Denne side blev automatisk oversat, og nøjagtigheden af ​​oversættelsen er ikke garanteret. Der henvises til engelsk version for en kildetekst.

Effekt af Evolocumab hos patienter med høj kardiovaskulær risiko uden forudgående myokardieinfarkt eller slagtilfælde (VESALIUS-CV)

1. juni 2026 opdateret af: Amgen

En dobbeltblind, randomiseret, placebokontrolleret, multicenterundersøgelse til evaluering af Evolocumabs indvirkning på større kardiovaskulære hændelser hos patienter med høj kardiovaskulær risiko uden forudgående myokardieinfarkt eller slagtilfælde

Denne undersøgelse vil vurdere effekten af ​​at sænke low-density lipoprotein kolesterol (LDL-C) med evolocumab på større kardiovaskulære hændelser hos voksne uden forudgående myokardieinfarkt (MI) eller slagtilfælde, som har høj risiko for en kardiovaskulær hændelse.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

12301

Fase

  • Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Argentina
      • Corrientes, Argentina, W3400AMZ
        • Instituto de Cardiologia de Corrientes Juana Francisca Cabral
      • Córdoba, Argentina, X5003DCE
        • Instituto Medico DAMIC - Fundacion Rusculleda
      • Salta, Argentina, A4400ANW
        • Cordis Sa
      • San Juan, Argentina, J5400ARW
        • Clinica El Castaño
      • San Luis, Argentina, D5702JRS
        • Instituto Cardiovascular San Luis
      • Santa Fe, Argentina, S3000FWO
        • Centro de Investigaciones Clinicas del Litoral
    • Buenos Aires
      • Bahía Blanca, Buenos Aires, Argentina, B8000FTD
        • Instituto de Investigaciones Clínicas Bahia Blanca
      • CABA, Buenos Aires, Argentina, C1426ABP
        • Fundacion Respirar
      • CABA, Buenos Aires, Argentina, C1023AAB
        • STAT Research
      • CABA, Buenos Aires, Argentina, C1027AAP
        • CINME - Centro De Investigaciones Metabolicas
      • CABA, Buenos Aires, Argentina, C1119ACN
        • Ciprec - Centro de Investigacion y Prevencion Cardiovascular
      • CABA, Buenos Aires, Argentina, C1406BOA
        • Consultorio Medico Dr Litvak Bruno
      • CABA, Buenos Aires, Argentina, C1407GTN
        • Centro de Especialidades Medicas - Cemedic
      • CABA, Buenos Aires, Argentina, C1425AGC
        • Centro Medico Laura Maffei
      • CABA, Buenos Aires, Argentina, C1425BNG
        • Cardiología Palermo
      • CABA, Buenos Aires, Argentina, C1425DES
        • CEDIC - Centro de Investigacion Clinica
      • CABA, Buenos Aires, Argentina, C1426ABP
        • Centro Médico Dra de Salvo
      • Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1012AAR
        • Instituto de Investigaciones Metabólicas - IDIM
      • Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1093AAS
        • Hospital Universitario Fundacion Favaloro
      • Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1428ART
        • ICBA - Instituto Cardiovascular de Buenos Aires
      • Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1430CKE
        • Glenny Corp SA
      • Mar del Plata, Buenos Aires, Argentina, B7600FZN
        • Instituto de Investigaciones Clinicas Mar del Plata
      • Morón, Buenos Aires, Argentina, B1708EPE
        • Ciad - Consultorio Integral de Atencion al Diabetico
      • Ramos Mejía, Buenos Aires, Argentina, B1704ETD
        • DIM Clinica Privada
      • San Nicolás de los Arroyos, Buenos Aires, Argentina, B2900DMH
        • Instituto de Investigaciones Clinicas de San Nicolas
      • Zárate, Buenos Aires, Argentina, B2800DGH
        • Instituto de Investigaciones Clínicas Zárate
    • Córdoba Province
      • Córdoba, Córdoba Province, Argentina, 5000
        • Clinica Privada del Prado
      • Villa María, Córdoba Province, Argentina, X5900JKA
        • Clinica Fusavim Privada SRL
    • La Pampa Province
      • Santa Rosa, La Pampa Province, Argentina, 6300
        • Sanatorio Santa Rosa Srl
    • Santa Fe Province
      • Rosario, Santa Fe Province, Argentina, 2000
        • Instituto de Investigaciones Clínicas Rosario-Sanatorio Delta
      • Rosario, Santa Fe Province, Argentina, 2000
        • Sanatorio Plaza
    • Tucumán Province
      • San Miguel de Tucumán, Tucumán Province, Argentina, 4000
        • Centro Modelo de Cardiologia
      • San Miguel de Tucumán, Tucumán Province, Argentina, 4000
        • Clinical Mayo de Urgencias Medicas Cruz Blanca SRL
  • Australien
      • Woolloongabba, Australien, 4102
        • Dr Heart Pty Ltd
    • Australian Capital Territory
      • Garran, Australian Capital Territory, Australien, 2605
        • Canberra Hospital
    • New South Wales
      • Camperdown, New South Wales, Australien, 2050
        • Royal Prince Alfred Hospital
      • Liverpool, New South Wales, Australien, 2170
        • Liverpool Hospital
      • Maroubra, New South Wales, Australien, 2035
        • Australian Clinical Research Network
    • Queensland
      • Auchenflower, Queensland, Australien, 4066
        • Heartcare Partners
      • Bundaberg, Queensland, Australien, 4670
        • Bundaberg Cardiology
      • Fortitude Valley, Queensland, Australien, 4006
        • Holdsworth House Medical Brisbane
      • Milton, Queensland, Australien, 4064
        • Core Research Group Pty Ltd
    • South Australia
      • Adelaide, South Australia, Australien, 5000
        • Royal Adelaide Hospital
      • Adelaide, South Australia, Australien, 5000
        • Heart and Vascular Research
      • Ashford, South Australia, Australien, 5035
        • SA Heart
      • Leabrook, South Australia, Australien, 5068
        • Adelaide Cardiology Practice - Leabrook Clinic
    • Tasmania
      • Hobart, Tasmania, Australien, 7000
        • Royal Hobart Hospital
    • Victoria
      • Berwick, Victoria, Australien, 3806
        • HeartCare Victoria - Berwick
      • Clayton, Victoria, Australien, 3168
        • Monash Medical Centre
      • Epping, Victoria, Australien, 3076
        • The Cardiologists Proprietary Limited
      • Geelong, Victoria, Australien, 3220
        • Barwon Health Geelong Hospital
      • Ringwood, Victoria, Australien, 3134
        • GenesisCare Ringwood
    • Western Australia
      • Bentley, Western Australia, Australien, 6102
        • Curtin University Centre of Clinical Research and Education
      • Joondalup, Western Australia, Australien, 5068
        • HeartCare Western Australia - Joondalup
      • Murdoch, Western Australia, Australien, 6150
        • Fiona Stanley Hospital
  • Belgien
      • Aalst, Belgien, 9300
        • Algemeen Stedelijk Ziekenhuis Aalst
      • Aalst, Belgien, 9300
        • Onze Lieve Vrouw Ziekenhuis - campus Aalst
      • Antwerp, Belgien, 2020
        • Ziekenhuis Netwerk Antwerpen Middelheim
      • Antwerp, Belgien, 2060
        • Ziekenhuis Netwerk Antwerpen Stuivenberg
      • Brussels, Belgien, 1200
        • Universite Catholique de Louvain Cliniques Universitaires Saint Luc
      • Dendermonde, Belgien, 9200
        • AZ Sint Blasius
      • Ghent, Belgien, 9000
        • Algemeen Ziekenhuis Sint Lucas
      • Gozée, Belgien, 6534
        • Medif sprl
      • Ham, Belgien, 3945
        • Dokter Mortelmans bvba
      • Hasselt, Belgien, 3500
        • Jessa Ziekenhuis - Campus Virga Jesse
      • Leuven, Belgien, 3000
        • Universitair Ziekenhuis Leuven - Campus Gasthuisberg
      • Linkebeek, Belgien, 1630
        • Medilink sprl
      • Mons, Belgien, 7000
        • Centre Hospitalier Universitair Ambroise Pare
      • Overpelt, Belgien, 3900
        • Maria Ziekenhuis Noord-Limburg
      • Tessenderlo, Belgien, 3980
        • Testumed vzw
  • Brasilien
      • Rio de Janeiro, Brasilien, 20241-180
        • IBPClin Instituto Brasil de Pesquisa Clinica
      • São Paulo, Brasilien, 05403-000
        • Instituto do Coracao do Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo
    • Ceará
      • Fortaleza, Ceará, Brasilien, 60430-350
        • Centro de Pesquisas em Diabetes e Doencas Endocrino Metabolicas
    • Federal District
      • Brasília, Federal District, Brasilien, 71625-175
        • Centro de Pesquisa Clinica do Brasil
    • Minas Gerais
      • Belo Horizonte, Minas Gerais, Brasilien, 30150-240
        • Cardresearch Cardiologia Assistencial de Pesquisa
      • Belo Horizonte, Minas Gerais, Brasilien, 31110-580
        • Fundação Hospitalar São Francisco de Assis
      • Uberlândia, Minas Gerais, Brasilien, 38411-186
        • Eurolatino Pesquisas Medicas
    • Paraná
      • Campina Grande do Sul, Paraná, Brasilien, 83430-000
        • Sociedade Hospitalar Angelina Caron
      • Curitiba, Paraná, Brasilien, 80045-170
        • Quanta Diagnosticos e Terapia
      • Curitiba, Paraná, Brasilien, 80230-130
        • Puc Trials - Núcleo de Pesquisa Clínica da Escola de Medicina da Pucpr/Epicenter
      • Curitiba, Paraná, Brasilien, 80730-150
        • Nucleo de Pesquisa Clinica
    • Rio Grande do Sul
      • Porto Alegre, Rio Grande do Sul, Brasilien, 90610-000
        • Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul
      • Porto Alegre, Rio Grande do Sul, Brasilien, 91350-200
        • Hospital Nossa Senhora da Conceicao
      • Porto Alegre, Rio Grande do Sul, Brasilien, 90035-903
        • Núcleo de Pesquisa em Cirurgia Vascular
    • Santa Catarina
      • Blumenau, Santa Catarina, Brasilien, 89020-430
        • AngioCor Blumenau
    • São Paulo
      • Campinas, São Paulo, Brasilien, 13060-080
        • Instituto de Pesquisa Clínica de Campinas
      • Campinas, São Paulo, Brasilien, 13010-001
        • Centro Especializado em Cardiologia
      • Marília, São Paulo, Brasilien, 17515-000
        • Instituto do Coracao de Marilia
      • São José do Rio Preto, São Paulo, Brasilien, 15090-000
        • Fundação Faculdade Regional de Medicina de São José do Rio Preto
      • São Paulo, São Paulo, Brasilien, 01228-200
        • Centro de Pesquisas Clinicas Cpclin
  • Bulgarien
      • Burgas, Bulgarien, 8000
        • Ambulatory for special outpatient medical aid in Cardiology-Private Practice Dr Elena Dotcheva EOOD
      • Haskovo, Bulgarien, 6300
        • Multiprofile Hospital for Active Treatment - Haskovo AD
      • Pernik, Bulgarien, 2300
        • Specialty Hospital for Active treatment in Cardiology Sveti Georgi - Pernik OOD
      • Pleven, Bulgarien, 5800
        • Medical Center Medconsult OOD
      • Pleven, Bulgarien, 5800
        • University Multiprofile Hospital for Active Treatment Dr Georgi Stranski EAD
      • Plovdiv, Bulgarien, 4001
        • University Multiprofile Hospital for Active Treatment Sveti Georgi EAD
      • Plovdiv, Bulgarien, 4003
        • Multiprofile Hospital for Active Treatment- Medical Complex- Sveti Ivan Rilski EOOD
      • Sofia, Bulgarien, 1527
        • University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna - ISUL EAD
      • Sofia, Bulgarien, 1233
        • National Multiprofile Transport Hospital Tzar Boris III
      • Sofia, Bulgarien, 1233
        • Fifth Multiprofile Hospital for Active Treatment - Sofia EAD
      • Sofia, Bulgarien, 1309
        • Medical Center for Specialized Medical Care of Cardiovascular Diseases OOD
