Expanded Access Program for Daraxonrasib (RMC-6236) in Previously Treated Metastatic Pancreatic Adenocarcinoma

August 20, 2026 updated by: Revolution Medicines, Inc.

Expanded Access Program to Treat Patients With Previously Treated Metastatic Pancreatic Adenocarcinoma With Daraxonrasib

This Expanded Access Program (EAP) is intended to provide daraxonrasib to eligible adult patients with previously treated metastatic pancreatic adenocarcinoma, who have no comparable or satisfactory alternative therapy and are unable to participate in an ongoing daraxonrasib clinical trial.

Study Overview

Status

Available

Conditions

Intervention / Treatment

Detailed Description

This EAP has been established to provide access to daraxonrasib to patients with previously treated metastatic pancreatic adenocarcinoma during the period before potential commercial availability. Patients may be eligible if they have progressed on, are intolerant of, or are no longer expected to benefit from available standard therapies, and if they are not able to enroll in a clinical trial of daraxonrasib due to ineligibility or lack of access. This EAP is intended to address an unmet medical need and is not designed to support clinical development objectives.

Daraxonrasib is an investigational, orally administered, RAS(ON) inhibitor administered as monotherapy. Daraxonrasib will be supplied by the Sponsor free of charge during the duration of treatment under this program.

