Denne siden ble automatisk oversatt og nøyaktigheten av oversettelsen er ikke garantert. Vennligst referer til engelsk versjon for en kildetekst.

Improving the Reliability of LLMs as Medical Assistants for the General Public (LAMP-1)

11. juni 2026 oppdatert av: Ji Xunming,MD,PhD, Capital Medical University

Improving the Reliability of LLMs as Medical Assistants for the General Public: a Proof of Concept Simulation Trial

This study will evaluate whether three-minute six-dimensions education(3M-6D education) can improve the reliability of large language models as medical assistants for the general public. Participants will be randomly assigned to receive or not receive 3M-6D education and then use ChatGPT, Gemini, or non-AI information resources. The study will assess relevant condition identification, disposition concordance, red-flag identification, and NASA-TLX score.

Studieoversikt

Status

Har ikke rekruttert ennå

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

This randomized, controlled, proof-of-concept simulation trial will evaluate whether three-minute six-dimensions education (3M-6D education) can improve the reliability of large language models as medical assistants for the general public.

Eligible participants will be randomly assigned in a 1:1:1:1:1 ratio to one of five study groups: the 3M-6D education GPT group, the GPT group, the 3M-6D education Gemini group, the Gemini group, or the control group. Participants in the 3M-6D education GPT and 3M-6D education Gemini groups will receive approximately three minutes of education before using ChatGPT or Gemini.Each participant will be randomly assigned one of 10 standardized clinical scenarios and complete a simulated counseling task in unrestricted natural language within approximately 10 minutes. The study will assess relevant condition identification, disposition concordance, red-flag identification, and NASA-TLX score.

Studietype

Intervensjonell

Registrering (Antatt)

525

Fase

  • Ikke aktuelt

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiekontakt

Studer Kontakt Backup

Studiesteder

  • Kina
    • Beijing Municipality
      • Beijing, Beijing Municipality, Kina, 100053
        • Xuanwu Hospital, Capital Medical University
        • Ta kontakt med:

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

  • Voksen
  • Eldre voksen

Tar imot friske frivillige

Ja

Beskrivelse

Inclusion Criteria:

  1. Age 18 years or greater, male or female;
  2. Completed primary school or higher education;
  3. Able to use a smartphone or computer to complete online interaction;
  4. No history of acute ischemic stroke, systemic lupus erythematosus, gastric ulcer, pneumonia, acute cardiac infarction, urinary tract infection, uterine fibroids, diabetes, osteoarthritis, or migraine.
  5. Able to understand and comply with study procedures and to provide written informed consent.

Exclusion Criteria:

  1. Currently or previously employed as a healthcare worker;
  2. Previously received systematic medical training;
  3. Currently involved in concurrent research that may interfere with the results of the present trial;
  4. The investigator considered that the participant had other conditions that might affect compliance or preclude participation.

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

  • Primært formål: Helsetjenesteforskning
  • Tildeling: Randomisert
  • Intervensjonsmodell: Parallell tildeling
  • Masking: Enkelt

Våpen og intervensjoner

Deltakergruppe / Arm
Intervensjon / Behandling
Eksperimentell: 3M-6D education GPT Group
Participants will first be trained in 3M-6D education, then use ChatGPT to complete a consultation task in unrestricted natural language in approximately 10 minutes.
Atferdsmessig: three minutes six dimensions education

3M-6D education is designed based on Cognitive Load Theory to reduce the cognitive burden on patients during medical interactions with AI and to improve the clarity and completeness of symptom reporting.

Guided by cognitive load theory and the natural process physicians use to take medical histories, we identified candidate information dimensions and developed a structured expression framework with six dimensions for public health queries through a Delphi expert consensus process. Participants were instructed to use the framework to describe their symptoms across these six dimensions; this process can typically be completed within three minutes, so we call this approach three minutes six dimensions education (3M-6D education).

Annen: ChatGPT
Participants use ChatGPT to complete a standardized simulated clinical scenarios in unrestricted natural language.
Eksperimentell: 3M-6D education Gemini Group
Participants will first be trained in 3M-6D education, then use Gemini to complete a consultation task in unrestricted natural language in approximately 10 minutes.
Atferdsmessig: three minutes six dimensions education

3M-6D education is designed based on Cognitive Load Theory to reduce the cognitive burden on patients during medical interactions with AI and to improve the clarity and completeness of symptom reporting.

