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Utvidet tilgangsprogram for Daraxonrasib (RMC-6236) ved tidligere behandlet metastatisk pankreatisk adenokarsinom

27. august 2026 oppdatert av: Revolution Medicines, Inc.

Utvidet tilgangsprogram for å behandle pasienter med tidligere behandlet metastatisk pankreasadenokarsinom med Daraxonrasib

This Expanded Access Program (EAP) is intended to provide daraxonrasib to eligible adult patients with previously treated metastatic pancreatic adenocarcinoma, who have no comparable or satisfactory alternative therapy and are unable to participate in an ongoing daraxonrasib clinical trial.

Studieoversikt

Status

Godkjent for markedsføring

Forhold

Intervensjon / Behandling

Legemiddel: daraxonrasib

Detaljert beskrivelse

This EAP has been established to provide access to daraxonrasib to patients with previously treated metastatic pancreatic adenocarcinoma during the period before potential commercial availability. Patients may be eligible if they have progressed on, are intolerant of, or are no longer expected to benefit from available standard therapies, and if they are not able to enroll in a clinical trial of daraxonrasib due to ineligibility or lack of access. This EAP is intended to address an unmet medical need and is not designed to support clinical development objectives.

Daraxonrasib is an investigational, orally administered, RAS(ON) inhibitor administered as monotherapy. Daraxonrasib will be supplied by the Sponsor free of charge during the duration of treatment under this program.

