Denne side blev automatisk oversat, og nøjagtigheden af ​​oversættelsen er ikke garanteret. Der henvises til engelsk version for en kildetekst.

SWOG S1827 (MAVERICK) test af, om brugen af ​​hjernescanninger alene i stedet for hjernescanninger plus forebyggende hjernestråling påvirker levetiden hos patienter med småcellet lungekræft

9. juni 2026 opdateret af: SWOG Cancer Research Network

MR-hjerneovervågning alene versus MR-overvågning og profylaktisk kraniel bestråling (PCI): Et randomiseret fase III-forsøg i småcellet lungekræft (MAVERICK)

Dette fase III-forsøg studerer magnetisk resonansbilleddannelse (MRI) overvågning og profylaktisk kraniel bestråling (PCI) for at se, hvor godt de virker sammenlignet med MR-overvågning alene ved behandling af patienter med småcellet lungekræft. MR-scanninger bruges til at overvåge den mulige spredning af kræften med en MR-maskine over tid. PCI er strålebehandling, der leveres til hjernen i håb om at forhindre spredning af kræft ind i hjernen. Brugen af ​​hjerne-MRI alene kan reducere bivirkninger ved at modtage PCI og forlænge patienternes levetid. Overvågning med MR-scanninger alene (udsætte stråling indtil den faktiske spredning af kræften) kan være mindst lige så god som kombinationen af ​​PCI med MR-scanninger.

Studieoversigt

Status

Aktiv, ikke rekrutterende

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

PRIMÆR MÅL:

I. At evaluere, om samlet overlevelse (OS) med magnetisk resonansbilleddannelse (MRI) overvågning alene ikke er ringere end MR overvågning kombineret med profylaktisk kraniel bestråling (PCI) til behandling af småcellet lungekræft (SCLC).

SEKUNDÆRE MÅL:

I. At sammenligne cognitive failure free survival (CFFS) rate op til 12 måneder efter randomisering mellem armene.

II. At sammenligne hjernemetastasefri overlevelse mellem armene. III. At sammenligne OS mellem armene inden for undergrupperne af patienter med begrænset stadie og omfattende stadie sygdom.

IV. At sammenligne kognitive fejlfri overlevelse (CFFS) rater på vurderingstidspunkterne mellem armene.

V. At sammenligne den kumulative forekomst af kognitiv svigt med død som en konkurrerende risiko mellem armene.

VI. At sammenligne hyppigheden og sværhedsgraden af ​​toksiciteter mellem de to arme.

YDERLIGERE MÅL:

I. At indsamle blod til bankvirksomhed.

OVERSIGT: Patienterne randomiseres til 1 af 2 arme.

ARM I: Patienter gennemgår konventionel eller hippocampus undgåelse PCI over 20 minutter 5 dage om ugen i 2 uger. Patienter gennemgår også MR-scanning efter 3, 6, 9, 12, 18 og 24 måneder.

ARM II: Patienter gennemgår MR-scanning efter 3, 6, 9, 12, 18 og 24 måneder.

Undersøgelsestype

Interventionel

Tilmelding (Anslået)

