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Udvidet adgangsprogram for Daraxonrasib (RMC-6236) til tidligere behandlet metastatisk pancreascarcinom

27. august 2026 opdateret af: Revolution Medicines, Inc.

Udvidet adgangsprogram til behandling af patienter med tidligere behandlet metastatisk pancreascarcinom med Daraxonrasib

Dette udvidede adgangsprogram (EAP) har til formål at give daraxonrasib til berettigede voksne patienter med tidligere behandlet metastatisk pancreasadenokarcinom, som ikke har nogen sammenlignelig eller tilfredsstillende alternativ behandling og ikke er i stand til at deltage i et igangværende klinisk forsøg med daraxonrasib.

Studieoversigt

Status

Godkendt til markedsføring

Betingelser

Intervention / Behandling

Medicin: "daraxonrasib"

Detaljeret beskrivelse

Dette EAP er blevet etableret for at give adgang til daraxonrasib til patienter med tidligere behandlet metastatisk pancreascarcinom i perioden før potentiel kommerciel tilgængelighed. Patienter kan være berettigede, hvis de har udviklet sig på, er intolerante over for eller ikke længere forventes at have gavn af tilgængelige standardterapier, og hvis de ikke er i stand til at deltage i et klinisk forsøg med daraxonrasib på grund af manglende berettigelse eller manglende adgang. Dette EAP er beregnet til at imødekomme et uopfyldt medicinsk behov og er ikke designet til at understøtte kliniske udviklingsmål.

Daraxonrasib er en forsøgsopskrivningsmiddel, oral administreret RAS(ON)-hæmmer, der administreres som monoterapi. Daraxonrasib leveres af sponsoren uden beregning under behandlingsvarigheden i dette program.