Studietype

Utvidet tilgang

Utvidet tilgangstype

Behandling IND/Protokoll

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiesteder

Forente stater
- Alabama
  - Birmingham, Alabama, Forente stater, 35243
    - Alabama Oncology
  - Daphne, Alabama, Forente stater, 36526
    - Southern Cancer Center
  - Dothan, Alabama, Forente stater, 36303
    - Dothan Hematology and Oncology
  - Fort Payne, Alabama, Forente stater, 35967
    - Alabama Cancer Care of Ft Payne
  - Mobile, Alabama, Forente stater, 36608
    - Southern Cancer Center
  - Mobile, Alabama, Forente stater, 36604
    - USA Health Mitchell Cancer Institute
  - Montgomery, Alabama, Forente stater, 36106
    - Montgomery Cancer Center
  - Tuscaloosa, Alabama, Forente stater, 35406
    - Alabama Cancer Care of Tuscaloosa
- Alaska
  - Anchorage, Alaska, Forente stater, 99508
    - Alaska Oncology and Hematology
- Arizona
  - Casa Grande, Arizona, Forente stater, 85122
    - Cancer and Blood Specialists of Arizona
  - Goodyear, Arizona, Forente stater, 85338
    - City of Hope Phoenix
  - Phoenix, Arizona, Forente stater, 85054
    - Mayo Clinic - Arizona
  - Scottsdale, Arizona, Forente stater, 85258
    - Honor Health
  - Tucson, Arizona, Forente stater, 85719
    - University of Arizona Cancer Center
- Arkansas
  - Fort Smith, Arkansas, Forente stater, 72903
    - Mercy Hospital Fort Smith
  - Hot Springs, Arkansas, Forente stater, 71913
    - Genesis Cancer and Blood Institute
  - Little Rock, Arkansas, Forente stater, 72205
    - Carti Cancer Center
- California
  - Chula Vista, California, Forente stater, 91911
    - Care Oncology Center
  - Duarte, California, Forente stater, 91010
    - City of Hope Cancer Center (California)
  - Fountain Valley, California, Forente stater, 92708
    - Cancer and Blood Specialty Clinics
  - Fresno, California, Forente stater, 93720
    - California Cancer Associates for Research and Excellence
  - Fullerton, California, Forente stater, 92835
    - Providence St. Jude
  - Greenbrae, California, Forente stater, 94904
    - Marin Cancer Care
  - Los Angeles, California, Forente stater, 90048
    - Cedars-Sinai Medical Center
  - Los Angeles, California, Forente stater, 90095
    - University of California
  - Los Angeles, California, Forente stater, 90033
    - USC Norris Comprehensive Cancer Hospital
  - Los Angeles, California, Forente stater, 90095
    - UCLA Health Westlake Village
  - Monterey, California, Forente stater, 93940
    - Pacific Cancer Care
  - Mountain View, California, Forente stater, 94040
    - El Camino Health
  - Oakland, California, Forente stater, 94158
    - University of California - San Francisco
  - Orange, California, Forente stater, 92612
    - UCI Health
  - Palm Springs, California, Forente stater, 92262
    - Desert Care Network Comprehensive Cancer
  - Roseville, California, Forente stater, 95661
    - The Kaiser Permanente Medical Group
  - Sacramento, California, Forente stater, 95816
    - Sutter Health
  - San Diego, California, Forente stater, 92037
    - Scripps Clinic Torrey Pines
  - San Francisco, California, Forente stater, 94115
    - Sutter Health
  - San Francisco, California, Forente stater, 94143
    - Bakar Precision Cancer Medicine Building
  - San Luis Obispo, California, Forente stater, 93401
    - CommonSpirit
  - Santa Rosa, California, Forente stater, 95403
    - Providence Medical Foundation
  - Stanford, California, Forente stater, 94305
    - Stanford University
  - Vacaville, California, Forente stater, 95687
    - NorthBay Health Heidi Y Campini Cancer Center
  - Walnut Creek, California, Forente stater, 94598
    - UCSF John Muir Health
- Colorado
  - Aurora, Colorado, Forente stater, 80012
    - Rocky Mountain Cancer Center
  - Colorado Springs, Colorado, Forente stater, 80920
    - UC Health Memorial Health System
  - Denver, Colorado, Forente stater, 80210
    - AdventHealth Porter
  - Denver, Colorado, Forente stater, 80211
    - Intermountain Health
  - Durango, Colorado, Forente stater, 81301
    - CommonSpirit Oncology Mercy
  - Fort Collins, Colorado, Forente stater, 80528
    - UCHealth Poudre Valley Hospital
- Connecticut
  - New Haven, Connecticut, Forente stater, 06519
    - Yale New Haven Hospital
  - Norwalk, Connecticut, Forente stater, 06856
    - Norwalk Hospital
  - Norwich, Connecticut, Forente stater, 06360
