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Studie av Inclisiran for å forhindre kardiovaskulære (CV) hendelser hos deltakere med etablert kardiovaskulær sykdom (VICTORION-2P)

24. august 2026 oppdatert av: Novartis Pharmaceuticals

En randomisert, dobbeltblind, placebokontrollert, multisenterforsøk, som vurderer effekten av Inclisiran på alvorlige uønskede kardiovaskulære hendelser hos deltakere med etablert kardiovaskulær sykdom (VICTORION-2 PREVENT)

Studie CKJX839B12302 er en sentral fase III-studie for å evaluere fordelene med inclisiran på alvorlige uønskede kardiovaskulære (MACE) hendelser hos deltakere med etablert kardiovaskulær sykdom (CVD).

Studieoversikt

Status

Aktiv, ikke rekrutterende

Forhold

Aterosklerotisk kardiovaskulær sykdom

Intervensjon / Behandling

Detaljert beskrivelse

Hensikten med denne studien er å teste hypotesen om at behandling med inclisiran natrium 300 mg s.c. administrert på dag 1, måned 3 (dag 90), og hver 6. måned deretter tatt i tillegg til godt tolerert høyintensiv statinbehandling hos deltakere med etablert ASCVD vil signifikant redusere risikoen for 3-punkts-større kardiovaskulære hendelser (3P -MACE) definert som en sammensetning av CV-død, ikke-dødelig hjerteinfarkt (MI) og ikke-dødelig iskemisk hjerneslag. Dette vil bli sammenlignet med placebo i tillegg til godt tolerert høyintensiv statinbehandling.

Studietype

Intervensjonell

Registrering (Faktiske)