Study Type

Expanded Access

Expanded Access Type

  • Treatment IND/Protocol

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Puerto Rico
      • San Juan, Puerto Rico, 00909
        • Available
        • PanOncology Centre
  • United States
    • Alabama
      • Birmingham, Alabama, United States, 35243
        • Available
        • Alabama Oncology
      • Daphne, Alabama, United States, 36526
        • Available
        • Southern Cancer Center
      • Dothan, Alabama, United States, 36303
        • Available
        • Dothan Hematology and Oncology
      • Fort Payne, Alabama, United States, 35967
        • Available
        • Alabama Cancer Care of Ft Payne
      • Mobile, Alabama, United States, 36608
        • Available
        • Southern Cancer Center
      • Mobile, Alabama, United States, 36604
        • Available
        • USA Health Mitchell Cancer Institute
      • Montgomery, Alabama, United States, 36106
        • Available
        • Montgomery Cancer Center
      • Tuscaloosa, Alabama, United States, 35406
        • Available
        • Alabama Cancer Care of Tuscaloosa
    • Alaska
      • Anchorage, Alaska, United States, 99508
        • Available
        • Alaska Oncology and Hematology
    • Arizona
      • Casa Grande, Arizona, United States, 85122
        • Available
        • Cancer and Blood Specialists of Arizona
      • Goodyear, Arizona, United States, 85338
        • Available
        • City of Hope Phoenix
      • Phoenix, Arizona, United States, 85054
        • Available
        • Mayo Clinic - Arizona
      • Scottsdale, Arizona, United States, 85258
        • Available
        • Honor Health
      • Tucson, Arizona, United States, 85719
        • Available
        • University of Arizona Cancer Center
    • Arkansas
      • Fort Smith, Arkansas, United States, 72903
        • Available
        • Mercy Hospital Fort Smith
      • Hot Springs, Arkansas, United States, 71913
        • Available
        • Genesis Cancer and Blood Institute
      • Little Rock, Arkansas, United States, 72205
        • Available
        • CARTI Cancer Center
    • California
      • Chula Vista, California, United States, 91911
        • Available
        • Care Oncology Center
      • Duarte, California, United States, 91010
        • Available
        • City of Hope Cancer Center (California)
      • Fountain Valley, California, United States, 92708
        • Available
        • Cancer and Blood Specialty Clinics
      • Fresno, California, United States, 93720
        • Available
        • California Cancer Associates for Research and Excellence
      • Fullerton, California, United States, 92835
        • Available
        • Providence St. Jude
      • Greenbrae, California, United States, 94904
        • Available
        • Marin Cancer Care
      • Los Angeles, California, United States, 90048
        • Available
        • Cedars-Sinai Medical Center
      • Los Angeles, California, United States, 90095
        • Available
        • University of California
      • Los Angeles, California, United States, 90033
        • Available
        • USC Norris Comprehensive Cancer Hospital
      • Los Angeles, California, United States, 90095
        • Available
        • UCLA Health Westlake Village
      • Monterey, California, United States, 93940
        • Available
        • Pacific Cancer Care
      • Mountain View, California, United States, 94040
        • Available
        • El Camino Health
      • Oakland, California, United States, 94158
        • Available
        • University of California - San Francisco
      • Orange, California, United States, 92612
        • Available
        • UCI Health
      • Palm Springs, California, United States, 92262
        • Available
        • Desert Care Network Comprehensive Cancer
      • Roseville, California, United States, 95661
        • Available
        • The Kaiser Permanente Medical Group
      • Sacramento, California, United States, 95816
        • Available
        • Sutter Health
      • San Diego, California, United States, 92037
        • Available
        • Scripps Clinic Torrey Pines
      • San Francisco, California, United States, 94115
        • Available
        • Sutter Health
      • San Francisco, California, United States, 94143
        • Available
        • Bakar Precision Cancer Medicine Building
      • San Luis Obispo, California, United States, 93401
        • Available
        • CommonSpirit
      • Santa Rosa, California, United States, 95403
        • Available
        • Providence Medical Foundation
      • Stanford, California, United States, 94305
        • Available
        • Stanford University
      • Vacaville, California, United States, 95687
        • Available
        • NorthBay Health Heidi Y Campini Cancer Center
      • Walnut Creek, California, United States, 94598
        • Available
        • UCSF John Muir Health
    • Colorado
      • Aurora, Colorado, United States, 80012
        • Available
        • Rocky Mountain Cancer Center
      • Colorado Springs, Colorado, United States, 80920
        • Available
        • UC Health Memorial Health System
      • Denver, Colorado, United States, 80210
        • Available
        • AdventHealth Porter
      • Denver, Colorado, United States, 80211
        • Available
        • Intermountain Health
      • Durango, Colorado, United States, 81301
        • Available
        • CommonSpirit Oncology Mercy
      • Fort Collins, Colorado, United States, 80528
        • Available
        • UCHealth Poudre Valley Hospital
    • Connecticut
      • New Haven, Connecticut, United States, 06519
        • Available
        • Yale New Haven Hospital
      • Norwalk, Connecticut, United States, 06856
        • Available
        • Norwalk Hospital
