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Effetto di Evolocumab in pazienti ad alto rischio cardiovascolare senza precedente infarto miocardico o ictus (VESALIUS-CV)

1 giugno 2026 aggiornato da: Amgen

Uno studio multicentrico in doppio cieco, randomizzato, controllato con placebo per valutare l'impatto di Evolocumab sugli eventi cardiovascolari maggiori nei pazienti ad alto rischio cardiovascolare senza precedente infarto del miocardio o ictus

Questo studio valuterà l'effetto dell'abbassamento del colesterolo lipoproteico a bassa densità (LDL-C) con evolocumab sui principali eventi cardiovascolari negli adulti senza un precedente infarto del miocardio (MI) o ictus che sono ad alto rischio di un evento cardiovascolare.

Panoramica dello studio

Stato

Completato

Condizioni

Malattia coronarica (CHD)

Intervento / Trattamento

Tipo di studio

Interventistico

Iscrizione (Effettivo)

12301

Fase

Fase 3

Contatti e Sedi

Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.

Luoghi di studio

Argentina
- - Corrientes, Argentina, W3400AMZ
    - Instituto de Cardiologia de Corrientes Juana Francisca Cabral
  - Córdoba, Argentina, X5003DCE
    - Instituto Medico DAMIC - Fundacion Rusculleda
  - Salta, Argentina, A4400ANW
    - Cordis Sa
  - San Juan, Argentina, J5400ARW
    - Clinica El Castaño
  - San Luis, Argentina, D5702JRS
    - Instituto Cardiovascular San Luis
  - Santa Fe, Argentina, S3000FWO
    - Centro de Investigaciones Clinicas del Litoral
- Buenos Aires
  - Bahía Blanca, Buenos Aires, Argentina, B8000FTD
    - Instituto de Investigaciones Clínicas Bahia Blanca
  - CABA, Buenos Aires, Argentina, C1426ABP
    - Fundacion Respirar
  - CABA, Buenos Aires, Argentina, C1023AAB
    - STAT Research
  - CABA, Buenos Aires, Argentina, C1027AAP
    - CINME - Centro De Investigaciones Metabolicas
  - CABA, Buenos Aires, Argentina, C1119ACN
    - Ciprec - Centro de Investigacion y Prevencion Cardiovascular
  - CABA, Buenos Aires, Argentina, C1406BOA
    - Consultorio Medico Dr Litvak Bruno
  - CABA, Buenos Aires, Argentina, C1407GTN
    - Centro de Especialidades Medicas - Cemedic
  - CABA, Buenos Aires, Argentina, C1425AGC
    - Centro Medico Laura Maffei
  - CABA, Buenos Aires, Argentina, C1425BNG
    - Cardiología Palermo
  - CABA, Buenos Aires, Argentina, C1425DES
    - CEDIC - Centro de Investigacion Clinica
  - CABA, Buenos Aires, Argentina, C1426ABP
    - Centro Médico Dra de Salvo
  - Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1012AAR
    - Instituto de Investigaciones Metabólicas - IDIM
  - Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1093AAS
    - Hospital Universitario Fundacion Favaloro
  - Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1428ART
    - ICBA - Instituto Cardiovascular de Buenos Aires
  - Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1430CKE
    - Glenny Corp SA
  - Mar del Plata, Buenos Aires, Argentina, B7600FZN
    - Instituto de Investigaciones Clinicas Mar del Plata
  - Morón, Buenos Aires, Argentina, B1708EPE
    - Ciad - Consultorio Integral de Atencion al Diabetico
  - Ramos Mejía, Buenos Aires, Argentina, B1704ETD
    - DIM Clinica Privada
  - San Nicolás de los Arroyos, Buenos Aires, Argentina, B2900DMH
    - Instituto de Investigaciones Clinicas de San Nicolas
  - Zárate, Buenos Aires, Argentina, B2800DGH
    - Instituto de Investigaciones Clínicas Zárate
- Córdoba Province
  - Córdoba, Córdoba Province, Argentina, 5000
    - Clinica Privada del Prado
  - Villa María, Córdoba Province, Argentina, X5900JKA
    - Clinica Fusavim Privada SRL
- La Pampa Province
  - Santa Rosa, La Pampa Province, Argentina, 6300
    - Sanatorio Santa Rosa Srl
- Santa Fe Province
  - Rosario, Santa Fe Province, Argentina, 2000
    - Instituto de Investigaciones Clínicas Rosario-Sanatorio Delta
  - Rosario, Santa Fe Province, Argentina, 2000
    - Sanatorio Plaza
- Tucumán Province
  - San Miguel de Tucumán, Tucumán Province, Argentina, 4000
    - Centro Modelo de Cardiologia
  - San Miguel de Tucumán, Tucumán Province, Argentina, 4000
    - Clinical Mayo de Urgencias Medicas Cruz Blanca SRL
Australia
- - Woolloongabba, Australia, 4102
    - Dr Heart Pty Ltd
- Australian Capital Territory
  - Garran, Australian Capital Territory, Australia, 2605
    - Canberra Hospital
- New South Wales
  - Camperdown, New South Wales, Australia, 2050
    - Royal Prince Alfred Hospital
  - Liverpool, New South Wales, Australia, 2170
    - Liverpool Hospital
  - Maroubra, New South Wales, Australia, 2035
    - Australian Clinical Research Network
- Queensland
  - Auchenflower, Queensland, Australia, 4066
    - Heartcare Partners
  - Bundaberg, Queensland, Australia, 4670
    - Bundaberg Cardiology
  - Fortitude Valley, Queensland, Australia, 4006
    - Holdsworth House Medical Brisbane
  - Milton, Queensland, Australia, 4064
    - Core Research Group Pty Ltd
- South Australia
  - Adelaide, South Australia, Australia, 5000
    - Royal Adelaide Hospital
  - Adelaide, South Australia, Australia, 5000
    - Heart and Vascular Research
  - Ashford, South Australia, Australia, 5035
    - SA Heart
  - Leabrook, South Australia, Australia, 5068
    - Adelaide Cardiology Practice - Leabrook Clinic
- Tasmania
  - Hobart, Tasmania, Australia, 7000
    - Royal Hobart Hospital
- Victoria
  - Berwick, Victoria, Australia, 3806
    - HeartCare Victoria - Berwick
  - Clayton, Victoria, Australia, 3168
    - Monash Medical Centre
  - Epping, Victoria, Australia, 3076
    - The Cardiologists Proprietary Limited
  - Geelong, Victoria, Australia, 3220
    - Barwon Health Geelong Hospital
  - Ringwood, Victoria, Australia, 3134
    - GenesisCare Ringwood
- Western Australia
  - Bentley, Western Australia, Australia, 6102
    - Curtin University Centre of Clinical Research and Education
  - Joondalup, Western Australia, Australia, 5068
    - HeartCare Western Australia - Joondalup
  - Murdoch, Western Australia, Australia, 6150
    - Fiona Stanley Hospital
Austria
- - Feldkirch, Austria, 6800
    - Landeskrankenhaus Feldkirch
  - Graz, Austria, 8036
    - Medizinische Universitaet Graz
  - Innsbruck, Austria, 6020
    - Medizinische Universitaet Innsbruck
  - Klagenfurt, Austria, 9020
    - Klinikum Klagenfurt am Woerthersee
  - Linz, Austria, 4010
    - Ordensklinikum Linz Barmherzige Schwestern
  - Vienna, Austria, 1160
    - Klinik Ottakring
  - Vienna, Austria, 1030
    - Klinik Landstrasse
  - Vienna, Austria, 1090
    - Universitaetsklinikum Allgemeines Krankenhaus Wien
  - Vienna, Austria, 1130
    - Klinik Hietzing
  - Vienna, Austria, 1060
    - Zentrum fuer klinische Studien - Dr Hanusch GmbH
Belgio
- - Aalst, Belgio, 9300
    - Algemeen Stedelijk Ziekenhuis Aalst
  - Aalst, Belgio, 9300
    - Onze Lieve Vrouw Ziekenhuis - campus Aalst
  - Antwerp, Belgio, 2020
    - Ziekenhuis Netwerk Antwerpen Middelheim
  - Antwerp, Belgio, 2060
    - Ziekenhuis Netwerk Antwerpen Stuivenberg
  - Brussels, Belgio, 1200
    - Universite Catholique de Louvain Cliniques Universitaires Saint Luc
  - Dendermonde, Belgio, 9200
    - AZ Sint Blasius
  - Ghent, Belgio, 9000
    - Algemeen Ziekenhuis Sint Lucas
  - Gozée, Belgio, 6534
    - Medif sprl
  - Ham, Belgio, 3945
    - Dokter Mortelmans bvba
  - Hasselt, Belgio, 3500
    - Jessa Ziekenhuis - Campus Virga Jesse
  - Leuven, Belgio, 3000
    - Universitair Ziekenhuis Leuven - Campus Gasthuisberg
  - Linkebeek, Belgio, 1630
    - Medilink sprl
  - Mons, Belgio, 7000
    - Centre Hospitalier Universitair Ambroise Pare
  - Overpelt, Belgio, 3900
    - Maria Ziekenhuis Noord-Limburg
  - Tessenderlo, Belgio, 3980
    - Testumed vzw
Brasile
- - Rio de Janeiro, Brasile, 20241-180
    - IBPClin Instituto Brasil de Pesquisa Clinica
  - São Paulo, Brasile, 05403-000
    - Instituto do Coracao do Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo
- Ceará
  - Fortaleza, Ceará, Brasile, 60430-350
    - Centro de Pesquisas em Diabetes e Doencas Endocrino Metabolicas
- Federal District
  - Brasília, Federal District, Brasile, 71625-175
    - Centro de Pesquisa Clinica do Brasil
- Minas Gerais
  - Belo Horizonte, Minas Gerais, Brasile, 30150-240
    - Cardresearch Cardiologia Assistencial de Pesquisa
  - Belo Horizonte, Minas Gerais, Brasile, 31110-580
    - Fundação Hospitalar São Francisco de Assis
  - Uberlândia, Minas Gerais, Brasile, 38411-186
    - Eurolatino Pesquisas Medicas
- Paraná
  - Campina Grande do Sul, Paraná, Brasile, 83430-000
    - Sociedade Hospitalar Angelina Caron
  - Curitiba, Paraná, Brasile, 80045-170
    - Quanta Diagnosticos e Terapia
  - Curitiba, Paraná, Brasile, 80230-130
    - Puc Trials - Núcleo de Pesquisa Clínica da Escola de Medicina da Pucpr/Epicenter
  - Curitiba, Paraná, Brasile, 80730-150
    - Nucleo de Pesquisa Clinica
- Rio Grande do Sul
  - Porto Alegre, Rio Grande do Sul, Brasile, 90610-000
    - Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul
  - Porto Alegre, Rio Grande do Sul, Brasile, 91350-200
    - Hospital Nossa Senhora da Conceicao
  - Porto Alegre, Rio Grande do Sul, Brasile, 90035-903
    - Núcleo de Pesquisa em Cirurgia Vascular
- Santa Catarina
  - Blumenau, Santa Catarina, Brasile, 89020-430
    - AngioCor Blumenau
- São Paulo
  - Campinas, São Paulo, Brasile, 13060-080
    - Instituto de Pesquisa Clínica de Campinas
  - Campinas, São Paulo, Brasile, 13010-001
    - Centro Especializado em Cardiologia
  - Marília, São Paulo, Brasile, 17515-000
    - Instituto do Coracao de Marilia
  - São José do Rio Preto, São Paulo, Brasile, 15090-000
    - Fundação Faculdade Regional de Medicina de São José do Rio Preto
  - São Paulo, São Paulo, Brasile, 01228-200
    - Centro de Pesquisas Clinicas Cpclin
Bulgaria
- - Burgas, Bulgaria, 8000
    - Ambulatory for special outpatient medical aid in Cardiology-Private Practice Dr Elena Dotcheva EOOD
  - Haskovo, Bulgaria, 6300
    - Multiprofile Hospital for Active Treatment - Haskovo AD
  - Pernik, Bulgaria, 2300
    - Specialty Hospital for Active treatment in Cardiology Sveti Georgi - Pernik OOD
  - Pleven, Bulgaria, 5800
    - Medical Center Medconsult OOD
  - Pleven, Bulgaria, 5800
    - University Multiprofile Hospital for Active Treatment Dr Georgi Stranski EAD
  - Plovdiv, Bulgaria, 4001
    - University Multiprofile Hospital for Active Treatment Sveti Georgi EAD
  - Plovdiv, Bulgaria, 4003
    - Multiprofile Hospital for Active Treatment- Medical Complex- Sveti Ivan Rilski EOOD
  - Sofia, Bulgaria, 1527
    - University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna - ISUL EAD
  - Sofia, Bulgaria, 1233
    - National Multiprofile Transport Hospital Tzar Boris III
  - Sofia, Bulgaria, 1233
    - Fifth Multiprofile Hospital for Active Treatment - Sofia EAD
  - Sofia, Bulgaria, 1309
    - Medical Center for Specialized Medical Care of Cardiovascular Diseases OOD
  - Sofia, Bulgaria, 1407
    - Acibadem City Clinic Multiprofile Hospital for Active Treatment Tokuda EAD
  - Sofia, Bulgaria, 1407
    - Medical Center Excelsior OOD
  - Sofia, Bulgaria, 1606
    - University Multiprofile Hospital for Active Treatment and Emergency Medicine N I Pirogov EAD
  - Sofia, Bulgaria, 1680
    - Diagnostic-Consultative Center Convex EOOD
  - Sofia, Bulgaria, 1680
    - Medical center Kalimat EOOD
  - Sofia, Bulgaria, 1750
    - Multiprofile Hospital for Active Treatment Sveta Anna Sofia AD
  - Stara Zagora, Bulgaria, 6000
    - Medical Center Orpheus OOD
  - Veliko Tarnovo, Bulgaria, 5002
    - Multiprofile Regional Hospital for Active Treatment Dr Stefan Cherkezov AD
Canada
- Alberta
  - Calgary, Alberta, Canada, T2H 2G4
    - LMC Clinical Research Incorporated
- British Columbia
  - Surrey, British Columbia, Canada, V3V 0C6
    - SMH Cardiology Clinical Trials Incorporated
  - Vancouver, British Columbia, Canada, V5Y 3W2
    - Dr T G Elliott Incorporated - BC Diabetes
- Manitoba
  - Winnipeg, Manitoba, Canada, R3C 0N2
    - Winnipeg Clinic
- New Brunswick
  - Moncton, New Brunswick, Canada, E1G 1A7
    - G A Research Associates Limited
- Newfoundland and Labrador
  - Mount Pearl, Newfoundland and Labrador, Canada, A1N 1W7
    - Commonwealth Medical Clinic
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 3A7
    - Queen Elizabeth II Health Sciences Centre, Halifax Infirmary
- Ontario
  - Ajax, Ontario, Canada, L1Z 0B1
    - Heart Health Institute
  - Barrie, Ontario, Canada, L4N 7L3
    - LMC Clinical Research Incorporated
  - Brampton, Ontario, Canada, L6S 0C6
    - LMC Clinical Research Incorporated
  - Brampton, Ontario, Canada, L6Z 4N5
    - Brampton Clinical Trials
  - Concord, Ontario, Canada, L4K 4M2
    - LMC Clinical Research Incorporated Thornhill
  - Etobicoke, Ontario, Canada, M9R 4E1
    - LMC Clinical Research Incorporated
  - Hamilton, Ontario, Canada, L8L 2X2
    - Hamilton Health Sciences Hamilton General Hospital
  - London, Ontario, Canada, N6G 2M1
    - Western Centre for Public Health and Family Medicine - Western University
  - Markham, Ontario, Canada, L3P 7P2
    - My Endo Diabetes and Endocrinology Center
  - Nepean, Ontario, Canada, K2J 0V2
    - LMC Clinical Research Incorporated
  - Newmarket, Ontario, Canada, L3Y 5G8
    - SKDS Research Incorporated
  - Newmarket, Ontario, Canada, L3Y 2P6
    - Partners in Advanced Cardiac Evaluation
  - Oakville, Ontario, Canada, L6K 3W7
    - Oakville Cardiovascular Research
  - Oshawa, Ontario, Canada, L1J 2K1
    - Dr James Cha
  - Peterborough, Ontario, Canada, K9J 0B2
    - Kawartha Cardiology Clinical Trials
  - Sarnia, Ontario, Canada, N7T 4X3
    - Bluewater Clinical Research Group Incorporated
  - Scarborough Village, Ontario, Canada, M1B 4Z8
    - Heart Health Institute Research Incorporated
  - Scarborough Village, Ontario, Canada, M1B 5N1
    - Corcare Cardiovascular Research
  - Toronto, Ontario, Canada, M5S 1B2
    - Womens College Hospital
  - Toronto, Ontario, Canada, M6B 3H7
    - North York Diagnostic and Cardiac Centre
  - Weston, Ontario, Canada, M9N 1W4
    - Office of Dr Louis Yao
- Quebec
  - Chicoutimi, Quebec, Canada, G7H 7K9
    - Ecogene-21
  - Lévis, Quebec, Canada, G6W 0M5
    - Manna Research Incorporated
  - Montreal, Quebec, Canada, H2W 1R7
    - Institut de recherches cliniques de Montréal
  - Montreal, Quebec, Canada, H3G 1A4
    - McGill University Health Centre - Montreal General Hospital
  - Montreal, Quebec, Canada, H1T 3Y7
    - Clinique Sante Cardio MC
  - Montreal, Quebec, Canada, H4A 3T2
    - Applied Medical Informatics Research Incorporated
  - Québec, Quebec, Canada, G1V 4W2
    - Clinique des Maladies Lipidiques de Quebec Incorporated
  - Saint-Jérôme, Quebec, Canada, J7Z 5T3
    - Centre intégré de santé et de services sociaux (CISSS) des Laurentides - Unité de recherche clini
Cechia
- - Benátky nad Jizerou, Cechia, 294 71
    - MUDr Igor Karen
  - Beroun, Cechia, 266 01
    - Jessenia as, Nemocnice Beroun
  - Beroun, Cechia, 266 01
    - Medicentrum Beroun sro
  - Brandýs nad Labem, Cechia, 250 01
    - Medicus Services sro
  - Brno, Cechia, 625 00
    - Fakultni nemocnice Brno
  - Brno, Cechia, 636 00
    - Vojenska nemocnice Brno
  - Brno, Cechia, 602 00
    - Amkardia sro
  - Brno, Cechia, 602 00
    - CCR Brno sro
  - Brno, Cechia, 603 00
    - Centrum pro zdravi sro
  - Brno, Cechia, 612 00
    - Kardiologicka ambulance Brno sro
  - Brno, Cechia, 638 00
    - prof MUDr Lubomir Elbl, CSc, Kardiologicka ambulance
  - Broumov, Cechia, 550 01
    - Edumed sro, Kardiologicka ambulance
  - Havirov - Mesto, Cechia, 736 01
    - Dika centrum sro
  - Hodonín, Cechia, 695 01
    - Clinical Trial Center Hodonin sro
  - Holešov, Cechia, 769 01
    - Kardio Holesov sro
  - Hradec Králové, Cechia, 500 02
    - MUDr Ladislava Harrerova, kardiologicka ordinace
  - Karlovy Vary, Cechia, 360 01
    - Karlovarska krajska nemocnice
  - Kladno, Cechia, 272 59
    - Oblastni nemocnice Kladno as
  - Klatovy IV, Cechia, 339 01
    - Kardio Michal Cepelak sro
  - Kolin III, Cechia, 280 02
    - Oblastni nemocnice Kolin as
  - Liberec, Cechia, 460 63
    - Krajska nemocnice Liberec as
  - Louny, Cechia, 440 01
    - KardioBusak sro
  - Ludgeřovice, Cechia, 747 14
    - Kardio Pudich s.r.o.
  - Milevsko, Cechia, 399 01
    - Vseobecna intermi ambulance sro
  - Mladá Boleslav, Cechia, 293 01
    - MUDr Zbynek Kosek, kardiologicka ambulance sro
  - Mohelnice, Cechia, 789 85
    - Pozdisek sro, Kardiologicka ambulance
  - Ostrava, Cechia, 702 00
    - CCR Ostrava sro
  - Ostrava, Cechia, 728 80
    - Mestska nemocnice Ostrava
  - Ostrava - Poruba, Cechia, 708 00
    - Benedor sro - Kardiologicka, cevni a interni ambulance
  - Ostrava-Dubina, Cechia, 700 30
    - Kardiologicka a Angiologicka Ambulance
  - Pardubice, Cechia, 530 02
    - Center for Clinical Research Pardubice, sro
  - Pardubice, Cechia, 532 03
    - Nemocnice Pardubickeho kraje as
  - Pilsen, Cechia, 310 01
    - Kardiologie v sadech sro
  - Prague, Cechia, 128 08
    - Vseobecna fakultni nemocnice v Praze
  - Prague, Cechia, 140 59
    - Thomayerova nemocnice
  - Prague, Cechia, 150 06
    - Fakultni nemocnice v Motole
  - Prague, Cechia, 198 00
    - Endokrinologie Cerny Most sro
  - Prague, Cechia, 149 00
    - Milan Kvapil sro
  - Prague, Cechia, 101 00
    - Ordinace pro choroby srdce a cev
  - Prague, Cechia, 110 00
    - Diabet2 sro
  - Prague, Cechia, 130 00
    - CCR Prague sro
  - Prague, Cechia, 158 00
    - Interni a kardiologicka ordinace
  - Praha 10 - Zabehlice, Cechia, 106 00
    - Kardiologie Cor sro
  - Praha 5 - Smichov, Cechia, 150 00
    - Kardiologicke centrum MUDr Janky Skrobakove sro
  - Přerov, Cechia, 750 02
    - Kardio Vaclavik sro, Interni a kardiologicka ambulance
  - Rychnov nad Kněžnou, Cechia, 516 01
    - Vestra Clinics sro
  - Svitavy, Cechia, 568 25
    - Nemocnice Pardubickeho kraje as, Svitavska nemocnice
  - Teplice, Cechia, 415 01
    - AeskuLab ks, Lipidova poradna
  - Třinec, Cechia, 739 61
    - Nemocnice Podlesi as
  - Uherské Hradiště, Cechia, 686 01
    - Interni ambulance
  - Uherské Hradiště, Cechia, 686 01
    - Clinical Trials Service sro
  - Zlín, Cechia, 760 01
    - Lekarsky dum Ormiga
  - Znojmo, Cechia, 669 02
    - KIGE sro
  - České Budějovice, Cechia, 370 11
    - Cevni centrum Ceske Budejovice sro
Corea del Sud
- - Busan, Corea del Sud, 49201
    - Dong-A University Hospital
  - Busan, Corea del Sud, 47392
    - Inje University Busan Paik Hospital
  - Cheongju-si, Chungcheongbuk-do, Corea del Sud, 28644
    - Chungbuk National University Hospital
  - Daegu, Corea del Sud, 42415
    - Yeungnam University Medical Center
  - Daegu, Corea del Sud, 42601
    - Keimyung University, Dongsan Hospital
  - Gwangju, Corea del Sud, 501-757
    - Chonnam National University Hospital
  - Incheon, Corea del Sud, 21565
    - Gachon University Gil Medical Center
  - Seongnam-si, Gyeonggi-do, Corea del Sud, 13620
    - Seoul National University Bundang Hospital
  - Seoul, Corea del Sud, 03080
    - Seoul National University Hospital
  - Seoul, Corea del Sud, 05505
    - Asan Medical Center
  - Seoul, Corea del Sud, 06351
    - Samsung Medical Center
  - Seoul, Corea del Sud, 03181
    - Kangbuk Samsung Hospital
  - Seoul, Corea del Sud, 03722
    - Severance Hospital, Yonsei University Health System
  - Seoul, Corea del Sud, 06591
    - The Catholic University of Korea Seoul St Marys Hospital
  - Seoul, Corea del Sud, 02841
    - Korea University Anam Hospital
  - Seoul, Corea del Sud, 02447
    - Kyung Hee University Hospital
  - Seoul, Corea del Sud, 135-700
    - Gangnam Severance Hospital
  - Suwon-si, Gyeonggi-do, Corea del Sud, 16499
    - Ajou University Hospital
  - Wonju-si, Gangwon-do, Corea del Sud, 26426
    - Yonsei University Wonju Severance Christian Hospital
Danimarca
- - Aalborg, Danimarca, 9000
    - Aalborg Hospital
  - Aalborg, Danimarca, 9000
    - Center for Clinical and Basic Research Aalborg
  - Aarhus N, Danimarca, 8200
    - Aarhus Universitetshospital
  - Ballerup Municipality, Danimarca, 2750
    - Centre for Clinical and Basic Research Ballerup
  - Esbjerg, Danimarca, 6700
    - Sydvestjysk Sygehus
  - Herlev, Danimarca, 2730
    - Sanos Clinic
  - Herlev, Danimarca, 2730
    - Steno Diabetes Center
  - Herning, Danimarca, 7400
    - Regionhospitalet Herning
  - Hillerød, Danimarca, 3400
    - Hillerod Hospital
  - Kolding, Danimarca, 6000
    - Kolding Sygehus
  - København S, Danimarca, 2300
    - Amager Hospital
  - København Ø, Danimarca, 2100
    - Rigshospitalet Kobenhavn
  - Silkeborg, Danimarca, 8600
    - Regionshospitalet Silkeborg
  - Svendborg, Danimarca, 5700
    - Svendborg Sygehus
  - Vejle, Danimarca, 7100
    - Center for Clinical and Basic Research Vejle
  - Viborg, Danimarca, 8800
    - Regionshospitalet Viborg
Estonia
- - Pärnu, Estonia, 80014
    - Liina Viitas OÜ
  - Tallinn, Estonia, 13419
    - North Estonia Medical Centre Foundation
  - Tallinn, Estonia, 13419
    - Dr Arvo Rosenthal LLC
  - Tallinn, Estonia, 10128
    - Center for Clinical and Basic Research Tallinn
Finlandia
- - Helsinki, Finlandia, 00029
    - Helsinki University Central Hospital
  - Helsinki, Finlandia, 00100
    - GERI-MED Oy
  - Joensuu, Finlandia, 80210
    - Pohjois-Karjalan keskussairaala
  - Jyväskylä, Finlandia, 40620
    - StudyCor Oy
  - Jyväskylä, Finlandia, 40100
    - Terveystalo Jyvaskyla
  - Kuopio, Finlandia, 70210
    - University of Eastern Finland
  - Kuopio, Finlandia, 70100
    - Satucon Oy/Kuopion tyoterveys
  - Oulu, Finlandia, 90220
    - Oulu University Hospital
  - Oulu, Finlandia, 90029
    - Oulu University Hospital
  - Tampere, Finlandia, 33520
    - Tampere University Hospital
  - Turku, Finlandia, 20100
    - Terveystalo Pulssi
Francia
- - Amiens, Francia, 80054
    - Centre Hospitalier Universitaire Amiens - Hopital Sud
  - Bron, Francia, 69677
    - Hospices Civils de Lyon Groupement Hospitalier Est, Hopital Louis Pradel
  - Caen, Francia, 14033
    - Centre Hospitalier Universitaire de Caen - Hopital Cote de Nacre
  - Corbeil-Essonnes, Francia, 91106
    - Centre Hospitalier Sud Francilien
  - Dijon, Francia, 21079
    - Centre Hospitalier Universitaire de Dijon - Hopital Francois Mitterrand
  - Grenoble, Francia, 38700
    - Centre Hospitalier Universitaire de Grenoble - Hopital Nord Michallon
  - Grenoble, Francia, 38000
    - Groupement Hospitalier Mutualiste
  - Le Chesnay, Francia, 78150
    - Centre Hospitalier de Versailles - Hopital Andre Mignot
  - Le Coudray, Francia, 28630
    - Hôpital Louis Pasteur
  - Lille, Francia, 59037
    - Centre Hospitalier Régional Universitaire de Lille - Institut Coeur Poumon
  - Lyon Cédex 3, Francia, 69437
    - Centre Hospitalier Universitaire de Lyon - Hopital Edouard Herriot
  - Marseille, Francia, 13285
    - Hôpital Saint-Joseph
  - Marseille, Francia, 13385
    - Centre Hospitalier Universitaire de Marseille - Hôpital de la Timone
  - Montpellier, Francia, 34295
    - Centre Hospitalier Régional Universitaire de Montpellier - Hôpital Arnaud de Villeneuve
  - Nantes, Francia, 44093
    - Centre Hospitalier Universitaire de Nantes - Hopital Guillaume et Rene Laennec
  - Nice, Francia, 06002
    - Centre Hospitalier Universitaire de Nice - Hopital Pasteur
  - Nîmes, Francia, 30029
    - Centre Hospitalier Universitaire de Nîmes
  - Paris, Francia, 75015
    - Hôpital Europeén Georges Pompidou
  - Paris, Francia, 75012
    - Hopital Saint Antoine
  - Paris, Francia, 75018
    - Hopital Bichat Claude Bernard
  - Paris, Francia, 75013
    - Hôpital Pitié-Salpêtrière
  - Pau, Francia, 64000
    - Centre Hospitalier de Pau - Hôpital François Mitterrand
  - Rennes, Francia, 35033
    - Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou
  - Rouen, Francia, 76000
    - Clinique Saint Hilaire
  - Toulouse, Francia, 31076
    - Clinique Pasteur
  - Toulouse, Francia, 31059
    - Centre Hospitalier Universitaire de Toulouse - Hopital Rangueil
  - Valenciennes, Francia, 59300
    - Polyclinique Vauban
Germania
- - Bad Krozingen, Germania, 79189
    - Universitaets-Herzzentrum Freiburg - Bad Krozingen
  - Bad Neuheim, Germania, 61231
    - Kerckhoff-Klinik Forschungs GmbH
  - Berlin, Germania, 10787
    - Klinische Forschung Berlin GbR
  - Berlin, Germania, 13353
    - Charite Universitätsmedizin Berlin, Charité Campus Virchow-Klinikum
  - Bremen, Germania, 28277
    - Kardiologisch - Angiologische Praxis - Herzzentrum Bremen
  - Dortmund, Germania, 44137
    - Sankt-Johannes-Hospital
  - Dresden, Germania, 01277
    - Cardiologicum Dresden und Pirna
  - Dresden, Germania, 01279
    - Diabetologische Gemeinschaftspraxis Dr Schaper und Dr Faulmann
  - Dresden, Germania, 01307
    - Universitaetsklinikum Carl Gustav Carus, Medizinische Klinik und Poliklinik III
  - Frankfurt am Main, Germania, 60590
    - Klinikum und Fachbereich Medizin Johann Wolfgang Goethe-Universität Frankfurt am Main
  - Frankfurt am Main, Germania, 60596
    - Clin Phenomics GmbH Co KG
  - Fulda, Germania, 36037
    - Medizinisches Versorgungszentrum im Altstadt-Carree Fulda
  - Hamburg, Germania, 22041
    - Cardiologicum Hamburg
  - Heidelberg, Germania, 69120
    - Universitatsklinikum Heidelberg
  - Kassel, Germania, 34121
    - Ambulantes Herzzentrum Kassel
  - Leipzig, Germania, 4103
    - Universitatsklinikum Leipzig
  - Magdeburg, Germania, 39120
    - Otto von Guericke Universität Magdeburg
  - Mainz, Germania, 55131
    - Johannes Gutenberg Universitaet Mainz
  - Mannheim, Germania, 68167
    - Universitätsklinikum Mannheim
  - Markleeberg, Germania, 04416
    - Praxis Doktor Jens Taggeselle
  - München, Germania, 80636
    - Deutsches Herzzentrum München des Freistaates Bayern
  - München, Germania, 80638
    - Herz Gefaess Zentrum Nymphenburg
  - Münster, Germania, 48149
    - Universitaetsklinikum Muenster
  - Papenburg, Germania, 26871
    - Kardiologische Gemeinschaftspraxis Papenburg
  - Potsdam, Germania, 14467
    - Klinikum Ernst von Bergmann gGmbH
  - Regensburg, Germania, 93053
    - Universitätsklinikum Regensburg
  - Rostock, Germania, 18059
    - CardioConsil GmbH
  - Singen, Germania, 78224
    - I Medizinische Klinik Gesundheitsverbund Landkreis Konstanz
  - Ulm, Germania, 89081
    - Universitätsklinikum Ulm
  - Villingen-Schwenningen, Germania, 78052
    - Nephrologisches Zentrum Villingen-Schwenningen
  - Witten, Germania, 58455
    - Forschungszentrum Ruhr
Grecia
- - Athens, Grecia, 11527
    - General Hospital of Athens Laiko
  - Athens, Grecia, 15123
    - Hygeia Hospital
  - Athens, Grecia, 11528
    - Alexandra Hospital
  - Athens, Grecia, 11527
    - General Hospital of Athens Georgios Gennimatas
  - Athens, Grecia, 10676
    - General Hospital of Athens Evaggelismos
  - Athens, Grecia, 11521
    - Athens Naval Hospital
  - Athens, Grecia, 11527
    - General Hospital of Athens Ippokrateio
  - Athens, Grecia, 14233
    - Konstantopoulio - Agia Olga Hospital of Nea Ionia
  - Heraklion, Grecia, 71110
    - University Hospital of Heraklion
  - Ioannina, Grecia, 45500
    - University Hospital of Ioannina
  - Larissa, Grecia, 41110
    - University Hospital of Larissa
  - Thessaloniki, Grecia, 56403
    - Papageorgiou General Hospital of Thessaloniki
  - Thessaloniki, Grecia, 54636
    - Ahepa University Hospital
  - Thessaloniki, Grecia, 54636
    - General Hospital of Thessaloniki Ahepa
  - Thessaloniki, Grecia, 57001
    - Interbalkan Medical Center
Islanda
- - Kopavogur, Islanda, 201
    - Hjartamidstodin
  - Reykjavik, Islanda, 101
    - Landspitali
Italia
- - Augusta, Italia, 96011
    - Ospedale Muscatello
  - Bergamo, Italia, 24127
    - Azienda Socio Sanitaria Territoriale Papa Giovanni xxiii
  - Bologna, Italia, 40138
    - Azienda Ospedaliero Universitaria di Bologna Policlinico S Orsola Malpighi
  - Catanzaro, Italia, 88100
    - Azienda Ospedaliero Universitaria Mater Domini
  - Chieti, Italia, 66100
    - Universita degli Studi Gabriele D Annunzio di Chieti e Pescara
  - Massa, Italia, 54100
    - Fondazione Toscana Gabriele Monasterio Ospedale del Cuore G Pasquinucci
  - Milan, Italia, 20138
    - Centro Cardiologico Monzino
  - Milan, Italia, 20132
    - IRCCS Ospedale San Raffaele
  - Milan, Italia, 20162
    - Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
  - Pisa, Italia, 56100
    - Azienda Ospedaliero Universitaria Pisana
  - Pozzuoli, Italia, 80078
    - Presidio Ospedaliero Santa Maria Delle Grazie
  - Roma, Italia, 00189
    - Azienda Ospedaliera Sant Andrea
  - Roma, Italia, 00128
    - Policlinico Universitario Campus Biomedico
  - San Donato Milanese, Italia, 20097
    - IRCCS Policlinico San Donato
  - Torino, Italia, 10126
    - Azienda Ospedaliera Citta Della Salute E Della Scienza Di Torino
  - Udine, Italia, 33100
    - Azienda Ospedaliero Universitaria Integrata di Udine
Lettonia
- - Daugavpils, Lettonia, 5417
    - Daugavpils Regional Hospital
  - Ogre, Lettonia, 5001
    - Dace Teterovska Doctor Practice in Endocrinology
  - Ogre, Lettonia, 5001
    - Inga Jasinkevica Cardiologist Practice
  - Riga, Lettonia, 1002
    - Pauls Stradins Clinical University Hospital
  - Riga, Lettonia, 1012
    - Outpatient clinic Veselibas Centrs 4
Lituania
- - Alytus, Lituania, 63200
    - Klinikiniai sprendimai, UAB
  - Kaunas, Lituania, 50009
    - Hospital of Lithuanian University of Health Sciences Kaunas Clinics Public Institution
  - Kaunas, Lituania, 49387
    - Klinikiniai sprendimai, UAB
  - Kaunas, Lituania, 49456
    - Saules Seimos Medicinos Centras
  - Klaipėda, Lituania, 91131
    - Kardiologijos ir reabilitacijos klinika, UAB
  - Vilnius, Lituania, 08661
    - Vilnius University Hospital Santaros Clinic Public Institution
  - Šiauliai, Lituania, 76231
    - Siauliai Republican Hospital, Public Institution
Messico
- - Aguascalientes, Messico, 20230
    - Centro de investigacion Cardiometabolica
  - Chihuahua City, Messico, 31203
    - SCIENTIA Investigacion Clinica SC
- Mexico City
  - Cd de Mexico, Mexico City, Messico, 06700
    - Clinstile SA de CV
- Nuevo León
  - Monterrey, Nuevo León, Messico, 64460
    - Unidad Biomédica Avanzada Monterrey
- Querétaro
  - Querétaro City, Querétaro, Messico, 76000
    - Centro de Estudios Clinicos de Queretaro
- Sinaloa
  - Culiacán, Sinaloa, Messico, 80230
    - Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada SC
Olanda
- - Alkmaar, Olanda, 1815 JD
    - Noordwest Ziekenhuisgroep
  - Almelo, Olanda, 7609 PP
    - Ziekenhuisgroep Twente
  - Almere Stad, Olanda, 1311 RL
    - Emotional Brain
  - Amersfoort, Olanda, 3813 TZ
    - Meander Medisch Centrum
  - Amsterdam, Olanda, 1105 AZ
    - Academisch Medisch Centrum
  - Amsterdam, Olanda, 1091 AC
    - Onze Lieve Vrouwe Gasthuis
  - Amsterdam, Olanda, 1061 AE
    - Onze Lieve Vrouwe Gasthuis
  - Apeldoorn, Olanda, 7334 DZ
    - Gelre Ziekenhuis
  - Arnhem, Olanda, 6815 AD
    - Rijnstate Ziekenhuis
  - Beverwijk, Olanda, 1942 LE
    - Rode Kruis Ziekenhuis
  - Breda, Olanda, 4818 CK
    - Amphia Ziekenhuis
  - Delft, Olanda, 2625 AD
    - Reinier de Graaf Gasthuis
  - Deventer, Olanda, 7416 SE
    - Deventer Ziekenhuis
  - Dirksland, Olanda, 3247 BW
    - Van Weel Bethesda Ziekenhuis
  - Dordrecht, Olanda, 3318 AT
    - Albert Schweitzer Ziekenhuis, Locatie Dordwijk
  - Dordrecht, Olanda, 3318 AT
    - Albert Schweitzer Ziekenhuis location Dordwijk
  - Ede, Olanda, 6716 RP
    - Ziekenhuis Gelderse Vallei
  - Eindhoven, Olanda, 5623 EJ
    - Catharina Ziekenhuis
  - Emmen, Olanda, 7824 AA
    - Treant Zorggroep, locatie Scheper ziekenhuis Emmen
  - Enschede, Olanda, 7512 KZ
    - Medisch Spectrum Twente
  - Goes, Olanda, 4462 RA
    - Admiraal de Ruyter Ziekenhuis
  - Gouda, Olanda, 2803 HH
    - Groene Hart Ziekenhuis
  - Groningen, Olanda, 9728 NT
    - Martini Ziekenhuis
  - Harderwijk, Olanda, 3844 DG
    - Sint Jansdal Ziekenhuis
  - Heerlen, Olanda, 6419 PC
    - Zuyderland Medisch Centrum
  - Helmond, Olanda, 5707 HA
    - Elkerliek Ziekenhuis
  - Hilversum, Olanda, 1213 XZ
    - Tergooi
  - Hoogeveen, Olanda, 7909 AA
    - Bethesda Diabetes Research Center
  - Hoorn, Olanda, 1624 NP
    - Dijklander Ziekenhuis Hoorn
  - Leeuwarden, Olanda, 8934 AD
    - Medisch Centrum Leeuwarden
  - Leiden, Olanda, 2333 ZA
    - Leids Universitair Medisch Centrum
  - Meppel, Olanda, 7943 KA
    - Isala Diaconessenhuis
  - Nieuwegein, Olanda, 3435 CM
    - Sint Antonius Ziekenhuis, locatie Nieuwegein
  - Nijmegen, Olanda, 6525 GA
    - Radboudumc
  - Nijmegen, Olanda, 6532 SZ
    - Canisius-Wilhelmina Ziekenhuis
  - Rotterdam, Olanda, 3083 AN
    - Ikazia Ziekenhuis
  - Rotterdam, Olanda, 3079 DZ
    - Maasstad ziekenhuis
  - Rotterdam, Olanda, 3045 PM
    - Franciscus Gasthuis
  - Rotterdam, Olanda, 3067 GJ
    - Praktijk Soerland
  - Schiedam, Olanda, 3118 JH
    - Franciscus Vlietland
  - Sneek, Olanda, 8601 ZR
    - D&A Research and Genetics
  - The Hague, Olanda, 2545 AA
    - Haga Ziekenhuis
  - The Hague, Olanda, 2572 GM
    - Huisartsenpraktijk Rambharose
  - Tiel, Olanda, 4002 WP
    - Ziekenhuis Rivierenland
  - Tilburg, Olanda, 5042 AD
    - Elisabeth-TweeSteden Ziekenhuis
  - Uden, Olanda, 5406 PT
    - Ziekenhuis Bernhoven
  - Utrecht, Olanda, 3584 CX
    - Universitair Medisch Centrum Utrecht
  - Utrecht, Olanda, 3582 KE
    - Diakonessenhuis
  - Venlo, Olanda, 5912 BL
    - VieCuri Medisch Centrum
  - Zaandam, Olanda, 1502 DV
    - Zaans Medisch Centrum
  - Zwijndrecht, Olanda, 3331 LZ
    - Albert Schweitzer ziekenhuis
  - Zwijndrecht, Olanda, 3334 SB
    - Dokters van Nederhoven
  - Zwolle, Olanda, 8025 AB
    - Isala Klinieken
Polonia
- - Bydgoszcz, Polonia, 85-094
    - Szpital Uniwersytecki nr 1 im dr Antoniego Jurasza w Bydgoszczy
  - Chrzanów, Polonia, 32-500
    - American Heart of Poland Sa Malopolskie Centrum Sercowo-Naczyniowe PAKS - Chrzanow
  - Gdansk, Polonia, 80-219
    - Uniwersyteckie Centrum Kliniczne
  - Gdansk, Polonia, 80-462
    - Copernicus Podmiot Leczniczy Sp zoo
  - Gdynia, Polonia, 81-394
    - NZOZ Srodmiescie Spzoo
  - Gdynia, Polonia, 81-472
    - Marek Piepiorka Gabinet Kardiologiczno-Internistyczny
  - Giżycko, Polonia, 11-500
    - Spolka Cywilna Medicina
  - Grodzisk Mazowiecki, Polonia, 05-825
    - Samodzielny Publiczny Specjalistyczny Szpital Zachodni im swietego Jana Pawla II
  - Józefów, Polonia, 05-410
    - Biokinetica SA
  - Katowice, Polonia, 40-081
    - Centrum Medyczne Pratia Katowice
  - Kielce, Polonia, 25-525
    - Specjalistyczna Poradnia Kardiologiczna i Nadcisnienia Tetniczego Beata Wozakowska-Kaplon
  - Kielce, Polonia, 25-736
    - Wojewodzki Szpital Zespolony w Kielcach
  - Krakow, Polonia, 30-082
    - Ewa Mirek-Bryniarska Specjalistyczna Praktyka Lekarska
  - Krakow, Polonia, 31-135
    - Zespol Przychodni Specjalistycznych Diab-End-Cor Sp z oo
  - Krakow, Polonia, 31-501
    - Krakowskie Centrum Medyczne Spzoo
  - Krakow, Polonia, 31-514
    - CARINTART Sp zoo Krakowskie Centrum Diagnostyczno-Kliniczne
  - Krosno, Polonia, 38-400
    - Intercard Spzoo Centrum Kardiologii Inwazyjnej Elektroterapii i Angiologii w Krosnie
  - Lodz, Polonia, 93-338
    - Instytut Centrum Zdrowia Matki Polki
  - Lodz, Polonia, 91-347
    - Wojewodzki Specjalistyczny Szpital im dr Wladyslawa Bieganskiego w Lodzi
  - Lubin, Polonia, 59-300
    - Miedziowe Centrum Zdrowia Spolka Akcyjna
  - Lublin, Polonia, 20-362
    - KO-MED Centra Kliniczne Lublin II
  - Lublin, Polonia, 20-044
    - CenterMed Lublin Spzoo
  - Lublin, Polonia, 20-078
    - Clinical Best Solutions Sp zoo Spolka Komandytowa Gabinet Lekarski
  - Lublin, Polonia, 20-857
    - NZOZ Twoja Przychodnia Spzoo
  - Miechów, Polonia, 32-200
    - Szpital Swietej Anny w Miechowie
  - Nowy Targ, Polonia, 34-400
    - Podhalanski Szpital Specjalistyczny im Jana Pawla II w Nowym Targu
  - Piaseczno, Polonia, 05-500
    - Centrum Medyczne Pulawska spzoo Centrum Medyczne Pulawska NZOZ
  - Poznan, Polonia, 60-848
    - Clinical Research Center Spzoo Medic-R Spolka Komandytowa
  - Puławy, Polonia, 24-100
    - KO-MED Centra Kliniczne Spzoo KO-MED Centra Kliniczne Pulawy
  - Płock, Polonia, 09-402
    - NZOZ Specjalistyczna Przychodnia Lekarska Medikard
  - Ruda Śląska, Polonia, 41-709
    - NZOZ Przychodnia Specjalistyczna Andrzej Wittek Henryk Rudzki spolka jawna
  - Siedlce, Polonia, 08-110
    - Clinical Best Solutions Spolka z ograniczona odpowiedzialnoscia Spolka komandytowa
  - Skierniewice, Polonia, 96-100
    - ETG Network Spzoo
  - Staszów, Polonia, 28-200
    - KO-MED Centra Kliniczne Spzoo KO-MED Centra Kliniczne Staszow
  - Szczecin, Polonia, 70-506
    - Indywidualna Specjalistyczna Praktyka Lekarska
  - Tarnów, Polonia, 33-100
    - Centrum Szybkiej Diagnostyki Kardiologicznej Kardiomed M Zabowka E Zabowka Spolka cywilna
  - Torun, Polonia, 87-100
    - Medical Trials Institute Spzoo
  - Torun, Polonia, 87-100
    - Prywatne Centrum Kardiologii
  - Torun, Polonia, 87-100
    - Wojewodzki Szpital Zespolony im Ludwika Rydygiera w Toruniu
  - Warsaw, Polonia, 02-957
    - Instytut Psychiatrii i Neurologii
  - Warsaw, Polonia, 01-868
    - Centrum Medyczne Pratia Warszawa
  - Warsaw, Polonia, 01-518
    - Centrum Medyczne Amed Warszawa Zoliborz
  - Warsaw, Polonia, 02-793
    - Clinical Best Solutions Sp zoo Spolka komandytowa
  - Warsaw, Polonia, 04-073
    - Szpital Grochowski imienia Doktora medycyny Rafala Masztaka Spzoo
  - Wroclaw, Polonia, 51-162
    - Centrum Badan Klinicznych Piotr Napora lekarze spolka partnerska
  - Wroclaw, Polonia, 50-088
    - Futuremeds Spolka z ograniczona odpowiedzialnoscia
  - Wroclaw, Polonia, 50-315
    - Centrum Kardiologiczne Pro Corde Spzoo Centrum Kardiologicne Pro Corde Wroclaw
  - Węgrów, Polonia, 07-100
    - Samodzielny Publiczny Zaklad Opieki Zdrowotnej w Wegrowie
  - Włocławek, Polonia, 87-800
    - Medicor Plus Kardiolodzy Spzoo
  - Zamość, Polonia, 22-400
    - KO-MED Centra Kliniczne Spzoo KO-MED Centra Kliniczne Zamosc
  - Łęczna, Polonia, 21-010
    - Samodzielny Publiczny Zakład Opieki Zdrowotnej w Lecznej
  - Świdnik, Polonia, 21-040
    - Tomasz Blicharski Lubelskie Centrum Diagnostyczne
Portogallo
- - Almada, Portogallo, 2801-951
    - Hospital Garcia de Orta, EPE
  - Aveiro, Portogallo, 3814-501
    - Centro Hospitalar do Baixo Vouga, EPE - Hospital Infante Dom Pedro
  - Carnaxide, Portogallo, 2790-134
    - Centro Hospitalar de Lisboa Ocidental, EPE - Hospital de Santa Cruz
  - Coimbra, Portogallo, 3000-075
    - Centro Hospitalar E Universitário de Coimbra EPE
  - Faro, Portogallo, 8000-386
    - Hospital de Faro, EPE
  - Guimarães, Portogallo, 4835-044
    - Hospital da Senhora da Oliveira, Guimaraes, EPE
  - Lisbon, Portogallo, 1250-189
    - Associação Protectora dos Diabéticos de Portugal
  - Matosinhos Municipality, Portogallo, 4464-513
    - Unidade Local de Saude de Matosinhos - Hospital Pedro Hispano
  - Viseu, Portogallo, 3500-093
    - Hospital Casa de Saude Sao Mateus
Regno Unito
- - Aberdeen, Regno Unito, AB25 2ZN
    - Aberdeen Royal Infirmary
  - Barnsley, Regno Unito, S75 2EP
    - Barnsley Hospital
  - Bath, Regno Unito, BA1 3NG
    - Royal United Hospital
  - Belfast, Regno Unito, BT16 1RH
    - Ulster Hospital
  - Belfast, Regno Unito, BT12 6BA
    - Royal Victoria Hospital
  - Belfast, Regno Unito, BT7 2EB
    - Ormeau Health Centre
  - Bollington, Regno Unito, SK10 5JH
    - Bollington Medical Centre
  - Bournemouth, Regno Unito, BH7 7DW
    - Royal Bournemouth Hospital
  - Bristol, Regno Unito, BS37 4AX
    - West Walk Surgery
  - Burton-on-Trent, Regno Unito, DE13 0RB
    - University Hospitals of Derby and Burton NHS Foundation Trust
  - Chesterfield, Regno Unito, S40 4AA
    - Ashgate Medical Practice
  - Cleveleys, Regno Unito, FY5 3LF
