Denne side blev automatisk oversat, og nøjagtigheden af oversættelsen er ikke garanteret. Der henvises til engelsk version for en kildetekst.

Undersøgelse af Inclisiran for at forhindre kardiovaskulære (CV) hændelser hos deltagere med etableret kardiovaskulær sygdom (VICTORION-2P)

8. maj 2026 opdateret af: Novartis Pharmaceuticals

Et randomiseret, dobbeltblindt, placebokontrolleret, multicenterforsøg, der vurderer virkningen af Inclisiran på alvorlige uønskede kardiovaskulære hændelser hos deltagere med etableret kardiovaskulær sygdom (VICTORION-2 PREVENT)

Undersøgelse CKJX839B12302 er et pivotalt fase III-forsøg til at evaluere fordelene ved inclisiran på alvorlige uønskede kardiovaskulære (MACE) hændelser hos deltagere med etableret kardiovaskulær sygdom (CVD).

Studieoversigt

Status

Aktiv, ikke rekrutterende

Betingelser

Aterosklerotisk kardiovaskulær sygdom

Intervention / Behandling

Detaljeret beskrivelse

Formålet med denne undersøgelse er at teste hypotesen om, at behandling med inclisiran natrium 300 mg s.c. administreret på dag 1, måned 3 (dag 90) og hver 6. måned derefter taget som supplement til veltolereret højintensiv statinbehandling hos deltagere med etableret ASCVD vil signifikant reducere risikoen for 3-punkts-større kardiovaskulære hændelser (3P -MACE) defineret som en sammensætning af CV-død, ikke-fatalt myokardieinfarkt (MI) og ikke-fatalt iskæmisk slagtilfælde. Dette vil blive sammenlignet med placebo i tillæg til veltolereret højintensiv statinbehandling.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

17004

Fase

Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Argentina
- - Buenos Aires, Argentina, C1012AAR
    - Novartis Investigative Site
  - Buenos Aires, Argentina, C1428DCO
    - Novartis Investigative Site
  - Buenos Aires, Argentina, C1425AGP
    - Novartis Investigative Site
  - Caba, Argentina, C1426
    - Novartis Investigative Site
  - Corrientes, Argentina, W3400CDS
    - Novartis Investigative Site
  - Córdoba, Argentina, X5002
    - Novartis Investigative Site
  - Mendoza, Argentina, 5500
    - Novartis Investigative Site
  - Santa Fe, Argentina, S3000EOZ
    - Novartis Investigative Site
- Buenos Aires
  - CABA, Buenos Aires, Argentina, C1221ADC
    - Novartis Investigative Site
  - CABA, Buenos Aires, Argentina, C1405BCH
    - Novartis Investigative Site
  - CABA, Buenos Aires, Argentina, C1056ABI
    - Novartis Investigative Site
  - CABA, Buenos Aires, Argentina, 1280
    - Novartis Investigative Site
  - CABA, Buenos Aires, Argentina, 1426
    - Novartis Investigative Site
  - CABA, Buenos Aires, Argentina, C1187AAN
    - Novartis Investigative Site
  - Caba, Buenos Aires, Argentina, C1119ACN
    - Novartis Investigative Site
  - Mar del Plata, Buenos Aires, Argentina, 7600
    - Novartis Investigative Site
  - Quilmes, Buenos Aires, Argentina, B1878GEG
    - Novartis Investigative Site
  - Ramos Mejía, Buenos Aires, Argentina, B1704ETD
    - Novartis Investigative Site
  - San Martín, Buenos Aires, Argentina, B1650CSQ
    - Novartis Investigative Site
- Córdoba Province
  - Córdoba, Córdoba Province, Argentina, 5000
    - Novartis Investigative Site
- Formosa Province
  - Formosa, Formosa Province, Argentina, P3600
    - Novartis Investigative Site
- Misiones Province
  - Posadas, Misiones Province, Argentina, N3300
    - Novartis Investigative Site
- Salta Province
  - Salta, Salta Province, Argentina, A4406BPF
    - Novartis Investigative Site
- San Miguel de Tucuman
  - San Miguel de Tucumán, San Miguel de Tucuman, Argentina, T4000ICL
    - Novartis Investigative Site
- Santa Fe Province
  - Rosario, Santa Fe Province, Argentina, 2000
    - Novartis Investigative Site
  - Rosario, Santa Fe Province, Argentina, S2000AII
    - Novartis Investigative Site
  - Rosario, Santa Fe Province, Argentina, S200CVD
    - Novartis Investigative Site
  - Santa Fe, Santa Fe Province, Argentina, S3000FWO
    - Novartis Investigative Site
- Tucumán Province
  - San Miguel Tucuman, Tucumán Province, Argentina, T4000IFL
    - Novartis Investigative Site
Australien
- - Liverpool, Australien, 2170
    - Novartis Investigative Site
- New South Wales
  - Botany, New South Wales, Australien, 2019
    - Novartis Investigative Site
  - New Lambton Heights, New South Wales, Australien, 2305
    - Novartis Investigative Site
- Queensland
  - Auchenflower, Queensland, Australien, 4066
    - Novartis Investigative Site
  - Milton, Queensland, Australien, 4064
    - Novartis Investigative Site
  - Woolloongabba, Queensland, Australien, 4102
    - Novartis Investigative Site
- South Australia
  - Adelaide, South Australia, Australien, 5000
    - Novartis Investigative Site
  - Bedford Park, South Australia, Australien, 5041
    - Novartis Investigative Site
  - Leabrook, South Australia, Australien, 5068
    - Novartis Investigative Site
  - Woodville South, South Australia, Australien, 5011
    - Novartis Investigative Site
- Victoria
  - Clayton, Victoria, Australien, 3168
    - Novartis Investigative Site
  - Geelong, Victoria, Australien, 3220
    - Novartis Investigative Site
  - Malvern East, Victoria, Australien, 3145
    - Novartis Investigative Site
  - Richmond, Victoria, Australien, 3121
    - Novartis Investigative Site
- Western Australia
  - Joondalup, Western Australia, Australien, 6027
    - Novartis Investigative Site
  - Nedlands, Western Australia, Australien, 6009
    - Novartis Investigative Site
Belgien
- - Antwerp, Belgien, 2020
    - Novartis Investigative Site
  - Brasschaat, Belgien, 2930
    - Novartis Investigative Site
  - Bruges, Belgien, 8000
    - Novartis Investigative Site
  - Brussels, Belgien, 1020
    - Novartis Investigative Site
  - Charleroi, Belgien, 6000
    - Novartis Investigative Site
  - Edegem, Belgien, 2650
    - Novartis Investigative Site
  - Ghent, Belgien, 9000
    - Novartis Investigative Site
  - La Louvière, Belgien, 7100
    - Novartis Investigative Site
  - Ronse, Belgien, 9600
    - Novartis Investigative Site
- Limburg
  - Genk, Limburg, Belgien, 3600
    - Novartis Investigative Site
- Namur
  - Yvoir, Namur, Belgien, 5530
    - Novartis Investigative Site
- West-Vlaanderen
  - Kortrijk, West-Vlaanderen, Belgien, 8500
    - Novartis Investigative Site
  - Roeselare, West-Vlaanderen, Belgien, 8800
    - Novartis Investigative Site
Brasilien
- - Campinas, Brasilien, 13092-133
    - Novartis Investigative Site
  - Rio de Janeiro, Brasilien, 20241-180
    - Novartis Investigative Site
  - São Paulo, Brasilien, 04026-090
    - Novartis Investigative Site
- Alagoas
  - Maceió, Alagoas, Brasilien, 57051-160
    - Novartis Investigative Site
- Espírito Santo
  - Vitória, Espírito Santo, Brasilien, 29055-450
    - Novartis Investigative Site
- Estado de Bahia
  - Salvador, Estado de Bahia, Brasilien, 40170-130
    - Novartis Investigative Site
- Federal District
  - Brasília, Federal District, Brasilien, 71625-009
    - Novartis Investigative Site
  - Brasília, Federal District, Brasilien, 70390-700
    - Novartis Investigative Site
- Minas Gerais
  - Belo Horizonte, Minas Gerais, Brasilien, 30220-330
    - Novartis Investigative Site
  - Uberlândia, Minas Gerais, Brasilien, 38400 500
    - Novartis Investigative Site
- Paraná
  - Curitiba, Paraná, Brasilien, 80730-150
    - Novartis Investigative Site
- Rio Grande do Sul
  - Canoas, Rio Grande do Sul, Brasilien, 92425-900
    - Novartis Investigative Site
  - Pelotas, Rio Grande do Sul, Brasilien, 96015-290
    - Novartis Investigative Site
  - Porto Alegre, Rio Grande do Sul, Brasilien, 90880-480
    - Novartis Investigative Site
  - Porto Alegre, Rio Grande do Sul, Brasilien, 90560-032
    - Novartis Investigative Site
  - Porto Alegre, Rio Grande do Sul, Brasilien, 90160-093
    - Novartis Investigative Site
- Santa Catarina
  - Blumenau, Santa Catarina, Brasilien, 89020-430
    - Novartis Investigative Site
- Sergipe
  - Aracaju, Sergipe, Brasilien, 49055-530
    - Novartis Investigative Site
- São Paulo
  - Campinas, São Paulo, Brasilien, 13060 080
    - Novartis Investigative Site
  - Ribeirão Preto, São Paulo, Brasilien, 14048-900
    - Novartis Investigative Site
  - Santo André, São Paulo, Brasilien, 09030-010
    - Novartis Investigative Site
  - Santo André, São Paulo, Brasilien, 09060-870
    - Novartis Investigative Site
  - Santo André, São Paulo, Brasilien, 09090-790
    - Novartis Investigative Site
  - Sao Jose Rio Preto, São Paulo, Brasilien, 15015-750
    - Novartis Investigative Site
  - Sao Jose Rio Preto, São Paulo, Brasilien, 15090-000
    - Novartis Investigative Site
  - São Paulo, São Paulo, Brasilien, 01323-903
    - Novartis Investigative Site
  - São Paulo, São Paulo, Brasilien, 04005-003
    - Novartis Investigative Site
  - São Paulo, São Paulo, Brasilien, 04266 010
    - Novartis Investigative Site
  - São Paulo, São Paulo, Brasilien, 05403 000
    - Novartis Investigative Site
  - São Paulo, São Paulo, Brasilien, 09715 090
    - Novartis Investigative Site
Bulgarien
- - Burgas, Bulgarien, 8000
    - Novartis Investigative Site
  - Haskovo, Bulgarien, 6304
    - Novartis Investigative Site
  - Kyustendil, Bulgarien, 2500
    - Novartis Investigative Site
  - Montana, Bulgarien, 3400
    - Novartis Investigative Site
  - Pernik, Bulgarien, 2300
    - Novartis Investigative Site
  - Pleven, Bulgarien, 5800
    - Novartis Investigative Site
  - Plovdiv, Bulgarien, 4000
    - Novartis Investigative Site
  - Rousse, Bulgarien, 7000
    - Novartis Investigative Site
  - Sliven, Bulgarien, 8800
    - Novartis Investigative Site
  - Sofia, Bulgarien, 1527
    - Novartis Investigative Site
  - Sofia, Bulgarien, 1113
    - Novartis Investigative Site
  - Sofia, Bulgarien, 1431
    - Novartis Investigative Site
  - Sofia, Bulgarien, 1407
    - Novartis Investigative Site
  - Sofia, Bulgarien, 1750
    - Novartis Investigative Site
  - Sofia, Bulgarien, 1510
    - Novartis Investigative Site
  - Sofia, Bulgarien, 1582
    - Novartis Investigative Site
  - Stamboliyski, Bulgarien, 4210
    - Novartis Investigative Site
  - Stara Zagora, Bulgarien, 6000
    - Novartis Investigative Site
  - Stara Zagora, Bulgarien, 6003
    - Novartis Investigative Site
  - Veliko Tarnovo, Bulgarien, 5000
    - Novartis Investigative Site
- Blagoevgrad
  - Sandanski, Blagoevgrad, Bulgarien, 2850
    - Novartis Investigative Site
- Bulgaria
  - Rousse, Bulgaria, Bulgarien, 7012
    - Novartis Investigative Site
  - Sofia, Bulgaria, Bulgarien, 1202
    - Novartis Investigative Site
  - Stara Zagora, Bulgaria, Bulgarien, 6000
    - Novartis Investigative Site
- Burgas
  - Burgas, Burgas, Bulgarien, 8000
    - Novartis Investigative Site
- Sofia-Grad
  - Sofia, Sofia-Grad, Bulgarien, 1040
    - Novartis Investigative Site
Canada
- Alberta
  - Calgary, Alberta, Canada, T2N 4N1
    - Novartis Investigative Site
  - Edmonton, Alberta, Canada, T5H 4B9
    - Novartis Investigative Site
  - Edmonton, Alberta, Canada, T6K 4C1
    - Novartis Investigative Site
- British Columbia
  - North Vancouver, British Columbia, Canada, V7M 2H4
    - Novartis Investigative Site
  - Vancouver, British Columbia, Canada, V6Z 1Y6
    - Novartis Investigative Site
  - Vancouver, British Columbia, Canada, V5Z 1M9
    - Novartis Investigative Site
  - Victoria, British Columbia, Canada, V8R4R2
    - Novartis Investigative Site
  - Victoria, British Columbia, Canada, V8T 5G4
    - Novartis Investigative Site
  - Victoria, British Columbia, Canada, V8V 4A1
    - Novartis Investigative Site
- Manitoba
  - Winnipeg, Manitoba, Canada, R3C 0N2
    - Novartis Investigative Site
  - Winnipeg, Manitoba, Canada, R3L 1Z5
    - Novartis Investigative Site
- New Brunswick
  - Moncton, New Brunswick, Canada, E1G 1A7
    - Novartis Investigative Site
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 2Y9
    - Novartis Investigative Site
  - Sydney, Nova Scotia, Canada, B1P 1P3
    - Novartis Investigative Site
- Ontario
  - Cambridge, Ontario, Canada, N1R 7R1
    - Novartis Investigative Site
  - Guelph, Ontario, Canada, N1H 1B1
    - Novartis Investigative Site
  - Newmarket, Ontario, Canada, L3Y 2P6
    - Novartis Investigative Site
  - Oakville, Ontario, Canada, L6K 3W7
    - Novartis Investigative Site
  - Peterborough, Ontario, Canada, K9J 0B2
    - Novartis Investigative Site
  - Sarnia, Ontario, Canada, N7T 4X3
    - Novartis Investigative Site
  - Scarborough Village, Ontario, Canada, M1B 4Z8
    - Novartis Investigative Site
  - Scarborough Village, Ontario, Canada, M1B 5N1
    - Novartis Investigative Site
  - Stoufville, Ontario, Canada, L4A 1H2
    - Novartis Investigative Site
- Quebec
  - Greenfield Park, Quebec, Canada, J4V 2G8
    - Novartis Investigative Site
  - Montreal, Quebec, Canada, H2X 1R9
    - Novartis Investigative Site
  - Montreal, Quebec, Canada, H3M 1L3
    - Novartis Investigative Site
  - Montreal, Quebec, Canada, H4N 2W2
    - Novartis Investigative Site
  - Québec, Quebec, Canada, G1W 4R4
    - Novartis Investigative Site
  - Québec, Quebec, Canada, G2J 0C4
    - Novartis Investigative Site
  - Québec, Quebec, Canada, G1V 4G5
    - Novartis Investigative Site
  - Saint-Jérôme, Quebec, Canada, J7Z 5T3
    - Novartis Investigative Site
  - Sainte-Foy, Quebec, Canada, G1V 4G2
    - Novartis Investigative Site
  - Terrebonne, Quebec, Canada, J6V 2H2
    - Novartis Investigative Site
  - Trois-Rivières, Quebec, Canada, G8Z 3R9
    - Novartis Investigative Site
Chile
- - Santiago, Chile, 8380456
    - Novartis Investigative Site
- Araucania
  - Temuco, Araucania, Chile, 4781156
    - Novartis Investigative Site
  - Victoria, Araucania, Chile, 4720097
    - Novartis Investigative Site
- Coquimbo Region
  - La Serena, Coquimbo Region, Chile, 1720430
    - Novartis Investigative Site
- Los Lagos Region
  - Osorno, Los Lagos Region, Chile, 5290000
    - Novartis Investigative Site
- Santiago Metropolitan
  - Santiago, Santiago Metropolitan, Chile, 8331143
    - Novartis Investigative Site
  - Santiago, Santiago Metropolitan, Chile, 7500710
    - Novartis Investigative Site
  - Santiago, Santiago Metropolitan, Chile, 8380465
    - Novartis Investigative Site
- Valparaiso
  - Viña del Mar, Valparaiso, Chile, 2520997
    - Novartis Investigative Site
Colombia
- - Bogotá, Colombia, 110221
    - Novartis Investigative Site
  - Floridablanca, Colombia, 681017
    - Novartis Investigative Site
- Antioquia
  - Medellín, Antioquia, Colombia, 050021
    - Novartis Investigative Site
  - Medellín, Antioquia, Colombia, 050036
    - Novartis Investigative Site
- Atlántico
  - Barranquilla, Atlántico, Colombia, 080002
    - Novartis Investigative Site
  - Barranquilla, Atlántico, Colombia, 080020
    - Novartis Investigative Site
- Caldas Department
  - Manizales, Caldas Department, Colombia, 1700
    - Novartis Investigative Site
- Colombia
  - Barranquilla, Colombia, Colombia, 080020
    - Novartis Investigative Site
  - Cali, Colombia, Colombia, 760024
    - Novartis Investigative Site
- Departamento de Bolívar
  - Cartagena, Departamento de Bolívar, Colombia, 130001
    - Novartis Investigative Site
- Risaralda Department
  - Pereira, Risaralda Department, Colombia, 660003
    - Novartis Investigative Site
- Valle del Cauca Department
  - Cali, Valle del Cauca Department, Colombia, 760001
    - Novartis Investigative Site
  - Cali, Valle del Cauca Department, Colombia, 760032
    - Novartis Investigative Site
Danmark
- - Aarhus N, Danmark, 8200
    - Novartis Investigative Site
  - Esbjerg, Danmark, 6700
    - Novartis Investigative Site
  - Glostrup Municipality, Danmark, DK-2600
    - Novartis Investigative Site
  - Herlev, Danmark, 2730
    - Novartis Investigative Site
  - Hjørring, Danmark, 9800
    - Novartis Investigative Site
  - Roskilde, Danmark, 4000
    - Novartis Investigative Site
  - Svendborg, Danmark, 5700
    - Novartis Investigative Site
  - Viborg, Danmark, 8800
    - Novartis Investigative Site
- Central Jutland
  - Herning, Central Jutland, Danmark, 7400
    - Novartis Investigative Site
Estland
- - Pärnu, Estland, 80018
    - Novartis Investigative Site
  - Tallinn, Estland, 13419
    - Novartis Investigative Site
  - Tallinn, Estland, 10138
    - Novartis Investigative Site
  - Tallinn, Estland, 13619
    - Novartis Investigative Site
  - Tallinn, Estland, 10117
    - Novartis Investigative Site
  - Tartu, Estland, 50406
    - Novartis Investigative Site
  - Tartu, Estland, 50708
    - Novartis Investigative Site
Filippinerne
- - Quezon, Filippinerne, 1102
    - Novartis Investigative Site
  - San Juan City, Filippinerne, 1502
    - Novartis Investigative Site
- Iloilo
  - Iloilo City, Iloilo, Filippinerne, 5000
    - Novartis Investigative Site
- Pampanga
  - San Fernando City, Pampanga, Filippinerne, 2000
    - Novartis Investigative Site
Finland
- - Helsinki, Finland, 370
    - Novartis Investigative Site
  - Jyväskylä, Finland, 40620
    - Novartis Investigative Site
  - Turku, Finland, 20520
    - Novartis Investigative Site
  - Turku, Finland, 20100
    - Novartis Investigative Site
- Northern Savonia
  - Kuopio, Northern Savonia, Finland, 70600
    - Novartis Investigative Site
Forenede Stater
- Alabama
  - Birmingham, Alabama, Forenede Stater, 35211
    - UAB St Vincents
  - Fairhope, Alabama, Forenede Stater, 36532
    - Eastern Shore Research Institute
  - Foley, Alabama, Forenede Stater, 36535
    - G and L Research LLC
- Alaska
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Heart and Vascular
- Arizona
  - Gilbert, Arizona, Forenede Stater, 85297
    - Mercy Gilbert Medical Center
  - Mesa, Arizona, Forenede Stater, 85206
    - CardioVascular Associates of Mesa
  - Phoenix, Arizona, Forenede Stater, 85018
    - Elite Clinical Studies
  - Scottsdale, Arizona, Forenede Stater, 85258
    - HonorHealth Heart Group Deer Valley
  - Sun City West, Arizona, Forenede Stater, 85375
    - Clinical Research Inst of Arizona
  - Tucson, Arizona, Forenede Stater, 85741
    - Pima Heart And Vascular Clin Rch
- Arkansas
  - Little Rock, Arkansas, Forenede Stater, 72205
    - Arkansas Clinical Research
  - Little Rock, Arkansas, Forenede Stater, 72205
    - ARcare Center for Clinical Research
- California
  - Bakersfield, California, Forenede Stater, 93308
    - Central Cardiology Medical Center
  - Canoga Park, California, Forenede Stater, 91303
    - Alliance Clinical
  - Chino, California, Forenede Stater, 91710
    - Inland Psychiatric Medical Group
  - Concord, California, Forenede Stater, 94520
    - John Muir Physician Network Clinical Research Center
  - Fullerton, California, Forenede Stater, 92835
    - Triallogix
  - Huntington Beach, California, Forenede Stater, 92648
    - Diabetes Lipid Management Center
  - Irvine, California, Forenede Stater, 92660
    - University of Calif Irvine Med Cntr
  - La Jolla, California, Forenede Stater, 92037
    - UC San Diego Health
  - Los Angeles, California, Forenede Stater, 90017
    - American Institute of Research
  - Los Angeles, California, Forenede Stater, 90095
    - University of California LA
  - Los Angeles, California, Forenede Stater, 90033
    - Keck Medical Center USC
  - Palo Alto, California, Forenede Stater, 94304-1207
    - VA Palo Alto Health Care System
  - San Diego, California, Forenede Stater, 92161
    - San Diego Veterans Medical Center
  - San Ramon, California, Forenede Stater, 94582
    - West Coast Research LLC
  - Santa Ana, California, Forenede Stater, 92705
    - Syrentis Clinical Research
  - Santa Ana, California, Forenede Stater, 92704
    - Helping Hands Medical Associates INC
  - Spring Valley, California, Forenede Stater, 91978
    - Encompass Clinical Research
  - Stanford, California, Forenede Stater, 94304
    - Stanford University Medical Center
  - Stockton, California, Forenede Stater, 95204
    - Manshadi Heart Institute
  - Torrance, California, Forenede Stater, 90502
    - Harbor Ucla Medical Center
  - Vista, California, Forenede Stater, 92081
    - Blue Coast Research Center LLC
  - West Hills, California, Forenede Stater, 91307
    - Interv Cardiology Med Grp
- Colorado
  - Aurora, Colorado, Forenede Stater, 80012
    - Aurora Denver Cardiology Associates
  - Aurora, Colorado, Forenede Stater, 80045
    - Rocky Mountain Regional VA Med Ctr
- Connecticut
  - Bridgeport, Connecticut, Forenede Stater, 06610
    - Bridgeport Hospital
  - Greenwich, Connecticut, Forenede Stater, 06830
    - d-b-a Greenwich Cardio Assoc
  - Waterbury, Connecticut, Forenede Stater, 06708
    - Chase Medical Research LLC
- District of Columbia
  - Washington D.C., District of Columbia, Forenede Stater, 20020
    - Emerson Clinical Research Institute
- Florida
  - Boca Raton, Florida, Forenede Stater, 33434
    - Excel Medical Clinical Trials LLC
  - Bradenton, Florida, Forenede Stater, 34209
    - Cardiovascular and Vein Center of Florida
  - Bradenton, Florida, Forenede Stater, 34209
    - Nova Clinical Research LLC
  - Clearwater, Florida, Forenede Stater, 33756
    - Bay Care Medical Group
  - Daytona Beach, Florida, Forenede Stater, 32117
    - Cardiology Research Associates
  - DeLand, Florida, Forenede Stater, 32720
    - Hillcrest Medical Research
  - Hialeah, Florida, Forenede Stater, 33012
    - Indago Research and Health Ctr Inc
  - Hialeah, Florida, Forenede Stater, 33013
    - National Research Institute
  - Hialeah, Florida, Forenede Stater, 33013
    - Sister Life Research Inc
  - Hollywood, Florida, Forenede Stater, 33021
    - Zenith clinical research
  - Jacksonville, Florida, Forenede Stater, 32205
    - Westside Center for Clinical Research
  - Jacksonville, Florida, Forenede Stater, 32209
    - UF Health Science Center
  - Jacksonville Beach, Florida, Forenede Stater, 32250
    - Baptist Heart Specialists
  - Lake Worth, Florida, Forenede Stater, 33461
    - United Vein and Vascular Centers
  - Miami, Florida, Forenede Stater, 33133
    - Infinite Clinical Research
  - Miami, Florida, Forenede Stater, 33186
    - A&A Research Group Inc
  - Miami Lakes, Florida, Forenede Stater, 33014
    - Inpatient Research Clinical LLC
  - Miami Lakes, Florida, Forenede Stater, 33014
    - RM Medical Research Inc
  - Miramar, Florida, Forenede Stater, 33027
    - FXM Clin Res Miramar LLC
  - Naples, Florida, Forenede Stater, 34102
    - Advanced Research for Health Improvement LLC
  - Ocala, Florida, Forenede Stater, 34471
    - Ocala Cardiovascular Research
  - Oviedo, Florida, Forenede Stater, 32765
    - Oviedo Medical Research
  - Palm Springs, Florida, Forenede Stater, 33406
    - CTMD Research
  - Pembroke Pines, Florida, Forenede Stater, 33024
    - Broward Research Center
  - Pensacola, Florida, Forenede Stater, 32503
    - SEC Clinical Research
  - Port Charlotte, Florida, Forenede Stater, 33952
    - Peace River Cardiovascular Center
  - St. Petersburg, Florida, Forenede Stater, 33713
    - Advanced Medical Research Center
  - Tampa, Florida, Forenede Stater, 33614
    - BayCare Medical Group Inc
  - Tampa, Florida, Forenede Stater, 33614
    - Genesis Clinical Research
  - Tampa, Florida, Forenede Stater, 33603
    - New Tampa Health
  - Tampa, Florida, Forenede Stater, 33880
    - Ravessa Clinical Research
  - Tampa, Florida, Forenede Stater, 33612
    - James A Haley Veterans Hospital
  - Tampa, Florida, Forenede Stater, 33705
    - BayCare Health System
  - Wellington, Florida, Forenede Stater, 33449
    - Cardiology Partners Clinical Research Institute
- Georgia
  - Fayetteville, Georgia, Forenede Stater, 30214
    - Javara Research
  - Gainsville, Georgia, Forenede Stater, 30501
    - Northeast Georgia Medical Center
  - Peachtree Corners, Georgia, Forenede Stater, 30092
    - Alta Pharmaceutical Research Center
  - Tucker, Georgia, Forenede Stater, 30084
    - Atlanta Heart Specialists LLC
- Idaho
  - Meridian, Idaho, Forenede Stater, 83646
    - Solaris Clinical Research
  - Nampa, Idaho, Forenede Stater, 83686
    - Saltzer Health
- Illinois
  - Addison, Illinois, Forenede Stater, 60101
    - Biofortis Research
  - Arlington Heights, Illinois, Forenede Stater, 60005
    - Endeavor Health Clinical Op- NCH
  - Chicago, Illinois, Forenede Stater, 60607
    - Cedar Crosse Research Ct
  - Chicago, Illinois, Forenede Stater, 60607
    - Chicago Clinical Research Inst
  - Jerseyville, Illinois, Forenede Stater, 62052
    - Gateway Cardiology PC
  - Peoria, Illinois, Forenede Stater, 61603
    - Methodist Med Center Of Illinois
  - Springfield, Illinois, Forenede Stater, 62702
    - SIU School of Medicine
  - Springfield, Illinois, Forenede Stater, 62769
    - Prairie Heart Institute
- Indiana
  - Elkhart, Indiana, Forenede Stater, 46514
    - Elkhart Cardiology Group
  - Indianapolis, Indiana, Forenede Stater, 46237
    - Franciscan Health Services Research Center
  - Lebanon, Indiana, Forenede Stater, 46052
    - Witham Heart Partners
  - Merrillville, Indiana, Forenede Stater, 46410
    - The Heart Center of Lake County
  - Munster, Indiana, Forenede Stater, 46321
    - Cardiovascular Research of Northwest Indiana, LLC
- Iowa
  - Waterloo, Iowa, Forenede Stater, 50702
    - Covenant Medical Center
- Kansas
  - Kansas City, Kansas, Forenede Stater, 66160
    - University of Kansas Hospital
  - Overland Park, Kansas, Forenede Stater, 66211
    - Midwest Heart and Vascular Spec
  - Topeka, Kansas, Forenede Stater, 66606
    - Cotton O Neil Clinical Res Center
  - Wichita, Kansas, Forenede Stater, 67214
    - Ascension via Christi Research
- Kentucky
  - Lexington, Kentucky, Forenede Stater, 40536
    - University of Kentucky College of Health Sciences
  - Louisville, Kentucky, Forenede Stater, 40202
    - U of Louisville Rudd Heart and Lung
- Louisiana
  - Alexandria, Louisiana, Forenede Stater, 71301
    - Christus Health Central Louisiana
  - Baton Rouge, Louisiana, Forenede Stater, 70808
    - Louisiana Cardiology Associates
  - Bossier City, Louisiana, Forenede Stater, 71111
    - Grace Research Llc
  - Covington, Louisiana, Forenede Stater, 70433
    - Cardiovascular Associates Research
  - Covington, Louisiana, Forenede Stater, 70433
    - Louisiana Heart Center Research
  - Crowley, Louisiana, Forenede Stater, 70526
    - Avant Research Associates LLC
  - Eunice, Louisiana, Forenede Stater, 70535
    - Horizon Research Group of Opelousas LLC
  - Gray, Louisiana, Forenede Stater, 70359
    - Cardiovascular Institute South ASC
  - Hammond, Louisiana, Forenede Stater, 70403
    - Heart Clinic of Hammond
  - Lafayette, Louisiana, Forenede Stater, 70503
    - CV Ins of the South
  - Mandeville, Louisiana, Forenede Stater, 70471
    - Clinical Trials Management LLC
  - Mandeville, Louisiana, Forenede Stater, 70448
    - North Shore Heart and Vascular
  - Metairie, Louisiana, Forenede Stater, 70006
    - Omega Clinical Research
  - Monroe, Louisiana, Forenede Stater, 71201
    - Clinical Trials of America LA LLC
  - Natchitoches, Louisiana, Forenede Stater, 71457
    - Barnum Medical Research Inc
  - New Orleans, Louisiana, Forenede Stater, 70115
    - Crescent City Physicians Inc
  - Opelousas, Louisiana, Forenede Stater, 70570
    - CV Ins of the South
  - Shreveport, Louisiana, Forenede Stater, 71105
    - Grace Research Llc
  - Slidell, Louisiana, Forenede Stater, 70458
    - Louisiana Heart Center Research
  - Zachary, Louisiana, Forenede Stater, 70791
    - Southern Clinical Research
- Maryland
  - Baltimore, Maryland, Forenede Stater, 21209
    - Sinai Ct for Throm Res and Drug Dev
  - Beltsville, Maryland, Forenede Stater, 20705
    - Metropolitan Cardiovascular Consultants LLC
  - Columbia, Maryland, Forenede Stater, 21044
    - Johns Hopkins University
  - Ft. Washington, Maryland, Forenede Stater, 20744
    - Anderson Medical Research
  - Glenn Dale, Maryland, Forenede Stater, 20769
    - Javara Inc
  - Lanham, Maryland, Forenede Stater, 20706
    - Capitol Cardiology Associates
  - Oxon Hill, Maryland, Forenede Stater, 20745
    - MD Medical Research
  - Rockville, Maryland, Forenede Stater, 20850
    - Adventist HealthCare Shady Grove Medical Center
  - Salisbury, Maryland, Forenede Stater, 21804
    - Tidal Health Peninsula Regional Inc
- Massachusetts
  - Boston, Massachusetts, Forenede Stater, 02215
    - Beth Israel Deaconess Medical Center
  - Boston, Massachusetts, Forenede Stater, 02111
    - Tufts Medical Center
  - Boston, Massachusetts, Forenede Stater, 02115
    - Dana Farber Cancer Institute
  - Boston, Massachusetts, Forenede Stater, 02132
    - VA Boston Healthcare System
  - Methuen, Massachusetts, Forenede Stater, 01844
    - ActivMed Practices and Research
- Michigan
  - Detroit, Michigan, Forenede Stater, 48202
    - Henry Ford Hospital
  - Flint, Michigan, Forenede Stater, 48504
    - AA Medical Research Center
  - Grand Rapids, Michigan, Forenede Stater, 49546
    - Healthy Heart Cardiology
  - Lansing, Michigan, Forenede Stater, 48910
    - McLaren Greater Lansing
  - Midland, Michigan, Forenede Stater, 48670
    - MyMichigan Medical Center Midland
  - Saginaw, Michigan, Forenede Stater, 48601
    - Central Michigan University
  - Southfield, Michigan, Forenede Stater, 48075
    - Providence Hospital Patient Care Research
  - Traverse City, Michigan, Forenede Stater, 49684
    - Traverse Heart and Vascular
  - Ypsilanti, Michigan, Forenede Stater, 48197
    - Trinity Health Michigan Heart
- Minnesota
  - Duluth, Minnesota, Forenede Stater, 55805
    - St Marys Medical Center
  - Minneapolis, Minnesota, Forenede Stater, 55455
    - University of Minnesota
  - Robbinsdale, Minnesota, Forenede Stater, 55422
    - North Memorial Heart and Vascular Institute
  - Saint Cloud, Minnesota, Forenede Stater, 56303
    - Centracare Heart and Vascular Center
  - Saint Louis Park, Minnesota, Forenede Stater, 55426
    - Methodist Hospital
  - Saint Paul, Minnesota, Forenede Stater, 55101
    - Regions Hospital
- Mississippi
  - Belzoni, Mississippi, Forenede Stater, 39038
    - Belzoni Clinical Research
  - Jackson, Mississippi, Forenede Stater, 39216
    - Jackson Heart Clinic
  - Jackson, Mississippi, Forenede Stater, 39216
    - VAMC Research-G V Sonny Montgomery Clinic
  - Tupelo, Mississippi, Forenede Stater, 38801
    - Cardiology Associates of North MS
  - Yazoo City, Mississippi, Forenede Stater, 39194
    - Yazoo Clinical Research
  - Yazoo City, Mississippi, Forenede Stater, 39194
    - Yazoo Clinical Research .
- Missouri
  - Kansas City, Missouri, Forenede Stater, 64128
    - Kansas City VA Medical Center
  - North Kansas City, Missouri, Forenede Stater, 64116
    - North Kansas City Hospital
  - Springfield, Missouri, Forenede Stater, 65804
    - Mercy Hospital
  - St Louis, Missouri, Forenede Stater, 63128
    - Mercy South
  - St Louis, Missouri, Forenede Stater, 63125-4181
    - St Louis V A Medical Center
  - St Louis, Missouri, Forenede Stater, 63128
    - Gateway Cardiovascular Rsch Ctr Inc
  - St Louis, Missouri, Forenede Stater, 63136
    - St Louis Heart and Vascular
- Nebraska
  - Lincoln, Nebraska, Forenede Stater, 68516
    - Physician Research Collaboration
  - Omaha, Nebraska, Forenede Stater, 68130
    - CCT Research
  - Omaha, Nebraska, Forenede Stater, 68105
    - VA Med NWI Endocrine Studies R151
- Nevada
  - Henderson, Nevada, Forenede Stater, 89074
    - Las Vegas Endocrinology
  - Las Vegas, Nevada, Forenede Stater, 89119
    - AB Clinical Trials
  - Las Vegas, Nevada, Forenede Stater, 89121
    - Clinical Research of South Nevada
- New Hampshire
  - Manchester, New Hampshire, Forenede Stater, 03062
    - Catholic Medical Center
- New Jersey
  - Haddon Heights, New Jersey, Forenede Stater, 08035
    - Cooper University Health Care
  - Linden, New Jersey, Forenede Stater, 07036
    - New Jersey Heart
  - Manalapan, New Jersey, Forenede Stater, 07726
    - Garden State Heart Care
  - New Brunswick, New Jersey, Forenede Stater, 08901
    - Robert Wood Johnson Medical School
  - Newark, New Jersey, Forenede Stater, 07112
    - Newark Beth Israel Medical Center
  - Ridgewood, New Jersey, Forenede Stater, 07450
    - The Valley Hospital
  - Somerset, New Jersey, Forenede Stater, 08873
    - Cardio Metabolic Institute
- New Mexico
  - Albuquerque, New Mexico, Forenede Stater, 87102
    - New Mexico Heart Institute
- New York
  - Albany, New York, Forenede Stater, 12206
    - Albany Medical College
  - Binghamton, New York, Forenede Stater, 13901
    - Meridian Clinical Research
  - Cooperstown, New York, Forenede Stater, 13326
    - Bassett Medical Center
  - Endwell, New York, Forenede Stater, 13760
    - Meridian Clinical Research LLC
  - Mineola, New York, Forenede Stater, 11501
    - NYU Langone Hlth Card Assoc
  - New York, New York, Forenede Stater, 10021
    - Weill Cornell Medical Center
  - New York, New York, Forenede Stater, 10029
    - Icahn School of Med at Mt Sinai
  - Northport, New York, Forenede Stater, 11768
    - Northport VA Medical Center
  - Rochester, New York, Forenede Stater, 14609
    - Rochester Clinical Research
  - Stony Brook, New York, Forenede Stater, 11794-3362
    - State Uni of NY at Stony Brook
  - Valhalla, New York, Forenede Stater, 10595
    - Westchester Medical Center
- North Carolina
  - Charlotte, North Carolina, Forenede Stater, 28277
    - Tryon Medical Partners PLLC
  - Charlotte, North Carolina, Forenede Stater, 28204
    - Novant Health Heart Vas Inst
  - Morehead City, North Carolina, Forenede Stater, 28557
    - Lucas Research
  - Raleigh, North Carolina, Forenede Stater, 27607
    - NC Heart and Vascular Research LLC
  - Salisbury, North Carolina, Forenede Stater, 28144
    - Accellacare of Salisbury
  - Winston-Salem, North Carolina, Forenede Stater, 27157
    - Wake Forest University Baptist Medical Center
- North Dakota
  - Grand Forks, North Dakota, Forenede Stater, 58201
    - Altru Health Research Dept.
- Ohio
  - Akron, Ohio, Forenede Stater, 44309
    - Akron Hospital Summa Health System
  - Cincinnati, Ohio, Forenede Stater, 45267
    - University of Cincinnati
  - Cincinnati, Ohio, Forenede Stater, 45246
    - Velocity Clin Research Springdale
  - Cleveland, Ohio, Forenede Stater, 44106-5028
    - Univ Hosp Cleveland Medical Center
  - Dayton, Ohio, Forenede Stater, 45414
    - Premier Cardiovascular Institute
  - Kettering, Ohio, Forenede Stater, 45429
    - Kettering Medical Center
  - Marion, Ohio, Forenede Stater, 43302
    - Rama Research LLC
  - Springfield, Ohio, Forenede Stater, 45504
    - Heart House Research Foundation
  - Toledo, Ohio, Forenede Stater, 43608
    - Mercy Health St Vincent Med Ctr
- Oklahoma
  - Tulsa, Oklahoma, Forenede Stater, 74133
    - Oklahoma Heart Institute
- Oregon
  - Bend, Oregon, Forenede Stater, 97701
    - Bend Memorial Clinic
  - Corvallis, Oregon, Forenede Stater, 97330
    - Samaritan Cardiology
- Pennsylvania
  - Abington, Pennsylvania, Forenede Stater, 19001
    - Abington Memorial Hospital
  - Butler, Pennsylvania, Forenede Stater, 16001
    - Independence Health System Cardiovascular Consultants
  - Pittsburgh, Pennsylvania, Forenede Stater, 15213
    - UPMC
  - Pittsburgh, Pennsylvania, Forenede Stater, 15236
    - Preferred Primary Care Physicians
  - Pittsburgh, Pennsylvania, Forenede Stater, 15243
    - Preferred Primary Care Physicians
  - Smithfield, Pennsylvania, Forenede Stater, 15478
    - Frontier Clinical Research LLC
- Rhode Island
  - Warwick, Rhode Island, Forenede Stater, 02886
    - Kent County Memorial Hospital
- South Carolina
  - Charleston, South Carolina, Forenede Stater, 29425
    - Medical Univ Of South Carolina
  - Columbia, South Carolina, Forenede Stater, 29203
    - Columbia Heart Clinic
  - Columbia, South Carolina, Forenede Stater, 29209
    - Columbia VA Health Care System
  - Greenville, South Carolina, Forenede Stater, 29615
    - Prisma Health Upstate
  - Greenville, South Carolina, Forenede Stater, 29607
    - Bon Secours Medical Group
  - Ladson, South Carolina, Forenede Stater, 29465
    - Trident Cardiology
  - Myrtle Beach, South Carolina, Forenede Stater, 29588
    - Family Medicine of Sayebrook
- South Dakota
  - Sioux Falls, South Dakota, Forenede Stater, 57104
    - Sanford USD Medical Center
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - North Central Heart
- Tennessee
  - Greenville, Tennessee, Forenede Stater, 37745
    - Wellmont CVA Heart Institute
  - Jackson, Tennessee, Forenede Stater, 38301
    - The Jackson Clinic PA
  - Jackson, Tennessee, Forenede Stater, 38301
    - Apex Cardiology Research Associates of Jackson
  - Knoxville, Tennessee, Forenede Stater, 37934
    - Turkey Creek Medical Center
  - Knoxville, Tennessee, Forenede Stater, 37938
    - Accellacare
  - Memphis, Tennessee, Forenede Stater, 38119
    - Memphis Cardiology and Vein Ct
  - Powell, Tennessee, Forenede Stater, 37849
    - Cardiovascular Res of Knoxville LLC
  - Tullahoma, Tennessee, Forenede Stater, 37388
    - Tennessee Center for Clinical Trials
- Texas
  - Amarillo, Texas, Forenede Stater, 79106
    - PharmaTex Research LLC
  - Bedford, Texas, Forenede Stater, 76021
    - North Hills Medical Research Inc
  - Conroe, Texas, Forenede Stater, 77384
    - Javara Research
  - Dallas, Texas, Forenede Stater, 75216
    - VA North Texas Health Care System
  - Dallas, Texas, Forenede Stater, 75231
    - North Texas Endocrine Center
  - Dallas, Texas, Forenede Stater, 75226
    - Soltero Cardiovascular Research Center
  - Dallas, Texas, Forenede Stater, 75231
    - Texas Health Physicians Group
  - Dallas, Texas, Forenede Stater, 75235
    - SW Family Medicine Associates
  - Dallas, Texas, Forenede Stater, 75231
    - Research Institute of Dallas PA
  - Dallas, Texas, Forenede Stater, 78503
    - Alina Clinical Trials
  - El Paso, Texas, Forenede Stater, 79905
    - David Turbay MD PLLC
  - Fort Worth, Texas, Forenede Stater, 76107
    - Texas Health Physicians Group
  - Fort Worth, Texas, Forenede Stater, 76104
    - Texas Health Physicians Group
  - Houston, Texas, Forenede Stater, 77030
    - Houston Methodist Hospital
  - Houston, Texas, Forenede Stater, 77034
    - Orion Medical
  - Houston, Texas, Forenede Stater, 77030
    - UT Physicians Memorial Hermann
  - Houston, Texas, Forenede Stater, 77084
    - Village Medical Village MD S Tx
  - Lampasas, Texas, Forenede Stater, 76550
    - FMC Science
  - Livingston, Texas, Forenede Stater, 77351
    - East Texas Research Associates Inc.
  - McKinney, Texas, Forenede Stater, 75071
    - CardioVoyage LLC
  - Pflugerville, Texas, Forenede Stater, 78660-3015
    - Discovery Clinical Trials
  - Plano, Texas, Forenede Stater, 75075
    - Heartplace-Plano
  - San Antonio, Texas, Forenede Stater, 78240
    - Endeavor Clinical Trials
  - San Antonio, Texas, Forenede Stater, 78229
    - South Texas Cardiovascular Consultants PLLC
  - San Antonio, Texas, Forenede Stater, 78229-3900
    - University of Texas Health Science Ctr
  - Sherman, Texas, Forenede Stater, 75090
    - Sherman Clinical Research
  - Stephenville, Texas, Forenede Stater, 76401
    - Javara Research
  - Sugarland, Texas, Forenede Stater, 77478
    - Privia Medical Group Gulf Coast
- Utah
  - Bountiful, Utah, Forenede Stater, 84010
    - Progressive Clinical Research
- Virginia
  - Burke, Virginia, Forenede Stater, 22015
    - Burke Internal Medicine and Research
  - Forest, Virginia, Forenede Stater, 24551
    - Javara Research
  - Hopewell, Virginia, Forenede Stater, 23860
    - Heart Care Associates P C
  - Norfolk, Virginia, Forenede Stater, 23504
    - York Clinical Research
  - Richmond, Virginia, Forenede Stater, 23219
    - Dominion Medical Associates
  - Roanoke, Virginia, Forenede Stater, 24014
    - Roanoke Heart Institute
  - Winchester, Virginia, Forenede Stater, 22601
    - Winchester Medical Center
- Washington
  - Seattle, Washington, Forenede Stater, 98195
    - University of Washington
  - Seattle, Washington, Forenede Stater, 98101
    - Virginia Mason Medical Centre
  - Seattle, Washington, Forenede Stater, 98122
    - Swedish Medical Center-Cardiovascular Research
  - Tacoma, Washington, Forenede Stater, 98405
    - Universal Research Group LLC
  - Wenatchee, Washington, Forenede Stater, 98801
    - Confluence Health Hospital
Frankrig
- - Amiens, Frankrig, 80054
    - Novartis Investigative Site
  - Brest, Frankrig, 29200
    - Novartis Investigative Site
  - Béziers, Frankrig, 34525
    - Novartis Investigative Site
  - Chambray-lès-Tours, Frankrig, 37170
    - Novartis Investigative Site
  - Cholet, Frankrig, 49325
    - Novartis Investigative Site
  - Clermont-Ferrand, Frankrig, 63003
    - Novartis Investigative Site
  - Corbeil-Essonnes, Frankrig, 91100
    - Novartis Investigative Site
  - Grenoble, Frankrig, 38043
    - Novartis Investigative Site
  - Le Coudray, Frankrig, 28630
    - Novartis Investigative Site
  - Lille, Frankrig, 59000
    - Novartis Investigative Site
  - Lyon, Frankrig, 69007
    - Novartis Investigative Site
  - Marseille, Frankrig, 13885
    - Novartis Investigative Site
  - Metz, Frankrig, 57085
    - Novartis Investigative Site
  - Montauban, Frankrig, 82017
    - Novartis Investigative Site
  - Montpellier, Frankrig, 34295
    - Novartis Investigative Site
  - Nice, Frankrig, 06000
    - Novartis Investigative Site
  - Nîmes, Frankrig, 30029
    - Novartis Investigative Site
  - Orléans, Frankrig, 45100
    - Novartis Investigative Site
  - Paris, Frankrig, 75013
    - Novartis Investigative Site
  - Paris, Frankrig, 75015
    - Novartis Investigative Site
  - Paris, Frankrig, 75010
    - Novartis Investigative Site
  - Paris, Frankrig, 75018
    - Novartis Investigative Site
  - Pau, Frankrig, 64046
    - Novartis Investigative Site
  - Pessac, Frankrig, 33604
    - Novartis Investigative Site
  - Poitiers, Frankrig, 86021
    - Novartis Investigative Site
  - Reims, Frankrig, 51092
    - Novartis Investigative Site
  - Rennes, Frankrig, 35033
    - Novartis Investigative Site
  - Toulouse, Frankrig, 31054
    - Novartis Investigative Site
  - Tourcoing, Frankrig, 59208
    - Novartis Investigative Site
  - Valenciennes, Frankrig, 59300
    - Novartis Investigative Site
  - Villeneuve-d'Ascq, Frankrig, 59650
    - Novartis Investigative Site
- Haute Vienne
  - Limoges, Haute Vienne, Frankrig, 87000
    - Novartis Investigative Site
Grækenland
- - Athens, Grækenland, 115 27
    - Novartis Investigative Site
  - Athens, Grækenland, 115 21
    - Novartis Investigative Site
  - Athens, Grækenland, 11528
    - Novartis Investigative Site
  - Ioannina, Grækenland, 455 00
    - Novartis Investigative Site
  - Larissa, Grækenland, 411 10
    - Novartis Investigative Site
  - Thessaloniki, Grækenland, 54636
    - Novartis Investigative Site
  - Thessaloniki, Grækenland, 570 01
    - Novartis Investigative Site
Holland
- - Amersfoort, Holland, 3813 TZ
    - Novartis Investigative Site
  - Gouda, Holland, 2803 HH
    - Novartis Investigative Site
  - Venlo, Holland, 5912 BL
    - Novartis Investigative Site
- Drenthe
  - Meppel, Drenthe, Holland, 7943 KC
    - Novartis Investigative Site
- Gelderland
  - Doetinchem, Gelderland, Holland, 7009 BL
    - Novartis Investigative Site
  - Nijmegen, Gelderland, Holland, 6500HB
    - Novartis Investigative Site
  - Tiel, Gelderland, Holland, 4002 WP
    - Novartis Investigative Site
- Gerlderland
  - Nijmegen, Gerlderland, Holland, 6532 SZ
    - Novartis Investigative Site
- North Brabant
  - Breda, North Brabant, Holland, 4818 CK
    - Novartis Investigative Site
  - Tilburg, North Brabant, Holland, 5042 AD
    - Novartis Investigative Site
- North Holland
  - Alkmaar, North Holland, Holland, 1815 JD
    - Novartis Investigative Site
  - Amstelveen, North Holland, Holland, 1186 AM
    - Novartis Investigative Site
  - Amsterdam, North Holland, Holland, 1090 HM
    - Novartis Investigative Site
  - Amsterdam, North Holland, Holland, 1105 AZ
    - Novartis Investigative Site
  - Heemstede, North Holland, Holland, 2035 RC
    - Novartis Investigative Site
- Overijssel
  - Deventer, Overijssel, Holland, 7416 SE
    - Novartis Investigative Site
- Provincie Friesland
  - Leeuwarden, Provincie Friesland, Holland, 8934 AD
    - Novartis Investigative Site
  - Sneek, Provincie Friesland, Holland, 8601 ZK
    - Novartis Investigative Site
- Provincie Groningen
  - Groningen, Provincie Groningen, Holland, 9713 GZ
    - Novartis Investigative Site
  - Groningen, Provincie Groningen, Holland, 9728 NZ
    - Novartis Investigative Site
- South Holland
  - Leiden, South Holland, Holland, 2333 ZA
    - Novartis Investigative Site
  - Leiderdorp, South Holland, Holland, 2353 GA
    - Novartis Investigative Site
Indien
- - New Delhi, Indien, 110025
    - Novartis Investigative Site
  - Puducherry, Indien, 607402
    - Novartis Investigative Site
  - Uttarakhand, Indien, 263153
    - Novartis Investigative Site
- Andhra Pradesh
  - Guntur, Andhra Pradesh, Indien, 522001
    - Novartis Investigative Site
  - Hyderabad, Andhra Pradesh, Indien, 500033
    - Novartis Investigative Site
- Gujarat
  - Ahmedabad, Gujarat, Indien, 382428
    - Novartis Investigative Site
  - Ahmedabad, Gujarat, Indien, 380054
    - Novartis Investigative Site
  - Ahmedabad, Gujarat, Indien, 380060
    - Novartis Investigative Site
  - Vadodara, Gujarat, Indien, 390022
    - Novartis Investigative Site
- Karnataka
  - Belagavi, Karnataka, Indien, 590010
    - Novartis Investigative Site
  - Manipal, Karnataka, Indien, 576104
    - Novartis Investigative Site
  - Mysore, Karnataka, Indien, 570001
    - Novartis Investigative Site
  - Mysore, Karnataka, Indien, 570015
    - Novartis Investigative Site
- Kerala
  - Kochi, Kerala, Indien, 682041
    - Novartis Investigative Site
  - Kochi, Kerala, Indien, 682018
    - Novartis Investigative Site
  - Kozhikode, Kerala, Indien, 673008
    - Novartis Investigative Site
- Madhyapradesh
  - Indore, Madhyapradesh, Indien, 452003
    - Novartis Investigative Site
- Maharashtra
  - Mumbai, Maharashtra, Indien, 400012
    - Novartis Investigative Site
  - Nagpur, Maharashtra, Indien, 440012
    - Novartis Investigative Site
  - Nagpur, Maharashtra, Indien, 440033
    - Novartis Investigative Site
  - Nashik, Maharashtra, Indien, 422005
    - Novartis Investigative Site
  - Pune, Maharashtra, Indien, 411004
    - Novartis Investigative Site
  - Pune, Maharashtra, Indien, 411045
    - Novartis Investigative Site
- National Capital Territory of Delhi
  - New Delhi, National Capital Territory of Delhi, Indien, 110060
    - Novartis Investigative Site
  - New Delhi, National Capital Territory of Delhi, Indien, 110076
    - Novartis Investigative Site
  - New Delhi, National Capital Territory of Delhi, Indien, 110075
    - Novartis Investigative Site
- Rajasthan
  - Bikaner, Rajasthan, Indien, 334003
    - Novartis Investigative Site
- Tamil Nadu
  - Chennai, Tamil Nadu, Indien, 600006
    - Novartis Investigative Site
  - Coimbatore, Tamil Nadu, Indien, 641037
    - Novartis Investigative Site
  - Coimbatore, Tamil Nadu, Indien, 641009
    - Novartis Investigative Site
  - Madurai, Tamil Nadu, Indien, 625020
    - Novartis Investigative Site
- Telangana
  - Hyderabad, Telangana, Indien, 500034
    - Novartis Investigative Site
  - Secunderabad, Telangana, Indien, 500003
    - Novartis Investigative Site
- Uttar Pradesh
  - Aligarh, Uttar Pradesh, Indien, 202002
    - Novartis Investigative Site
  - Ghaziabad, Uttar Pradesh, Indien, 201012
    - Novartis Investigative Site
  - Kanpur, Uttar Pradesh, Indien, 208002
    - Novartis Investigative Site
  - Lucknow, Uttar Pradesh, Indien, 226003
    - Novartis Investigative Site
  - Varanasi, Uttar Pradesh, Indien, 221010
    - Novartis Investigative Site
- Uttarakhand
  - Dehradun, Uttarakhand, Indien, 248001
    - Novartis Investigative Site
- Uttrakhand
  - Dehradun, Uttrakhand, Indien, 248104
    - Novartis Investigative Site
- West Bengal
  - Kolkata, West Bengal, Indien, 700054
    - Novartis Investigative Site
Island
- - Kopavogur, Island, 201
    - Novartis Investigative Site
  - Reykjavik, Island, 101
    - Novartis Investigative Site
Israel
- - Ashdod, Israel, 7747629
    - Novartis Investigative Site
  - Holon, Israel, 5822012
    - Novartis Investigative Site
  - Jerusalem, Israel, 9112001
    - Novartis Investigative Site
  - Nahariya, Israel, 2210001
    - Novartis Investigative Site
  - Petah Tikva, Israel, 4941492
    - Novartis Investigative Site
  - Ramat Gan, Israel, 5265601
    - Novartis Investigative Site
  - Sefad, Israel, 1311300
    - Novartis Investigative Site
  - Ẕerifin, Israel, 7030000
    - Novartis Investigative Site
Italien
- BO
  - Bologna, BO, Italien, 40138
    - Novartis Investigative Site
  - Bologna, BO, Italien, 40133
    - Novartis Investigative Site
- BS
  - Brescia, BS, Italien, 25123
    - Novartis Investigative Site
- FE
  - Cona, FE, Italien, 44124
    - Novartis Investigative Site
- FI
  - Florence, FI, Italien, 50134
    - Novartis Investigative Site
- GR
  - Grosseto, GR, Italien, 58100
    - Novartis Investigative Site
- IS
  - Pozzilli, IS, Italien, 86077
    - Novartis Investigative Site
- MI
  - Milan, MI, Italien, 20162
    - Novartis Investigative Site
  - Milan, MI, Italien, 20132
    - Novartis Investigative Site
  - Milan, MI, Italien, 20138
    - Novartis Investigative Site
  - Rozzano, MI, Italien, 20089
    - Novartis Investigative Site
- MO
  - Modena, MO, Italien, 41126
    - Novartis Investigative Site
- PN
  - Pordenone, PN, Italien, 33170
    - Novartis Investigative Site
- SI
  - Siena, SI, Italien, 53100
    - Novartis Investigative Site
- SS
  - Sassari, SS, Italien, 07100
    - Novartis Investigative Site
- TO
  - Torino, TO, Italien, 10126
    - Novartis Investigative Site
Japan
- Aichi-ken
  - Toyota, Aichi-ken, Japan, 471-8513
    - Novartis Investigative Site
- Fukuka
  - Chikushino-shi, Fukuka, Japan, 818-8516
    - Novartis Investigative Site
- Ishikawa-ken
  - Kanazawa, Ishikawa-ken, Japan, 9208650
    - Novartis Investigative Site
  - Komatsu, Ishikawa-ken, Japan, 923-0961
    - Novartis Investigative Site
- Kanagawa
  - Fujisawa, Kanagawa, Japan, 2518550
    - Novartis Investigative Site
  - Odawara, Kanagawa, Japan, 2508558
    - Novartis Investigative Site
  - Yokohama, Kanagawa, Japan, 247-8581
    - Novartis Investigative Site
- Nagasaki
  - Nagasaki, Nagasaki, Japan, 8508555
    - Novartis Investigative Site
- Niigata
  - Nagaoka, Niigata, Japan, 940-8621
    - Novartis Investigative Site
- Osaka
  - Izumisano, Osaka, Japan, 5988577
    - Novartis Investigative Site
  - Osaka, Osaka, Japan, 5400006
    - Novartis Investigative Site
- Saitama
  - Kawaguchi, Saitama, Japan, 332-8558
    - Novartis Investigative Site
Kenya
- - Nairobi, Kenya, 00200
    - Novartis Investigative Site
Kina
- - Beijing, Kina, 100029
    - Novartis Investigative Site
  - Beijing, Kina, 100034
    - Novartis Investigative Site
  - Beijing, Kina, 100050
    - Novartis Investigative Site
  - Beijing, Kina, 100191
    - Novartis Investigative Site
  - Beijing, Kina, 100039
    - Novartis Investigative Site
  - Chongqing, Kina, 400016
    - Novartis Investigative Site
  - Guangzhou, Kina, 510280
    - Novartis Investigative Site
  - Jinan, Kina, 250012
    - Novartis Investigative Site
  - Shanghai, Kina, 200080
    - Novartis Investigative Site
  - Shanghai, Kina, 200032
    - Novartis Investigative Site
  - Shanghai, Kina, 200025
    - Novartis Investigative Site
  - Shanghai, Kina, 200040
    - Novartis Investigative Site
  - Tianjin, Kina, 300140
    - Novartis Investigative Site
  - Xiamen, Kina, 361004
    - Novartis Investigative Site
- Beijing Municipality
  - Beijing, Beijing Municipality, Kina, 100013
    - Novartis Investigative Site
- Guangdong
  - Foshan, Guangdong, Kina, 528000
    - Novartis Investigative Site
  - Guangzhou, Guangdong, Kina, 510080
    - Novartis Investigative Site
  - Guangzhou, Guangdong, Kina, 510030
    - Novartis Investigative Site
  - Guangzhou, Guangdong, Kina, 510000
    - Novartis Investigative Site
  - Guangzhou, Guangdong, Kina, 510515
    - Novartis Investigative Site
- Guangxi
  - Nanning, Guangxi, Kina, 530022
    - Novartis Investigative Site
- Heilongjiang
  - Harbin, Heilongjiang, Kina, 150000
    - Novartis Investigative Site
- Hubei
  - Jingzhou, Hubei, Kina, 434020
    - Novartis Investigative Site
  - Wuhan, Hubei, Kina, 430060
    - Novartis Investigative Site
  - Wuhan, Hubei, Kina, 430022
    - Novartis Investigative Site
  - Wuhan, Hubei, Kina, 430014
    - Novartis Investigative Site
- Hunan
  - Changsha, Hunan, Kina, 410011
    - Novartis Investigative Site
  - Changsha, Hunan, Kina, 410003
    - Novartis Investigative Site
- Inner Mongolia
  - Hohhot, Inner Mongolia, Kina, 010017
    - Novartis Investigative Site
- Jiangsu
  - Changzhou, Jiangsu, Kina, 213004
    - Novartis Investigative Site
  - Jiangyin, Jiangsu, Kina, 214499
    - Novartis Investigative Site
  - Nanjing, Jiangsu, Kina, 210008
    - Novartis Investigative Site
  - Nanjing, Jiangsu, Kina, 210009
    - Novartis Investigative Site
  - Nanjing, Jiangsu, Kina, 211166
    - Novartis Investigative Site
  - Suzhou, Jiangsu, Kina, 215004
    - Novartis Investigative Site
  - Xuzhou, Jiangsu, Kina, 221003
    - Novartis Investigative Site
- Jiangxi
  - Nanchang, Jiangxi, Kina, 330006
    - Novartis Investigative Site
  - Pingxiang, Jiangxi, Kina, 337000
    - Novartis Investigative Site
- Jilin
  - Changchun, Jilin, Kina, 130000
    - Novartis Investigative Site
- Liaoning
  - Dalian, Liaoning, Kina, 116011
    - Novartis Investigative Site
  - Shenyang, Liaoning, Kina, 110004
    - Novartis Investigative Site
- Shandong
  - Jinan, Shandong, Kina, 250013
    - Novartis Investigative Site
- Shanxi
  - Taiyuan, Shanxi, Kina, 030002
    - Novartis Investigative Site
  - Xian, Shanxi, Kina, 710061
    - Novartis Investigative Site
- Sichuan
  - Chengdu, Sichuan, Kina, 610041
    - Novartis Investigative Site
- Tianjin Municipality
  - Tianjin, Tianjin Municipality, Kina, 300121
    - Novartis Investigative Site
- Xinjiang
  - Ürümqi, Xinjiang, Kina, 830001
    - Novartis Investigative Site
  - Ürümqi, Xinjiang, Kina, 830054
    - Novartis Investigative Site
- Zhejiang
  - Hangzhou, Zhejiang, Kina, 310016
    - Novartis Investigative Site
  - Lishui, Zhejiang, Kina, 323000
    - Novartis Investigative Site
  - Taizhou, Zhejiang, Kina, 318000
    - Novartis Investigative Site
Kroatien
- - Opatija, Kroatien, 51410
    - Novartis Investigative Site
  - Osijek, Kroatien, 31000
    - Novartis Investigative Site
  - Rijeka, Kroatien, 51000
    - Novartis Investigative Site
  - Split, Kroatien, 21000
    - Novartis Investigative Site
  - Zagreb, Kroatien, 10000
    - Novartis Investigative Site
  - Čakovec, Kroatien, 40000
    - Novartis Investigative Site
- Croatia
  - Krapinske Toplice, Croatia, Kroatien, 49 217
    - Novartis Investigative Site
  - Slavonski Brod, Croatia, Kroatien, 35000
    - Novartis Investigative Site
  - Zagreb, Croatia, Kroatien, 10000
    - Novartis Investigative Site
Letland
- - Daugavpils, Letland, LV-5417
    - Novartis Investigative Site
  - Kuldīga, Letland, LV-3300
    - Novartis Investigative Site
  - Riga, Letland, LV 1002
    - Novartis Investigative Site
  - Riga, Letland, 1012
    - Novartis Investigative Site
  - Riga, Letland, LV-1001
    - Novartis Investigative Site
  - Valmiera, Letland, 4201
    - Novartis Investigative Site
- LV
  - Liepāja, LV, Letland, LV-3414
    - Novartis Investigative Site
  - Riga, LV, Letland, 1038
    - Novartis Investigative Site
Litauen
- - Kaunas, Litauen, LT-50009
    - Novartis Investigative Site
  - Kaunas, Litauen, 49449
    - Novartis Investigative Site
  - Panevezys, Litauen, 35144
    - Novartis Investigative Site
  - Vilnius, Litauen, LT-08406
    - Novartis Investigative Site
  - Šiauliai, Litauen, 76206
    - Novartis Investigative Site
- Kaunas County
  - Kaunas, Kaunas County, Litauen, LT-50177
    - Novartis Investigative Site
- Klaipėda County
  - Klaipėda, Klaipėda County, Litauen, 92288
    - Novartis Investigative Site
- LTU
  - Kaunas, LTU, Litauen, LT 50161
    - Novartis Investigative Site
  - Šiauliai, LTU, Litauen, LT-77156
    - Novartis Investigative Site
Malaysia
- - Kuala Lumpur, Malaysia, 59100
    - Novartis Investigative Site
  - Kuala Lumpur, Malaysia, 56000
    - Novartis Investigative Site
- Kedah
  - Alor Star, Kedah, Malaysia, 05460
    - Novartis Investigative Site
- Pahang
  - Kuantan, Pahang, Malaysia, 25100
    - Novartis Investigative Site
- Perak
  - Ipoh, Perak, Malaysia, 30450
    - Novartis Investigative Site
- Selangor
  - Kuala Lumpur, Selangor, Malaysia, 43000
    - Novartis Investigative Site
Mauritius
- - Phoenix, Mauritius, 73408
    - Novartis Investigative Site
- Mauritius
  - Solferino Phoenix, Mauritius, Mauritius, 1772
    - Novartis Investigative Site
Mexico
- - Acapulco, Mexico, 39570
    - Novartis Investigative Site
  - Aguascalientes, Mexico, 20230
    - Novartis Investigative Site
  - Durango, Mexico, 34000
    - Novartis Investigative Site
  - Guadalajara, Mexico, 44360
    - Novartis Investigative Site
  - Xalapa, Mexico, 91020
    - Novartis Investigative Site
  - Xalapa, Mexico, 91193
    - Novartis Investigative Site
- Aguascalientes
  - Aguascalientes, Aguascalientes, Mexico, 20230
    - Novartis Investigative Site
- Chihuahua
  - Chihuahua City, Chihuahua, Mexico, 31203
    - Novartis Investigative Site
- Jalisco
  - Guadalajara, Jalisco, Mexico, 44670
    - Novartis Investigative Site
  - Guadalajara, Jalisco, Mexico, 44600
    - Novartis Investigative Site
  - Guadalajara, Jalisco, Mexico, 44210
    - Novartis Investigative Site
- Mexico City
  - Mexico City, Mexico City, Mexico, 06700
    - Novartis Investigative Site
- Nuevo León
  - Monterrey, Nuevo León, Mexico, 64710
    - Novartis Investigative Site
- State of Mexico
  - Tlalnepantla, State of Mexico, Mexico, 54055
    - Novartis Investigative Site
- Yucatán
  - Mérida, Yucatán, Mexico, 97070
    - Novartis Investigative Site
New Zealand
- - Auckland, New Zealand, 740
    - Novartis Investigative Site
  - Christchurch, New Zealand, 8140
    - Novartis Investigative Site
  - Hamilton, New Zealand, 3240
    - Novartis Investigative Site
  - Lower Hutt, New Zealand, 5040
    - Novartis Investigative Site
- Auckland
  - Grafton, Auckland, New Zealand, 1023
    - Novartis Investigative Site
- Christchurch
  - Christchurch, Christchurch, New Zealand, 8001
    - Novartis Investigative Site
- NZW
  - Dunedin, NZW, New Zealand, 9016
    - Novartis Investigative Site
Norge
- - Arendal, Norge, 4838
    - Novartis Investigative Site
  - Drammen, Norge, 3004
    - Novartis Investigative Site
  - Oslo, Norge, 0514
    - Novartis Investigative Site
  - Oslo, Norge, NO-0407
    - Novartis Investigative Site
  - Skedsmokorset, Norge, 2020
    - Novartis Investigative Site
  - Tromsø, Norge, 9038
    - Novartis Investigative Site
- Oslo
  - Nordbyhagen, Oslo, Norge, 1478
    - Novartis Investigative Site
- Stavanger
  - Stavanger, Stavanger, Norge, 4019
    - Novartis Investigative Site
Polen
- - Bialystok, Polen, 15-540
    - Novartis Investigative Site
  - Bialystok, Polen, 15-481
    - Novartis Investigative Site
  - Bydgoszcz, Polen, 85-065
    - Novartis Investigative Site
  - Gdynia, Polen, 81-423
    - Novartis Investigative Site
  - Kielce, Polen, 25-525
    - Novartis Investigative Site
  - Krakow, Polen, 31-501
    - Novartis Investigative Site
  - Krakow, Polen, 30-082
    - Novartis Investigative Site
  - Krakow, Polen, 30-363
    - Novartis Investigative Site
  - Kłodzko, Polen, 57-300
    - Novartis Investigative Site
  - Lodz, Polen, 93-513
    - Novartis Investigative Site
  - Lublin, Polen, 20-068
    - Novartis Investigative Site
  - Olsztyn, Polen, 10-165
    - Novartis Investigative Site
  - Ostrowiec Swietok, Polen, 27-400
    - Novartis Investigative Site
  - Puławy, Polen, 24-100
    - Novartis Investigative Site
  - Ruda Śląska, Polen, 41-710
    - Novartis Investigative Site
  - Skierniewice, Polen, 96-100
    - Novartis Investigative Site
  - Torun, Polen, 87-100
    - Novartis Investigative Site
  - Warsaw, Polen, 00-416
    - Novartis Investigative Site
  - Warsaw, Polen, 01 813
    - Novartis Investigative Site
  - Warsaw, Polen, 04-073
    - Novartis Investigative Site
  - Włocławek, Polen, 87-800
    - Novartis Investigative Site
  - Zamość, Polen, 22-400
    - Novartis Investigative Site
- Lesser Poland Voivodeship
  - Nowy Targ, Lesser Poland Voivodeship, Polen, 34-400
    - Novartis Investigative Site
- Masovian Voivodeship
  - Ostrołęka, Masovian Voivodeship, Polen, 07-410
    - Novartis Investigative Site
- Silesian Voivodeship
  - Sosnowiec, Silesian Voivodeship, Polen, 41-219
    - Novartis Investigative Site
Portugal
- - Alcabideche, Portugal, 2755-009
    - Novartis Investigative Site
  - Almada, Portugal, 2805-267
    - Novartis Investigative Site
  - Carnaxide, Portugal, 2799-523
    - Novartis Investigative Site
  - Coimbra, Portugal, 3004-561
    - Novartis Investigative Site
  - Guimarães, Portugal, 4835-044
    - Novartis Investigative Site
  - Leiria, Portugal, 2410-197
    - Novartis Investigative Site
  - Lisbon, Portugal, 1500 650
    - Novartis Investigative Site
  - Lisbon, Portugal, 1649-035
    - Novartis Investigative Site
  - Matosinhos Municipality, Portugal, 4454-513
    - Novartis Investigative Site
  - Santa Maria da Feira, Portugal, 4520-211
    - Novartis Investigative Site
  - Vila Nova de Gaia, Portugal, 4434 502
    - Novartis Investigative Site
  - Vila Real, Portugal, 5000-508
    - Novartis Investigative Site
Puerto Rico
- - Bayamón, Puerto Rico, 00959
    - Advanced Clinical Research LLC
  - Ponce, Puerto Rico, 00717-1322
    - Research and Cardiovascular Corp
  - San Juan, Puerto Rico, 00926
    - Advance Medical Research Center
  - San Juan, Puerto Rico, 00909
    - Latin Clinical Trial Center Inc
  - San Juan, Puerto Rico, 00926
    - Barbara Diaz Hernandez Research Inc
Rumænien
- - Brasov, Rumænien, 500283
    - Novartis Investigative Site
  - Bucharest, Rumænien, 022328
    - Novartis Investigative Site
  - Bucharest, Rumænien, 050098
    - Novartis Investigative Site
  - Bucharest, Rumænien, 021659
    - Novartis Investigative Site
  - Bucharest, Rumænien, 011461
    - Novartis Investigative Site
  - Bucharest, Rumænien, 011025
    - Novartis Investigative Site
  - Caracal, Rumænien, 235200
    - Novartis Investigative Site
  - Craiova, Rumænien, 200642
    - Novartis Investigative Site
  - Iași, Rumænien, 700503
    - Novartis Investigative Site
  - Timișoara, Rumænien, 300079
    - Novartis Investigative Site
  - Timișoara, Rumænien, 300359
    - Novartis Investigative Site
  - Târgu Mureş, Rumænien, 540143
    - Novartis Investigative Site
- Argeş
  - Piteşti, Argeş, Rumænien, 110424
    - Novartis Investigative Site
- Maramureş
  - Baia Mare, Maramureş, Rumænien, 430123
    - Novartis Investigative Site
- Mureș County
  - Târgu Mureş, Mureș County, Rumænien, 540124
    - Novartis Investigative Site
- Oradea
  - Oradea, Oradea, Rumænien, 410169
    - Novartis Investigative Site
- ROM
  - Brăila, ROM, Rumænien, 810249
    - Novartis Investigative Site
- Timiș County
  - Timișoara, Timiș County, Rumænien, 300041
    - Novartis Investigative Site
  - Timișoara, Timiș County, Rumænien, 300480
    - Novartis Investigative Site
Rusland
- - Moscow, Rusland, 127473
    - Novartis Investigative Site
  - Ryazan, Rusland, 390039
    - Novartis Investigative Site
  - Saint Petersburg, Rusland, 195197
    - Novartis Investigative Site
  - Yaroslavl, Rusland, 150062
    - Novartis Investigative Site
Serbien
- - Belgrade, Serbien, 11000
    - Novartis Investigative Site
  - Kragujevac, Serbien, 34000
    - Novartis Investigative Site
  - Leskovac, Serbien, 16000
    - Novartis Investigative Site
  - Niš, Serbien, 18000
    - Novartis Investigative Site
  - Smederevo, Serbien, 26000
    - Novartis Investigative Site
  - Subotica, Serbien, 24000
    - Novartis Investigative Site
  - Vranje, Serbien, 17500
    - Novartis Investigative Site
  - Zaječar, Serbien, 19000
    - Novartis Investigative Site
  - Ćuprija, Serbien, 35230
    - Novartis Investigative Site
- Serbia
  - Belgrade, Serbia, Serbien, 11000
    - Novartis Investigative Site
  - Belgrade, Serbia, Serbien, 11080
    - Novartis Investigative Site
  - Kamenitz, Serbia, Serbien, 21204
    - Novartis Investigative Site
Singapore
- - Singapore, Singapore, 119074
    - Novartis Investigative Site
  - Singapore, Singapore, 529889
    - Novartis Investigative Site
  - Singapore, Singapore, 169609
    - Novartis Investigative Site
- Singapore
  - Singapore, Singapore, Singapore, 768828
    - Novartis Investigative Site
Slovakiet
- - Banská Bystrica, Slovakiet, 974 01
    - Novartis Investigative Site
  - Bardejov, Slovakiet, 085 01
    - Novartis Investigative Site
  - Bratislava, Slovakiet, 831 06
    - Novartis Investigative Site
  - Bratislava, Slovakiet, 833 48
    - Novartis Investigative Site
  - Bratislava, Slovakiet, 851 01
    - Novartis Investigative Site
  - Bratislava, Slovakiet, 841 08
    - Novartis Investigative Site
  - Košice, Slovakiet, 040 01
    - Novartis Investigative Site
  - Košice, Slovakiet, 040 22
    - Novartis Investigative Site
  - Lučenec, Slovakiet, 984 01
    - Novartis Investigative Site
  - Moldava nad Bodvou, Slovakiet, 045 01
    - Novartis Investigative Site
  - Nitra, Slovakiet, 949 01
    - Novartis Investigative Site
  - Nitra, Slovakiet, 949 11
    - Novartis Investigative Site
  - Nové Zámky, Slovakiet, 940 01
    - Novartis Investigative Site
  - Piešťany, Slovakiet, 921 01
    - Novartis Investigative Site
  - Považská Bystrica, Slovakiet, 017 01
    - Novartis Investigative Site
  - Prešov, Slovakiet, 080 01
    - Novartis Investigative Site
  - Rožňava, Slovakiet, 048 01
    - Novartis Investigative Site
  - Žilina, Slovakiet, 010 01
    - Novartis Investigative Site
- Slovakia
  - Bratislava, Slovakia, Slovakiet, 813 69
    - Novartis Investigative Site
  - Bratislava, Slovakia, Slovakiet, 826 06
    - Novartis Investigative Site
  - Košice, Slovakia, Slovakiet, 040 01
    - Novartis Investigative Site
Slovenien
- - Celje, Slovenien, 3000
    - Novartis Investigative Site
  - Ljubljana, Slovenien, 1000
    - Novartis Investigative Site
  - Ptuj, Slovenien, 2250
    - Novartis Investigative Site
  - Slovenj Gradec, Slovenien, 2380
    - Novartis Investigative Site
Spanien
- - A Coruña, Spanien, 15006
    - Novartis Investigative Site
  - A Coruña, Spanien, 15001
    - Novartis Investigative Site
  - Alicante, Spanien, 03700
    - Novartis Investigative Site
  - Almería, Spanien, 04009
    - Novartis Investigative Site
  - Barcelona, Spanien, 08035
    - Novartis Investigative Site
  - Barcelona, Spanien, 08036
    - Novartis Investigative Site
  - Barcelona, Spanien, 08041
    - Novartis Investigative Site
  - Barcelona, Spanien, 08025
    - Novartis Investigative Site
  - Barcelona, Spanien, 08023
    - Novartis Investigative Site
  - Córdoba, Spanien, 14004
    - Novartis Investigative Site
  - Granada, Spanien, 18016
    - Novartis Investigative Site
  - Huelva, Spanien, 21080
    - Novartis Investigative Site
  - Las Palmas GC, Spanien, 35010
    - Novartis Investigative Site
  - Madrid, Spanien, 28041
    - Novartis Investigative Site
  - Madrid, Spanien, 28034
    - Novartis Investigative Site
  - Madrid, Spanien, 28046
    - Novartis Investigative Site
  - Madrid, Spanien, 28006
    - Novartis Investigative Site
  - Madrid, Spanien, 28040
    - Novartis Investigative Site
  - Madrid, Spanien, 28009
    - Novartis Investigative Site
  - Madrid, Spanien, 28003
    - Novartis Investigative Site
  - Málaga, Spanien, 29010
    - Novartis Investigative Site
  - Salamanca, Spanien, 37007
    - Novartis Investigative Site
  - Salamanca, Spanien, 37005
    - Novartis Investigative Site
  - Seville, Spanien, 41009
    - Novartis Investigative Site
  - Seville, Spanien, 41013
    - Novartis Investigative Site
  - Valencia, Spanien, 46014
    - Novartis Investigative Site
  - Valencia, Spanien, 46010
    - Novartis Investigative Site
  - Valladolid, Spanien, 47011
    - Novartis Investigative Site
  - Zaragoza, Spanien, 50009
    - Novartis Investigative Site
- A Coruna
  - Ferrol, A Coruna, Spanien, 15405
    - Novartis Investigative Site
  - Santiago Compostela, A Coruna, Spanien, 15706
    - Novartis Investigative Site
- Andalusia
  - Seville, Andalusia, Spanien, 41014
    - Novartis Investigative Site
- Balearic Islands
  - Mallorca, Balearic Islands, Spanien, 07198
    - Novartis Investigative Site
  - Palma, Balearic Islands, Spanien, 07120
    - Novartis Investigative Site
- Barcelona
  - L'Hospitalet de Llobregat, Barcelona, Spanien, 08907
    - Novartis Investigative Site
  - Sabadell, Barcelona, Spanien, 08208
    - Novartis Investigative Site
  - Sant Joan Despí, Barcelona, Spanien, 08970
    - Novartis Investigative Site
  - el Prat de Llobregat, Barcelona, Spanien, 08820
    - Novartis Investigative Site
- Bizkaia
  - Bilbao, Bizkaia, Spanien, 48013
    - Novartis Investigative Site
- Cadiz
  - Jerez de la Frontera, Cadiz, Spanien, 11407
    - Novartis Investigative Site
  - Villamartín, Cadiz, Spanien, 11650
    - Novartis Investigative Site
- Cantabria
  - Santander, Cantabria, Spanien, 39008
    - Novartis Investigative Site
- Madrid
  - Alcorcón, Madrid, Spanien, 28922
    - Novartis Investigative Site
  - San Sebastian Reyes, Madrid, Spanien, 28702
    - Novartis Investigative Site
- Murcia
  - El Palmar, Murcia, Spanien, 30120
    - Novartis Investigative Site
- Pontevedra
  - Vigo, Pontevedra, Spanien, 36212
    - Novartis Investigative Site
- Sevilla
  - Utrera, Sevilla, Spanien, 41710
    - Novartis Investigative Site
- Tarragona
  - Reus, Tarragona, Spanien, 43201
    - Novartis Investigative Site
Sverige
- - Falun, Sverige, 791 82
    - Novartis Investigative Site
  - Gothenburg, Sverige, SE-412 55
    - Novartis Investigative Site
  - Lund, Sverige, 221 85
    - Novartis Investigative Site
  - Malmö, Sverige, 214 28
    - Novartis Investigative Site
  - Stockholm, Sverige, 111 57
    - Novartis Investigative Site
  - Stockholm, Sverige, 17176
    - Novartis Investigative Site
  - Västerås, Sverige, 721 89
    - Novartis Investigative Site
- SE
  - Stockholm, SE, Sverige, 141 86
    - Novartis Investigative Site
- Västra Götaland County
  - Gothenburg, Västra Götaland County, Sverige, 416 85
    - Novartis Investigative Site
Sydafrika
- - Bloemfontein, Sydafrika, 9301
    - Novartis Investigative Site
  - Cape Town, Sydafrika, 7500
    - Novartis Investigative Site
  - Midrand, Sydafrika, 1685
    - Novartis Investigative Site
  - Pretoria, Sydafrika, 0181
    - Novartis Investigative Site
- Centurion
  - Raslouw, Centurion, Sydafrika, 0157
    - Novartis Investigative Site
- Free State
  - Bloemfontein, Free State, Sydafrika, 9301
    - Novartis Investigative Site
- Gauteng
  - Germiston, Gauteng, Sydafrika, 1401
    - Novartis Investigative Site
  - Pretoria, Gauteng, Sydafrika, 0184
    - Novartis Investigative Site
  - Pretoria, Gauteng, Sydafrika, 0002
    - Novartis Investigative Site
  - Soweto, Gauteng, Sydafrika, 2013
    - Novartis Investigative Site
  - Vereeniging, Gauteng, Sydafrika, 1939
    - Novartis Investigative Site
- Western Cape
  - Cape Town, Western Cape, Sydafrika, 7530
    - Novartis Investigative Site
  - Cape Town, Western Cape, Sydafrika, 7130
    - Novartis Investigative Site
  - George, Western Cape, Sydafrika, 6529
    - Novartis Investigative Site
  - Paarl, Western Cape, Sydafrika, 7626
    - Novartis Investigative Site
  - Somerset West, Western Cape, Sydafrika, 7130
    - Novartis Investigative Site
  - Worcester, Western Cape, Sydafrika, 6850
    - Novartis Investigative Site
- ZAF
  - Cape Town, ZAF, Sydafrika, 7570
    - Novartis Investigative Site
Sydkorea
- - Busan, Sydkorea, 49201
    - Novartis Investigative Site
  - Daegu, Sydkorea, 705703
    - Novartis Investigative Site
  - Daejeon, Sydkorea, 302-241
    - Novartis Investigative Site
  - Gwangju, Sydkorea, 61469
    - Novartis Investigative Site
  - Seoul, Sydkorea, 03722
    - Novartis Investigative Site
  - Seoul, Sydkorea, 06591
    - Novartis Investigative Site
- Dalseo gu
  - Daegu, Dalseo gu, Sydkorea, 42602
    - Novartis Investigative Site
- Gangwon-do
  - Wŏnju, Gangwon-do, Sydkorea, 26426
    - Novartis Investigative Site
- Gyeonggi-do
  - Bundang Gu, Gyeonggi-do, Sydkorea, 13620
    - Novartis Investigative Site
- Gyeongsangnam-do
  - Jinju, Gyeongsangnam-do, Sydkorea, 52727
    - Novartis Investigative Site
  - Yangsan, Gyeongsangnam-do, Sydkorea, 50612
    - Novartis Investigative Site
- Korea
  - Incheon, Korea, Sydkorea, 405 760
    - Novartis Investigative Site
  - Seoul, Korea, Sydkorea, 02447
    - Novartis Investigative Site
  - Seoul, Korea, Sydkorea, 08308
    - Novartis Investigative Site
- North Chungcheong
  - Cheongju-si, North Chungcheong, Sydkorea, 28644
    - Novartis Investigative Site
- Seoul
  - Seoul, Seoul, Sydkorea, 06351
    - Novartis Investigative Site
  - Seoul, Seoul, Sydkorea, 03080
    - Novartis Investigative Site
Taiwan
- - Kaohsiung City, Taiwan, 80756
    - Novartis Investigative Site
  - Tainan, Taiwan, 71004
    - Novartis Investigative Site
  - Tainan, Taiwan, 704302
    - Novartis Investigative Site
  - Taipei, Taiwan, 10002
    - Novartis Investigative Site
  - Taipei, Taiwan, 11217
    - Novartis Investigative Site
  - Taipei, Taiwan, 10449
    - Novartis Investigative Site
  - Taipei, Taiwan, 110
    - Novartis Investigative Site
Thailand
- - Bangkok, Thailand, 10700
    - Novartis Investigative Site
  - Bangkok, Thailand, 10400
    - Novartis Investigative Site
  - Chiang Mai, Thailand, 50200
    - Novartis Investigative Site
  - Muang, Thailand, 40002
    - Novartis Investigative Site
- Hat Yai
  - Songkhla, Hat Yai, Thailand, 90110
    - Novartis Investigative Site
- Thailand
  - Muang, Thailand, Thailand, 12120
    - Novartis Investigative Site
Tjekkiet
- - Bedihošť, Tjekkiet, 798 21
    - Novartis Investigative Site
  - Brno, Tjekkiet, 625 00
    - Novartis Investigative Site
  - Brno, Tjekkiet, 638 00
    - Novartis Investigative Site
  - Brno, Tjekkiet, 602 00
    - Novartis Investigative Site
  - Hodonín, Tjekkiet, 695 01
    - Novartis Investigative Site
  - Hradec Králové, Tjekkiet, 500 05
    - Novartis Investigative Site
  - Jihlava, Tjekkiet, 586 01
    - Novartis Investigative Site
  - Mariánské Lázně, Tjekkiet, 353 01
    - Novartis Investigative Site
  - Náchod, Tjekkiet, 547 01
    - Novartis Investigative Site
  - Ostrava, Tjekkiet, 700 30
    - Novartis Investigative Site
  - Ostrava, Tjekkiet, 728 80
    - Novartis Investigative Site
  - Ostrava, Tjekkiet, 710 00
    - Novartis Investigative Site
  - Pardubice, Tjekkiet, 532 03
    - Novartis Investigative Site
  - Polička, Tjekkiet, 57201
    - Novartis Investigative Site
  - Prague, Tjekkiet, 100 34
    - Novartis Investigative Site
  - Prague, Tjekkiet, 120 00
    - Novartis Investigative Site
  - Prague, Tjekkiet, 158 00
    - Novartis Investigative Site
  - Přerov, Tjekkiet, 751 52
    - Novartis Investigative Site
  - Příbram, Tjekkiet, 261 01
    - Novartis Investigative Site
  - Slaný, Tjekkiet, 274 01
    - Novartis Investigative Site
  - Svitavy, Tjekkiet, 568 25
    - Novartis Investigative Site
  - Třebíč, Tjekkiet, 674 01
    - Novartis Investigative Site
  - Uherské Hradiště, Tjekkiet, 686 01
    - Novartis Investigative Site
  - Zlín, Tjekkiet, 760 01
    - Novartis Investigative Site
  - Český Krumlov, Tjekkiet, 381 01
    - Novartis Investigative Site
- Czech Republic
  - Louny, Czech Republic, Tjekkiet, 440 01
    - Novartis Investigative Site
Tyrkiet (Türkiye)
- - Istanbul, Tyrkiet (Türkiye), 34147
    - Novartis Investigative Site
- Balcova
  - Izmir, Balcova, Tyrkiet (Türkiye), 35340
    - Novartis Investigative Site
- Fatih
  - Istanbul, Fatih, Tyrkiet (Türkiye), 34098
    - Novartis Investigative Site
- Kartal
  - Istanbul, Kartal, Tyrkiet (Türkiye), 34865
    - Novartis Investigative Site
- Nilufer
  - Bursa, Nilufer, Tyrkiet (Türkiye), 16140
    - Novartis Investigative Site
- Selcuklu
  - Konya, Selcuklu, Tyrkiet (Türkiye), 42130
    - Novartis Investigative Site
- Sihhiye-Altindag
  - Ankara, Sihhiye-Altindag, Tyrkiet (Türkiye), 06230
    - Novartis Investigative Site
- Yenimahalle
  - Ankara, Yenimahalle, Tyrkiet (Türkiye), 06170
    - Novartis Investigative Site
- Yuregir
  - Adana, Yuregir, Tyrkiet (Türkiye), 01230
    - Novartis Investigative Site
Ungarn
- - Baja, Ungarn, 6500
    - Novartis Investigative Site
  - Balassagyarmat, Ungarn, 2660
    - Novartis Investigative Site
  - Balatonfüred, Ungarn, 8230
    - Novartis Investigative Site
  - Budapest, Ungarn, H-1083
    - Novartis Investigative Site
  - Budapest, Ungarn, H-1145
    - Novartis Investigative Site
  - Kalocsa, Ungarn, 6300
    - Novartis Investigative Site
  - Kecskemét, Ungarn, 6001
    - Novartis Investigative Site
  - Kistarcsa, Ungarn, 2143
    - Novartis Investigative Site
  - Komárom, Ungarn, 2921
    - Novartis Investigative Site
  - Nagykanizsa, Ungarn, 8800
    - Novartis Investigative Site
  - Orosháza, Ungarn, 5900
    - Novartis Investigative Site
  - Pécs, Ungarn, 7623
    - Novartis Investigative Site
  - Szeged, Ungarn, 6725
    - Novartis Investigative Site
  - Szekszárd, Ungarn, 7100
    - Novartis Investigative Site
  - Szolnok, Ungarn, 5000
    - Novartis Investigative Site
  - Zalaegerszeg, Ungarn, 8900
    - Novartis Investigative Site
- Baranya
  - Pécs, Baranya, Ungarn, 7623
    - Novartis Investigative Site
- Csongrád megye
  - Oroshaza, Csongrád megye, Ungarn, 5900
    - Novartis Investigative Site
- Hajdu Bihar Megye
  - Debrecen, Hajdu Bihar Megye, Ungarn, 4032
    - Novartis Investigative Site
- Pest County
  - Budapest, Pest County, Ungarn, 1134
    - Novartis Investigative Site
Østrig
- - Braunau am Inn, Østrig, 5280
    - Novartis Investigative Site
  - Graz, Østrig, 8036
    - Novartis Investigative Site

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

40 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Beskrivelse

Inklusionskriterier:

Fastende LDL-C ≥ 70 mg/dL ved randomiseringsbesøg
Stabil (større end eller lig med 4 uger) og veltolereret lipidsænkende regime (inklusive f.eks. med eller uden Ezetimibe), som skal omfatte en højintensiv statinbehandling med enten atorvastatin større end eller lig med 40 mg QD eller rosuvastatin større end eller lig med 20 mg QD
Etableret CV-sygdom defineret som ENHVER af følgende tre tilstande
1. Spontan myokardieinfarkt ≥ 4 uger fra screeningsbesøg
2. Anamnese med iskæmisk slagtilfælde forekom ≥ 4 uger før screeningsbesøget
3. Symptomatisk perifer arteriel sygdom (PAD) påvist ved enten claudicatio intermittens med ankel brachial indeks (ABI) < 0,85, tidligere perifer arteriel revaskulariseringsprocedure eller amputation på grund af aterosklerotisk sygdom.

Ekskluderingskriterier:

Akut koronarsyndrom, slagtilfælde, perifer arteriel revaskulariseringsprocedure eller amputation på grund af aterosklerotisk sygdom < 4 uger før screeningsbesøg
Behandling med PCSK9-hæmmere (f. evolocumab, alirocumab) inden for 90 dage eller planlagt brug efter første studiebesøg
Planlagt eller forventet hjerte-, cerebrovaskulær eller perifer arteriekirurgi eller re-vaskularisering inden for 6 måneder efter det første studiebesøg
Hjertesvigt NYHA klasse III eller IV
Aktiv leversygdom defineret som enhver kendt nuværende infektiøs, neoplastisk eller metabolisk patologi i leveren
Tidligere eksponering for inclisiran eller enhver anden ikke-mAb PCSK9-målrettet behandling, enten som et forsøgs- eller markedsført lægemiddel inden for 2 år
Alvorlig samtidig ikke-CV-sygdom, der forventes at reducere den forventede levetid til mindre end 5 år
Anamnese med malignitet, der krævede kirurgisk strålebehandling og/eller systemisk terapi i de 3 år forud for det første studiebesøg
Gravide eller ammende (ammende) kvinder

Andre protokoldefinerede inklusions-/udelukkelseskriterier kan være gældende.

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Behandling
Tildeling: Randomiseret
Interventionel model: Parallel tildeling
Maskning: Dobbelt

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Placebo komparator: Placebo Subkutan injektion	Medicin: Placebo Subkutant injiceret på dag 1, måned 3 (dag 90) og hver 6. måned derefter indtil EOS besøg
Eksperimentel: Inclisiran natrium Subkutan injektion	Medicin: Inclisiran natrium 300 mg Subkutant injiceret på dag 1, måned 3 (dag 90) og hver 6. måned derefter indtil EOS besøg

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Tid til første forekomst af 3P-MACE (3-punkts alvorlige kardiovaskulære hændelser) Tidsramme: Fra randomisering til samlet opfølgningstid (op til 72 måneder)	3P-MACE er et bekræftet sammensat endepunkt, som inkluderer kardiovaskulær død, ikke-fatalt myokardieinfarkt og ikke-fatalt iskæmisk slagtilfælde.	Fra randomisering til samlet opfølgningstid (op til 72 måneder)

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Tid til forekomst af kardiovaskulær (CV) død Tidsramme: Fra randomisering til samlet opfølgningstid (op til 72 måneder)	CV død defineres som død som følge af kardiovaskulære hændelser	Fra randomisering til samlet opfølgningstid (op til 72 måneder)
Tid til første forekomst af 4P-MACE (4-punkts alvorlige kardiovaskulære hændelser) Tidsramme: Fra randomisering til samlet opfølgningstid (op til 72 måneder)	En sammensat 4P-MACE er defineret som CV død, ikke-dødelig MI, ikke-dødelig iskæmisk slagtilfælde og akut koronar revaskularisering.	Fra randomisering til samlet opfølgningstid (op til 72 måneder)
Tid til forekomsten af dødsfald af alle årsager Tidsramme: Fra randomisering til samlet opfølgningstid (op til 72 måneder)	Død af alle årsager er defineret som: alle dødsfald fra randomisering til op til 72 måneder	Fra randomisering til samlet opfølgningstid (op til 72 måneder)
Tid til den første forekomst af alvorlige uønskede lemmer (MALE) Tidsramme: Fra randomisering til samlet opfølgningstid (op til 72 måneder)	Større ekstreme bivirkninger, herunder akut iskæmi i underekstremiteterne, amputation af underekstremiteter på grund af iskæmi eller akut revaskularisering af underekstremiteterne for iskæmi	Fra randomisering til samlet opfølgningstid (op til 72 måneder)

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Novartis Pharmaceuticals

Efterforskere

Studieleder: Novartis Pharmaceuticals, Novartis Pharmaceuticals

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

23. november 2021

Primær færdiggørelse (Anslået)

13. oktober 2027

Studieafslutning (Anslået)

13. oktober 2027

Datoer for studieregistrering

Først indsendt

17. august 2021

Først indsendt, der opfyldte QC-kriterier

25. august 2021

Først opslået (Faktiske)

1. september 2021

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

13. maj 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

8. maj 2026

Sidst verificeret

1. maj 2026

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

CKJX839B12302

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

IPD-planbeskrivelse

Novartis er forpligtet til at dele med kvalificerede eksterne forskere, adgang til data på patientniveau og understøttende kliniske dokumenter fra kvalificerede undersøgelser. Disse anmodninger gennemgås og godkendes af et uafhængigt bedømmelsespanel på grundlag af videnskabelig fortjeneste. Alle opgivne data er anonymiseret for at respektere privatlivets fred for patienter, der har deltaget i forsøget i overensstemmelse med gældende love og regler.

Tilgængeligheden af denne forsøgsdata er i overensstemmelse med kriterierne og processen beskrevet på www.clinicalstudydatarequest.com

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Aterosklerotisk kardiovaskulær sygdom

Ottawa Hospital Research Institute

Afsluttet

Virkningen af uventet død i simulering: Fastholdelse af færdigheder, stress og følelser

Stress | Crisis Resource Management (CRM) færdigheder | Advanced Cardiovascular Life Support (ACLS) færdigheder

Canada

Kliniske forsøg med Inclisiran natrium 300 mg

Novartis Pharmaceuticals

Afsluttet

Undersøgelse af farmakokinetik, farmakodynamik, sikkerhed og tolerabilitet af Inclisiran hos kinesiske deltagere med forhøjet serum LDL-C (ORION-14)

Hyperlipidæmi

Kina
CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co....

Afsluttet

Et studie til evaluering af sikkerheden og effektiviteten af SYH2053 hos kinesiske deltagere med ikke-familial hyperkolesterolæmi og blandet hyperlipidæmi

Hyperkolesterolæmi og Blandet Hyperlipidæmi

Kina
Novartis Pharmaceuticals

Aktiv, ikke rekrutterende

Koronar computertomografiundersøgelse for at vurdere effekten af Inclisiran ud over maksimalt tolereret statinterapi på aterosklerotisk plakprogression hos deltagere med en diagnose af ikke-obstruktiv koronararteriesygdom uden tidligere kardiovaskulære hændelser (V-PLAQUE)

Koronararteriesygdom

Kina, Forenede Stater, Italien, Australien, Spanien, Frankrig, Indien, Canada, Argentina, Ungarn, Schweiz, Belgien, Det Forenede Kongerige, Japan, Irland, Sydkorea, Brasilien, Chile
Novartis Pharmaceuticals

Afsluttet

En undersøgelse af Inclisiran hos deltagere med homozygot familiær hyperkolesterolæmi (HoFH) (ORION-5)

Homozygot familiær hyperkolesterolæmi

Hong Kong, Israel, Den Russiske Føderation, Serbien, Sydafrika, Taiwan, Kalkun, Ukraine
University of California, San Diego
Novartis

Rekruttering

LDL-C-optimering ved hjælp af Inclisiran hos patienter, hvor interaktioner med lægemidler begrænser LDL-sænkning (SOLVE-LDL-C)

Primær forebyggelse | Lægemiddelinteraktioner | Kardiometabolisk syndrom | LDL-COLERSTEROL Sænkning

Forenede Stater
Mylan Pharmaceuticals Inc

Afsluttet

Fasteundersøgelse af levothyroxin-natrium-tabletter 300 μg til Synthroid®-tabletter 300 μg

Sund og rask

Forenede Stater
Mylan Pharmaceuticals Inc

Afsluttet

Fasteundersøgelse af levothyroxin-natrium-tabletter 300 μg til Levothroid®-tabletter 300 μg

Sund og rask

Forenede Stater
Novartis Pharmaceuticals

Aktiv, ikke rekrutterende

En undersøgelse af Inclisiran til forebyggelse af kardiovaskulære hændelser hos højrisikopatienter med primær forebyggelse.

Primær forebyggelse af aterosklerotisk kardiovaskulær sygdom

Forenede Stater, Kina, Sydafrika, Spanien, Kroatien, Estland, Indien, Australien, Østrig, Danmark, Frankrig, Schweiz, Det Forenede Kongerige, Canada, Thailand, Israel, Taiwan, Bulgarien, Tjekkiet, Grækenland, Holland, Polen, Rumænien, ... og mere
Duke University
Novartis Pharmaceuticals; Mount Sinai Hospital, New York; Colorado Prevention...

Rekruttering

Inklisiran versus placebo til forebyggelse af større ugunstige kardiovaskulære og lembegivenheder hos patienter, der gennemgår perkutan koronar intervention eller perifer endovaskulær intervention (V-INTERVENTION)

Perkutan koronar intervention | Perifer endovaskulær intervention

Forenede Stater
Tyra Biosciences, Inc

Rekruttering

En undersøgelse af Tyra-300 hos børn med achondroplasia: Beach301

Akondroplasi

Forenede Stater, Canada, Australien, Spanien

Undersøgelse af Inclisiran for at forhindre kardiovaskulære (CV) hændelser hos deltagere med etableret kardiovaskulær sygdom (VICTORION-2P)

Et randomiseret, dobbeltblindt, placebokontrolleret, multicenterforsøg, der vurderer virkningen af ​​Inclisiran på alvorlige uønskede kardiovaskulære hændelser hos deltagere med etableret kardiovaskulær sygdom (VICTORION-2 PREVENT)

Studieoversigt

Status

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsestype

Tilmelding (Faktiske)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Efterforskere

Datoer for undersøgelser

Studer store datoer

Studiestart (Faktiske)

Primær færdiggørelse (Anslået)

Studieafslutning (Anslået)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Faktiske)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

IPD-planbeskrivelse

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Studerer et amerikansk FDA-reguleret enhedsprodukt

Kliniske forsøg med Aterosklerotisk kardiovaskulær sygdom

Kliniske forsøg med Inclisiran natrium 300 mg

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Madagascar

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer

Et randomiseret, dobbeltblindt, placebokontrolleret, multicenterforsøg, der vurderer virkningen af Inclisiran på alvorlige uønskede kardiovaskulære hændelser hos deltagere med etableret kardiovaskulær sygdom (VICTORION-2 PREVENT)