    - Eastern Connecticut Hematology and Oncology
- Florida
  - Boca Raton, Florida, Forente stater, 33487
    - Lynn Cancer Institute - Boca Raton Regional Hospital
  - Brooksville, Florida, Forente stater, 36413
    - Advanced Cancer Treatment Centers
  - Hollywood, Florida, Forente stater, 33021
    - Memorial Cancer Institute
  - Jacksonville, Florida, Forente stater, 32224
    - Mayo Clinic - Florida
  - Jacksonville, Florida, Forente stater, 32256
    - Cancer Specialists of North Florida
  - Miami, Florida, Forente stater, 33176
    - Baptist Hospital of Miami
  - Miami, Florida, Forente stater, 33136
    - Sylvester Comprehensive Cancer Center
  - Miami Beach, Florida, Forente stater, 33140
    - Mount Sinai Medical Center of Florida
  - Naples, Florida, Forente stater, 32746
    - Florida Cancer Specialists and Research Institute
  - Orlando, Florida, Forente stater, 32803
    - Advent Health
  - Orlando, Florida, Forente stater, 33308
    - Holy Cross Health - Phil Smith Neuroscience Institute ALS Multidisciplinary Clinic
  - Pensacola, Florida, Forente stater, 32504
    - Ascension Sacred Heart
  - Sarasota, Florida, Forente stater, 34232
    - Intercoastal Medical Group
  - Tampa, Florida, Forente stater, 33606
    - Tampa General Hospital
  - Tampa, Florida, Forente stater, 33612
    - Moffitt Cancer Center
- Georgia
  - Atlanta, Georgia, Forente stater, 30322
    - Emory University Hospital
  - Atlanta, Georgia, Forente stater, 30318
    - Piedmont Cancer Institute - Atlanta
  - Atlanta, Georgia, Forente stater, 30318
    - Piedmont Physicians Medical Oncology
  - Atlanta, Georgia, Forente stater, 30342
    - North Side Hospital - Atlanta Cancer Care
  - Columbus, Georgia, Forente stater, 31904
    - Piedmont Columbus Regional Midtown
  - Macon, Georgia, Forente stater, 31210
    - Central Georgia Cancer Care
  - Marietta, Georgia, Forente stater, 30060
    - Northwest Georgia Oncology Centers
- Hawaii
  - Honolulu, Hawaii, Forente stater, 96813
    - The Queen's Medical Center
  - Honolulu, Hawaii, Forente stater, 96814
    - Hawai'i Pacific Health
- Idaho
  - Boise, Idaho, Forente stater, 83712
    - St Luke's Cancer Institute
  - Post Falls, Idaho, Forente stater, 83854
    - Beacon Clinic
- Illinois
  - Arlington Heights, Illinois, Forente stater, 60005
    - Illinois Cancer Specialist
  - Chicago, Illinois, Forente stater, 60611
    - Northwestern University
  - Chicago, Illinois, Forente stater, 60637
    - University of Chicago Medical Center
  - Downers Grove, Illinois, Forente stater, 60515
    - Advocate Health Care
  - Naperville, Illinois, Forente stater, 60126
    - Endeavor Health Cancer Institute
  - Peoria, Illinois, Forente stater, 61615
    - Illinois CancerCare
  - Peoria, Illinois, Forente stater, 61637
    - OSF Cancer Institute
  - Quincy, Illinois, Forente stater, 62301
    - Blessing Hospital
  - Rolling Meadows, Illinois, Forente stater, 60008
    - Northwest Oncology & Hematology
  - Zion, Illinois, Forente stater, 60099
    - City of Hope Chicago
- Indiana
  - Fort Wayne, Indiana, Forente stater, 46845
    - Parkview Packnett Family Cancer Institute
  - Indianapolis, Indiana, Forente stater, 46202
    - Indiana University School of Medicine
  - Indianapolis, Indiana, Forente stater, 46237
    - Franciscan Alliance Health
  - Newburgh, Indiana, Forente stater, 47630
    - Ascension Medical Group St. Vincent
  - Newburgh, Indiana, Forente stater, 47630
    - Deaconess Health System
- Iowa
  - Ames, Iowa, Forente stater, 50010
    - McFarland Clinic
  - Bettendorf, Iowa, Forente stater, 52722
    - University of Iowa Cancer Services Quad Cities
  - Cedar Rapids, Iowa, Forente stater, 52403
    - Mercy Medical Center
  - Waukee, Iowa, Forente stater, 50263
    - University of Iowa
- Kansas
  - Merriam, Kansas, Forente stater, 66204
    - Advent Health Shawnee Mission
  - Westwood, Kansas, Forente stater, 66205
    - University of Kansas Medical Center
  - Wichita, Kansas, Forente stater, 67214
    - Cancer Center of Kansas
- Kentucky
  - Edgewood, Kentucky, Forente stater, 41017
    - St. Elizabeth Healthcare
  - Lexington, Kentucky, Forente stater, 40503
    - Baptist Health Lexington
  - Louisville, Kentucky, Forente stater, 40217
    - Norton Cancer Institute
  - Owensboro, Kentucky, Forente stater, 42303
    - Owensboro Health Mitchell Memorial Cancer Center