Undersøgelsestype

Udvidet adgang

Udvidet adgangstype

Behandling IND/Protokol

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Forenede Stater
- Alabama
  - Birmingham, Alabama, Forenede Stater, 35243
    - Alabama Oncology
  - Daphne, Alabama, Forenede Stater, 36526
    - Southern Cancer Center
  - Dothan, Alabama, Forenede Stater, 36303
    - Dothan Hematology and Oncology
  - Fort Payne, Alabama, Forenede Stater, 35967
    - Alabama Cancer Care of Ft Payne
  - Mobile, Alabama, Forenede Stater, 36608
    - Southern Cancer Center
  - Mobile, Alabama, Forenede Stater, 36604
    - Usa Health Mitchell Cancer Institute
  - Montgomery, Alabama, Forenede Stater, 36106
    - Montgomery Cancer Center
  - Tuscaloosa, Alabama, Forenede Stater, 35406
    - Alabama Cancer Care of Tuscaloosa
- Alaska
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Oncology and Hematology
- Arizona
  - Casa Grande, Arizona, Forenede Stater, 85122
    - Cancer and Blood Specialists of Arizona
  - Goodyear, Arizona, Forenede Stater, 85338
    - City of Hope Phoenix
  - Phoenix, Arizona, Forenede Stater, 85054
    - Mayo Clinic - Arizona
  - Scottsdale, Arizona, Forenede Stater, 85258
    - Honor Health
  - Tucson, Arizona, Forenede Stater, 85719
    - University of Arizona Cancer Center
- Arkansas
  - Fort Smith, Arkansas, Forenede Stater, 72903
    - Mercy Hospital Fort Smith
  - Hot Springs, Arkansas, Forenede Stater, 71913
    - Genesis Cancer and Blood Institute
  - Little Rock, Arkansas, Forenede Stater, 72205
    - CARTI Cancer Center
- California
  - Chula Vista, California, Forenede Stater, 91911
    - Care Oncology Center
  - Duarte, California, Forenede Stater, 91010
    - City of Hope Cancer Center (California)
  - Fountain Valley, California, Forenede Stater, 92708
    - Cancer and Blood Specialty Clinics
  - Fresno, California, Forenede Stater, 93720
    - California Cancer Associates for Research and Excellence
  - Fullerton, California, Forenede Stater, 92835
    - Providence St. Jude
  - Greenbrae, California, Forenede Stater, 94904
    - Marin Cancer Care
  - Los Angeles, California, Forenede Stater, 90048
    - Cedars-Sinai Medical Center
  - Los Angeles, California, Forenede Stater, 90095
    - University of California
  - Los Angeles, California, Forenede Stater, 90033
    - USC Norris Comprehensive Cancer Hospital
  - Los Angeles, California, Forenede Stater, 90095
    - UCLA Health Westlake Village
  - Monterey, California, Forenede Stater, 93940
    - Pacific Cancer Care
  - Mountain View, California, Forenede Stater, 94040
    - El Camino Health
  - Oakland, California, Forenede Stater, 94158
    - University of California - San Francisco
  - Orange, California, Forenede Stater, 92612
    - UCI Health
  - Palm Springs, California, Forenede Stater, 92262
    - Desert Care Network Comprehensive Cancer
  - Roseville, California, Forenede Stater, 95661
    - The Kaiser Permanente Medical Group
  - Sacramento, California, Forenede Stater, 95816
    - Sutter Health
  - San Diego, California, Forenede Stater, 92037
    - Scripps Clinic Torrey Pines
  - San Francisco, California, Forenede Stater, 94115
    - Sutter Health
  - San Francisco, California, Forenede Stater, 94143
    - Bakar Precision Cancer Medicine Building
  - San Luis Obispo, California, Forenede Stater, 93401
    - CommonSpirit
  - Santa Rosa, California, Forenede Stater, 95403
    - Providence Medical Foundation
  - Stanford, California, Forenede Stater, 94305
    - Stanford University
  - Vacaville, California, Forenede Stater, 95687
    - NorthBay Health Heidi Y Campini Cancer Center
  - Walnut Creek, California, Forenede Stater, 94598
    - UCSF John Muir Health
- Colorado
  - Aurora, Colorado, Forenede Stater, 80012
    - Rocky Mountain Cancer Center
  - Colorado Springs, Colorado, Forenede Stater, 80920
    - UC Health Memorial Health System
  - Denver, Colorado, Forenede Stater, 80210
    - AdventHealth Porter
  - Denver, Colorado, Forenede Stater, 80211
    - Intermountain Health
  - Durango, Colorado, Forenede Stater, 81301
    - CommonSpirit Oncology Mercy
  - Fort Collins, Colorado, Forenede Stater, 80528
    - UCHealth Poudre Valley Hospital
- Connecticut
  - New Haven, Connecticut, Forenede Stater, 06519
    - Yale New Haven Hospital
  - Norwalk, Connecticut, Forenede Stater, 06856
    - Norwalk Hospital
  - Norwich, Connecticut, Forenede Stater, 06360
