Exercise Intervention for Chemotherapy-Induced Peripheral Neuropathy
3. juni 2026 opdateret af: Seethalakshmi Avudaiappan, Sri Ramachandra Institute of Higher Education and Research
Prevalence and Effectiveness of Exercise on Chemotherapy-induced Peripheral Neuropathy Among Oncology Patients
Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect of chemotherapy that can negatively impact patients' functional status and quality of life.
This study was conducted in two phases among oncology patients receiving chemotherapy at a tertiary care teaching hospital in Chennai, India.
Phase I used a descriptive survey design to determine the prevalence of CIPN.
Phase II employed a randomized controlled experimental design to evaluate the effectiveness of a structured exercise program in reducing CIPN symptoms among patients with mild to moderate CIPN.
Eligible participants were randomly assigned to intervention and control groups.
The intervention group received education and supervised exercises involving lower and upper extremity movements, while the control group received routine care.
Outcomes were assessed using the Chemotherapy-Induced Peripheral Neuropathy Assessment Scale before and after a 21-day intervention period.
Studieoversigt
Status
Afsluttet
Intervention / Behandling
Detaljeret beskrivelse
This quantitative study was conducted in two phases. Phase I assessed the prevalence of chemotherapy-induced peripheral neuropathy among oncology patients receiving chemotherapy. A total of 282 participants were enrolled.
Based on the prevalence findings, Phase II was conducted to determine the effectiveness of a structured exercise program. One hundred and twenty patients with mild or moderate CIPN were randomly allocated into intervention (n=60) and control (n=60) groups using a lottery method. The intervention consisted of education regarding CIPN and a structured exercise program including toe flexion and extension, ankle circles, toe spreading, heel raises, finger extension stretches, pinch grips, and finger circles. Exercises were performed 10-15 repetitions per extremity, 2-3 times daily, for 21 days.
Participants in the control group received routine oncology care. CIPN severity was measured before and after the intervention using the Chemotherapy-Induced Peripheral Neuropathy Assessment Scale. Statistical analyses included descriptive statistics, paired t-tests, independent t-tests, and chi-square tests.
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
282
Fase
- Ikke anvendelig
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
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Tamil Nadu
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Chennai, Tamil Nadu, Indien, 600116
- Sri Ramachandra Institute of Higher Education and Research
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Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
- Voksen
- Ældre voksen
Tager imod sunde frivillige
Ingen
Beskrivelse
Inclusion Criteria:
- Age greater than 18 years
- Receiving chemotherapy
- Diagnosed with mild or moderate chemotherapy-induced peripheral neuropathy
- Willing to participate and provide informed consent
Exclusion Criteria:
- Pre-existing peripheral neuropathy unrelated to chemotherapy (e.g., diabetic neuropathy).
- Uncontrolled diabetes mellitus.
- Significant cardiovascular disease.
- Severe musculoskeletal disorders.
- Contraindications to exercise, including recent surgery, bone metastases, or severe anemia.
- Severe mobility limitations.
- Severe mental health conditions affecting participation.
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
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Eksperimentel: Experimental Arm: Structured Exercise Program
Participants received structured education regarding chemotherapy-induced peripheral neuropathy and performed a supervised exercise program involving lower and upper extremity exercises for 21 days in addition to routine care.
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Patients in the intervention group receive structured education about CIPN, which included its definition, risk factors, signs and symptoms, and management through exercises.
The exercises were demonstrated by the researcher and involved leg toe flexion and extension, ankle circles, toe spreading, heel raises, as well as hand exercises such as finger extension stretches, pinch grips, and finger circles.
Participants were asked to return demonstrate the exercises, continue practicing them under supervision for one to two days during hospitalization for chemotherapy and after discharge for a period of 21 days when they came for their subsequent cycle of chemotherapy.
This was then reinforced using a pamphlet which was provided to the patients, and patients were encouraged to maintain a daily practice
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Ingen indgriben: Control Arm: Routine Care
Participants received standard oncology care including consultation and medication management according to institutional protocols.
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
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Severity of Chemotherapy-Induced Peripheral Neuropathy
Tidsramme: Baseline and Day 21
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Change in CIPN severity score measured using the Chemotherapy-Induced Peripheral Neuropathy Assessment Scale from baseline to Day 21.
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Baseline and Day 21
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Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
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Prevalence of Chemotherapy-Induced Peripheral Neuropathy among oncology patients receiving chemotherapy.
Tidsramme: At baseline assessment.
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Prescence of CIPN and its severity score measured using the Chemotherapy-Induced Peripheral Neuropathy Assessment Scale from baseline to Day 21.
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At baseline assessment.
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Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
1. oktober 2024
Primær færdiggørelse (Faktiske)
1. december 2024
Studieafslutning (Faktiske)
1. december 2024
Datoer for studieregistrering
Først indsendt
3. juni 2026
Først indsendt, der opfyldte QC-kriterier
3. juni 2026
Først opslået (Faktiske)
9. juni 2026
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
9. juni 2026
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
3. juni 2026
Sidst verificeret
1. juni 2026
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- 05/185
Plan for individuelle deltagerdata (IPD)
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INGEN
IPD-planbeskrivelse
Individual participant data will not be publicly shared.
De-identified data may be available from the corresponding investigator upon reasonable request.
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Kliniske forsøg med Structured exercise program for CIPN
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