668

Fase

  • Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Canada
    • British Columbia
      • Victoria, British Columbia, Canada, V8R 6V5
        • BCCA-Vancouver Island Cancer Centre
    • Manitoba
      • Winnipeg, Manitoba, Canada, R3E 0V9
        • CancerCare Manitoba
    • New Brunswick
      • Saint John, New Brunswick, Canada, E2L 4L2
        • Atlantic Health Sciences Corporation-Saint John Regional Hospital
    • Newfoundland and Labrador
      • St. John's, Newfoundland and Labrador, Canada, A1B 3V6
        • Doctor H. Bliss Murphy Cancer Centre
    • Ontario
      • Hamilton, Ontario, Canada, L8V 5C2
        • Juravinski Cancer Centre at Hamilton Health Sciences
      • Oshawa, Ontario, Canada, L1G 2B9
        • Lakeridge Health Oshawa
      • Toronto, Ontario, Canada, M5G 2M9
        • University Health Network-Princess Margaret Hospital
      • Toronto, Ontario, Canada, M4N 3M5
        • Odette Cancer Centre- Sunnybrook Health Sciences Centre
    • Quebec
      • Montreal, Quebec, Canada, H3H 2R9
        • The Research Institute of the McGill University Health Centre (MUHC)
      • Québec, Quebec, Canada, G1R 2J6
        • CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)
      • Sherbrooke, Quebec, Canada, J1H 5N4
        • Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
      • Trois-Rivières, Quebec, Canada, G8Z 3R9
        • Centre Hospitalier Regional de Trois-Rivieres
    • Saskatchewan
      • Regina, Saskatchewan, Canada, S4T 7T1
        • Allan Blair Cancer Centre
  • Chile
      • Independence, Chile, 8380455
        • Instituto Nacional del Cancer
  • Colombia
      • Bogotá, Colombia, 99999
        • Instituto Nacional de Cancerologia
  • Forenede Stater
    • Alabama
      • Birmingham, Alabama, Forenede Stater, 35233
        • University of Alabama at Birmingham Cancer Center
    • Alaska
      • Anchorage, Alaska, Forenede Stater, 99508
        • Katmai Oncology Group
      • Fairbanks, Alaska, Forenede Stater, 99701
        • Fairbanks Memorial Hospital
    • Arizona
      • Tucson, Arizona, Forenede Stater, 85704
        • University of Arizona Cancer Center-Orange Grove Campus
      • Tucson, Arizona, Forenede Stater, 85719
        • University of Arizona Cancer Center-North Campus
    • California
      • Corona, California, Forenede Stater, 92882
        • City of Hope Corona
      • Duarte, California, Forenede Stater, 91010
        • City of Hope Comprehensive Cancer Center
      • Loma Linda, California, Forenede Stater, 92357
        • Veterans Affairs Loma Linda Healthcare System
      • Long Beach, California, Forenede Stater, 90822
        • Tibor Rubin VA Medical Center
      • Los Angeles, California, Forenede Stater, 90033
        • USC / Norris Comprehensive Cancer Center
      • Los Angeles, California, Forenede Stater, 90033
        • Los Angeles General Medical Center
      • Sacramento, California, Forenede Stater, 95817
        • University of California Davis Comprehensive Cancer Center
      • San Francisco, California, Forenede Stater, 94121
        • Veterans Affairs Medical Center - San Francisco
      • South Pasadena, California, Forenede Stater, 91030
        • City of Hope South Pasadena
    • Colorado
      • Aurora, Colorado, Forenede Stater, 80045
        • Rocky Mountain Regional VA Medical Center
      • Aurora, Colorado, Forenede Stater, 80045
        • UCHealth University of Colorado Hospital
      • Colorado Springs, Colorado, Forenede Stater, 80909
        • UCHealth Memorial Hospital Central
      • Colorado Springs, Colorado, Forenede Stater, 80920
        • Memorial Hospital North
      • Fort Collins, Colorado, Forenede Stater, 80524
        • Poudre Valley Hospital
      • Fort Collins, Colorado, Forenede Stater, 80528
        • Cancer Care and Hematology-Fort Collins
      • Greeley, Colorado, Forenede Stater, 80631
        • UCHealth Greeley Hospital
      • Greeley, Colorado, Forenede Stater, 80631
        • Banner North Colorado Medical Center
      • Highlands Ranch, Colorado, Forenede Stater, 80129
        • UCHealth Highlands Ranch Hospital
      • Lakewood, Colorado, Forenede Stater, 80228
        • Saint Anthony Hospital
      • Loveland, Colorado, Forenede Stater, 80538
        • Medical Center of the Rockies
      • Loveland, Colorado, Forenede Stater, 80539
        • Banner McKee Medical Center
    • Connecticut
      • Greenwich, Connecticut, Forenede Stater, 06830
        • Smilow Cancer Hospital Care Center at Greenwich
      • Guilford, Connecticut, Forenede Stater, 06437
        • Smilow Cancer Hospital Care Center - Guilford
      • Hamden, Connecticut, Forenede Stater, 06518
        • Smilow Cancer Hospital-Hamden Care Center
      • New Haven, Connecticut, Forenede Stater, 06520
        • Yale University
      • Trumbull, Connecticut, Forenede Stater, 06611
        • Smilow Cancer Hospital Care Center-Trumbull
      • Waterford, Connecticut, Forenede Stater, 06385
        • Smilow Cancer Hospital Care Center - Waterford
      • West Haven, Connecticut, Forenede Stater, 06516
        • Veterans Affairs Connecticut Healthcare System-West Haven Campus
    • Delaware
      • Millville, Delaware, Forenede Stater, 19967
        • Beebe South Coastal Health Campus
      • Newark, Delaware, Forenede Stater, 19713
        • Helen F Graham Cancer Center
      • Newark, Delaware, Forenede Stater, 19713
        • Medical Oncology Hematology Consultants PA
      • Newark, Delaware, Forenede Stater, 19718
        • Christiana Care Health System-Christiana Hospital
      • Rehoboth Beach, Delaware, Forenede Stater, 19971
        • Beebe Health Campus
    • Florida
      • Atlantis, Florida, Forenede Stater, 33462
        • John Fitzgerald Kennedy Medical Center
      • Boca Raton, Florida, Forenede Stater, 33486
        • Boca Raton Regional Hospital
      • Clearwater, Florida, Forenede Stater, 33756
        • Morton Plant Hospital
      • Coral Gables, Florida, Forenede Stater, 33146
        • UM Sylvester Comprehensive Cancer Center at Coral Gables
      • Deerfield Beach, Florida, Forenede Stater, 33442
        • UM Sylvester Comprehensive Cancer Center at Deerfield Beach
      • Gainesville, Florida, Forenede Stater, 32610
        • University of Florida Health Science Center - Gainesville
      • Miami, Florida, Forenede Stater, 33136
        • University of Miami Miller School of Medicine-Sylvester Cancer Center
      • Tampa, Florida, Forenede Stater, 33612
        • Moffitt Cancer Center
    • Georgia
      • Alpharetta, Georgia, Forenede Stater, 30005
        • Northside Hospital-Alpharetta
      • Atlanta, Georgia, Forenede Stater, 30322
        • Emory University Hospital/Winship Cancer Institute
      • Atlanta, Georgia, Forenede Stater, 30342
        • Northside Hospital
      • Augusta, Georgia, Forenede Stater, 30912
        • Augusta University Medical Center
      • Canton, Georgia, Forenede Stater, 30115
        • Northside Hospital-Cherokee
      • Columbus, Georgia, Forenede Stater, 31904
        • John B Amos Cancer Center
      • Cumming, Georgia, Forenede Stater, 30041
        • Northside Hospital-Forsyth
      • Decatur, Georgia, Forenede Stater, 30033
        • Atlanta VA Medical Center
      • Newnan, Georgia, Forenede Stater, 30265
        • CTCA at Southeastern Regional Medical Center
      • Savannah, Georgia, Forenede Stater, 31405
        • Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
    • Hawaii
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Queen's Medical Center
      • Honolulu, Hawaii, Forenede Stater, 96817
        • The Cancer Center of Hawaii-Liliha
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Hawaii Cancer Care Inc - Waterfront Plaza
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Queen's Cancer Cenrer - POB I
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Straub Clinic and Hospital
      • Honolulu, Hawaii, Forenede Stater, 96813
        • University of Hawaii Cancer Center
      • Honolulu, Hawaii, Forenede Stater, 96817
        • Kuakini Medical Center
      • Honolulu, Hawaii, Forenede Stater, 96817
        • Queen's Cancer Center - Kuakini
      • ‘Aiea, Hawaii, Forenede Stater, 96701
        • Hawaii Cancer Care - Westridge
      • ‘Aiea, Hawaii, Forenede Stater, 96701
        • Pali Momi Medical Center
      • ‘Aiea, Hawaii, Forenede Stater, 96701
        • The Cancer Center of Hawaii-Pali Momi
    • Idaho
      • Coeur d'Alene, Idaho, Forenede Stater, 83814
        • Kootenai Health - Coeur d'Alene
      • Post Falls, Idaho, Forenede Stater, 83854
        • Kootenai Clinic Cancer Services - Post Falls
    • Illinois
      • Alton, Illinois, Forenede Stater, 62002
        • Alton Memorial Hospital
      • Alton, Illinois, Forenede Stater, 62002
        • OSF Saint Anthony's Health Center
      • Barrington, Illinois, Forenede Stater, 60010
        • Advocate Good Shepherd Hospital
      • Centralia, Illinois, Forenede Stater, 62801
        • Centralia Oncology Clinic
      • Chicago, Illinois, Forenede Stater, 60611
        • Northwestern University
      • Chicago, Illinois, Forenede Stater, 60612
        • Rush University Medical Center
      • Chicago, Illinois, Forenede Stater, 60612
        • University of Illinois
      • Crystal Lake, Illinois, Forenede Stater, 60014
        • AMG Crystal Lake - Oncology
      • Danville, Illinois, Forenede Stater, 61832
        • Carle at The Riverfront
      • Decatur, Illinois, Forenede Stater, 62526
        • Decatur Memorial Hospital
      • Decatur, Illinois, Forenede Stater, 62526
        • Cancer Care Specialists of Illinois - Decatur
      • Downers Grove, Illinois, Forenede Stater, 60515
        • Advocate Good Samaritan Hospital
      • Effingham, Illinois, Forenede Stater, 62401
        • Crossroads Cancer Center
      • Effingham, Illinois, Forenede Stater, 62401
        • Carle Physician Group-Effingham
      • Hines, Illinois, Forenede Stater, 60141
        • Edward Hines Jr VA Hospital
      • Mattoon, Illinois, Forenede Stater, 61938
        • Carle Physician Group-Mattoon/Charleston
      • Maywood, Illinois, Forenede Stater, 60153
        • Loyola University Medical Center
      • O'Fallon, Illinois, Forenede Stater, 62269
        • Cancer Care Center of O'Fallon
      • O'Fallon, Illinois, Forenede Stater, 62269
        • HSHS Saint Elizabeth's Hospital
      • Oak Lawn, Illinois, Forenede Stater, 60453-2699
        • Advocate Christ Medical Center
      • Park Ridge, Illinois, Forenede Stater, 60068
        • Advocate Lutheran General Hospital
      • Peoria, Illinois, Forenede Stater, 61636
        • Methodist Medical Center of Illinois
      • Peoria, Illinois, Forenede Stater, 61637
        • OSF Saint Francis Medical Center
      • Rockford, Illinois, Forenede Stater, 61114
        • UW Health Carbone Cancer Center Rockford
      • Shiloh, Illinois, Forenede Stater, 62269
        • Memorial Hospital East
      • Springfield, Illinois, Forenede Stater, 62702
        • Southern Illinois University School of Medicine
      • Springfield, Illinois, Forenede Stater, 62702
        • Springfield Clinic
      • Springfield, Illinois, Forenede Stater, 62781
        • Springfield Memorial Hospital
      • Urbana, Illinois, Forenede Stater, 61801
        • Carle Cancer Center
    • Indiana
      • Avon, Indiana, Forenede Stater, 46123
        • IU Health West Hospital
      • Carmel, Indiana, Forenede Stater, 46032
        • IU Health North Hospital
      • Crown Point, Indiana, Forenede Stater, 46307
        • Northwest Cancer Center - Main Campus
      • Dyer, Indiana, Forenede Stater, 46311
        • Northwest Oncology LLC
      • Hobart, Indiana, Forenede Stater, 46342
        • Northwest Cancer Center - Hobart
      • Hobart, Indiana, Forenede Stater, 46342
        • Saint Mary Medical Center
      • Indianapolis, Indiana, Forenede Stater, 46202
        • Indiana University/Melvin and Bren Simon Cancer Center
      • Indianapolis, Indiana, Forenede Stater, 46202
        • IU Health Methodist Hospital
      • Munster, Indiana, Forenede Stater, 46321
        • The Community Hospital
      • Munster, Indiana, Forenede Stater, 46321
        • Women's Diagnostic Center - Munster
      • Valparaiso, Indiana, Forenede Stater, 46383
        • Northwest Cancer Center - Valparaiso
    • Iowa
      • Ames, Iowa, Forenede Stater, 50010
        • McFarland Clinic - Ames
      • Cedar Rapids, Iowa, Forenede Stater, 52403
        • Mercy Hospital
      • Cedar Rapids, Iowa, Forenede Stater, 52403
        • Oncology Associates at Mercy Medical Center
      • Clive, Iowa, Forenede Stater, 50325
        • Mercy Cancer Center-West Lakes
      • Clive, Iowa, Forenede Stater, 50325
        • UI Health Care Mission Cancer and Blood - West Des Moines Clinic
      • Creston, Iowa, Forenede Stater, 50801
        • Greater Regional Medical Center
      • Des Moines, Iowa, Forenede Stater, 50309
        • Iowa Methodist Medical Center
      • Des Moines, Iowa, Forenede Stater, 50314
        • Mercy Medical Center - Des Moines
      • Des Moines, Iowa, Forenede Stater, 50314
        • Broadlawns Medical Center
      • Des Moines, Iowa, Forenede Stater, 50316
        • Iowa Lutheran Hospital
      • Des Moines, Iowa, Forenede Stater, 50309
        • UI Health Care Mission Cancer and Blood - Des Moines Clinic
      • Des Moines, Iowa, Forenede Stater, 50314
        • UI Health Care Mission Cancer and Blood - Laurel Clinic
      • West Des Moines, Iowa, Forenede Stater, 50266-7700
        • Methodist West Hospital
      • West Des Moines, Iowa, Forenede Stater, 50266
        • Mercy Medical Center-West Lakes
    • Kansas
      • Kansas City, Kansas, Forenede Stater, 66160
        • University of Kansas Cancer Center
      • Lawrence, Kansas, Forenede Stater, 66044
        • Lawrence Memorial Hospital
      • Overland Park, Kansas, Forenede Stater, 66210
        • University of Kansas Cancer Center-Overland Park
      • Salina, Kansas, Forenede Stater, 67401
        • Salina Regional Health Center
      • Topeka, Kansas, Forenede Stater, 66606
        • University of Kansas Health System Saint Francis Campus
      • Westwood, Kansas, Forenede Stater, 66205
        • University of Kansas Hospital-Westwood Cancer Center
      • Wichita, Kansas, Forenede Stater, 67214
        • Ascension Via Christi Hospitals Wichita
      • Wichita, Kansas, Forenede Stater, 67214
        • Wesley Medical Center
    • Kentucky
      • Edgewood, Kentucky, Forenede Stater, 41017
        • Saint Elizabeth Healthcare Edgewood
      • Fort Thomas, Kentucky, Forenede Stater, 41075
        • Saint Elizabeth Healthcare Fort Thomas
      • Lexington, Kentucky, Forenede Stater, 40536
        • University of Kentucky/Markey Cancer Center
      • Louisville, Kentucky, Forenede Stater, 40202
        • The James Graham Brown Cancer Center at University of Louisville
      • Louisville, Kentucky, Forenede Stater, 40245
        • UofL Health Medical Center Northeast
    • Louisiana
      • Metairie, Louisiana, Forenede Stater, 70006
        • East Jefferson General Hospital
      • New Orleans, Louisiana, Forenede Stater, 70112
        • University Medical Center New Orleans
      • New Orleans, Louisiana, Forenede Stater, 70112
        • Louisiana State University Health Science Center
    • Maine
      • Bath, Maine, Forenede Stater, 04530
        • MaineHealth Coastal Cancer Treatment Center
      • Brewer, Maine, Forenede Stater, 04412
        • Lafayette Family Cancer Center-EMMC
      • Portland, Maine, Forenede Stater, 04102
        • MaineHealth Maine Medical Center - Portland
      • Sanford, Maine, Forenede Stater, 04073
        • MaineHealth Cancer Care Center of York County
      • Scarborough, Maine, Forenede Stater, 04074
        • MaineHealth Maine Medical Center- Scarborough
    • Maryland
      • Annapolis, Maryland, Forenede Stater, 21401
        • Luminis Health Anne Arundel Medical Center
      • Baltimore, Maryland, Forenede Stater, 21215
        • Sinai Hospital of Baltimore
      • Baltimore, Maryland, Forenede Stater, 21201
        • University of Maryland/Greenebaum Cancer Center
      • Baltimore, Maryland, Forenede Stater, 21201
        • Veterans Administration Medical Center-Baltimore
      • Bel Air, Maryland, Forenede Stater, 21014
        • UM Upper Chesapeake Medical Center
      • Columbia, Maryland, Forenede Stater, 21044
        • Central Maryland Radiation Oncology in Howard County
      • Easton, Maryland, Forenede Stater, 21601
        • University of Maryland Shore Medical Center at Easton
      • Glen Burnie, Maryland, Forenede Stater, 21061
        • UM Baltimore Washington Medical Center/Tate Cancer Center
      • Ocean Pines, Maryland, Forenede Stater, 21811
        • TidalHealth Richard A Henson Cancer Institute
      • Salisbury, Maryland, Forenede Stater, 21801
        • TidalHealth Peninsula Regional
      • Westminster, Maryland, Forenede Stater, 21157
        • William E Kahlert Regional Cancer Center/Sinai Hospital
    • Massachusetts
      • Boston, Massachusetts, Forenede Stater, 02215
        • Dana-Farber Cancer Institute
      • Boston, Massachusetts, Forenede Stater, 02115
        • Brigham and Women's Hospital
      • Boston, Massachusetts, Forenede Stater, 02118
        • Boston Medical Center
      • Burlington, Massachusetts, Forenede Stater, 01805
        • Lahey Hospital and Medical Center
      • Milford, Massachusetts, Forenede Stater, 01757
        • Dana-Farber/Brigham and Women's Cancer Center at Milford Regional
      • Plymouth, Massachusetts, Forenede Stater, 02360
        • Beth Israel Deaconess Hospital-Plymouth
      • South Weymouth, Massachusetts, Forenede Stater, 02190
        • Dana-Farber/Brigham and Women's Cancer Center at South Shore
    • Michigan
      • Ann Arbor, Michigan, Forenede Stater, 48106
        • Trinity Health Saint Joseph Mercy Hospital Ann Arbor
      • Brighton, Michigan, Forenede Stater, 48114
        • Trinity Health IHA Medical Group Hematology Oncology - Brighton