  - Paducah, Kentucky, Forente stater, 42003
    - Mercy Health - Paducah Cancer Center
- Louisiana
  - New Orleans, Louisiana, Forente stater, 70121
    - Ochsner Health System
  - New Orleans, Louisiana, Forente stater, 70112
    - LSU LCMC Health Cancer Center
  - Shreveport, Louisiana, Forente stater, 71103
    - Willis Knighton Cancer Center
- Maine
  - Topsham, Maine, Forente stater, 04086
    - New England Cancer Specialists
- Maryland
  - Baltimore, Maryland, Forente stater, 21231
    - Johns Hopkins
  - Frederick, Maryland, Forente stater, 21701
    - Frederick Health
- Massachusetts
  - Boston, Massachusetts, Forente stater, 02215
    - Beth Israel Deaconess Medical Center
  - Boston, Massachusetts, Forente stater, 02114
    - Massachusetts General Hospital
  - Boston, Massachusetts, Forente stater, 02215
    - Dana Farber Cancer Institute
  - Burlington, Massachusetts, Forente stater, 01805
    - Lahey Clinic
  - Natick, Massachusetts, Forente stater, 01760
    - Mountain Health Clinic
  - Worcester, Massachusetts, Forente stater, 01655
    - UMass Memorial Medical Center
- Michigan
  - Ann Arbor, Michigan, Forente stater, 48109
    - University of Michigan
  - Detroit, Michigan, Forente stater, 48202
    - Henry Ford Health
  - Detroit, Michigan, Forente stater, 48201
    - Karmanos Cancer Institute (Barbara Ann Karmanos Cancer Hospital)
  - Grand Rapids, Michigan, Forente stater, 49546
    - The Cancer & Hematology Centers
  - Royal Oak, Michigan, Forente stater, 48073
    - Hematology Oncology Consultants
  - Saginaw, Michigan, Forente stater, 48604
    - Covenant HealthCare
  - Ypsilanti, Michigan, Forente stater, 48197
    - Trinity Health Hospital
- Minnesota
  - Duluth, Minnesota, Forente stater, 55805
    - Essentia Health
  - Edina, Minnesota, Forente stater, 55435
    - USOR: Minnesota Oncology Hematology, PA
  - Rochester, Minnesota, Forente stater, 55905
    - Mayo Clinic Minnesota
  - Saint Louis Park, Minnesota, Forente stater, 55426
    - HealthPartners Frauenshuh Cancer Center
  - Saint Louis Park, Minnesota, Forente stater, 55426
    - Health Partners Frauenshuh Cancer Center
  - Saint Louis Park, Minnesota, Forente stater, 55426
    - Park Nicollet Specialty Center
  - Saint Paul, Minnesota, Forente stater, 55101
    - Health Partners Oncology
- Mississippi
  - Jackson, Mississippi, Forente stater, 39202
    - Jackson Oncology Associates
- Missouri
  - Columbia, Missouri, Forente stater, 65212
    - University Hospital - MU Health Care
  - Joplin, Missouri, Forente stater, 64804
    - Mercy Hospital Joplin
  - Kansas City, Missouri, Forente stater, 64111
    - Saint Luke's Hospital of Kansas City
  - Kansas City, Missouri, Forente stater, 64132
    - Mid America Cancer Care
  - Springfield, Missouri, Forente stater, 65807
    - Mercy Hospital Springfield
  - Springfield, Missouri, Forente stater, 65807
    - Oncology Hematology Associates
  - St Louis, Missouri, Forente stater, 63141
    - Washington University School of Medicine
  - St Louis, Missouri, Forente stater, 63128
    - Mercy Hospital St. Louis-South
  - St Louis, Missouri, Forente stater, 63141
    - Pratt Cancer Center
- Montana
  - Kalispell, Montana, Forente stater, 59901
    - Logan Health
- Nebraska
  - Lincoln, Nebraska, Forente stater, 68506
    - NHO Revive Research Institute
  - Omaha, Nebraska, Forente stater, 68130
    - Nebraska Cancer Specialists
  - Omaha, Nebraska, Forente stater, 68114
    - University of Nebraska Medical Center
- New Hampshire
  - Lebanon, New Hampshire, Forente stater, 03756
    - Dartmouth Hitchcock Medical Center
- New Jersey
  - Camden, New Jersey, Forente stater, 08103
    - MD Anderson at Cooper
  - Florham Park, New Jersey, Forente stater, 07932
    - Summit Health
  - Marlton, New Jersey, Forente stater, 08053
    - Lindenberg Cancer & Hematology Center
  - Morristown, New Jersey, Forente stater, 07960
    - Overlook Medical Center - Medical Diagnostic Associates - Atlantic Medical Group
  - New Brunswick, New Jersey, Forente stater, 08903
    - Rutgers Cancer Institute
  - Toms River, New Jersey, Forente stater, 08755
    - Community Medical Center
- New York
  - Albany, New York, Forente stater, 12206
    - New York Oncology Hematology
  - Brooklyn, New York, Forente stater, 11206
    - Hirschfeld Oncology
  - Brooklyn, New York, Forente stater, 11215