    - Eastern Connecticut Hematology and Oncology
- Florida
  - Boca Raton, Florida, Forenede Stater, 33487
    - Lynn Cancer Institute - Boca Raton Regional Hospital
  - Brooksville, Florida, Forenede Stater, 36413
    - Advanced Cancer Treatment Centers
  - Hollywood, Florida, Forenede Stater, 33021
    - Memorial Cancer Institute
  - Jacksonville, Florida, Forenede Stater, 32224
    - Mayo Clinic - Florida
  - Jacksonville, Florida, Forenede Stater, 32256
    - Cancer Specialists of North Florida
  - Miami, Florida, Forenede Stater, 33176
    - Baptist Hospital of Miami
  - Miami, Florida, Forenede Stater, 33136
    - Sylvester Comprehensive Cancer Center
  - Miami Beach, Florida, Forenede Stater, 33140
    - Mount Sinai Medical Center of Florida
  - Naples, Florida, Forenede Stater, 32746
    - Florida Cancer Specialists and Research Institute
  - Orlando, Florida, Forenede Stater, 32803
    - Advent Health
  - Orlando, Florida, Forenede Stater, 33308
    - Holy Cross Health - Phil Smith Neuroscience Institute ALS Multidisciplinary Clinic
  - Pensacola, Florida, Forenede Stater, 32504
    - Ascension Sacred Heart
  - Sarasota, Florida, Forenede Stater, 34232
    - Intercoastal Medical Group
  - Tampa, Florida, Forenede Stater, 33606
    - Tampa General Hospital
  - Tampa, Florida, Forenede Stater, 33612
    - Moffitt Cancer Center
- Georgia
  - Atlanta, Georgia, Forenede Stater, 30322
    - Emory University Hospital
  - Atlanta, Georgia, Forenede Stater, 30318
    - Piedmont Cancer Institute - Atlanta
  - Atlanta, Georgia, Forenede Stater, 30318
    - Piedmont Physicians Medical Oncology
  - Atlanta, Georgia, Forenede Stater, 30342
    - North Side Hospital - Atlanta Cancer Care
  - Columbus, Georgia, Forenede Stater, 31904
    - Piedmont Columbus Regional Midtown
  - Macon, Georgia, Forenede Stater, 31210
    - Central Georgia Cancer Care
  - Marietta, Georgia, Forenede Stater, 30060
    - Northwest Georgia Oncology Centers
- Hawaii
  - Honolulu, Hawaii, Forenede Stater, 96813
    - The Queen's Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96814
    - Hawai'i Pacific Health
- Idaho
  - Boise, Idaho, Forenede Stater, 83712
    - St Luke's Cancer Institute
  - Post Falls, Idaho, Forenede Stater, 83854
    - Beacon Clinic
- Illinois
  - Arlington Heights, Illinois, Forenede Stater, 60005
    - Illinois Cancer Specialist
  - Chicago, Illinois, Forenede Stater, 60611
    - Northwestern University
  - Chicago, Illinois, Forenede Stater, 60637
    - University Of Chicago Medical Center
  - Downers Grove, Illinois, Forenede Stater, 60515
    - Advocate Health Care
  - Naperville, Illinois, Forenede Stater, 60126
    - Endeavor Health Cancer Institute
  - Peoria, Illinois, Forenede Stater, 61615
    - Illinois CancerCare
  - Peoria, Illinois, Forenede Stater, 61637
    - OSF Cancer Institute
  - Quincy, Illinois, Forenede Stater, 62301
    - Blessing Hospital
  - Rolling Meadows, Illinois, Forenede Stater, 60008
    - Northwest Oncology & Hematology
  - Zion, Illinois, Forenede Stater, 60099
    - City of Hope Chicago
- Indiana
  - Fort Wayne, Indiana, Forenede Stater, 46845
    - Parkview Packnett Family Cancer Institute
  - Indianapolis, Indiana, Forenede Stater, 46202
    - Indiana University School of Medicine
  - Indianapolis, Indiana, Forenede Stater, 46237
    - Franciscan Alliance Health
  - Newburgh, Indiana, Forenede Stater, 47630
    - Ascension Medical Group St. Vincent
  - Newburgh, Indiana, Forenede Stater, 47630
    - Deaconess Health System
- Iowa
  - Ames, Iowa, Forenede Stater, 50010
    - McFarland Clinic
  - Bettendorf, Iowa, Forenede Stater, 52722
    - University of Iowa Cancer Services Quad Cities
  - Cedar Rapids, Iowa, Forenede Stater, 52403
    - Mercy Medical Center
  - Waukee, Iowa, Forenede Stater, 50263
    - University of Iowa
- Kansas
  - Merriam, Kansas, Forenede Stater, 66204
    - Advent Health Shawnee Mission
  - Westwood, Kansas, Forenede Stater, 66205
    - University of Kansas Medical Center
  - Wichita, Kansas, Forenede Stater, 67214
    - Cancer Center of Kansas
- Kentucky
  - Edgewood, Kentucky, Forenede Stater, 41017
    - St. Elizabeth Healthcare
  - Lexington, Kentucky, Forenede Stater, 40503
    - Baptist Health Lexington
  - Louisville, Kentucky, Forenede Stater, 40217
    - Norton Cancer Institute
  - Owensboro, Kentucky, Forenede Stater, 42303
    - Owensboro Health Mitchell Memorial Cancer Center