      • Sofia, Bulgarien, 1407
        • Acibadem City Clinic Multiprofile Hospital for Active Treatment Tokuda EAD
      • Sofia, Bulgarien, 1407
        • Medical Center Excelsior OOD
      • Sofia, Bulgarien, 1606
        • University Multiprofile Hospital for Active Treatment and Emergency Medicine N I Pirogov EAD
      • Sofia, Bulgarien, 1680
        • Diagnostic-Consultative Center Convex EOOD
      • Sofia, Bulgarien, 1680
        • Medical center Kalimat EOOD
      • Sofia, Bulgarien, 1750
        • Multiprofile Hospital for Active Treatment Sveta Anna Sofia AD
      • Stara Zagora, Bulgarien, 6000
        • Medical Center Orpheus OOD
      • Veliko Tarnovo, Bulgarien, 5002
        • Multiprofile Regional Hospital for Active Treatment Dr Stefan Cherkezov AD
  • Canada
    • Alberta
      • Calgary, Alberta, Canada, T2H 2G4
        • LMC Clinical Research Incorporated
    • British Columbia
      • Surrey, British Columbia, Canada, V3V 0C6
        • SMH Cardiology Clinical Trials Incorporated
      • Vancouver, British Columbia, Canada, V5Y 3W2
        • Dr T G Elliott Incorporated - BC Diabetes
    • Manitoba
      • Winnipeg, Manitoba, Canada, R3C 0N2
        • Winnipeg Clinic
    • New Brunswick
      • Moncton, New Brunswick, Canada, E1G 1A7
        • G A Research Associates Limited
    • Newfoundland and Labrador
      • Mount Pearl, Newfoundland and Labrador, Canada, A1N 1W7
        • Commonwealth Medical Clinic
    • Nova Scotia
      • Halifax, Nova Scotia, Canada, B3H 3A7
        • Queen Elizabeth II Health Sciences Centre, Halifax Infirmary
    • Ontario
      • Ajax, Ontario, Canada, L1Z 0B1
        • Heart Health Institute
      • Barrie, Ontario, Canada, L4N 7L3
        • LMC Clinical Research Incorporated
      • Brampton, Ontario, Canada, L6S 0C6
        • LMC Clinical Research Incorporated
      • Brampton, Ontario, Canada, L6Z 4N5
        • Brampton Clinical Trials
      • Concord, Ontario, Canada, L4K 4M2
        • LMC Clinical Research Incorporated Thornhill
      • Etobicoke, Ontario, Canada, M9R 4E1
        • LMC Clinical Research Incorporated
      • Hamilton, Ontario, Canada, L8L 2X2
        • Hamilton Health Sciences Hamilton General Hospital
      • London, Ontario, Canada, N6G 2M1
        • Western Centre for Public Health and Family Medicine - Western University
      • Markham, Ontario, Canada, L3P 7P2
        • My Endo Diabetes and Endocrinology Center
      • Nepean, Ontario, Canada, K2J 0V2
        • LMC Clinical Research Incorporated
      • Newmarket, Ontario, Canada, L3Y 5G8
        • SKDS Research Incorporated
      • Newmarket, Ontario, Canada, L3Y 2P6
        • Partners in Advanced Cardiac Evaluation
      • Oakville, Ontario, Canada, L6K 3W7
        • Oakville Cardiovascular Research
      • Oshawa, Ontario, Canada, L1J 2K1
        • Dr James Cha
      • Peterborough, Ontario, Canada, K9J 0B2
        • Kawartha Cardiology Clinical Trials
      • Sarnia, Ontario, Canada, N7T 4X3
        • Bluewater Clinical Research Group Incorporated
      • Scarborough Village, Ontario, Canada, M1B 4Z8
        • Heart Health Institute Research Incorporated
      • Scarborough Village, Ontario, Canada, M1B 5N1
        • Corcare Cardiovascular Research
      • Toronto, Ontario, Canada, M5S 1B2
        • Womens College Hospital
      • Toronto, Ontario, Canada, M6B 3H7
        • North York Diagnostic and Cardiac Centre
      • Weston, Ontario, Canada, M9N 1W4
        • Office of Dr Louis Yao
    • Quebec
      • Chicoutimi, Quebec, Canada, G7H 7K9
        • Ecogene-21
      • Lévis, Quebec, Canada, G6W 0M5
        • Manna Research Incorporated
      • Montreal, Quebec, Canada, H2W 1R7
        • Institut de recherches cliniques de Montréal
      • Montreal, Quebec, Canada, H3G 1A4
        • McGill University Health Centre - Montreal General Hospital
      • Montreal, Quebec, Canada, H1T 3Y7
        • Clinique Sante Cardio MC
      • Montreal, Quebec, Canada, H4A 3T2
        • Applied Medical Informatics Research Incorporated
      • Québec, Quebec, Canada, G1V 4W2
        • Clinique des Maladies Lipidiques de Quebec Incorporated
      • Saint-Jérôme, Quebec, Canada, J7Z 5T3
        • Centre intégré de santé et de services sociaux (CISSS) des Laurentides - Unité de recherche clini
  • Danmark
      • Aalborg, Danmark, 9000
        • Aalborg Hospital
      • Aalborg, Danmark, 9000
        • Center for Clinical and Basic Research Aalborg
      • Aarhus N, Danmark, 8200
        • Aarhus Universitetshospital
      • Ballerup Municipality, Danmark, 2750
        • Centre for Clinical and Basic Research Ballerup
      • Esbjerg, Danmark, 6700
        • Sydvestjysk Sygehus
      • Herlev, Danmark, 2730
        • Sanos Clinic
      • Herlev, Danmark, 2730
        • Steno Diabetes Center
      • Herning, Danmark, 7400
        • Regionhospitalet Herning
      • Hillerød, Danmark, 3400
        • Hillerod Hospital
      • Kolding, Danmark, 6000
        • Kolding Sygehus
      • København S, Danmark, 2300
        • Amager Hospital
      • København Ø, Danmark, 2100
        • Rigshospitalet Kobenhavn
      • Silkeborg, Danmark, 8600
        • Regionshospitalet Silkeborg
      • Svendborg, Danmark, 5700
        • Svendborg Sygehus
      • Vejle, Danmark, 7100
        • Center for Clinical and Basic Research Vejle
      • Viborg, Danmark, 8800
        • Regionshospitalet Viborg
  • Det Forenede Kongerige
      • Aberdeen, Det Forenede Kongerige, AB25 2ZN
        • Aberdeen Royal Infirmary
      • Barnsley, Det Forenede Kongerige, S75 2EP
        • Barnsley Hospital
      • Bath, Det Forenede Kongerige, BA1 3NG
        • Royal United Hospital
      • Belfast, Det Forenede Kongerige, BT16 1RH
        • Ulster Hospital
      • Belfast, Det Forenede Kongerige, BT12 6BA
        • Royal Victoria Hospital
      • Belfast, Det Forenede Kongerige, BT7 2EB
        • Ormeau Health Centre
      • Bollington, Det Forenede Kongerige, SK10 5JH
        • Bollington Medical Centre
      • Bournemouth, Det Forenede Kongerige, BH7 7DW
        • Royal Bournemouth Hospital
      • Bristol, Det Forenede Kongerige, BS37 4AX
        • West Walk Surgery
      • Burton-on-Trent, Det Forenede Kongerige, DE13 0RB
        • University Hospitals of Derby and Burton NHS Foundation Trust
      • Chesterfield, Det Forenede Kongerige, S40 4AA
        • Ashgate Medical Practice
      • Cleveleys, Det Forenede Kongerige, FY5 3LF
        • Cleveleys Group Practice
      • Corby, Det Forenede Kongerige, NN17 2UR
        • Lakeside Healthcare
      • Corby, Det Forenede Kongerige, NN18 9EZ
        • Medinova Northamptonshire Dedicated Research Site
      • Coventry, Det Forenede Kongerige, CV3 4FJ
        • MeDiNova Warwickshire Quality Research Site
      • Crawley, Det Forenede Kongerige, RH10 7DX
        • Pound Hill Medical Group
      • Dundee, Det Forenede Kongerige, DD1 9SY
        • Ninewells Hospital
      • Glasgow, Det Forenede Kongerige, G31 2ER
        • Glasgow Royal Infirmary
      • Hull, Det Forenede Kongerige, HU3 2RW
        • Hull Royal Infirmary
      • Inverness, Det Forenede Kongerige, IV2 3JH
        • Highlands Clinical Research Facility, Raigmore Hospital
      • Liverpool, Det Forenede Kongerige, L7 8XP
        • Royal Liverpool University Hospital
      • London, Det Forenede Kongerige, NW3 2QG
        • Royal Free London NHS Foundation Trust
      • London, Det Forenede Kongerige, SE1 9RT
        • Guys Hospital
      • London, Det Forenede Kongerige, EC1M 6BQ
        • Barts Health NHS Trust
      • Manchester, Det Forenede Kongerige, M23 9LT
        • Wythenshawe Hospital
      • Northwood, Det Forenede Kongerige, HA6 2RN
        • Medinova North London Dedicated Research Centre
      • Nottingham, Det Forenede Kongerige, NG5 1PB
        • Nottingham City Hospital
      • Nuneaton, Det Forenede Kongerige, CV10 7DJ
        • George Eliot Hospital
      • Orpington, Det Forenede Kongerige, BR5 3QG
        • Medinova South London Dedicated Research Centre
      • Penzance, Det Forenede Kongerige, TR19 7HX
        • Mounts Bay Medical Hub
      • Peterborough, Det Forenede Kongerige, PE7 1AT
        • The Health Centre Yaxley
      • Poole, Det Forenede Kongerige, BH16 5PW
        • The Adam Practice
      • Romford, Det Forenede Kongerige, RM1 3PJ
        • Medinova East London Dedicated Research Centre
      • Royal Leamington Spa, Det Forenede Kongerige, CV32 4RA
        • Sherbourne Medical Centre
      • Saint Neots, Det Forenede Kongerige, PE19 8BB
        • Eaton Socon Health Centre
      • Sandbach, Det Forenede Kongerige, CW11 1EQ
        • Ashfield Primary Care Centre
      • Scunthorpe, Det Forenede Kongerige, DN15 7BH
        • Scunthorpe General Hospital
      • Shipley, Det Forenede Kongerige, BD18 3SA
        • Medinova Limited
      • Stamford, Det Forenede Kongerige, PE9 2DH
        • Lakeside Healthcare Stamford
      • Stevenage, Det Forenede Kongerige, SG1 4AB
        • Lister Hospital
      • Swansea, Det Forenede Kongerige, SA2 8PP
        • Singleton Hospital
      • Thetford, Det Forenede Kongerige, IP24 1JD
        • The Breckland Alliance
      • Torquay, Det Forenede Kongerige, TQ2 7AA
        • Torbay Hospital
      • Wakefield, Det Forenede Kongerige, WF1 4DG
        • Pinderfields Hospital
      • Watford, Det Forenede Kongerige, WD25 7NL
        • Sheepcot Medical Practice
      • West Bromwich, Det Forenede Kongerige, B71 4HJ
        • Sandwell General Hospital
      • Whitby, Det Forenede Kongerige, YO21 1SD
        • Whitby Group Practice
      • Wokingham, Det Forenede Kongerige, RG40 1XS
        • MeDiNova West London Quality Research Site
      • Worcester, Det Forenede Kongerige, WR5 1DD
        • Worcestershire Royal Hospital
      • Yeovil, Det Forenede Kongerige, BA21 4AT
        • Yeovil District Hospital
  • Estland
      • Pärnu, Estland, 80014
        • Liina Viitas OÜ
      • Tallinn, Estland, 13419
        • North Estonia Medical Centre Foundation
      • Tallinn, Estland, 13419
        • Dr Arvo Rosenthal LLC
      • Tallinn, Estland, 10128
        • Center for Clinical and Basic Research Tallinn
  • Finland
      • Helsinki, Finland, 00029
        • Helsinki University Central Hospital
      • Helsinki, Finland, 00100
        • GERI-MED Oy
      • Joensuu, Finland, 80210
        • Pohjois-Karjalan keskussairaala
      • Jyväskylä, Finland, 40620
        • StudyCor Oy
      • Jyväskylä, Finland, 40100
        • Terveystalo Jyvaskyla
      • Kuopio, Finland, 70210
        • University of Eastern Finland
      • Kuopio, Finland, 70100
        • Satucon Oy/Kuopion tyoterveys
      • Oulu, Finland, 90220
        • Oulu University Hospital
      • Oulu, Finland, 90029
        • Oulu University Hospital
      • Tampere, Finland, 33520
        • Tampere University Hospital
      • Turku, Finland, 20100
        • Terveystalo Pulssi
  • Forenede Stater
    • Alabama
      • Athens, Alabama, Forenede Stater, 35611
        • North Alabama Research Center LLC
      • Birmingham, Alabama, Forenede Stater, 35243
        • Cardiovascular Associates