    - Dosik Hematology and Oncology
  - Lake Success, New York, Forente stater, 11042
    - Northwell Health
  - Long Island City, New York, Forente stater, 11101
    - Memorial Sloan Kettering Cancer Center
  - New York, New York, Forente stater, 10016
    - NYU Langone Health
  - New York, New York, Forente stater, 10032
    - Columbia University Irving Medical Center
  - New York, New York, Forente stater, 10029
    - The Mount Sinai Hospital
  - New York, New York, Forente stater, 10022
    - Columbia University
  - New York, New York, Forente stater, 11967
    - New York Cancer and Blood Specialists
  - Rochester, New York, Forente stater, 14626
    - Rochester Regional Health
  - Stony Brook, New York, Forente stater, 11794
    - Stony Brook University Hospital
  - The Bronx, New York, Forente stater, 10461
    - Montefiore Medical Center
- North Carolina
  - Charlotte, North Carolina, Forente stater, 28204
    - Atrium Health
  - Durham, North Carolina, Forente stater, 27710
    - Duke Cancer Institute
  - Huntersville, North Carolina, Forente stater, 28078
    - Carolina BioOncology Institute
  - Winston-Salem, North Carolina, Forente stater, 27157
    - Wake Forest University Health Sciences
- North Dakota
  - Fargo, North Dakota, Forente stater, 58102
    - Sanford Roger Maris Cancer Center
- Ohio
  - Canfield, Ohio, Forente stater, 44406
    - Blood and Cancer Center
  - Canton, Ohio, Forente stater, 44170
    - Aultman Hospital
  - Cincinnati, Ohio, Forente stater, 45242
    - OHC (Oncology Hematology Care)
  - Cleveland, Ohio, Forente stater, 44106
    - University Hospitals Cleveland Medical Center
  - Cleveland, Ohio, Forente stater, 44106
    - UH Seidman Cancer Centre
  - Cleveland, Ohio, Forente stater, 95000
    - Cleveland Clinic Foundation
  - Columbus, Ohio, Forente stater, 43214
    - Ohio Health
  - Columbus, Ohio, Forente stater, 43221
    - The Ohio State University Wexner Medical Center
  - Columbus, Ohio, Forente stater, 43219
    - Zangmeister Cancer Center
  - Columbus, Ohio, Forente stater, 43214
    - OhioHealth Mansfield Hospital
  - Columbus, Ohio, Forente stater, 43214
    - Jasonway Cancer Center
  - Dayton, Ohio, Forente stater, 45459
    - Premier Health OH
  - Kettering, Ohio, Forente stater, 45429
    - Kettering Health Cancer Center
  - Middletown, Ohio, Forente stater, 45005
    - Premier Health OH
- Oklahoma
  - Oklahoma City, Oklahoma, Forente stater, 73120
    - Mercy Hospital Oklahoma City
  - Oklahoma City, Oklahoma, Forente stater, 73104
    - OU Health Science Center - Stephenson Cancer Center
- Oregon
  - Corvallis, Oregon, Forente stater, 97330
    - Samaritan Hemotology and Oncology
  - Happy Valley, Oregon, Forente stater, 97223
    - Compass Oncology
  - Portland, Oregon, Forente stater, 97213
    - Providence Medical Center
  - Salem, Oregon, Forente stater, 97301
    - Oregon Oncology Specialists
  - Springfield, Oregon, Forente stater, 97477
    - Willamette Valley Cancer Institute
- Pennsylvania
  - Allentown, Pennsylvania, Forente stater, 18103
    - Lehigh Valley Hospital
  - Bethlehem, Pennsylvania, Forente stater, 18015
    - St. Luke's University Health Network
  - Bryn Mawr, Pennsylvania, Forente stater, 19010
    - Bryn Mawr Hospital
  - Butler, Pennsylvania, Forente stater, 15212
    - Allegheny Health Network Cancer Institute
  - Dunmore, Pennsylvania, Forente stater, 18512
    - Hematology & Oncology Associates of NEPA
  - Media, Pennsylvania, Forente stater, 19063
    - Alliance Cancer Specialists
  - Natrona Heights, Pennsylvania, Forente stater, 15212
    - Allegheny Valley Hospital
  - Paoli, Pennsylvania, Forente stater, 19301
    - Paoli Hospital
  - Philadelphia, Pennsylvania, Forente stater, 19111
    - Fox Chase Cancer Center
  - Philadelphia, Pennsylvania, Forente stater, 19104
    - University of Pennsylvania
  - Philadelphia, Pennsylvania, Forente stater, 19107
    - Thomas Jefferson University Hospital
  - Pittsburgh, Pennsylvania, Forente stater, 15224
    - University of Pittsburgh Medical Center (UPMC)
  - Pittsburgh, Pennsylvania, Forente stater, 15224
    - UPMC Western Maryland
  - Sayre, Pennsylvania, Forente stater, 18840
    - Guthrie Sayre
  - West Mifflin, Pennsylvania, Forente stater, 15122
    - UPMC Hillman Cancer Center
  - Wynnewood, Pennsylvania, Forente stater, 19096
    - Lankenau Medical Center
- Rhode Island
