Improving the Reliability of LLMs as Medical Assistants for the General Public (LAMP-1)
11 июня 2026 г. обновлено: Ji Xunming,MD,PhD, Capital Medical University
Improving the Reliability of LLMs as Medical Assistants for the General Public: a Proof of Concept Simulation Trial
This study will evaluate whether three-minute six-dimensions education(3M-6D education) can improve the reliability of large language models as medical assistants for the general public.
Participants will be randomly assigned to receive or not receive 3M-6D education and then use ChatGPT, Gemini, or non-AI information resources.
The study will assess relevant condition identification, disposition concordance, red-flag identification, and NASA-TLX score.
Обзор исследования
Статус
Еще не набирают
Вмешательство/лечение
Подробное описание
This randomized, controlled, proof-of-concept simulation trial will evaluate whether three-minute six-dimensions education (3M-6D education) can improve the reliability of large language models as medical assistants for the general public.
Eligible participants will be randomly assigned in a 1:1:1:1:1 ratio to one of five study groups: the 3M-6D education GPT group, the GPT group, the 3M-6D education Gemini group, the Gemini group, or the control group. Participants in the 3M-6D education GPT and 3M-6D education Gemini groups will receive approximately three minutes of education before using ChatGPT or Gemini.Each participant will be randomly assigned one of 10 standardized clinical scenarios and complete a simulated counseling task in unrestricted natural language within approximately 10 minutes. The study will assess relevant condition identification, disposition concordance, red-flag identification, and NASA-TLX score.
Тип исследования
Интервенционный
Регистрация (Оцененный)
525
Фаза
- Непригодный
Контакты и местонахождение
В этом разделе приведены контактные данные лиц, проводящих исследование, и информация о том, где проводится это исследование.
Контакты исследования
- Имя: Xunming Ji
- Номер телефона: 01083198962
- Электронная почта: jixm@ccmu.edu.cn
Учебное резервное копирование контактов
- Имя: Chuanjie Wu
- Номер телефона: 01083199439
- Электронная почта: wuchuanjie@ccmu.edu.cn
Места учебы
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Beijing Municipality
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Beijing, Beijing Municipality, Китай, 100053
- Xuanwu Hospital, Capital Medical University
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Контакт:
- Chuanjie Wu
- Номер телефона: 010-83199439
- Электронная почта: wuchuanjie@ccmu.edu.cn
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Критерии участия
Исследователи ищут людей, которые соответствуют определенному описанию, называемому критериям приемлемости. Некоторыми примерами этих критериев являются общее состояние здоровья человека или предшествующее лечение.
Критерии приемлемости
Возраст, подходящий для обучения
- Взрослый
- Пожилой взрослый
Принимает здоровых добровольцев
Да
Описание
Inclusion Criteria:
- Age 18 years or greater, male or female;
- Completed primary school or higher education;
- Able to use a smartphone or computer to complete online interaction;
- No history of acute ischemic stroke, systemic lupus erythematosus, gastric ulcer, pneumonia, acute cardiac infarction, urinary tract infection, uterine fibroids, diabetes, osteoarthritis, or migraine.
- Able to understand and comply with study procedures and to provide written informed consent.
Exclusion Criteria:
- Currently or previously employed as a healthcare worker;
- Previously received systematic medical training;
- Currently involved in concurrent research that may interfere with the results of the present trial;
- The investigator considered that the participant had other conditions that might affect compliance or preclude participation.
Учебный план
В этом разделе представлена подробная информация о плане исследования, в том числе о том, как планируется исследование и что оно измеряет.
Как устроено исследование?
Детали дизайна
- Основная цель: Исследования в области здравоохранения
- Распределение: Рандомизированный
- Интервенционная модель: Параллельное назначение
- Маскировка: Одинокий
Оружие и интервенции
Группа участников / Армия |
Вмешательство/лечение |
|---|---|
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Экспериментальный: 3M-6D education GPT Group
Participants will first be trained in 3M-6D education, then use ChatGPT to complete a consultation task in unrestricted natural language in approximately 10 minutes.
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3M-6D education is designed based on Cognitive Load Theory to reduce the cognitive burden on patients during medical interactions with AI and to improve the clarity and completeness of symptom reporting. Guided by cognitive load theory and the natural process physicians use to take medical histories, we identified candidate information dimensions and developed a structured expression framework with six dimensions for public health queries through a Delphi expert consensus process. Participants were instructed to use the framework to describe their symptoms across these six dimensions; this process can typically be completed within three minutes, so we call this approach three minutes six dimensions education (3M-6D education).
Participants use ChatGPT to complete a standardized simulated clinical scenarios in unrestricted natural language.
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Экспериментальный: 3M-6D education Gemini Group
Participants will first be trained in 3M-6D education, then use Gemini to complete a consultation task in unrestricted natural language in approximately 10 minutes.
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3M-6D education is designed based on Cognitive Load Theory to reduce the cognitive burden on patients during medical interactions with AI and to improve the clarity and completeness of symptom reporting. Guided by cognitive load theory and the natural process physicians use to take medical histories, we identified candidate information dimensions and developed a structured expression framework with six dimensions for public health queries through a Delphi expert consensus process. Participants were instructed to use the framework to describe their symptoms across these six dimensions; this process can typically be completed within three minutes, so we call this approach three minutes six dimensions education (3M-6D education).
Participants use Gemini to complete a standardized simulated clinical scenarios in unrestricted natural language.
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Активный компаратор: GPT Group
Participants will use ChatGPT to complete a consultation task in unrestricted natural language in approximately 10 minutes.
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Participants use ChatGPT to complete a standardized simulated clinical scenarios in unrestricted natural language.
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Активный компаратор: Gemini Group
Participants will use Gemini to complete a consultation task in unrestricted natural language in approximately 10 minutes.
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Participants use Gemini to complete a standardized simulated clinical scenarios in unrestricted natural language.
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Без вмешательства: Control group
Participants will use non-AI tools such as internet searches and medical websites to complete a consultation task in unrestricted natural language in approximately 10 minutes.
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Что измеряет исследование?
Первичные показатели результатов
Мера результата |
Мера Описание |
Временное ограничение |
|---|---|---|
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Relevant conditions identification of the 3M-6D education GPT group compared with the GPT group
Временное ограничение: Usually within 1 hour.
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Relevant conditions identification is defined as the proportion of participants whose final response includes the expert-defined final diagnosis or a relevant differential diagnosis.
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Usually within 1 hour.
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Disposition concordance of the 3M-6D education GPT group compared with the GPT group
Временное ограничение: Usually within 1 hour.
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Disposition concordance is defined as the proportion of participants whose final care recommendation matches the expert-defined level.
The five levels are self-care, routine outpatient care, urgent outpatient care, emergency department visit, and emergency medical services.
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Usually within 1 hour.
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Relevant conditions identification of the 3M-6D education Gemini group compared with the Gemini group
Временное ограничение: Usually within 1 hour.
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Usually within 1 hour.
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Disposition concordance of the 3M-6D education Gemini group compared with the Gemini group
Временное ограничение: Usually within 1 hour.
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Usually within 1 hour.
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Вторичные показатели результатов
Мера результата |
Мера Описание |
Временное ограничение |
|---|---|---|
|
Relevant conditions identification of the 3M-6D education GPT group compared with the control group
Временное ограничение: Usually within 1 hour.
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Usually within 1 hour.
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Relevant conditions identification of the 3M-6D education Gemini group compared with the control group
Временное ограничение: Usually within 1 hour.
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Usually within 1 hour.
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Disposition concordance of the 3M-6D education GPT group compared with the control group
Временное ограничение: Usually within 1 hour.
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Usually within 1 hour.
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Disposition concordance of the 3M-6D education Gemini group compared with the control group
Временное ограничение: Usually within 1 hour.
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Usually within 1 hour.
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Red-flag identification in the 3M-6D education GPT group compared with the GPT group
Временное ограничение: Usually within 1 hour.
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Red-flag identification is defined as the proportion of participants whose final response includes the key warning signs that experts defined for the assigned scenario.
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Usually within 1 hour.
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Red-flag identification in the 3M-6D education GPT group compared with the control group
Временное ограничение: Usually within 1 hour.
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Usually within 1 hour.
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Red-flag identification in the 3M-6D education Gemini group compared with the Gemini group
Временное ограничение: Usually within 1 hour.
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Usually within 1 hour.
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Red-flag identification in the 3M-6D education Gemini group compared with the control group
Временное ограничение: Usually within 1 hour.
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Usually within 1 hour.
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NASA Task Load Index score of the 3M-6D education GPT group compared with the GPT group
Временное ограничение: Usually within 1 hour.
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NASA-TLX score is a self-reported task-load score measured after the simulated consultation with a physician.
It includes six domains: mental demand, physical demand, temporal demand, effort, frustration, and performance.
Each domain is scored from 0 to 100.
The total score is the mean of the six domains.
Higher scores indicate greater perceived task load.
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Usually within 1 hour.
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NASA Task Load Index score of the 3M-6D education GPT group compared with the control group
Временное ограничение: Usually within 1 hour.
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Usually within 1 hour.
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NASA Task Load Index score of the 3M-6D education Gemini group compared with the Gemini group
Временное ограничение: Usually within 1 hour.
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Usually within 1 hour.
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NASA Task Load Index score of the 3M-6D education Gemini group compared with the control group
Временное ограничение: Usually within 1 hour.
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Usually within 1 hour.
|
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Relevant conditions identification of the 3M-6D education GPT group compared with the 3M-6D education Gemini group
Временное ограничение: Usually within 1 hour.
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Usually within 1 hour.
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Disposition concordance of the 3M-6D education GPT group compared with the 3M-6D education Gemini group
Временное ограничение: Usually within 1 hour.
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Usually within 1 hour.
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Red-flag identification in the 3M-6D education GPT group compared with the 3M-6D education Gemini group
Временное ограничение: Usually within 1 hour.
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Usually within 1 hour.
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NASA Task Load Index score of the 3M-6D education GPT group compared with the 3M-6D education Gemini group
Временное ограничение: Usually within 1 hour.
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Usually within 1 hour.
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Другие показатели результатов
Мера результата |
Мера Описание |
Временное ограничение |
|---|---|---|
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Failure to identify red flags in the 3M-6D education GPT group compared with the GPT group
Временное ограничение: Usually within 1 hour.
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Failure to identify red flags is defined as the proportion of participants whose final response does not include the expert-defined red-flag symptoms or warning signs for the assigned standardized simulated clinical scenario.
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Usually within 1 hour.
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Failure to identify red flags in the 3M-6D education GPT group compared with the control group
Временное ограничение: Usually within 1 hour.
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Usually within 1 hour.
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Failure to identify red flags in the 3M-6D education Gemini group compared with the Gemini group
Временное ограничение: Usually within 1 hour.
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Usually within 1 hour.
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Failure to identify red flags in the 3M-6D education Gemini group compared with the control group
Временное ограничение: Usually within 1 hour.
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Usually within 1 hour.
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Underestimation of disposition in the 3M-6D education GPT group compared with the GPT group
Временное ограничение: Usually within 1 hour.
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Underestimation of disposition is defined as the proportion of participants whose final care recommendation is lower than the expert-defined disposition level for the assigned standardized simulated clinical scenario.
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Usually within 1 hour.
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Underestimation of disposition in the 3M-6D education GPT group compared with the control group
Временное ограничение: Usually within 1 hour.
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Usually within 1 hour.
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Underestimation of disposition in the 3M-6D education Gemini group compared with the Gemini group
Временное ограничение: Usually within 1 hour.
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Usually within 1 hour.
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Underestimation of disposition in the 3M-6D education Gemini group compared with the control group
Временное ограничение: Usually within 1 hour.
|
Usually within 1 hour.
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Соавторы и исследователи
Здесь вы найдете людей и организации, участвующие в этом исследовании.
Спонсор
Соавторы
Даты записи исследования
Эти даты отслеживают ход отправки отчетов об исследованиях и сводных результатов на сайт ClinicalTrials.gov. Записи исследований и сообщаемые результаты проверяются Национальной медицинской библиотекой (NLM), чтобы убедиться, что они соответствуют определенным стандартам контроля качества, прежде чем публиковать их на общедоступном веб-сайте.
Изучение основных дат
Начало исследования (Оцененный)
20 июня 2026 г.
Первичное завершение (Оцененный)
20 июля 2026 г.
Завершение исследования (Оцененный)
20 июля 2026 г.
Даты регистрации исследования
Первый отправленный
11 июня 2026 г.
Впервые представлено, что соответствует критериям контроля качества
11 июня 2026 г.
Первый опубликованный (Действительный)
16 июня 2026 г.
Обновления учебных записей
Последнее опубликованное обновление (Действительный)
16 июня 2026 г.
Последнее отправленное обновление, отвечающее критериям контроля качества
11 июня 2026 г.
Последняя проверка
1 июня 2026 г.
Дополнительная информация
Термины, связанные с этим исследованием
Ключевые слова
Другие идентификационные номера исследования
- LAMP-1
Планирование данных отдельных участников (IPD)
Планируете делиться данными об отдельных участниках (IPD)?
НЕ РЕШЕНО
Информация о лекарствах и устройствах, исследовательские документы
Изучает лекарственный продукт, регулируемый FDA США.
Нет
Изучает продукт устройства, регулируемый Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов США.
Нет
Эта информация была получена непосредственно с веб-сайта clinicaltrials.gov без каких-либо изменений. Если у вас есть запросы на изменение, удаление или обновление сведений об исследовании, обращайтесь по адресу register@clinicaltrials.gov. Как только изменение будет реализовано на clinicaltrials.gov, оно будет автоматически обновлено и на нашем веб-сайте. .