      • Brighton, Michigan, Forenede Stater, 48114
        • Trinity Health Medical Center - Brighton
      • Brownstown, Michigan, Forenede Stater, 48183
        • Henry Ford Cancer Institute-Downriver
      • Canton, Michigan, Forenede Stater, 48188
        • Trinity Health Medical Center - Canton
      • Chelsea, Michigan, Forenede Stater, 48118
        • Chelsea Hospital
      • Dearborn, Michigan, Forenede Stater, 48124
        • Corewell Health Dearborn Hospital
      • Detroit, Michigan, Forenede Stater, 48202
        • Henry Ford Hospital
      • Detroit, Michigan, Forenede Stater, 48236
        • Henry Ford Health Saint John Hospital
      • Farmington Hills, Michigan, Forenede Stater, 48336
        • Corewell Health Farmington Hills Hospital
      • Kalamazoo, Michigan, Forenede Stater, 49007
        • West Michigan Cancer Center
      • Livonia, Michigan, Forenede Stater, 48154
        • Trinity Health Saint Mary Mercy Livonia Hospital
      • Pontiac, Michigan, Forenede Stater, 48341
        • Trinity Health Saint Joseph Mercy Oakland Hospital
      • Pontiac, Michigan, Forenede Stater, 48341
        • Michigan Healthcare Professionals Pontiac
      • Royal Oak, Michigan, Forenede Stater, 48073
        • Corewell Health William Beaumont University Hospital
      • Saginaw, Michigan, Forenede Stater, 48604
        • Oncology Hematology Associates of Saginaw Valley PC
      • Saginaw, Michigan, Forenede Stater, 48601
        • MyMichigan Medical Center Saginaw
      • Tawas City, Michigan, Forenede Stater, 48764
        • MyMichigan Medical Center Tawas
      • Traverse City, Michigan, Forenede Stater, 49684
        • Munson Medical Center
      • Troy, Michigan, Forenede Stater, 48085
        • Corewell Health Beaumont Troy Hospital
      • Warren, Michigan, Forenede Stater, 48093
        • Henry Ford Health Warren Hospital
      • West Bloomfield, Michigan, Forenede Stater, 48322
        • Henry Ford West Bloomfield Hospital
      • West Branch, Michigan, Forenede Stater, 48661
        • Saint Mary's Oncology/Hematology Associates of West Branch
      • Ypsilanti, Michigan, Forenede Stater, 48197
        • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
    • Minnesota
      • Bemidji, Minnesota, Forenede Stater, 56601
        • Sanford Joe Lueken Cancer Center
      • Duluth, Minnesota, Forenede Stater, 55805
        • Miller-Dwan Hospital
      • Minneapolis, Minnesota, Forenede Stater, 55415
        • Hennepin County Medical Center
      • Robbinsdale, Minnesota, Forenede Stater, 55422
        • North Memorial Medical Health Center
      • Saint Cloud, Minnesota, Forenede Stater, 56303
        • Coborn Cancer Center at Saint Cloud Hospital
      • Shakopee, Minnesota, Forenede Stater, 55379
        • Saint Francis Regional Medical Center
    • Mississippi
      • Oxford, Mississippi, Forenede Stater, 38655
        • Baptist Memorial Hospital and Cancer Center-Oxford
      • Southhaven, Mississippi, Forenede Stater, 38671
        • Baptist Memorial Hospital and Cancer Center-Desoto
    • Missouri
      • Cape Girardeau, Missouri, Forenede Stater, 63703
        • Saint Francis Medical Center
      • City of Saint Peters, Missouri, Forenede Stater, 63376
        • Siteman Cancer Center at Saint Peters Hospital
      • Columbia, Missouri, Forenede Stater, 65212
        • MU Health - University Hospital/Ellis Fischel Cancer Center
      • Creve Coeur, Missouri, Forenede Stater, 63141
        • Siteman Cancer Center at West County Hospital
      • Farmington, Missouri, Forenede Stater, 63640
        • Parkland Health Center - Farmington
      • Jefferson City, Missouri, Forenede Stater, 65109
        • MU Health Care Goldschmidt Cancer Center
      • Joplin, Missouri, Forenede Stater, 64804
        • Freeman Health System
      • Kansas City, Missouri, Forenede Stater, 64154
        • University of Kansas Cancer Center - North
      • Lee's Summit, Missouri, Forenede Stater, 64064
        • University of Kansas Cancer Center - Lee's Summit
      • North Kansas City, Missouri, Forenede Stater, 64116
        • University of Kansas Cancer Center at North Kansas City Hospital
      • Rolla, Missouri, Forenede Stater, 65401
        • Phelps Health Delbert Day Cancer Institute
      • Sainte Genevieve, Missouri, Forenede Stater, 63670
        • Sainte Genevieve County Memorial Hospital
      • St Louis, Missouri, Forenede Stater, 63110
        • Washington University School of Medicine
      • St Louis, Missouri, Forenede Stater, 63129
        • Siteman Cancer Center-South County
      • St Louis, Missouri, Forenede Stater, 63136
        • Siteman Cancer Center at Christian Hospital
      • St Louis, Missouri, Forenede Stater, 63131
        • Missouri Baptist Medical Center
      • Sullivan, Missouri, Forenede Stater, 63080
        • Missouri Baptist Sullivan Hospital
      • Sunset Hills, Missouri, Forenede Stater, 63127
        • BJC Outpatient Center at Sunset Hills
    • Montana
      • Billings, Montana, Forenede Stater, 59101
        • Billings Clinic Cancer Center
      • Butte, Montana, Forenede Stater, 59701
        • Saint James Community Hospital and Cancer Treatment Center
      • Great Falls, Montana, Forenede Stater, 59405
        • Benefis Sletten Cancer Institute
      • Kalispell, Montana, Forenede Stater, 59901
        • Logan Health Medical Center
    • Nebraska
      • Lincoln, Nebraska, Forenede Stater, 68516
        • Cancer Partners of Nebraska
      • Omaha, Nebraska, Forenede Stater, 68114
        • Nebraska Methodist Hospital
      • Omaha, Nebraska, Forenede Stater, 68124
        • Alegent Health Bergan Mercy Medical Center
    • New Jersey
      • Elizabeth, New Jersey, Forenede Stater, 07207
        • Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus
      • Hamilton, New Jersey, Forenede Stater, 08690
        • The Cancer Institute of New Jersey Hamilton
      • Long Branch, New Jersey, Forenede Stater, 07740
        • Monmouth Medical Center
      • New Brunswick, New Jersey, Forenede Stater, 08903
        • Rutgers Cancer Institute of New Jersey
      • Pennington, New Jersey, Forenede Stater, 08534
        • Capital Health Medical Center-Hopewell
      • Pompton, New Jersey, Forenede Stater, 07444
        • Chilton Medical Center
      • Somerville, New Jersey, Forenede Stater, 08876
        • Robert Wood Johnson University Hospital Somerset
      • Summit, New Jersey, Forenede Stater, 07902
        • Overlook Hospital
      • Toms River, New Jersey, Forenede Stater, 08755
        • Community Medical Center
    • New Mexico
      • Albuquerque, New Mexico, Forenede Stater, 87109
        • Lovelace Radiation Oncology
      • Albuquerque, New Mexico, Forenede Stater, 87106
        • University of New Mexico Cancer Center
    • New York
      • Buffalo, New York, Forenede Stater, 14263
        • Roswell Park Cancer Institute
      • Camillus, New York, Forenede Stater, 13031
        • Hematology Oncology Associates of CNY at Camillus
      • Canandiaqua, New York, Forenede Stater, 14424
        • Sands Cancer Center
      • East Syracuse, New York, Forenede Stater, 13057
        • Hematology Oncology Associates of Central New York-East Syracuse
      • Glens Falls, New York, Forenede Stater, 12801
        • Glens Falls Hospital
      • New York, New York, Forenede Stater, 10032
        • NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
      • Rochester, New York, Forenede Stater, 14642
        • University of Rochester
      • Rochester, New York, Forenede Stater, 14620
        • Highland Hospital
      • Stony Brook, New York, Forenede Stater, 11794
        • Stony Brook University Medical Center
      • Syracuse, New York, Forenede Stater, 13210
        • State University of New York Upstate Medical University
      • The Bronx, New York, Forenede Stater, 10461
        • Montefiore Medical Center-Einstein Campus
      • The Bronx, New York, Forenede Stater, 10467
        • Montefiore Medical Center - Moses Campus
      • The Bronx, New York, Forenede Stater, 10461
        • Montefiore Medical Center-Weiler Hospital
      • Verona, New York, Forenede Stater, 13478
        • Upstate Cancer Center at Verona
    • North Carolina
      • Albemarle, North Carolina, Forenede Stater, 28002
        • Atrium Health Stanly/LCI-Albemarle
      • Charlotte, North Carolina, Forenede Stater, 28203
        • Carolinas Medical Center/Levine Cancer Institute
      • Charlotte, North Carolina, Forenede Stater, 28204
        • Novant Health Presbyterian Medical Center
      • Charlotte, North Carolina, Forenede Stater, 28210
        • Atrium Health Pineville/LCI-Pineville
      • Charlotte, North Carolina, Forenede Stater, 28262
        • Atrium Health University City/LCI-University
      • Concord, North Carolina, Forenede Stater, 28025
        • Atrium Health Cabarrus/LCI-Concord
      • Durham, North Carolina, Forenede Stater, 27705
        • Durham VA Medical Center
      • Forest City, North Carolina, Forenede Stater, 28043
        • Levine Cancer Institute - Rutherford