  - Providence, Rhode Island, Forente stater, 02903
    - Rhode Island Hospital
- South Carolina
  - Charleston, South Carolina, Forente stater, 29414
    - Bon Secours St. Francis Cancer Center
  - Florence, South Carolina, Forente stater, 29506
    - McLeod Health
  - Greer, South Carolina, Forente stater, 29651
    - Spartanburg Regional Healthcare System - Gibbs Cancer Center & Research Institute
- South Dakota
  - Rapid City, South Dakota, Forente stater, 57701
    - Monument Health Cancer Care Institute
  - Sioux Falls, South Dakota, Forente stater, 57105
    - Avera Cancer Institute
  - Sioux Falls, South Dakota, Forente stater, 57104
    - Sanford Health
- Tennessee
  - Germantown, Tennessee, Forente stater, 38138
    - West Cancer Center
  - Knoxville, Tennessee, Forente stater, 37919
    - Tennessee Cancer Specialists
  - Memphis, Tennessee, Forente stater, 38120
    - Baptist Cancer Center
  - Nashville, Tennessee, Forente stater, 37203
    - Tennessee Oncology
  - Nashville, Tennessee, Forente stater, 37203
    - Sarah Cannon Cancer Institute
- Texas
  - Dallas, Texas, Forente stater, 75390
    - University of Texas Southwestern Medical
  - Edinburg, Texas, Forente stater, 78539
    - DHR Health
  - Fort Bliss, Texas, Forente stater, 79918
    - William Beaumont Army Medical Center - Fort Bliss
  - Houston, Texas, Forente stater, 77030
    - MD Anderson Cancer Center
  - Houston, Texas, Forente stater, 77024
    - American Oncology Network - Oncology Consultants
  - Houston, Texas, Forente stater, 77030
    - Houston Methodist Hospital- Cancer Center
  - Lubbock, Texas, Forente stater, 79410
    - Covenant Health - Joe Arrington Cancer Research and Treatment Center
  - Pearland, Texas, Forente stater, 77584
    - Texas Oncology
  - Richardson, Texas, Forente stater, 75082
    - Methodist Richardson Cancer Center
  - San Antonio, Texas, Forente stater, 78229
    - UT Health San Antonio MD Anderson Cancer Center
  - Temple, Texas, Forente stater, 76508
    - Baylor Scott & White Health
- Utah
  - Ogden, Utah, Forente stater, 84405
    - Ogden Clinic
  - Salt Lake City, Utah, Forente stater, 84106
    - Utah Cancer Specialists (UCS)
  - Salt Lake City, Utah, Forente stater, 84112
    - Huntsman Cancer Institute & Hospital
- Vermont
  - Burlington, Vermont, Forente stater, 05401
    - University of Vermont Medical Center
- Virginia
  - Fairfax, Virginia, Forente stater, 22031
    - Virginia Cancer Specialists
  - Fairfax, Virginia, Forente stater, 22031
    - Inova Schar Cancer
  - Fredericksburg, Virginia, Forente stater, 22408
    - Hematology Oncology Associates of Fredericksburg
  - Hampton, Virginia, Forente stater, 23606
    - Virginia Oncology Associates
  - Newport News, Virginia, Forente stater, 23320
    - Riverside Health
  - Richmond, Virginia, Forente stater, 23229
    - Virginia Cancer Institute
  - Richmond, Virginia, Forente stater, 23219
    - VCU Health
- Washington
  - Kennewick, Washington, Forente stater, 99336
    - Kadlec Regional Medical Center
  - Renton, Washington, Forente stater, 98057
    - Seattle Integrative Cancer Center
  - Seattle, Washington, Forente stater, 98101
    - Virginia Mason Medical Center
  - Seattle, Washington, Forente stater, 98109
    - Fred Hutch Cancer Center
  - Seattle, Washington, Forente stater, 98104
    - Providence Swedish Cancer Institute
  - Seattle, Washington, Forente stater, 98104
    - Swedish Cancer Institute Treatment Center
  - Walla Walla, Washington, Forente stater, 99362
    - Providence St. Mary Medical Center
- Wisconsin
  - Appleton, Wisconsin, Forente stater, 54611
    - ThedaCare Regional Cancer Center
  - Grafton, Wisconsin, Forente stater, 53024
    - Aurora Medical Center
  - Green Bay, Wisconsin, Forente stater, 54303
    - HSHS St. Mary's Hospital Medical Center
  - Green Bay, Wisconsin, Forente stater, 54313
    - Bellin Health
  - La Crosse, Wisconsin, Forente stater, 05461
    - Emplify Health by Gundersen
  - Madison, Wisconsin, Forente stater, 53792
    - University of Wisconsin
  - Marshfield, Wisconsin, Forente stater, 54449
    - Marshfield Medical Center
  - Milwaukee, Wisconsin, Forente stater, 53226
    - Medical College of Wisconsin
  - Waukesha, Wisconsin, Forente stater, 53072
    - UW Health Cancer Center at ProHealth Care
Puerto Rico
- - San Juan, Puerto Rico, 00909
    - PanOncology Centre