  - Paducah, Kentucky, Forenede Stater, 42003
    - Mercy Health - Paducah Cancer Center
- Louisiana
  - New Orleans, Louisiana, Forenede Stater, 70121
    - Ochsner Health System
  - New Orleans, Louisiana, Forenede Stater, 70112
    - LSU LCMC Health Cancer Center
  - Shreveport, Louisiana, Forenede Stater, 71103
    - Willis Knighton Cancer Center
- Maine
  - Topsham, Maine, Forenede Stater, 04086
    - New England Cancer Specialists
- Maryland
  - Baltimore, Maryland, Forenede Stater, 21231
    - Johns Hopkins
  - Frederick, Maryland, Forenede Stater, 21701
    - Frederick Health
- Massachusetts
  - Boston, Massachusetts, Forenede Stater, 02215
    - Beth Israel Deaconess Medical Center
  - Boston, Massachusetts, Forenede Stater, 02114
    - Massachusetts General Hospital
  - Boston, Massachusetts, Forenede Stater, 02215
    - Dana Farber Cancer Institute
  - Burlington, Massachusetts, Forenede Stater, 01805
    - Lahey Clinic
  - Natick, Massachusetts, Forenede Stater, 01760
    - Mountain Health Clinic
  - Worcester, Massachusetts, Forenede Stater, 01655
    - UMass Memorial Medical Center
- Michigan
  - Ann Arbor, Michigan, Forenede Stater, 48109
    - University of Michigan
  - Detroit, Michigan, Forenede Stater, 48202
    - Henry Ford Health
  - Detroit, Michigan, Forenede Stater, 48201
    - Karmanos Cancer Institute (Barbara Ann Karmanos Cancer Hospital)
  - Grand Rapids, Michigan, Forenede Stater, 49546
    - The Cancer & Hematology Centers
  - Royal Oak, Michigan, Forenede Stater, 48073
    - Hematology Oncology Consultants
  - Saginaw, Michigan, Forenede Stater, 48604
    - Covenant HealthCare
  - Ypsilanti, Michigan, Forenede Stater, 48197
    - Trinity Health Hospital
- Minnesota
  - Duluth, Minnesota, Forenede Stater, 55805
    - Essentia Health
  - Edina, Minnesota, Forenede Stater, 55435
    - USOR: Minnesota Oncology Hematology, PA
  - Rochester, Minnesota, Forenede Stater, 55905
    - Mayo Clinic Minnesota
  - Saint Louis Park, Minnesota, Forenede Stater, 55426
    - HealthPartners Frauenshuh Cancer Center
  - Saint Louis Park, Minnesota, Forenede Stater, 55426
    - Health Partners Frauenshuh Cancer Center
  - Saint Louis Park, Minnesota, Forenede Stater, 55426
    - Park Nicollet Specialty Center
  - Saint Paul, Minnesota, Forenede Stater, 55101
    - Health Partners Oncology
- Mississippi
  - Jackson, Mississippi, Forenede Stater, 39202
    - Jackson Oncology Associates
- Missouri
  - Columbia, Missouri, Forenede Stater, 65212
    - University Hospital - MU Health Care
  - Joplin, Missouri, Forenede Stater, 64804
    - Mercy Hospital Joplin
  - Kansas City, Missouri, Forenede Stater, 64111
    - Saint Luke's Hospital of Kansas City
  - Kansas City, Missouri, Forenede Stater, 64132
    - Mid America Cancer Care
  - Springfield, Missouri, Forenede Stater, 65807
    - Mercy Hospital Springfield
  - Springfield, Missouri, Forenede Stater, 65807
    - Oncology Hematology Associates
  - St Louis, Missouri, Forenede Stater, 63141
    - Washington University School of Medicine
  - St Louis, Missouri, Forenede Stater, 63128
    - Mercy Hospital St. Louis-South
  - St Louis, Missouri, Forenede Stater, 63141
    - Pratt Cancer Center
- Montana
  - Kalispell, Montana, Forenede Stater, 59901
    - Logan Health
- Nebraska
  - Lincoln, Nebraska, Forenede Stater, 68506
    - NHO Revive Research Institute
  - Omaha, Nebraska, Forenede Stater, 68130
    - Nebraska Cancer Specialists
  - Omaha, Nebraska, Forenede Stater, 68114
    - University of Nebraska Medical Center
- New Hampshire
  - Lebanon, New Hampshire, Forenede Stater, 03756
    - Dartmouth Hitchcock Medical Center
- New Jersey
  - Camden, New Jersey, Forenede Stater, 08103
    - MD Anderson at Cooper
  - Florham Park, New Jersey, Forenede Stater, 07932
    - Summit Health
  - Marlton, New Jersey, Forenede Stater, 08053
    - Lindenberg Cancer & Hematology Center
  - Morristown, New Jersey, Forenede Stater, 07960
    - Overlook Medical Center - Medical Diagnostic Associates - Atlantic Medical Group
  - New Brunswick, New Jersey, Forenede Stater, 08903
    - Rutgers Cancer Institute
  - Toms River, New Jersey, Forenede Stater, 08755
    - Community Medical Center
- New York
  - Albany, New York, Forenede Stater, 12206
    - New York Oncology Hematology
  - Brooklyn, New York, Forenede Stater, 11206
    - Hirschfeld Oncology
  - Brooklyn, New York, Forenede Stater, 11215
    - Dosik Hematology and Oncology
  - Lake Success, New York, Forenede Stater, 11042
    - Northwell Health
  - Long Island City, New York, Forenede Stater, 11101
    - Memorial Sloan Kettering Cancer Center
  - New York, New York, Forenede Stater, 10016
    - NYU Langone Health
  - New York, New York, Forenede Stater, 10032
    - Columbia University Irving Medical Center
  - New York, New York, Forenede Stater, 10029
    - The Mount Sinai Hospital
  - New York, New York, Forenede Stater, 10022
    - Columbia University
  - New York, New York, Forenede Stater, 11967
    - New York Cancer and Blood Specialists
  - Rochester, New York, Forenede Stater, 14626
    - Rochester Regional Health
  - Stony Brook, New York, Forenede Stater, 11794
    - Stony Brook University Hospital
  - The Bronx, New York, Forenede Stater, 10461
    - Montefiore Medical Center
- North Carolina
  - Charlotte, North Carolina, Forenede Stater, 28204
    - Atrium Health
  - Durham, North Carolina, Forenede Stater, 27710
    - Duke Cancer Institute
  - Huntersville, North Carolina, Forenede Stater, 28078
    - Carolina Biooncology Institute
  - Winston-Salem, North Carolina, Forenede Stater, 27157
    - Wake Forest University Health Sciences
- North Dakota
  - Fargo, North Dakota, Forenede Stater, 58102
    - Sanford Roger Maris Cancer Center
- Ohio
  - Canfield, Ohio, Forenede Stater, 44406
    - Blood and Cancer Center
  - Canton, Ohio, Forenede Stater, 44170
    - Aultman Hospital
  - Cincinnati, Ohio, Forenede Stater, 45242
    - OHC (Oncology Hematology Care)
  - Cleveland, Ohio, Forenede Stater, 44106
    - University Hospitals Cleveland Medical Center
  - Cleveland, Ohio, Forenede Stater, 44106
    - UH Seidman Cancer Centre
  - Cleveland, Ohio, Forenede Stater, 95000
    - Cleveland Clinic Foundation
  - Columbus, Ohio, Forenede Stater, 43214
    - Ohio Health
  - Columbus, Ohio, Forenede Stater, 43221
    - The Ohio State University Wexner Medical Center
  - Columbus, Ohio, Forenede Stater, 43219
    - Zangmeister Cancer Center
  - Columbus, Ohio, Forenede Stater, 43214
    - OhioHealth Mansfield Hospital
  - Columbus, Ohio, Forenede Stater, 43214
    - Jasonway Cancer Center
  - Dayton, Ohio, Forenede Stater, 45459
    - Premier Health OH
  - Kettering, Ohio, Forenede Stater, 45429
    - Kettering Health Cancer Center
  - Middletown, Ohio, Forenede Stater, 45005
    - Premier Health OH
- Oklahoma
  - Oklahoma City, Oklahoma, Forenede Stater, 73120
    - Mercy Hospital Oklahoma City
  - Oklahoma City, Oklahoma, Forenede Stater, 73104
    - OU Health Science Center - Stephenson Cancer Center
- Oregon
  - Corvallis, Oregon, Forenede Stater, 97330
    - Samaritan Hemotology and Oncology
  - Happy Valley, Oregon, Forenede Stater, 97223
    - Compass Oncology
  - Portland, Oregon, Forenede Stater, 97213
    - Providence Medical Center
  - Salem, Oregon, Forenede Stater, 97301
    - Oregon Oncology Specialists
  - Springfield, Oregon, Forenede Stater, 97477
    - Willamette Valley Cancer Institute
- Pennsylvania
  - Allentown, Pennsylvania, Forenede Stater, 18103
    - LeHigh Valley Hospital
  - Bethlehem, Pennsylvania, Forenede Stater, 18015
    - St. Luke's University Health Network
  - Bryn Mawr, Pennsylvania, Forenede Stater, 19010
    - Bryn Mawr Hospital
  - Butler, Pennsylvania, Forenede Stater, 15212
    - Allegheny Health Network Cancer Institute
  - Dunmore, Pennsylvania, Forenede Stater, 18512
    - Hematology & Oncology Associates of NEPA
  - Media, Pennsylvania, Forenede Stater, 19063
    - Alliance Cancer Specialists
  - Natrona Heights, Pennsylvania, Forenede Stater, 15212
    - Allegheny Valley Hospital
  - Paoli, Pennsylvania, Forenede Stater, 19301
    - Paoli Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19111
    - Fox Chase Cancer Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19104
    - University of Pennsylvania
  - Philadelphia, Pennsylvania, Forenede Stater, 19107
    - Thomas Jefferson University Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15224
    - University of Pittsburgh Medical Center (UPMC)
  - Pittsburgh, Pennsylvania, Forenede Stater, 15224
    - UPMC Western Maryland
  - Sayre, Pennsylvania, Forenede Stater, 18840
    - Guthrie Sayre
  - West Mifflin, Pennsylvania, Forenede Stater, 15122
    - UPMC Hillman Cancer Center
  - Wynnewood, Pennsylvania, Forenede Stater, 19096
    - Lankenau Medical Center