      • Gastonia, North Carolina, Forenede Stater, 28054
        • CaroMont Regional Medical Center
      • Huntersville, North Carolina, Forenede Stater, 28078
        • Novant Health Cancer Institute - Huntersville
      • Huntersville, North Carolina, Forenede Stater, 28078
        • Novant Health Presbyterian Medical Center Huntersville
      • Kernersville, North Carolina, Forenede Stater, 27284
        • Novant Health Cancer Institute - Kernersville
      • Lincolnton, North Carolina, Forenede Stater, 28092
        • CaroMont Health - Lincoln Cancer Center
      • Matthews, North Carolina, Forenede Stater, 28105
        • Matthews Radiation Oncology Center
      • Matthews, North Carolina, Forenede Stater, 28105
        • Novant Health Cancer Institute - Matthews
      • Monroe, North Carolina, Forenede Stater, 28112
        • Atrium Health Union/LCI-Union
      • Mooresville, North Carolina, Forenede Stater, 28117
        • Novant Health Cancer Institute - Mooresville
      • Mount Airy, North Carolina, Forenede Stater, 27030
        • Novant Health Cancer Institute - Mount Airy
      • New Bern, North Carolina, Forenede Stater, 28561
        • CarolinaEast Medical Center
      • North Wilkesboro, North Carolina, Forenede Stater, 28659
        • Novant Health Cancer Institute - Wilkesboro
      • Salisbury, North Carolina, Forenede Stater, 28144
        • Novant Health Cancer Institute - Rowan
      • Salisbury, North Carolina, Forenede Stater, 28144
        • Rowan Regional Medical Center
      • Shelby, North Carolina, Forenede Stater, 28150
        • Atrium Health Cleveland/LCI-Cleveland
      • Stateville, North Carolina, Forenede Stater, 28625
        • Novant Health Cancer Institute - Statesville
      • Thomasville, North Carolina, Forenede Stater, 27360
        • Novant Health Cancer Institute - Thomasville
      • Winston-Salem, North Carolina, Forenede Stater, 27103
        • Novant Health Forsyth Medical Center
    • North Dakota
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Sanford Bismarck Medical Center
      • Fargo, North Dakota, Forenede Stater, 58122
        • Sanford Roger Maris Cancer Center
      • Fargo, North Dakota, Forenede Stater, 58122
        • Sanford Broadway Medical Center
      • Grand Forks, North Dakota, Forenede Stater, 58201
        • Altru Cancer Center
    • Ohio
      • Akron, Ohio, Forenede Stater, 44307
        • Cleveland Clinic Akron General
      • Beachwood, Ohio, Forenede Stater, 44122
        • UHHS-Chagrin Highlands Medical Center
      • Canton, Ohio, Forenede Stater, 44708
        • Cleveland Clinic Mercy Hospital
      • Centerville, Ohio, Forenede Stater, 45459
        • Miami Valley Hospital South
      • Cincinnati, Ohio, Forenede Stater, 45219
        • University of Cincinnati Cancer Center-UC Medical Center
      • Cleveland, Ohio, Forenede Stater, 44106
        • Case Western Reserve University
      • Cleveland, Ohio, Forenede Stater, 44106
        • Louis Stokes Cleveland VA Medical Center
      • Columbus, Ohio, Forenede Stater, 43214
        • Riverside Methodist Hospital
      • Columbus, Ohio, Forenede Stater, 43210
        • Ohio State University Comprehensive Cancer Center
      • Columbus, Ohio, Forenede Stater, 43228
        • Doctors Hospital
      • Columbus, Ohio, Forenede Stater, 43215
        • Grant Medical Center
      • Dayton, Ohio, Forenede Stater, 45415
        • Miami Valley Hospital North
      • Dayton, Ohio, Forenede Stater, 45409
        • Premier Blood and Cancer Center
      • Delaware, Ohio, Forenede Stater, 43015
        • Delaware Health Center-Grady Cancer Center
      • Delaware, Ohio, Forenede Stater, 43015
        • Grady Memorial Hospital
      • Dublin, Ohio, Forenede Stater, 43016
        • Dublin Methodist Hospital
      • Franklin, Ohio, Forenede Stater, 45005-1066
        • Atrium Medical Center-Middletown Regional Hospital
      • Greenville, Ohio, Forenede Stater, 45331
        • Miami Valley Cancer Care and Infusion
      • Grove City, Ohio, Forenede Stater, 43123
        • Mount Carmel Grove City Hospital
      • Mansfield, Ohio, Forenede Stater, 44903
        • OhioHealth Mansfield Hospital
      • Marion, Ohio, Forenede Stater, 43302
        • OhioHealth Marion General Hospital
      • Mentor, Ohio, Forenede Stater, 44060
        • UH Seidman Cancer Center at Lake Health Mentor Campus
      • Middleburg Heights, Ohio, Forenede Stater, 44130
        • UH Seidman Cancer Center at Southwest General Hospital
      • Parma, Ohio, Forenede Stater, 44129
        • University Hospitals Parma Medical Center
      • Perrysburg, Ohio, Forenede Stater, 43551
        • Mercy Health - Perrysburg Hospital
      • Ravenna, Ohio, Forenede Stater, 44266
        • University Hospitals Portage Medical Center
      • Toledo, Ohio, Forenede Stater, 43623
        • Mercy Health - Saint Anne Hospital
      • Troy, Ohio, Forenede Stater, 45373
        • Upper Valley Medical Center
      • West Chester, Ohio, Forenede Stater, 45069
        • University of Cincinnati Cancer Center-West Chester
      • Westlake, Ohio, Forenede Stater, 44145
        • UH Seidman Cancer Center at Saint John Medical Center
      • Westlake, Ohio, Forenede Stater, 44145
        • UHHS-Westlake Medical Center
      • Zanesville, Ohio, Forenede Stater, 43701
        • Genesis Healthcare System Cancer Care Center
    • Oklahoma
      • Oklahoma City, Oklahoma, Forenede Stater, 73104
        • University of Oklahoma Health Sciences Center
    • Pennsylvania
      • Beaver, Pennsylvania, Forenede Stater, 15009
        • UPMC-Heritage Valley Health System Beaver
      • Bethlehem, Pennsylvania, Forenede Stater, 18017
        • Lehigh Valley Hospital - Muhlenberg
      • Broomall, Pennsylvania, Forenede Stater, 19008
        • Crozer-Keystone Regional Cancer Center at Broomall
      • Bryn Mawr, Pennsylvania, Forenede Stater, 19010
        • Bryn Mawr Hospital
      • Carlisle, Pennsylvania, Forenede Stater, 17015
        • Carlisle Regional Cancer Center
      • Chadds Ford, Pennsylvania, Forenede Stater, 19317
        • Christiana Care Health System-Concord Health Center
      • Chambersburg, Pennsylvania, Forenede Stater, 17201
        • Chambersburg Hospital
      • Danville, Pennsylvania, Forenede Stater, 17822
        • Geisinger Medical Center
      • East Norriton, Pennsylvania, Forenede Stater, 19401
        • Fox Chase Cancer Center - East Norriton Hospital Outpatient Center
      • East Stroudsburg, Pennsylvania, Forenede Stater, 18301
        • Pocono Medical Center
      • Ephrata, Pennsylvania, Forenede Stater, 17522
        • Ephrata Cancer Center
      • Erie, Pennsylvania, Forenede Stater, 16505
        • UPMC Hillman Cancer Center Erie
      • Farrell, Pennsylvania, Forenede Stater, 16121
        • UPMC Cancer Center at UPMC Horizon
      • Furlong, Pennsylvania, Forenede Stater, 18925
        • Fox Chase Cancer Center Buckingham
      • Gettysburg, Pennsylvania, Forenede Stater, 17325
        • Adams Cancer Center
      • Glen Mills, Pennsylvania, Forenede Stater, 19342
        • Crozer Regional Cancer Center at Brinton Lake
      • Greensburg, Pennsylvania, Forenede Stater, 15601
        • UPMC Cancer Centers - Arnold Palmer Pavilion
      • Harrisburg, Pennsylvania, Forenede Stater, 17109
        • UPMC Pinnacle Cancer Center/Community Osteopathic Campus
      • Johnstown, Pennsylvania, Forenede Stater, 15901
        • UPMC-Johnstown/John P. Murtha Regional Cancer Center
      • Lebanon, Pennsylvania, Forenede Stater, 17042
        • Sechler Family Cancer Center
      • Lewisburg, Pennsylvania, Forenede Stater, 17837
        • Geisinger Medical Oncology-Lewisburg
      • McKeesport, Pennsylvania, Forenede Stater, 15132
        • UPMC Cancer Center at UPMC McKeesport
      • Mechanicsburg, Pennsylvania, Forenede Stater, 17050
        • UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
      • Media, Pennsylvania, Forenede Stater, 19063
        • Riddle Memorial Hospital
      • Monroeville, Pennsylvania, Forenede Stater, 15146
        • UPMC Cancer Center - Monroeville
      • Moon Township, Pennsylvania, Forenede Stater, 15108
        • UPMC Hillman Cancer Center in Coraopolis
      • Paoli, Pennsylvania, Forenede Stater, 19301
        • Paoli Memorial Hospital
      • Philadelphia, Pennsylvania, Forenede Stater, 19111
        • Fox Chase Cancer Center
      • Philadelphia, Pennsylvania, Forenede Stater, 19140
        • Temple University Hospital
      • Pittsburgh, Pennsylvania, Forenede Stater, 15213
        • UPMC-Magee Womens Hospital
      • Pittsburgh, Pennsylvania, Forenede Stater, 15232
        • University of Pittsburgh Cancer Institute (UPCI)
      • Pittsburgh, Pennsylvania, Forenede Stater, 15232
        • UPMC-Shadyside Hospital
      • Pittsburgh, Pennsylvania, Forenede Stater, 15215
        • UPMC-Saint Margaret
      • Pittsburgh, Pennsylvania, Forenede Stater, 15237
        • UPMC-Passavant Hospital
      • Pittsburgh, Pennsylvania, Forenede Stater, 15243
        • UPMC-Saint Clair Hospital Cancer Center
      • Sayre, Pennsylvania, Forenede Stater, 18840
        • Guthrie Medical Group PC-Robert Packer Hospital
      • Seneca, Pennsylvania, Forenede Stater, 16346
        • UPMC Cancer Center at UPMC Northwest
      • Uniontown, Pennsylvania, Forenede Stater, 15401
        • UPMC Uniontown Hospital Radiation Oncology
      • Washington, Pennsylvania, Forenede Stater, 15301
        • UPMC Washington Hospital Radiation Oncology
      • West Reading, Pennsylvania, Forenede Stater, 19611
        • Reading Hospital
      • Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
        • Geisinger Wyoming Valley/Henry Cancer Center
      • Williamsport, Pennsylvania, Forenede Stater, 17701
        • UPMC Susquehanna
      • Williamsport, Pennsylvania, Forenede Stater, 17754
        • Divine Providence Hospital
      • Wynnewood, Pennsylvania, Forenede Stater, 19096
        • Lankenau Medical Center
      • York, Pennsylvania, Forenede Stater, 17403
        • WellSpan Health-York Cancer Center
      • York, Pennsylvania, Forenede Stater, 17408
        • UPMC Memorial
    • South Carolina
      • Bluffton, South Carolina, Forenede Stater, 29910
        • Saint Joseph's/Candler - Bluffton Campus
      • Greenville, South Carolina, Forenede Stater, 29607
        • Saint Francis Cancer Center
      • Greenville, South Carolina, Forenede Stater, 29601
        • Saint Francis Hospital
      • Greenwood, South Carolina, Forenede Stater, 29646
        • Self Regional Healthcare
      • Greer, South Carolina, Forenede Stater, 29651
        • Gibbs Cancer Center-Pelham
      • Hilton Head Island, South Carolina, Forenede Stater, 29926
        • The Radiation Oncology Center-Hilton Head/Bluffton
      • Rock Hill, South Carolina, Forenede Stater, 29732
        • Levine Cancer Institute-Rock Hill
      • Rock Hill, South Carolina, Forenede Stater, 29730
        • Rock Hill Radiation Therapy Center
      • Spartanburg, South Carolina, Forenede Stater, 29303
        • Spartanburg Medical Center
    • South Dakota
      • Pierre, South Dakota, Forenede Stater, 57501
        • Avera Cancer Institute at Pierre
      • Sioux Falls, South Dakota, Forenede Stater, 57105
        • Avera Cancer Institute
      • Sioux Falls, South Dakota, Forenede Stater, 57117-5134
        • Sanford USD Medical Center - Sioux Falls
      • Sioux Falls, South Dakota, Forenede Stater, 57104
        • Sanford Cancer Center Oncology Clinic
      • Yankton, South Dakota, Forenede Stater, 57078
        • Avera Cancer Institute at Yankton
    • Tennessee
      • Collierville, Tennessee, Forenede Stater, 38017
        • Baptist Memorial Hospital and Cancer Center-Collierville
      • Memphis, Tennessee, Forenede Stater, 38120
        • Baptist Memorial Hospital and Cancer Center-Memphis
    • Texas
      • Conroe, Texas, Forenede Stater, 77384
        • MD Anderson in The Woodlands
      • Houston, Texas, Forenede Stater, 77030
        • M D Anderson Cancer Center
      • Houston, Texas, Forenede Stater, 77030
        • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
      • Houston, Texas, Forenede Stater, 77030
        • Michael E DeBakey VA Medical Center
      • Houston, Texas, Forenede Stater, 77030
        • Ben Taub General Hospital
      • Houston, Texas, Forenede Stater, 77079
        • MD Anderson West Houston
      • League City, Texas, Forenede Stater, 77573
        • MD Anderson League City
      • San Antonio, Texas, Forenede Stater, 78229
        • Audie L Murphy VA Hospital
      • Sugar Land, Texas, Forenede Stater, 77478
        • MD Anderson in Sugar Land
    • Utah
      • Farmington, Utah, Forenede Stater, 84025
        • Farmington Health Center
      • Salt Lake City, Utah, Forenede Stater, 84112
        • Huntsman Cancer Institute/University of Utah
      • Salt Lake City, Utah, Forenede Stater, 84106
        • University of Utah Sugarhouse Health Center
    • Virginia
      • Fishersville, Virginia, Forenede Stater, 22939
        • Augusta Health Center for Cancer and Blood Disorders
      • Richmond, Virginia, Forenede Stater, 23235
        • VCU Massey Cancer Center at Stony Point
      • Richmond, Virginia, Forenede Stater, 23298
        • Virginia Commonwealth University/Massey Cancer Center
    • West Virginia
      • Morgantown, West Virginia, Forenede Stater, 26506
        • West Virginia University Healthcare
      • Parkersburg, West Virginia, Forenede Stater, 26101
        • Camden Clark Medical Center
    • Wisconsin
      • Antigo, Wisconsin, Forenede Stater, 54409
        • Langlade Hospital and Cancer Center
      • Appleton, Wisconsin, Forenede Stater, 54911
        • ThedaCare Regional Cancer Center
      • Appleton, Wisconsin, Forenede Stater, 54911
        • ThedaCare Regional Medical Center - Appleton
      • Ashland, Wisconsin, Forenede Stater, 54806
        • Northwest Wisconsin Cancer Center
      • Berlin, Wisconsin, Forenede Stater, 54923
        • ThedaCare Cancer Care - Berlin
      • Eau Claire, Wisconsin, Forenede Stater, 54701
        • Marshfield Medical Center-EC Cancer Center
      • Grafton, Wisconsin, Forenede Stater, 53024
        • Aurora Cancer Care-Grafton
      • Green Bay, Wisconsin, Forenede Stater, 54311
        • Aurora BayCare Medical Center
      • Kenosha, Wisconsin, Forenede Stater, 53142
        • Aurora Cancer Care-Kenosha South
      • La Crosse, Wisconsin, Forenede Stater, 54601
        • Gundersen Lutheran Medical Center
      • Ladysmith, Wisconsin, Forenede Stater, 54848
        • Marshfield Medical Center - Ladysmith
      • Marinette, Wisconsin, Forenede Stater, 54143
        • Aurora Bay Area Medical Group-Marinette
      • Marshfield, Wisconsin, Forenede Stater, 54449
        • Marshfield Medical Center-Marshfield
      • Menomonee Falls, Wisconsin, Forenede Stater, 53051
        • Froedtert Menomonee Falls Hospital
      • Milwaukee, Wisconsin, Forenede Stater, 53226
        • Medical College of Wisconsin
      • Milwaukee, Wisconsin, Forenede Stater, 53209
        • Aurora Cancer Care-Milwaukee
      • Milwaukee, Wisconsin, Forenede Stater, 53215
        • Aurora Saint Luke's Medical Center
      • Milwaukee, Wisconsin, Forenede Stater, 53233
        • Aurora Sinai Medical Center
      • Milwaukee, Wisconsin, Forenede Stater, 53295
        • Zablocki Veterans Administration Medical Center
      • Minocqua, Wisconsin, Forenede Stater, 54548
        • Marshfield Medical Center - Minocqua
      • Mukwonago, Wisconsin, Forenede Stater, 53149
        • ProHealth D N Greenwald Center
      • Neenah, Wisconsin, Forenede Stater, 54956
        • ThedaCare Regional Medical Center - Neenah
      • New London, Wisconsin, Forenede Stater, 54961
        • ThedaCare Cancer Care - New London
      • Oak Creek, Wisconsin, Forenede Stater, 53154
        • Drexel Town Square Health Center
      • Oconomowoc, Wisconsin, Forenede Stater, 53066
        • ProHealth Oconomowoc Memorial Hospital
      • Oshkosh, Wisconsin, Forenede Stater, 54904
        • Vince Lombardi Cancer Clinic - Oshkosh
      • Oshkosh, Wisconsin, Forenede Stater, 54904
        • ThedaCare Cancer Care - Oshkosh
      • Rhinelander, Wisconsin, Forenede Stater, 54501
        • Aspirus Cancer Care - James Beck Cancer Center
      • Rice Lake, Wisconsin, Forenede Stater, 54868
        • Marshfield Medical Center-Rice Lake
      • Shawano, Wisconsin, Forenede Stater, 54166
        • ThedaCare Cancer Care - Shawano
      • Sheboygan, Wisconsin, Forenede Stater, 53081
        • Vince Lombardi Cancer Clinic-Sheboygan
      • Stevens Point, Wisconsin, Forenede Stater, 54482
        • Marshfield Medical Center-River Region at Stevens Point
      • Stevens Point, Wisconsin, Forenede Stater, 54481
        • Aspirus Cancer Care - Stevens Point
      • Summit, Wisconsin, Forenede Stater, 53066
        • Aurora Medical Center in Summit
      • Two Rivers, Wisconsin, Forenede Stater, 54241
        • Vince Lombardi Cancer Clinic-Two Rivers
      • Waukesha, Wisconsin, Forenede Stater, 53188
        • UW Cancer Center at ProHealth Care
      • Waupaca, Wisconsin, Forenede Stater, 54981
        • ThedaCare Cancer Care - Waupaca
      • Wausau, Wisconsin, Forenede Stater, 54401
        • Aspirus Regional Cancer Center
      • West Allis, Wisconsin, Forenede Stater, 53227
        • Aurora West Allis Medical Center
      • West Bend, Wisconsin, Forenede Stater, 53095
        • Froedtert West Bend Hospital/Kraemer Cancer Center
      • Weston, Wisconsin, Forenede Stater, 54476
        • Marshfield Medical Center - Weston
      • Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
        • Aspirus Cancer Care - Wisconsin Rapids
  • Mexico
    • Tlalpan
      • Mexico City, Tlalpan, Mexico, 14080
        • Instituto Nacional De Cancerologia de Mexico
  • Saudi Arabien
      • Riyadh, Saudi Arabien, 11211
        • King Faisal Specialist Hospital and Research Centre
  • Sydkorea
    • Gyeonggi-do
      • Goyang-si, Gyeonggi-do, Sydkorea, 410-769
        • National Cancer Center-Korea

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Beskrivelse

Inklusionskriterier:

  • Patienten skal have en histologisk bekræftet diagnose af småcellet lungekræft (SCLC)
  • Patienten skal have foretaget en MR af hjernen inden for 28 dage før registrering, der ikke dokumenterer tegn på hjernemetastaser eller leptomeningeal sygdom. Patienten må heller ikke have en historie med hjernemetastaser eller leptomeningeal sygdom
  • Immunterapi samtidig med og/eller adjuverende til førstelinjebehandling er tilladt efter den behandlende læges skøn. Patienter med begrænset stadie (LS)-SCLC skal have gennemført platinbaseret kemoterapi og enten definitiv thoraxstrålebehandling (herunder stereotaktisk kropsstrålebehandling [SBRT] for tidligt stadie T1-2 N0 M0 sygdom, som ikke skal opereres) eller endelig kirurgisk resektion; thoraxbestråling ud over endelig kirurgisk resektion er tilladt efter den behandlende læges skøn, men er ikke påkrævet. Patienter med ekstensivt stadium (ES)-SCLC skal have gennemført platinbaseret kemoterapi enten med eller uden thoraxstrålebehandling efter den behandlende læges skøn
  • Alle bivirkninger fra tidligere behandling skal være løst til =< grad 2 (Common Terminology Criteria for Adverse Events [CTCAE] version 5.0) før randomisering
  • Patienten skal efter den behandlende investigator have haft respons på førstelinjebehandling og ingen tegn på progression. Systemisk billeddannelse (computertomografi [CT] eller positronemissionstomografi [PET]/CT inklusive bryst og abdomen) skal udføres inden for 28 dage før randomisering
  • Der må ikke være gået mere end 8 uger mellem dag 1 i den sidste kemoterapicyklus og randomisering
  • Patienten må ikke tidligere have modtaget strålebehandling til hjernen eller helhjernestrålebehandling. Patienter, der tidligere har gennemgået stereotaktisk strålekirurgi for godartede tumorer eller tilstande (f.eks. akustisk neurom, grad I meningeom, trigeminusneuralgi) kan overvejes fra sag til sag.
  • Patienten skal have Zubrod præstationsstatus på 0-2
  • Patienten må ikke have en kontraindikation til MR-billeddannelse, såsom implanterede metalanordninger eller fremmedlegemer
  • Patienten må ikke have en kontraindikation for administration af gadoliniumkontrast under MR-billeddannelse, såsom allergi eller utilstrækkelig nyrefunktion
  • Patienten må ikke have andre metastatiske maligniteter, der kræver aktuel aktiv behandling

  • Patienten må ikke have nogen alvorlige aktive komorbiditeter, defineret som følger:

    • Ustabil angina og/eller kongestiv hjertesvigt, der kræver indlæggelse inden for 6 måneder før randomisering
    • Transmuralt myokardieinfarkt inden for 6 måneder før randomisering
    • Akut bakteriel eller svampeinfektion, der kræver intravenøs antibiotika på tidspunktet for randomisering
    • Kronisk obstruktiv lungesygdom eksacerbation eller anden akut luftvejssygdom, der udelukker undersøgelsesterapi på tidspunktet for randomisering
    • Alvorlig leversygdom defineret som en diagnose af Child-Pugh klasse B eller C leversygdom

    • Human immundefektvirus (HIV) positiv med CD4-tal < 200 celler/mikroliter

      • Bemærk, at patienter, der er HIV-positive, er kvalificerede, forudsat at de er under behandling med højaktiv antiretroviral terapi (HAART) og har et CD4-tal >= 200 celler/mikroliter inden for 16 uger før randomisering
      • Bemærk også, at HIV-testning ikke er påkrævet for at være berettiget til denne protokol
  • Patienten må ikke være gravid på grund af føtale risici fra strålingseksponering. Mænd skal have accepteret at bruge en effektiv præventionsmetode under PCI og i seks måneder efter at have afsluttet PCI. Kvinder med reproduktionspotentiale skal have accepteret at bruge en effektiv præventionsmetode under PCI. En kvinde anses for at have "reproduktionspotentiale", hvis hun har haft menstruation på noget tidspunkt i de foregående 12 på hinanden følgende måneder. Ud over rutinepræventionsmetoder omfatter "effektiv prævention" også heteroseksuel cølibat og kirurgi beregnet til at forhindre graviditet (eller med en bivirkning af graviditetsforebyggelse) defineret som hysterektomi, bilateral ooforektomi eller bilateral tubal ligering. Men hvis en tidligere cølibatpatient på et tidspunkt vælger at blive heteroseksuelt aktiv i løbet af tidsperioden for brug af præventionsforanstaltninger, der er beskrevet i protokollen, er han/hun ansvarlig for at påbegynde præventionsforanstaltninger
  • Patienter, der taler og forstår engelsk eller fransk, skal acceptere at deltage i kognitiv funktionstest
  • Patienten skal tilbydes mulighed for at få prøver sendt til bank
  • Patienterne skal informeres om undersøgelsens karakter af denne undersøgelse og skal underskrive og give skriftligt informeret samtykke i overensstemmelse med institutionelle og føderale retningslinjer
  • Som en del af Oncology Patient Enrollment Network (OPEN) randomiseringsprocessen er den behandlende institution identitet er angivet for at sikre, at den aktuelle (inden for 365 dage) dato for institutionelle bedømmelsesudvalgs godkendelse af denne undersøgelse er blevet indtastet i systemet

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Behandling
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Ingen (Åben etiket)

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Aktiv komparator: Arm I (PCI, MRI)
Patienter gennemgår konventionel eller hippocampal undgåelse PCI over 20 minutter 5 dage om ugen i 2 uger. Patienter gennemgår også MR-scanning efter 3, 6, 9, 12, 18 og 24 måneder.
Procedure: MR scanning
Gennemgå MR
Andre navne:
  • MR
  • Magnetisk resonansbilledscanning
  • Medicinsk billeddannelse, magnetisk resonans / kernemagnetisk resonans
  • MR billeddannelse
  • MR-scanning
  • NMR billeddannelse
  • NMRI
  • Kernemagnetisk resonansbilleddannelse
Stråling: Profylaktisk kraniel bestråling
Gennemgå PCI
Andre navne:
  • PCI
Eksperimentel: Arm II (MRI)
Patienter gennemgår MR-scanning efter 3, 6, 9, 12, 18 og 24 måneder.
Procedure: MR scanning
Gennemgå MR
Andre navne:
  • MR
  • Magnetisk resonansbilledscanning
  • Medicinsk billeddannelse, magnetisk resonans / kernemagnetisk resonans
  • MR billeddannelse
  • MR-scanning
  • NMR billeddannelse
  • NMRI
  • Kernemagnetisk resonansbilleddannelse

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Samlet overlevelse (OS)
Tidsramme: Fra registreringsdatoen til datoen for dødsfald på grund af enhver årsag, vurderet op til 2 år efter randomisering
Vil evaluere OS med magnetisk resonansbilleddannelse (MRI) overvågning alene og MRI overvågning kombineret med profylaktisk kraniebestråling (PCI) til behandling af småcellet lungecancer (SCLC).
Fra registreringsdatoen til datoen for dødsfald på grund af enhver årsag, vurderet op til 2 år efter randomisering

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Kognitiv fejlfri overlevelse (CFFS)
Tidsramme: Baseline til første neurokognitiv svigt CF eller død på grund af enhver årsag, vurderet op til 12 måneder efter randomisering
Sammenligningen af ​​CFFS op til 12 måneder mellem armene vil blive udført ved hjælp af en 1-sidet 5 % niveau log-rank test.
Baseline til første neurokognitiv svigt CF eller død på grund af enhver årsag, vurderet op til 12 måneder efter randomisering
CFFS rate
Tidsramme: Baseline til første neurokognitiv svigt CF eller død på grund af enhver årsag, vurderet til 90, 180, 270, 360, 540 og 720 dage efter randomisering
Der vil være en sammenligning af CFFS-raterne mellem armene på hvert af vurderingstidspunkterne og den kumulative forekomst af kognitiv svigt, hvor dødsfald vurderes som en konkurrerende risiko. CFFS-raterne på de skelsættende tidspunkter vil blive estimeret ved hjælp af metoden fra Kaplan-Meier, og forskellen i rater vil blive evalueret ved hjælp af et 90 % konfidensinterval ved hjælp af Greenwood?s formel.
Baseline til første neurokognitiv svigt CF eller død på grund af enhver årsag, vurderet til 90, 180, 270, 360, 540 og 720 dage efter randomisering
Kumulativ forekomst af kognitiv svigt
Tidsramme: Neurokognitiv funktionstest vil blive vurderet 90, 180, 270, 360, 540 og 720 dage efter randomisering
Den kumulative forekomst af kognitiv svigt i nærvær af den konkurrerende risiko for død vil blive estimeret ved hjælp af metoden Fine og Grey.
Neurokognitiv funktionstest vil blive vurderet 90, 180, 270, 360, 540 og 720 dage efter randomisering
OS i en "som-behandlet" analyse
Tidsramme: Fra registreringsdatoen til datoen for dødsfald på grund af enhver årsag, vurderet op til 2 år efter randomisering. Patienterne vil blive set på dag 90, 180, 270, 360, 540 og 720
Sammenligningen af ​​OS i ?as-treated? analyse vil blive udført som beskrevet for den primære analyse, dog vil patienter blive kategoriseret pr. modtaget behandling (patienter, der ikke accepterer deres randomiserede tildeling, vil blive analyseret pr. modtaget behandling). Antallet af patienter, der ikke accepterer den randomiserede opgave, vil også blive opsummeret.
Fra registreringsdatoen til datoen for dødsfald på grund af enhver årsag, vurderet op til 2 år efter randomisering. Patienterne vil blive set på dag 90, 180, 270, 360, 540 og 720
Hjernemetastasefri overlevelse (BMFS)
Tidsramme: Op til 2 år efter randomisering. Patienter vil have MR på dag 90, 180, 270, 360, 540 og 720
Dette vil blive estimeret ved hjælp af metoden fra Kaplan-Meier, og sammenligninger vil blive udført ved hjælp af en log-rank test på 1-sidet 0,05 niveau. Fareforhold og tilhørende konfidensintervaller vil blive estimeret ved hjælp af en Cox Proportional Hazards model. Konfidensintervaller for medianer vil blive estimeret ved brug af Brookmeyer-Crowleys metode.
Op til 2 år efter randomisering. Patienter vil have MR på dag 90, 180, 270, 360, 540 og 720
Forekomst af uønskede hændelser
Tidsramme: Op til 2 år efter randomisering. Patienter vil blive vurderet for uønskede hændelser efter PCI (for patienter på PCI + MR-arm) og ved 3. måned (alle patienter)
Binære proportioner og tilhørende konfidensintervaller vil blive estimeret.
Op til 2 år efter randomisering. Patienter vil blive vurderet for uønskede hændelser efter PCI (for patienter på PCI + MR-arm) og ved 3. måned (alle patienter)

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

SWOG Cancer Research Network

Samarbejdspartnere

National Cancer Institute (NCI)

Efterforskere

  • Ledende efterforsker: Chad G Rusthoven, SWOG Cancer Research Network

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

4. maj 2020

Primær færdiggørelse (Faktiske)

17. marts 2026

Studieafslutning (Anslået)

15. november 2029

Datoer for studieregistrering

Først indsendt

5. november 2019

Først indsendt, der opfyldte QC-kriterier

5. november 2019

Først opslået (Faktiske)

7. november 2019

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

11. juni 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

9. juni 2026

Sidst verificeret

1. juni 2026

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • S1827 (Anden identifikator: CTEP)
  • U10CA180888 (U.S. NIH-bevilling/kontrakt)
  • NCI-2019-05338 (Registry Identifier: CTRP (Clinical Trial Reporting Program))

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Ingen

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ja

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

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