      • Norwich, Connecticut, United States, 06360
        • Available
        • Eastern Connecticut Hematology and Oncology
    • Florida
      • Boca Raton, Florida, United States, 33487
        • Available
        • Lynn Cancer Institute - Boca Raton Regional Hospital
      • Brooksville, Florida, United States, 36413
        • Available
        • Advanced Cancer Treatment Centers
      • Hollywood, Florida, United States, 33021
        • Available
        • Memorial Cancer Institute
      • Jacksonville, Florida, United States, 32224
        • Available
        • Mayo Clinic - Florida
      • Jacksonville, Florida, United States, 32256
        • Available
        • Cancer Specialists of North Florida
      • Miami, Florida, United States, 33176
        • Available
        • Baptist Hospital of Miami
      • Miami, Florida, United States, 33136
        • Available
        • Sylvester Comprehensive Cancer Center
      • Miami Beach, Florida, United States, 33140
        • Available
        • Mount Sinai Medical Center of Florida
      • Naples, Florida, United States, 32746
        • Available
        • Florida Cancer Specialists and Research Institute
      • Orlando, Florida, United States, 32803
        • Available
        • Advent Health
      • Orlando, Florida, United States, 33308
        • Available
        • Holy Cross Health - Phil Smith Neuroscience Institute ALS Multidisciplinary Clinic
      • Pensacola, Florida, United States, 32504
        • Available
        • Ascension Sacred Heart
      • Sarasota, Florida, United States, 34232
        • Available
        • Intercoastal Medical Group
      • Tampa, Florida, United States, 33612
        • Available
        • Moffitt Cancer Center
      • Tampa, Florida, United States, 33606
        • Available
        • Tampa General Hospital
    • Georgia
      • Atlanta, Georgia, United States, 30322
        • Available
        • Emory University Hospital
      • Atlanta, Georgia, United States, 30318
        • Available
        • Piedmont Physicians Medical Oncology
      • Atlanta, Georgia, United States, 30318
        • Available
        • Piedmont Cancer Institute - Atlanta
      • Atlanta, Georgia, United States, 30342
        • Available
        • North Side Hospital - Atlanta Cancer Care
      • Columbus, Georgia, United States, 31904
        • Available
        • Piedmont Columbus Regional Midtown
      • Macon, Georgia, United States, 31210
        • Available
        • Central Georgia Cancer Care
      • Marietta, Georgia, United States, 30060
        • Available
        • Northwest Georgia Oncology Centers
    • Hawaii
      • Honolulu, Hawaii, United States, 96813
        • Available
        • The Queen's Medical Center
      • Honolulu, Hawaii, United States, 96814
        • Available
        • Hawai'i Pacific Health
    • Idaho
      • Boise, Idaho, United States, 83712
        • Available
        • St Luke's Cancer Institute
      • Post Falls, Idaho, United States, 83854
        • Available
        • Beacon Clinic
    • Illinois
      • Arlington Heights, Illinois, United States, 60005
        • Available
        • Illinois Cancer Specialist
      • Chicago, Illinois, United States, 60611
        • Available
        • Northwestern University
      • Chicago, Illinois, United States, 60637
        • Available
        • University of Chicago Medical Center
      • Downers Grove, Illinois, United States, 60515
        • Available
        • Advocate Health Care
      • Naperville, Illinois, United States, 60126
        • Available
        • Endeavor Health Cancer Institute
      • Peoria, Illinois, United States, 61637
        • Available
        • OSF Cancer Institute
      • Peoria, Illinois, United States, 61615
        • Available
        • Illinois CancerCare
      • Quincy, Illinois, United States, 62301
        • Available
        • Blessing Hospital
      • Rolling Meadows, Illinois, United States, 60008
        • Available
        • Northwest Oncology & Hematology
      • Zion, Illinois, United States, 60099
        • Available
        • City of Hope Chicago
    • Indiana
      • Fort Wayne, Indiana, United States, 46845
        • Available
        • Parkview Packnett Family Cancer Institute
      • Indianapolis, Indiana, United States, 46202
        • Available
        • Indiana University School of Medicine
      • Indianapolis, Indiana, United States, 46237
        • Available
        • Franciscan Alliance Health
      • Newburgh, Indiana, United States, 47630
        • Available
        • Deaconess Health System
      • Newburgh, Indiana, United States, 47630
        • Available
        • Ascension Medical Group St. Vincent
    • Iowa
      • Ames, Iowa, United States, 50010
        • Available
        • McFarland Clinic
      • Bettendorf, Iowa, United States, 52722
        • Available
        • University of Iowa Cancer Services Quad Cities
      • Cedar Rapids, Iowa, United States, 52403
        • Available
        • Mercy Medical Center
      • Waukee, Iowa, United States, 50263
        • Available
        • University of Iowa
    • Kansas
      • Merriam, Kansas, United States, 66204
        • Available
        • Advent Health Shawnee Mission
      • Westwood, Kansas, United States, 66205
        • Available
        • University of Kansas Medical Center
      • Wichita, Kansas, United States, 67214
        • Available
        • Cancer Center of Kansas
    • Kentucky
      • Edgewood, Kentucky, United States, 41017
        • Available
        • St. Elizabeth Healthcare
      • Lexington, Kentucky, United States, 40503
        • Available
        • Baptist Health Lexington
      • Louisville, Kentucky, United States, 40217
        • Available
        • Norton Cancer Institute
      • Owensboro, Kentucky, United States, 42303
        • Available
        • Owensboro Health Mitchell Memorial Cancer Center
      • Paducah, Kentucky, United States, 42003
        • Available
        • Mercy Health - Paducah Cancer Center
    • Louisiana
      • New Orleans, Louisiana, United States, 70112
        • Available
        • LSU LCMC Health Cancer Center
      • New Orleans, Louisiana, United States, 70121
        • Available
        • Ochsner Health System
      • Shreveport, Louisiana, United States, 71103
        • Available
        • Willis Knighton Cancer Center
    • Maine
      • Topsham, Maine, United States, 04086
        • Available
        • New England Cancer Specialists
    • Maryland
      • Baltimore, Maryland, United States, 21231
        • Available
        • Johns Hopkins
      • Frederick, Maryland, United States, 21701
        • Available
        • Frederick Health
    • Massachusetts
      • Boston, Massachusetts, United States, 02114
        • Available
        • Massachusetts General Hospital
      • Boston, Massachusetts, United States, 02215
        • Available
        • Beth Israel Deaconess Medical Center
      • Boston, Massachusetts, United States, 02215
        • Available
        • Dana Farber Cancer Institute
      • Burlington, Massachusetts, United States, 01805
        • Available
        • Lahey Clinic
      • Natick, Massachusetts, United States, 01760
        • Available
        • Mountain Health Clinic
      • Worcester, Massachusetts, United States, 01655
        • Available
        • UMass Memorial Medical Center
    • Michigan
      • Ann Arbor, Michigan, United States, 48109
        • Available
        • University of Michigan
      • Detroit, Michigan, United States, 48201
        • Available
        • Karmanos Cancer Institute (Barbara Ann Karmanos Cancer Hospital)
      • Detroit, Michigan, United States, 48202
        • Available
        • Henry Ford Health
      • Grand Rapids, Michigan, United States, 49546
        • Available
        • The Cancer & Hematology Centers
      • Royal Oak, Michigan, United States, 48073
        • Available
        • Hematology Oncology Consultants
      • Saginaw, Michigan, United States, 48604
        • Available
        • Covenant HealthCare
      • Ypsilanti, Michigan, United States, 48197
        • Available
        • Trinity Health Hospital
    • Minnesota
      • Duluth, Minnesota, United States, 55805
        • Available
        • Essentia Health
      • Edina, Minnesota, United States, 55435
        • Available
        • USOR: Minnesota Oncology Hematology, PA
      • Rochester, Minnesota, United States, 55905
        • Available
        • Mayo Clinic Minnesota
      • Saint Louis Park, Minnesota, United States, 55426
        • Available
        • Park Nicollet Specialty Center
      • Saint Louis Park, Minnesota, United States, 55426
        • Available
        • Health Partners Frauenshuh Cancer Center
      • Saint Louis Park, Minnesota, United States, 55426
        • Available
        • HealthPartners Frauenshuh Cancer Center
      • Saint Paul, Minnesota, United States, 55101
        • Available
        • Health Partners Oncology
    • Mississippi
      • Jackson, Mississippi, United States, 39202
        • Available
        • Jackson Oncology Associates
    • Missouri
      • Columbia, Missouri, United States, 65212
        • Available
        • University Hospital - MU Health Care
      • Joplin, Missouri, United States, 64804
        • Available
        • Mercy Hospital Joplin
      • Kansas City, Missouri, United States, 64111
        • Available
        • Saint Luke's Hospital of Kansas City
      • Kansas City, Missouri, United States, 64132
        • Available
        • Mid America Cancer Care
      • Springfield, Missouri, United States, 65807
        • Available
        • Oncology Hematology Associates
      • Springfield, Missouri, United States, 65807
        • Available
        • Mercy Hospital Springfield
      • St Louis, Missouri, United States, 63141
        • Available
        • Washington University School of Medicine
      • St Louis, Missouri, United States, 63128
        • Available
        • Mercy Hospital St. Louis-South
      • St Louis, Missouri, United States, 63141
        • Available
        • Pratt Cancer Center
    • Montana
      • Kalispell, Montana, United States, 59901
        • Available
        • Logan Health
    • Nebraska
      • Lincoln, Nebraska, United States, 68506
        • Available
        • NHO Revive Research Institute
      • Omaha, Nebraska, United States, 68130
        • Available
        • Nebraska Cancer Specialists
      • Omaha, Nebraska, United States, 68114
        • Available
        • University of Nebraska Medical Center
    • New Hampshire
      • Lebanon, New Hampshire, United States, 03756
        • Available
        • Dartmouth Hitchcock Medical Center
    • New Jersey
      • Camden, New Jersey, United States, 08103
        • Available
        • MD Anderson at Cooper
      • Florham Park, New Jersey, United States, 07932
        • Available
        • Summit Health
      • Marlton, New Jersey, United States, 08053
        • Available
        • Lindenberg Cancer & Hematology Center
      • Morristown, New Jersey, United States, 07960
        • Available
        • Overlook Medical Center - Medical Diagnostic Associates - Atlantic Medical Group
      • New Brunswick, New Jersey, United States, 08903
        • Available
        • Rutgers Cancer Institute
      • Toms River, New Jersey, United States, 08755
        • Available
        • Community Medical Center
    • New York
      • Albany, New York, United States, 12206
        • Available
        • New York Oncology Hematology
      • Brooklyn, New York, United States, 11206
        • Available
        • Hirschfeld Oncology