      • Huntsville, Alabama, Forenede Stater, 35801
        • Heart Center Research LLC
      • Mobile, Alabama, Forenede Stater, 36608
        • Mobile Heart Specialists PC
    • Arkansas
      • Little Rock, Arkansas, Forenede Stater, 72205
        • Central Arkansas Veterans Healthcare System
      • Little Rock, Arkansas, Forenede Stater, 72205
        • Arkansas Cardiology
    • California
      • Beverly Hills, California, Forenede Stater, 90211
        • Westside Medical Associates of Los Angeles
      • Beverly Hills, California, Forenede Stater, 90210
        • Cardiovascular Research Foundation of Southern California
      • Dublin, California, Forenede Stater, 94568
        • West Coast Research LLC
      • Palm Springs, California, Forenede Stater, 92262
        • Desert Oasis Healthcare Medical Group
      • Riverside, California, Forenede Stater, 92506
        • Covigilant Research, LLC
      • Roseville, California, Forenede Stater, 95661
        • Sierra Clinical Research
      • Sacramento, California, Forenede Stater, 95823
        • Center for Clinical Trials of Sacramento Inc
      • Torrance, California, Forenede Stater, 90502
        • Harbor University of California Los Angeles Medical Center
    • Colorado
      • Colorado Springs, Colorado, Forenede Stater, 80906
        • Optumcare Colorado Springs LLC
      • Colorado Springs, Colorado, Forenede Stater, 80909
        • University of Colorado Memorial Health System
      • Golden, Colorado, Forenede Stater, 80401
        • New West Physicians
      • Littleton, Colorado, Forenede Stater, 80120
        • South Denver Cardiology Associates
    • Connecticut
      • Stamford, Connecticut, Forenede Stater, 06905
        • Cardiology Associates of Fairfield County, PC
    • Florida
      • Boca Raton, Florida, Forenede Stater, 33434
        • Excel Medical Clinical Trials
      • Brandon, Florida, Forenede Stater, 33511
        • Bay Area Cardiology
      • Crystal River, Florida, Forenede Stater, 34429
        • Nature Coast Clinical Research LLC
      • Daytona Beach, Florida, Forenede Stater, 32114
        • Daytona Heart Group
      • Daytona Beach, Florida, Forenede Stater, 32117
        • Cardiology Research Associates
      • DeLand, Florida, Forenede Stater, 32720
        • Complete Health Research
      • Delray Beach, Florida, Forenede Stater, 33446
        • Cohen Medical Associates PA
      • Fort Lauderdale, Florida, Forenede Stater, 33312
        • Jellinger and Lerman MD PA dba The Center for Diabetes and Endocrine Care
      • Green Cove Springs, Florida, Forenede Stater, 32043
        • George E Platt MD
      • Hollywood, Florida, Forenede Stater, 33021
        • Research Physicians Network Alliance
      • Jacksonville, Florida, Forenede Stater, 32216
        • Jacksonville Center for Clinical Research
      • Jacksonville, Florida, Forenede Stater, 32209
        • University of Florida and Shands Hospital
      • Jacksonville, Florida, Forenede Stater, 32256
        • First Coast Cardiovascular Institute PA
      • Jacksonville Beach, Florida, Forenede Stater, 32250
        • Baptist Health Research Institute
      • Miami, Florida, Forenede Stater, 33173
        • Cardiovascular Research Center of South Florida
      • Miami, Florida, Forenede Stater, 33155
        • Gad Research Center
      • Ocala, Florida, Forenede Stater, 34471
        • Ocala Research Institute, Inc
      • Pensacola, Florida, Forenede Stater, 32501
        • Cardiology Consultants
      • Port Charlotte, Florida, Forenede Stater, 33952
        • Charlotte Heart Group Research Center
      • Sarasota, Florida, Forenede Stater, 34239
        • Cardiovascular Center of Sarasota
      • Sarasota, Florida, Forenede Stater, 34232
        • Intercoastal Medical Group
      • Winter Park, Florida, Forenede Stater, 32792
        • Florida Cardiology Group
      • Winter Park, Florida, Forenede Stater, 32792
        • The Florida Lipid Institute
    • Georgia
      • Johns Creek, Georgia, Forenede Stater, 30024
        • NSC Research
    • Idaho
      • Coeur d'Alene, Idaho, Forenede Stater, 83814
        • Kootenai Heart Clinics, LLC
    • Illinois
      • Arlington Heights, Illinois, Forenede Stater, 60005
        • Northwest Heart Clinical Research LLC
    • Indiana
      • Evansville, Indiana, Forenede Stater, 47713
        • Deaconess Clinic
      • Michigan City, Indiana, Forenede Stater, 46360
        • LaPorte County Institute for Clinical Research
    • Iowa
      • Davenport, Iowa, Forenede Stater, 52801
        • Midwest Cardiovascular Research Foundation
      • Iowa City, Iowa, Forenede Stater, 52242
        • The University of Iowa College of Public Health
      • West Des Moines, Iowa, Forenede Stater, 50266
        • MercyOne Iowa Heart Center
    • Kansas
      • Kansas City, Kansas, Forenede Stater, 66160-7601
        • The University of Kansas Medical Center
    • Kentucky
      • Covington, Kentucky, Forenede Stater, 41011
        • Saint Elizabeth Covington
      • Lexington, Kentucky, Forenede Stater, 40503
        • The Research Group of Lexington LLC
    • Louisiana
      • Alexandria, Louisiana, Forenede Stater, 71301
        • Alexandria Cardiology Clinic
      • Bossier City, Louisiana, Forenede Stater, 71111
        • Grace Research Llc
      • Eunice, Louisiana, Forenede Stater, 70535
        • Horizon Research Group of Opelousas LLC
      • Hammond, Louisiana, Forenede Stater, 70403
        • Louisiana Heart Center
      • Natchitoches, Louisiana, Forenede Stater, 71457
        • Barnum Medical Research
      • Shreveport, Louisiana, Forenede Stater, 71105
        • Grace Research Llc
      • Slidell, Louisiana, Forenede Stater, 70458
        • Louisiana Heart Center
    • Maine
      • Bangor, Maine, Forenede Stater, 04401
        • Northern Light Eastern Maine Medical Center
      • Biddeford, Maine, Forenede Stater, 04005
        • Southern Maine Health Care
    • Maryland
      • Baltimore, Maryland, Forenede Stater, 21229
        • Maryland Cardiovascular Specialists
      • Beltsville, Maryland, Forenede Stater, 20705
        • Metropolitan Cardiovascular Consultants LLC
      • Salisbury, Maryland, Forenede Stater, 21804
        • TidalHealth Peninsula Regional, Inc
    • Massachusetts
      • Boston, Massachusetts, Forenede Stater, 02215
        • Brigham and Womens Hospital
      • Framingham, Massachusetts, Forenede Stater, 01701
        • Charles River Medical Associates
      • Great Barrington, Massachusetts, Forenede Stater, 01230
        • East Mountain Medical Associates, PC
      • Springfield, Massachusetts, Forenede Stater, 01199
        • Baystate Health Center
    • Michigan
      • Flint, Michigan, Forenede Stater, 48504
        • Ahmed Arif Medical Research Center LLC
      • Grand Rapids, Michigan, Forenede Stater, 49546
        • Healthy Heart Cardiology
      • Jackson, Michigan, Forenede Stater, 49201
        • Rajendra H Mehta, MD, PC
      • Traverse City, Michigan, Forenede Stater, 49684
        • Munson Medical Center
    • Minnesota
      • Duluth, Minnesota, Forenede Stater, 55805
        • Saint Marys Medical Center
      • Minneapolis, Minnesota, Forenede Stater, 55407
        • Minneapolis Heart Institute Foundation
      • Saint Cloud, Minnesota, Forenede Stater, 56303
        • Saint Cloud Hospital
      • Saint Paul, Minnesota, Forenede Stater, 55102
        • HealthEast Medical Research Institute
    • Missouri
      • Kansas City, Missouri, Forenede Stater, 64128
        • Kansas City Veterans Affairs Medical Center
      • St Louis, Missouri, Forenede Stater, 63141
        • Mercy Research
    • Montana
      • Great Falls, Montana, Forenede Stater, 59405
        • Great Falls Clinic LLP
    • Nebraska
      • Lincoln, Nebraska, Forenede Stater, 68506
        • Bryan Heart
      • Omaha, Nebraska, Forenede Stater, 68105
        • Nebraska Western Iowa Health Care System
    • Nevada
      • Las Vegas, Nevada, Forenede Stater, 89128
        • Palm Research Center Inc
    • New Jersey
      • Voorhees Township, New Jersey, Forenede Stater, 08043
        • Virtua Health, Inc.
    • New York
      • Brooklyn, New York, Forenede Stater, 11206
        • Healthwise Medical Associates
      • Cheektowaga, New York, Forenede Stater, 14227
        • Trinity Medical Western New York, PC
      • Kingston, New York, Forenede Stater, 12401
        • WMCHealth Heart and Vascular Institute Kingston Division of Cardiology
      • Manhasset, New York, Forenede Stater, 11030
        • Northwell Health Physician Partners Cardiology
      • New Hyde Park, New York, Forenede Stater, 11042
        • North Shore Diabetes and Endocrine Associates
      • New York, New York, Forenede Stater, 10022
        • Northwell Health Lenox Hill Heart and Vascular
      • Poughkeepsie, New York, Forenede Stater, 12601
        • Hudson Valley Cardiovascular Physicians PC
      • Saratoga Springs, New York, Forenede Stater, 12866
        • Saratoga Clinical Research, LLC
      • Southampton, New York, Forenede Stater, 11968
        • Division of Cardiovascular Research at Peconic Bay Medical Center
    • North Carolina
      • Asheville, North Carolina, Forenede Stater, 28803
        • Asheville Cardiology Associates
      • Chapel Hill, North Carolina, Forenede Stater, 27599
        • University of North Carolina at Chapel Hill
      • Charlotte, North Carolina, Forenede Stater, 28204
        • Novant Health Heart and Vascular Institute
      • Greensboro, North Carolina, Forenede Stater, 27401
        • Moses H Cone Memorial Hospital
      • Mooresville, North Carolina, Forenede Stater, 28117
        • Crossroads Clinical Research Inc
      • Rocky Mount, North Carolina, Forenede Stater, 27804
        • Piedmont Medical Group Research of Rocky Mount
      • Salisbury, North Carolina, Forenede Stater, 28144
        • PMG Research of Salisbury
      • Winston-Salem, North Carolina, Forenede Stater, 27157
        • Wake Forest University Health Sciences
      • Winston-Salem, North Carolina, Forenede Stater, 27103
        • Novant Health Forsyth Medical Center
    • North Dakota
      • Fargo, North Dakota, Forenede Stater, 58104
        • Lillestol Research LLC
    • Ohio
      • Cincinnati, Ohio, Forenede Stater, 45219
        • The Christ Hospital
      • Cleveland, Ohio, Forenede Stater, 44106
        • University Hospitals Cleveland Medical Center
      • Elyria, Ohio, Forenede Stater, 44035
        • North Ohio Heart Center
      • Marion, Ohio, Forenede Stater, 43302
        • Sanjay Vora Research LLC
      • Sandusky, Ohio, Forenede Stater, 44870
        • North Ohio Heart Center-Sandusky
      • Springfield, Ohio, Forenede Stater, 45504
        • Heart House Research Foundation
    • Oklahoma
      • Norman, Oklahoma, Forenede Stater, 73069
        • Intend Research
      • Tulsa, Oklahoma, Forenede Stater, 74133
        • Oklahoma Heart Institute
    • Oregon
      • Portland, Oregon, Forenede Stater, 97239
        • Oregon Health and Science University
    • Pennsylvania
      • Camp Hill, Pennsylvania, Forenede Stater, 17011
        • Capital Area Research LLC
      • Camp Hill, Pennsylvania, Forenede Stater, 17011
        • Geisinger Holy Spirit
      • Doylestown, Pennsylvania, Forenede Stater, 18901
        • Doylestown Health Cardiology
      • Jersey Shore, Pennsylvania, Forenede Stater, 17740
        • Lycoming Internal Medicine Inc
      • Philadelphia, Pennsylvania, Forenede Stater, 19104
        • Perelman Center for Advanced Medicine
      • Philadelphia, Pennsylvania, Forenede Stater, 19107
        • Cardiology Consultants of Philadelphia CCP
      • Pittsburgh, Pennsylvania, Forenede Stater, 15213
        • University of Pittsburgh Medical Center
    • Rhode Island
      • Providence, Rhode Island, Forenede Stater, 02906
        • Miriam Hospital
    • South Carolina
      • Charleston, South Carolina, Forenede Stater, 29412
        • Pharmacorp Clinical Trials Inc
      • Fort Mill, South Carolina, Forenede Stater, 29707
        • Piedmont Research Partners
      • Greenville, South Carolina, Forenede Stater, 29607
        • Tribe Clinical Research LLC Dba Mountain View Clinical Research
      • Little River, South Carolina, Forenede Stater, 29566
        • Main Street Physicians Care Waterway
      • Murrells Inlet, South Carolina, Forenede Stater, 29576
        • The Diabetes Center
      • Summerville, South Carolina, Forenede Stater, 29485
        • Palmetto Clinical Research
    • South Dakota
      • Rapid City, South Dakota, Forenede Stater, 57701
        • Monument Health Clinical Research
    • Tennessee
      • Oak Ridge, Tennessee, Forenede Stater, 37830
        • Parkway Cardiology Associates
    • Texas
      • Dallas, Texas, Forenede Stater, 75235
        • Southwest Family Medicine Associates
      • Dallas, Texas, Forenede Stater, 75226
        • Soltero Cardiovascular Research Center
      • Kingwood, Texas, Forenede Stater, 77339
        • Texas Cardiology Associates of Houston
      • Kingwood, Texas, Forenede Stater, 77339
        • Humble Cardiology Associates
      • Lufkin, Texas, Forenede Stater, 75904
        • Texas Institute for Kidney and Endocrine Disorders
      • McKinney, Texas, Forenede Stater, 75071
        • Texas Institute of Cardiology
      • Mesquite, Texas, Forenede Stater, 75149
        • Southern Endocrinology Associates PA
      • Odessa, Texas, Forenede Stater, 79761
        • Permian Research Foundation
      • San Antonio, Texas, Forenede Stater, 78201
        • South Texas Cardiovascular Consultants PLLC
      • San Antonio, Texas, Forenede Stater, 78229
        • Mercury Medical Conversions LTD
      • Tomball, Texas, Forenede Stater, 77375
        • Northwest Houston Heart Center
    • Utah
      • Farmington, Utah, Forenede Stater, 84025
        • Alpine Research Organization
    • Virginia
      • Suffolk, Virginia, Forenede Stater, 23435
        • Suffolk Multispecialty Research LLC
      • Winchester, Virginia, Forenede Stater, 22601
        • Selma Medical Associates
    • Washington
      • Puyallup, Washington, Forenede Stater, 98372
        • MultiCare Institute for Research and Innovation
      • Tacoma, Washington, Forenede Stater, 98405
        • Universal Research Group LLC
    • Wisconsin
      • Wausau, Wisconsin, Forenede Stater, 54401
        • Aspirus Research Institute
  • Frankrig
      • Amiens, Frankrig, 80054
        • Centre Hospitalier Universitaire Amiens - Hopital Sud
      • Bron, Frankrig, 69677
        • Hospices Civils de Lyon Groupement Hospitalier Est, Hopital Louis Pradel
      • Caen, Frankrig, 14033
        • Centre Hospitalier Universitaire de Caen - Hopital Cote de Nacre
      • Corbeil-Essonnes, Frankrig, 91106
        • Centre Hospitalier Sud Francilien
      • Dijon, Frankrig, 21079
        • Centre Hospitalier Universitaire de Dijon - Hopital Francois Mitterrand
      • Grenoble, Frankrig, 38700
        • Centre Hospitalier Universitaire de Grenoble - Hopital Nord Michallon
      • Grenoble, Frankrig, 38000
        • Groupement Hospitalier Mutualiste
      • Le Chesnay, Frankrig, 78150
        • Centre Hospitalier de Versailles - Hopital Andre Mignot
      • Le Coudray, Frankrig, 28630
        • Hôpital Louis Pasteur
      • Lille, Frankrig, 59037
        • Centre Hospitalier Régional Universitaire de Lille - Institut Coeur Poumon
      • Lyon Cédex 3, Frankrig, 69437
        • Centre Hospitalier Universitaire de Lyon - Hopital Edouard Herriot
      • Marseille, Frankrig, 13285
        • Hôpital Saint-Joseph
      • Marseille, Frankrig, 13385
        • Centre Hospitalier Universitaire de Marseille - Hôpital de la Timone
      • Montpellier, Frankrig, 34295
        • Centre Hospitalier Régional Universitaire de Montpellier - Hôpital Arnaud de Villeneuve
      • Nantes, Frankrig, 44093
        • Centre Hospitalier Universitaire de Nantes - Hopital Guillaume et Rene Laennec
      • Nice, Frankrig, 06002
        • Centre Hospitalier Universitaire de Nice - Hopital Pasteur
      • Nîmes, Frankrig, 30029
        • Centre Hospitalier Universitaire de Nîmes
      • Paris, Frankrig, 75015
        • Hôpital Europeén Georges Pompidou
      • Paris, Frankrig, 75012
        • Hopital Saint Antoine
      • Paris, Frankrig, 75018
        • Hopital Bichat Claude Bernard
      • Paris, Frankrig, 75013
        • Hôpital Pitié-Salpêtrière
      • Pau, Frankrig, 64000
        • Centre Hospitalier de Pau - Hôpital François Mitterrand
      • Rennes, Frankrig, 35033
        • Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou
      • Rouen, Frankrig, 76000
        • Clinique Saint Hilaire
      • Toulouse, Frankrig, 31076
        • Clinique Pasteur
      • Toulouse, Frankrig, 31059
        • Centre Hospitalier Universitaire de Toulouse - Hopital Rangueil
      • Valenciennes, Frankrig, 59300
        • Polyclinique Vauban
  • Grækenland
      • Athens, Grækenland, 11527
        • General Hospital of Athens Laiko
      • Athens, Grækenland, 15123
        • Hygeia Hospital
      • Athens, Grækenland, 11528
        • Alexandra Hospital
      • Athens, Grækenland, 11527
        • General Hospital of Athens Georgios Gennimatas
      • Athens, Grækenland, 10676
        • General Hospital of Athens Evaggelismos
      • Athens, Grækenland, 11521
        • Athens Naval Hospital
      • Athens, Grækenland, 11527
        • General Hospital of Athens Ippokrateio
      • Athens, Grækenland, 14233
        • Konstantopoulio - Agia Olga Hospital of Nea Ionia
      • Heraklion, Grækenland, 71110
        • University Hospital of Heraklion
      • Ioannina, Grækenland, 45500
        • University Hospital of Ioannina
      • Larissa, Grækenland, 41110
        • University Hospital of Larissa
      • Thessaloniki, Grækenland, 56403
        • Papageorgiou General Hospital of Thessaloniki
      • Thessaloniki, Grækenland, 54636
        • Ahepa University Hospital
      • Thessaloniki, Grækenland, 54636
        • General Hospital of Thessaloniki Ahepa
      • Thessaloniki, Grækenland, 57001
        • Interbalkan Medical Center
  • Holland
      • Alkmaar, Holland, 1815 JD
        • Noordwest Ziekenhuisgroep
      • Almelo, Holland, 7609 PP
        • Ziekenhuisgroep Twente
      • Almere Stad, Holland, 1311 RL
        • Emotional Brain
      • Amersfoort, Holland, 3813 TZ
        • Meander Medisch Centrum
      • Amsterdam, Holland, 1105 AZ
        • Academisch Medisch Centrum
      • Amsterdam, Holland, 1091 AC
        • Onze Lieve Vrouwe Gasthuis
      • Amsterdam, Holland, 1061 AE
        • Onze Lieve Vrouwe Gasthuis
      • Apeldoorn, Holland, 7334 DZ
        • Gelre Ziekenhuis
      • Arnhem, Holland, 6815 AD
        • Rijnstate Ziekenhuis
      • Beverwijk, Holland, 1942 LE
        • Rode Kruis Ziekenhuis
      • Breda, Holland, 4818 CK
        • Amphia Ziekenhuis
      • Delft, Holland, 2625 AD
        • Reinier de Graaf Gasthuis
      • Deventer, Holland, 7416 SE
        • Deventer Ziekenhuis
      • Dirksland, Holland, 3247 BW
        • Van Weel Bethesda Ziekenhuis
      • Dordrecht, Holland, 3318 AT
        • Albert Schweitzer Ziekenhuis, Locatie Dordwijk
      • Dordrecht, Holland, 3318 AT
        • Albert Schweitzer Ziekenhuis location Dordwijk
      • Ede, Holland, 6716 RP
        • Ziekenhuis Gelderse Vallei
      • Eindhoven, Holland, 5623 EJ
        • Catharina Ziekenhuis
      • Emmen, Holland, 7824 AA
        • Treant Zorggroep, locatie Scheper ziekenhuis Emmen
      • Enschede, Holland, 7512 KZ
        • Medisch Spectrum Twente
      • Goes, Holland, 4462 RA
        • Admiraal de Ruyter Ziekenhuis
      • Gouda, Holland, 2803 HH
        • Groene Hart Ziekenhuis
      • Groningen, Holland, 9728 NT
        • Martini Ziekenhuis
      • Harderwijk, Holland, 3844 DG
        • Sint Jansdal Ziekenhuis
      • Heerlen, Holland, 6419 PC
        • Zuyderland Medisch Centrum
      • Helmond, Holland, 5707 HA
        • Elkerliek Ziekenhuis
      • Hilversum, Holland, 1213 XZ
        • Tergooi
      • Hoogeveen, Holland, 7909 AA
        • Bethesda Diabetes Research Center
      • Hoorn, Holland, 1624 NP
        • Dijklander Ziekenhuis Hoorn
      • Leeuwarden, Holland, 8934 AD
        • Medisch Centrum Leeuwarden
      • Leiden, Holland, 2333 ZA
        • Leids Universitair Medisch Centrum
      • Meppel, Holland, 7943 KA
        • Isala Diaconessenhuis
      • Nieuwegein, Holland, 3435 CM
        • Sint Antonius Ziekenhuis, locatie Nieuwegein
      • Nijmegen, Holland, 6525 GA
        • Radboudumc
      • Nijmegen, Holland, 6532 SZ
        • Canisius-Wilhelmina Ziekenhuis
      • Rotterdam, Holland, 3083 AN
        • Ikazia Ziekenhuis
      • Rotterdam, Holland, 3079 DZ
        • Maasstad ziekenhuis
      • Rotterdam, Holland, 3045 PM
        • Franciscus Gasthuis
      • Rotterdam, Holland, 3067 GJ
        • Praktijk Soerland
      • Schiedam, Holland, 3118 JH
        • Franciscus Vlietland
      • Sneek, Holland, 8601 ZR
        • D&A Research and Genetics
      • The Hague, Holland, 2545 AA
        • Haga Ziekenhuis
      • The Hague, Holland, 2572 GM
        • Huisartsenpraktijk Rambharose
      • Tiel, Holland, 4002 WP
        • Ziekenhuis Rivierenland
      • Tilburg, Holland, 5042 AD
        • Elisabeth-TweeSteden Ziekenhuis
      • Uden, Holland, 5406 PT
        • Ziekenhuis Bernhoven
      • Utrecht, Holland, 3584 CX
        • Universitair Medisch Centrum Utrecht
      • Utrecht, Holland, 3582 KE
        • Diakonessenhuis
      • Venlo, Holland, 5912 BL
        • VieCuri Medisch Centrum
      • Zaandam, Holland, 1502 DV
        • Zaans Medisch Centrum
      • Zwijndrecht, Holland, 3331 LZ
        • Albert Schweitzer ziekenhuis
      • Zwijndrecht, Holland, 3334 SB
        • Dokters van Nederhoven
      • Zwolle, Holland, 8025 AB
        • Isala Klinieken
  • Island
      • Kopavogur, Island, 201
        • Hjartamidstodin
      • Reykjavik, Island, 101
        • Landspitali
  • Italien
      • Augusta, Italien, 96011
        • Ospedale Muscatello
      • Bergamo, Italien, 24127
        • Azienda Socio Sanitaria Territoriale Papa Giovanni xxiii
      • Bologna, Italien, 40138
        • Azienda Ospedaliero Universitaria di Bologna Policlinico S Orsola Malpighi
      • Catanzaro, Italien, 88100
        • Azienda Ospedaliero Universitaria Mater Domini
      • Chieti, Italien, 66100
        • Universita degli Studi Gabriele D Annunzio di Chieti e Pescara
      • Massa, Italien, 54100
        • Fondazione Toscana Gabriele Monasterio Ospedale del Cuore G Pasquinucci
      • Milan, Italien, 20138
        • Centro Cardiologico Monzino
      • Milan, Italien, 20132
        • IRCCS Ospedale San Raffaele
      • Milan, Italien, 20162
        • Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
      • Pisa, Italien, 56100
        • Azienda Ospedaliero Universitaria Pisana
      • Pozzuoli, Italien, 80078
        • Presidio Ospedaliero Santa Maria Delle Grazie
      • Roma, Italien, 00189
        • Azienda Ospedaliera Sant Andrea
      • Roma, Italien, 00128
        • Policlinico Universitario Campus Biomedico
      • San Donato Milanese, Italien, 20097
        • IRCCS Policlinico San Donato
      • Torino, Italien, 10126
        • Azienda Ospedaliera Citta Della Salute E Della Scienza Di Torino
      • Udine, Italien, 33100
        • Azienda Ospedaliero Universitaria Integrata di Udine
  • Letland
      • Daugavpils, Letland, 5417
        • Daugavpils Regional Hospital
      • Ogre, Letland, 5001
        • Dace Teterovska Doctor Practice in Endocrinology
      • Ogre, Letland, 5001
        • Inga Jasinkevica Cardiologist Practice
      • Riga, Letland, 1002
        • Pauls Stradins Clinical University Hospital
      • Riga, Letland, 1012
        • Outpatient clinic Veselibas Centrs 4
  • Litauen
      • Alytus, Litauen, 63200
        • Klinikiniai sprendimai, UAB
      • Kaunas, Litauen, 50009
        • Hospital of Lithuanian University of Health Sciences Kaunas Clinics Public Institution
      • Kaunas, Litauen, 49387
        • Klinikiniai sprendimai, UAB
      • Kaunas, Litauen, 49456
        • Saules Seimos Medicinos Centras
      • Klaipėda, Litauen, 91131
        • Kardiologijos ir reabilitacijos klinika, UAB
      • Vilnius, Litauen, 08661
        • Vilnius University Hospital Santaros Clinic Public Institution
      • Šiauliai, Litauen, 76231
        • Siauliai Republican Hospital, Public Institution
  • Mexico
      • Aguascalientes, Mexico, 20230
        • Centro de investigacion Cardiometabolica
      • Chihuahua City, Mexico, 31203
        • SCIENTIA Investigacion Clinica SC
    • Mexico City
      • Cd de Mexico, Mexico City, Mexico, 06700
        • Clinstile SA de CV
    • Nuevo León
      • Monterrey, Nuevo León, Mexico, 64460
        • Unidad Biomédica Avanzada Monterrey
    • Querétaro
      • Querétaro City, Querétaro, Mexico, 76000
        • Centro de Estudios Clinicos de Queretaro
    • Sinaloa
      • Culiacán, Sinaloa, Mexico, 80230
        • Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada SC
  • Polen
      • Bydgoszcz, Polen, 85-094
        • Szpital Uniwersytecki nr 1 im dr Antoniego Jurasza w Bydgoszczy
      • Chrzanów, Polen, 32-500
        • American Heart of Poland Sa Malopolskie Centrum Sercowo-Naczyniowe PAKS - Chrzanow
      • Gdansk, Polen, 80-219
        • Uniwersyteckie Centrum Kliniczne
      • Gdansk, Polen, 80-462
        • Copernicus Podmiot Leczniczy Sp zoo
      • Gdynia, Polen, 81-394
        • NZOZ Srodmiescie Spzoo
      • Gdynia, Polen, 81-472
        • Marek Piepiorka Gabinet Kardiologiczno-Internistyczny
      • Giżycko, Polen, 11-500
        • Spolka Cywilna Medicina
      • Grodzisk Mazowiecki, Polen, 05-825
        • Samodzielny Publiczny Specjalistyczny Szpital Zachodni im swietego Jana Pawla II
      • Józefów, Polen, 05-410
        • Biokinetica SA
      • Katowice, Polen, 40-081
        • Centrum Medyczne Pratia Katowice
      • Kielce, Polen, 25-525
        • Specjalistyczna Poradnia Kardiologiczna i Nadcisnienia Tetniczego Beata Wozakowska-Kaplon
      • Kielce, Polen, 25-736
        • Wojewodzki Szpital Zespolony w Kielcach
      • Krakow, Polen, 30-082
        • Ewa Mirek-Bryniarska Specjalistyczna Praktyka Lekarska
      • Krakow, Polen, 31-135
        • Zespol Przychodni Specjalistycznych Diab-End-Cor Sp z oo
      • Krakow, Polen, 31-501
        • Krakowskie Centrum Medyczne Spzoo
      • Krakow, Polen, 31-514
        • CARINTART Sp zoo Krakowskie Centrum Diagnostyczno-Kliniczne
      • Krosno, Polen, 38-400
        • Intercard Spzoo Centrum Kardiologii Inwazyjnej Elektroterapii i Angiologii w Krosnie
      • Lodz, Polen, 93-338
        • Instytut Centrum Zdrowia Matki Polki
      • Lodz, Polen, 91-347
        • Wojewodzki Specjalistyczny Szpital im dr Wladyslawa Bieganskiego w Lodzi
      • Lubin, Polen, 59-300
        • Miedziowe Centrum Zdrowia Spolka Akcyjna
      • Lublin, Polen, 20-362
        • KO-MED Centra Kliniczne Lublin II
      • Lublin, Polen, 20-044
        • CenterMed Lublin Spzoo
      • Lublin, Polen, 20-078
        • Clinical Best Solutions Sp zoo Spolka Komandytowa Gabinet Lekarski
      • Lublin, Polen, 20-857
        • NZOZ Twoja Przychodnia Spzoo
      • Miechów, Polen, 32-200
        • Szpital Swietej Anny w Miechowie
      • Nowy Targ, Polen, 34-400
        • Podhalanski Szpital Specjalistyczny im Jana Pawla II w Nowym Targu
      • Piaseczno, Polen, 05-500
        • Centrum Medyczne Pulawska spzoo Centrum Medyczne Pulawska NZOZ
      • Poznan, Polen, 60-848
        • Clinical Research Center Spzoo Medic-R Spolka Komandytowa
      • Puławy, Polen, 24-100
        • KO-MED Centra Kliniczne Spzoo KO-MED Centra Kliniczne Pulawy
      • Płock, Polen, 09-402
        • NZOZ Specjalistyczna Przychodnia Lekarska Medikard
      • Ruda Śląska, Polen, 41-709
        • NZOZ Przychodnia Specjalistyczna Andrzej Wittek Henryk Rudzki spolka jawna
      • Siedlce, Polen, 08-110
        • Clinical Best Solutions Spolka z ograniczona odpowiedzialnoscia Spolka komandytowa
      • Skierniewice, Polen, 96-100
        • ETG Network Spzoo
      • Staszów, Polen, 28-200
        • KO-MED Centra Kliniczne Spzoo KO-MED Centra Kliniczne Staszow
      • Szczecin, Polen, 70-506
        • Indywidualna Specjalistyczna Praktyka Lekarska
      • Tarnów, Polen, 33-100
        • Centrum Szybkiej Diagnostyki Kardiologicznej Kardiomed M Zabowka E Zabowka Spolka cywilna
      • Torun, Polen, 87-100
        • Medical Trials Institute Spzoo
      • Torun, Polen, 87-100
        • Prywatne Centrum Kardiologii
      • Torun, Polen, 87-100
        • Wojewodzki Szpital Zespolony im Ludwika Rydygiera w Toruniu
      • Warsaw, Polen, 02-957
        • Instytut Psychiatrii i Neurologii
      • Warsaw, Polen, 01-868
        • Centrum Medyczne Pratia Warszawa
      • Warsaw, Polen, 01-518
        • Centrum Medyczne Amed Warszawa Zoliborz
      • Warsaw, Polen, 02-793
        • Clinical Best Solutions Sp zoo Spolka komandytowa
      • Warsaw, Polen, 04-073
        • Szpital Grochowski imienia Doktora medycyny Rafala Masztaka Spzoo
      • Wroclaw, Polen, 51-162
        • Centrum Badan Klinicznych Piotr Napora lekarze spolka partnerska
      • Wroclaw, Polen, 50-088
        • Futuremeds Spolka z ograniczona odpowiedzialnoscia
      • Wroclaw, Polen, 50-315
        • Centrum Kardiologiczne Pro Corde Spzoo Centrum Kardiologicne Pro Corde Wroclaw
      • Węgrów, Polen, 07-100
        • Samodzielny Publiczny Zaklad Opieki Zdrowotnej w Wegrowie
      • Włocławek, Polen, 87-800
        • Medicor Plus Kardiolodzy Spzoo
      • Zamość, Polen, 22-400
        • KO-MED Centra Kliniczne Spzoo KO-MED Centra Kliniczne Zamosc
      • Łęczna, Polen, 21-010
        • Samodzielny Publiczny Zakład Opieki Zdrowotnej w Lecznej
      • Świdnik, Polen, 21-040
        • Tomasz Blicharski Lubelskie Centrum Diagnostyczne
  • Portugal
      • Almada, Portugal, 2801-951
        • Hospital Garcia de Orta, EPE
      • Aveiro, Portugal, 3814-501
        • Centro Hospitalar do Baixo Vouga, EPE - Hospital Infante Dom Pedro
      • Carnaxide, Portugal, 2790-134
        • Centro Hospitalar de Lisboa Ocidental, EPE - Hospital de Santa Cruz
      • Coimbra, Portugal, 3000-075
        • Centro Hospitalar E Universitário de Coimbra EPE
      • Faro, Portugal, 8000-386
        • Hospital de Faro, EPE
      • Guimarães, Portugal, 4835-044
        • Hospital da Senhora da Oliveira, Guimaraes, EPE
      • Lisbon, Portugal, 1250-189
        • Associação Protectora dos Diabéticos de Portugal
      • Matosinhos Municipality, Portugal, 4464-513
        • Unidade Local de Saude de Matosinhos - Hospital Pedro Hispano
      • Viseu, Portugal, 3500-093
        • Hospital Casa de Saude Sao Mateus
  • Rumænien
      • Brasov, Rumænien, 500283
        • SC Centrul Medical de Diagnostic si Tratament Ambulator Neomed S.R.L
      • Bucharest, Rumænien, 050098
        • Spitalul Universitar de Urgenta Bucuresti
      • Bucharest, Rumænien, 011461
        • Spitalul Clinic Universitar de Urgenta Elias
      • Bucharest, Rumænien, 022328
        • Institutul de Urgenţă pentru Boli Cardiovasculare "Prof. Dr. C. C. Iliescu",
      • Craiova, Rumænien, 200512
        • Cardiomed SRL
      • Iași, Rumænien, 700547
        • Consultmed SRL
      • Iași, Rumænien, 700732
        • SC Cardiomed SRL
      • Oradea, Rumænien, 410151
        • SC Endodigest SRL
      • Piteşti, Rumænien, 110438
        • Sc Sal Med Srl
      • Târgu Mureş, Rumænien, 540143
        • Cmi Dr Podoleanu Cristian
      • Târgu Mureş, Rumænien, 540142
        • Mediab SRL
  • Rusland
      • Arkhangelsk, Rusland, 163001
        • First City Clinical Hospital na E E Volosevich
      • Barnaul, Rusland, 656038
        • NSHI Departmental Hospital at the station Barnaul of OJSC Russian Railways
      • Barnaul, Rusland, 656055
        • Regional State Budget Health care Institution Altay Regional Cardiology Dispensary
      • Ivanovo, Rusland, 153012
        • Regional Budget Healthcare Institution Cardiology Dispensary
      • Izhevsk, Rusland, 426063
        • BHI of Republic Udmurtiya City clinical hospital 9 of Ministry of healthcare of Republic Udmurtiya
      • Kemerovo, Rusland, 650002
        • FSBI Heart and Vessels Diseases complex problems Scientific Research Institution
      • Kirov, Rusland, 610014
        • Kirov Regional State Budget Healthcare Institution Kirov City Clinical Hospital 1
      • Krasnodar, Rusland, 350012
        • Regional Clinical Hospital 2 of the Ministry of Health Krasnodar region
      • Krasnodar, Rusland, 350086
        • SBHI Scientific Research Institute Regional Clinical Hospital 1 named after S V Ochapovsky
      • Moscow, Rusland, 101990
        • National Medical Research Center for therapy and preventive medicine
      • Moscow, Rusland, 111539
        • Moscow SBHI City Clinical Hospital 15 n a O M Filatov of Moscow Healthcare Department
      • Moscow, Rusland, 117292
        • SBHI of Moscow City clinical hospital 64 of Moscow Healthcare department
      • Moscow, Rusland, 121374
        • City Clinical Hospital named after Zhadkevich
      • Moscow, Rusland, 121552
        • FSBI Russian Cardiology Research and Production Complex
      • Nizhny Novgorod, Rusland, 603126
        • SBHI of Nizhny Novgorod region Nizhny Novgorod regional clinical hospital na N A Semashko
      • Novosibirsk, Rusland, 630005
        • LLC RC Medical
      • Novosibirsk, Rusland, 630047
        • SBHI of Novosibirsk Region City clinical hospital 1
      • Novosibirsk, Rusland, 630089
        • FSBSI Scientific Research Institute of Therapy and preventive medicine
      • Omsk, Rusland, 644018
        • Budget Healthcare Institution of Omsk region Medical-sanitary unit 9
      • Perm, Rusland, 614097
        • Perm Regional Hospital for War Veterans
      • Ryazan, Rusland, 390039
        • State Budget Institution of Ryazan Region Regional Clinical Hospital
      • Saint Petersburg, Rusland, 190031
        • City Polyclinic 27
      • Saint Petersburg, Rusland, 192283
        • Saint Petersburg State Budget Healthcare Institution City Polyclinic 109
      • Saint Petersburg, Rusland, 192289
        • Saint Petersburg State Budget Healthcare Institution City Polyclinic 109
      • Saint Petersburg, Rusland, 193312
        • City polyclinic 25 Nevsky district
      • Saint Petersburg, Rusland, 195112
        • SBHI Medical and sports dispensary of Krasnogvardeisky district of Saint Petersburg
      • Saint Petersburg, Rusland, 196601
        • Saint Petersburg SBHI City Hospital 38 named after N A Semashko
      • Saint Petersburg, Rusland, 197341
        • Almazov National Medical Research Centre
      • Saint Petersburg, Rusland, 199106
        • Saint Petersburg State Budget Healthcare Institution Pokrovskaya City Hospital
      • Saint Petersburg, Rusland, 199178
        • LLC Mart
      • Sait-Petersburg, Rusland, 194044
        • LLC Medinef Clinic
      • Samara, Rusland, 443070
        • Samara Regional Clinical Cardiology Dispensary
      • Saratov, Rusland, 410054
        • Clinical Hospital named after S R Mirotvortsev
      • Smolensk, Rusland, 214018
        • Regional State Budget Helthcare Institution Smolensk Regional Clinical Hospital
      • Sochi, Rusland, 354057
        • State Budgetary Health Institution City Hospital 4 of the City of Sochi
      • Tomsk, Rusland, 634012
        • FSBSI Tomsk National Research Medical Center of the Russian Academy of Sciences
      • Tyumen, Rusland, 625023
        • Tyumen State Medical University
      • Tyumen, Rusland, 625032
        • State Autonomous Healthcare Institution of the Tyumen region Medical Scientific Practical Center
      • Vladimir, Rusland, 600020
        • SBHI of Vladimirskaya region City Hospital 4 of Vladimir
      • Volgograd, Rusland, 400001
        • Family Medicine Clinic
      • Yekaterinburg, Rusland, 620026
        • Central City Clinical Hospital 1 of the Oktyabrsky District
      • Yekaterinburg, Rusland, 620102
        • State Budget Medical Institution Sverdlovsk Regional Clinical Hospital N1
  • Slovakiet
      • Bardejov, Slovakiet, 085 01
        • Alian, sro
      • Bratislava, Slovakiet, 831 03
        • MediTask, sro
      • Bratislava, Slovakiet, 833 48
        • Narodny ustav srdcovych a cievnych chorob, as
      • Bratislava, Slovakiet, 851 01
        • Veria, sro
      • Brezno, Slovakiet, 977 01
        • Nemocnica s poliklinikou Brezno, no
      • Košice, Slovakiet, 040 01
        • Medical group Kosice sro
      • Košice, Slovakiet, 040 22
        • Cardio D and R, sro Kosice
      • Lučenec, Slovakiet, 984 01
        • Kardio 1 sro
      • Moldava nad Bodvou, Slovakiet, 045 01
        • Medi M and M sro
      • Nitra, Slovakiet, 949 01
        • Kardiocentrum Nitra sro
      • Nové Zámky, Slovakiet, 940 01
        • Kardiomed NZ, sro
      • Námestovo, Slovakiet, 029 01
        • Oralek, sro
      • Prešov, Slovakiet, 080 01
        • Medikard, sro
      • Prešov, Slovakiet, 080 01
        • Medispol, sro
      • Rožňava, Slovakiet, 048 01
        • DIAB sro
      • Snina, Slovakiet, 069 01
        • Mediluk sro
      • Svidník, Slovakiet, 089 01
        • Interna SK, sro
      • Trebišov, Slovakiet, 075 01
        • Areteus sro
      • Trenčín, Slovakiet, 911 01
        • CardiOr, sro
  • Spanien
      • Madrid, Spanien, 28040
        • Fundación Jiménez Díaz
      • Madrid, Spanien, 28040
        • Hospital Clinico San Carlos
      • Madrid, Spanien, 28041
        • Hospital Universitario 12 de Octubre
      • Madrid, Spanien, 28046
        • Hospital Universitario La Paz
      • Madrid, Spanien, 28006
        • Hospital Universitario de La Princesa
      • Madrid, Spanien, 28702
        • Hospital Universitario Infanta Sofía
    • Andalusia
      • Almería, Andalusia, Spanien, 04120
        • Hospital Virgen del Mar
      • Córdoba, Andalusia, Spanien, 14004
        • Hospital Universitario Reina Sofia
      • Granada, Andalusia, Spanien, 18012
        • Hospital Universitario Virgen de las Nieves
      • Málaga, Andalusia, Spanien, 29010
        • Hospital Clinico Universitario Virgen de La Victoria
      • Seville, Andalusia, Spanien, 41009
        • Hospital Universitario Virgen Macarena
    • Aragon
      • Zaragoza, Aragon, Spanien, 50009
        • Hospital Universitario Miguel Servet
    • Canary Islands
      • Las Palmas de Gran Canarias, Canary Islands, Spanien, 35010
        • Hospital Universitario de Gran Canaria Doctor Negrin
    • Castille and León
      • Valladolid, Castille and León, Spanien, 47005
        • Hospital Clínico Universitario de Valladolid
    • Catalonia
      • Badalona, Catalonia, Spanien, 08916
        • Hospital Universitari Germans Trias i Pujol
      • Barcelona, Catalonia, Spanien, 08036
        • Hospital Clinic i Provincial de Barcelona
      • Barcelona, Catalonia, Spanien, 08025
        • Equip Atencio Primaria Sardenya
      • Reus, Catalonia, Spanien, 43204
        • Hospital Universitari Sant Joan de Reus
    • Galicia
      • A Coruña, Galicia, Spanien, 15006
        • Complexo Hospitalario Universitario A Coruña
      • Santiago de Compostela, Galicia, Spanien, 15706
        • Hospital Clínico Universitario de Santiago
      • Vigo, Galicia, Spanien, 36312
        • Hospital Alvaro Cunqueiro
    • Murcia
      • El Palmar, Murcia, Spanien, 30120
        • Hospital Universitario Virgen de la Arrixaca
    • Navarre
      • Pamplona, Navarre, Spanien, 31008
        • Complejo Hospitalario de Navarra
    • Valencia
      • Valencia, Valencia, Spanien, 46010
        • Hospital Clínico Universitario de Valencia
      • Valencia, Valencia, Spanien, 26026
        • Hospital Universitari i Politecnic La Fe
  • Sverige
      • Borås, Sverige, 501 82
        • Södra Älvsborgs Sjukhus
      • Falun, Sverige, 791 82
        • Falu Lasarett
      • Gothenburg, Sverige, 405 45
        • Carlanderska
      • Gothenburg, Sverige, 413 45
        • Sahlgrenska Universitetssjukhus
      • Helsingborg, Sverige, 252 20
        • PharmaSite Helsingborg
      • Härnösand, Sverige, 871 31
        • Obackakliniken i Harnosand
      • Jönköping, Sverige, 551 85
        • Länssjukhuset Ryhov
      • Karlstad, Sverige, 651 85
        • Centralsjukhuset Karlstad
      • Lidköping, Sverige, 531 85
        • Skaraborgs sjukhus Lidkoping
      • Lund, Sverige, 222 21
        • Clemenstorgets Hjartmottagning
      • Malmö, Sverige, 211 52
        • Pharmasite Malmo
      • Stockholm, Sverige, 117 27
        • Akardo MedSite
      • Umeå, Sverige, 901 85
        • Norrlands universitetssjukhus
      • Varberg, Sverige, 432 81
        • Hallands sjukhus Varberg
      • Östersund, Sverige, 831 83
        • Östersunds Sjukhus
  • Sydkorea
      • Busan, Sydkorea, 49201
        • Dong-A University Hospital
      • Busan, Sydkorea, 47392
        • Inje University Busan Paik Hospital
      • Cheongju-si, Chungcheongbuk-do, Sydkorea, 28644
        • Chungbuk National University Hospital
      • Daegu, Sydkorea, 42415
        • Yeungnam University Medical Center
      • Daegu, Sydkorea, 42601
        • Keimyung University, Dongsan Hospital
      • Gwangju, Sydkorea, 501-757
        • Chonnam National University Hospital
      • Incheon, Sydkorea, 21565
        • Gachon University Gil Medical Center
      • Seongnam-si, Gyeonggi-do, Sydkorea, 13620
        • Seoul National University Bundang Hospital
      • Seoul, Sydkorea, 03080
        • Seoul National University Hospital
      • Seoul, Sydkorea, 05505
        • Asan Medical Center
      • Seoul, Sydkorea, 06351
        • Samsung Medical Center
      • Seoul, Sydkorea, 03181
        • Kangbuk Samsung Hospital
      • Seoul, Sydkorea, 03722
        • Severance Hospital, Yonsei University Health System
      • Seoul, Sydkorea, 06591
        • The Catholic University of Korea Seoul St Marys Hospital
      • Seoul, Sydkorea, 02841
        • Korea University Anam Hospital
      • Seoul, Sydkorea, 02447
        • Kyung Hee University Hospital
      • Seoul, Sydkorea, 135-700
        • Gangnam Severance Hospital
      • Suwon-si, Gyeonggi-do, Sydkorea, 16499
        • Ajou University Hospital
      • Wonju-si, Gangwon-do, Sydkorea, 26426
        • Yonsei University Wonju Severance Christian Hospital
  • Taiwan
      • Kaohsiung City, Taiwan, 83301
        • Kaohsiung Chang Gung Memorial Hospital
      • Kaohsiung City, Taiwan, 80756
        • Kaohsiung Medical University Chung-Ho Memorial Hospital
      • New Taipei City, Taiwan, 25160
        • MacKay Memorial Hospital Tamsui Branch
      • Taichung, Taiwan, 40705
        • Taichung Veterans General Hospital
      • Taichung, Taiwan, 40201
        • Chung Shan Medical University Hospital
      • Tainan, Taiwan, 70403
        • National Cheng Kung University Hospital
      • Taipei, Taiwan, 10002
        • National Taiwan University Hospital
      • Taipei, Taiwan, 11217
        • Taipei Veterans General Hospital
      • Taoyuan, Taiwan, 33305
        • Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation
    • Hualien
      • Hualien City, Hualien, Taiwan, 97002
        • Hualien Tzu Chi Hospital
  • Tjekkiet
      • Benátky nad Jizerou, Tjekkiet, 294 71
        • MUDr Igor Karen
      • Beroun, Tjekkiet, 266 01
        • Jessenia as, Nemocnice Beroun
      • Beroun, Tjekkiet, 266 01
        • Medicentrum Beroun sro
      • Brandýs nad Labem, Tjekkiet, 250 01
        • Medicus Services sro
      • Brno, Tjekkiet, 625 00
        • Fakultni nemocnice Brno
      • Brno, Tjekkiet, 636 00
        • Vojenska nemocnice Brno
      • Brno, Tjekkiet, 602 00
        • Amkardia sro
      • Brno, Tjekkiet, 602 00
        • CCR Brno sro
      • Brno, Tjekkiet, 603 00
        • Centrum pro zdravi sro
      • Brno, Tjekkiet, 612 00
        • Kardiologicka ambulance Brno sro
      • Brno, Tjekkiet, 638 00
        • prof MUDr Lubomir Elbl, CSc, Kardiologicka ambulance
      • Broumov, Tjekkiet, 550 01
        • Edumed sro, Kardiologicka ambulance
      • Havirov - Mesto, Tjekkiet, 736 01
        • Dika centrum sro
      • Hodonín, Tjekkiet, 695 01
        • Clinical Trial Center Hodonin sro
      • Holešov, Tjekkiet, 769 01
        • Kardio Holesov sro
      • Hradec Králové, Tjekkiet, 500 02
        • MUDr Ladislava Harrerova, kardiologicka ordinace
      • Karlovy Vary, Tjekkiet, 360 01
        • Karlovarska krajska nemocnice
      • Kladno, Tjekkiet, 272 59
        • Oblastni nemocnice Kladno as
      • Klatovy IV, Tjekkiet, 339 01
        • Kardio Michal Cepelak sro
      • Kolin III, Tjekkiet, 280 02
        • Oblastni nemocnice Kolin as
      • Liberec, Tjekkiet, 460 63
        • Krajska nemocnice Liberec as
      • Louny, Tjekkiet, 440 01
        • KardioBusak sro
      • Ludgeřovice, Tjekkiet, 747 14
        • Kardio Pudich s.r.o.
      • Milevsko, Tjekkiet, 399 01
        • Vseobecna intermi ambulance sro
      • Mladá Boleslav, Tjekkiet, 293 01
        • MUDr Zbynek Kosek, kardiologicka ambulance sro
      • Mohelnice, Tjekkiet, 789 85
        • Pozdisek sro, Kardiologicka ambulance
      • Ostrava, Tjekkiet, 702 00
        • CCR Ostrava sro
      • Ostrava, Tjekkiet, 728 80
        • Mestska nemocnice Ostrava
      • Ostrava - Poruba, Tjekkiet, 708 00
        • Benedor sro - Kardiologicka, cevni a interni ambulance
      • Ostrava-Dubina, Tjekkiet, 700 30
        • Kardiologicka a Angiologicka Ambulance
      • Pardubice, Tjekkiet, 530 02
        • Center for Clinical Research Pardubice, sro
      • Pardubice, Tjekkiet, 532 03
        • Nemocnice Pardubickeho kraje as
      • Pilsen, Tjekkiet, 310 01
        • Kardiologie v sadech sro
      • Prague, Tjekkiet, 128 08
        • Vseobecna fakultni nemocnice v Praze
      • Prague, Tjekkiet, 140 59
        • Thomayerova nemocnice
      • Prague, Tjekkiet, 150 06
        • Fakultni nemocnice v Motole
      • Prague, Tjekkiet, 198 00
        • Endokrinologie Cerny Most sro
      • Prague, Tjekkiet, 149 00
        • Milan Kvapil sro
      • Prague, Tjekkiet, 101 00
        • Ordinace pro choroby srdce a cev
      • Prague, Tjekkiet, 110 00
        • Diabet2 sro
      • Prague, Tjekkiet, 130 00
        • CCR Prague sro
      • Prague, Tjekkiet, 158 00
        • Interni a kardiologicka ordinace
      • Praha 10 - Zabehlice, Tjekkiet, 106 00
        • Kardiologie Cor sro
      • Praha 5 - Smichov, Tjekkiet, 150 00
        • Kardiologicke centrum MUDr Janky Skrobakove sro
      • Přerov, Tjekkiet, 750 02
        • Kardio Vaclavik sro, Interni a kardiologicka ambulance
      • Rychnov nad Kněžnou, Tjekkiet, 516 01
        • Vestra Clinics sro
      • Svitavy, Tjekkiet, 568 25
        • Nemocnice Pardubickeho kraje as, Svitavska nemocnice
      • Teplice, Tjekkiet, 415 01
        • AeskuLab ks, Lipidova poradna
      • Třinec, Tjekkiet, 739 61
        • Nemocnice Podlesi as
      • Uherské Hradiště, Tjekkiet, 686 01
        • Interni ambulance
      • Uherské Hradiště, Tjekkiet, 686 01
        • Clinical Trials Service sro
      • Zlín, Tjekkiet, 760 01
        • Lekarsky dum Ormiga
      • Znojmo, Tjekkiet, 669 02
        • KIGE sro
      • České Budějovice, Tjekkiet, 370 11
        • Cevni centrum Ceske Budejovice sro
  • Tyskland
      • Bad Krozingen, Tyskland, 79189
        • Universitaets-Herzzentrum Freiburg - Bad Krozingen
      • Bad Neuheim, Tyskland, 61231
        • Kerckhoff-Klinik Forschungs GmbH
      • Berlin, Tyskland, 10787
        • Klinische Forschung Berlin GbR
      • Berlin, Tyskland, 13353
        • Charite Universitätsmedizin Berlin, Charité Campus Virchow-Klinikum
      • Bremen, Tyskland, 28277
        • Kardiologisch - Angiologische Praxis - Herzzentrum Bremen
      • Dortmund, Tyskland, 44137
        • Sankt-Johannes-Hospital
      • Dresden, Tyskland, 01277
        • Cardiologicum Dresden und Pirna
      • Dresden, Tyskland, 01279
        • Diabetologische Gemeinschaftspraxis Dr Schaper und Dr Faulmann
      • Dresden, Tyskland, 01307
        • Universitaetsklinikum Carl Gustav Carus, Medizinische Klinik und Poliklinik III
      • Frankfurt am Main, Tyskland, 60590
        • Klinikum und Fachbereich Medizin Johann Wolfgang Goethe-Universität Frankfurt am Main
      • Frankfurt am Main, Tyskland, 60596
        • Clin Phenomics GmbH Co KG
      • Fulda, Tyskland, 36037
        • Medizinisches Versorgungszentrum im Altstadt-Carree Fulda
      • Hamburg, Tyskland, 22041
        • Cardiologicum Hamburg
      • Heidelberg, Tyskland, 69120
        • Universitatsklinikum Heidelberg
      • Kassel, Tyskland, 34121
        • Ambulantes Herzzentrum Kassel
      • Leipzig, Tyskland, 4103
        • Universitatsklinikum Leipzig
      • Magdeburg, Tyskland, 39120
        • Otto von Guericke Universität Magdeburg
      • Mainz, Tyskland, 55131
        • Johannes Gutenberg Universitaet Mainz
      • Mannheim, Tyskland, 68167
        • Universitätsklinikum Mannheim
      • Markleeberg, Tyskland, 04416
        • Praxis Doktor Jens Taggeselle
      • München, Tyskland, 80636
        • Deutsches Herzzentrum München des Freistaates Bayern
      • München, Tyskland, 80638
        • Herz Gefaess Zentrum Nymphenburg
      • Münster, Tyskland, 48149
        • Universitaetsklinikum Muenster
      • Papenburg, Tyskland, 26871
        • Kardiologische Gemeinschaftspraxis Papenburg
      • Potsdam, Tyskland, 14467
        • Klinikum Ernst von Bergmann gGmbH
      • Regensburg, Tyskland, 93053
        • Universitätsklinikum Regensburg
      • Rostock, Tyskland, 18059
        • CardioConsil GmbH
      • Singen, Tyskland, 78224
        • I Medizinische Klinik Gesundheitsverbund Landkreis Konstanz
      • Ulm, Tyskland, 89081
        • Universitätsklinikum Ulm
      • Villingen-Schwenningen, Tyskland, 78052
        • Nephrologisches Zentrum Villingen-Schwenningen
      • Witten, Tyskland, 58455
        • Forschungszentrum Ruhr
  • Ukraine
      • Ivano-Frankivsk, Ukraine, 76018
        • Ivano-Frankivsk Regional Clinical Cardiology Center of Ivano-Frankivsk Regional Council
      • Kharkiv, Ukraine, 61002
        • Communal Healthcare Institution Kharkiv City Clinical Hospital No27
      • Kharkiv, Ukraine, 61106
        • Medical and Sanitary Unit of Open Joint Stock Company Kharkiv Tractor Plant
      • Kharkiv, Ukraine, 61176
        • Communal Noncommercial enterprise "City Hospital #8" of Kharkiv City Council
      • Kyiv, Ukraine, 01023
        • Oleksandrivska Clinical Hospital of Kyiv
      • Kyiv, Ukraine, 02091
        • Kyiv City Clinical Hospital 1
      • Kyiv, Ukraine, 02232
        • Communal Noncommercial Institution Consultative and Diagnostic Center of Desnianskyi District of Kyi
      • Kyiv, Ukraine, 02660
        • Kyiv City Clinical Emergency Medical Care Hospital
      • Kyiv, Ukraine, 03151
        • National Scientific Center "M.D. Strazhesko Institute of Cardiology"
      • Kyiv, Ukraine, 03680
        • State Institution National Scientific Center Acad MD Strazhesko Institute of cardiology of NAMS Ukr
      • Kyiv, Ukraine, 03680
        • State Institution National Scientific Center Acad Strazhesko Institute of Cardiology
      • Kyiv, Ukraine, 04050
        • Medical Centre CONSILIUM Medical
      • Uzhhorod, Ukraine, 88014
        • Zakarpattia Oblast Clinical Center of Cardiology and Cardio Surgery
      • Vinnytsia, Ukraine, 21018
        • Vinnytsia M I Pyrogov Regional Clinical Hospital Vinnytsia M I Pyrogov National Medical University
      • Vinnytsia, Ukraine, 21001
        • Private Small Enterprise, Medical Center Pulse
      • Zaporizhzhia, Ukraine, 69035
        • Communal Non-commercial enterprise "City Hospital #6 "of Zaporizhzhia City Council
  • Ungarn
      • Baja, Ungarn, 6500
        • Lausmed Kft
      • Balatonfüred, Ungarn, 8230
        • Allami Szivkorhaz Balatonfured
      • Balatonkeresztúr, Ungarn, 8647
        • Balatonmariafurdo Kozseg Onkormanyzatanak Haziorvosi Rendeloje
      • Ballószög, Ungarn, 6035
        • Med-Edu Bt
      • Berettyóújfalu, Ungarn, 4100
        • Grof Tisza Istvan Korhaz
      • Budapest, Ungarn, 1036
        • Obudai Egeszsegugyi Centrum Kft
      • Budapest, Ungarn, 1204
        • Jahn Ferenc Del-pesti Korhaz es Rendelointezet
      • Budapest, Ungarn, 1145
        • Uzsoki Utcai Korhaz
      • Budapest, Ungarn, 1096
        • Gottsegen György Országos Kardiológiai Intézet
      • Budapest, Ungarn, 1106
        • Bajcsy-Zsilinszky Korhaz es Rendelointezet
      • Budapest, Ungarn, 1122
        • Semmelweis Egyetem
      • Budapest, Ungarn, 1134
        • Magyar Honvedseg Egeszsegugyi Kozpont
      • Budapest, Ungarn, 1023
        • Betegapolo Irgalmas Rend - Budai Irgalmasrendi Korhaz
      • Budapest, Ungarn, 1033
        • Clinexpert Kft
      • Budapest, Ungarn, 1085
        • Semmelweis Egyetem Varosmajori Sziv- es Ergyogyaszati Klinika
      • Budapest, Ungarn, 1148
        • Zugloi Egeszsegugyi Szolgalat
      • Békéscsaba, Ungarn, 5600
        • Dr Lakatos Ferenc Private Cardiology Practice
      • Debrecen, Ungarn, 4032
        • Debreceni Egyetem Klinikai Kozpont
      • Eger, Ungarn, 3300
        • Markhot Ferenc Oktatokorhaz és Rendelointezet
      • Gyula, Ungarn, 5700
        • Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaz
      • Gyöngyös, Ungarn, 3200
        • Bugat Pal Korhaz
      • Gyöngyös, Ungarn, 3200
        • Pharma4 Trial Kft
      • Gödöllő, Ungarn, 2100
        • Erzsebet Gondozohaz
      • Hatvan, Ungarn, 3000
        • BKS Research Kft
      • Kalocsa, Ungarn, 6300
        • Bacs-Kiskun Megyei Korhaz Szegedi Tudomanyegyetem Altalanos Orvostudomanyi Kar Oktato Korhaza
      • Komárom, Ungarn, 2921
        • Selye János Kórház
      • Miskolc, Ungarn, 3526
        • Borsod-Abauj-Zemplen Megyei Kozponti Korhaz es Egyetemi Oktatokorhaz
      • Miskolc, Ungarn, 3529
        • CRU Hungary Kft
      • Pécs, Ungarn, 7624
        • Pécsi Tudományegyetem Klinikai Központ
      • Sopron, Ungarn, 9400
        • Soproni Erzsebet Oktato Korhaz es Rehabilitacios Intezet
      • Szeged, Ungarn, 6725
        • Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont Altalanos Orvostudomanyi Kar
      • Szeged, Ungarn, 6725
        • Szegedi Tudomanyegyetem Szent Gyorgyi Albert Klinikai Kozpont Altalanos Orvostudomanyi Kar
      • Szekszárd, Ungarn, 7100
        • Tolna Megyei Balassa Janos Korhaz
      • Szentes, Ungarn, 6600
        • Csongrad Megyei Dr Bugyi Istvan Korhaz
      • Szolnok, Ungarn, 5004
        • Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rendelointezet
      • Székesfehérvár, Ungarn, 8000
        • Praxispont Belvarosi Maganegeszsegugyi Kozpont
      • Zalaegerszeg, Ungarn, 8900
        • Belvarosi Egeszseghaz Kft
  • Østrig
      • Feldkirch, Østrig, 6800
        • Landeskrankenhaus Feldkirch
      • Graz, Østrig, 8036
        • Medizinische Universitaet Graz
      • Innsbruck, Østrig, 6020
        • Medizinische Universitaet Innsbruck
      • Klagenfurt, Østrig, 9020
        • Klinikum Klagenfurt am Woerthersee
      • Linz, Østrig, 4010
        • Ordensklinikum Linz Barmherzige Schwestern
      • Vienna, Østrig, 1160
        • Klinik Ottakring
      • Vienna, Østrig, 1030
        • Klinik Landstrasse
      • Vienna, Østrig, 1090
        • Universitaetsklinikum Allgemeines Krankenhaus Wien
      • Vienna, Østrig, 1130
        • Klinik Hietzing
      • Vienna, Østrig, 1060
        • Zentrum fuer klinische Studien - Dr Hanusch GmbH

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

46 år til 75 år (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Beskrivelse

Inklusionskriterier:

  1. Alder: Voksne forsøgspersoner ≥ 50 (mænd) eller ≥ 55 (kvinder) til ˂ 80 år (begge køn) og opfylder lipidkriterier
  2. Low-density lipoprotein kolesterol (LDL-C) ≥ 90 mg/dL (≥ 2,3 mmol/L) eller non-high-density lipoprotein kolesterol (non-HDL) ≥ 120 mg/dL (≥ 3,1 mmol/L), eller apolipoprotein B ≥ 80 mg/dL (≥ 1,56 µmol/L)

  3. Bevis for mindst én af følgende ved screening (uden forudgående myokardieinfarkt eller slagtilfælde):

    A. Signifikant koronararteriesygdom (CAD) B. Signifikant aterosklerotisk cerebrovaskulær sygdom C. Signifikant perifer arteriel sygdom D. Diabetes mellitus

  4. Mindst 1 højrisikofunktion

Eksklusionskriterier

  • MI eller slagtilfælde før randomisering
  • Koronararterie bypass grafting (CABG) ˂ 3 måneder før screening
  • Estimeret glomerulær filtrationshastighed (eGFR) ˂ 15 mL/min/1,73 m²
  • Ukontrolleret eller tilbagevendende ventrikulær takykardi i fravær af en implanterbar cardioverter-defibrillator.
  • Atrieflimren eller atrieflimren er ikke under antikoaguleringsbehandling (K-vitaminantagonist, heparin, lavmolekylær heparin, fondaparinux eller ikke-vitamin K-antagonist oralt antikoagulant)
  • Triglycerider ≥ 500 mg/dL (5,7 mmol/L) målt op til 3 måneder før screening. De seneste resultater skal bruges.
  • Sidst målte venstre ventrikulære ejektionsfraktion ˂ 30 % eller New York Heart Association (NYHA) Funktionsklasse III/IV
  • Planlagt arteriel revaskularisering

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Behandling
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Firedobbelt

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Placebo komparator: Placebo
Deltagerne vil modtage placebo subkutan injektion én gang hver anden uge (Q2W).
Medicin: Placebo
Indgivet subkutant med en autoinjektorpen.
Eksperimentel: Evolocumab 140 mg Q2W
Deltagerne vil modtage 140 mg evolocumab ved subkutan injektion Q2W.
Medicin: Evolocumab
Indgivet subkutant med en autoinjektorpen.
Andre navne:
  • Repatha
  • AMG 145

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Number of Participants Who Experienced Coronary Heart Disease (CHD) Death, Myocardial Infarction (MI), or Ischemic Stroke, Whichever Occurred First
Tidsramme: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
All deaths and individual components were adjudicated by an independent external clinical events committee (CEC), using standardized definitions. The number of participants who experienced CHD death, MI, or ischemic stroke, whichever occurred first, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.
From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
Number of Participants Who Experienced CHD Death, MI, Ischemic Stroke, or Any Ischemia-driven Arterial Revascularization, Whichever Occurred First
Tidsramme: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced CHD death, MI, ischemic stroke, or any ischemia-driven arterial revascularization, whichever occurred first, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.
From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Number of Participants Who Experienced MI, Ischemic Stroke, or Any Ischemia-driven Arterial Revascularization
Tidsramme: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced MI, ischemic stroke, or any ischemia-driven arterial revascularization, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.
From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
Number of Participants Who Experienced CHD Death, MI, or Any Ischemia-driven Arterial Revascularization
Tidsramme: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced CHD death, MI, or any ischemia-driven arterial revascularization, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.
From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
Number of Participants Who Experienced Cardiovascular Death, MI, or Ischemic Stroke
Tidsramme: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced cardiovascular death, MI, or ischemic stroke, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.
From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
Number of Participants Who Experienced CHD Death or MI
Tidsramme: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced CHD death or MI, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.
From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
Number of Participants Who Experienced MI
Tidsramme: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced MI, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.
From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
Number of Participants Who Experienced Any Ischemia-driven Arterial Revascularization
Tidsramme: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced ischemia-driven arterial revascularization, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.
From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
Number of Participants Who Experienced CHD Death
Tidsramme: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced CHD death, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.
From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
Number of Participants Who Experienced Cardiovascular Death
Tidsramme: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced cardiovascular death, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.
From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
Number of Participants Who Died Due to Any Cause
Tidsramme: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who died due to any cause, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.
From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
Number of Participants Who Experienced Ischemic Stroke
Tidsramme: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced ischemic stroke, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.
From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Amgen

Efterforskere

  • Studieleder: MD, Amgen

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Hjælpsomme links

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

11. juni 2019

Primær færdiggørelse (Faktiske)

25. juli 2025

Studieafslutning (Faktiske)

25. juli 2025

Datoer for studieregistrering

Først indsendt

11. marts 2019

Først indsendt, der opfyldte QC-kriterier

11. marts 2019

Først opslået (Faktiske)

13. marts 2019

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

25. juni 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

1. juni 2026

Sidst verificeret

1. juni 2026

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • 20170625
  • 2018-004565-14 (EudraCT nummer)
  • 2023-503673-38-00 (Ctis)

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

JA

IPD-planbeskrivelse

Afidentificerede individuelle patientdata for variabler, der er nødvendige for at løse det specifikke forskningsspørgsmål i en godkendt anmodning om datadeling.

IPD-delingstidsramme

Anmodninger om datadeling i forbindelse med denne undersøgelse vil blive overvejet begyndende 18 måneder efter undersøgelsens afslutning, og enten 1) Produktet og indikationen er blevet udstedt markedsføringstilladelse i både USA og Europa eller 2) klinisk udvikling af produktet og/eller indikationen ophører og dataene vil ikke blive indsendt til de regulerende myndigheder. Der er ingen slutdato for berettigelse til at indsende en anmodning om datadeling for denne undersøgelse.

IPD-delingsadgangskriterier

Kvalificerede forskere kan indsende en anmodning, der indeholder forskningsmålene, Amgen-produktet/-erne og Amgen-undersøgelsen/-undersøgelserne i omfang, endepunkter/resultater af interesse, statistisk analyseplan, datakrav, publikationsplan og forskerens/forskernes kvalifikationer. Generelt imødekommer Amgen ikke eksterne anmodninger om individuelle patientdata med det formål at revurdere sikkerheds- og effektivitetsspørgsmål, der allerede er behandlet i produktmærkningen. Anmodninger gennemgås af et udvalg af interne rådgivere. Hvis den ikke godkendes, vil et uafhængigt datadelingspanel mægle og træffe den endelige beslutning. Efter godkendelse vil oplysninger, der er nødvendige for at løse forskningsspørgsmålet, blive leveret i henhold til vilkårene i en datadelingsaftale. Dette kan omfatte anonymiserede individuelle patientdata og/eller tilgængelige understøttende dokumenter, der indeholder fragmenter af analysekode, hvor det er angivet i analysespecifikationerne. Yderligere detaljer er tilgængelige på linket nedenfor.

IPD-deling Understøttende informationstype

  • STUDY_PROTOCOL
  • SAP
  • ICF
  • CSR

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Ja

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Abonner