17004

Fase

Fase 3

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiesteder

Argentina
- - Buenos Aires, Argentina, C1012AAR
    - Novartis Investigative Site
  - Buenos Aires, Argentina, C1428DCO
    - Novartis Investigative Site
  - Buenos Aires, Argentina, C1425AGP
    - Novartis Investigative Site
  - Caba, Argentina, C1427CCL
    - Novartis Investigative Site
  - Corrientes, Argentina, W3400CDS
    - Novartis Investigative Site
  - Córdoba, Argentina, X5002HWE
    - Novartis Investigative Site
  - Córdoba, Argentina, X5016KET
    - Novartis Investigative Site
  - Formosa, Argentina, P3600
    - Novartis Investigative Site
  - Mendoza, Argentina, 5500
    - Novartis Investigative Site
  - Santa Fe, Argentina, S3000FWO
    - Novartis Investigative Site
  - Santa Fe, Argentina, S3000EOZ
    - Novartis Investigative Site
- Buenos Aires
  - CABA, Buenos Aires, Argentina, C1221ADC
    - Novartis Investigative Site
  - CABA, Buenos Aires, Argentina, C1405BCH
    - Novartis Investigative Site
  - CABA, Buenos Aires, Argentina, C1056ABI
    - Novartis Investigative Site
  - CABA, Buenos Aires, Argentina, C1187AAN
    - Novartis Investigative Site
  - CABA, Buenos Aires, Argentina, C1426ABP
    - Novartis Investigative Site
  - CABA, Buenos Aires, Argentina, C1280AEB
    - Novartis Investigative Site
  - Caba, Buenos Aires, Argentina, C1119ACN
    - Novartis Investigative Site
  - Mar del Plata, Buenos Aires, Argentina, B7600ENA
    - Novartis Investigative Site
  - Quilmes, Buenos Aires, Argentina, B1878GEG
    - Novartis Investigative Site
  - Ramos Mejía, Buenos Aires, Argentina, B1704ETD
    - Novartis Investigative Site
  - San Martín, Buenos Aires, Argentina, B1650CSQ
    - Novartis Investigative Site
- Misiones Province
  - Posadas, Misiones Province, Argentina, N3300
    - Novartis Investigative Site
- Salta Province
  - Salta, Salta Province, Argentina, A4406BPF
    - Novartis Investigative Site
- San Miguel de Tucuman
  - San Miguel de Tucumán, San Miguel de Tucuman, Argentina, T4000ICL
    - Novartis Investigative Site
- Santa Fe Province
  - Rosario, Santa Fe Province, Argentina, S2000AII
    - Novartis Investigative Site
  - Rosario, Santa Fe Province, Argentina, S2000CVD
    - Novartis Investigative Site
  - Rosario, Santa Fe Province, Argentina, S2000DTB
    - Novartis Investigative Site
- Tucumán Province
  - San Miguel Tucuman, Tucumán Province, Argentina, T4000IFL
    - Novartis Investigative Site
Australia
- - Liverpool, Australia, 2170
    - Novartis Investigative Site
- New South Wales
  - Botany, New South Wales, Australia, 2019
    - Novartis Investigative Site
  - New Lambton Heights, New South Wales, Australia, 2305
    - Novartis Investigative Site
- Queensland
  - Auchenflower, Queensland, Australia, 4066
    - Novartis Investigative Site
  - Milton, Queensland, Australia, 4064
    - Novartis Investigative Site
  - Woolloongabba, Queensland, Australia, 4102
    - Novartis Investigative Site
- South Australia
  - Adelaide, South Australia, Australia, 5000
    - Novartis Investigative Site
  - Bedford Park, South Australia, Australia, 5041
    - Novartis Investigative Site
  - Leabrook, South Australia, Australia, 5068
    - Novartis Investigative Site
  - Woodville South, South Australia, Australia, 5011
    - Novartis Investigative Site
- Victoria
  - Clayton, Victoria, Australia, 3168
    - Novartis Investigative Site
  - Geelong, Victoria, Australia, 3220
    - Novartis Investigative Site
  - Malvern East, Victoria, Australia, 3145
    - Novartis Investigative Site
  - Richmond, Victoria, Australia, 3121
    - Novartis Investigative Site
- Western Australia
  - Joondalup, Western Australia, Australia, 6027
    - Novartis Investigative Site
  - Nedlands, Western Australia, Australia, 6009
    - Novartis Investigative Site
Belgia
- - Antwerp, Belgia, 2020
    - Novartis Investigative Site
  - Brasschaat, Belgia, 2930
    - Novartis Investigative Site
  - Bruges, Belgia, 8000
    - Novartis Investigative Site
  - Brussels, Belgia, 1020
    - Novartis Investigative Site
  - Charleroi, Belgia, 6000
    - Novartis Investigative Site
  - Edegem, Belgia, 2650
    - Novartis Investigative Site
  - Ghent, Belgia, 9000
    - Novartis Investigative Site
  - La Louvière, Belgia, 7100
    - Novartis Investigative Site
  - Ronse, Belgia, 9600
    - Novartis Investigative Site
- Limburg
  - Genk, Limburg, Belgia, 3600
    - Novartis Investigative Site
- Namur
  - Yvoir, Namur, Belgia, 5530
    - Novartis Investigative Site
- West-Vlaanderen
  - Kortrijk, West-Vlaanderen, Belgia, 8500
    - Novartis Investigative Site
  - Roeselare, West-Vlaanderen, Belgia, 8800
    - Novartis Investigative Site
Brasil
- - Campinas, Brasil, 13092-133
    - Novartis Investigative Site
  - Rio de Janeiro, Brasil, 20241-180
    - Novartis Investigative Site
  - São Paulo, Brasil, 04026-090
    - Novartis Investigative Site
- Alagoas
  - Maceió, Alagoas, Brasil, 57051-160
    - Novartis Investigative Site
- Espírito Santo
  - Vitória, Espírito Santo, Brasil, 29055-450
    - Novartis Investigative Site
- Estado de Bahia
  - Salvador, Estado de Bahia, Brasil, 40170-130
    - Novartis Investigative Site
- Federal District
  - Brasília, Federal District, Brasil, 71625-009
    - Novartis Investigative Site
  - Brasília, Federal District, Brasil, 70390-700
    - Novartis Investigative Site
- Minas Gerais
  - Belo Horizonte, Minas Gerais, Brasil, 30220-330
    - Novartis Investigative Site
  - Uberlândia, Minas Gerais, Brasil, 38400-500
    - Novartis Investigative Site
- Paraná
  - Curitiba, Paraná, Brasil, 80730-150
    - Novartis Investigative Site
- Rio Grande do Sul
  - Canoas, Rio Grande do Sul, Brasil, 92425-900
    - Novartis Investigative Site
  - Pelotas, Rio Grande do Sul, Brasil, 96015-290
    - Novartis Investigative Site
  - Porto Alegre, Rio Grande do Sul, Brasil, 90880-480
    - Novartis Investigative Site
  - Porto Alegre, Rio Grande do Sul, Brasil, 90560-032
    - Novartis Investigative Site
  - Porto Alegre, Rio Grande do Sul, Brasil, 90160-093
    - Novartis Investigative Site
- Santa Catarina
  - Blumenau, Santa Catarina, Brasil, 89020-430
    - Novartis Investigative Site
- Sergipe
  - Aracaju, Sergipe, Brasil, 49055-530
    - Novartis Investigative Site
- São Paulo
  - Campinas, São Paulo, Brasil, 13060-080
    - Novartis Investigative Site
  - Ribeirão Preto, São Paulo, Brasil, 14048-900
    - Novartis Investigative Site
  - Santo André, São Paulo, Brasil, 09030-010
    - Novartis Investigative Site
  - Santo André, São Paulo, Brasil, 09060-870
    - Novartis Investigative Site
  - Santo André, São Paulo, Brasil, 09090-790
    - Novartis Investigative Site
  - Sao Jose Rio Preto, São Paulo, Brasil, 15015-750
    - Novartis Investigative Site
  - Sao Jose Rio Preto, São Paulo, Brasil, 15090-000
    - Novartis Investigative Site
  - São Paulo, São Paulo, Brasil, 01323-903
    - Novartis Investigative Site
  - São Paulo, São Paulo, Brasil, 04005-003
    - Novartis Investigative Site
  - São Paulo, São Paulo, Brasil, 05403-000
    - Novartis Investigative Site
  - São Paulo, São Paulo, Brasil, 04266-010
    - Novartis Investigative Site
  - São Paulo, São Paulo, Brasil, 09715-090
    - Novartis Investigative Site
Bulgaria
- - Burgas, Bulgaria, 8000
    - Novartis Investigative Site
  - Haskovo, Bulgaria, 6304
    - Novartis Investigative Site
  - Kyustendil, Bulgaria, 2500
    - Novartis Investigative Site
  - Montana, Bulgaria, 3400
    - Novartis Investigative Site
  - Pernik, Bulgaria, 2300
    - Novartis Investigative Site
  - Pleven, Bulgaria, 5800
    - Novartis Investigative Site
  - Plovdiv, Bulgaria, 4000
    - Novartis Investigative Site
  - Rousse, Bulgaria, 7000
    - Novartis Investigative Site
  - Rousse, Bulgaria, 7012
    - Novartis Investigative Site
  - Sliven, Bulgaria, 8800
    - Novartis Investigative Site
  - Sofia, Bulgaria, 1527
    - Novartis Investigative Site
  - Sofia, Bulgaria, 1113
    - Novartis Investigative Site
  - Sofia, Bulgaria, 1431
    - Novartis Investigative Site
  - Sofia, Bulgaria, 1407
    - Novartis Investigative Site
  - Sofia, Bulgaria, 1202
    - Novartis Investigative Site
  - Sofia, Bulgaria, 1750
    - Novartis Investigative Site
  - Sofia, Bulgaria, 1510
    - Novartis Investigative Site
  - Sofia, Bulgaria, 1582
    - Novartis Investigative Site
  - Stamboliyski, Bulgaria, 4210
    - Novartis Investigative Site
  - Stara Zagora, Bulgaria, 6000
    - Novartis Investigative Site
  - Stara Zagora, Bulgaria, 6003
    - Novartis Investigative Site
  - Veliko Tarnovo, Bulgaria, 5000
    - Novartis Investigative Site
- Blagoevgrad
  - Sandanski, Blagoevgrad, Bulgaria, 2850
    - Novartis Investigative Site
- Sofia-Grad
  - Sofia, Sofia-Grad, Bulgaria, 1040
    - Novartis Investigative Site
Canada
- Alberta
  - Calgary, Alberta, Canada, T2N 4N1
    - Novartis Investigative Site
  - Edmonton, Alberta, Canada, T5H 4B9
    - Novartis Investigative Site
  - Edmonton, Alberta, Canada, T6K 4C1
    - Novartis Investigative Site
- British Columbia
  - Longueuil, British Columbia, Canada, J4H 4B9
    - Novartis Investigative Site
  - North Vancouver, British Columbia, Canada, V7M 2H4
    - Novartis Investigative Site
  - Vancouver, British Columbia, Canada, V6Z 1Y6
    - Novartis Investigative Site
  - Vancouver, British Columbia, Canada, V5Z 1M9
    - Novartis Investigative Site
  - Victoria, British Columbia, Canada, V8R4R2
    - Novartis Investigative Site
  - Victoria, British Columbia, Canada, V8T 5G4
    - Novartis Investigative Site
  - Victoria, British Columbia, Canada, V8V 4A1
    - Novartis Investigative Site
- Manitoba
  - Winnipeg, Manitoba, Canada, R3C 0N2
    - Novartis Investigative Site
  - Winnipeg, Manitoba, Canada, R3L 1Z5
    - Novartis Investigative Site
- New Brunswick
  - Moncton, New Brunswick, Canada, E1G 1A7
    - Novartis Investigative Site
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 2Y9
    - Novartis Investigative Site
  - Sydney, Nova Scotia, Canada, B1P 1P3
    - Novartis Investigative Site
- Ontario
  - Cambridge, Ontario, Canada, N1R 7R1
    - Novartis Investigative Site
  - Guelph, Ontario, Canada, N1H 1B1
    - Novartis Investigative Site
  - Newmarket, Ontario, Canada, L3Y 2P6
    - Novartis Investigative Site
  - Oakville, Ontario, Canada, L6K 3W7
    - Novartis Investigative Site
  - Peterborough, Ontario, Canada, K9J 0B2
    - Novartis Investigative Site
  - Sarnia, Ontario, Canada, N7T 4X3
    - Novartis Investigative Site
  - Scarborough Village, Ontario, Canada, M1B 4Z8
    - Novartis Investigative Site
  - Scarborough Village, Ontario, Canada, M1B 5N1
    - Novartis Investigative Site
  - Stoufville, Ontario, Canada, L4A 1H2
    - Novartis Investigative Site
- Quebec
  - Montreal, Quebec, Canada, H2X 1R9
    - Novartis Investigative Site
  - Montreal, Quebec, Canada, H3M 1L3
    - Novartis Investigative Site
  - Montreal, Quebec, Canada, H4N 2W2
    - Novartis Investigative Site
  - Québec, Quebec, Canada, G1W 4R4
    - Novartis Investigative Site
  - Québec, Quebec, Canada, G2J 0C4
    - Novartis Investigative Site
  - Québec, Quebec, Canada, G1V 4G5
    - Novartis Investigative Site
  - Saint-Jérôme, Quebec, Canada, J7Z 5T3
    - Novartis Investigative Site
  - Sainte-Foy, Quebec, Canada, G1V 4G2
    - Novartis Investigative Site
  - Terrebonne, Quebec, Canada, J6V 2H2
    - Novartis Investigative Site
  - Trois-Rivières, Quebec, Canada, G8Z 3R9
    - Novartis Investigative Site
Chile
- - Santiago, Chile, 8380456
    - Novartis Investigative Site
- Araucania
  - Temuco, Araucania, Chile, 4781156
    - Novartis Investigative Site
  - Victoria, Araucania, Chile, 4720097
    - Novartis Investigative Site
- Coquimbo Region
  - La Serena, Coquimbo Region, Chile, 1720430
    - Novartis Investigative Site
- Los Lagos Region
  - Osorno, Los Lagos Region, Chile, 5290000
    - Novartis Investigative Site
- Santiago Metropolitan
  - Santiago, Santiago Metropolitan, Chile, 8331143
    - Novartis Investigative Site
  - Santiago, Santiago Metropolitan, Chile, 7500710
    - Novartis Investigative Site
  - Santiago, Santiago Metropolitan, Chile, 8380465
    - Novartis Investigative Site
- Valparaiso
  - Viña del Mar, Valparaiso, Chile, 2520997
    - Novartis Investigative Site
Colombia
- - Barranquilla, Colombia, 080020
    - Novartis Investigative Site
  - Bogotá, Colombia, 110221
    - Novartis Investigative Site
  - Cali, Colombia, 760024
    - Novartis Investigative Site
  - Floridablanca, Colombia, 681017
    - Novartis Investigative Site
- Antioquia
  - Medellín, Antioquia, Colombia, 050021
    - Novartis Investigative Site
  - Medellín, Antioquia, Colombia, 050036
    - Novartis Investigative Site
- Atlántico
  - Barranquilla, Atlántico, Colombia, 080002
    - Novartis Investigative Site
  - Barranquilla, Atlántico, Colombia, 080020
    - Novartis Investigative Site
- Caldas Department
  - Manizales, Caldas Department, Colombia, 170001
    - Novartis Investigative Site
- Departamento de Bolívar
  - Cartagena, Departamento de Bolívar, Colombia, 130001
    - Novartis Investigative Site
- Risaralda Department
  - Pereira, Risaralda Department, Colombia, 660003
    - Novartis Investigative Site
- Valle del Cauca Department
  - Cali, Valle del Cauca Department, Colombia, 760001
    - Novartis Investigative Site
  - Cali, Valle del Cauca Department, Colombia, 760032
    - Novartis Investigative Site
Danmark
- - Aarhus N, Danmark, 8200
    - Novartis Investigative Site
  - Esbjerg, Danmark, 6700
    - Novartis Investigative Site
  - Glostrup Municipality, Danmark, 2600
    - Novartis Investigative Site
  - Herlev, Danmark, 2730
    - Novartis Investigative Site
  - Hjørring, Danmark, 9800
    - Novartis Investigative Site
  - Roskilde, Danmark, 4000
    - Novartis Investigative Site
  - Svendborg, Danmark, 5700
    - Novartis Investigative Site
  - Viborg, Danmark, 8800
    - Novartis Investigative Site
- Central Jutland
  - Herning, Central Jutland, Danmark, 7400
    - Novartis Investigative Site
Estland
- - Pärnu, Estland, 80018
    - Novartis Investigative Site
  - Tallinn, Estland, 13419
    - Novartis Investigative Site
  - Tallinn, Estland, 10138
    - Novartis Investigative Site
  - Tallinn, Estland, 13619
    - Novartis Investigative Site
  - Tallinn, Estland, 10117
    - Novartis Investigative Site
  - Tartu, Estland, 50406
    - Novartis Investigative Site
  - Tartu, Estland, 50708
    - Novartis Investigative Site
Filippinene
- - Iloilo City, Filippinene, 5000
    - Novartis Investigative Site
  - Quezon, Filippinene, 1102
    - Novartis Investigative Site
  - San Juan City, Filippinene, 1502
    - Novartis Investigative Site
- Pampanga
  - San Fernando City, Pampanga, Filippinene, 2000
    - Novartis Investigative Site
Finland
- - Helsinki, Finland, 00370
    - Novartis Investigative Site
  - Jyväskylä, Finland, 40620
    - Novartis Investigative Site
  - Turku, Finland, 20520
    - Novartis Investigative Site
  - Turku, Finland, 20100
    - Novartis Investigative Site
- Northern Savonia
  - Kuopio, Northern Savonia, Finland, 70600
    - Novartis Investigative Site
Forente stater
- Alabama
  - Birmingham, Alabama, Forente stater, 35211
    - UAB St Vincents
  - Fairhope, Alabama, Forente stater, 36532
    - Eastern Shore Research Institute
  - Foley, Alabama, Forente stater, 36535
    - G and L Research LLC
- Alaska
  - Anchorage, Alaska, Forente stater, 99508
    - Alaska Heart and Vascular
- Arizona
  - Gilbert, Arizona, Forente stater, 85297
    - Mercy Gilbert Medical Center
  - Mesa, Arizona, Forente stater, 85206
    - Cardiovascular Associates of Mesa
  - Phoenix, Arizona, Forente stater, 85018
    - Elite Clinical Studies
  - Scottsdale, Arizona, Forente stater, 85258
    - HonorHealth Heart Group Deer Valley
  - Sun City West, Arizona, Forente stater, 85375
    - Clinical Research Inst of Arizona
  - Tucson, Arizona, Forente stater, 85741
    - Pima Heart And Vascular Clin Rch
- Arkansas
  - Little Rock, Arkansas, Forente stater, 72205
    - Arkansas Clinical Research
  - Little Rock, Arkansas, Forente stater, 72205
    - ARcare Center for Clinical Research
- California
  - Bakersfield, California, Forente stater, 93308
    - Central Cardiology Medical Center
  - Canoga Park, California, Forente stater, 91303
    - Alliance Clinical
  - Chino, California, Forente stater, 91710
    - Inland Psychiatric Medical Group
  - Concord, California, Forente stater, 94520
    - John Muir Physician Network Clinical Research Center
  - Fullerton, California, Forente stater, 92835
    - Triallogix
  - Huntington Beach, California, Forente stater, 92648
    - Diabetes Lipid Management Center
  - Irvine, California, Forente stater, 92660
    - University of Calif Irvine Med Cntr
  - La Jolla, California, Forente stater, 92037
    - UC San Diego Health
  - Los Angeles, California, Forente stater, 90017
    - American Institute of Research
  - Los Angeles, California, Forente stater, 90095
    - University of California LA
  - Los Angeles, California, Forente stater, 90033
    - Keck Medical Center USC
  - Palo Alto, California, Forente stater, 94304-1207
    - VA Palo Alto Health Care System
  - San Diego, California, Forente stater, 92161
    - San Diego Veterans Medical Center
  - San Ramon, California, Forente stater, 94582
    - West Coast Research LLC
  - Santa Ana, California, Forente stater, 92705
    - Syrentis Clinical Research
  - Santa Ana, California, Forente stater, 92704
    - Helping Hands Medical Associates INC
  - Spring Valley, California, Forente stater, 91978
    - Encompass Clinical Research
  - Stanford, California, Forente stater, 94304
    - Stanford University Medical Center
  - Stockton, California, Forente stater, 95204
    - Manshadi Heart Institute
  - Torrance, California, Forente stater, 90502
    - Harbor UCLA Medical Center
  - Vista, California, Forente stater, 92081
    - Blue Coast Research Center LLC
  - West Hills, California, Forente stater, 91307
    - Interv Cardiology Med Grp
- Colorado
  - Aurora, Colorado, Forente stater, 80012
    - Aurora Denver Cardiology Associates
  - Aurora, Colorado, Forente stater, 80045
    - Rocky Mountain Regional VA Med Ctr
- Connecticut
  - Bridgeport, Connecticut, Forente stater, 06610
    - Bridgeport Hospital
  - Greenwich, Connecticut, Forente stater, 06830
    - d-b-a Greenwich Cardio Assoc
  - Waterbury, Connecticut, Forente stater, 06708
    - Chase Medical Research LLC
- District of Columbia
  - Washington D.C., District of Columbia, Forente stater, 20020
    - Emerson Clinical Research Institute
- Florida
  - Boca Raton, Florida, Forente stater, 33434
    - Excel Medical Clinical Trials LLC
  - Bradenton, Florida, Forente stater, 34209
    - Cardiovascular and Vein Center of Florida
  - Bradenton, Florida, Forente stater, 34209
    - Nova Clinical Research LLC
  - Clearwater, Florida, Forente stater, 33756
    - Bay Care Medical Group
  - Daytona Beach, Florida, Forente stater, 32117
    - Cardiology Research Associates
  - DeLand, Florida, Forente stater, 32720
    - Hillcrest Medical Research
  - Hialeah, Florida, Forente stater, 33013
    - National Research Institute
  - Hialeah, Florida, Forente stater, 33013
    - Sister Life Research Inc
  - Hollywood, Florida, Forente stater, 33021
    - Zenith Clinical Research
  - Jacksonville, Florida, Forente stater, 32205
    - Westside Center for Clinical Research
  - Jacksonville, Florida, Forente stater, 32209
    - UF Health Science Center
  - Jacksonville Beach, Florida, Forente stater, 32250
    - Baptist Heart Specialists
  - Lake Worth, Florida, Forente stater, 33461
    - United Vein and Vascular Centers
  - Miami, Florida, Forente stater, 33133
    - Infinite Clinical Research
  - Miami, Florida, Forente stater, 33186
    - A&A Research Group Inc
  - Miami Lakes, Florida, Forente stater, 33014
    - Inpatient Research Clinical LLC
  - Miami Lakes, Florida, Forente stater, 33014
    - RM Medical Research Inc
  - Miami Lakes, Florida, Forente stater, 33016
    - Indago Research and Health Ctr Inc
  - Miramar, Florida, Forente stater, 33027
    - FXM Clin Res Miramar LLC
  - Naples, Florida, Forente stater, 34102
    - Advanced Research for Health Improvement LLC
  - Ocala, Florida, Forente stater, 34471
    - Ocala Cardiovascular Research
  - Oviedo, Florida, Forente stater, 32765
    - Oviedo Medical Research
  - Palm Springs, Florida, Forente stater, 33406
    - CTMD Research
  - Pembroke Pines, Florida, Forente stater, 33024
    - Broward Research Center
  - Pensacola, Florida, Forente stater, 32503
    - SEC Clinical Research
  - Port Charlotte, Florida, Forente stater, 33952
    - Peace River Cardiovascular Center
  - St. Petersburg, Florida, Forente stater, 33713
    - Advanced Medical Research Center
  - Tampa, Florida, Forente stater, 33614
    - Genesis Clinical Research
  - Tampa, Florida, Forente stater, 33603
    - New Tampa Health
  - Tampa, Florida, Forente stater, 33880
    - Ravessa Clinical Research
  - Tampa, Florida, Forente stater, 33612
    - James A Haley Veterans Hospital
  - Tampa, Florida, Forente stater, 33705
    - BayCare Health System
  - Tampa, Florida, Forente stater, 33607
    - Baycare Medical Group Inc
  - Wellington, Florida, Forente stater, 33449
    - Cardiology Partners Clinical Research Institute
- Georgia
  - Fayetteville, Georgia, Forente stater, 30214
    - Javara Research
  - Gainesville, Georgia, Forente stater, 30501
    - Northeast Georgia Medical Center
  - Peachtree Corners, Georgia, Forente stater, 30092
    - Alta Pharmaceutical Research Center
  - Tucker, Georgia, Forente stater, 30084
    - Atlanta Heart Specialists LLC
- Idaho
  - Meridian, Idaho, Forente stater, 83646
    - Solaris Clinical Research
  - Nampa, Idaho, Forente stater, 83686
    - Saltzer Health
- Illinois
  - Addison, Illinois, Forente stater, 60101
    - Biofortis Research
  - Arlington Heights, Illinois, Forente stater, 60005
    - Endeavor Health Clinical Op- NCH
  - Chicago, Illinois, Forente stater, 60607
    - Cedar Crosse Research Ct
  - Chicago, Illinois, Forente stater, 60607
    - Chicago Clinical Research Inst
  - Jerseyville, Illinois, Forente stater, 62052
    - Gateway Cardiology PC
  - Peoria, Illinois, Forente stater, 61603
    - Methodist Med Center Of Illinois
  - Springfield, Illinois, Forente stater, 62702
    - SIU School of Medicine
  - Springfield, Illinois, Forente stater, 62769
    - Prairie Heart Institute
- Indiana
  - Elkhart, Indiana, Forente stater, 46514
    - Elkhart Cardiology Group
  - Indianapolis, Indiana, Forente stater, 46237
    - Franciscan Health Services Research Center
  - Lebanon, Indiana, Forente stater, 46052
    - Witham Heart Partners
  - Merrillville, Indiana, Forente stater, 46410
    - The Heart Center of Lake County
  - Munster, Indiana, Forente stater, 46321
    - Cardiovascular Research of Northwest Indiana, LLC
- Iowa
  - Waterloo, Iowa, Forente stater, 50702
    - Covenant Medical Center
- Kansas
  - Kansas City, Kansas, Forente stater, 66160
    - University of Kansas Hospital
  - Overland Park, Kansas, Forente stater, 66211
    - Midwest Heart and Vascular Spec
  - Topeka, Kansas, Forente stater, 66606
    - Cotton O Neil Clinical Res Center
  - Wichita, Kansas, Forente stater, 67214
    - Ascension Via Christi Research
- Kentucky
  - Lexington, Kentucky, Forente stater, 40536
    - University of Kentucky College of Health Sciences
  - Louisville, Kentucky, Forente stater, 40202
    - U of Louisville Rudd Heart and Lung
- Louisiana
  - Alexandria, Louisiana, Forente stater, 71301
    - Christus Health Central Louisiana
  - Baton Rouge, Louisiana, Forente stater, 70808
    - Louisiana Cardiology Associates
  - Bossier City, Louisiana, Forente stater, 71111
    - Grace Research Llc
  - Covington, Louisiana, Forente stater, 70433
    - Cardiovascular Associates Research
  - Covington, Louisiana, Forente stater, 70433
    - Louisiana Heart Center Research
  - Crowley, Louisiana, Forente stater, 70526
    - Avant Research Associates LLC
  - Eunice, Louisiana, Forente stater, 70535
    - Horizon Research Group of Opelousas LLC
  - Gray, Louisiana, Forente stater, 70359
    - Cardiovascular Institute South ASC
  - Hammond, Louisiana, Forente stater, 70403
    - Heart Clinic of Hammond
  - Lafayette, Louisiana, Forente stater, 70503
    - CV Ins of the South
  - Mandeville, Louisiana, Forente stater, 70471
    - Clinical Trials Management LLC
  - Mandeville, Louisiana, Forente stater, 70448
    - North Shore Heart and Vascular
  - Metairie, Louisiana, Forente stater, 70006
    - Omega Clinical Research
  - Monroe, Louisiana, Forente stater, 71201
    - Clinical Trials of America LA LLC
  - Natchitoches, Louisiana, Forente stater, 71457
    - Barnum Medical Research Inc
  - New Orleans, Louisiana, Forente stater, 70115
    - Crescent City Physicians Inc
  - Opelousas, Louisiana, Forente stater, 70570
    - CV Ins of the South
  - Shreveport, Louisiana, Forente stater, 71105
    - Grace Research Llc
  - Slidell, Louisiana, Forente stater, 70458
    - Louisiana Heart Center Research
  - Zachary, Louisiana, Forente stater, 70791
    - Southern Clinical Research
- Maryland
  - Baltimore, Maryland, Forente stater, 21209
    - Sinai Ct for Throm Res and Drug Dev
  - Beltsville, Maryland, Forente stater, 20705
    - Metropolitan Cardiovascular Consultants Llc
  - Columbia, Maryland, Forente stater, 21044
    - Johns Hopkins University
  - Ft. Washington, Maryland, Forente stater, 20744
    - Anderson Medical Research
  - Glenn Dale, Maryland, Forente stater, 20769
    - Javara Inc
  - Lanham, Maryland, Forente stater, 20706
    - Capitol Cardiology Associates
  - Oxon Hill, Maryland, Forente stater, 20745
    - MD Medical Research
  - Rockville, Maryland, Forente stater, 20850
    - Adventist HealthCare Shady Grove Medical Center
  - Salisbury, Maryland, Forente stater, 21804
    - Tidal Health Peninsula Regional Inc
- Massachusetts
  - Boston, Massachusetts, Forente stater, 02215
    - Beth Israel Deaconess Medical Center
  - Boston, Massachusetts, Forente stater, 02111
    - Tufts Medical Center
  - Boston, Massachusetts, Forente stater, 02115
    - Dana Farber Cancer Institute
  - Boston, Massachusetts, Forente stater, 02132
    - VA Boston Healthcare System
  - Methuen, Massachusetts, Forente stater, 01844
    - ActivMed Practices and Research
- Michigan
  - Detroit, Michigan, Forente stater, 48202
    - Henry Ford Hospital
  - Flint, Michigan, Forente stater, 48504
    - AA Medical Research Center
  - Grand Rapids, Michigan, Forente stater, 49546
    - Healthy Heart Cardiology
  - Lansing, Michigan, Forente stater, 48910
    - McLaren Greater Lansing
  - Midland, Michigan, Forente stater, 48670
    - MyMichigan Medical Center Midland
  - Saginaw, Michigan, Forente stater, 48601
    - Central Michigan University
  - Southfield, Michigan, Forente stater, 48075
    - Providence Hospital Patient Care Research
  - Traverse City, Michigan, Forente stater, 49684
    - Traverse Heart and Vascular
  - Ypsilanti, Michigan, Forente stater, 48197
    - Trinity Health Michigan Heart
- Minnesota
  - Duluth, Minnesota, Forente stater, 55805
    - St Marys Medical Center
  - Minneapolis, Minnesota, Forente stater, 55455
    - University of Minnesota
  - Robbinsdale, Minnesota, Forente stater, 55422
    - North Memorial Heart and Vascular Institute
  - Saint Cloud, Minnesota, Forente stater, 56303
    - Centracare Heart and Vascular Center
  - Saint Paul, Minnesota, Forente stater, 55101
    - Regions Hospital
- Mississippi
  - Belzoni, Mississippi, Forente stater, 39038
    - Belzoni Clinical Research
  - Jackson, Mississippi, Forente stater, 39216
    - Jackson Heart Clinic
  - Jackson, Mississippi, Forente stater, 39216
    - VAMC Research-G V Sonny Montgomery Clinic
  - Tupelo, Mississippi, Forente stater, 38801
    - Cardiology Associates of North MS
  - Yazoo City, Mississippi, Forente stater, 39194
    - Yazoo Clinical Research
  - Yazoo City, Mississippi, Forente stater, 39194
    - Yazoo Clinical Research .
- Missouri
  - Kansas City, Missouri, Forente stater, 64128
    - Kansas City VA Medical Center
  - North Kansas City, Missouri, Forente stater, 64116
    - North Kansas City Hospital
  - Springfield, Missouri, Forente stater, 65804
    - Mercy Hospital
  - St Louis, Missouri, Forente stater, 63128
    - Mercy South
  - St Louis, Missouri, Forente stater, 63125-4181
    - St Louis V A Medical Center
  - St Louis, Missouri, Forente stater, 63128
    - Gateway Cardiovascular Rsch Ctr Inc
  - St Louis, Missouri, Forente stater, 63136
    - St Louis Heart and Vascular
- Nebraska
  - Lincoln, Nebraska, Forente stater, 68516
    - Physician Research Collaboration
  - Omaha, Nebraska, Forente stater, 68130
    - CCT Research
  - Omaha, Nebraska, Forente stater, 68105
    - VA Med NWI Endocrine Studies R151
- Nevada
  - Henderson, Nevada, Forente stater, 89074
    - Las Vegas Endocrinology
  - Las Vegas, Nevada, Forente stater, 89119
    - AB Clinical Trials
  - Las Vegas, Nevada, Forente stater, 89121
    - Clinical Research of South Nevada
- New Hampshire
  - Manchester, New Hampshire, Forente stater, 03062
    - Catholic Medical Center
- New Jersey
  - Haddon Heights, New Jersey, Forente stater, 08035
    - Cooper University Health Care
  - Linden, New Jersey, Forente stater, 07036
    - New Jersey Heart
  - Manalapan, New Jersey, Forente stater, 07726
    - Garden State Heart Care
  - New Brunswick, New Jersey, Forente stater, 08901
    - Robert Wood Johnson Medical School
  - Newark, New Jersey, Forente stater, 07112
    - Newark Beth Israel Medical Center
  - Ridgewood, New Jersey, Forente stater, 07450
    - The Valley Hospital
  - Somerset, New Jersey, Forente stater, 08873
    - Cardio Metabolic Institute
- New Mexico
  - Albuquerque, New Mexico, Forente stater, 87102
    - New Mexico Heart Institute
- New York
  - Albany, New York, Forente stater, 12206
    - Albany Medical College
  - Binghamton, New York, Forente stater, 13901
    - Meridian Clinical Research
  - Cooperstown, New York, Forente stater, 13326
    - Bassett Medical Center
  - Endwell, New York, Forente stater, 13760
    - Meridian Clinical Research LLC
  - Mineola, New York, Forente stater, 11501
    - NYU Langone Hlth Card Assoc
  - New York, New York, Forente stater, 10021
    - Weill Cornell Medical Center
  - New York, New York, Forente stater, 10029
    - Icahn School of Med at Mt Sinai
  - Northport, New York, Forente stater, 11768
    - Northport VA Medical Center
  - Rochester, New York, Forente stater, 14609
    - Rochester Clinical Research
  - Stony Brook, New York, Forente stater, 11794-3362
    - State Uni of NY at Stony Brook
  - Valhalla, New York, Forente stater, 10595
    - Westchester Medical Center
- North Carolina
  - Charlotte, North Carolina, Forente stater, 28277
    - Tryon Medical Partners PLLC
  - Charlotte, North Carolina, Forente stater, 28204
    - Novant Health Heart Vas Inst
  - Morehead City, North Carolina, Forente stater, 28557
    - Lucas Research
  - Raleigh, North Carolina, Forente stater, 27607
    - NC Heart and Vascular Research LLC
  - Salisbury, North Carolina, Forente stater, 28144
    - Accellacare of Salisbury
  - Winston-Salem, North Carolina, Forente stater, 27157
    - Wake Forest University Baptist Medical Center
- North Dakota
  - Grand Forks, North Dakota, Forente stater, 58201
    - Altru Health Research Dept.
- Ohio
  - Akron, Ohio, Forente stater, 44309
    - Akron Hospital Summa Health System
  - Cincinnati, Ohio, Forente stater, 45267
    - University of Cincinnati
  - Cincinnati, Ohio, Forente stater, 45246
    - Velocity Clin Research Springdale
  - Cleveland, Ohio, Forente stater, 44106-5028
    - Univ Hosp Cleveland Medical Center
  - Dayton, Ohio, Forente stater, 45414
    - Premier Cardiovascular Institute
  - Kettering, Ohio, Forente stater, 45429
    - Kettering Medical Center
  - Marion, Ohio, Forente stater, 43302
    - Rama Research LLC
  - Springfield, Ohio, Forente stater, 45504
    - Heart House Research Foundation
  - Toledo, Ohio, Forente stater, 43608
    - Mercy Health St Vincent Med Ctr
- Oklahoma
  - Tulsa, Oklahoma, Forente stater, 74133
    - Oklahoma Heart Institute
- Oregon
  - Bend, Oregon, Forente stater, 97701
    - Bend Memorial Clinic
  - Corvallis, Oregon, Forente stater, 97330
    - Samaritan Cardiology
- Pennsylvania
  - Abington, Pennsylvania, Forente stater, 19001
    - Abington Memorial Hospital
  - Butler, Pennsylvania, Forente stater, 16001
    - Independence Health System Cardiovascular Consultants
  - Pittsburgh, Pennsylvania, Forente stater, 15213
    - UPMC
  - Pittsburgh, Pennsylvania, Forente stater, 15236
    - Preferred Primary Care Physicians
  - Pittsburgh, Pennsylvania, Forente stater, 15243
    - Preferred Primary Care Physicians
  - Smithfield, Pennsylvania, Forente stater, 15478
    - Frontier Clinical Research LLC
- Rhode Island
  - Warwick, Rhode Island, Forente stater, 02886
    - Kent County Memorial Hospital
- South Carolina
  - Charleston, South Carolina, Forente stater, 29425
    - Medical Univ Of South Carolina
  - Columbia, South Carolina, Forente stater, 29203
    - Columbia Heart Clinic
  - Columbia, South Carolina, Forente stater, 29209
    - Columbia VA Health Care System
  - Greenville, South Carolina, Forente stater, 29615
    - Prisma Health Upstate
  - Greenville, South Carolina, Forente stater, 29607
    - Bon Secours Medical Group
  - Ladson, South Carolina, Forente stater, 29465
    - Trident Cardiology
  - Myrtle Beach, South Carolina, Forente stater, 29588
    - Family Medicine of Sayebrook
- South Dakota
  - Sioux Falls, South Dakota, Forente stater, 57104
    - Sanford USD Medical Center
  - Sioux Falls, South Dakota, Forente stater, 57105
    - North Central Heart
- Tennessee
  - Greenville, Tennessee, Forente stater, 37745
    - Wellmont CVA Heart Institute
  - Jackson, Tennessee, Forente stater, 38301
    - The Jackson Clinic PA
  - Jackson, Tennessee, Forente stater, 38301
    - Apex Cardiology Research Associates of Jackson
  - Knoxville, Tennessee, Forente stater, 37934
    - Turkey Creek Medical Center
  - Knoxville, Tennessee, Forente stater, 37938
    - Accellacare
  - Memphis, Tennessee, Forente stater, 38119
    - Memphis Cardiology and Vein Ct
  - Powell, Tennessee, Forente stater, 37849
    - Cardiovascular Res of Knoxville LLC
  - Tullahoma, Tennessee, Forente stater, 37388
    - Tennessee Center For Clinical Trials
- Texas
  - Amarillo, Texas, Forente stater, 79106
    - PharmaTex Research LLC
  - Bedford, Texas, Forente stater, 76021
    - North Hills Medical Research Inc
  - Conroe, Texas, Forente stater, 77384
    - Javara Research
  - Dallas, Texas, Forente stater, 75216
    - VA North Texas Health Care System
  - Dallas, Texas, Forente stater, 75231
    - North Texas Endocrine Center
  - Dallas, Texas, Forente stater, 75226
    - Soltero Cardiovascular Research Center
  - Dallas, Texas, Forente stater, 75231
    - Texas Health Physicians Group
  - Dallas, Texas, Forente stater, 75235
    - SW Family Medicine Associates
  - Dallas, Texas, Forente stater, 75231
    - Research Institute of Dallas PA
  - Dallas, Texas, Forente stater, 78503
    - Alina Clinical Trials
  - El Paso, Texas, Forente stater, 79905
    - David Turbay MD PLLC
  - Fort Worth, Texas, Forente stater, 76107
    - Texas Health Physicians Group
  - Fort Worth, Texas, Forente stater, 76104
    - Texas Health Physicians Group
  - Houston, Texas, Forente stater, 77030
    - Houston Methodist Hospital
  - Houston, Texas, Forente stater, 77034
    - Orion Medical
  - Houston, Texas, Forente stater, 77030
    - UT Physicians Memorial Hermann
  - Houston, Texas, Forente stater, 77084
    - Village Medical Village MD S Tx
  - Lampasas, Texas, Forente stater, 76550
    - FMC Science
  - Livingston, Texas, Forente stater, 77351
    - East Texas Research Associates Inc.
  - McKinney, Texas, Forente stater, 75071
    - CardioVoyage LLC
  - Pflugerville, Texas, Forente stater, 78660-3015
    - Discovery Clinical Trials
  - Plano, Texas, Forente stater, 75075
    - Heartplace-Plano
  - San Antonio, Texas, Forente stater, 78240
    - Endeavor Clinical Trials
  - San Antonio, Texas, Forente stater, 78229
    - South Texas Cardiovascular Consultants PLLC
  - San Antonio, Texas, Forente stater, 78229-3900
    - University of Texas Health Science Ctr
  - Sherman, Texas, Forente stater, 75090
    - Sherman Clinical Research
  - Stephenville, Texas, Forente stater, 76401
    - Javara Research
  - Sugar Land, Texas, Forente stater, 77478
    - Privia Medical Group Gulf Coast
- Utah
  - Bountiful, Utah, Forente stater, 84010
    - Progressive Clinical Research
- Virginia
  - Burke, Virginia, Forente stater, 22015
    - Burke Internal Medicine and Research
  - Forest, Virginia, Forente stater, 24551
    - Javara Research
  - Hopewell, Virginia, Forente stater, 23860
    - Heart Care Associates P C
  - Norfolk, Virginia, Forente stater, 23504
    - York Clinical Research
  - Richmond, Virginia, Forente stater, 23219
    - Dominion Medical Associates
  - Roanoke, Virginia, Forente stater, 24014
    - Roanoke Heart Institute
  - Winchester, Virginia, Forente stater, 22601
    - Winchester Medical Center
- Washington
  - Seattle, Washington, Forente stater, 98195
    - University of Washington
  - Seattle, Washington, Forente stater, 98101
    - Virginia Mason Medical Centre
  - Seattle, Washington, Forente stater, 98122
    - Swedish Medical Center-Cardiovascular Research
  - Tacoma, Washington, Forente stater, 98405
    - Universal Research Group LLC
  - Wenatchee, Washington, Forente stater, 98801
    - Confluence Health Hospital
Frankrike
- - Amiens, Frankrike, 80054
    - Novartis Investigative Site
  - Brest, Frankrike, 29200
    - Novartis Investigative Site
  - Béziers, Frankrike, 34525
    - Novartis Investigative Site
  - Chambray-lès-Tours, Frankrike, 37170
    - Novartis Investigative Site
  - Cholet, Frankrike, 49325
    - Novartis Investigative Site
  - Clermont-Ferrand, Frankrike, 63003
    - Novartis Investigative Site
  - Corbeil-Essonnes, Frankrike, 91100
    - Novartis Investigative Site
  - Grenoble, Frankrike, 38043
    - Novartis Investigative Site
  - Le Coudray, Frankrike, 28630
    - Novartis Investigative Site
  - Lille, Frankrike, 59000
    - Novartis Investigative Site
  - Lyon, Frankrike, 69007
    - Novartis Investigative Site
  - Marseille, Frankrike, 13885
    - Novartis Investigative Site
  - Metz, Frankrike, 57085
    - Novartis Investigative Site
  - Montauban, Frankrike, 82017
    - Novartis Investigative Site
  - Montpellier, Frankrike, 34295
    - Novartis Investigative Site
  - Nice, Frankrike, 06000
    - Novartis Investigative Site
  - Nîmes, Frankrike, 30029
    - Novartis Investigative Site
  - Orléans, Frankrike, 45100
    - Novartis Investigative Site
  - Paris, Frankrike, 75013
    - Novartis Investigative Site
  - Paris, Frankrike, 75015
    - Novartis Investigative Site
  - Paris, Frankrike, 75010
    - Novartis Investigative Site
  - Paris, Frankrike, 75018
    - Novartis Investigative Site
  - Pau, Frankrike, 64046
    - Novartis Investigative Site
  - Pessac, Frankrike, 33604
    - Novartis Investigative Site
  - Poitiers, Frankrike, 86021
    - Novartis Investigative Site
  - Reims, Frankrike, 51092
    - Novartis Investigative Site
  - Rennes, Frankrike, 35033
    - Novartis Investigative Site
  - Toulouse, Frankrike, 31054
    - Novartis Investigative Site
  - Tourcoing, Frankrike, 59208
    - Novartis Investigative Site
  - Valenciennes, Frankrike, 59300
    - Novartis Investigative Site
  - Villeneuve-d'Ascq, Frankrike, 59650
    - Novartis Investigative Site
- Haute Vienne
  - Limoges, Haute Vienne, Frankrike, 87000
    - Novartis Investigative Site
Hellas
- - Athens, Hellas, 115 27
    - Novartis Investigative Site
  - Athens, Hellas, 115 21
    - Novartis Investigative Site
  - Athens, Hellas, 11528
    - Novartis Investigative Site
  - Ioannina, Hellas, 455 00
    - Novartis Investigative Site
  - Larissa, Hellas, 411 10
    - Novartis Investigative Site
  - Thessaloniki, Hellas, 570 01
    - Novartis Investigative Site
India
- - Mysore, India, 570015
    - Novartis Investigative Site
  - New Delhi, India, 110025
    - Novartis Investigative Site
  - Puducherry, India, 607402
    - Novartis Investigative Site
  - Uttarakhand, India, 263153
    - Novartis Investigative Site
- Andhra Pradesh
  - Guntur, Andhra Pradesh, India, 522001
    - Novartis Investigative Site
  - Hyderabad, Andhra Pradesh, India, 500033
    - Novartis Investigative Site
- Gujarat
  - Ahmedabad, Gujarat, India, 382428
    - Novartis Investigative Site
  - Ahmedabad, Gujarat, India, 380054
    - Novartis Investigative Site
  - Ahmedabad, Gujarat, India, 380060
    - Novartis Investigative Site
  - Vadodara, Gujarat, India, 390022
    - Novartis Investigative Site
- Karnataka
  - Belagavi, Karnataka, India, 590010
    - Novartis Investigative Site
  - Manipal, Karnataka, India, 576104
    - Novartis Investigative Site
  - Mysore, Karnataka, India, 570001
    - Novartis Investigative Site
- Kerala
  - Kochi, Kerala, India, 682041
    - Novartis Investigative Site
  - Kochi, Kerala, India, 682018
    - Novartis Investigative Site
  - Kozhikode, Kerala, India, 673008
    - Novartis Investigative Site
- Madhyapradesh
  - Indore, Madhyapradesh, India, 452003
    - Novartis Investigative Site
- Maharashtra
  - Mumbai, Maharashtra, India, 400012
    - Novartis Investigative Site
  - Nagpur, Maharashtra, India, 440012
    - Novartis Investigative Site
  - Nagpur, Maharashtra, India, 440033
    - Novartis Investigative Site
  - Nashik, Maharashtra, India, 422005
    - Novartis Investigative Site
  - Pune, Maharashtra, India, 411004
    - Novartis Investigative Site
  - Pune, Maharashtra, India, 411045
    - Novartis Investigative Site
- National Capital Territory of Delhi
  - New Delhi, National Capital Territory of Delhi, India, 110060
    - Novartis Investigative Site
  - New Delhi, National Capital Territory of Delhi, India, 110076
    - Novartis Investigative Site
  - New Delhi, National Capital Territory of Delhi, India, 110075
    - Novartis Investigative Site
- Rajasthan
  - Bikaner, Rajasthan, India, 334003
    - Novartis Investigative Site
- Tamil Nadu
  - Chennai, Tamil Nadu, India, 600006
    - Novartis Investigative Site
  - Coimbatore, Tamil Nadu, India, 641037
    - Novartis Investigative Site
  - Coimbatore, Tamil Nadu, India, 641009
    - Novartis Investigative Site
  - Madurai, Tamil Nadu, India, 625020
    - Novartis Investigative Site
- Telangana
  - Hyderabad, Telangana, India, 500034
    - Novartis Investigative Site
  - Secunderabad, Telangana, India, 500003
    - Novartis Investigative Site
- Uttar Pradesh
  - Aligarh, Uttar Pradesh, India, 202002
    - Novartis Investigative Site
  - Ghaziabad, Uttar Pradesh, India, 201012
    - Novartis Investigative Site
  - Kanpur, Uttar Pradesh, India, 208002
    - Novartis Investigative Site
  - Lucknow, Uttar Pradesh, India, 226003
    - Novartis Investigative Site
  - Varanasi, Uttar Pradesh, India, 221010
    - Novartis Investigative Site
- Uttarakhand
  - Dehradun, Uttarakhand, India, 248001
    - Novartis Investigative Site
- Uttrakhand
  - Dehradun, Uttrakhand, India, 248104
    - Novartis Investigative Site
- West Bengal
  - Kolkata, West Bengal, India, 700054
    - Novartis Investigative Site
Island
- - Kopavogur, Island, 201
    - Novartis Investigative Site
  - Reykjavik, Island, 101
    - Novartis Investigative Site
Israel
- - Ashdod, Israel, 7747629
    - Novartis Investigative Site
  - Holon, Israel, 5822012
    - Novartis Investigative Site
  - Jerusalem, Israel, 9112001
    - Novartis Investigative Site
  - Nahariya, Israel, 2210001
    - Novartis Investigative Site
  - Petah Tikva, Israel, 4941492
    - Novartis Investigative Site
  - Ramat Gan, Israel, 5265601
    - Novartis Investigative Site
  - Sefad, Israel, 1311300
    - Novartis Investigative Site
  - Ẕerifin, Israel, 7030000
    - Novartis Investigative Site
Italia
- BO
  - Bologna, BO, Italia, 40138
    - Novartis Investigative Site
  - Bologna, BO, Italia, 40133
    - Novartis Investigative Site
- BS
  - Brescia, BS, Italia, 25123
    - Novartis Investigative Site
- FE
  - Cona, FE, Italia, 44124
    - Novartis Investigative Site
- FI
  - Florence, FI, Italia, 50134
    - Novartis Investigative Site
- GR
  - Grosseto, GR, Italia, 58100
    - Novartis Investigative Site
- IS
  - Pozzilli, IS, Italia, 86077
    - Novartis Investigative Site
- MI
  - Milan, MI, Italia, 20162
    - Novartis Investigative Site
  - Milan, MI, Italia, 20132
    - Novartis Investigative Site
  - Milan, MI, Italia, 20138
    - Novartis Investigative Site
  - Rozzano, MI, Italia, 20089
    - Novartis Investigative Site
- MO
  - Modena, MO, Italia, 41126
    - Novartis Investigative Site
- PN
  - Pordenone, PN, Italia, 33170
    - Novartis Investigative Site
- SI
  - Siena, SI, Italia, 53100
    - Novartis Investigative Site
- SS
  - Sassari, SS, Italia, 07100
    - Novartis Investigative Site
- TO
  - Torino, TO, Italia, 10126
    - Novartis Investigative Site
Japan
- - Nagasaki, Japan, 8508555
    - Novartis Investigative Site
- Aichi-ken
  - Toyota, Aichi-ken, Japan, 4718513
    - Novartis Investigative Site
- Fukuka
  - Chikushino-shi, Fukuka, Japan, 8188516
    - Novartis Investigative Site
- Ishikawa-ken
  - Kanazawa, Ishikawa-ken, Japan, 9208650
    - Novartis Investigative Site
  - Komatsu, Ishikawa-ken, Japan, 9230961
    - Novartis Investigative Site
- Kanagawa
  - Fujisawa, Kanagawa, Japan, 2518550
    - Novartis Investigative Site
  - Odawara, Kanagawa, Japan, 2508558
    - Novartis Investigative Site
  - Yokohama, Kanagawa, Japan, 2478581
    - Novartis Investigative Site
- Niigata
  - Nagaoka, Niigata, Japan, 9408621
    - Novartis Investigative Site
- Osaka
  - Izumisano, Osaka, Japan, 5988577
    - Novartis Investigative Site
  - Osaka, Osaka, Japan, 5400006
    - Novartis Investigative Site
- Saitama
  - Kawaguchi, Saitama, Japan, 3328558
    - Novartis Investigative Site
Kenya
- - Nairobi, Kenya, 00200
    - Novartis Investigative Site
Kina
- - Beijing, Kina, 100029
    - Novartis Investigative Site
  - Beijing, Kina, 100034
    - Novartis Investigative Site
  - Beijing, Kina, 100050
    - Novartis Investigative Site
  - Beijing, Kina, 100191
    - Novartis Investigative Site
  - Beijing, Kina, 100039
    - Novartis Investigative Site
  - Chongqing, Kina, 400016
    - Novartis Investigative Site
  - Guangzhou, Kina, 510000
    - Novartis Investigative Site
  - Guangzhou, Kina, 510280
    - Novartis Investigative Site
  - Jinan, Kina, 250012
    - Novartis Investigative Site
  - Shanghai, Kina, 200080
    - Novartis Investigative Site
  - Shanghai, Kina, 200032
    - Novartis Investigative Site
  - Shanghai, Kina, 200025
    - Novartis Investigative Site
  - Shanghai, Kina, 200040
    - Novartis Investigative Site
  - Tianjin, Kina, 300140
    - Novartis Investigative Site
  - Xiamen, Kina, 361004
    - Novartis Investigative Site
- Beijing Municipality
  - Beijing, Beijing Municipality, Kina, 100013
    - Novartis Investigative Site
- Guangdong
  - Foshan, Guangdong, Kina, 528000
    - Novartis Investigative Site
  - Guangzhou, Guangdong, Kina, 510080
    - Novartis Investigative Site
  - Guangzhou, Guangdong, Kina, 510515
    - Novartis Investigative Site
- Guangxi
  - Nanning, Guangxi, Kina, 530022
    - Novartis Investigative Site
- Heilongjiang
  - Harbin, Heilongjiang, Kina, 150000
    - Novartis Investigative Site
- Hubei
  - Jingzhou, Hubei, Kina, 434020
    - Novartis Investigative Site
  - Wuhan, Hubei, Kina, 430060
    - Novartis Investigative Site
  - Wuhan, Hubei, Kina, 430022
    - Novartis Investigative Site
  - Wuhan, Hubei, Kina, 430014
    - Novartis Investigative Site
- Hunan
  - Changsha, Hunan, Kina, 410011
    - Novartis Investigative Site
  - Changsha, Hunan, Kina, 410003
    - Novartis Investigative Site
- Inner Mongolia
  - Hohhot, Inner Mongolia, Kina, 010017
    - Novartis Investigative Site
- Jiangsu
  - Changzhou, Jiangsu, Kina, 213004
    - Novartis Investigative Site
  - Jiangyin, Jiangsu, Kina, 214499
    - Novartis Investigative Site
  - Nanjing, Jiangsu, Kina, 210008
    - Novartis Investigative Site
  - Nanjing, Jiangsu, Kina, 210009
    - Novartis Investigative Site
  - Nanjing, Jiangsu, Kina, 211166
    - Novartis Investigative Site
  - Suzhou, Jiangsu, Kina, 215004
    - Novartis Investigative Site
  - Xuzhou, Jiangsu, Kina, 221003
    - Novartis Investigative Site
- Jiangxi
  - Nanchang, Jiangxi, Kina, 330006
    - Novartis Investigative Site
  - Pingxiang, Jiangxi, Kina, 337000
    - Novartis Investigative Site
- Jilin
  - Changchun, Jilin, Kina, 130000
    - Novartis Investigative Site
- Liaoning
  - Dalian, Liaoning, Kina, 116011
    - Novartis Investigative Site
  - Shenyang, Liaoning, Kina, 110004
    - Novartis Investigative Site
- Shandong
  - Jinan, Shandong, Kina, 250013
    - Novartis Investigative Site
- Shanxi
  - Taiyuan, Shanxi, Kina, 030002
    - Novartis Investigative Site
  - Xian, Shanxi, Kina, 710061
    - Novartis Investigative Site
- Sichuan
  - Chengdu, Sichuan, Kina, 610041
    - Novartis Investigative Site
- Tianjin Municipality
  - Tianjin, Tianjin Municipality, Kina, 300121
    - Novartis Investigative Site
- Xinjiang
  - Ürümqi, Xinjiang, Kina, 830001
    - Novartis Investigative Site
  - Ürümqi, Xinjiang, Kina, 830054
    - Novartis Investigative Site
- Zhejiang
  - Hangzhou, Zhejiang, Kina, 310016
    - Novartis Investigative Site
  - Lishui, Zhejiang, Kina, 323020
    - Novartis Investigative Site
  - Taizhou, Zhejiang, Kina, 318000
    - Novartis Investigative Site
Kroatia
- - Krapinske Toplice, Kroatia, 49217
    - Novartis Investigative Site
  - Opatija, Kroatia, 51410
    - Novartis Investigative Site
  - Osijek, Kroatia, 31000
    - Novartis Investigative Site
  - Rijeka, Kroatia, 51000
    - Novartis Investigative Site
  - Slavonski Brod, Kroatia, 35000
    - Novartis Investigative Site
  - Split, Kroatia, 21000
    - Novartis Investigative Site
  - Zagreb, Kroatia, 10000
    - Novartis Investigative Site
  - Čakovec, Kroatia, 40000
    - Novartis Investigative Site
Latvia
- - Daugavpils, Latvia, LV-5417
    - Novartis Investigative Site
  - Kuldīga, Latvia, LV-3300
    - Novartis Investigative Site
  - Riga, Latvia, LV 1002
    - Novartis Investigative Site
  - Riga, Latvia, 1012
    - Novartis Investigative Site
  - Riga, Latvia, LV-1001
    - Novartis Investigative Site
  - Valmiera, Latvia, 4201
    - Novartis Investigative Site
- LV
  - Liepāja, LV, Latvia, LV-3414
    - Novartis Investigative Site
  - Riga, LV, Latvia, 1038
    - Novartis Investigative Site
Litauen
- - Kaunas, Litauen, LT-50009
    - Novartis Investigative Site
  - Kaunas, Litauen, 49449
    - Novartis Investigative Site
  - Panevezys, Litauen, 35144
    - Novartis Investigative Site
  - Vilnius, Litauen, LT-08406
    - Novartis Investigative Site
  - Šiauliai, Litauen, 76206
    - Novartis Investigative Site
- Kaunas County
  - Kaunas, Kaunas County, Litauen, LT-50177
    - Novartis Investigative Site
- Klaipėda County
  - Klaipėda, Klaipėda County, Litauen, 92288
    - Novartis Investigative Site
- LTU
  - Kaunas, LTU, Litauen, LT 50161
    - Novartis Investigative Site
  - Šiauliai, LTU, Litauen, LT-77156
    - Novartis Investigative Site
Malaysia
- - Kuala Lumpur, Malaysia, 59100
    - Novartis Investigative Site
  - Kuala Lumpur, Malaysia, 56000
    - Novartis Investigative Site
- Kedah
  - Alor Star, Kedah, Malaysia, 05460
    - Novartis Investigative Site
- Pahang
  - Kuantan, Pahang, Malaysia, 25100
    - Novartis Investigative Site
- Perak
  - Ipoh, Perak, Malaysia, 30450
    - Novartis Investigative Site
- Selangor
  - Kuala Lumpur, Selangor, Malaysia, 43000
    - Novartis Investigative Site
Mauritius
- - Phoenix, Mauritius, 73408
    - Novartis Investigative Site
- Mauritius
  - Solferino Phoenix, Mauritius, Mauritius, 1772
    - Novartis Investigative Site
Mexico
- - Acapulco, Mexico, 39570
    - Novartis Investigative Site
  - Aguascalientes, Mexico, 20230
    - Novartis Investigative Site
  - Chihuahua City, Mexico, 31203
    - Novartis Investigative Site
  - Durango, Mexico, 34000
    - Novartis Investigative Site
  - Guadalajara, Mexico, 44360
    - Novartis Investigative Site
  - Xalapa, Mexico, 91020
    - Novartis Investigative Site
  - Xalapa, Mexico, 91193
    - Novartis Investigative Site
- Jalisco
  - Guadalajara, Jalisco, Mexico, 44670
    - Novartis Investigative Site
  - Guadalajara, Jalisco, Mexico, 44600
    - Novartis Investigative Site
  - Guadalajara, Jalisco, Mexico, 44210
    - Novartis Investigative Site
- Mexico City
  - Mexico City, Mexico City, Mexico, 06700
    - Novartis Investigative Site
- Nuevo León
  - Monterrey, Nuevo León, Mexico, 64710
    - Novartis Investigative Site
- State of Mexico
  - Tlalnepantla, State of Mexico, Mexico, 54055
    - Novartis Investigative Site
- Yucatán
  - Mérida, Yucatán, Mexico, 97070
    - Novartis Investigative Site
Nederland
- - Amersfoort, Nederland, 3813 TZ
    - Novartis Investigative Site
  - Gouda, Nederland, 2803 HH
    - Novartis Investigative Site
  - Groningen, Nederland, 9713 GZ
    - Novartis Investigative Site
  - Groningen, Nederland, 9728 NZ
    - Novartis Investigative Site
  - Nijmegen, Nederland, 6525 GA
    - Novartis Investigative Site
  - Venlo, Nederland, 5912 BL
    - Novartis Investigative Site
- Drenthe
  - Meppel, Drenthe, Nederland, 7943 KC
    - Novartis Investigative Site
- Gelderland
  - Doetinchem, Gelderland, Nederland, 7009 BL
    - Novartis Investigative Site
  - Tiel, Gelderland, Nederland, 4002 WP
    - Novartis Investigative Site
- Gerlderland
  - Nijmegen, Gerlderland, Nederland, 6532 SZ
    - Novartis Investigative Site
- North Brabant
  - Breda, North Brabant, Nederland, 4818 CK
    - Novartis Investigative Site
  - Tilburg, North Brabant, Nederland, 5042 AD
    - Novartis Investigative Site
- North Holland
  - Alkmaar, North Holland, Nederland, 1815 JD
    - Novartis Investigative Site
  - Amstelveen, North Holland, Nederland, 1186 AM
    - Novartis Investigative Site
  - Amsterdam, North Holland, Nederland, 1090 HM
    - Novartis Investigative Site
  - Amsterdam, North Holland, Nederland, 1105 AZ
    - Novartis Investigative Site
  - Heemstede, North Holland, Nederland, 2035 RC
    - Novartis Investigative Site
- Overijssel
  - Deventer, Overijssel, Nederland, 7416 SE
    - Novartis Investigative Site
- Provincie Friesland
  - Leeuwarden, Provincie Friesland, Nederland, 8934 AD
    - Novartis Investigative Site
  - Sneek, Provincie Friesland, Nederland, 8601 ZK
    - Novartis Investigative Site
- South Holland
  - Leiden, South Holland, Nederland, 2333 ZA
    - Novartis Investigative Site
  - Leiderdorp, South Holland, Nederland, 2353 GA
    - Novartis Investigative Site
New Zealand
- - Auckland, New Zealand, 0740
    - Novartis Investigative Site
  - Christchurch, New Zealand, 8001
    - Novartis Investigative Site
  - Christchurch, New Zealand, 8140
    - Novartis Investigative Site
  - Hamilton, New Zealand, 3204
    - Novartis Investigative Site
  - Lower Hutt, New Zealand, 5040
    - Novartis Investigative Site
- Auckland
  - Grafton, Auckland, New Zealand, 1023
    - Novartis Investigative Site
- NZW
  - Dunedin, NZW, New Zealand, 9016
    - Novartis Investigative Site
Norge
- - Arendal, Norge, 4838
    - Novartis Investigative Site
  - Drammen, Norge, 3004
    - Novartis Investigative Site
  - Oslo, Norge, 0407
    - Novartis Investigative Site
  - Oslo, Norge, 0514
    - Novartis Investigative Site
  - Skedsmokorset, Norge, 2020
    - Novartis Investigative Site
  - Stavanger, Norge, 4019
    - Novartis Investigative Site
  - Tromsø, Norge, 9038
    - Novartis Investigative Site
- Oslo
  - Nordbyhagen, Oslo, Norge, 1478
    - Novartis Investigative Site
Polen
- - Bialystok, Polen, 15-540
    - Novartis Investigative Site
  - Bialystok, Polen, 15-481
    - Novartis Investigative Site
  - Bydgoszcz, Polen, 85-065
    - Novartis Investigative Site
  - Gdansk, Polen, 80-952
    - Novartis Investigative Site
  - Gdynia, Polen, 81-423
    - Novartis Investigative Site
  - Kielce, Polen, 25-525
    - Novartis Investigative Site
  - Krakow, Polen, 31-501
    - Novartis Investigative Site
  - Krakow, Polen, 30-082
    - Novartis Investigative Site
  - Krakow, Polen, 30-363
    - Novartis Investigative Site
  - Kłodzko, Polen, 57-300
    - Novartis Investigative Site
  - Lodz, Polen, 93-513
    - Novartis Investigative Site
  - Lublin, Polen, 20-068
    - Novartis Investigative Site
  - Olsztyn, Polen, 10-165
    - Novartis Investigative Site
  - Ostrowiec Swietok, Polen, 27-400
    - Novartis Investigative Site
  - Puławy, Polen, 24-100
    - Novartis Investigative Site
  - Ruda Śląska, Polen, 41-710
    - Novartis Investigative Site
  - Skierniewice, Polen, 96-100
    - Novartis Investigative Site
  - Torun, Polen, 87-100
    - Novartis Investigative Site
  - Warsaw, Polen, 04-073
    - Novartis Investigative Site
  - Wroclaw, Polen, 53-673
    - Novartis Investigative Site
  - Włocławek, Polen, 87-800
    - Novartis Investigative Site
  - Zamość, Polen, 22-400
    - Novartis Investigative Site
- Lesser Poland Voivodeship
  - Nowy Targ, Lesser Poland Voivodeship, Polen, 34-400
    - Novartis Investigative Site
- Masovian Voivodeship
  - Ostrołęka, Masovian Voivodeship, Polen, 07-410
    - Novartis Investigative Site
- Silesian Voivodeship
  - Sosnowiec, Silesian Voivodeship, Polen, 41-219
    - Novartis Investigative Site
Portugal
- - Alcabideche, Portugal, 2755-009
    - Novartis Investigative Site
  - Almada, Portugal, 2805-267
    - Novartis Investigative Site
  - Carnaxide, Portugal, 2799-523
    - Novartis Investigative Site
  - Coimbra, Portugal, 3004-561
    - Novartis Investigative Site
  - Guimarães, Portugal, 4835-044
    - Novartis Investigative Site
  - Leiria, Portugal, 2410-197
    - Novartis Investigative Site
  - Lisbon, Portugal, 1649-035
    - Novartis Investigative Site
  - Lisbon, Portugal, 1500-650
    - Novartis Investigative Site
  - Matosinhos Municipality, Portugal, 4454-513
    - Novartis Investigative Site
  - Santa Maria da Feira, Portugal, 4520-211
    - Novartis Investigative Site
  - Vila Nova de Gaia, Portugal, 4434-502
    - Novartis Investigative Site
  - Vila Real, Portugal, 5000-508
    - Novartis Investigative Site
Puerto Rico
- - Bayamón, Puerto Rico, 00959
    - Advanced Clinical Research LLC
  - Ponce, Puerto Rico, 00717-1322
    - Research and Cardiovascular Corp
  - San Juan, Puerto Rico, 00926
    - Advance Medical Research Center
  - San Juan, Puerto Rico, 00909
    - Latin Clinical Trial Center Inc
  - San Juan, Puerto Rico, 00926
    - Barbara Diaz Hernandez Research Inc
Romania
- - Brasov, Romania, 500283
    - Novartis Investigative Site
  - Bucharest, Romania, 022328
    - Novartis Investigative Site
  - Bucharest, Romania, 050098
    - Novartis Investigative Site
  - Bucharest, Romania, 011461
    - Novartis Investigative Site
  - Bucharest, Romania, 021875
    - Novartis Investigative Site
  - Bucharest, Romania, 011025
    - Novartis Investigative Site
  - Caracal, Romania, 235200
    - Novartis Investigative Site
  - Craiova, Romania, 200642
    - Novartis Investigative Site
  - Iași, Romania, 700503
    - Novartis Investigative Site
  - Oradea, Romania, 410169
    - Novartis Investigative Site
  - Timișoara, Romania, 300079
    - Novartis Investigative Site
  - Timișoara, Romania, 300359
    - Novartis Investigative Site
  - Târgu Mureş, Romania, 540143
    - Novartis Investigative Site
- Argeş
  - Piteşti, Argeş, Romania, 110424
    - Novartis Investigative Site
- Maramureş
  - Baia Mare, Maramureş, Romania, 430123
    - Novartis Investigative Site
- Mureș County
  - Târgu Mureş, Mureș County, Romania, 540124
    - Novartis Investigative Site
- ROM
  - Brăila, ROM, Romania, 810249
    - Novartis Investigative Site
- Timiș County
  - Timișoara, Timiș County, Romania, 300041
    - Novartis Investigative Site
  - Timișoara, Timiș County, Romania, 300480
    - Novartis Investigative Site
Russland
- - Moscow, Russland, 127473
    - Novartis Investigative Site
  - Ryazan, Russland, 390039
    - Novartis Investigative Site
  - Saint Petersburg, Russland, 195197
    - Novartis Investigative Site
  - Yaroslavl, Russland, 150062
    - Novartis Investigative Site
Serbia
- - Belgrade, Serbia, 11000
    - Novartis Investigative Site
  - Belgrade, Serbia, 11070
    - Novartis Investigative Site
  - Belgrade, Serbia, 11080
    - Novartis Investigative Site
  - Kamenitz, Serbia, 21204
    - Novartis Investigative Site
  - Kragujevac, Serbia, 34000
    - Novartis Investigative Site
  - Leskovac, Serbia, 16000
    - Novartis Investigative Site
  - Niš, Serbia, 18000
    - Novartis Investigative Site
  - Smederevo, Serbia, 26000
    - Novartis Investigative Site
  - Subotica, Serbia, 24000
    - Novartis Investigative Site
  - Vranje, Serbia, 17500
    - Novartis Investigative Site
  - Zaječar, Serbia, 19000
    - Novartis Investigative Site
  - Ćuprija, Serbia, 35230
    - Novartis Investigative Site
Singapore
- - Singapore, Singapore, 119074
    - Novartis Investigative Site
  - Singapore, Singapore, 529889
    - Novartis Investigative Site
  - Singapore, Singapore, 169609
    - Novartis Investigative Site
  - Singapore, Singapore, 768828
    - Novartis Investigative Site
Slovakia
- - Banská Bystrica, Slovakia, 974 01
    - Novartis Investigative Site
  - Bardejov, Slovakia, 085 01
    - Novartis Investigative Site
  - Bratislava, Slovakia, 826 06
    - Novartis Investigative Site
  - Bratislava, Slovakia, 831 06
    - Novartis Investigative Site
  - Bratislava, Slovakia, 833 48
    - Novartis Investigative Site
  - Bratislava, Slovakia, 851 01
    - Novartis Investigative Site
  - Bratislava, Slovakia, 813 69
    - Novartis Investigative Site
  - Bratislava, Slovakia, 841 08
    - Novartis Investigative Site
  - Košice, Slovakia, 040 01
    - Novartis Investigative Site
  - Košice, Slovakia, 040 22
    - Novartis Investigative Site
  - Lučenec, Slovakia, 984 01
    - Novartis Investigative Site
  - Moldava nad Bodvou, Slovakia, 045 01
    - Novartis Investigative Site
  - Nitra, Slovakia, 949 01
    - Novartis Investigative Site
  - Nitra, Slovakia, 949 11
    - Novartis Investigative Site
  - Nové Zámky, Slovakia, 940 01
    - Novartis Investigative Site
  - Piešťany, Slovakia, 921 01
    - Novartis Investigative Site
  - Považská Bystrica, Slovakia, 017 01
    - Novartis Investigative Site
  - Prešov, Slovakia, 080 01
    - Novartis Investigative Site
  - Rožňava, Slovakia, 048 01
    - Novartis Investigative Site
  - Žilina, Slovakia, 010 01
    - Novartis Investigative Site
Slovenia
- - Celje, Slovenia, 3000
    - Novartis Investigative Site
  - Ljubljana, Slovenia, 1000
    - Novartis Investigative Site
  - Ptuj, Slovenia, 2250
    - Novartis Investigative Site
  - Slovenj Gradec, Slovenia, 2380
    - Novartis Investigative Site
Spania
- - A Coruña, Spania, 15006
    - Novartis Investigative Site
  - A Coruña, Spania, 15001
    - Novartis Investigative Site
  - Alicante, Spania, 03700
    - Novartis Investigative Site
  - Almería, Spania, 04009
    - Novartis Investigative Site
  - Barcelona, Spania, 08035
    - Novartis Investigative Site
  - Barcelona, Spania, 08036
    - Novartis Investigative Site
  - Barcelona, Spania, 08041
    - Novartis Investigative Site
  - Barcelona, Spania, 08025
    - Novartis Investigative Site
  - Barcelona, Spania, 08023
    - Novartis Investigative Site
  - Córdoba, Spania, 14004
    - Novartis Investigative Site
  - Granada, Spania, 18016
    - Novartis Investigative Site
  - Huelva, Spania, 21080
    - Novartis Investigative Site
  - Las Palmas GC, Spania, 35010
    - Novartis Investigative Site
  - Madrid, Spania, 28041
    - Novartis Investigative Site
  - Madrid, Spania, 28034
    - Novartis Investigative Site
  - Madrid, Spania, 28046
    - Novartis Investigative Site
  - Madrid, Spania, 28006
    - Novartis Investigative Site
  - Madrid, Spania, 28040
    - Novartis Investigative Site
  - Madrid, Spania, 28009
    - Novartis Investigative Site
  - Madrid, Spania, 28003
    - Novartis Investigative Site
  - Málaga, Spania, 29010
    - Novartis Investigative Site
  - Salamanca, Spania, 37007
    - Novartis Investigative Site
  - Salamanca, Spania, 37005
    - Novartis Investigative Site
  - Seville, Spania, 41009
    - Novartis Investigative Site
  - Seville, Spania, 41013
    - Novartis Investigative Site
  - Valencia, Spania, 46014
    - Novartis Investigative Site
  - Valencia, Spania, 46010
    - Novartis Investigative Site
  - Valladolid, Spania, 47011
    - Novartis Investigative Site
  - Zaragoza, Spania, 50009
    - Novartis Investigative Site
- A Coruna
  - Ferrol, A Coruna, Spania, 15405
    - Novartis Investigative Site
  - Santiago Compostela, A Coruna, Spania, 15706
    - Novartis Investigative Site
- Andalusia
  - Seville, Andalusia, Spania, 41014
    - Novartis Investigative Site
- Balearic Islands
  - Mallorca, Balearic Islands, Spania, 07198
    - Novartis Investigative Site
  - Palma, Balearic Islands, Spania, 07120
    - Novartis Investigative Site
- Barcelona
  - L'Hospitalet de Llobregat, Barcelona, Spania, 08907
    - Novartis Investigative Site
  - Sabadell, Barcelona, Spania, 08208
    - Novartis Investigative Site
  - Sant Joan Despí, Barcelona, Spania, 08970
    - Novartis Investigative Site
  - el Prat de Llobregat, Barcelona, Spania, 08820
    - Novartis Investigative Site
- Bizkaia
  - Bilbao, Bizkaia, Spania, 48013
    - Novartis Investigative Site
- Cadiz
  - Jerez de la Frontera, Cadiz, Spania, 11407
    - Novartis Investigative Site
  - Villamartín, Cadiz, Spania, 11650
    - Novartis Investigative Site
- Cantabria
  - Santander, Cantabria, Spania, 39008
    - Novartis Investigative Site
- Madrid
  - Alcorcón, Madrid, Spania, 28922
    - Novartis Investigative Site
  - San Sebastian Reyes, Madrid, Spania, 28702
    - Novartis Investigative Site
- Murcia
  - El Palmar, Murcia, Spania, 30120
    - Novartis Investigative Site
- Pontevedra
  - Vigo, Pontevedra, Spania, 36212
    - Novartis Investigative Site
- Sevilla
  - Utrera, Sevilla, Spania, 41710
    - Novartis Investigative Site
- Tarragona
  - Reus, Tarragona, Spania, 43204
    - Novartis Investigative Site
Sverige
- - Falun, Sverige, 791 82
    - Novartis Investigative Site
  - Gothenburg, Sverige, 412 55
    - Novartis Investigative Site
  - Lund, Sverige, 221 85
    - Novartis Investigative Site
  - Malmö, Sverige, 214 28
    - Novartis Investigative Site
  - Stockholm, Sverige, 111 57
    - Novartis Investigative Site
  - Stockholm, Sverige, 17176
    - Novartis Investigative Site
  - Västerås, Sverige, 721 89
    - Novartis Investigative Site
- SE
  - Stockholm, SE, Sverige, 141 86
    - Novartis Investigative Site
- Västra Götaland County
  - Gothenburg, Västra Götaland County, Sverige, 416 85
    - Novartis Investigative Site
Sør -Korea
- - Busan, Sør -Korea, 49201
    - Novartis Investigative Site
  - Daegu, Sør -Korea, 705703
    - Novartis Investigative Site
  - Daejeon, Sør -Korea, 302-241
    - Novartis Investigative Site
  - Gwangju, Sør -Korea, 61469
    - Novartis Investigative Site
  - Seoul, Sør -Korea, 03080
    - Novartis Investigative Site
  - Seoul, Sør -Korea, 03722
    - Novartis Investigative Site
  - Seoul, Sør -Korea, 06351
    - Novartis Investigative Site
  - Seoul, Sør -Korea, 06591
    - Novartis Investigative Site
- Dalseo Gu
  - Daegu, Dalseo Gu, Sør -Korea, 42602
    - Novartis Investigative Site
- Gangwon-do
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Taiwan
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Thailand
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Tsjekkia
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Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

40 år og eldre (Voksen, Eldre voksen)

Tar imot friske frivillige

Nei

Beskrivelse

Inklusjonskriterier:

Fastende LDL-C ≥ 70 mg/dL ved randomiseringsbesøk
Stabilt (større enn eller lik 4 uker) og godt tolerert lipidsenkende regime (inkludert f.eks. med eller uten Ezetimibe) som må inkludere en høyintensiv statinbehandling med enten atorvastatin større enn eller lik 40 mg QD eller rosuvastatin større enn eller lik 20 mg QD
Etablert CV-sykdom definert som EN av de følgende tre tilstandene
1. Spontant hjerteinfarkt ≥ 4 uker fra screeningbesøk
2. Anamnese med iskemisk hjerneslag forekom ≥ 4 uker før screeningbesøket
3. Symptomatisk perifer arteriell sykdom (PAD) påvist ved enten claudicatio intermittens med ankelbrachial indeks (ABI) < 0,85, tidligere perifer arteriell revaskulariseringsprosedyre, eller amputasjon på grunn av aterosklerotisk sykdom.

Ekskluderingskriterier:

Akutt koronarsyndrom, hjerneslag, perifer arteriell revaskulariseringsprosedyre eller amputasjon på grunn av aterosklerotisk sykdom < 4 uker før screeningbesøk
Behandling med PCSK9-hemmere (f. evolocumab, alirocumab) innen 90 dager eller planlagt bruk etter første studiebesøk
Planlagt eller forventet hjerte-, cerebrovaskulær eller perifer arteriekirurgi eller re-vaskularisering innen 6 måneder etter det første studiebesøket
Hjertesvikt NYHA klasse III eller IV
Aktiv leversykdom definert som enhver kjent nåværende smittsom, neoplastisk eller metabolsk patologi i leveren
Tidligere eksponering for inclisiran eller annen ikke-mAb PCSK9-målrettet behandling, enten som et forsøks- eller markedsført legemiddel innen 2 år
Alvorlig samtidig ikke-CV-sykdom som forventes å redusere forventet levealder til mindre enn 5 år
Anamnese med malignitet som krevde kirurgisk strålebehandling og/eller systemisk terapi i løpet av de 3 årene før det første studiebesøket
Gravide eller ammende (ammende) kvinner

Andre protokolldefinerte inkluderings-/ekskluderingskriterier kan gjelde.

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

Primært formål: Behandling
Tildeling: Randomisert
Intervensjonsmodell: Parallell tildeling
Masking: Dobbelt

Antall våpen

Våpen og intervensjoner

Deltakergruppe / Arm	Intervensjon / Behandling
Placebo komparator: Placebo Subkutan injeksjon	Legemiddel: Placebo Subkutant injisert på dag 1, måned 3 (dag 90) og hver 6. måned deretter frem til EOS-besøk
Eksperimentell: Inclisiran natrium Subkutan injeksjon	Legemiddel: Inclisiran natrium 300 mg Subkutant injisert på dag 1, måned 3 (dag 90) og hver 6. måned deretter frem til EOS-besøk

Hva måler studien?

Primære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
Tid til første forekomst av 3P-MACE (3-punkts alvorlige kardiovaskulære hendelser) Tidsramme: Fra randomisering til total oppfølgingstid (opptil 72 måneder)	3P-MACE er et bekreftet sammensatt endepunkt som inkluderer kardiovaskulær død, ikke-dødelig hjerteinfarkt og ikke-dødelig iskemisk hjerneslag.	Fra randomisering til total oppfølgingstid (opptil 72 måneder)

Sekundære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
Tid til forekomst av kardiovaskulær (CV) død Tidsramme: Fra randomisering til total oppfølgingstid (opptil 72 måneder)	CV død er definert som død på grunn av kardiovaskulære hendelser	Fra randomisering til total oppfølgingstid (opptil 72 måneder)
Tid til første forekomst av 4P-MACE (4-punkts alvorlige kardiovaskulære hendelser) Tidsramme: Fra randomisering til total oppfølgingstid (opptil 72 måneder)	En sammensatt 4P-MACE er definert som CV-død, ikke-dødelig MI, ikke-dødelig iskemisk hjerneslag og akutt koronar revaskularisering.	Fra randomisering til total oppfølgingstid (opptil 72 måneder)
Tid til forekomst av død av alle årsaker Tidsramme: Fra randomisering til total oppfølgingstid (opptil 72 måneder)	Død av alle årsaker er definert som: alle dødsfall fra randomisering til opptil 72 måneder	Fra randomisering til total oppfølgingstid (opptil 72 måneder)
Tid til første forekomst av alvorlige lembivirkninger (MALE) Tidsramme: Fra randomisering til total oppfølgingstid (opptil 72 måneder)	Større ekstremitetsbivirkninger inkludert akutt iskemi i underekstremiteter, amputasjon av underekstremiteter på grunn av iskemi eller akutt revaskularisering av underekstremiteter for iskemi	Fra randomisering til total oppfølgingstid (opptil 72 måneder)

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

Novartis Pharmaceuticals

Etterforskere

Studieleder: Novartis Pharmaceuticals, Novartis Pharmaceuticals

Publikasjoner og nyttige lenker

Den som er ansvarlig for å legge inn informasjon om studien leverer frivillig disse publikasjonene. Disse kan handle om alt relatert til studiet.

Generelle publikasjoner

Steg PG, Goodman SG, Jukema JW, Martens P, Zirlik A, Bhatt DL, Menon V, Szarek M, Lesogor A, Stratz C, O'Donoghue F, Mena-Madrazo J, Shao Q, Liu K, Mehran R; VICTORION-2 Prevent Investigators. Design of VICTORION-2 Prevent: A randomized double-blind, placebo-controlled trial, assessing the impact of inclisiran on major adverse cardiovascular events in patients with established cardiovascular disease. Am Heart J. 2026 Oct;300:107493. doi: 10.1016/j.ahj.2026.107493. Epub 2026 May 26.

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Faktiske)

23. november 2021

Primær fullføring (Antatt)

10. mai 2027

Studiet fullført (Antatt)

10. mai 2027

Datoer for studieregistrering

Først innsendt

17. august 2021

Først innsendt som oppfylte QC-kriteriene

25. august 2021

Først lagt ut (Faktiske)

1. september 2021

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

25. august 2026

Siste oppdatering sendt inn som oppfylte QC-kriteriene

24. august 2026

Sist bekreftet

1. august 2026

Mer informasjon

Begreper knyttet til denne studien

Nøkkelord

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

CKJX839B12302

Plan for individuelle deltakerdata (IPD)

Planlegger du å dele individuelle deltakerdata (IPD)?

IPD-planbeskrivelse

Novartis er forpliktet til å dele med kvalifiserte eksterne forskere, tilgang til data på pasientnivå og støttende kliniske dokumenter fra kvalifiserte studier. Disse forespørslene vurderes og godkjennes av et uavhengig granskningspanel på grunnlag av vitenskapelig fortjeneste. Alle data som oppgis er anonymisert for å respektere personvernet til pasienter som har deltatt i forsøket i tråd med gjeldende lover og forskrifter.

Denne prøvedatatilgjengeligheten er i henhold til kriteriene og prosessen beskrevet på www.clinicalstudydatarequest.com

Legemiddel- og utstyrsinformasjon, studiedokumenter

Studerer et amerikansk FDA-regulert medikamentprodukt

Studerer et amerikansk FDA-regulert enhetsprodukt

Nei

Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .

Studie av Inclisiran for å forhindre kardiovaskulære (CV) hendelser hos deltakere med etablert kardiovaskulær sykdom (VICTORION-2P)

En randomisert, dobbeltblind, placebokontrollert, multisenterforsøk, som vurderer effekten av Inclisiran på alvorlige uønskede kardiovaskulære hendelser hos deltakere med etablert kardiovaskulær sykdom (VICTORION-2 PREVENT)

Studieoversikt

Status

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

Studietype

Registrering (Faktiske)

Fase

Kontakter og plasseringer

Studiesteder

Deltakelseskriterier

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

Tar imot friske frivillige

Beskrivelse

Studieplan

Hvordan er studiet utformet?

Designdetaljer

Antall våpen

Våpen og intervensjoner

Deltakergruppe / Arm

Intervensjon / Behandling

Hva måler studien?

Primære resultatmål

Resultatmål

Tiltaksbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Tiltaksbeskrivelse

Tidsramme

Samarbeidspartnere og etterforskere

Sponsor

Etterforskere

Publikasjoner og nyttige lenker

Generelle publikasjoner

Studierekorddatoer

Studer hoveddatoer

Studiestart (Faktiske)

Primær fullføring (Antatt)

Studiet fullført (Antatt)

Datoer for studieregistrering

Først innsendt

Først innsendt som oppfylte QC-kriteriene

Først lagt ut (Faktiske)

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

Siste oppdatering sendt inn som oppfylte QC-kriteriene

Sist bekreftet

Mer informasjon

Begreper knyttet til denne studien

Nøkkelord

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

Plan for individuelle deltakerdata (IPD)

Planlegger du å dele individuelle deltakerdata (IPD)?

IPD-planbeskrivelse

Legemiddel- og utstyrsinformasjon, studiedokumenter

Studerer et amerikansk FDA-regulert medikamentprodukt

Studerer et amerikansk FDA-regulert enhetsprodukt