      • Brooklyn, New York, United States, 11215
        • Available
        • Dosik Hematology and Oncology
      • Lake Success, New York, United States, 11042
        • Available
        • Northwell Health
      • Long Island City, New York, United States, 11101
        • Available
        • Memorial Sloan Kettering Cancer Center
      • New York, New York, United States, 10032
        • Available
        • Columbia University Irving Medical Center
      • New York, New York, United States, 10016
        • Available
        • NYU Langone Health
      • New York, New York, United States, 10029
        • Available
        • The Mount Sinai Hospital
      • New York, New York, United States, 11967
        • Available
        • New York Cancer and Blood Specialists
      • New York, New York, United States, 10022
        • Available
        • Columbia University
      • Rochester, New York, United States, 14626
        • Available
        • Rochester Regional Health
      • Stony Brook, New York, United States, 11794
        • Available
        • Stony Brook University Hospital
      • The Bronx, New York, United States, 10461
        • Available
        • Montefiore Medical Center
    • North Carolina
      • Charlotte, North Carolina, United States, 28204
        • Available
        • Atrium Health
      • Durham, North Carolina, United States, 27710
        • Available
        • Duke Cancer Institute
      • Huntersville, North Carolina, United States, 28078
        • Available
        • Carolina BioOncology Institute
      • Winston-Salem, North Carolina, United States, 27157
        • Available
        • Wake Forest University Health Sciences
    • North Dakota
      • Fargo, North Dakota, United States, 58102
        • Available
        • Sanford Roger Maris Cancer Center
    • Ohio
      • Canfield, Ohio, United States, 44406
        • Available
        • Blood and Cancer Center
      • Canton, Ohio, United States, 44170
        • Available
        • Aultman Hospital
      • Cincinnati, Ohio, United States, 45242
        • Available
        • OHC (Oncology Hematology Care)
      • Cleveland, Ohio, United States, 44106
        • Available
        • University Hospitals Cleveland Medical Center
      • Cleveland, Ohio, United States, 44106
        • Available
        • UH Seidman Cancer Centre
      • Cleveland, Ohio, United States, 95000
        • Available
        • Cleveland Clinic Foundation
      • Columbus, Ohio, United States, 43214
        • Available
        • OhioHealth Mansfield Hospital
      • Columbus, Ohio, United States, 43219
        • Available
        • Zangmeister Cancer Center
      • Columbus, Ohio, United States, 43214
        • Available
        • Ohio Health
      • Columbus, Ohio, United States, 43221
        • Available
        • The Ohio State University Wexner Medical Center
      • Columbus, Ohio, United States, 43214
        • Available
        • Jasonway Cancer Center
      • Dayton, Ohio, United States, 45459
        • Available
        • Premier Health OH
      • Kettering, Ohio, United States, 45429
        • Available
        • Kettering Health Cancer Center
      • Middletown, Ohio, United States, 45005
        • Available
        • Premier Health OH
    • Oklahoma
      • Oklahoma City, Oklahoma, United States, 73120
        • Available
        • Mercy Hospital Oklahoma City
      • Oklahoma City, Oklahoma, United States, 73104
        • Available
        • OU Health Science Center - Stephenson Cancer Center
    • Oregon
      • Corvallis, Oregon, United States, 97330
        • Available
        • Samaritan Hemotology and Oncology
      • Happy Valley, Oregon, United States, 97223
        • Available
        • Compass Oncology
      • Portland, Oregon, United States, 97213
        • Available
        • Providence Medical Center
      • Salem, Oregon, United States, 97301
        • Available
        • Oregon Oncology Specialists
      • Springfield, Oregon, United States, 97477
        • Available
        • Willamette Valley Cancer Institute
    • Pennsylvania
      • Allentown, Pennsylvania, United States, 18103
        • Available
        • Lehigh Valley Hospital
      • Bethlehem, Pennsylvania, United States, 18015
        • Available
        • St. Luke's University Health Network
      • Bryn Mawr, Pennsylvania, United States, 19010
        • Available
        • Bryn Mawr Hospital
      • Butler, Pennsylvania, United States, 15212
        • Available
        • Allegheny Health Network Cancer Institute
      • Dunmore, Pennsylvania, United States, 18512
        • Available
        • Hematology & Oncology Associates of NEPA
      • Media, Pennsylvania, United States, 19063
        • Available
        • Alliance Cancer Specialists
      • Natrona Heights, Pennsylvania, United States, 15212
        • Available
        • Allegheny Valley Hospital
      • Paoli, Pennsylvania, United States, 19301
        • Available
        • Paoli Hospital
      • Philadelphia, Pennsylvania, United States, 19111
        • Available
        • Fox Chase Cancer Center
      • Philadelphia, Pennsylvania, United States, 19104
        • Available
        • University of Pennsylvania
      • Philadelphia, Pennsylvania, United States, 19107
        • Available
        • Thomas Jefferson University Hospital
      • Pittsburgh, Pennsylvania, United States, 15224
        • Available
        • University of Pittsburgh Medical Center (UPMC)
      • Pittsburgh, Pennsylvania, United States, 15224
        • Available
        • UPMC Western Maryland
      • Sayre, Pennsylvania, United States, 18840
        • Available
        • Guthrie Sayre
      • West Mifflin, Pennsylvania, United States, 15122
        • Available
        • UPMC Hillman Cancer Center