    - Cleveleys Group Practice
  - Corby, Regno Unito, NN17 2UR
    - Lakeside Healthcare
  - Corby, Regno Unito, NN18 9EZ
    - Medinova Northamptonshire Dedicated Research Site
  - Coventry, Regno Unito, CV3 4FJ
    - MeDiNova Warwickshire Quality Research Site
  - Crawley, Regno Unito, RH10 7DX
    - Pound Hill Medical Group
  - Dundee, Regno Unito, DD1 9SY
    - Ninewells Hospital
  - Glasgow, Regno Unito, G31 2ER
    - Glasgow Royal Infirmary
  - Hull, Regno Unito, HU3 2RW
    - Hull Royal Infirmary
  - Inverness, Regno Unito, IV2 3JH
    - Highlands Clinical Research Facility, Raigmore Hospital
  - Liverpool, Regno Unito, L7 8XP
    - Royal Liverpool University Hospital
  - London, Regno Unito, NW3 2QG
    - Royal Free London NHS Foundation Trust
  - London, Regno Unito, SE1 9RT
    - Guys Hospital
  - London, Regno Unito, EC1M 6BQ
    - Barts Health NHS Trust
  - Manchester, Regno Unito, M23 9LT
    - Wythenshawe Hospital
  - Northwood, Regno Unito, HA6 2RN
    - Medinova North London Dedicated Research Centre
  - Nottingham, Regno Unito, NG5 1PB
    - Nottingham City Hospital
  - Nuneaton, Regno Unito, CV10 7DJ
    - George Eliot Hospital
  - Orpington, Regno Unito, BR5 3QG
    - Medinova South London Dedicated Research Centre
  - Penzance, Regno Unito, TR19 7HX
    - Mounts Bay Medical Hub
  - Peterborough, Regno Unito, PE7 1AT
    - The Health Centre Yaxley
  - Poole, Regno Unito, BH16 5PW
    - The Adam Practice
  - Romford, Regno Unito, RM1 3PJ
    - Medinova East London Dedicated Research Centre
  - Royal Leamington Spa, Regno Unito, CV32 4RA
    - Sherbourne Medical Centre
  - Saint Neots, Regno Unito, PE19 8BB
    - Eaton Socon Health Centre
  - Sandbach, Regno Unito, CW11 1EQ
    - Ashfield Primary Care Centre
  - Scunthorpe, Regno Unito, DN15 7BH
    - Scunthorpe General Hospital
  - Shipley, Regno Unito, BD18 3SA
    - Medinova Limited
  - Stamford, Regno Unito, PE9 2DH
    - Lakeside Healthcare Stamford
  - Stevenage, Regno Unito, SG1 4AB
    - Lister Hospital
  - Swansea, Regno Unito, SA2 8PP
    - Singleton Hospital
  - Thetford, Regno Unito, IP24 1JD
    - The Breckland Alliance
  - Torquay, Regno Unito, TQ2 7AA
    - Torbay Hospital
  - Wakefield, Regno Unito, WF1 4DG
    - Pinderfields Hospital
  - Watford, Regno Unito, WD25 7NL
    - Sheepcot Medical Practice
  - West Bromwich, Regno Unito, B71 4HJ
    - Sandwell General Hospital
  - Whitby, Regno Unito, YO21 1SD
    - Whitby Group Practice
  - Wokingham, Regno Unito, RG40 1XS
    - MeDiNova West London Quality Research Site
  - Worcester, Regno Unito, WR5 1DD
    - Worcestershire Royal Hospital
  - Yeovil, Regno Unito, BA21 4AT
    - Yeovil District Hospital
Romania
- - Brasov, Romania, 500283
    - SC Centrul Medical de Diagnostic si Tratament Ambulator Neomed S.R.L
  - Bucharest, Romania, 050098
    - Spitalul Universitar de Urgenta Bucuresti
  - Bucharest, Romania, 011461
    - Spitalul Clinic Universitar de Urgenta Elias
  - Bucharest, Romania, 022328
    - Institutul de Urgenţă pentru Boli Cardiovasculare "Prof. Dr. C. C. Iliescu",
  - Craiova, Romania, 200512
    - Cardiomed SRL
  - Iași, Romania, 700547
    - Consultmed SRL
  - Iași, Romania, 700732
    - SC Cardiomed SRL
  - Oradea, Romania, 410151
    - SC Endodigest SRL
  - Piteşti, Romania, 110438
    - Sc Sal Med Srl
  - Târgu Mureş, Romania, 540143
    - Cmi Dr Podoleanu Cristian
  - Târgu Mureş, Romania, 540142
    - Mediab SRL
Russia
- - Arkhangelsk, Russia, 163001
    - First City Clinical Hospital na E E Volosevich
  - Barnaul, Russia, 656038
    - NSHI Departmental Hospital at the station Barnaul of OJSC Russian Railways
  - Barnaul, Russia, 656055
    - Regional State Budget Health care Institution Altay Regional Cardiology Dispensary
  - Ivanovo, Russia, 153012
    - Regional Budget Healthcare Institution Cardiology Dispensary
  - Izhevsk, Russia, 426063
    - BHI of Republic Udmurtiya City clinical hospital 9 of Ministry of healthcare of Republic Udmurtiya
  - Kemerovo, Russia, 650002
    - FSBI Heart and Vessels Diseases complex problems Scientific Research Institution
  - Kirov, Russia, 610014
    - Kirov Regional State Budget Healthcare Institution Kirov City Clinical Hospital 1
  - Krasnodar, Russia, 350012
    - Regional Clinical Hospital 2 of the Ministry of Health Krasnodar region
  - Krasnodar, Russia, 350086
    - SBHI Scientific Research Institute Regional Clinical Hospital 1 named after S V Ochapovsky
  - Moscow, Russia, 101990
    - National Medical Research Center for therapy and preventive medicine
  - Moscow, Russia, 111539
    - Moscow SBHI City Clinical Hospital 15 n a O M Filatov of Moscow Healthcare Department
  - Moscow, Russia, 117292
    - SBHI of Moscow City clinical hospital 64 of Moscow Healthcare department
  - Moscow, Russia, 121374
    - City Clinical Hospital named after Zhadkevich
  - Moscow, Russia, 121552
    - FSBI Russian Cardiology Research and Production Complex
  - Nizhny Novgorod, Russia, 603126
    - SBHI of Nizhny Novgorod region Nizhny Novgorod regional clinical hospital na N A Semashko
  - Novosibirsk, Russia, 630005
    - LLC RC Medical
  - Novosibirsk, Russia, 630047
    - SBHI of Novosibirsk Region City clinical hospital 1
  - Novosibirsk, Russia, 630089
    - FSBSI Scientific Research Institute of Therapy and preventive medicine
  - Omsk, Russia, 644018
    - Budget Healthcare Institution of Omsk region Medical-sanitary unit 9
  - Perm, Russia, 614097
    - Perm Regional Hospital for War Veterans
  - Ryazan, Russia, 390039
    - State Budget Institution of Ryazan Region Regional Clinical Hospital
  - Saint Petersburg, Russia, 190031
    - City Polyclinic 27
  - Saint Petersburg, Russia, 192283
    - Saint Petersburg State Budget Healthcare Institution City Polyclinic 109
  - Saint Petersburg, Russia, 192289
    - Saint Petersburg State Budget Healthcare Institution City Polyclinic 109
  - Saint Petersburg, Russia, 193312
    - City polyclinic 25 Nevsky district
  - Saint Petersburg, Russia, 195112
    - SBHI Medical and sports dispensary of Krasnogvardeisky district of Saint Petersburg
  - Saint Petersburg, Russia, 196601
    - Saint Petersburg SBHI City Hospital 38 named after N A Semashko
  - Saint Petersburg, Russia, 197341
    - Almazov National Medical Research Centre
  - Saint Petersburg, Russia, 199106
    - Saint Petersburg State Budget Healthcare Institution Pokrovskaya City Hospital
  - Saint Petersburg, Russia, 199178
    - LLC Mart
  - Sait-Petersburg, Russia, 194044
    - LLC Medinef Clinic
  - Samara, Russia, 443070
    - Samara Regional Clinical Cardiology Dispensary
  - Saratov, Russia, 410054
    - Clinical Hospital named after S R Mirotvortsev
  - Smolensk, Russia, 214018
    - Regional State Budget Helthcare Institution Smolensk Regional Clinical Hospital
  - Sochi, Russia, 354057
    - State Budgetary Health Institution City Hospital 4 of the City of Sochi
  - Tomsk, Russia, 634012
    - FSBSI Tomsk National Research Medical Center of the Russian Academy of Sciences
  - Tyumen, Russia, 625023
    - Tyumen State Medical University
  - Tyumen, Russia, 625032
    - State Autonomous Healthcare Institution of the Tyumen region Medical Scientific Practical Center
  - Vladimir, Russia, 600020
    - SBHI of Vladimirskaya region City Hospital 4 of Vladimir
  - Volgograd, Russia, 400001
    - Family Medicine Clinic
  - Yekaterinburg, Russia, 620026
    - Central City Clinical Hospital 1 of the Oktyabrsky District
  - Yekaterinburg, Russia, 620102
    - State Budget Medical Institution Sverdlovsk Regional Clinical Hospital N1
Slovacchia
- - Bardejov, Slovacchia, 085 01
    - Alian, sro
  - Bratislava, Slovacchia, 831 03
    - MediTask, sro
  - Bratislava, Slovacchia, 833 48
    - Narodny ustav srdcovych a cievnych chorob, as
  - Bratislava, Slovacchia, 851 01
    - Veria, sro
  - Brezno, Slovacchia, 977 01
    - Nemocnica s poliklinikou Brezno, no
  - Košice, Slovacchia, 040 01
    - Medical group Kosice sro
  - Košice, Slovacchia, 040 22
    - Cardio D and R, sro Kosice
  - Lučenec, Slovacchia, 984 01
    - Kardio 1 sro
  - Moldava nad Bodvou, Slovacchia, 045 01
    - Medi M and M sro
  - Nitra, Slovacchia, 949 01
    - Kardiocentrum Nitra sro
  - Nové Zámky, Slovacchia, 940 01
    - Kardiomed NZ, sro
  - Námestovo, Slovacchia, 029 01
    - Oralek, sro
  - Prešov, Slovacchia, 080 01
    - Medikard, sro
  - Prešov, Slovacchia, 080 01
    - Medispol, sro
  - Rožňava, Slovacchia, 048 01
    - DIAB sro
  - Snina, Slovacchia, 069 01
    - Mediluk sro
  - Svidník, Slovacchia, 089 01
    - Interna SK, sro
  - Trebišov, Slovacchia, 075 01
    - Areteus sro
  - Trenčín, Slovacchia, 911 01
    - CardiOr, sro
Spagna
- - Madrid, Spagna, 28040
    - Fundación Jiménez Díaz
  - Madrid, Spagna, 28040
    - Hospital Clinico San Carlos
  - Madrid, Spagna, 28041
    - Hospital Universitario 12 de Octubre
  - Madrid, Spagna, 28046
    - Hospital Universitario La Paz
  - Madrid, Spagna, 28006
    - Hospital Universitario de La Princesa
  - Madrid, Spagna, 28702
    - Hospital Universitario Infanta Sofía
- Andalusia
  - Almería, Andalusia, Spagna, 04120
    - Hospital Virgen del Mar
  - Córdoba, Andalusia, Spagna, 14004
    - Hospital Universitario Reina Sofia
  - Granada, Andalusia, Spagna, 18012
    - Hospital Universitario Virgen de las Nieves
  - Málaga, Andalusia, Spagna, 29010
    - Hospital Clinico Universitario Virgen de La Victoria
  - Seville, Andalusia, Spagna, 41009
    - Hospital Universitario Virgen Macarena
- Aragon
  - Zaragoza, Aragon, Spagna, 50009
    - Hospital Universitario Miguel Servet
- Canary Islands
  - Las Palmas de Gran Canarias, Canary Islands, Spagna, 35010
    - Hospital Universitario de Gran Canaria Doctor Negrin
- Castille and León
  - Valladolid, Castille and León, Spagna, 47005
    - Hospital Clínico Universitario de Valladolid
- Catalonia
  - Badalona, Catalonia, Spagna, 08916
    - Hospital Universitari Germans Trias i Pujol
  - Barcelona, Catalonia, Spagna, 08036
    - Hospital Clinic i Provincial de Barcelona
  - Barcelona, Catalonia, Spagna, 08025
    - Equip Atencio Primaria Sardenya
  - Reus, Catalonia, Spagna, 43204
    - Hospital Universitari Sant Joan de Reus
- Galicia
  - A Coruña, Galicia, Spagna, 15006
    - Complexo Hospitalario Universitario A Coruña
  - Santiago de Compostela, Galicia, Spagna, 15706
    - Hospital Clínico Universitario de Santiago
  - Vigo, Galicia, Spagna, 36312
    - Hospital Alvaro Cunqueiro
- Murcia
  - El Palmar, Murcia, Spagna, 30120
    - Hospital Universitario Virgen de la Arrixaca
- Navarre
  - Pamplona, Navarre, Spagna, 31008
    - Complejo Hospitalario de Navarra
- Valencia
  - Valencia, Valencia, Spagna, 46010
    - Hospital Clínico Universitario de Valencia
  - Valencia, Valencia, Spagna, 26026
    - Hospital Universitari i Politecnic La Fe
Stati Uniti
- Alabama
  - Athens, Alabama, Stati Uniti, 35611
    - North Alabama Research Center LLC
  - Birmingham, Alabama, Stati Uniti, 35243
    - Cardiovascular Associates
  - Huntsville, Alabama, Stati Uniti, 35801
    - Heart Center Research LLC
  - Mobile, Alabama, Stati Uniti, 36608
    - Mobile Heart Specialists PC
- Arkansas
  - Little Rock, Arkansas, Stati Uniti, 72205
    - Central Arkansas Veterans Healthcare System
  - Little Rock, Arkansas, Stati Uniti, 72205
    - Arkansas Cardiology
- California
  - Beverly Hills, California, Stati Uniti, 90211
    - Westside Medical Associates of Los Angeles
  - Beverly Hills, California, Stati Uniti, 90210
    - Cardiovascular Research Foundation of Southern California
  - Dublin, California, Stati Uniti, 94568
    - West Coast Research LLC
  - Palm Springs, California, Stati Uniti, 92262
    - Desert Oasis Healthcare Medical Group
  - Riverside, California, Stati Uniti, 92506
    - Covigilant Research, LLC
  - Roseville, California, Stati Uniti, 95661
    - Sierra Clinical Research
  - Sacramento, California, Stati Uniti, 95823
    - Center for Clinical Trials of Sacramento Inc
  - Torrance, California, Stati Uniti, 90502
    - Harbor University of California Los Angeles Medical Center
- Colorado
  - Colorado Springs, Colorado, Stati Uniti, 80906
    - Optumcare Colorado Springs LLC
  - Colorado Springs, Colorado, Stati Uniti, 80909
    - University of Colorado Memorial Health System
  - Golden, Colorado, Stati Uniti, 80401
    - New West Physicians
  - Littleton, Colorado, Stati Uniti, 80120
    - South Denver Cardiology Associates
- Connecticut
  - Stamford, Connecticut, Stati Uniti, 06905
    - Cardiology Associates of Fairfield County, PC
- Florida
  - Boca Raton, Florida, Stati Uniti, 33434
    - Excel Medical Clinical Trials
  - Brandon, Florida, Stati Uniti, 33511
    - Bay Area Cardiology
  - Crystal River, Florida, Stati Uniti, 34429
    - Nature Coast Clinical Research LLC
  - Daytona Beach, Florida, Stati Uniti, 32114
    - Daytona Heart Group
  - Daytona Beach, Florida, Stati Uniti, 32117
    - Cardiology Research Associates
  - DeLand, Florida, Stati Uniti, 32720
    - Complete Health Research
  - Delray Beach, Florida, Stati Uniti, 33446
    - Cohen Medical Associates PA
  - Fort Lauderdale, Florida, Stati Uniti, 33312
    - Jellinger and Lerman MD PA dba The Center for Diabetes and Endocrine Care
  - Green Cove Springs, Florida, Stati Uniti, 32043
    - George E Platt MD
  - Hollywood, Florida, Stati Uniti, 33021
    - Research Physicians Network Alliance
  - Jacksonville, Florida, Stati Uniti, 32216
    - Jacksonville Center for Clinical Research
  - Jacksonville, Florida, Stati Uniti, 32209
    - University of Florida and Shands Hospital
  - Jacksonville, Florida, Stati Uniti, 32256
    - First Coast Cardiovascular Institute PA
  - Jacksonville Beach, Florida, Stati Uniti, 32250
    - Baptist Health Research Institute
  - Miami, Florida, Stati Uniti, 33173
    - Cardiovascular Research Center of South Florida
  - Miami, Florida, Stati Uniti, 33155
    - Gad Research Center
  - Ocala, Florida, Stati Uniti, 34471
    - Ocala Research Institute, Inc
  - Pensacola, Florida, Stati Uniti, 32501
    - Cardiology Consultants
  - Port Charlotte, Florida, Stati Uniti, 33952
    - Charlotte Heart Group Research Center
  - Sarasota, Florida, Stati Uniti, 34239
    - Cardiovascular Center of Sarasota
  - Sarasota, Florida, Stati Uniti, 34232
    - Intercoastal Medical Group
  - Winter Park, Florida, Stati Uniti, 32792
    - Florida Cardiology Group
  - Winter Park, Florida, Stati Uniti, 32792
    - The Florida Lipid Institute
- Georgia
  - Johns Creek, Georgia, Stati Uniti, 30024
    - NSC Research
- Idaho
  - Coeur d'Alene, Idaho, Stati Uniti, 83814
    - Kootenai Heart Clinics, LLC
- Illinois
  - Arlington Heights, Illinois, Stati Uniti, 60005
    - Northwest Heart Clinical Research LLC
- Indiana
  - Evansville, Indiana, Stati Uniti, 47713
    - Deaconess Clinic
  - Michigan City, Indiana, Stati Uniti, 46360
    - LaPorte County Institute for Clinical Research
- Iowa
  - Davenport, Iowa, Stati Uniti, 52801
    - Midwest Cardiovascular Research Foundation
  - Iowa City, Iowa, Stati Uniti, 52242
    - The University of Iowa College of Public Health
  - West Des Moines, Iowa, Stati Uniti, 50266
    - MercyOne Iowa Heart Center
- Kansas
  - Kansas City, Kansas, Stati Uniti, 66160-7601
    - The University of Kansas Medical Center
- Kentucky
  - Covington, Kentucky, Stati Uniti, 41011
    - Saint Elizabeth Covington
  - Lexington, Kentucky, Stati Uniti, 40503
    - The Research Group of Lexington LLC
- Louisiana
  - Alexandria, Louisiana, Stati Uniti, 71301
    - Alexandria Cardiology Clinic
  - Bossier City, Louisiana, Stati Uniti, 71111
    - Grace Research Llc
  - Eunice, Louisiana, Stati Uniti, 70535
    - Horizon Research Group of Opelousas LLC
  - Hammond, Louisiana, Stati Uniti, 70403
    - Louisiana Heart Center
  - Natchitoches, Louisiana, Stati Uniti, 71457
    - Barnum Medical Research
  - Shreveport, Louisiana, Stati Uniti, 71105
    - Grace Research Llc
  - Slidell, Louisiana, Stati Uniti, 70458
    - Louisiana Heart Center
- Maine
  - Bangor, Maine, Stati Uniti, 04401
    - Northern Light Eastern Maine Medical Center
  - Biddeford, Maine, Stati Uniti, 04005
    - Southern Maine Health Care
- Maryland
  - Baltimore, Maryland, Stati Uniti, 21229
    - Maryland Cardiovascular Specialists
  - Beltsville, Maryland, Stati Uniti, 20705
    - Metropolitan Cardiovascular Consultants LLC
  - Salisbury, Maryland, Stati Uniti, 21804
    - TidalHealth Peninsula Regional, Inc
- Massachusetts
  - Boston, Massachusetts, Stati Uniti, 02215
    - Brigham and Womens Hospital
  - Framingham, Massachusetts, Stati Uniti, 01701
    - Charles River Medical Associates
  - Great Barrington, Massachusetts, Stati Uniti, 01230
    - East Mountain Medical Associates, PC
  - Springfield, Massachusetts, Stati Uniti, 01199
    - Baystate Health Center
- Michigan
  - Flint, Michigan, Stati Uniti, 48504
    - Ahmed Arif Medical Research Center LLC
  - Grand Rapids, Michigan, Stati Uniti, 49546
    - Healthy Heart Cardiology
  - Jackson, Michigan, Stati Uniti, 49201
    - Rajendra H Mehta, MD, PC
  - Traverse City, Michigan, Stati Uniti, 49684
    - Munson Medical Center
- Minnesota
  - Duluth, Minnesota, Stati Uniti, 55805
    - Saint Marys Medical Center
  - Minneapolis, Minnesota, Stati Uniti, 55407
    - Minneapolis Heart Institute Foundation
  - Saint Cloud, Minnesota, Stati Uniti, 56303
    - Saint Cloud Hospital
  - Saint Paul, Minnesota, Stati Uniti, 55102
    - HealthEast Medical Research Institute
- Missouri
  - Kansas City, Missouri, Stati Uniti, 64128
    - Kansas City Veterans Affairs Medical Center
  - St Louis, Missouri, Stati Uniti, 63141
    - Mercy Research
- Montana
  - Great Falls, Montana, Stati Uniti, 59405
    - Great Falls Clinic LLP
- Nebraska
  - Lincoln, Nebraska, Stati Uniti, 68506
    - Bryan Heart
  - Omaha, Nebraska, Stati Uniti, 68105
    - Nebraska Western Iowa Health Care System
- Nevada
  - Las Vegas, Nevada, Stati Uniti, 89128
    - Palm Research Center Inc
- New Jersey
  - Voorhees Township, New Jersey, Stati Uniti, 08043
    - Virtua Health, Inc.
- New York
  - Brooklyn, New York, Stati Uniti, 11206
    - Healthwise Medical Associates
  - Cheektowaga, New York, Stati Uniti, 14227
    - Trinity Medical Western New York, PC
  - Kingston, New York, Stati Uniti, 12401
    - WMCHealth Heart and Vascular Institute Kingston Division of Cardiology
  - Manhasset, New York, Stati Uniti, 11030
    - Northwell Health Physician Partners Cardiology
  - New Hyde Park, New York, Stati Uniti, 11042
    - North Shore Diabetes and Endocrine Associates
  - New York, New York, Stati Uniti, 10022
    - Northwell Health Lenox Hill Heart and Vascular
  - Poughkeepsie, New York, Stati Uniti, 12601
    - Hudson Valley Cardiovascular Physicians PC
  - Saratoga Springs, New York, Stati Uniti, 12866
    - Saratoga Clinical Research, LLC
  - Southampton, New York, Stati Uniti, 11968
    - Division of Cardiovascular Research at Peconic Bay Medical Center
- North Carolina
  - Asheville, North Carolina, Stati Uniti, 28803
    - Asheville Cardiology Associates
  - Chapel Hill, North Carolina, Stati Uniti, 27599
    - University of North Carolina at Chapel Hill
  - Charlotte, North Carolina, Stati Uniti, 28204
    - Novant Health Heart and Vascular Institute
  - Greensboro, North Carolina, Stati Uniti, 27401
    - Moses H Cone Memorial Hospital
  - Mooresville, North Carolina, Stati Uniti, 28117
    - Crossroads Clinical Research Inc
  - Rocky Mount, North Carolina, Stati Uniti, 27804
    - Piedmont Medical Group Research of Rocky Mount
  - Salisbury, North Carolina, Stati Uniti, 28144
    - PMG Research of Salisbury
  - Winston-Salem, North Carolina, Stati Uniti, 27157
    - Wake Forest University Health Sciences
  - Winston-Salem, North Carolina, Stati Uniti, 27103
    - Novant Health Forsyth Medical Center
- North Dakota
  - Fargo, North Dakota, Stati Uniti, 58104
    - Lillestol Research LLC
- Ohio
  - Cincinnati, Ohio, Stati Uniti, 45219
    - The Christ Hospital
  - Cleveland, Ohio, Stati Uniti, 44106
    - University Hospitals Cleveland Medical Center
  - Elyria, Ohio, Stati Uniti, 44035
    - North Ohio Heart Center
  - Marion, Ohio, Stati Uniti, 43302
    - Sanjay Vora Research LLC
  - Sandusky, Ohio, Stati Uniti, 44870
    - North Ohio Heart Center-Sandusky
  - Springfield, Ohio, Stati Uniti, 45504
    - Heart House Research Foundation
- Oklahoma
  - Norman, Oklahoma, Stati Uniti, 73069
    - Intend Research
  - Tulsa, Oklahoma, Stati Uniti, 74133
    - Oklahoma Heart Institute
- Oregon
  - Portland, Oregon, Stati Uniti, 97239
    - Oregon Health and Science University
- Pennsylvania
  - Camp Hill, Pennsylvania, Stati Uniti, 17011
    - Capital Area Research LLC
  - Camp Hill, Pennsylvania, Stati Uniti, 17011
    - Geisinger Holy Spirit
  - Doylestown, Pennsylvania, Stati Uniti, 18901
    - Doylestown Health Cardiology
  - Jersey Shore, Pennsylvania, Stati Uniti, 17740
    - Lycoming Internal Medicine Inc
  - Philadelphia, Pennsylvania, Stati Uniti, 19104
    - Perelman Center for Advanced Medicine
  - Philadelphia, Pennsylvania, Stati Uniti, 19107
    - Cardiology Consultants of Philadelphia CCP
  - Pittsburgh, Pennsylvania, Stati Uniti, 15213
    - University of Pittsburgh Medical Center
- Rhode Island
  - Providence, Rhode Island, Stati Uniti, 02906
    - Miriam Hospital
- South Carolina
  - Charleston, South Carolina, Stati Uniti, 29412
    - Pharmacorp Clinical Trials Inc
  - Fort Mill, South Carolina, Stati Uniti, 29707
    - Piedmont Research Partners
  - Greenville, South Carolina, Stati Uniti, 29607
    - Tribe Clinical Research LLC Dba Mountain View Clinical Research
  - Little River, South Carolina, Stati Uniti, 29566
    - Main Street Physicians Care Waterway
  - Murrells Inlet, South Carolina, Stati Uniti, 29576
    - The Diabetes Center
  - Summerville, South Carolina, Stati Uniti, 29485
    - Palmetto Clinical Research
- South Dakota
  - Rapid City, South Dakota, Stati Uniti, 57701
    - Monument Health Clinical Research
- Tennessee
  - Oak Ridge, Tennessee, Stati Uniti, 37830
    - Parkway Cardiology Associates
- Texas
  - Dallas, Texas, Stati Uniti, 75235
    - Southwest Family Medicine Associates
  - Dallas, Texas, Stati Uniti, 75226
    - Soltero Cardiovascular Research Center
  - Kingwood, Texas, Stati Uniti, 77339
    - Texas Cardiology Associates of Houston
  - Kingwood, Texas, Stati Uniti, 77339
    - Humble Cardiology Associates
  - Lufkin, Texas, Stati Uniti, 75904
    - Texas Institute for Kidney and Endocrine Disorders
  - McKinney, Texas, Stati Uniti, 75071
    - Texas Institute of Cardiology
  - Mesquite, Texas, Stati Uniti, 75149
    - Southern Endocrinology Associates PA
  - Odessa, Texas, Stati Uniti, 79761
    - Permian Research Foundation
  - San Antonio, Texas, Stati Uniti, 78201
    - South Texas Cardiovascular Consultants PLLC
  - San Antonio, Texas, Stati Uniti, 78229
    - Mercury Medical Conversions LTD
  - Tomball, Texas, Stati Uniti, 77375
    - Northwest Houston Heart Center
- Utah
  - Farmington, Utah, Stati Uniti, 84025
    - Alpine Research Organization
- Virginia
  - Suffolk, Virginia, Stati Uniti, 23435
    - Suffolk Multispecialty Research LLC
  - Winchester, Virginia, Stati Uniti, 22601
    - Selma Medical Associates
- Washington
  - Puyallup, Washington, Stati Uniti, 98372
    - MultiCare Institute for Research and Innovation
  - Tacoma, Washington, Stati Uniti, 98405
    - Universal Research Group LLC
- Wisconsin
  - Wausau, Wisconsin, Stati Uniti, 54401
    - Aspirus Research Institute
Svezia
- - Borås, Svezia, 501 82
    - Södra Älvsborgs Sjukhus
  - Falun, Svezia, 791 82
    - Falu Lasarett
  - Gothenburg, Svezia, 405 45
    - Carlanderska
  - Gothenburg, Svezia, 413 45
    - Sahlgrenska Universitetssjukhus
  - Helsingborg, Svezia, 252 20
    - PharmaSite Helsingborg
  - Härnösand, Svezia, 871 31
    - Obackakliniken i Harnosand
  - Jönköping, Svezia, 551 85
    - Länssjukhuset Ryhov
  - Karlstad, Svezia, 651 85
    - Centralsjukhuset Karlstad
  - Lidköping, Svezia, 531 85
    - Skaraborgs sjukhus Lidkoping
  - Lund, Svezia, 222 21
    - Clemenstorgets Hjartmottagning
  - Malmö, Svezia, 211 52
    - Pharmasite Malmo
  - Stockholm, Svezia, 117 27
    - Akardo MedSite
  - Umeå, Svezia, 901 85
    - Norrlands universitetssjukhus
  - Varberg, Svezia, 432 81
    - Hallands sjukhus Varberg
  - Östersund, Svezia, 831 83
    - Östersunds Sjukhus
Taiwan
- - Kaohsiung City, Taiwan, 83301
    - Kaohsiung Chang Gung Memorial Hospital
  - Kaohsiung City, Taiwan, 80756
    - Kaohsiung Medical University Chung-Ho Memorial Hospital
  - New Taipei City, Taiwan, 25160
    - MacKay Memorial Hospital Tamsui Branch
  - Taichung, Taiwan, 40705
    - Taichung Veterans General Hospital
  - Taichung, Taiwan, 40201
    - Chung Shan Medical University Hospital
  - Tainan, Taiwan, 70403
    - National Cheng Kung University Hospital
  - Taipei, Taiwan, 10002
    - National Taiwan University Hospital
  - Taipei, Taiwan, 11217
    - Taipei Veterans General Hospital
  - Taoyuan, Taiwan, 33305
    - Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation
- Hualien
  - Hualien City, Hualien, Taiwan, 97002
    - Hualien Tzu Chi Hospital
Ucraina
- - Ivano-Frankivsk, Ucraina, 76018
    - Ivano-Frankivsk Regional Clinical Cardiology Center of Ivano-Frankivsk Regional Council
  - Kharkiv, Ucraina, 61002
    - Communal Healthcare Institution Kharkiv City Clinical Hospital No27
  - Kharkiv, Ucraina, 61106
    - Medical and Sanitary Unit of Open Joint Stock Company Kharkiv Tractor Plant
  - Kharkiv, Ucraina, 61176
    - Communal Noncommercial enterprise "City Hospital #8" of Kharkiv City Council
  - Kyiv, Ucraina, 01023
    - Oleksandrivska Clinical Hospital of Kyiv
  - Kyiv, Ucraina, 02091
    - Kyiv City Clinical Hospital 1
  - Kyiv, Ucraina, 02232
    - Communal Noncommercial Institution Consultative and Diagnostic Center of Desnianskyi District of Kyi
  - Kyiv, Ucraina, 02660
    - Kyiv City Clinical Emergency Medical Care Hospital
  - Kyiv, Ucraina, 03151
    - National Scientific Center "M.D. Strazhesko Institute of Cardiology"
  - Kyiv, Ucraina, 03680
    - State Institution National Scientific Center Acad MD Strazhesko Institute of cardiology of NAMS Ukr
  - Kyiv, Ucraina, 03680
    - State Institution National Scientific Center Acad Strazhesko Institute of Cardiology
  - Kyiv, Ucraina, 04050
    - Medical Centre CONSILIUM Medical
  - Uzhhorod, Ucraina, 88014
    - Zakarpattia Oblast Clinical Center of Cardiology and Cardio Surgery
  - Vinnytsia, Ucraina, 21018
    - Vinnytsia M I Pyrogov Regional Clinical Hospital Vinnytsia M I Pyrogov National Medical University
  - Vinnytsia, Ucraina, 21001
    - Private Small Enterprise, Medical Center Pulse
  - Zaporizhzhia, Ucraina, 69035
    - Communal Non-commercial enterprise "City Hospital #6 "of Zaporizhzhia City Council
Ungheria
- - Baja, Ungheria, 6500
    - Lausmed Kft
  - Balatonfüred, Ungheria, 8230
    - Allami Szivkorhaz Balatonfured
  - Balatonkeresztúr, Ungheria, 8647
    - Balatonmariafurdo Kozseg Onkormanyzatanak Haziorvosi Rendeloje
  - Ballószög, Ungheria, 6035
    - Med-Edu Bt
  - Berettyóújfalu, Ungheria, 4100
    - Grof Tisza Istvan Korhaz
  - Budapest, Ungheria, 1036
    - Obudai Egeszsegugyi Centrum Kft
  - Budapest, Ungheria, 1204
    - Jahn Ferenc Del-pesti Korhaz es Rendelointezet
  - Budapest, Ungheria, 1145
    - Uzsoki Utcai Korhaz
  - Budapest, Ungheria, 1096
    - Gottsegen György Országos Kardiológiai Intézet
  - Budapest, Ungheria, 1106
    - Bajcsy-Zsilinszky Korhaz es Rendelointezet
  - Budapest, Ungheria, 1122
    - Semmelweis Egyetem
  - Budapest, Ungheria, 1134
    - Magyar Honvedseg Egeszsegugyi Kozpont
  - Budapest, Ungheria, 1023
    - Betegapolo Irgalmas Rend - Budai Irgalmasrendi Korhaz
  - Budapest, Ungheria, 1033
    - Clinexpert Kft
  - Budapest, Ungheria, 1085
    - Semmelweis Egyetem Varosmajori Sziv- es Ergyogyaszati Klinika
  - Budapest, Ungheria, 1148
    - Zugloi Egeszsegugyi Szolgalat
  - Békéscsaba, Ungheria, 5600
    - Dr Lakatos Ferenc Private Cardiology Practice
  - Debrecen, Ungheria, 4032
    - Debreceni Egyetem Klinikai Kozpont
  - Eger, Ungheria, 3300
    - Markhot Ferenc Oktatokorhaz és Rendelointezet
  - Gyula, Ungheria, 5700
    - Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaz
  - Gyöngyös, Ungheria, 3200
    - Bugat Pal Korhaz
  - Gyöngyös, Ungheria, 3200
    - Pharma4 Trial Kft
  - Gödöllő, Ungheria, 2100
    - Erzsebet Gondozohaz
  - Hatvan, Ungheria, 3000
    - BKS Research Kft
  - Kalocsa, Ungheria, 6300
    - Bacs-Kiskun Megyei Korhaz Szegedi Tudomanyegyetem Altalanos Orvostudomanyi Kar Oktato Korhaza
  - Komárom, Ungheria, 2921
    - Selye János Kórház
  - Miskolc, Ungheria, 3526
    - Borsod-Abauj-Zemplen Megyei Kozponti Korhaz es Egyetemi Oktatokorhaz
  - Miskolc, Ungheria, 3529
    - CRU Hungary Kft
  - Pécs, Ungheria, 7624
    - Pécsi Tudományegyetem Klinikai Központ
  - Sopron, Ungheria, 9400
    - Soproni Erzsebet Oktato Korhaz es Rehabilitacios Intezet
  - Szeged, Ungheria, 6725
    - Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont Altalanos Orvostudomanyi Kar
  - Szeged, Ungheria, 6725
    - Szegedi Tudomanyegyetem Szent Gyorgyi Albert Klinikai Kozpont Altalanos Orvostudomanyi Kar
  - Szekszárd, Ungheria, 7100
    - Tolna Megyei Balassa Janos Korhaz
  - Szentes, Ungheria, 6600
    - Csongrad Megyei Dr Bugyi Istvan Korhaz
  - Szolnok, Ungheria, 5004
    - Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rendelointezet
  - Székesfehérvár, Ungheria, 8000
    - Praxispont Belvarosi Maganegeszsegugyi Kozpont
  - Zalaegerszeg, Ungheria, 8900
    - Belvarosi Egeszseghaz Kft

Criteri di partecipazione

I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.

Criteri di ammissibilità

Età idonea allo studio

Da 46 anni a 75 anni (Adulto, Adulto più anziano)

Accetta volontari sani

Descrizione

Criterio di inclusione:

Età: Soggetti adulti ≥ 50 (uomini) o ≥ 55 (donne) a ˂ 80 anni di età (entrambi i sessi) e che soddisfano i criteri lipidici
Colesterolo delle lipoproteine a bassa densità (LDL-C) ≥ 90 mg/dL (≥ 2,3 mmol/L) o colesterolo delle lipoproteine non ad alta densità (non-HDL) ≥ 120 mg/dL (≥ 3,1 mmol/L) o apolipoproteina B ≥ 80 mg/dL (≥ 1,56 µmol/L)
Evidenza di almeno uno dei seguenti allo screening (senza precedente infarto del miocardio o ictus):
A. Malattia coronarica (CAD) significativa B. Malattia cerebrovascolare aterosclerotica significativa C. Malattia arteriosa periferica significativa D. Diabete mellito
Almeno 1 caratteristica ad alto rischio

Criteri di esclusione

IM o ictus prima della randomizzazione
Innesto di bypass dell'arteria coronaria (CABG) ˂ 3 mesi prima dello screening
Velocità di filtrazione glomerulare stimata (eGFR) ˂ 15 mL/min/1,73 mq
Tachicardia ventricolare incontrollata o ricorrente in assenza di un defibrillatore cardioverter impiantabile.
Fibrillazione atriale o flutter atriale non in terapia anticoagulante (antagonista della vitamina K, eparina, eparina a basso peso molecolare, fondaparinux o anticoagulante orale non antagonista della vitamina K)
Trigliceridi ≥ 500 mg/dL (5,7 mmol/L) misurati fino a 3 mesi prima dello screening. Devono essere utilizzati i risultati più recenti.
Ultima frazione di eiezione ventricolare sinistra misurata ˂ 30% o Classe funzionale III/IV della New York Heart Association (NYHA)
Rivascolarizzazione arteriosa programmata

Piano di studio

Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.

Come è strutturato lo studio?

Dettagli di progettazione

Scopo principale: Trattamento
Assegnazione: Randomizzato
Modello interventistico: Assegnazione parallela
Mascheramento: Quadruplicare

Numero di armi

Armi e interventi

Gruppo di partecipanti / Arm	Intervento / Trattamento
Comparatore placebo: Placebo I partecipanti riceveranno un'iniezione sottocutanea di placebo una volta ogni 2 settimane (Q2W).	Droga: Placebo Somministrato per via sottocutanea utilizzando una penna autoiniettore.
Sperimentale: Evolocumab 140 mg Q2W I partecipanti riceveranno 140 mg di evolocumab mediante iniezione sottocutanea Q2W.	Droga: Evolocumab Somministrato per via sottocutanea utilizzando una penna autoiniettore. Altri nomi: Repatha AMG 145

Cosa sta misurando lo studio?

Misure di risultato primarie

Misura del risultato	Misura Descrizione	Lasso di tempo
Number of Participants Who Experienced Coronary Heart Disease (CHD) Death, Myocardial Infarction (MI), or Ischemic Stroke, Whichever Occurred First Lasso di tempo: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months	All deaths and individual components were adjudicated by an independent external clinical events committee (CEC), using standardized definitions. The number of participants who experienced CHD death, MI, or ischemic stroke, whichever occurred first, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.	From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
Number of Participants Who Experienced CHD Death, MI, Ischemic Stroke, or Any Ischemia-driven Arterial Revascularization, Whichever Occurred First Lasso di tempo: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months	All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced CHD death, MI, ischemic stroke, or any ischemia-driven arterial revascularization, whichever occurred first, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.	From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months

Misure di risultato secondarie

Misura del risultato	Misura Descrizione	Lasso di tempo
Number of Participants Who Experienced MI, Ischemic Stroke, or Any Ischemia-driven Arterial Revascularization Lasso di tempo: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months	All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced MI, ischemic stroke, or any ischemia-driven arterial revascularization, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.	From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
Number of Participants Who Experienced CHD Death, MI, or Any Ischemia-driven Arterial Revascularization Lasso di tempo: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months	All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced CHD death, MI, or any ischemia-driven arterial revascularization, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.	From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
Number of Participants Who Experienced Cardiovascular Death, MI, or Ischemic Stroke Lasso di tempo: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months	All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced cardiovascular death, MI, or ischemic stroke, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.	From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
Number of Participants Who Experienced CHD Death or MI Lasso di tempo: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months	All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced CHD death or MI, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.	From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
Number of Participants Who Experienced MI Lasso di tempo: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months	All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced MI, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.	From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
Number of Participants Who Experienced Any Ischemia-driven Arterial Revascularization Lasso di tempo: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months	All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced ischemia-driven arterial revascularization, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.	From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
Number of Participants Who Experienced CHD Death Lasso di tempo: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months	All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced CHD death, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.	From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
Number of Participants Who Experienced Cardiovascular Death Lasso di tempo: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months	All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced cardiovascular death, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.	From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
Number of Participants Who Died Due to Any Cause Lasso di tempo: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months	All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who died due to any cause, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.	From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months
Number of Participants Who Experienced Ischemic Stroke Lasso di tempo: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months	All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced ischemic stroke, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.	From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months

Collaboratori e investigatori

Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.

Sponsor

Amgen

Investigatori

Direttore dello studio: MD, Amgen

Pubblicazioni e link utili

La persona responsabile dell'inserimento delle informazioni sullo studio fornisce volontariamente queste pubblicazioni. Questi possono riguardare qualsiasi cosa relativa allo studio.

Pubblicazioni generali

Collegamenti utili

AmgenTrials clinical trials website

Studiare le date dei record

Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.

Studia le date principali

Inizio studio (Effettivo)

11 giugno 2019

Completamento primario (Effettivo)

25 luglio 2025

Completamento dello studio (Effettivo)

25 luglio 2025

Date di iscrizione allo studio

Primo inviato

11 marzo 2019

Primo inviato che soddisfa i criteri di controllo qualità

11 marzo 2019

Primo Inserito (Effettivo)

13 marzo 2019

Aggiornamenti dei record di studio

Ultimo aggiornamento pubblicato (Effettivo)

25 giugno 2026

Ultimo aggiornamento inviato che soddisfa i criteri QC

1 giugno 2026

Ultimo verificato

1 giugno 2026

Maggiori informazioni

Termini relativi a questo studio

Parole chiave

Termini MeSH pertinenti aggiuntivi

Altri numeri di identificazione dello studio

20170625
2018-004565-14 (Numero EudraCT)
2023-503673-38-00 (Ctis)

Piano per i dati dei singoli partecipanti (IPD)

Hai intenzione di condividere i dati dei singoli partecipanti (IPD)?

SÌ

Descrizione del piano IPD

Dati dei singoli pazienti anonimizzati per le variabili necessarie per affrontare la domanda di ricerca specifica in una richiesta di condivisione dei dati approvata.

Periodo di condivisione IPD

Le richieste di condivisione dei dati relative a questo studio saranno prese in considerazione a partire da 18 mesi dopo la conclusione dello studio e se 1) il prodotto e l'indicazione hanno ottenuto l'autorizzazione all'immissione in commercio sia negli Stati Uniti che in Europa o 2) lo sviluppo clinico per il prodotto e/o l'indicazione viene interrotto e i dati non saranno presentati alle autorità di regolamentazione. Non esiste una data di fine per l'idoneità a inviare una richiesta di condivisione dei dati per questo studio.

Criteri di accesso alla condivisione IPD

I ricercatori qualificati possono presentare una richiesta contenente gli obiettivi della ricerca, il/i prodotto/i Amgen e lo/gli studio/studi Amgen nell'ambito, gli endpoint/i risultati di interesse, il piano di analisi statistica, i requisiti in materia di dati, il piano di pubblicazione e le qualifiche del/i ricercatore/i. In generale, Amgen non soddisfa le richieste esterne di dati dei singoli pazienti allo scopo di rivalutare i problemi di sicurezza ed efficacia già affrontati nell'etichettatura del prodotto. Le richieste vengono esaminate da un comitato di consulenti interni. In caso di mancata approvazione, un comitato di revisione indipendente sulla condivisione dei dati arbitrerà e prenderà la decisione finale. Dopo l'approvazione, le informazioni necessarie per affrontare la domanda di ricerca saranno fornite secondo i termini di un accordo di condivisione dei dati. Ciò può includere dati anonimizzati di singoli pazienti e/o documenti di supporto disponibili, contenenti frammenti di codice di analisi ove previsto nelle specifiche di analisi. Ulteriori dettagli sono disponibili al link sottostante.

Tipo di informazioni di supporto alla condivisione IPD

STUDIO_PROTOCOLLO
LINFA
ICF
RSI

Informazioni su farmaci e dispositivi, documenti di studio

Studia un prodotto farmaceutico regolamentato dalla FDA degli Stati Uniti

Sì

Studia un dispositivo regolamentato dalla FDA degli Stati Uniti

Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .

Effetto di Evolocumab in pazienti ad alto rischio cardiovascolare senza precedente infarto miocardico o ictus (VESALIUS-CV)

Uno studio multicentrico in doppio cieco, randomizzato, controllato con placebo per valutare l'impatto di Evolocumab sugli eventi cardiovascolari maggiori nei pazienti ad alto rischio cardiovascolare senza precedente infarto del miocardio o ictus

Panoramica dello studio

Stato

Condizioni

Intervento / Trattamento

Tipo di studio

Iscrizione (Effettivo)

Fase

Contatti e Sedi

Luoghi di studio

Criteri di partecipazione

Criteri di ammissibilità

Età idonea allo studio

Accetta volontari sani

Descrizione

Piano di studio

Come è strutturato lo studio?

Dettagli di progettazione

Numero di armi

Armi e interventi

Gruppo di partecipanti / Arm

Intervento / Trattamento

Cosa sta misurando lo studio?

Misure di risultato primarie

Misura del risultato

Misura Descrizione

Lasso di tempo

Misure di risultato secondarie

Misura del risultato

Misura Descrizione

Lasso di tempo

Collaboratori e investigatori

Sponsor

Investigatori

Pubblicazioni e link utili

Pubblicazioni generali

Collegamenti utili

Studiare le date dei record

Studia le date principali

Inizio studio (Effettivo)

Completamento primario (Effettivo)

Completamento dello studio (Effettivo)

Date di iscrizione allo studio

Primo inviato

Primo inviato che soddisfa i criteri di controllo qualità

Primo Inserito (Effettivo)

Aggiornamenti dei record di studio

Ultimo aggiornamento pubblicato (Effettivo)

Ultimo aggiornamento inviato che soddisfa i criteri QC

Ultimo verificato

Maggiori informazioni

Termini relativi a questo studio

Parole chiave

Termini MeSH pertinenti aggiuntivi

Altri numeri di identificazione dello studio

Piano per i dati dei singoli partecipanti (IPD)

Hai intenzione di condividere i dati dei singoli partecipanti (IPD)?

Descrizione del piano IPD

Periodo di condivisione IPD

Criteri di accesso alla condivisione IPD

Tipo di informazioni di supporto alla condivisione IPD

Informazioni su farmaci e dispositivi, documenti di studio

Studia un prodotto farmaceutico regolamentato dalla FDA degli Stati Uniti

Studia un dispositivo regolamentato dalla FDA degli Stati Uniti