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Improving the Reliability of LLMs as Medical Assistants for the General Public (LAMP-1)

11. juni 2026 opdateret af: Ji Xunming,MD,PhD, Capital Medical University

Improving the Reliability of LLMs as Medical Assistants for the General Public: a Proof of Concept Simulation Trial

This study will evaluate whether three-minute six-dimensions education(3M-6D education) can improve the reliability of large language models as medical assistants for the general public. Participants will be randomly assigned to receive or not receive 3M-6D education and then use ChatGPT, Gemini, or non-AI information resources. The study will assess relevant condition identification, disposition concordance, red-flag identification, and NASA-TLX score.

Studieoversigt

Status

Ikke rekrutterer endnu

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

This randomized, controlled, proof-of-concept simulation trial will evaluate whether three-minute six-dimensions education (3M-6D education) can improve the reliability of large language models as medical assistants for the general public.

Eligible participants will be randomly assigned in a 1:1:1:1:1 ratio to one of five study groups: the 3M-6D education GPT group, the GPT group, the 3M-6D education Gemini group, the Gemini group, or the control group. Participants in the 3M-6D education GPT and 3M-6D education Gemini groups will receive approximately three minutes of education before using ChatGPT or Gemini.Each participant will be randomly assigned one of 10 standardized clinical scenarios and complete a simulated counseling task in unrestricted natural language within approximately 10 minutes. The study will assess relevant condition identification, disposition concordance, red-flag identification, and NASA-TLX score.

Undersøgelsestype

Interventionel

Tilmelding (Anslået)

525

Fase

  • Ikke anvendelig

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiekontakt

Undersøgelse Kontakt Backup

Studiesteder

  • Kina
    • Beijing Municipality
      • Beijing, Beijing Municipality, Kina, 100053
        • Xuanwu Hospital, Capital Medical University
        • Kontakt:

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Voksen
  • Ældre voksen

Tager imod sunde frivillige

Ja

Beskrivelse

Inclusion Criteria:

  1. Age 18 years or greater, male or female;
  2. Completed primary school or higher education;
  3. Able to use a smartphone or computer to complete online interaction;
  4. No history of acute ischemic stroke, systemic lupus erythematosus, gastric ulcer, pneumonia, acute cardiac infarction, urinary tract infection, uterine fibroids, diabetes, osteoarthritis, or migraine.
  5. Able to understand and comply with study procedures and to provide written informed consent.

Exclusion Criteria:

  1. Currently or previously employed as a healthcare worker;
  2. Previously received systematic medical training;
  3. Currently involved in concurrent research that may interfere with the results of the present trial;
  4. The investigator considered that the participant had other conditions that might affect compliance or preclude participation.

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Sundhedstjenesteforskning
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Enkelt

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Eksperimentel: 3M-6D education GPT Group
Participants will first be trained in 3M-6D education, then use ChatGPT to complete a consultation task in unrestricted natural language in approximately 10 minutes.
Adfærdsmæssigt: three minutes six dimensions education

3M-6D education is designed based on Cognitive Load Theory to reduce the cognitive burden on patients during medical interactions with AI and to improve the clarity and completeness of symptom reporting.

Guided by cognitive load theory and the natural process physicians use to take medical histories, we identified candidate information dimensions and developed a structured expression framework with six dimensions for public health queries through a Delphi expert consensus process. Participants were instructed to use the framework to describe their symptoms across these six dimensions; this process can typically be completed within three minutes, so we call this approach three minutes six dimensions education (3M-6D education).

Andet: ChatGPT
Participants use ChatGPT to complete a standardized simulated clinical scenarios in unrestricted natural language.
Eksperimentel: 3M-6D education Gemini Group
Participants will first be trained in 3M-6D education, then use Gemini to complete a consultation task in unrestricted natural language in approximately 10 minutes.
Adfærdsmæssigt: three minutes six dimensions education

3M-6D education is designed based on Cognitive Load Theory to reduce the cognitive burden on patients during medical interactions with AI and to improve the clarity and completeness of symptom reporting.

Guided by cognitive load theory and the natural process physicians use to take medical histories, we identified candidate information dimensions and developed a structured expression framework with six dimensions for public health queries through a Delphi expert consensus process. Participants were instructed to use the framework to describe their symptoms across these six dimensions; this process can typically be completed within three minutes, so we call this approach three minutes six dimensions education (3M-6D education).

Andet: Gemini
Participants use Gemini to complete a standardized simulated clinical scenarios in unrestricted natural language.
Aktiv komparator: GPT Group
Participants will use ChatGPT to complete a consultation task in unrestricted natural language in approximately 10 minutes.
Andet: ChatGPT
Participants use ChatGPT to complete a standardized simulated clinical scenarios in unrestricted natural language.
Aktiv komparator: Gemini Group
Participants will use Gemini to complete a consultation task in unrestricted natural language in approximately 10 minutes.
Andet: Gemini
Participants use Gemini to complete a standardized simulated clinical scenarios in unrestricted natural language.
Ingen indgriben: Control group
Participants will use non-AI tools such as internet searches and medical websites to complete a consultation task in unrestricted natural language in approximately 10 minutes.

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Relevant conditions identification of the 3M-6D education GPT group compared with the GPT group
Tidsramme: Usually within 1 hour.
Relevant conditions identification is defined as the proportion of participants whose final response includes the expert-defined final diagnosis or a relevant differential diagnosis.
Usually within 1 hour.
Disposition concordance of the 3M-6D education GPT group compared with the GPT group
Tidsramme: Usually within 1 hour.
Disposition concordance is defined as the proportion of participants whose final care recommendation matches the expert-defined level. The five levels are self-care, routine outpatient care, urgent outpatient care, emergency department visit, and emergency medical services.
Usually within 1 hour.
Relevant conditions identification of the 3M-6D education Gemini group compared with the Gemini group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Disposition concordance of the 3M-6D education Gemini group compared with the Gemini group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Relevant conditions identification of the 3M-6D education GPT group compared with the control group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Relevant conditions identification of the 3M-6D education Gemini group compared with the control group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Disposition concordance of the 3M-6D education GPT group compared with the control group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Disposition concordance of the 3M-6D education Gemini group compared with the control group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Red-flag identification in the 3M-6D education GPT group compared with the GPT group
Tidsramme: Usually within 1 hour.
Red-flag identification is defined as the proportion of participants whose final response includes the key warning signs that experts defined for the assigned scenario.
Usually within 1 hour.
Red-flag identification in the 3M-6D education GPT group compared with the control group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Red-flag identification in the 3M-6D education Gemini group compared with the Gemini group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Red-flag identification in the 3M-6D education Gemini group compared with the control group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
NASA Task Load Index score of the 3M-6D education GPT group compared with the GPT group
Tidsramme: Usually within 1 hour.
NASA-TLX score is a self-reported task-load score measured after the simulated consultation with a physician. It includes six domains: mental demand, physical demand, temporal demand, effort, frustration, and performance. Each domain is scored from 0 to 100. The total score is the mean of the six domains. Higher scores indicate greater perceived task load.
Usually within 1 hour.
NASA Task Load Index score of the 3M-6D education GPT group compared with the control group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
NASA Task Load Index score of the 3M-6D education Gemini group compared with the Gemini group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
NASA Task Load Index score of the 3M-6D education Gemini group compared with the control group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Relevant conditions identification of the 3M-6D education GPT group compared with the 3M-6D education Gemini group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Disposition concordance of the 3M-6D education GPT group compared with the 3M-6D education Gemini group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Red-flag identification in the 3M-6D education GPT group compared with the 3M-6D education Gemini group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
NASA Task Load Index score of the 3M-6D education GPT group compared with the 3M-6D education Gemini group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.

Andre resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Failure to identify red flags in the 3M-6D education GPT group compared with the GPT group
Tidsramme: Usually within 1 hour.
Failure to identify red flags is defined as the proportion of participants whose final response does not include the expert-defined red-flag symptoms or warning signs for the assigned standardized simulated clinical scenario.
Usually within 1 hour.
Failure to identify red flags in the 3M-6D education GPT group compared with the control group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Failure to identify red flags in the 3M-6D education Gemini group compared with the Gemini group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Failure to identify red flags in the 3M-6D education Gemini group compared with the control group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Underestimation of disposition in the 3M-6D education GPT group compared with the GPT group
Tidsramme: Usually within 1 hour.
Underestimation of disposition is defined as the proportion of participants whose final care recommendation is lower than the expert-defined disposition level for the assigned standardized simulated clinical scenario.
Usually within 1 hour.
Underestimation of disposition in the 3M-6D education GPT group compared with the control group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Underestimation of disposition in the 3M-6D education Gemini group compared with the Gemini group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Underestimation of disposition in the 3M-6D education Gemini group compared with the control group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Capital Medical University

Samarbejdspartnere

Xuanwu Hospital, Beijing

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Anslået)

20. juni 2026

Primær færdiggørelse (Anslået)

20. juli 2026

Studieafslutning (Anslået)

20. juli 2026

Datoer for studieregistrering

Først indsendt

11. juni 2026

Først indsendt, der opfyldte QC-kriterier

11. juni 2026

Først opslået (Faktiske)

16. juni 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

16. juni 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

11. juni 2026

Sidst verificeret

1. juni 2026

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Andre undersøgelses-id-numre

  • LAMP-1

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