      • Wynnewood, Pennsylvania, United States, 19096
        • Available
        • Lankenau Medical Center
    • Rhode Island
      • Providence, Rhode Island, United States, 02903
        • Available
        • Rhode Island Hospital
    • South Carolina
      • Charleston, South Carolina, United States, 29414
        • Available
        • Bon Secours St. Francis Cancer Center
      • Florence, South Carolina, United States, 29506
        • Available
        • McLeod Health
      • Greer, South Carolina, United States, 29651
        • Available
        • Spartanburg Regional Healthcare System - Gibbs Cancer Center & Research Institute
    • South Dakota
      • Rapid City, South Dakota, United States, 57701
        • Available
        • Monument Health Cancer Care Institute
      • Sioux Falls, South Dakota, United States, 57105
        • Available
        • Avera Cancer Institute
      • Sioux Falls, South Dakota, United States, 57104
        • Available
        • Sanford Health
    • Tennessee
      • Germantown, Tennessee, United States, 38138
        • Available
        • West Cancer Center
      • Knoxville, Tennessee, United States, 37919
        • Available
        • Tennessee Cancer Specialists
      • Memphis, Tennessee, United States, 38120
        • Available
        • Baptist Cancer Center
      • Nashville, Tennessee, United States, 37203
        • Available
        • Tennessee Oncology
      • Nashville, Tennessee, United States, 37203
        • Available
        • Sarah Cannon Cancer Institute
    • Texas
      • Dallas, Texas, United States, 75390
        • Available
        • University of Texas Southwestern Medical
      • Edinburg, Texas, United States, 78539
        • Available
        • DHR Health
      • Fort Bliss, Texas, United States, 79918
        • Available
        • William Beaumont Army Medical Center - Fort Bliss
      • Houston, Texas, United States, 77030
        • Available
        • MD Anderson Cancer Center
      • Houston, Texas, United States, 77030
        • Available
        • Houston Methodist Hospital- Cancer Center
      • Houston, Texas, United States, 77024
        • Available
        • American Oncology Network - Oncology Consultants
      • Lubbock, Texas, United States, 79410
        • Available
        • Covenant Health - Joe Arrington Cancer Research and Treatment Center
      • Pearland, Texas, United States, 77584
        • Available
        • Texas Oncology
      • Richardson, Texas, United States, 75082
        • Available
        • Methodist Richardson Cancer Center
      • San Antonio, Texas, United States, 78229
        • Available
        • UT Health San Antonio MD Anderson Cancer Center
      • Temple, Texas, United States, 76508
        • Available
        • Baylor Scott & White Health
    • Utah
      • Ogden, Utah, United States, 84405
        • Available
        • Ogden Clinic
      • Salt Lake City, Utah, United States, 84106
        • Available
        • Utah Cancer Specialists (UCS)
      • Salt Lake City, Utah, United States, 84112
        • Available
        • Huntsman Cancer Institute & Hospital
    • Vermont
      • Burlington, Vermont, United States, 05401
        • Available
        • University of Vermont Medical Center
    • Virginia
      • Fairfax, Virginia, United States, 22031
        • Available
        • Virginia Cancer Specialists
      • Fairfax, Virginia, United States, 22031
        • Available
        • Inova Schar Cancer
      • Fredericksburg, Virginia, United States, 22408
        • Available
        • Hematology Oncology Associates of Fredericksburg
      • Hampton, Virginia, United States, 23606
        • Available
        • Virginia Oncology Associates
      • Newport News, Virginia, United States, 23320
        • Available
        • Riverside Health
      • Richmond, Virginia, United States, 23229
        • Available
        • Virginia Cancer Institute
      • Richmond, Virginia, United States, 23219
        • Available
        • VCU Health
    • Washington
      • Kennewick, Washington, United States, 99336
        • Available
        • Kadlec Regional Medical Center
      • Renton, Washington, United States, 98057
        • Available
        • Seattle Integrative Cancer Center
      • Seattle, Washington, United States, 98101
        • Available
        • Virginia Mason Medical Center
      • Seattle, Washington, United States, 98104
        • Available
        • Swedish Cancer Institute Treatment Center
      • Seattle, Washington, United States, 98109
        • Available
        • Fred Hutch Cancer Center
      • Seattle, Washington, United States, 98104
        • Available
        • Providence Swedish Cancer Institute
      • Walla Walla, Washington, United States, 99362
        • Available
        • Providence St. Mary Medical Center
    • Wisconsin
      • Appleton, Wisconsin, United States, 54611
        • Available
        • ThedaCare Regional Cancer Center
      • Grafton, Wisconsin, United States, 53024
        • Available
        • Aurora Medical Center
      • Green Bay, Wisconsin, United States, 54303
        • Available
        • HSHS St. Mary's Hospital Medical Center
      • Green Bay, Wisconsin, United States, 54313
        • Available
        • Bellin Health
      • La Crosse, Wisconsin, United States, 05461
        • Available
        • Emplify Health by Gundersen
      • Madison, Wisconsin, United States, 53792
        • Available
        • University of Wisconsin
      • Marshfield, Wisconsin, United States, 54449
        • Available
        • Marshfield Medical Center
      • Milwaukee, Wisconsin, United States, 53226
        • Available
        • Medical College of Wisconsin
      • Waukesha, Wisconsin, United States, 53072
        • Available
        • UW Health Cancer Center at ProHealth Care

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

N/A

Description

Inclusion Criteria:

  • At least 18 years old and has provided informed consent.
  • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
  • Histologically or cytologically confirmed PDAC with metastatic disease.
  • Evidence of active disease progression during or following the most recent line of systemic therapy for PDAC, based on investigator assessment.
  • At least one prior line of systemic therapy in the metastatic setting, which must include either a fluoropyrimidine-based or gemcitabine-based regimen.
  • Received and progressed, been intolerant to prior standard therapy, or no longer expected to benefit from standard therapies.
  • Adequate bone marrow, renal, hepatic, and coagulation functions.
  • Ineligible for, or unable to enroll in, another clinical trial of daraxonrasib, if available.
  • Able to take oral medications

Exclusion Criteria:

  • History of known central nervous system metastatic disease.
  • Concurrent systemic anticancer therapy.
  • Significant cardiovascular disease.
  • Major GI conditions that may affect the ability to take or absorb daraxonrasib (patients with prior Whipple procedure are eligible).
  • Active uncontrolled systemic infection.
  • Major surgery within 28 days before enrollment.
  • Additional inclusion and exclusion criteria may apply.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Revolution Medicines, Inc.

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

First Submitted

May 1, 2026

First Submitted That Met QC Criteria

May 1, 2026

First Posted (Actual)

May 7, 2026

Study Record Updates

Last Update Posted (Actual)

August 24, 2026

Last Update Submitted That Met QC Criteria

August 20, 2026

Last Verified

July 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • RMC-6236-401

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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