- Rhode Island
  - Providence, Rhode Island, Forenede Stater, 02903
    - Rhode Island Hospital
- South Carolina
  - Charleston, South Carolina, Forenede Stater, 29414
    - Bon Secours St. Francis Cancer Center
  - Florence, South Carolina, Forenede Stater, 29506
    - McLeod Health
  - Greer, South Carolina, Forenede Stater, 29651
    - Spartanburg Regional Healthcare System - Gibbs Cancer Center & Research Institute
- South Dakota
  - Rapid City, South Dakota, Forenede Stater, 57701
    - Monument Health Cancer Care Institute
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Avera Cancer Institute
  - Sioux Falls, South Dakota, Forenede Stater, 57104
    - Sanford Health
- Tennessee
  - Germantown, Tennessee, Forenede Stater, 38138
    - West Cancer Center
  - Knoxville, Tennessee, Forenede Stater, 37919
    - Tennessee Cancer Specialists
  - Memphis, Tennessee, Forenede Stater, 38120
    - Baptist Cancer Center
  - Nashville, Tennessee, Forenede Stater, 37203
    - Tennessee Oncology
  - Nashville, Tennessee, Forenede Stater, 37203
    - Sarah Cannon Cancer Institute
- Texas
  - Dallas, Texas, Forenede Stater, 75390
    - University of Texas Southwestern Medical
  - Edinburg, Texas, Forenede Stater, 78539
    - DHR Health
  - Fort Bliss, Texas, Forenede Stater, 79918
    - William Beaumont Army Medical Center - Fort Bliss
  - Houston, Texas, Forenede Stater, 77030
    - MD Anderson Cancer Center
  - Houston, Texas, Forenede Stater, 77024
    - American Oncology Network - Oncology Consultants
  - Houston, Texas, Forenede Stater, 77030
    - Houston Methodist Hospital- Cancer Center
  - Lubbock, Texas, Forenede Stater, 79410
    - Covenant Health - Joe Arrington Cancer Research and Treatment Center
  - Pearland, Texas, Forenede Stater, 77584
    - Texas Oncology
  - Richardson, Texas, Forenede Stater, 75082
    - Methodist Richardson Cancer Center
  - San Antonio, Texas, Forenede Stater, 78229
    - UT Health San Antonio MD Anderson Cancer Center
  - Temple, Texas, Forenede Stater, 76508
    - Baylor Scott & White Health
- Utah
  - Ogden, Utah, Forenede Stater, 84405
    - Ogden Clinic
  - Salt Lake City, Utah, Forenede Stater, 84106
    - Utah Cancer Specialists (UCS)
  - Salt Lake City, Utah, Forenede Stater, 84112
    - Huntsman Cancer Institute & Hospital
- Vermont
  - Burlington, Vermont, Forenede Stater, 05401
    - University of Vermont Medical Center
- Virginia
  - Fairfax, Virginia, Forenede Stater, 22031
    - Virginia Cancer Specialists
  - Fairfax, Virginia, Forenede Stater, 22031
    - Inova Schar Cancer
  - Fredericksburg, Virginia, Forenede Stater, 22408
    - Hematology Oncology Associates of Fredericksburg
  - Hampton, Virginia, Forenede Stater, 23606
    - Virginia Oncology Associates
  - Newport News, Virginia, Forenede Stater, 23320
    - Riverside Health
  - Richmond, Virginia, Forenede Stater, 23229
    - Virginia Cancer Institute
  - Richmond, Virginia, Forenede Stater, 23219
    - VCU Health
- Washington
  - Kennewick, Washington, Forenede Stater, 99336
    - Kadlec Regional Medical Center
  - Renton, Washington, Forenede Stater, 98057
    - Seattle Integrative Cancer Center
  - Seattle, Washington, Forenede Stater, 98101
    - Virginia Mason Medical Center
  - Seattle, Washington, Forenede Stater, 98109
    - Fred Hutch Cancer Center
  - Seattle, Washington, Forenede Stater, 98104
    - Providence Swedish Cancer Institute
  - Seattle, Washington, Forenede Stater, 98104
    - Swedish Cancer Institute Treatment Center
  - Walla Walla, Washington, Forenede Stater, 99362
    - Providence St. Mary Medical Center
- Wisconsin
  - Appleton, Wisconsin, Forenede Stater, 54611
    - ThedaCare Regional Cancer Center
  - Grafton, Wisconsin, Forenede Stater, 53024
    - Aurora Medical Center
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - HSHS St. Mary's Hospital Medical Center
  - Green Bay, Wisconsin, Forenede Stater, 54313
    - Bellin Health
  - La Crosse, Wisconsin, Forenede Stater, 05461
    - Emplify Health by Gundersen
  - Madison, Wisconsin, Forenede Stater, 53792
    - University of Wisconsin
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Medical Center
  - Milwaukee, Wisconsin, Forenede Stater, 53226
    - Medical College of Wisconsin
  - Waukesha, Wisconsin, Forenede Stater, 53072
    - UW Health Cancer Center at ProHealth Care
Puerto Rico
- - San Juan, Puerto Rico, 00909
    - PanOncology Centre

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

Voksen
Ældre voksen

Tager imod sunde frivillige

N/A

Beskrivelse

Inklusionskriterier:<\/p>

Mindst 18 år gammel og har givet informeret samtykke.<\/li>
Eastern Cooperative Oncology Group (ECOG) præstationsstatus på 0 eller 1.<\/li>
Histologisk eller cytologisk bekræftet PDAC med metastatisk sygdom.<\/li>
Bevis for aktiv sygdomsprogression under eller efter den seneste systemiske behandlingslinje for PDAC, baseret på investigatorvurdering.<\/li>
Mindst én tidligere systemisk behandlingslinje i metastatisk setting, som skal omfatte enten et fluoropyrimidin- eller gemcitabin-baseret regime.<\/li>
Har modtaget og progredieret, været intolerant over for tidligere standardbehandling, eller ikke længere forventes at have gavn af standardbehandlinger.<\/li>
Tilstrækkelig knoglemarvs-, nyre-, lever- og koagulationsfunktion.<\/li>
Ikke berettiget til, eller ude af stand til at deltage i, et andet klinisk forsøg med daraxonrasib, hvis tilgængeligt.<\/li>
I stand til at tage oral medicin.<\/li><\/ul>
Eksklusionskriterier:<\/p>
- Kendt historie med metastatisk sygdom i centralnervesystemet.<\/li>
- Samtidig systemisk kræftbehandling.<\/li>
- Betydelig kardiovaskulær sygdom.<\/li>
- Større GI-tilstande, der kan påvirke evnen til at tage eller absorbere daraxonrasib (patienter med tidligere Whipple-operation er kvalificerede).<\/li>
- Aktiv ukontrolleret systemisk infektion.<\/li>
- Større operation inden for 28 dage før inklusion.<\/li>
- Yderligere inklusions- og eksklusionskriterier kan gælde.<\/li><\/ul>

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Revolution Medicines, Inc.

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Hjælpsomme links

Related Info

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Datoer for studieregistrering

Først indsendt

1. maj 2026

Først indsendt, der opfyldte QC-kriterier

1. maj 2026

Først opslået (Faktiske)

7. maj 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

1. september 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

27. august 2026

Sidst verificeret

1. juli 2026

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

RMC-6236-401

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .