MetroHealth Medical Center
-
Columbus, Ohio, Forenede Stater, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, Forenede Stater, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, Forenede Stater, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Forenede Stater, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, Forenede Stater, 43228
- Doctors Hospital
-
Columbus, Ohio, Forenede Stater, 43213
- Mount Carmel East Hospital
-
Columbus, Ohio, Forenede Stater, 43215
- Grant Medical Center
-
Columbus, Ohio, Forenede Stater, 43222
- Mount Carmel Health Center West
-
Dayton, Ohio, Forenede Stater, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, Forenede Stater, 45409
- Miami Valley Hospital
-
Dayton, Ohio, Forenede Stater, 45415
- Dayton Physician LLC-Miami Valley Hospital North
-
Dayton, Ohio, Forenede Stater, 45415
- Miami Valley Hospital North
-
Delaware, Ohio, Forenede Stater, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, Forenede Stater, 43015
- Grady Memorial Hospital
-
Dublin, Ohio, Forenede Stater, 43016
- Dublin Methodist Hospital
-
Dublin, Ohio, Forenede Stater, 43016
- Columbus Oncology and Hematology Associates
-
Findlay, Ohio, Forenede Stater, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, Forenede Stater, 45840
- Armes Family Cancer Center
-
Findlay, Ohio, Forenede Stater, 45840
- Orion Cancer Care
-
Franklin, Ohio, Forenede Stater, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Franklin, Ohio, Forenede Stater, 45005
- Dayton Physicians LLC-Atrium
-
Gahanna, Ohio, Forenede Stater, 43230
- Central Ohio Breast and Endocrine Surgery
-
Greenville, Ohio, Forenede Stater, 45331
- Wayne Hospital
-
Greenville, Ohio, Forenede Stater, 45331
- Dayton Physicians LLC-Wayne
-
Grove City, Ohio, Forenede Stater, 43123
- Mount Carmel Grove City Hospital
-
Kettering, Ohio, Forenede Stater, 45429
- Kettering Medical Center
-
Kettering, Ohio, Forenede Stater, 45409
- Greater Dayton Cancer Center
-
Kettering, Ohio, Forenede Stater, 45420
- First Dayton Cancer Care
-
Lancaster, Ohio, Forenede Stater, 43130
- Fairfield Medical Center
-
Lima, Ohio, Forenede Stater, 45801
- Saint Rita's Medical Center
-
Mansfield, Ohio, Forenede Stater, 44903
- OhioHealth Mansfield Hospital
-
Marietta, Ohio, Forenede Stater, 45750
- Marietta Memorial Hospital
-
Marion, Ohio, Forenede Stater, 43302
- OhioHealth Marion General Hospital
-
Mentor, Ohio, Forenede Stater, 44060
- UH Seidman Cancer Center at Lake Health Mentor Campus
-
Middleburg Heights, Ohio, Forenede Stater, 44130
- UH Seidman Cancer Center at Southwest General Hospital
-
Mount Vernon, Ohio, Forenede Stater, 43050
- Knox Community Hospital
-
New Albany, Ohio, Forenede Stater, 43054
- Mount Carmel New Albany Surgical Hospital
-
Newark, Ohio, Forenede Stater, 43055
- Licking Memorial Hospital
-
Newark, Ohio, Forenede Stater, 43055
- Newark Radiation Oncology
-
Parma, Ohio, Forenede Stater, 44129
- University Hospitals Parma Medical Center
-
Perrysburg, Ohio, Forenede Stater, 43551
- Mercy Health Perrysburg Cancer Center
-
Portsmouth, Ohio, Forenede Stater, 45662
- Southern Ohio Medical Center
-
Ravenna, Ohio, Forenede Stater, 44266
- University Hospitals Portage Medical Center
-
Sandusky, Ohio, Forenede Stater, 44870
- UH Seidman Cancer Center at Firelands Regional Medical Center
-
Springfield, Ohio, Forenede Stater, 45505
- Springfield Regional Medical Center
-
Springfield, Ohio, Forenede Stater, 45504
- Springfield Regional Cancer Center
-
Toledo, Ohio, Forenede Stater, 43608
- Saint Vincent Mercy Medical Center
-
Toledo, Ohio, Forenede Stater, 43623
- Mercy Health - Saint Anne Hospital
-
Troy, Ohio, Forenede Stater, 45373
- Upper Valley Medical Center
-
Troy, Ohio, Forenede Stater, 45373
- Dayton Physicians LLC - Troy
-
Wadsworth, Ohio, Forenede Stater, 44281
- University Hospitals Sharon Health Center
-
Warren, Ohio, Forenede Stater, 44484
- Saint Joseph Warren Hospital
-
West Chester, Ohio, Forenede Stater, 45069
- University of Cincinnati Cancer Center-West Chester
-
Westerville, Ohio, Forenede Stater, 43081
- Saint Ann's Hospital
-
Westlake, Ohio, Forenede Stater, 44145
- UH Seidman Cancer Center at Saint John Medical Center
-
Youngstown, Ohio, Forenede Stater, 44501
- Saint Elizabeth Youngstown Hospital
-
Zanesville, Ohio, Forenede Stater, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, Forenede Stater, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, Forenede Stater, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, Forenede Stater, 73120
- Mercy Hospital Oklahoma City
-
Tulsa, Oklahoma, Forenede Stater, 74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
-
Oregon
-
Baker City, Oregon, Forenede Stater, 97814
- Saint Alphonsus Medical Center-Baker City
-
Bend, Oregon, Forenede Stater, 97701
- Saint Charles Health System
-
Clackamas, Oregon, Forenede Stater, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, Forenede Stater, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, Forenede Stater, 97420
- Bay Area Hospital
-
Newberg, Oregon, Forenede Stater, 97132
- Providence Newberg Medical Center
-
Ontario, Oregon, Forenede Stater, 97914
- Saint Alphonsus Medical Center-Ontario
-
Portland, Oregon, Forenede Stater, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Forenede Stater, 97225
- Providence Saint Vincent Medical Center
-
Portland, Oregon, Forenede Stater, 97239
- Portland VA Medical Center
-
Redmond, Oregon, Forenede Stater, 97756
- Saint Charles Health System-Redmond
-
-
Pennsylvania
-
Allentown, Pennsylvania, Forenede Stater, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, Forenede Stater, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Chambersburg, Pennsylvania, Forenede Stater, 17201
- Chambersburg Hospital
-
Danville, Pennsylvania, Forenede Stater, 17822
- Geisinger Medical Center
-
East Stroudsburg, Pennsylvania, Forenede Stater, 18301
- Pocono Medical Center
-
Ephrata, Pennsylvania, Forenede Stater, 17522
- Ephrata Cancer Center
-
Ephrata, Pennsylvania, Forenede Stater, 17522
- Ephrata Community Hospital
-
Gettysburg, Pennsylvania, Forenede Stater, 17325
- Adams Cancer Center
-
Hanover, Pennsylvania, Forenede Stater, 17331
- Cherry Tree Cancer Center
-
Hazleton, Pennsylvania, Forenede Stater, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hazleton, Pennsylvania, Forenede Stater, 18201
- Lehigh Valley Hospital-Hazleton
-
Lebanon, Pennsylvania, Forenede Stater, 17042
- Sechler Family Cancer Center
-
Lewisburg, Pennsylvania, Forenede Stater, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, Forenede Stater, 17044
- Lewistown Hospital
-
Philadelphia, Pennsylvania, Forenede Stater, 19107
- Thomas Jefferson University Hospital
-
Pottsville, Pennsylvania, Forenede Stater, 17901
- Geisinger Cancer Services-Pottsville
-
Scranton, Pennsylvania, Forenede Stater, 18510
- Community Medical Center
-
Selinsgrove, Pennsylvania, Forenede Stater, 17870
- Geisinger Medical Oncology-Selinsgrove
-
State College, Pennsylvania, Forenede Stater, 16801
- Geisinger Medical Group
-
West Reading, Pennsylvania, Forenede Stater, 19611
- Reading Hospital
-
Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Willow Grove, Pennsylvania, Forenede Stater, 19090
- Asplundh Cancer Pavilion
-
York, Pennsylvania, Forenede Stater, 17403
- WellSpan Health-York Cancer Center
-
York, Pennsylvania, Forenede Stater, 17403
- WellSpan Health-York Hospital
-
-
South Carolina
-
Charleston, South Carolina, Forenede Stater, 29425
- Medical University of South Carolina
-
Greenville, South Carolina, Forenede Stater, 29607
- Saint Francis Cancer Center
-
Greenville, South Carolina, Forenede Stater, 29601
- Saint Francis Hospital
-
-
South Dakota
-
Sioux Falls, South Dakota, Forenede Stater, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Forenede Stater, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Chattanooga, Tennessee, Forenede Stater, 37404
- Memorial Hospital
-
Collierville, Tennessee, Forenede Stater, 38017
- Baptist Memorial Hospital and Cancer Center-Collierville
-
Franklin, Tennessee, Forenede Stater, 37067
- Vanderbilt-Ingram Cancer Center Cool Springs
-
Hixson, Tennessee, Forenede Stater, 37343
- Pulmonary Medicine Center of Chattanooga-Hixson
-
Knoxville, Tennessee, Forenede Stater, 37920
- University of Tennessee - Knoxville
-
Memphis, Tennessee, Forenede Stater, 38120
- Baptist Memorial Hospital and Cancer Center-Memphis
-
Nashville, Tennessee, Forenede Stater, 37232
- Vanderbilt University/Ingram Cancer Center
-
Nashville, Tennessee, Forenede Stater, 37204
- Vanderbilt Breast Center at One Hundred Oaks
-
Ooltewah, Tennessee, Forenede Stater, 37363
- Memorial GYN Plus
-
-
Texas
-
Abilene, Texas, Forenede Stater, 79601
- Hendrick Medical Center
-
Amarillo, Texas, Forenede Stater, 79106
- The Don and Sybil Harrington Cancer Center
-
Bryan, Texas, Forenede Stater, 77802
- Saint Joseph Regional Cancer Center
-
Houston, Texas, Forenede Stater, 77030
- M D Anderson Cancer Center
-
Houston, Texas, Forenede Stater, 77030
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
-
Houston, Texas, Forenede Stater, 77030
- Ben Taub General Hospital
-
-
Utah
-
American Fork, Utah, Forenede Stater, 84003
- American Fork Hospital / Huntsman Intermountain Cancer Center
-
Cedar City, Utah, Forenede Stater, 84720
- Sandra L Maxwell Cancer Center
-
Logan, Utah, Forenede Stater, 84321
- Logan Regional Hospital
-
Murray, Utah, Forenede Stater, 84107
- Intermountain Medical Center
-
Ogden, Utah, Forenede Stater, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, Forenede Stater, 84604
- Utah Valley Regional Medical Center
-
Riverton, Utah, Forenede Stater, 84065
- Riverton Hospital
-
Saint George, Utah, Forenede Stater, 84770
- Saint George Regional Medical Center
-
Salt Lake City, Utah, Forenede Stater, 84112
- Huntsman Cancer Institute/University of Utah
-
Salt Lake City, Utah, Forenede Stater, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, Forenede Stater, 84143
- LDS Hospital
-
-
Vermont
-
Berlin, Vermont, Forenede Stater, 05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington, Vermont, Forenede Stater, 05401
- University of Vermont Medical Center
-
Burlington, Vermont, Forenede Stater, 05405
- University of Vermont and State Agricultural College
-
-
Virginia
-
Richmond, Virginia, Forenede Stater, 23235
- VCU Massey Cancer Center at Stony Point
-
Richmond, Virginia, Forenede Stater, 23298
- Virginia Commonwealth University/Massey Cancer Center
-
Winchester, Virginia, Forenede Stater, 22601
- Shenandoah Oncology PC
-
-
Washington
-
Aberdeen, Washington, Forenede Stater, 98520
- Providence Regional Cancer System-Aberdeen
-
Auburn, Washington, Forenede Stater, 98001
- MultiCare Auburn Medical Center
-
Bellevue, Washington, Forenede Stater, 98004
- Overlake Medical Center
-
Bellingham, Washington, Forenede Stater, 98225
- PeaceHealth Saint Joseph Medical Center
-
Bremerton, Washington, Forenede Stater, 98310
- Harrison HealthPartners Hematology and Oncology-Bremerton
-
Bremerton, Washington, Forenede Stater, 98310
- Harrison Medical Center
-
Burien, Washington, Forenede Stater, 98166
- Highline Medical Center-Main Campus
-
Centralia, Washington, Forenede Stater, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, Forenede Stater, 98026
- Swedish Cancer Institute-Edmonds
-
Enumclaw, Washington, Forenede Stater, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, Forenede Stater, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, Forenede Stater, 98003
- Saint Francis Hospital
-
Gig Harbor, Washington, Forenede Stater, 98335
- MultiCare Gig Harbor Medical Park
-
Issaquah, Washington, Forenede Stater, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, Forenede Stater, 99336
- Kadlec Clinic Hematology and Oncology
-
Lacey, Washington, Forenede Stater, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, Forenede Stater, 98499
- Saint Clare Hospital
-
Longview, Washington, Forenede Stater, 98632
- PeaceHealth Saint John Medical Center
-
Port Townsend, Washington, Forenede Stater, 98368
- Jefferson Healthcare
-
Poulsbo, Washington, Forenede Stater, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Puyallup, Washington, Forenede Stater, 98372
- MultiCare Good Samaritan Hospital
-
Renton, Washington, Forenede Stater, 98055
- Valley Medical Center
-
Seattle, Washington, Forenede Stater, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, Forenede Stater, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, Forenede Stater, 98112
- Kaiser Permanente Washington
-
Seattle, Washington, Forenede Stater, 98104
- Pacific Gynecology Specialists
-
Seattle, Washington, Forenede Stater, 98122-5711
- Swedish Medical Center-Cherry Hill
-
Sedro-Woolley, Washington, Forenede Stater, 98284
- PeaceHealth United General Medical Center
-
Shelton, Washington, Forenede Stater, 98584
- Providence Regional Cancer System-Shelton
-
Spokane, Washington, Forenede Stater, 99204
- MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
-
Spokane, Washington, Forenede Stater, 99218
- MultiCare Deaconess Cancer and Blood Specialty Center - North
-
Spokane Valley, Washington, Forenede Stater, 99216
- MultiCare Deaconess Cancer and Blood Specialty Center - Valley
-
Tacoma, Washington, Forenede Stater, 98405
- Mary Bridge Children's Hospital and Health Center
-
Tacoma, Washington, Forenede Stater, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, Forenede Stater, 98405
- MultiCare Tacoma General Hospital
-
Tacoma, Washington, Forenede Stater, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Vancouver, Washington, Forenede Stater, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, Forenede Stater, 99362
- Providence Saint Mary Regional Cancer Center
-
Yakima, Washington, Forenede Stater, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
Yelm, Washington, Forenede Stater, 98597
- Providence Regional Cancer System-Yelm
-
-
Wisconsin
-
Antigo, Wisconsin, Forenede Stater, 54409
- Langlade Hospital and Cancer Center
-
Appleton, Wisconsin, Forenede Stater, 54915
- Ascension Saint Elizabeth Hospital
-
Ashland, Wisconsin, Forenede Stater, 54806
- Duluth Clinic Ashland
-
Ashland, Wisconsin, Forenede Stater, 54806
- Northwest Wisconsin Cancer Center
-
Brookfield, Wisconsin, Forenede Stater, 53045
- Ascension Southeast Wisconsin Hospital - Elmbrook Campus
-
Burlington, Wisconsin, Forenede Stater, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Chilton, Wisconsin, Forenede Stater, 53014
- Ascension Calumet Hospital
-
Chippewa Falls, Wisconsin, Forenede Stater, 54729
- Marshfield Clinic-Chippewa Center
-
Eau Claire, Wisconsin, Forenede Stater, 54701
- Marshfield Medical Center-EC Cancer Center
-
Fond Du Lac, Wisconsin, Forenede Stater, 54937
- Aurora Health Center-Fond du Lac
-
Franklin, Wisconsin, Forenede Stater, 53132
- Ascension Saint Francis - Reiman Cancer Center
-
Franklin, Wisconsin, Forenede Stater, 53132
- Ascension Southeast Wisconsin Hospital - Franklin
-
Germantown, Wisconsin, Forenede Stater, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, Forenede Stater, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, Forenede Stater, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, Forenede Stater, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, Forenede Stater, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Hayward, Wisconsin, Forenede Stater, 54843
- Essentia Health-Hayward Clinic
-
Kenosha, Wisconsin, Forenede Stater, 53142
- Aurora Cancer Care-Kenosha South
-
Ladysmith, Wisconsin, Forenede Stater, 54848
- Marshfield Clinic - Ladysmith Center
-
Manitowoc, Wisconsin, Forenede Stater, 54221
- Holy Family Memorial Hospital
-
Marinette, Wisconsin, Forenede Stater, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marinette, Wisconsin, Forenede Stater, 54143
- Saint Vincent Hospital Cancer Center at Marinette
-
Marshfield, Wisconsin, Forenede Stater, 54449
- Marshfield Medical Center-Marshfield
-
Medford, Wisconsin, Forenede Stater, 54451
- Aspirus Medford Hospital
-
Mequon, Wisconsin, Forenede Stater, 53097
- Ascension Columbia Saint Mary's Hospital Ozaukee
-
Milwaukee, Wisconsin, Forenede Stater, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, Forenede Stater, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, Forenede Stater, 53233
- Aurora Sinai Medical Center
-
Milwaukee, Wisconsin, Forenede Stater, 53210
- Ascension Southeast Wisconsin Hospital - Saint Joseph Campus
-
Milwaukee, Wisconsin, Forenede Stater, 53211
- Ascension Columbia Saint Mary's Hospital - Milwaukee
-
Milwaukee, Wisconsin, Forenede Stater, 53215
- Ascension Saint Francis Hospital
-
Minocqua, Wisconsin, Forenede Stater, 54548
- Marshfield Clinic-Minocqua Center
-
Mukwonago, Wisconsin, Forenede Stater, 53149
- ProHealth D N Greenwald Center
-
New Richmond, Wisconsin, Forenede Stater, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, Forenede Stater, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oconto Falls, Wisconsin, Forenede Stater, 54154
- Saint Vincent Hospital Cancer Center at Oconto Falls
-
Oshkosh, Wisconsin, Forenede Stater, 54904
- Ascension Mercy Hospital
-
Oshkosh, Wisconsin, Forenede Stater, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, Forenede Stater, 53406
- Aurora Cancer Care-Racine
-
Racine, Wisconsin, Forenede Stater, 53405
- Ascension All Saints Hospital
-
Rhinelander, Wisconsin, Forenede Stater, 54501
- Ascension Saint Mary's Hospital
-
Rice Lake, Wisconsin, Forenede Stater, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, Forenede Stater, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Sheboygan, Wisconsin, Forenede Stater, 53081
- HSHS Saint Nicholas Hospital
-
Spooner, Wisconsin, Forenede Stater, 54801
- Essentia Health-Spooner Clinic
-
Stevens Point, Wisconsin, Forenede Stater, 54481
- Ascension Saint Michael's Hospital
-
Stevens Point, Wisconsin, Forenede Stater, 54482
- Marshfield Medical Center-River Region at Stevens Point
-
Sturgeon Bay, Wisconsin, Forenede Stater, 54235-1495
- Saint Vincent Hospital Cancer Center at Sturgeon Bay
-
Summit, Wisconsin, Forenede Stater, 53066
- Aurora Medical Center in Summit
-
Superior, Wisconsin, Forenede Stater, 54880
- Essentia Health Saint Mary's Hospital - Superior
-
Two Rivers, Wisconsin, Forenede Stater, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, Forenede Stater, 53188
- UW Cancer Center at ProHealth Care
-
Waukesha, Wisconsin, Forenede Stater, 53188
- ProHealth Waukesha Memorial Hospital
-
Wausau, Wisconsin, Forenede Stater, 54401
- Aspirus Regional Cancer Center
-
Wausau, Wisconsin, Forenede Stater, 54401
- Marshfield Clinic-Wausau Center
-
Wauwatosa, Wisconsin, Forenede Stater, 53226
- Aurora Cancer Care-Milwaukee West
-
Wauwatosa, Wisconsin, Forenede Stater, 53226
- Ascension Medical Group Southeast Wisconsin - Mayfair Road
-
West Allis, Wisconsin, Forenede Stater, 53227
- Aurora West Allis Medical Center
-
Weston, Wisconsin, Forenede Stater, 54476
- Marshfield Medical Center - Weston
-
Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
- Aspirus Cancer Care - Wisconsin Rapids
-
Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
-
Wyoming
-
Cheyenne, Wyoming, Forenede Stater, 82001
- Cheyenne Regional Medical Center-West
-
Cody, Wyoming, Forenede Stater, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, Forenede Stater, 82801
- Welch Cancer Center
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
18 år og ældre (Voksen, Ældre voksen)
Tager imod sunde frivillige
Ingen
Beskrivelse
Inklusionskriterier:
- TRIN 1 REGISTRERING (RANDOMISERING): Patienter skal have klinisk påviselig fase III (klinisk påviselig N1b, N1c, N2b, N2c, N3b og N3c) eller fase IV resektabel melanom. Patienter med melanom af slimhinde- eller akral oprindelse er kvalificerede. Patienter med melanom af uveal oprindelse er ikke kvalificerede. Patienter med en historie med hjernemetastaser er ikke kvalificerede. Klinisk påviselig er defineret som sygdom, der er synlig og målbar via fysisk undersøgelse eller røntgenbillede.
- TRIN 1 REGISTRERING (RANDOMISERING): Patienter er kvalificerede til dette forsøg enten ved den første præsentation af deres melanom eller på tidspunktet for den første detekterede nodal, satellit/in-transit, fjernmetastaser eller tilbagevendende sygdom i tidligere lymfadenektomibassin eller fjerntliggende sted. Nodal, satellit/in-transit metastaser, fjernmetastaser eller sygdom i et tidligere komplet lymfadenektomibassin skal være bekræftet histologisk af hæmatoxylin (H) & eosin (E) farvede objektglas.
- TRIN 1 REGISTRERING (RANDOMISERING): Patienter med multiple regionale knudebassininvolvering er kvalificerede. Grov eller mikroskopisk ekstrakapsulær nodal forlængelse er tilladt.
- TRIN 1 REGISTRERING (RANDOMISERING): Patienter skal have histologisk bevist stadium IIIB eller højere. Dette ville indebære patologisk bekræftelse ud over den primære eller indledende diagnose af melanom, der involverer finnålsaspirationscytologi eller biopsibekræftelse af et hvilket som helst N-kategori eller M-kategori resekterbart sted.
- TRIN 1 REGISTRERING (RANDOMISERING): Patienter kan have modtaget tidligere strålebehandling, herunder efter forudgående kirurgisk resektion. Alle uønskede hændelser forbundet med tidligere operation og strålebehandling skal være forsvundet til =< grad 1 før randomisering.
- TRIN 1 REGISTRERING (RANDOMISERING): Patienter skal være >= 18 år
TRIN 1 REGISTRERING (RANDOMISERING): Alle patienter skal have sygdomsstatus dokumenteret ved en fuldstændig fysisk undersøgelse og billeddiagnostiske undersøgelser inden for 42 dage før randomisering. Billeddiagnostiske undersøgelser skal omfatte en CT af brystet, maven og bækkenet med intravenøs kontrast (medmindre det er kontraindiceret). For patienter med melanom, der opstår fra hoved og hals, kræves dedikeret nakkebilleddannelse (CT med intravenøs kontrast). Hvis patienten har ukendt primær med sygdom i aksillen, kræves nakkebilleddannelse CT-billeddannelse skal foretages med intravenøs kontrast, hvis der ikke er kontraindikationer for det. Ekstremitetsmelanomer skal afbildes ved hjælp af CT med intravenøs kontrast eller MR med og uden gadolinium
- Bemærk: PET-CT-scanninger er IKKE acceptable for at fastslå berettigelse. Ikke-jodholdige CT-scanninger, som er en del af almindelige PET-CT-billeddannelsesprotokoller, giver ikke kontrast til områder, der er svære at konstatere, såsom nakke og lever, og giver ikke nok CT-detaljer til at udføre passende RECIST 1.1-målinger. Som sådan anses en PET-CT med CT-billeder uden kontrast eller ikke-diagnostisk kvalitet CT-billeder for utilstrækkelige til påvisning af melanom.
- TRIN 1 REGISTRERING (RANDOMISERING): Alle patienter skal have en CT eller magnetisk resonansbilleddannelse (MRI) af hjernen inden for 42 dage før randomisering. Hjernen CT eller MR skal udføres med intravenøs kontrast (medmindre kontraindiceret).
- TRIN 1 REGISTRERING (RANDOMISERING): Absolut neutrofiltal (ANC) >= 1.500/mikroliter (mcL) (inden for 42 dage før randomisering).
- TRIN 1 REGISTRERING (RANDOMISERING): Blodplader >= 100.000/mcL (inden for 42 dage før randomisering).
- TRIN 1 REGISTRERING (RANDOMISERING): Hæmoglobin >= 10 g/dL (inden for 42 dage før randomisering).
- TRIN 1 REGISTRERING (RANDOMISERING): Total bilirubin =< 1,5 x institutionel øvre normalgrænse (IULN) (undtagen patienter med Gilberts syndrom, som skal have en total bilirubin < 3,0 mg/dL) (inden for 42 dage før randomisering).
- TRIN 1 REGISTRERING (RANDOMISERING): Serumglutamin-oxaloeddikesyretransaminase (SGOT) (aspartataminotransferase [AST]) og serumglutamatpyruvattransaminase (SGPT) (alaninaminotransferase [ALT]) =< 2 x IULN (inden for 42 dage før randomisering) .
- TRIN 1 REGISTRERING (RANDOMISERING): Alkalisk fosfatase =< 2 x IULN (inden for 42 dage før randomisering).
- TRIN 1 REGISTRERING (RANDOMISERING): Patienter skal have udført lactatdehydrogenase (LDH) inden for 42 dage før randomisering.
- TRIN 1 REGISTRERING (RANDOMISERING): Patienter skal have tilstrækkelig nyrefunktion som dokumenteret ved beregnet kreatininclearance > 30 ml/min. Kreatininniveauet (mg/dL), der anvendes i beregningen, skal opnås inden for 42 dage før randomisering.
- TRIN 1 REGISTRERING (RANDOMISERING): Patienter skal have Zubrod præstationsstatus =< 2.
- TRIN 1 REGISTRERING (RANDOMISERING): Patienter, der vides at være positive med human immundefektvirus (HIV) er kvalificerede, hvis de opfylder følgende kriterier inden for 30 dage før randomisering: stabile og tilstrækkelige CD4-tal (>= 350 mm^3) og serum-hiv viral belastning på < 25.000 IE/ml. Patienter kan være tændt eller slukket for antiviral behandling, så længe de opfylder kriterierne for CD4-tælling.
- TRIN 1 REGISTRERING (RANDOMISERING): Tidligere malignitet er tilladt, forudsat at det ikke kræver samtidig behandling.
- TRIN 1 REGISTRERING (RANDOMISERING): Kvinder i den fødedygtige alder skal have en negativ urin- eller serumgraviditetstest inden for 28 dage før randomisering. Kvinder/mænd med reproduktionspotentiale skal have accepteret at bruge en effektiv præventionsmetode i løbet af undersøgelsen gennem 120 dage efter den sidste dosis af undersøgelsesmedicin. Hvis en kvinde bliver gravid eller har mistanke om, at hun er gravid, mens hun eller hendes partner deltager i denne undersøgelse, skal hun straks informere sin behandlende læge. En kvinde anses for at have "reproduktionspotentiale", hvis hun har haft menstruation på noget tidspunkt i de foregående 12 på hinanden følgende måneder. Ud over rutinepræventionsmetoder omfatter "effektiv prævention" også heteroseksuel cølibat og kirurgi beregnet til at forhindre graviditet (eller med en bivirkning af graviditetsforebyggelse) defineret som en hysterektomi, bilateral ooforektomi eller bilateral tubal ligering. Men hvis en tidligere cølibatpatient på noget tidspunkt vælger at blive heteroseksuelt aktiv i løbet af tidsperioden for brug af svangerskabsforebyggende foranstaltninger, der er beskrevet i protokollen, er han/hun ansvarlig for at påbegynde svangerskabsforebyggende foranstaltninger. Patienter må ikke være gravide eller ammende på grund af ukendte teratogene bivirkninger.
- TRIN 1 REGISTRERING (RANDOMISERING): Patienter skal anses for medicinsk egnede til at blive opereret af det behandlende medicinske/kirurgiske team.
- TRIN 1 REGISTRERING (RANDOMISERING): Patienter skal være villige til at indsende følgende kirurgiske prøver: enten alle vævsblokke fra den kirurgiske prøve eller to objektglas pr. blok ([1] hæmatoxylin og eosin [H&E] objektglas og [1] ufarvet objektglas ELLER [ 2] ufarvede objektglas, hvis H&E-farvede objektglas ikke kan leveres).
- TRIN 1 REGISTRERING (RANDOMISERING): Patienter skal tilbydes mulighed for at deltage i prøvebank.
- TRIN 1 REGISTRERING (RANDOMISERING): Patienterne skal informeres om undersøgelsens karakter af denne undersøgelse og skal underskrive og give skriftligt informeret samtykke til denne protokol i overensstemmelse med institutionelle og føderale retningslinjer.
- TRIN 1 REGISTRERING (RANDOMISERING): Som en del af Oncology Patient Enrollment Network (OPEN) randomiseringsprocessen oplyses den behandlende institutions identitet for at sikre, at den aktuelle (inden for 365 dage) datoen for institutionelle revisionsnævns godkendelse af denne undersøgelse er blevet lagt ind i systemet.
- TRIN 2 REGISTRERING (KIRURGI): Patienter randomiseret til arm 2 (neoadjuverende arm) skal være villige til at indsende væv for at bestemme patologisk respons uanset antallet af modtagne præoperative doser af pembrolizumab (MK-3475). Bestemmelse af patologisk respons kan ikke foretages på mindre end den fulde kirurgiske prøve.
- TRIN 2 REGISTRERING (KIRURGI): Patienter skal have sygdomsvurderinger med CT bryst/abdomen/bækken med IV kontrast, og hals CT med IV kontrast, hvis primært hoved- og hals melanom, udført inden for 42 dage (og højst 49 dage) før planlagt operationsdato. MR kombineret med ikke-kontrast CT er et acceptabelt alternativ for patienter med CT kontrastallergi, men billeddiagnostik skal omfatte hele kroppen.
- TRIN 2 REGISTRERING (KIRURGI): Patienter skal registrere sig til trin 2 inden for 17 dage før planlagt operationsdato.
TRIN 3 REGISTRERING (ADJUVANT BEHANDLING): Patienter skal have gennemgået en operation inden Trin 3 registrering. Trin 2-operationen skal have fuldstændig resekeret deres melanom.
- Patienter med grov positiv restsygdom efter operation kvalificeres ikke som sygdomsfri status, og derfor er sådanne patienter ikke berettiget til at registrere sig for adjuverende behandling.
- Patienter med mikroskopisk resterende sygdom (dvs. positive marginer) kan behandles med re-excision eller stråling, pr. steds skøn, for at gøre patienten sygdomsfri før registrering af adjuverende terapi.
- Sygdomsfri status skal dokumenteres ved en fuldstændig fysisk undersøgelse og røntgenundersøgelser inden for 42 dage før trin 3 registrering. Billeddiagnostiske undersøgelser skal omfatte en CT af brystet, maven og bækkenet (medmindre det er kontraindiceret). Ekstremitetsmelanomer skal afbildes ved hjælp af CT med intravenøs kontrast eller MR med og uden gadolinium. CT-billeddannelse skal udføres med intravenøs kontrast, hvis der ikke er kontraindikationer for det.
- For patienter med melanom, der opstår fra hoved og hals, er dedikeret nakkebilleddannelse (CT med IV-kontrast, medmindre kontraindiceret) påkrævet.
- Hvis patienten har haft ukendt primær med sygdom i aksillen, er halsbilleddannelse påkrævet for at sikre, at regionen er fri for kræft.
- Eventuelle andre klinisk indicerede billeddiagnostiske undersøgelser, hvis de udføres (f.eks. knoglescanning), må ikke vise tegn på sygdom.
- TRIN 3 REGISTRERING (ADJUVANT BEHANDLING): Patienter skal registreres til trin 3 højst 84 dage efter operationsdato.
- TRIN 3 REGISTRERING (ADJUVANT BEHANDLING): Patienter med R0 eller R1 resektioner skal have sygdomsfri status dokumenteret ved en fuldstændig fysisk undersøgelse og billeddiagnostiske undersøgelser inden for 42 dage før trin 3 registrering. Disse patienter skal have sygdomsvurderinger ved CT bryst/abdomen/bækken med IV kontrast, og hals CT med IV kontrast, hvis primært hoved- og hals melanom. MR kombineret med ikke-kontrast CT er et acceptabelt alternativ for patienter med CT kontrastallergi, men billeddiagnostik skal omfatte hele kroppen.
- TRIN 3 REGISTRERING (ADJUVANT BEHANDLING): Patienter med R2-resektioner er ikke kvalificerede til trin 3 og skal fjernes fra undersøgelsesbehandlingen
Ekskluderingskriterier:
- TRIN 1 REGISTRERING (RANDOMISERING): Patienter må ikke have modtaget tidligere neoadjuverende behandling for deres melanom. Patienter kan have modtaget tidligere ikke-immunterapi adjuverende terapi. Patienter må ikke have haft tidligere immunterapi, herunder, men ikke begrænset til ipilimumab, interferon alfa-2b, højdosis interleukin (IL)-2, pegyleret-interferon (PEG-IFN), anti-PD-1, anti-PD-L1 intra -tumor- eller vaccinebehandlinger. Patienter må ikke planlægge at modtage nogen af de forbudte behandlinger under behandlingsfaserne i undersøgelsen.
- TRIN 1 REGISTRERING (RANDOMISERING): Patienter må ikke planlægge at modtage anden biologisk behandling, hormonbehandling, anden kemoterapi, kirurgi, mens de er i protokolbehandling.
- TRIN 1 REGISTRERING (RANDOMISERING): Patienter må ikke have en historie med (ikke-infektiøs) pneumonitis, der krævede steroider eller aktuel pneumonitis.
- TRIN 1 REGISTRERING (RANDOMISERING): Patienter må ikke have en aktiv infektion, der kræver systemisk behandling.
- TRIN 1 REGISTRERING (RANDOMISERING): Patienter må ikke have aktiv autoimmun sygdom, der har krævet systemisk behandling i de sidste 2 år (dvs. med brug af sygdomsmodificerende midler, kortikosteroider eller immunsuppressive lægemidler). Substitutionsterapi (f.eks. thyroxin, insulin eller fysiologisk kortikosteroiderstatningsterapi for binyre- eller hypofyseinsufficiens osv.) betragtes ikke som en form for systemisk behandling.
TRIN 1 REGISTRERING (RANDOMISERING): Patienter må ikke have modtaget levende vacciner inden for 42 dage før randomisering. Eksempler på levende vacciner omfatter, men er ikke begrænset til, følgende: mæslinger, fåresyge, røde hunde, skoldkopper, helvedesild, gul feber, rabies, Bacillus Calmette-Guerin (BCG) og tyfus (oral) vaccine. Sæsoninfluenzavacciner til injektion er generelt dræbte virusvacciner og er tilladt; dog er intranasale influenzavacciner (f.eks. Flu-Mist) levende svækkede vacciner og er ikke tilladt.
- BEMÆRK: COVID-19-vaccinerne (tilgængelige i øjeblikket og dem, der er i pipelinen for FDA-nødbrugstilladelse eller FDA-godkendelse) indeholder ikke levende virus, og derfor påvirker eller udelukker COVID-19-vaccination ikke berettigelse til S1801-forsøget. For patienter, der har gennemgået lymfadenektomi, bør vacciner gives til en lem med et intakt lymfeknudebassin (Sentinel lymfeknudebiopsi i en lem er acceptabel). Vaccinen bør ikke administreres i en lem, der har gennemgået lymfadenektomi.
- TRIN 1 REGISTRERING (RANDOMISERING): Patienter må ikke have kendt aktiv hepatitis B virus (HBV) eller hepatitis C virus (HCV) infektion før randomisering. Bemærk: Ingen test for hepatitis B og hepatitis C er påkrævet, medmindre det er påbudt af den lokale sundhedsmyndighed.
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Eksperimentel: Arm I (adjuverende pembrolizumab)
Inden for 17 dage (helst inden for 14 dage) dage efter IV over 30 minutter på dag 1.
Behandlingen gentages hver 3. uge i 18 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet.
Patienterne gennemgår også opsamling af blod under hele undersøgelsen og MR eller CT under undersøgelsen.
|
Gennemgå indsamling af blod
Andre navne:
Gennemgå MR
Andre navne:
Gennemgå CT
Andre navne:
Givet IV
Andre navne:
Gennemgå operation
|
|
Aktiv komparator: Arm II (adjuverende og neoadjuverende pembrolizumab)
Patienterne får pembrolizumab IV over 30 minutter på dag 1 hver 3. uge i 3 cyklusser, hvorefter de skal opereres inden for 3 uger.
Inden for 84 dage får patienterne pembrolizumab IV over 30 minutter hver 3. uge i 15 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet.
Patienterne gennemgår også opsamling af blod under hele undersøgelsen og MR eller CT under undersøgelsen.
|
Gennemgå indsamling af blod
Andre navne:
Gennemgå MR
Andre navne:
Gennemgå CT
Andre navne:
Givet IV
Andre navne:
Gennemgå operation
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
To års begivenhedsfri overlevelsesrate
Tidsramme: 2 år
|
Hændelsesfri overlevelse (EFS) måles fra datoen for randomisering til datoen for den første: dokumentation for progression, der gør deltageren ude af stand til at modtage planlagt protokolkirurgi, off-protokol-terapi af en eller anden grund uden efterfølgende protokolkirurgi, manglende påbegyndelse af adjuverende terapi inden for 84 dage efter operation, tilbagefald efter operation eller død på grund af en hvilken som helst årsag.
Deltagere, der sidst er kendt for at være i live og begivenhedsfri, censureres på datoen for sidste kontakt.
Alle hændelser, der opstod før starten af adjuverende terapi, blev tildelt en hændelsesdato på 84 dage.
|
2 år
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Antal deltagere med grad 3 til 5 uønskede hændelser, der er relateret til undersøgelsesmedicin
Tidsramme: Varighed af behandling og opfølgning indtil tilbagefald, død eller 3,5 år efter randomisering.
|
Kun uønskede hændelser, der muligvis, sandsynligvis eller helt sikkert er relateret til undersøgelseslægemidlet, er rapporteret.
|
Varighed af behandling og opfølgning indtil tilbagefald, død eller 3,5 år efter randomisering.
|
|
To-års samlet overlevelsesrate
Tidsramme: 2 år
|
Samlet overlevelse (OS) måles fra dato for randomisering til dato for død på grund af enhver årsag.
Deltagere, der vides at være i live, censureres på datoen for sidste kontakt.
|
2 år
|
|
Svarprocent
Tidsramme: 2 år
|
På den neoadjuverende arm blev responsraten vurderet efter neoadjuverende terapi og før kirurgisk resektion.
Svarprocenten omfatter både fuldstændig respons (CR) og delvis respons (PR).
CR er defineret som fuldstændig forsvinden af alle mål- og ikke-mållæsioner, ingen nye læsioner og ingen sygdomsrelaterede symptomer.
PR er defineret som større end eller lig med 30 % fald under baseline af summen af alle passende diametre af alle målbare læsioner, ingen utvetydig progression eller ikke-målbar sygdom og ingen nye læsioner.
Den bedste svarprocent beregnes ud fra rækkefølgen af objektive statusser.
CR er defineret som to eller flere objektive statusser af CR med minimum fire ugers mellemrum dokumenteret før progression eller symptomatisk forværring.
PR er defineret som to eller flere objektive statusser af PR eller bedre med minimum fire ugers mellemrum dokumenteret før progression eller symptomatisk forværring, men ikke kvalificeret som CR.
|
2 år
|
|
Antal deltagere, der modtager operation
Tidsramme: 2,5 år
|
At bestemme antallet af deltagere på hver arm, der modtog operationen planlagt ved randomisering.
|
2,5 år
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Efterforskere
- Ledende efterforsker: Sapna P Patel, SWOG Cancer Research Network
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
15. februar 2019
Primær færdiggørelse (Faktiske)
1. september 2022
Studieafslutning (Anslået)
21. september 2024
Datoer for studieregistrering
Først indsendt
4. oktober 2018
Først indsendt, der opfyldte QC-kriterier
4. oktober 2018
Først opslået (Faktiske)
5. oktober 2018
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Anslået)
15. februar 2024
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
14. februar 2024
Sidst verificeret
1. september 2023
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
- Hudsygdomme
- Neoplasmer efter histologisk type
- Neoplasmer
- Neoplasmer efter sted
- Neuroektodermale tumorer
- Neoplasmer, kimceller og embryonale
- Neoplasmer, nervevæv
- Neuroendokrine tumorer
- Nevi og melanomer
- Melanom
- Neoplasmer i huden
- Molekylære mekanismer for farmakologisk virkning
- Antineoplastiske midler
- Antineoplastiske midler, immunologiske
- Immune Checkpoint-hæmmere
- Pembrolizumab
Andre undersøgelses-id-numre
- NCI-2018-02107 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
- U10CA180888 (U.S. NIH-bevilling/kontrakt)
- S1801 (Anden identifikator: CTEP)
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
Studerer et amerikansk FDA-reguleret lægemiddelprodukt
Ja
Studerer et amerikansk FDA-reguleret enhedsprodukt
Ingen
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
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