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

18 år og eldre (Voksen, Eldre voksen)

Tar imot friske frivillige

N/A

Kjønn som er kvalifisert for studier

Alle

Beskrivelse

Inclusion Criteria:

At least 18 years old and has provided informed consent.
Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
Histologically or cytologically confirmed PDAC with metastatic disease.
Evidence of active disease progression during or following the most recent line of systemic therapy for PDAC, based on investigator assessment.
At least one prior line of systemic therapy in the metastatic setting, which must include either a fluoropyrimidine-based or gemcitabine-based regimen.
Received and progressed, been intolerant to prior standard therapy, or no longer expected to benefit from standard therapies.
Adequate bone marrow, renal, hepatic, and coagulation functions.
Ineligible for, or unable to enroll in, another clinical trial of daraxonrasib, if available.
Able to take oral medications

Exclusion Criteria:

History of known central nervous system metastatic disease.
Concurrent systemic anticancer therapy.
Significant cardiovascular disease.
Major GI conditions that may affect the ability to take or absorb daraxonrasib (patients with prior Whipple procedure are eligible).
Active uncontrolled systemic infection.
Major surgery within 28 days before enrollment.
Additional inclusion and exclusion criteria may apply.

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

Revolution Medicines, Inc.

Publikasjoner og nyttige lenker

Den som er ansvarlig for å legge inn informasjon om studien leverer frivillig disse publikasjonene. Disse kan handle om alt relatert til studiet.

Hjelpsomme linker

<p>Related Info</p>

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Datoer for studieregistrering

Først innsendt

1. mai 2026

Først innsendt som oppfylte QC-kriteriene

1. mai 2026

Først lagt ut (Faktiske)

7. mai 2026

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

1. september 2026

Siste oppdatering sendt inn som oppfylte QC-kriteriene

27. august 2026

Sist bekreftet

1. juli 2026

Mer informasjon

Begreper knyttet til denne studien

Nøkkelord

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

RMC-6236-401

Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .