Effect of Evolocumab in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke (VESALIUS-CV)

November 7, 2025 updated by: Amgen

A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Impact of Evolocumab on Major Cardiovascular Events in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke

This study will assess the effect of lowering low-density lipoprotein cholesterol (LDL-C) with evolocumab on major cardiovascular events in adults without a prior myocardial infarction (MI) or stroke who are at high risk of a cardiovascular event.

Study Overview

Status

Completed

Conditions

Coronary Heart Disease (CHD)

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

12301

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Argentina
- - Corrientes, Argentina, W3400AMZ
    - Instituto de Cardiologia de Corrientes Juana Francisca Cabral
  - Córdoba, Argentina, X5003DCE
    - Instituto Medico DAMIC - Fundacion Rusculleda
  - Salta, Argentina, A4400ANW
    - Cordis Sa
  - San Juan, Argentina, J5400ARW
    - Clínica El Castaño
  - San Luis, Argentina, D5702JRS
    - Instituto Cardiovascular San Luis
  - Santa Fe, Argentina, S3000FWO
    - Centro de Investigaciones Clínicas del Litoral
- Buenos Aires
  - Bahía Blanca, Buenos Aires, Argentina, B8000FTD
    - Instituto de Investigaciones Clinicas Bahia Blanca
  - CABA, Buenos Aires, Argentina, C1426ABP
    - Fundación Respirar
  - CABA, Buenos Aires, Argentina, C1023AAB
    - STAT Research
  - CABA, Buenos Aires, Argentina, C1027AAP
    - CINME - Centro de Investigaciones Metabolicas
  - CABA, Buenos Aires, Argentina, C1119ACN
    - Ciprec - Centro de Investigacion y Prevencion Cardiovascular
  - CABA, Buenos Aires, Argentina, C1406BOA
    - Consultorio Medico Dr Litvak Bruno
  - CABA, Buenos Aires, Argentina, C1407GTN
    - Centro de Especialidades Medicas - Cemedic
  - CABA, Buenos Aires, Argentina, C1425AGC
    - Centro Medico Laura Maffei
  - CABA, Buenos Aires, Argentina, C1425BNG
    - Cardiologia Palermo
  - CABA, Buenos Aires, Argentina, C1425DES
    - CEDIC - Centro de Investigacion Clinica
  - CABA, Buenos Aires, Argentina, C1426ABP
    - Centro Médico Dra de Salvo
  - Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1012AAR
    - Instituto de Investigaciones Metabólicas - IDIM
  - Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1093AAS
    - Hospital Universitario Fundacion Favaloro
  - Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1428ART
    - ICBA - Instituto Cardiovascular de Buenos Aires
  - Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1430CKE
    - Glenny Corp SA
  - Mar del Plata, Buenos Aires, Argentina, B7600FZN
    - Instituto de Investigaciones Clinicas Mar del Plata
  - Morón, Buenos Aires, Argentina, B1708EPE
    - Ciad - Consultorio Integral de Atencion al Diabetico
  - Ramos Mejía, Buenos Aires, Argentina, B1704ETD
    - DIM Clinica Privada
  - San Nicolás de los Arroyos, Buenos Aires, Argentina, B2900DMH
    - Instituto de Investigaciones Clinicas de San Nicolas
  - Zárate, Buenos Aires, Argentina, B2800DGH
    - Instituto de Investigaciones Clínicas Zarate
- Córdoba Province
  - Córdoba, Córdoba Province, Argentina, 5000
    - Clinica Privada del Prado
  - Villa María, Córdoba Province, Argentina, X5900JKA
    - Clinica Fusavim Privada SRL
- La Pampa Province
  - Santa Rosa, La Pampa Province, Argentina, 6300
    - Sanatorio Santa Rosa Srl
- Santa Fe Province
  - Rosario, Santa Fe Province, Argentina, 2000
    - Instituto de Investigaciones Clínicas Rosario-Sanatorio Delta
  - Rosario, Santa Fe Province, Argentina, 2000
    - Sanatorio Plaza
- Tucumán Province
  - San Miguel de Tucumán, Tucumán Province, Argentina, 4000
    - Centro Modelo de Cardiologia
  - San Miguel de Tucumán, Tucumán Province, Argentina, 4000
    - Clinical Mayo de Urgencias Medicas Cruz Blanca SRL
Australia
- - Woolloongabba, Australia, 4102
    - Dr Heart Pty Ltd
- Australian Capital Territory
  - Garran, Australian Capital Territory, Australia, 2605
    - Canberra Hospital
- New South Wales
  - Camperdown, New South Wales, Australia, 2050
    - Royal Prince Alfred Hospital
  - Liverpool, New South Wales, Australia, 2170
    - Liverpool Hospital
  - Maroubra, New South Wales, Australia, 2035
    - Australian Clinical Research Network
- Queensland
  - Auchenflower, Queensland, Australia, 4066
    - Heartcare Partners
  - Bundaberg, Queensland, Australia, 4670
    - Bundaberg Cardiology
  - Fortitude Valley, Queensland, Australia, 4006
    - Holdsworth House Medical Brisbane
  - Milton, Queensland, Australia, 4064
    - Core Research Group Pty Ltd
- South Australia
  - Adelaide, South Australia, Australia, 5000
    - Royal Adelaide Hospital
  - Adelaide, South Australia, Australia, 5000
    - Heart and Vascular Research
  - Ashford, South Australia, Australia, 5035
    - SA Heart
  - Leabrook, South Australia, Australia, 5068
    - Adelaide Cardiology Practice - Leabrook Clinic
- Tasmania
  - Hobart, Tasmania, Australia, 7000
    - Royal Hobart Hospital
- Victoria
  - Berwick, Victoria, Australia, 3806
    - HeartCare Victoria - Berwick
  - Clayton, Victoria, Australia, 3168
    - Monash Medical Centre
  - Epping, Victoria, Australia, 3076
    - The Cardiologists Proprietary Limited
  - Geelong, Victoria, Australia, 3220
    - Barwon Health Geelong Hospital
  - Ringwood, Victoria, Australia, 3134
    - GenesisCare Ringwood
- Western Australia
  - Bentley, Western Australia, Australia, 6102
    - Curtin University Centre of Clinical Research and Education
  - Joondalup, Western Australia, Australia, 5068
    - HeartCare Western Australia - Joondalup
  - Murdoch, Western Australia, Australia, 6150
    - Fiona Stanley Hospital
Austria
- - Feldkirch, Austria, 6800
    - Landeskrankenhaus Feldkirch
  - Graz, Austria, 8036
    - Medizinische Universitaet Graz
  - Innsbruck, Austria, 6020
    - Medizinische Universitaet Innsbruck
  - Klagenfurt, Austria, 9020
    - Klinikum Klagenfurt am Woerthersee
  - Linz, Austria, 4010
    - Ordensklinikum Linz Barmherzige Schwestern
  - Vienna, Austria, 1160
    - Klinik Ottakring
  - Vienna, Austria, 1030
    - Klinik Landstrasse
  - Vienna, Austria, 1090
    - Universitaetsklinikum Allgemeines Krankenhaus Wien
  - Vienna, Austria, 1130
    - Klinik Hietzing
  - Vienna, Austria, 1060
    - Zentrum fuer klinische Studien - Dr Hanusch GmbH
Belgium
- - Aalst, Belgium, 9300
    - Algemeen Stedelijk Ziekenhuis Aalst
  - Aalst, Belgium, 9300
    - Onze Lieve Vrouw Ziekenhuis - campus Aalst
  - Antwerp, Belgium, 2020
    - Ziekenhuis Netwerk Antwerpen Middelheim
  - Antwerp, Belgium, 2060
    - Ziekenhuis Netwerk Antwerpen Stuivenberg
  - Brussels, Belgium, 1200
    - Universite Catholique de Louvain Cliniques Universitaires Saint Luc
  - Dendermonde, Belgium, 9200
    - AZ Sint Blasius
  - Ghent, Belgium, 9000
    - Algemeen Ziekenhuis Sint Lucas
  - Gozée, Belgium, 6534
    - Medif sprl
  - Ham, Belgium, 3945
    - Dokter Mortelmans bvba
  - Hasselt, Belgium, 3500
    - Jessa Ziekenhuis - Campus Virga Jesse
  - Leuven, Belgium, 3000
    - Universitair Ziekenhuis Leuven - Campus Gasthuisberg
  - Linkebeek, Belgium, 1630
    - Medilink sprl
  - Mons, Belgium, 7000
    - Centre Hospitalier Universitair Ambroise Pare
  - Overpelt, Belgium, 3900
    - Maria Ziekenhuis Noord-Limburg
  - Tessenderlo, Belgium, 3980
    - Testumed vzw
Brazil
- - Rio de Janeiro, Brazil, 20241-180
    - IBPCLIN Instituto Brasil de Pesquisa Clinica
  - São Paulo, Brazil, 05403-000
    - Instituto do Coracao do Hospital das Clinicas da Faculdade de medicina da Universidade de Sao Paulo
- Ceará
  - Fortaleza, Ceará, Brazil, 60430-350
    - Centro de Pesquisas em Diabetes e Doencas Endocrino Metabolicas
- Federal District
  - Brasília, Federal District, Brazil, 71625-175
    - Centro de Pesquisa Clinica do Brasil
- Minas Gerais
  - Belo Horizonte, Minas Gerais, Brazil, 30150-240
    - Cardresearch Cardiologia Assistencial de Pesquisa
  - Belo Horizonte, Minas Gerais, Brazil, 31110-580
    - Fundação Hospitalar São Francisco de Assis
  - Uberlândia, Minas Gerais, Brazil, 38411-186
    - Eurolatino Pesquisas Medicas
- Paraná
  - Campina Grande do Sul, Paraná, Brazil, 83430-000
    - Sociedade Hospitalar Angelina Caron
  - Curitiba, Paraná, Brazil, 80045-170
    - Quanta Diagnosticos e Terapia
  - Curitiba, Paraná, Brazil, 80230-130
    - Puc Trials - Núcleo de Pesquisa Clínica da Escola de Medicina da Pucpr/Epicenter
  - Curitiba, Paraná, Brazil, 80730-150
    - Núcleo de Pesquisa Clinica
- Rio Grande do Sul
  - Porto Alegre, Rio Grande do Sul, Brazil, 90610-000
    - Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul
  - Porto Alegre, Rio Grande do Sul, Brazil, 91350-200
    - Hospital Nossa Senhora da Conceicao
  - Porto Alegre, Rio Grande do Sul, Brazil, 90035-903
    - Núcleo de Pesquisa em Cirurgia Vascular
- Santa Catarina
  - Blumenau, Santa Catarina, Brazil, 89020-430
    - AngioCor Blumenau
- São Paulo
  - Campinas, São Paulo, Brazil, 13060-080
    - Instituto de Pesquisa Clinica de Campinas
  - Campinas, São Paulo, Brazil, 13010-001
    - Centro Especializado em Cardiologia
  - Marília, São Paulo, Brazil, 17515-000
    - Instituto do Coracao de Marília
  - São José do Rio Preto, São Paulo, Brazil, 15090-000
    - Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto
  - São Paulo, São Paulo, Brazil, 01228-200
    - Centro de Pesquisas Clinicas Cpclin
Bulgaria
- - Burgas, Bulgaria, 8000
    - Ambulatory for special outpatient medical aid in Cardiology-Private Practice Dr Elena Dotcheva EOOD
  - Haskovo, Bulgaria, 6300
    - Multiprofile Hospital for Active Treatment - Haskovo AD
  - Pernik, Bulgaria, 2300
    - Specialty Hospital for Active treatment in Cardiology Sveti Georgi - Pernik OOD
  - Pleven, Bulgaria, 5800
    - Medical Center Medconsult OOD
  - Pleven, Bulgaria, 5800
    - University Multiprofile Hospital for Active Treatment Dr Georgi Stranski EAD
  - Plovdiv, Bulgaria, 4001
    - University Multiprofile Hospital for Active Treatment Sveti Georgi EAD
  - Plovdiv, Bulgaria, 4003
    - Multiprofile Hospital for Active Treatment- Medical Complex- Sveti Ivan Rilski EOOD
  - Sofia, Bulgaria, 1527
    - University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna - ISUL EAD
  - Sofia, Bulgaria, 1233
    - National Multiprofile Transport Hospital Tzar Boris III
  - Sofia, Bulgaria, 1233
    - Fifth Multiprofile Hospital for Active Treatment - Sofia EAD
  - Sofia, Bulgaria, 1309
    - Medical Center for Specialized Medical Care of Cardiovascular Diseases OOD
  - Sofia, Bulgaria, 1407
    - Acibadem City Clinic Multiprofile Hospital for Active Treatment Tokuda EAD
  - Sofia, Bulgaria, 1407
    - Medical Center Excelsior OOD
  - Sofia, Bulgaria, 1606
    - University Multiprofile Hospital for Active Treatment and Emergency Medicine N I Pirogov EAD
  - Sofia, Bulgaria, 1680
    - Diagnostic-Consultative Center Convex EOOD
  - Sofia, Bulgaria, 1680
    - Medical center Kalimat EOOD
  - Sofia, Bulgaria, 1750
    - Multiprofile Hospital for Active Treatment Sveta Anna Sofia AD
  - Stara Zagora, Bulgaria, 6000
    - Medical Center Orpheus OOD
  - Veliko Tarnovo, Bulgaria, 5002
    - Multiprofile Regional Hospital for Active Treatment Dr Stefan Cherkezov AD
Canada
- Alberta
  - Calgary, Alberta, Canada, T2H 2G4
    - LMC Clinical Research Incorporated
- British Columbia
  - Surrey, British Columbia, Canada, V3V 0C6
    - SMH Cardiology Clinical Trials Incorporated
  - Vancouver, British Columbia, Canada, V5Y 3W2
    - Dr T G Elliott Incorporated - BC Diabetes
- Manitoba
  - Winnipeg, Manitoba, Canada, R3C 0N2
    - Winnipeg Clinic
- New Brunswick
  - Moncton, New Brunswick, Canada, E1G 1A7
    - G A Research Associates Limited
- Newfoundland and Labrador
  - Mount Pearl, Newfoundland and Labrador, Canada, A1N 1W7
    - Commonwealth Medical Clinic
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 3A7
    - Queen Elizabeth II Health Sciences Centre, Halifax Infirmary
- Ontario
  - Ajax, Ontario, Canada, L1Z 0B1
    - Heart Health Institute
  - Barrie, Ontario, Canada, L4N 7L3
    - LMC Clinical Research Incorporated
  - Brampton, Ontario, Canada, L6S 0C6
    - LMC Clinical Research Incorporated
  - Brampton, Ontario, Canada, L6Z 4N5
    - Brampton Clinical Trials
  - Concord, Ontario, Canada, L4K 4M2
    - LMC Clinical Research Incorporated Thornhill
  - Etobicoke, Ontario, Canada, M9R 4E1
    - LMC Clinical Research Incorporated
  - Hamilton, Ontario, Canada, L8L 2X2
    - Hamilton Health Sciences Hamilton General Hospital
  - London, Ontario, Canada, N6G 2M1
    - Western Centre for Public Health and Family Medicine - Western University
  - Markham, Ontario, Canada, L3P 7P2
    - My Endo Diabetes and Endocrinology Center
  - Nepean, Ontario, Canada, K2J 0V2
    - LMC Clinical Research Incorporated
  - Newmarket, Ontario, Canada, L3Y 5G8
    - SKDS Research Incorporated
  - Newmarket, Ontario, Canada, L3Y 2P6
    - Partners in Advanced Cardiac Evaluation
  - Oakville, Ontario, Canada, L6K 3W7
    - Oakville Cardiovascular Research
  - Oshawa, Ontario, Canada, L1J 2K1
    - Dr James Cha
  - Peterborough, Ontario, Canada, K9J 0B2
    - Kawartha Cardiology Clinical Trials
  - Sarnia, Ontario, Canada, N7T 4X3
    - Bluewater Clinical Research Group Incorporated
  - Scarborough Village, Ontario, Canada, M1B 4Z8
    - Heart Health Institute Research Incorporated
  - Scarborough Village, Ontario, Canada, M1B 5N1
    - Corcare Cardiovascular Research
  - Toronto, Ontario, Canada, M5S 1B2
    - Womens College Hospital
  - Toronto, Ontario, Canada, M6B 3H7
    - North York Diagnostic and Cardiac Centre
  - Weston, Ontario, Canada, M9N 1W4
    - Office of Dr Louis Yao
- Quebec
  - Chicoutimi, Quebec, Canada, G7H 7K9
    - Ecogene-21
  - Lévis, Quebec, Canada, G6W 0M5
    - Manna Research Incorporated
  - Montreal, Quebec, Canada, H2W 1R7
    - Institut de recherches cliniques de Montreal
  - Montreal, Quebec, Canada, H3G 1A4
    - McGill University Health Centre - Montreal General Hospital
  - Montreal, Quebec, Canada, H1T 3Y7
    - Clinique Sante Cardio MC
  - Montreal, Quebec, Canada, H4A 3T2
    - Applied Medical Informatics Research Incorporated
  - Québec, Quebec, Canada, G1V 4W2
    - Clinique des Maladies Lipidiques de Quebec Incorporated
  - Saint-Jérôme, Quebec, Canada, J7Z 5T3
    - Centre intégré de santé et de services sociaux (CISSS) des Laurentides - Unité de recherche clini
Czechia
- - Benátky nad Jizerou, Czechia, 294 71
    - MUDr Igor Karen
  - Beroun, Czechia, 266 01
    - Jessenia as, Nemocnice Beroun
  - Beroun, Czechia, 266 01
    - Medicentrum Beroun sro
  - Brandýs nad Labem, Czechia, 250 01
    - Medicus Services sro
  - Brno, Czechia, 625 00
    - Fakultní nemocnice Brno
  - Brno, Czechia, 636 00
    - Vojenska nemocnice Brno
  - Brno, Czechia, 602 00
    - Amkardia sro
  - Brno, Czechia, 602 00
    - CCR Brno sro
  - Brno, Czechia, 603 00
    - Centrum pro zdravi sro
  - Brno, Czechia, 612 00
    - Kardiologicka ambulance Brno sro
  - Brno, Czechia, 638 00
    - prof MUDr Lubomir Elbl, CSc, Kardiologicka ambulance
  - Broumov, Czechia, 550 01
    - Edumed sro, Kardiologicka ambulance
  - Havirov - Mesto, Czechia, 736 01
    - Dika centrum sro
  - Hodonín, Czechia, 695 01
    - Clinical Trial Center Hodonin sro
  - Holešov, Czechia, 769 01
    - Kardio Holesov sro
  - Hradec Králové, Czechia, 500 02
    - MUDr Ladislava Harrerova, kardiologicka ordinace
  - Karlovy Vary, Czechia, 360 01
    - Karlovarska krajska nemocnice
  - Kladno, Czechia, 272 59
    - Oblastni nemocnice Kladno as
  - Klatovy IV, Czechia, 339 01
    - Kardio Michal Cepelak sro
  - Kolin III, Czechia, 280 02
    - Oblastni nemocnice Kolin as
  - Liberec, Czechia, 460 63
    - Krajska nemocnice Liberec as
  - Louny, Czechia, 440 01
    - KardioBusak sro
  - Ludgeřovice, Czechia, 747 14
    - Kardio Pudich s.r.o.
  - Milevsko, Czechia, 399 01
    - Vseobecna intermi ambulance sro
  - Mladá Boleslav, Czechia, 293 01
    - MUDr Zbynek Kosek, kardiologicka ambulance sro
  - Mohelnice, Czechia, 789 85
    - Pozdisek sro, Kardiologicka ambulance
  - Ostrava, Czechia, 702 00
    - CCR Ostrava sro
  - Ostrava, Czechia, 728 80
    - Mestska nemocnice Ostrava
  - Ostrava - Poruba, Czechia, 708 00
    - Benedor sro - Kardiologicka, cevni a interni ambulance
  - Ostrava-Dubina, Czechia, 700 30
    - Kardiologicka a Angiologicka Ambulance
  - Pardubice, Czechia, 530 02
    - Center for Clinical Research Pardubice, sro
  - Pardubice, Czechia, 532 03
    - Nemocnice Pardubickeho kraje as
  - Pilsen, Czechia, 310 01
    - Kardiologie v sadech sro
  - Prague, Czechia, 128 08
    - Vseobecna fakultni nemocnice v Praze
  - Prague, Czechia, 140 59
    - Thomayerova nemocnice
  - Prague, Czechia, 150 06
    - Fakultni nemocnice v Motole
  - Prague, Czechia, 198 00
    - Endokrinologie Cerny Most sro
  - Prague, Czechia, 149 00
    - Milan Kvapil sro
  - Prague, Czechia, 101 00
    - Ordinace pro choroby srdce a cev
  - Prague, Czechia, 110 00
    - Diabet2 sro
  - Prague, Czechia, 130 00
    - CCR Prague sro
  - Prague, Czechia, 158 00
    - Interni a kardiologicka ordinace
  - Praha 10 - Zabehlice, Czechia, 106 00
    - Kardiologie Cor sro
  - Praha 5 - Smichov, Czechia, 150 00
    - Kardiologicke centrum MUDr Janky Skrobakove sro
  - Přerov, Czechia, 750 02
    - Kardio Vaclavik sro, Interni a kardiologicka ambulance
  - Rychnov nad Kněžnou, Czechia, 516 01
    - Vestra Clinics sro
  - Svitavy, Czechia, 568 25
    - Nemocnice Pardubickeho kraje as, Svitavska nemocnice
  - Teplice, Czechia, 415 01
    - AeskuLab ks, Lipidova poradna
  - Třinec, Czechia, 739 61
    - Nemocnice Podlesi as
  - Uherské Hradiště, Czechia, 686 01
    - Interni ambulance
  - Uherské Hradiště, Czechia, 686 01
    - Clinical Trials Service sro
  - Zlín, Czechia, 760 01
    - Lekarsky dum Ormiga
  - Znojmo, Czechia, 669 02
    - KIGE sro
  - České Budějovice, Czechia, 370 11
    - Cevni centrum Ceske Budejovice sro
Denmark
- - Aalborg, Denmark, 9000
    - Aalborg Hospital
  - Aalborg, Denmark, 9000
    - Center for Clinical and Basic Research Aalborg
  - Aarhus N, Denmark, 8200
    - Aarhus Universitetshospital
  - Ballerup Municipality, Denmark, 2750
    - Centre for Clinical and Basic Research Ballerup
  - Esbjerg, Denmark, 6700
    - Sydvestjysk Sygehus
  - Herlev, Denmark, 2730
    - Sanos Clinic
  - Herlev, Denmark, 2730
    - Steno Diabetes Center
  - Herning, Denmark, 7400
    - Regionhospitalet Herning
  - Hillerød, Denmark, 3400
    - Hillerod Hospital
  - Kolding, Denmark, 6000
    - Kolding Sygehus
  - København S, Denmark, 2300
    - Amager Hospital
  - København Ø, Denmark, 2100
    - Rigshospitalet Kobenhavn
  - Silkeborg, Denmark, 8600
    - Regionshospitalet Silkeborg
  - Svendborg, Denmark, 5700
    - Svendborg Sygehus
  - Vejle, Denmark, 7100
    - Center for Clinical and Basic Research Vejle
  - Viborg, Denmark, 8800
    - Regionshospitalet Viborg
Estonia
- - Pärnu, Estonia, 80014
    - Liina Viitas OÜ
  - Tallinn, Estonia, 13419
    - North Estonia Medical Centre Foundation
  - Tallinn, Estonia, 13419
    - Dr Arvo Rosenthal LLC
  - Tallinn, Estonia, 10128
    - Center for Clinical and Basic Research Tallinn
Finland
- - Helsinki, Finland, 00029
    - Helsinki University Central Hospital
  - Helsinki, Finland, 00100
    - GERI-MED Oy
  - Joensuu, Finland, 80210
    - Pohjois-Karjalan keskussairaala
  - Jyväskylä, Finland, 40620
    - StudyCor Oy
  - Jyväskylä, Finland, 40100
    - Terveystalo Jyvaskyla
  - Kuopio, Finland, 70210
    - University of Eastern Finland
  - Kuopio, Finland, 70100
    - Satucon Oy/Kuopion tyoterveys
  - Oulu, Finland, 90220
    - Oulu University Hospital
  - Oulu, Finland, 90029
    - Oulu University Hospital
  - Tampere, Finland, 33520
    - Tampere University Hospital
  - Turku, Finland, 20100
    - Terveystalo Pulssi
France
- - Amiens, France, 80054
    - Centre Hospitalier Universitaire Amiens - Hopital Sud
  - Bron, France, 69677
    - Hospices Civils de Lyon Groupement Hospitalier Est, Hopital Louis Pradel
  - Caen, France, 14033
    - Centre Hospitalier Universitaire de Caen - Hôpital Côte de Nacre
  - Corbeil-Essonnes, France, 91106
    - Centre hospitalier Sud Francilien
  - Dijon, France, 21079
    - Centre Hospitalier Universitaire de Dijon - Hopital Francois Mitterrand
  - Grenoble, France, 38700
    - Centre Hospitalier Universitaire de Grenoble - Hopital Nord Michallon
  - Grenoble, France, 38000
    - Groupement Hospitalier Mutualiste
  - Le Chesnay, France, 78150
    - Centre Hospitalier de Versailles - Hopital Andre Mignot
  - Le Coudray, France, 28630
    - Hopital Louis Pasteur
  - Lille, France, 59037
    - Centre Hospitalier Régional Universitaire de Lille - Institut Coeur Poumon
  - Lyon Cédex 3, France, 69437
    - Centre Hospitalier Universitaire de Lyon - Hopital Edouard Herriot
  - Marseille, France, 13285
    - Höpital Saint-Joseph
  - Marseille, France, 13385
    - Centre Hospitalier Universitaire de Marseille - Hôpital de la Timone
  - Montpellier, France, 34295
    - Centre Hospitalier Régional Universitaire de Montpellier - Hôpital Arnaud de Villeneuve
  - Nantes, France, 44093
    - Centre Hospitalier Universitaire de Nantes - Hopital Guillaume et Rene Laennec
  - Nice, France, 06002
    - Centre Hospitalier Universitaire de Nice - Hopital Pasteur
  - Nîmes, France, 30029
    - Centre Hospitalier Universitaire de Nîmes
  - Paris, France, 75015
    - Hôpital Européen Georges Pompidou
  - Paris, France, 75012
    - Hôpital Saint Antoine
  - Paris, France, 75018
    - Hopital Bichat Claude Bernard
  - Paris, France, 75013
    - Hopital Pitie-Salpetriere
  - Pau, France, 64000
    - Centre Hospitalier de Pau - Hôpital François Mitterrand
  - Rennes, France, 35033
    - Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou
  - Rouen, France, 76000
    - Clinique Saint Hilaire
  - Toulouse, France, 31076
    - Clinique Pasteur
  - Toulouse, France, 31059
    - Centre Hospitalier Universitaire de Toulouse - Hôpital Rangueil
  - Valenciennes, France, 59300
    - Polyclinique Vauban
Germany
- - Bad Krozingen, Germany, 79189
    - Universitaets-Herzzentrum Freiburg - Bad Krozingen
  - Bad Neuheim, Germany, 61231
    - Kerckhoff-Klinik Forschungs GmbH
  - Berlin, Germany, 10787
    - Klinische Forschung Berlin GbR
  - Berlin, Germany, 13353
    - Charite Universitätsmedizin Berlin, Charité Campus Virchow-Klinikum
  - Bremen, Germany, 28277
    - Kardiologisch - Angiologische Praxis - Herzzentrum Bremen
  - Dortmund, Germany, 44137
    - Sankt-Johannes-Hospital
  - Dresden, Germany, 01277
    - Cardiologicum Dresden und Pirna
  - Dresden, Germany, 01279
    - Diabetologische Gemeinschaftspraxis Dr Schaper und Dr Faulmann
  - Dresden, Germany, 01307
    - Universitaetsklinikum Carl Gustav Carus, Medizinische Klinik und Poliklinik III
  - Frankfurt am Main, Germany, 60590
    - Klinikum und Fachbereich Medizin Johann Wolfgang Goethe-Universität Frankfurt am Main
  - Frankfurt am Main, Germany, 60596
    - Clin Phenomics GmbH Co KG
  - Fulda, Germany, 36037
    - Medizinisches Versorgungszentrum im Altstadt-Carree Fulda
  - Hamburg, Germany, 22041
    - Cardiologicum Hamburg
  - Heidelberg, Germany, 69120
    - Universitätsklinikum Heidelberg
  - Kassel, Germany, 34121
    - Ambulantes Herzzentrum Kassel
  - Leipzig, Germany, 4103
    - Universitätsklinikum Leipzig
  - Magdeburg, Germany, 39120
    - Otto Von Guericke Universität Magdeburg
  - Mainz, Germany, 55131
    - Johannes Gutenberg Universitaet Mainz
  - Mannheim, Germany, 68167
    - Universitätsklinikum Mannheim
  - Markleeberg, Germany, 04416
    - Praxis Doktor Jens Taggeselle
  - München, Germany, 80636
    - Deutsches Herzzentrum München des Freistaates Bayern
  - München, Germany, 80638
    - Herz Gefaess Zentrum Nymphenburg
  - Münster, Germany, 48149
    - Universitaetsklinikum Muenster
  - Papenburg, Germany, 26871
    - Kardiologische Gemeinschaftspraxis Papenburg
  - Potsdam, Germany, 14467
    - Klinikum Ernst von Bergmann gGmbH
  - Regensburg, Germany, 93053
    - Universitätsklinikum Regensburg
  - Rostock, Germany, 18059
    - CardioConsil GmbH
  - Singen, Germany, 78224
    - I Medizinische Klinik Gesundheitsverbund Landkreis Konstanz
  - Ulm, Germany, 89081
    - Universitätsklinikum Ulm
  - Villingen-Schwenningen, Germany, 78052
    - Nephrologisches Zentrum Villingen-Schwenningen
  - Witten, Germany, 58455
    - Forschungszentrum Ruhr
Greece
- - Athens, Greece, 11527
    - General Hospital of Athens Laiko
  - Athens, Greece, 15123
    - Hygeia Hospital
  - Athens, Greece, 11528
    - Alexandra Hospital
  - Athens, Greece, 11527
    - General Hospital of Athens Georgios Gennimatas
  - Athens, Greece, 10676
    - General Hospital of Athens Evaggelismos
  - Athens, Greece, 11521
    - Athens Naval Hospital
  - Athens, Greece, 11527
    - General Hospital of Athens Ippokrateio
  - Athens, Greece, 14233
    - Konstantopoulio - Agia Olga Hospital of Nea Ionia
  - Heraklion, Greece, 71110
    - University Hospital of Heraklion
  - Ioannina, Greece, 45500
    - University Hospital of Ioannina
  - Larissa, Greece, 41110
    - University Hospital of Larissa
  - Thessaloniki, Greece, 56403
    - Papageorgiou General Hospital of Thessaloniki
  - Thessaloniki, Greece, 54636
    - Ahepa University Hospital
  - Thessaloniki, Greece, 54636
    - General Hospital of Thessaloniki Ahepa
  - Thessaloniki, Greece, 57001
    - Interbalkan Medical Center
Hungary
- - Baja, Hungary, 6500
    - Lausmed Kft
  - Balatonfüred, Hungary, 8230
    - Allami Szivkorhaz Balatonfured
  - Balatonkeresztúr, Hungary, 8647
    - Balatonmariafurdo Kozseg Onkormanyzatanak Haziorvosi Rendeloje
  - Ballószög, Hungary, 6035
    - Med-Edu Bt
  - Berettyóújfalu, Hungary, 4100
    - Grof Tisza Istvan Korhaz
  - Budapest, Hungary, 1036
    - Obudai Egeszsegugyi Centrum Kft
  - Budapest, Hungary, 1204
    - Jahn Ferenc Del-pesti Korhaz es Rendelointezet
  - Budapest, Hungary, 1145
    - Uzsoki Utcai Korhaz
  - Budapest, Hungary, 1096
    - Gottsegen György Országos Kardiológiai Intézet
  - Budapest, Hungary, 1106
    - Bajcsy-Zsilinszky Kórház és Rendelőintézet
  - Budapest, Hungary, 1122
    - Semmelweis Egyetem
  - Budapest, Hungary, 1134
    - Magyar Honvedseg Egeszsegugyi Kozpont
  - Budapest, Hungary, 1023
    - Betegapolo Irgalmas Rend - Budai Irgalmasrendi Korhaz
  - Budapest, Hungary, 1033
    - Clinexpert Kft
  - Budapest, Hungary, 1085
    - Semmelweis Egyetem Városmajori Szív- és Érgyógyászati Klinika
  - Budapest, Hungary, 1148
    - Zugloi Egeszsegugyi Szolgalat
  - Békéscsaba, Hungary, 5600
    - Dr Lakatos Ferenc Private Cardiology Practice
  - Debrecen, Hungary, 4032
    - Debreceni Egyetem Klinikai Kozpont
  - Eger, Hungary, 3300
    - Markhot Ferenc Oktatokorhaz es Rendelointezet
  - Gyula, Hungary, 5700
    - Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaz
  - Gyöngyös, Hungary, 3200
    - Bugat Pal Korhaz
  - Gyöngyös, Hungary, 3200
    - Pharma4 Trial Kft
  - Gödöllő, Hungary, 2100
    - Erzsebet Gondozohaz
  - Hatvan, Hungary, 3000
    - BKS Research Kft
  - Kalocsa, Hungary, 6300
    - Bacs-Kiskun Megyei Korhaz Szegedi Tudomanyegyetem Altalanos Orvostudomanyi Kar Oktato Korhaza
  - Komárom, Hungary, 2921
    - Selye János Kórház
  - Miskolc, Hungary, 3526
    - Borsod-Abaúj-Zemplén Megyei Központi Kórház és Egyetemi Oktatókórház
  - Miskolc, Hungary, 3529
    - CRU Hungary Kft
  - Pécs, Hungary, 7624
    - Pecsi Tudomanyegyetem Klinikai Kozpont
  - Sopron, Hungary, 9400
    - Soproni Erzsebet Oktato Korhaz es Rehabilitacios Intezet
  - Szeged, Hungary, 6725
    - Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont Altalanos Orvostudomanyi Kar
  - Szeged, Hungary, 6725
    - Szegedi Tudomanyegyetem Szent Gyorgyi Albert Klinikai Kozpont Altalanos Orvostudomanyi Kar
  - Szekszárd, Hungary, 7100
    - Tolna Megyei Balassa János Kórház
  - Szentes, Hungary, 6600
    - Csongrad Megyei Dr Bugyi Istvan Korhaz
  - Szolnok, Hungary, 5004
    - Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rendelointezet
  - Székesfehérvár, Hungary, 8000
    - Praxispont Belvarosi Maganegeszsegugyi Kozpont
  - Zalaegerszeg, Hungary, 8900
    - Belvarosi Egeszseghaz Kft
Iceland
- - Kopavogur, Iceland, 201
    - Hjartamidstodin
  - Reykjavik, Iceland, 101
    - Landspitali
Italy
- - Augusta, Italy, 96011
    - Ospedale Muscatello
  - Bergamo, Italy, 24127
    - Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII
  - Bologna, Italy, 40138
    - Azienda Ospedaliero Universitaria Di Bologna Policlinico S Orsola Malpighi
  - Catanzaro, Italy, 88100
    - Azienda Ospedaliero Universitaria Mater Domini
  - Chieti, Italy, 66100
    - Universita degli Studi Gabriele D Annunzio di Chieti e Pescara
  - Massa, Italy, 54100
    - Fondazione Toscana Gabriele Monasterio Ospedale del Cuore G Pasquinucci
  - Milan, Italy, 20138
    - Centro Cardiologico Monzino
  - Milan, Italy, 20132
    - Irccs Ospedale San Raffaele
  - Milan, Italy, 20162
    - Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
  - Pisa, Italy, 56100
    - Azienda Ospedaliero Universitaria Pisana
  - Pozzuoli, Italy, 80078
    - Presidio Ospedaliero Santa Maria delle Grazie
  - Roma, Italy, 00189
    - Azienda Ospedaliera Sant Andrea
  - Roma, Italy, 00128
    - Policlinico Universitario Campus Biomedico
  - San Donato Milanese, Italy, 20097
    - IRCCS Policlinico San Donato
  - Torino, Italy, 10126
    - Azienda Ospedaliera Città della Salute e della Scienza di Torino
  - Udine, Italy, 33100
    - Azienda Ospedaliero Universitaria Integrata di Udine
Latvia
- - Daugavpils, Latvia, 5417
    - Daugavpils Regional Hospital
  - Ogre, Latvia, 5001
    - Dace Teterovska Doctor Practice in Endocrinology
  - Ogre, Latvia, 5001
    - Inga Jasinkevica Cardiologist Practice
  - Riga, Latvia, 1002
    - Pauls Stradins Clinical University Hospital
  - Riga, Latvia, 1012
    - Outpatient clinic Veselibas Centrs 4
Lithuania
- - Alytus, Lithuania, 63200
    - Klinikiniai sprendimai, UAB
  - Kaunas, Lithuania, 50009
    - Hospital of Lithuanian University of Health Sciences Kaunas Clinics Public Institution
  - Kaunas, Lithuania, 49387
    - Klinikiniai sprendimai, UAB
  - Kaunas, Lithuania, 49456
    - Saules Seimos Medicinos Centras
  - Klaipėda, Lithuania, 91131
    - Kardiologijos ir reabilitacijos klinika, UAB
  - Vilnius, Lithuania, 08661
    - Vilnius University Hospital Santaros Clinic Public Institution
  - Šiauliai, Lithuania, 76231
    - Siauliai Republican Hospital, Public Institution
Mexico
- - Aguascalientes, Mexico, 20230
    - Centro de investigacion Cardiometabolica
  - Chihuahua City, Mexico, 31203
    - SCIENTIA Investigacion Clinica SC
- Mexico City
  - Cd de Mexico, Mexico City, Mexico, 06700
    - Clinstile SA de CV
- Nuevo León
  - Monterrey, Nuevo León, Mexico, 64460
    - Unidad Biomédica Avanzada Monterrey
- Querétaro
  - Querétaro City, Querétaro, Mexico, 76000
    - Centro de Estudios Clinicos de Queretaro
- Sinaloa
  - Culiacán, Sinaloa, Mexico, 80230
    - Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada SC
Netherlands
- - Alkmaar, Netherlands, 1815 JD
    - Noordwest ziekenhuisgroep
  - Almelo, Netherlands, 7609 PP
    - Ziekenhuisgroep Twente
  - Almere Stad, Netherlands, 1311 RL
    - Emotional Brain
  - Amersfoort, Netherlands, 3813 TZ
    - Meander Medisch Centrum
  - Amsterdam, Netherlands, 1105 AZ
    - Academisch Medisch Centrum
  - Amsterdam, Netherlands, 1091 AC
    - Onze Lieve Vrouwe Gasthuis
  - Amsterdam, Netherlands, 1061 AE
    - Onze Lieve Vrouwe Gasthuis
  - Apeldoorn, Netherlands, 7334 DZ
    - Gelre Ziekenhuis
  - Arnhem, Netherlands, 6815 AD
    - Rijnstate Ziekenhuis
  - Beverwijk, Netherlands, 1942 LE
    - Rode Kruis Ziekenhuis
  - Breda, Netherlands, 4818 CK
    - Amphia Ziekenhuis
  - Delft, Netherlands, 2625 AD
    - Reinier de Graaf Gasthuis
  - Deventer, Netherlands, 7416 SE
    - Deventer Ziekenhuis
  - Dirksland, Netherlands, 3247 BW
    - Van Weel Bethesda Ziekenhuis
  - Dordrecht, Netherlands, 3318 AT
    - Albert Schweitzer Ziekenhuis, Locatie Dordwijk
  - Dordrecht, Netherlands, 3318 AT
    - Albert Schweitzer Ziekenhuis location Dordwijk
  - Ede, Netherlands, 6716 RP
    - Ziekenhuis Gelderse Vallei
  - Eindhoven, Netherlands, 5623 EJ
    - Catharina Ziekenhuis
  - Emmen, Netherlands, 7824 AA
    - Treant Zorggroep, locatie Scheper ziekenhuis Emmen
  - Enschede, Netherlands, 7512 KZ
    - Medisch Spectrum Twente
  - Goes, Netherlands, 4462 RA
    - Admiraal de Ruyter Ziekenhuis
  - Gouda, Netherlands, 2803 HH
    - Groene Hart ziekenhuis
  - Groningen, Netherlands, 9728 NT
    - Martini Ziekenhuis
  - Harderwijk, Netherlands, 3844 DG
    - Sint Jansdal Ziekenhuis
  - Heerlen, Netherlands, 6419 PC
    - Zuyderland Medisch Centrum
  - Helmond, Netherlands, 5707 HA
    - Elkerliek Ziekenhuis
  - Hilversum, Netherlands, 1213 XZ
    - Tergooi
  - Hoogeveen, Netherlands, 7909 AA
    - Bethesda Diabetes Research Center
  - Hoorn, Netherlands, 1624 NP
    - Dijklander Ziekenhuis Hoorn
  - Leeuwarden, Netherlands, 8934 AD
    - Medisch Centrum Leeuwarden
  - Leiden, Netherlands, 2333 ZA
    - Leids Universitair Medisch Centrum
  - Meppel, Netherlands, 7943 KA
    - Isala Diaconessenhuis
  - Nieuwegein, Netherlands, 3435 CM
    - Sint Antonius Ziekenhuis, locatie Nieuwegein
  - Nijmegen, Netherlands, 6525 GA
    - Radboudumc
  - Nijmegen, Netherlands, 6532 SZ
    - Canisius-Wilhelmina Ziekenhuis
  - Rotterdam, Netherlands, 3083 AN
    - Ikazia Ziekenhuis
  - Rotterdam, Netherlands, 3079 DZ
    - Maasstad Ziekenhuis
  - Rotterdam, Netherlands, 3045 PM
    - Franciscus Gasthuis
  - Rotterdam, Netherlands, 3067 GJ
    - Praktijk Soerland
  - Schiedam, Netherlands, 3118 JH
    - Franciscus Vlietland
  - Sneek, Netherlands, 8601 ZR
    - D&A Research and Genetics
  - The Hague, Netherlands, 2545 AA
    - Haga Ziekenhuis
  - The Hague, Netherlands, 2572 GM
    - Huisartsenpraktijk Rambharose
  - Tiel, Netherlands, 4002 WP
    - Ziekenhuis Rivierenland
  - Tilburg, Netherlands, 5042 AD
    - Elisabeth-Tweesteden Ziekenhuis
  - Uden, Netherlands, 5406 PT
    - Ziekenhuis Bernhoven
  - Utrecht, Netherlands, 3584 CX
    - Universitair Medisch Centrum Utrecht
  - Utrecht, Netherlands, 3582 KE
    - Diakonessenhuis
  - Venlo, Netherlands, 5912 BL
    - Viecuri Medisch Centrum
  - Zaandam, Netherlands, 1502 DV
    - Zaans Medisch Centrum
  - Zwijndrecht, Netherlands, 3331 LZ
    - Albert Schweitzer Ziekenhuis
  - Zwijndrecht, Netherlands, 3334 SB
    - Dokters van Nederhoven
  - Zwolle, Netherlands, 8025 AB
    - Isala Klinieken
Poland
- - Bydgoszcz, Poland, 85-094
    - Szpital Uniwersytecki nr 1 im dr Antoniego Jurasza w Bydgoszczy
  - Chrzanów, Poland, 32-500
    - American Heart of Poland Sa Malopolskie Centrum Sercowo-Naczyniowe PAKS - Chrzanow
  - Gdansk, Poland, 80-219
    - Uniwersyteckie Centrum Kliniczne
  - Gdansk, Poland, 80-462
    - Copernicus Podmiot Leczniczy Sp zoo
  - Gdynia, Poland, 81-394
    - NZOZ Srodmiescie Spzoo
  - Gdynia, Poland, 81-472
    - Marek Piepiorka Gabinet Kardiologiczno-Internistyczny
  - Giżycko, Poland, 11-500
    - Spolka Cywilna Medicina
  - Grodzisk Mazowiecki, Poland, 05-825
    - Samodzielny Publiczny Specjalistyczny Szpital Zachodni im swietego Jana Pawla II
  - Józefów, Poland, 05-410
    - Biokinetica SA
  - Katowice, Poland, 40-081
    - Centrum Medyczne Pratia Katowice
  - Kielce, Poland, 25-525
    - Specjalistyczna Poradnia Kardiologiczna i Nadcisnienia Tetniczego Beata Wozakowska-Kaplon
  - Kielce, Poland, 25-736
    - Wojewodzki Szpital Zespolony w Kielcach
  - Krakow, Poland, 30-082
    - Ewa Mirek-Bryniarska Specjalistyczna Praktyka Lekarska
  - Krakow, Poland, 31-135
    - Zespol Przychodni Specjalistycznych Diab-End-Cor Sp z oo
  - Krakow, Poland, 31-501
    - Krakowskie Centrum Medyczne Spzoo
  - Krakow, Poland, 31-514
    - CARINTART Sp zoo Krakowskie Centrum Diagnostyczno-Kliniczne
  - Krosno, Poland, 38-400
    - Intercard Spzoo Centrum Kardiologii Inwazyjnej Elektroterapii i Angiologii w Krosnie
  - Lodz, Poland, 93-338
    - Instytut Centrum Zdrowia Matki Polki
  - Lodz, Poland, 91-347
    - Wojewodzki Specjalistyczny Szpital im dr Wladyslawa Bieganskiego w Lodzi
  - Lubin, Poland, 59-300
    - Miedziowe Centrum Zdrowia Spolka Akcyjna
  - Lublin, Poland, 20-362
    - KO-MED Centra Kliniczne Lublin II
  - Lublin, Poland, 20-044
    - CenterMed Lublin Spzoo
  - Lublin, Poland, 20-078
    - Clinical Best Solutions Sp zoo Spolka Komandytowa Gabinet Lekarski
  - Lublin, Poland, 20-857
    - NZOZ Twoja Przychodnia Spzoo
  - Miechów, Poland, 32-200
    - Szpital Swietej Anny w Miechowie
  - Nowy Targ, Poland, 34-400
    - Podhalanski Szpital Specjalistyczny im Jana Pawla II w Nowym Targu
  - Piaseczno, Poland, 05-500
    - Centrum Medyczne Pulawska spzoo Centrum Medyczne Pulawska NZOZ
  - Poznan, Poland, 60-848
    - Clinical Research Center Spzoo Medic-R Spolka Komandytowa
  - Puławy, Poland, 24-100
    - KO-MED Centra Kliniczne Spzoo KO-MED Centra Kliniczne Pulawy
  - Płock, Poland, 09-402
    - NZOZ Specjalistyczna Przychodnia Lekarska Medikard
  - Ruda Śląska, Poland, 41-709
    - NZOZ Przychodnia Specjalistyczna Andrzej Wittek Henryk Rudzki spolka jawna
  - Siedlce, Poland, 08-110
    - Clinical Best Solutions Spolka z ograniczona odpowiedzialnoscia Spolka komandytowa
  - Skierniewice, Poland, 96-100
    - ETG Network Spzoo
  - Staszów, Poland, 28-200
    - KO-MED Centra Kliniczne Spzoo KO-MED Centra Kliniczne Staszow
  - Szczecin, Poland, 70-506
    - Indywidualna Specjalistyczna Praktyka Lekarska
  - Tarnów, Poland, 33-100
    - Centrum Szybkiej Diagnostyki Kardiologicznej Kardiomed M Zabowka E Zabowka Spolka cywilna
  - Torun, Poland, 87-100
    - Medical Trials Institute Spzoo
  - Torun, Poland, 87-100
    - Prywatne Centrum Kardiologii
  - Torun, Poland, 87-100
    - Wojewodzki Szpital Zespolony im Ludwika Rydygiera w Toruniu
  - Warsaw, Poland, 02-957
    - Instytut Psychiatrii i Neurologii
  - Warsaw, Poland, 01-868
    - Centrum Medyczne Pratia Warszawa
  - Warsaw, Poland, 01-518
    - Centrum Medyczne Amed Warszawa Zoliborz
  - Warsaw, Poland, 02-793
    - Clinical Best Solutions Sp zoo Spolka komandytowa
  - Warsaw, Poland, 04-073
    - Szpital Grochowski imienia Doktora medycyny Rafala Masztaka Spzoo
  - Wroclaw, Poland, 51-162
    - Centrum Badan Klinicznych Piotr Napora lekarze spolka partnerska
  - Wroclaw, Poland, 50-088
    - Futuremeds spolka z ograniczona odpowiedzialnoscia
  - Wroclaw, Poland, 50-315
    - Centrum Kardiologiczne Pro Corde Spzoo Centrum Kardiologicne Pro Corde Wroclaw
  - Węgrów, Poland, 07-100
    - Samodzielny Publiczny Zaklad Opieki Zdrowotnej w Wegrowie
  - Włocławek, Poland, 87-800
    - Medicor Plus Kardiolodzy Spzoo
  - Zamość, Poland, 22-400
    - KO-MED Centra Kliniczne Spzoo KO-MED Centra Kliniczne Zamosc
  - Łęczna, Poland, 21-010
    - Samodzielny Publiczny Zakład Opieki Zdrowotnej w Lecznej
  - Świdnik, Poland, 21-040
    - Tomasz Blicharski Lubelskie Centrum Diagnostyczne
Portugal
- - Almada, Portugal, 2801-951
    - Hospital Garcia de Orta, EPE
  - Aveiro, Portugal, 3814-501
    - Centro Hospitalar do Baixo Vouga, EPE - Hospital Infante Dom Pedro
  - Carnaxide, Portugal, 2790-134
    - Centro Hospitalar de Lisboa Ocidental, EPE - Hospital de Santa Cruz
  - Coimbra, Portugal, 3000-075
    - Centro Hospitalar E Universitario de Coimbra EPE
  - Faro, Portugal, 8000-386
    - Hospital de Faro, EPE
  - Guimarães, Portugal, 4835-044
    - Hospital da Senhora da Oliveira, Guimaraes, EPE
  - Lisbon, Portugal, 1250-189
    - Associação Protectora dos Diabéticos de Portugal
  - Matosinhos Municipality, Portugal, 4464-513
    - Unidade Local de Saúde de Matosinhos - Hospital Pedro Hispano
  - Viseu, Portugal, 3500-093
    - Hospital Casa de Saude Sao Mateus
Romania
- - Brasov, Romania, 500283
    - SC Centrul Medical de Diagnostic si Tratament Ambulator Neomed S.R.L
  - Bucharest, Romania, 050098
    - Spitalul Universitar de Urgenta Bucuresti
  - Bucharest, Romania, 011461
    - Spitalul Clinic Universitar de Urgenta Elias
  - Bucharest, Romania, 022328
    - Institutul de Urgenţă pentru Boli Cardiovasculare "Prof. Dr. C. C. Iliescu",
  - Craiova, Romania, 200512
    - Cardiomed SRL
  - Iași, Romania, 700547
    - Consultmed SRL
  - Iași, Romania, 700732
    - SC Cardiomed SRL
  - Oradea, Romania, 410151
    - SC Endodigest SRL
  - Piteşti, Romania, 110438
    - Sc Sal Med Srl
  - Târgu Mureş, Romania, 540143
    - Cmi Dr Podoleanu Cristian
  - Târgu Mureş, Romania, 540142
    - Mediab SRL
Russia
- - Arkhangelsk, Russia, 163001
    - First City Clinical Hospital na E E Volosevich
  - Barnaul, Russia, 656038
    - NSHI Departmental Hospital at the station Barnaul of OJSC Russian Railways
  - Barnaul, Russia, 656055
    - Regional State Budget Health care Institution Altay Regional Cardiology Dispensary
  - Ivanovo, Russia, 153012
    - Regional Budget Healthcare Institution Cardiology Dispensary
  - Izhevsk, Russia, 426063
    - BHI of Republic Udmurtiya City clinical hospital 9 of Ministry of healthcare of Republic Udmurtiya
  - Kemerovo, Russia, 650002
    - FSBI Heart and Vessels Diseases complex problems Scientific Research Institution
  - Kirov, Russia, 610014
    - Kirov Regional State Budget Healthcare Institution Kirov City Clinical Hospital 1
  - Krasnodar, Russia, 350012
    - Regional Clinical Hospital 2 of the Ministry of Health Krasnodar region
  - Krasnodar, Russia, 350086
    - SBHI Scientific Research Institute Regional Clinical Hospital 1 named after S V Ochapovsky
  - Moscow, Russia, 101990
    - National Medical Research Center for Therapy and Preventive Medicine
  - Moscow, Russia, 111539
    - Moscow SBHI City Clinical Hospital 15 n a O M Filatov of Moscow Healthcare Department
  - Moscow, Russia, 117292
    - SBHI of Moscow City clinical hospital 64 of Moscow Healthcare department
  - Moscow, Russia, 121374
    - City Clinical Hospital named after Zhadkevich
  - Moscow, Russia, 121552
    - FSBI Russian Cardiology Research and Production Complex
  - Nizhny Novgorod, Russia, 603126
    - SBHI of Nizhny Novgorod region Nizhny Novgorod regional clinical hospital na N A Semashko
  - Novosibirsk, Russia, 630005
    - LLC RC Medical
  - Novosibirsk, Russia, 630047
    - SBHI of Novosibirsk Region City clinical hospital 1
  - Novosibirsk, Russia, 630089
    - FSBSI Scientific Research Institute of Therapy and preventive medicine
  - Omsk, Russia, 644018
    - Budget Healthcare Institution of Omsk region Medical-sanitary unit 9
  - Perm, Russia, 614097
    - Perm Regional Hospital for War Veterans
  - Ryazan, Russia, 390039
    - State Budget Institution of Ryazan Region Regional Clinical Hospital
  - Saint Petersburg, Russia, 190031
    - City Polyclinic 27
  - Saint Petersburg, Russia, 192283
    - Saint Petersburg State Budget Healthcare Institution City Polyclinic 109
  - Saint Petersburg, Russia, 192289
    - Saint Petersburg State Budget Healthcare Institution City Polyclinic 109
  - Saint Petersburg, Russia, 193312
    - City polyclinic 25 Nevsky district
  - Saint Petersburg, Russia, 195112
    - SBHI Medical and sports dispensary of Krasnogvardeisky district of Saint Petersburg
  - Saint Petersburg, Russia, 196601
    - Saint Petersburg SBHI City Hospital 38 named after N A Semashko
  - Saint Petersburg, Russia, 197341
    - Almazov National Medical Research Centre
  - Saint Petersburg, Russia, 199106
    - Saint Petersburg State Budget Healthcare Institution Pokrovskaya City Hospital
  - Saint Petersburg, Russia, 199178
    - LLC MART
  - Sait-Petersburg, Russia, 194044
    - LLC Medinef Clinic
  - Samara, Russia, 443070
    - Samara Regional Clinical Cardiology Dispensary
  - Saratov, Russia, 410054
    - Clinical Hospital named after S R Mirotvortsev
  - Smolensk, Russia, 214018
    - Regional State Budget Helthcare Institution Smolensk Regional Clinical Hospital
  - Sochi, Russia, 354057
    - State Budgetary Health Institution City Hospital 4 of the City of Sochi
  - Tomsk, Russia, 634012
    - FSBSI Tomsk National Research Medical Center of the Russian Academy of Sciences
  - Tyumen, Russia, 625023
    - Tyumen State Medical University
  - Tyumen, Russia, 625032
    - State Autonomous Healthcare Institution of the Tyumen region Medical Scientific Practical Center
  - Vladimir, Russia, 600020
    - SBHI of Vladimirskaya region City Hospital 4 of Vladimir
  - Volgograd, Russia, 400001
    - Family Medicine Clinic
  - Yekaterinburg, Russia, 620026
    - Central City Clinical Hospital 1 of the Oktyabrsky District
  - Yekaterinburg, Russia, 620102
    - State Budget Medical Institution Sverdlovsk Regional Clinical Hospital N1
Slovakia
- - Bardejov, Slovakia, 085 01
    - Alian, sro
  - Bratislava, Slovakia, 831 03
    - MediTask, sro
  - Bratislava, Slovakia, 833 48
    - Narodny ustav srdcovych a cievnych chorob, as
  - Bratislava, Slovakia, 851 01
    - Veria, sro
  - Brezno, Slovakia, 977 01
    - Nemocnica s poliklinikou Brezno, no
  - Košice, Slovakia, 040 01
    - Medical group Kosice sro
  - Košice, Slovakia, 040 22
    - Cardio D and R, sro Kosice
  - Lučenec, Slovakia, 984 01
    - Kardio 1 sro
  - Moldava nad Bodvou, Slovakia, 045 01
    - Medi M and M sro
  - Nitra, Slovakia, 949 01
    - Kardiocentrum Nitra sro
  - Nové Zámky, Slovakia, 940 01
    - Kardiomed NZ, sro
  - Námestovo, Slovakia, 029 01
    - Oralek, sro
  - Prešov, Slovakia, 080 01
    - Medikard, sro
  - Prešov, Slovakia, 080 01
    - Medispol, sro
  - Rožňava, Slovakia, 048 01
    - DIAB sro
  - Snina, Slovakia, 069 01
    - Mediluk sro
  - Svidník, Slovakia, 089 01
    - Interna SK, sro
  - Trebišov, Slovakia, 075 01
    - Areteus sro
  - Trenčín, Slovakia, 911 01
    - CardiOr, sro
South Korea
- - Busan, South Korea, 49201
    - Dong-A University Hospital
  - Busan, South Korea, 47392
    - Inje University Busan Paik Hospital
  - Cheongju-si, Chungcheongbuk-do, South Korea, 28644
    - Chungbuk National University Hospital
  - Daegu, South Korea, 42415
    - Yeungnam University Medical Center
  - Daegu, South Korea, 42601
    - Keimyung University, Dongsan hospital
  - Gwangju, South Korea, 501-757
    - Chonnam National University Hospital
  - Incheon, South Korea, 21565
    - Gachon University Gil Medical Center
  - Seongnam-si, Gyeonggi-do, South Korea, 13620
    - Seoul National University Bundang Hospital
  - Seoul, South Korea, 03080
    - Seoul National University Hospital
  - Seoul, South Korea, 05505
    - Asan Medical Center
  - Seoul, South Korea, 06351
    - Samsung Medical Center
  - Seoul, South Korea, 03181
    - Kangbuk Samsung Hospital
  - Seoul, South Korea, 03722
    - Severance Hospital, Yonsei University Health System
  - Seoul, South Korea, 06591
    - The Catholic University of Korea Seoul St Marys Hospital
  - Seoul, South Korea, 02841
    - Korea University Anam Hospital
  - Seoul, South Korea, 02447
    - Kyung Hee University Hospital
  - Seoul, South Korea, 135-700
    - Gangnam Severance Hospital
  - Suwon-si, Gyeonggi-do, South Korea, 16499
    - Ajou University Hospital
  - Wonju-si, Gangwon-do, South Korea, 26426
    - Yonsei University Wonju Severance Christian Hospital
Spain
- - Madrid, Spain, 28040
    - Fundacion Jimenez Diaz
  - Madrid, Spain, 28040
    - Hospital Clinico San Carlos
  - Madrid, Spain, 28041
    - Hospital Universitario 12 de Octubre
  - Madrid, Spain, 28046
    - Hospital Universitario La Paz
  - Madrid, Spain, 28006
    - Hospital Universitario de La Princesa
  - Madrid, Spain, 28702
    - Hospital Universitario Infanta Sofía
- Andalusia
  - Almería, Andalusia, Spain, 04120
    - Hospital Virgen del Mar
  - Córdoba, Andalusia, Spain, 14004
    - Hospital Universitario Reina Sofia
  - Granada, Andalusia, Spain, 18012
    - Hospital Universitario Virgen de las Nieves
  - Málaga, Andalusia, Spain, 29010
    - Hospital Clinico Universitario Virgen de la Victoria
  - Seville, Andalusia, Spain, 41009
    - Hospital Universitario Virgen Macarena
- Aragon
  - Zaragoza, Aragon, Spain, 50009
    - Hospital Universitario Miguel Servet
- Canary Islands
  - Las Palmas de Gran Canarias, Canary Islands, Spain, 35010
    - Hospital Universitario de Gran Canaria Doctor Negrin
- Castille and León
  - Valladolid, Castille and León, Spain, 47005
    - Hospital Clinico Universitario de Valladolid
- Catalonia
  - Badalona, Catalonia, Spain, 08916
    - Hospital Universitari Germans Trias i Pujol
  - Barcelona, Catalonia, Spain, 08036
    - Hospital Clinic i Provincial de Barcelona
  - Barcelona, Catalonia, Spain, 08025
    - Equip Atencio Primaria Sardenya
  - Reus, Catalonia, Spain, 43204
    - Hospital Universitari Sant Joan de Reus
- Galicia
  - A Coruña, Galicia, Spain, 15006
    - Complexo Hospitalario Universitario A Coruña
  - Santiago de Compostela, Galicia, Spain, 15706
    - Hospital Clinico Universitario de Santiago
  - Vigo, Galicia, Spain, 36312
    - Hospital Álvaro Cunqueiro
- Murcia
  - El Palmar, Murcia, Spain, 30120
    - Hospital Universitario Virgen de La Arrixaca
- Navarre
  - Pamplona, Navarre, Spain, 31008
    - Complejo Hospitalario de Navarra
- Valencia
  - Valencia, Valencia, Spain, 46010
    - Hospital Clinico Universitario de Valencia
  - Valencia, Valencia, Spain, 26026
    - Hospital Universitari i Politècnic La Fe
Sweden
- - Borås, Sweden, 501 82
    - Södra Älvsborgs Sjukhus
  - Falun, Sweden, 791 82
    - Falu Lasarett
  - Gothenburg, Sweden, 405 45
    - Carlanderska
  - Gothenburg, Sweden, 413 45
    - Sahlgrenska Universitetssjukhus
  - Helsingborg, Sweden, 252 20
    - PharmaSite Helsingborg
  - Härnösand, Sweden, 871 31
    - Obackakliniken i Harnosand
  - Jönköping, Sweden, 551 85
    - Länssjukhuset Ryhov
  - Karlstad, Sweden, 651 85
    - Centralsjukhuset Karlstad
  - Lidköping, Sweden, 531 85
    - Skaraborgs sjukhus Lidkoping
  - Lund, Sweden, 222 21
    - Clemenstorgets Hjartmottagning
  - Malmo, Sweden, 211 52
    - Pharmasite Malmo
  - Stockholm, Sweden, 117 27
    - Akardo MedSite
  - Umeå, Sweden, 901 85
    - Norrlands universitetssjukhus
  - Varberg, Sweden, 432 81
    - Hallands sjukhus Varberg
  - Östersund, Sweden, 831 83
    - Östersunds Sjukhus
Taiwan
- - Kaohsiung City, Taiwan, 83301
    - Kaohsiung Chang Gung Memorial Hospital
  - Kaohsiung City, Taiwan, 80756
    - Kaohsiung Medical University Chung-Ho Memorial Hospital
  - New Taipei City, Taiwan, 25160
    - Mackay Memorial Hospital Tamsui Branch
  - Taichung, Taiwan, 40705
    - Taichung Veterans General Hospital
  - Taichung, Taiwan, 40201
    - Chung Shan Medical University Hospital
  - Tainan, Taiwan, 70403
    - National Cheng Kung University Hospital
  - Taipei, Taiwan, 10002
    - National Taiwan University Hospital
  - Taipei, Taiwan, 11217
    - Taipei Veterans General Hospital
  - Taoyuan District, Taiwan, 33305
    - Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation
- Hualien
  - Hualien City, Hualien, Taiwan, 97002
    - Hualien Tzu Chi Hospital
Ukraine
- - Ivano-Frankivsk, Ukraine, 76018
    - Ivano-Frankivsk Regional Clinical Cardiology Center of Ivano-Frankivsk Regional Council
  - Kharkiv, Ukraine, 61002
    - Communal Healthcare Institution Kharkiv City Clinical Hospital No27
  - Kharkiv, Ukraine, 61106
    - Medical and Sanitary Unit of Open Joint Stock Company Kharkiv Tractor Plant
  - Kharkiv, Ukraine, 61176
    - Communal Noncommercial enterprise "City Hospital #8" of Kharkiv City Council
  - Kyiv, Ukraine, 01023
    - Oleksandrivska Clinical Hospital of Kyiv
  - Kyiv, Ukraine, 02091
    - Kyiv City Clinical Hospital 1
  - Kyiv, Ukraine, 02232
    - Communal Noncommercial Institution Consultative and Diagnostic Center of Desnianskyi District of Kyi
  - Kyiv, Ukraine, 02660
    - Kyiv City Clinical Emergency Medical Care Hospital
  - Kyiv, Ukraine, 03151
    - National Scientific Center "M.D. Strazhesko Institute of Cardiology"
  - Kyiv, Ukraine, 03680
    - State Institution National Scientific Center Acad MD Strazhesko Institute of cardiology of NAMS Ukr
  - Kyiv, Ukraine, 03680
    - State Institution National Scientific Center Acad Strazhesko Institute of Cardiology
  - Kyiv, Ukraine, 04050
    - Medical Centre CONSILIUM Medical
  - Uzhhorod, Ukraine, 88014
    - Zakarpattia Oblast Clinical Center of Cardiology and Cardio Surgery
  - Vinnytsia, Ukraine, 21018
    - Vinnytsia M I Pyrogov Regional Clinical Hospital Vinnytsia M I Pyrogov National Medical University
  - Vinnytsia, Ukraine, 21001
    - Private Small Enterprise, Medical Center Pulse
  - Zaporizhzhia, Ukraine, 69035
    - Communal Non-commercial enterprise "City Hospital #6 "of Zaporizhzhia City Council
United Kingdom
- - Aberdeen, United Kingdom, AB25 2ZN
    - Aberdeen Royal Infirmary
  - Barnsley, United Kingdom, S75 2EP
    - Barnsley Hospital
  - Bath, United Kingdom, BA1 3NG
    - Royal United Hospital
  - Belfast, United Kingdom, BT16 1RH
    - Ulster Hospital
  - Belfast, United Kingdom, BT12 6BA
    - Royal Victoria Hospital
  - Belfast, United Kingdom, BT7 2EB
    - Ormeau Health Centre
  - Bollington, United Kingdom, SK10 5JH
    - Bollington Medical Centre
  - Bournemouth, United Kingdom, BH7 7DW
    - Royal Bournemouth Hospital
  - Bristol, United Kingdom, BS37 4AX
    - West Walk Surgery
  - Burton-on-Trent, United Kingdom, DE13 0RB
    - University Hospitals of Derby and Burton NHS Foundation Trust
  - Chesterfield, United Kingdom, S40 4AA
    - Ashgate Medical Practice
  - Cleveleys, United Kingdom, FY5 3LF
    - Cleveleys Group Practice
  - Corby, United Kingdom, NN17 2UR
    - Lakeside Healthcare
  - Corby, United Kingdom, NN18 9EZ
    - Medinova Northamptonshire Dedicated Research Site
  - Coventry, United Kingdom, CV3 4FJ
    - MeDiNova Warwickshire Quality Research Site
  - Crawley, United Kingdom, RH10 7DX
    - Pound Hill Medical Group
  - Dundee, United Kingdom, DD1 9SY
    - Ninewells Hospital
  - Glasgow, United Kingdom, G31 2ER
    - Glasgow Royal Infirmary
  - Hull, United Kingdom, HU3 2RW
    - Hull Royal Infirmary
  - Inverness, United Kingdom, IV2 3JH
    - Highlands Clinical Research Facility, Raigmore Hospital
  - Liverpool, United Kingdom, L7 8XP
    - Royal Liverpool University Hospital
  - London, United Kingdom, NW3 2QG
    - Royal Free London NHS Foundation Trust
  - London, United Kingdom, SE1 9RT
    - Guys Hospital
  - London, United Kingdom, EC1M 6BQ
    - Barts Health NHS Trust
  - Manchester, United Kingdom, M23 9LT
    - Wythenshawe Hospital
  - Northwood, United Kingdom, HA6 2RN
    - Medinova North London Dedicated Research Centre
  - Nottingham, United Kingdom, NG5 1PB
    - Nottingham City Hospital
  - Nuneaton, United Kingdom, CV10 7DJ
    - George Eliot Hospital
  - Orpington, United Kingdom, BR5 3QG
    - Medinova South London Dedicated Research Centre
  - Penzance, United Kingdom, TR19 7HX
    - Mounts Bay Medical Hub
  - Peterborough, United Kingdom, PE7 1AT
    - The Health Centre Yaxley
  - Poole, United Kingdom, BH16 5PW
    - The Adam Practice
  - Romford, United Kingdom, RM1 3PJ
    - Medinova East London Dedicated Research Centre
  - Royal Leamington Spa, United Kingdom, CV32 4RA
    - Sherbourne Medical Centre
  - Saint Neots, United Kingdom, PE19 8BB
    - Eaton Socon Health Centre
  - Sandbach, United Kingdom, CW11 1EQ
    - Ashfield Primary Care Centre
  - Scunthorpe, United Kingdom, DN15 7BH
    - Scunthorpe General Hospital
  - Shipley, United Kingdom, BD18 3SA
    - Medinova Limited
  - Stamford, United Kingdom, PE9 2DH
    - Lakeside Healthcare Stamford
  - Stevenage, United Kingdom, SG1 4AB
    - Lister Hospital
  - Swansea, United Kingdom, SA2 8PP
    - Singleton Hospital
  - Thetford, United Kingdom, IP24 1JD
    - The Breckland Alliance
  - Torquay, United Kingdom, TQ2 7AA
    - Torbay Hospital
  - Wakefield, United Kingdom, WF1 4DG
    - Pinderfields Hospital
  - Watford, United Kingdom, WD25 7NL
    - Sheepcot Medical Practice
  - West Bromwich, United Kingdom, B71 4HJ
    - Sandwell General Hospital
  - Whitby, United Kingdom, YO21 1SD
    - Whitby Group Practice
  - Wokingham, United Kingdom, RG40 1XS
    - MeDiNova West London Quality Research Site
  - Worcester, United Kingdom, WR5 1DD
    - Worcestershire Royal Hospital
  - Yeovil, United Kingdom, BA21 4AT
    - Yeovil District Hospital
United States
- Alabama
  - Athens, Alabama, United States, 35611
    - North Alabama Research Center LLC
  - Birmingham, Alabama, United States, 35243
    - Cardiovascular Associates
  - Huntsville, Alabama, United States, 35801
    - Heart Center Research Llc
  - Mobile, Alabama, United States, 36608
    - Mobile Heart Specialists PC
- Arkansas
  - Little Rock, Arkansas, United States, 72205
    - Central Arkansas Veterans Healthcare System
  - Little Rock, Arkansas, United States, 72205
    - Arkansas Cardiology
- California
  - Beverly Hills, California, United States, 90211
    - Westside Medical Associates of Los Angeles
  - Beverly Hills, California, United States, 90210
    - Cardiovascular Research Foundation of Southern California
  - Dublin, California, United States, 94568
    - West Coast Research LLC
  - Palm Springs, California, United States, 92262
    - Desert Oasis Healthcare Medical Group
  - Riverside, California, United States, 92506
    - Covigilant Research, LLC
  - Roseville, California, United States, 95661
    - Sierra Clinical Research
  - Sacramento, California, United States, 95823
    - Center for Clinical Trials of Sacramento Inc
  - Torrance, California, United States, 90502
    - Harbor University of California Los Angeles Medical Center
- Colorado
  - Colorado Springs, Colorado, United States, 80906
    - Optumcare Colorado Springs LLC
  - Colorado Springs, Colorado, United States, 80909
    - University of Colorado Memorial Health System
  - Golden, Colorado, United States, 80401
    - New West Physicians
  - Littleton, Colorado, United States, 80120
    - South Denver Cardiology Associates
- Connecticut
  - Stamford, Connecticut, United States, 06905
    - Cardiology Associates of Fairfield County, PC
- Florida
  - Boca Raton, Florida, United States, 33434
    - Excel Medical Clinical Trials
  - Brandon, Florida, United States, 33511
    - Bay Area Cardiology
  - Crystal River, Florida, United States, 34429
    - Nature Coast Clinical Research LLC
  - Daytona Beach, Florida, United States, 32114
    - Daytona Heart Group
  - Daytona Beach, Florida, United States, 32117
    - Cardiology Research Associates
  - DeLand, Florida, United States, 32720
    - Complete Health Research
  - Delray Beach, Florida, United States, 33446
    - Cohen Medical Associates PA
  - Fort Lauderdale, Florida, United States, 33312
    - Jellinger and Lerman MD PA dba The Center for Diabetes and Endocrine Care
  - Green Cove Springs, Florida, United States, 32043
    - George E Platt MD
  - Hollywood, Florida, United States, 33021
    - Research Physicians Network Alliance
  - Jacksonville, Florida, United States, 32216
    - Jacksonville Center for Clinical Research
  - Jacksonville, Florida, United States, 32209
    - University of Florida and Shands Hospital
  - Jacksonville, Florida, United States, 32256
    - First Coast Cardiovascular Institute PA
  - Jacksonville Beach, Florida, United States, 32250
    - Baptist Health Research Institute
  - Miami, Florida, United States, 33173
    - Cardiovascular Research Center of South Florida
  - Miami, Florida, United States, 33155
    - Gad Research Center
  - Ocala, Florida, United States, 34471
    - Ocala Research Institute, Inc
  - Pensacola, Florida, United States, 32501
    - Cardiology Consultants
  - Port Charlotte, Florida, United States, 33952
    - Charlotte Heart Group Research Center
  - Sarasota, Florida, United States, 34239
    - Cardiovascular Center Of Sarasota
  - Sarasota, Florida, United States, 34232
    - Intercoastal Medical Group
  - Winter Park, Florida, United States, 32792
    - Florida Cardiology Group
  - Winter Park, Florida, United States, 32792
    - The Florida Lipid Institute
- Georgia
  - Johns Creek, Georgia, United States, 30024
    - Nsc Research
- Idaho
  - Coeur d'Alene, Idaho, United States, 83814
    - Kootenai Heart Clinics, LLC
- Illinois
  - Arlington Heights, Illinois, United States, 60005
    - Northwest Heart Clinical Research LLC
- Indiana
  - Evansville, Indiana, United States, 47713
    - Deaconess Clinic
  - Michigan City, Indiana, United States, 46360
    - LaPorte County Institute for Clinical Research
- Iowa
  - Davenport, Iowa, United States, 52801
    - Midwest Cardiovascular Research Foundation
  - Iowa City, Iowa, United States, 52242
    - The University of Iowa College of Public Health
  - West Des Moines, Iowa, United States, 50266
    - MercyOne Iowa Heart Center
- Kansas
  - Kansas City, Kansas, United States, 66160-7601
    - The University of Kansas Medical Center
- Kentucky
  - Covington, Kentucky, United States, 41011
    - Saint Elizabeth Covington
  - Lexington, Kentucky, United States, 40503
    - The Research Group of Lexington LLC
- Louisiana
  - Alexandria, Louisiana, United States, 71301
    - Alexandria Cardiology Clinic
  - Bossier City, Louisiana, United States, 71111
    - Grace Research Llc
  - Eunice, Louisiana, United States, 70535
    - Horizon Research Group of Opelousas LLC
  - Hammond, Louisiana, United States, 70403
    - Louisiana Heart Center
  - Natchitoches, Louisiana, United States, 71457
    - Barnum Medical Research
  - Shreveport, Louisiana, United States, 71105
    - Grace Research Llc
  - Slidell, Louisiana, United States, 70458
    - Louisiana Heart Center
- Maine
  - Bangor, Maine, United States, 04401
    - Northern Light Eastern Maine Medical Center
  - Biddeford, Maine, United States, 04005
    - Southern Maine Health Care
- Maryland
  - Baltimore, Maryland, United States, 21229
    - Maryland Cardiovascular Specialists
  - Beltsville, Maryland, United States, 20705
    - Metropolitan Cardiovascular Consultants Llc
  - Salisbury, Maryland, United States, 21804
    - TidalHealth Peninsula Regional, Inc
- Massachusetts
  - Boston, Massachusetts, United States, 02215
    - Brigham and Womens Hospital
  - Framingham, Massachusetts, United States, 01701
    - Charles River Medical Associates
  - Great Barrington, Massachusetts, United States, 01230
    - East Mountain Medical Associates, PC
  - Springfield, Massachusetts, United States, 01199
    - Baystate Health Center
- Michigan
  - Flint, Michigan, United States, 48504
    - Ahmed Arif Medical Research Center LLC
  - Grand Rapids, Michigan, United States, 49546
    - Healthy Heart Cardiology
  - Jackson, Michigan, United States, 49201
    - Rajendra H Mehta, MD, PC
  - Traverse City, Michigan, United States, 49684
    - Munson Medical Center
- Minnesota
  - Duluth, Minnesota, United States, 55805
    - Saint Marys Medical Center
  - Minneapolis, Minnesota, United States, 55407
    - Minneapolis Heart Institute Foundation
  - Saint Cloud, Minnesota, United States, 56303
    - Saint Cloud Hospital
  - Saint Paul, Minnesota, United States, 55102
    - HealthEast Medical Research Institute
- Missouri
  - Kansas City, Missouri, United States, 64128
    - Kansas City Veterans Affairs Medical Center
  - St Louis, Missouri, United States, 63141
    - Mercy Research
- Montana
  - Great Falls, Montana, United States, 59405
    - Great Falls Clinic LLP
- Nebraska
  - Lincoln, Nebraska, United States, 68506
    - Bryan Heart
  - Omaha, Nebraska, United States, 68105
    - Nebraska Western Iowa Health Care System
- Nevada
  - Las Vegas, Nevada, United States, 89128
    - Palm Research Center Inc
- New Jersey
  - Voorhees Township, New Jersey, United States, 08043
    - Virtua Health, Inc.
- New York
  - Brooklyn, New York, United States, 11206
    - Healthwise Medical Associates
  - Cheektowaga, New York, United States, 14227
    - Trinity Medical Western New York, PC
  - Kingston, New York, United States, 12401
    - WMCHealth Heart and Vascular Institute Kingston Division of Cardiology
  - Manhasset, New York, United States, 11030
    - Northwell Health Physician Partners Cardiology
  - New Hyde Park, New York, United States, 11042
    - North Shore Diabetes and Endocrine Associates
  - New York, New York, United States, 10022
    - Northwell Health Lenox Hill Heart and Vascular
  - Poughkeepsie, New York, United States, 12601
    - Hudson Valley Cardiovascular Physicians PC
  - Saratoga Springs, New York, United States, 12866
    - Saratoga Clinical Research, LLC
  - Southampton, New York, United States, 11968
    - Division of Cardiovascular Research at Peconic Bay Medical Center
- North Carolina
  - Asheville, North Carolina, United States, 28803
    - Asheville Cardiology Associates
  - Chapel Hill, North Carolina, United States, 27599
    - University of North Carolina at Chapel Hill
  - Charlotte, North Carolina, United States, 28204
    - Novant Health Heart and Vascular Institute
  - Greensboro, North Carolina, United States, 27401
    - Moses H Cone Memorial Hospital
  - Mooresville, North Carolina, United States, 28117
    - Crossroads Clinical Research Inc
  - Rocky Mount, North Carolina, United States, 27804
    - Piedmont Medical Group Research of Rocky Mount
  - Salisbury, North Carolina, United States, 28144
    - PMG Research of Salisbury
  - Winston-Salem, North Carolina, United States, 27157
    - Wake Forest University Health Sciences
  - Winston-Salem, North Carolina, United States, 27103
    - Novant Health Forsyth Medical Center
- North Dakota
  - Fargo, North Dakota, United States, 58104
    - Lillestol Research LLC
- Ohio
  - Cincinnati, Ohio, United States, 45219
    - The Christ Hospital
  - Cleveland, Ohio, United States, 44106
    - University Hospitals Cleveland Medical Center
  - Elyria, Ohio, United States, 44035
    - North Ohio Heart Center
  - Marion, Ohio, United States, 43302
    - Sanjay Vora Research LLC
  - Sandusky, Ohio, United States, 44870
    - North Ohio Heart Center-Sandusky
  - Springfield, Ohio, United States, 45504
    - Heart House Research Foundation
- Oklahoma
  - Norman, Oklahoma, United States, 73069
    - Intend Research
  - Tulsa, Oklahoma, United States, 74133
    - Oklahoma Heart Institute
- Oregon
  - Portland, Oregon, United States, 97239
    - Oregon Health and Science University
- Pennsylvania
  - Camp Hill, Pennsylvania, United States, 17011
    - Capital Area Research LLC
  - Camp Hill, Pennsylvania, United States, 17011
    - Geisinger Holy Spirit
  - Doylestown, Pennsylvania, United States, 18901
    - Doylestown Health Cardiology
  - Jersey Shore, Pennsylvania, United States, 17740
    - Lycoming Internal Medicine Inc
  - Philadelphia, Pennsylvania, United States, 19104
    - Perelman Center for Advanced Medicine
  - Philadelphia, Pennsylvania, United States, 19107
    - Cardiology Consultants of Philadelphia CCP
  - Pittsburgh, Pennsylvania, United States, 15213
    - University of Pittsburgh Medical Center
- Rhode Island
  - Providence, Rhode Island, United States, 02906
    - Miriam Hospital
- South Carolina
  - Charleston, South Carolina, United States, 29412
    - Pharmacorp Clinical Trials Inc
  - Fort Mill, South Carolina, United States, 29707
    - Piedmont Research Partners
  - Greenville, South Carolina, United States, 29607
    - Tribe Clinical Research LLC DBA Mountain View Clinical Research
  - Little River, South Carolina, United States, 29566
    - Main Street Physicians Care Waterway
  - Murrells Inlet, South Carolina, United States, 29576
    - The Diabetes Center
  - Summerville, South Carolina, United States, 29485
    - Palmetto Clinical Research
- South Dakota
  - Rapid City, South Dakota, United States, 57701
    - Monument Health Clinical Research
- Tennessee
  - Oak Ridge, Tennessee, United States, 37830
    - Parkway Cardiology Associates
- Texas
  - Dallas, Texas, United States, 75235
    - Southwest Family Medicine Associates
  - Dallas, Texas, United States, 75226
    - Soltero Cardiovascular Research Center
  - Kingwood, Texas, United States, 77339
    - Texas Cardiology Associates of Houston
  - Kingwood, Texas, United States, 77339
    - Humble Cardiology Associates
  - Lufkin, Texas, United States, 75904
    - Texas Institute for Kidney and Endocrine Disorders
  - McKinney, Texas, United States, 75071
    - Texas Institute Of Cardiology
  - Mesquite, Texas, United States, 75149
    - Southern Endocrinology Associates PA
  - Odessa, Texas, United States, 79761
    - Permian Research Foundation
  - San Antonio, Texas, United States, 78201
    - South Texas Cardiovascular Consultants PLLC
  - San Antonio, Texas, United States, 78229
    - Mercury Medical Conversions LTD
  - Tomball, Texas, United States, 77375
    - Northwest Houston Heart Center
- Utah
  - Farmington, Utah, United States, 84025
    - Alpine Research Organization
- Virginia
  - Suffolk, Virginia, United States, 23435
    - Suffolk Multispecialty Research LLC
  - Winchester, Virginia, United States, 22601
    - Selma Medical Associates
- Washington
  - Puyallup, Washington, United States, 98372
    - MultiCare Institute for Research and Innovation
  - Tacoma, Washington, United States, 98405
    - Universal Research Group LLC
- Wisconsin
  - Wausau, Wisconsin, United States, 54401
    - Aspirus Research Institute

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

46 years to 75 years (Adult, Older Adult)

Accepts Healthy Volunteers

Description

Inclusion criteria:

Age: Adult participants ≥ 50 (men) or ≥ 55 (women) to ˂ 80 years of age (either sex) and meeting lipid criteria.
Lipid Criteria: Low-density lipoprotein cholesterol (LDL-C) ≥ 90 mg/dL (≥ 2.3 mmol/L) or non high-density lipoprotein cholesterol (non-HDL)-C ≥ 120 mg/dL (≥ 3.1 mmol/L), or apolipoprotein B ≥ 80 mg/dL (≥ 1.56 µmol/L).
3.Diagnostic evidence of at least one of the following (A-D) at screening:

A.Significant coronary artery disease (CAD) meeting at least 1 of the following criteria:

History of coronary revascularization with multi-vessel coronary disease as evidenced by any of the following:
1. percutaneous coronary intervention (PCI) of 2 or more vessels, including branch arteries,
2. PCI or coronary artery bypass grafting (CABG) with residual 50% stenosis in a separate, unrevascularized vessel, or
3. multi-vessel CABG 5 years or more prior to screening.
Significant coronary disease without prior revascularization as evidenced by either a ≥70% stenosis of at least 1 coronary artery, ≥50% stenosis of 2 or more coronary arteries, or ≥50% stenosis of the left main coronary artery.
known coronary artery calcium score ≥100 in participants without a coronary artery revascularization prior to randomization.

B. Significant atherosclerotic cerebrovascular disease meeting at least 1 of the following criteria:

prior transient ischemic attack with ≥50% carotid stenosis.
internal or external carotid artery stenosis of ≥70% or 2 or more ≥50% stenoses.
prior internal or external carotid artery revascularization.

C. Significant peripheral arterial disease meeting at least 1 of the following criteria:

≥50% stenosis in a limb artery.
history of abdominal aorta treatment (percutaneous and surgical) due to atherosclerotic disease.
ankle brachial index (ABI) <0.85.

D. Diabetes mellitus with at least 1 of the following:

known microvascular disease, defined by diabetic nephropathy or treated retinopathy. Diabetic nephropathy defined as persistent microalbuminuria (urinary albumin to creatinine ratio ≥30mg/g) and/or persistent estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m^2 that is not reversible due to an acute illness.
chronic daily treatment with an intermediate or long-acting insulin.
diabetes diagnosis ≥10 years ago.
•At least 1 of the following 1 high-risk criteria (most recent lab values within 6 months prior to screening, as applicable):
Polyvascular disease, defined as coronary, carotid, or peripheral artery stenosis ≥50% in a second distinct vascular location in a participant with coronary, cerebral or peripheral arterial disease (A, B, or C above).
Presence of either diabetes mellitus or metabolic syndrome in a participant with coronary, cerebral, or peripheral artery disease (A, B, or C above).
At least 1 coronary, carotid, or peripheral artery residual stenosis of ≥50% in a participant with diabetes meeting inclusion criterion (D above).
LDL-C ≥130 mg/dL (≥3.36 mmol/L), OR non-HDL-C ≥160 mg/dL (≥4.14 mmol/L), OR apolipoprotein B ≥120 mg/dL (2.3 µmol/L) if available.
Lipoprotein (a) >125 nmol/L (50 mg/dL).
Known familial hypercholesterolemia.
Family history of premature coronary artery disease defined as an MI or CABG in the participant's father or brother at age <55 years or an MI or CABG in the participant's mother or sister at age <60 years.
High sensitive c-reactive protein (hsCRP) ≥3.0 mg/L in the absence of an acute illness.
Current tobacco use.
-≥65 years of age.
Menopause before 40 years of age.
eGFR 15 to <45 mL/min/1.73 m^2.
Coronary artery calcification score ≥300 in a participant without a coronary revascularization prior to randomization.

Exclusion criteria

MI or stroke prior to randomization.
CABG ˂ 3 months prior to screening.
eGFR ˂ 15 mL/min/1.73 m^2.
Uncontrolled or recurrent ventricular tachycardia in the absence of an implantable-cardioverter defibrillator.
Atrial fibrillation or atrial flutter not on anticoagulation therapy (vitamin K antagonist, heparin, low molecular weight heparin, fondaparinux,or non-Vitamin K antagonist oral anticoagulant).
Triglycerides ≥ 500 mg/dL (5.7 mmol/L) measured up to 3 months prior to screening. The most recent results must be used.
Last measured left-ventricular ejection fraction ˂ 30% or New York Heart Association (NYHA) Functional Class III/IV.
Planned arterial revascularization.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Quadruple

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: Placebo Participants will receive placebo subcutaneous injection once every 2 weeks (Q2W).	Drug: Placebo Administered subcutaneously using an autoinjector pen.
Experimental: Evolocumab 140 mg Q2W Participants will receive 140 mg evolocumab by subcutaneous injection Q2W.	Drug: Evolocumab Administered subcutaneously using an autoinjector pen. Other Names: Repatha AMG 145

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time to Coronary Heart Disease Death, Myocardial Infarction, or Ischemic Stroke Time Frame: From randomization; for approximately a median of 4.5 years	Time to coronary heart disease (CHD) death, myocardial infarction (MI), or ischemic stroke, whichever occurs first.	From randomization; for approximately a median of 4.5 years
Time to Coronary Heart Disease Death, Myocardial Infarction, Ischemic Stroke, or Any Ischemia-driven Arterial Stroke Time Frame: From randomization; for approximately a median of 4.5 years	Time to CHD death, MI, ischemic stroke, or any ischemia-driven arterial revascularization, whichever occurs first.	From randomization; for approximately a median of 4.5 years

Secondary Outcome Measures

Outcome Measure	Time Frame
Time to MI, Ischemic Stroke, or Any Ischemia-driven Arterial Revascularization Time Frame: From randomization; for approximately a median of 4.5 years	From randomization; for approximately a median of 4.5 years
Time to CHD Death, MI, or Any Ischemia-driven Arterial Revascularization Time Frame: From randomization; for approximately a median of 4.5 years	From randomization; for approximately a median of 4.5 years
Time to Cardiovascular Death, MI, or Ischemic Stroke Time Frame: From randomization; for approximately a median of 4.5 years	From randomization; for approximately a median of 4.5 years
Time to CHD Death or MI Time Frame: From randomization; for approximately a median of 4.5 years	From randomization; for approximately a median of 4.5 years
Time to Myocardial Infarction Time Frame: From randomization; for approximately a median of 4.5 years	From randomization; for approximately a median of 4.5 years
Time to Any Ischemia-driven Arterial Revascularization Time Frame: From randomization; for approximately a median of 4.5 years	From randomization; for approximately a median of 4.5 years
Time to CHD Death Time Frame: From randomization; for approximately a median of 4.5 years	From randomization; for approximately a median of 4.5 years
Time to Cardiovascular Death Time Frame: From randomization; for approximately a median of 4.5 years	From randomization; for approximately a median of 4.5 years
Time to All Cause of Death Time Frame: From randomization; for approximately a median of 4.5 years	From randomization; for approximately a median of 4.5 years
Time to Ischemic Stroke Time Frame: From randomization; for approximately a median of 4.5 years	From randomization; for approximately a median of 4.5 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Amgen

Investigators

Study Director: MD, Amgen

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

AmgenTrials clinical trials website

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

June 11, 2019

Primary Completion (Actual)

July 25, 2025

Study Completion (Actual)

July 25, 2025

Study Registration Dates

First Submitted

March 11, 2019

First Submitted That Met QC Criteria

March 11, 2019

First Posted (Actual)

March 13, 2019

Study Record Updates

Last Update Posted (Estimated)

November 10, 2025

Last Update Submitted That Met QC Criteria

November 7, 2025

Last Verified

November 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

20170625
2018-004565-14 (EudraCT Number)
2023-503673-38-00 (Ctis)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

De-identified individual patient data for variables necessary to address the specific research question in an approved data sharing request.

IPD Sharing Time Frame

Data sharing requests relating to this study will be considered beginning 18 months after the study has ended and either 1) The product and indication have been granted marketing authorization in both the US and Europe or 2) clinical development for the product and/or indication discontinues and the data will not be submitted to regulatory authorities. There is no end date for eligibility to submit a data sharing request for this study.

IPD Sharing Access Criteria

Qualified researchers may submit a request containing the research objectives, the Amgen product(s) and Amgen study/studies in scope, endpoints/outcomes of interest, statistical analysis plan, data requirements, publication plan, and qualifications of the researcher(s). In general, Amgen does not grant external requests for individual patient data for the purpose of re-evaluating safety and efficacy issues already addressed in the product labelling. Requests are reviewed by a committee of internal advisors. If not approved, a Data Sharing Independent Review Panel will arbitrate and make the final decision. Upon approval, information necessary to address the research question will be provided under the terms of a data sharing agreement. This may include anonymized individual patient data and/or available supporting documents, containing fragments of analysis code where provided in analysis specifications. Further details are available at the link below.

IPD Sharing Supporting Information Type

STUDY_PROTOCOL
SAP
ICF
CSR

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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Study Overview

Status

Conditions

Intervention / Treatment

Study Type

Enrollment (Actual)

Phase

Contacts and Locations

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Secondary Outcome Measures

Outcome Measure

Time Frame

Collaborators and Investigators

Sponsor

Investigators

Publications and helpful links

General Publications

Helpful Links

Study record dates

Study Major Dates

Study Start (Actual)

Primary Completion (Actual)

Study Completion (Actual)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Actual)

Study Record Updates

Last Update Posted (Estimated)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

IPD Plan Description

IPD Sharing Time Frame

IPD Sharing Access Criteria

IPD Sharing Supporting Information Type

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product

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