Guided by cognitive load theory and the natural process physicians use to take medical histories, we identified candidate information dimensions and developed a structured expression framework with six dimensions for public health queries through a Delphi expert consensus process. Participants were instructed to use the framework to describe their symptoms across these six dimensions; this process can typically be completed within three minutes, so we call this approach three minutes six dimensions education (3M-6D education).

Annen: Gemini
Participants use Gemini to complete a standardized simulated clinical scenarios in unrestricted natural language.
Aktiv komparator: GPT Group
Participants will use ChatGPT to complete a consultation task in unrestricted natural language in approximately 10 minutes.
Annen: ChatGPT
Participants use ChatGPT to complete a standardized simulated clinical scenarios in unrestricted natural language.
Aktiv komparator: Gemini Group
Participants will use Gemini to complete a consultation task in unrestricted natural language in approximately 10 minutes.
Annen: Gemini
Participants use Gemini to complete a standardized simulated clinical scenarios in unrestricted natural language.
Ingen inngripen: Control group
Participants will use non-AI tools such as internet searches and medical websites to complete a consultation task in unrestricted natural language in approximately 10 minutes.

Hva måler studien?

Primære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Relevant conditions identification of the 3M-6D education GPT group compared with the GPT group
Tidsramme: Usually within 1 hour.
Relevant conditions identification is defined as the proportion of participants whose final response includes the expert-defined final diagnosis or a relevant differential diagnosis.
Usually within 1 hour.
Disposition concordance of the 3M-6D education GPT group compared with the GPT group
Tidsramme: Usually within 1 hour.
Disposition concordance is defined as the proportion of participants whose final care recommendation matches the expert-defined level. The five levels are self-care, routine outpatient care, urgent outpatient care, emergency department visit, and emergency medical services.
Usually within 1 hour.
Relevant conditions identification of the 3M-6D education Gemini group compared with the Gemini group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Disposition concordance of the 3M-6D education Gemini group compared with the Gemini group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.

Sekundære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Relevant conditions identification of the 3M-6D education GPT group compared with the control group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Relevant conditions identification of the 3M-6D education Gemini group compared with the control group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Disposition concordance of the 3M-6D education GPT group compared with the control group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Disposition concordance of the 3M-6D education Gemini group compared with the control group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Red-flag identification in the 3M-6D education GPT group compared with the GPT group
Tidsramme: Usually within 1 hour.
Red-flag identification is defined as the proportion of participants whose final response includes the key warning signs that experts defined for the assigned scenario.
Usually within 1 hour.
Red-flag identification in the 3M-6D education GPT group compared with the control group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Red-flag identification in the 3M-6D education Gemini group compared with the Gemini group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Red-flag identification in the 3M-6D education Gemini group compared with the control group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
NASA Task Load Index score of the 3M-6D education GPT group compared with the GPT group
Tidsramme: Usually within 1 hour.
NASA-TLX score is a self-reported task-load score measured after the simulated consultation with a physician. It includes six domains: mental demand, physical demand, temporal demand, effort, frustration, and performance. Each domain is scored from 0 to 100. The total score is the mean of the six domains. Higher scores indicate greater perceived task load.
Usually within 1 hour.
NASA Task Load Index score of the 3M-6D education GPT group compared with the control group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
NASA Task Load Index score of the 3M-6D education Gemini group compared with the Gemini group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
NASA Task Load Index score of the 3M-6D education Gemini group compared with the control group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Relevant conditions identification of the 3M-6D education GPT group compared with the 3M-6D education Gemini group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Disposition concordance of the 3M-6D education GPT group compared with the 3M-6D education Gemini group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Red-flag identification in the 3M-6D education GPT group compared with the 3M-6D education Gemini group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
NASA Task Load Index score of the 3M-6D education GPT group compared with the 3M-6D education Gemini group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.

Andre resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Failure to identify red flags in the 3M-6D education GPT group compared with the GPT group
Tidsramme: Usually within 1 hour.
Failure to identify red flags is defined as the proportion of participants whose final response does not include the expert-defined red-flag symptoms or warning signs for the assigned standardized simulated clinical scenario.
Usually within 1 hour.
Failure to identify red flags in the 3M-6D education GPT group compared with the control group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Failure to identify red flags in the 3M-6D education Gemini group compared with the Gemini group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Failure to identify red flags in the 3M-6D education Gemini group compared with the control group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Underestimation of disposition in the 3M-6D education GPT group compared with the GPT group
Tidsramme: Usually within 1 hour.
Underestimation of disposition is defined as the proportion of participants whose final care recommendation is lower than the expert-defined disposition level for the assigned standardized simulated clinical scenario.
Usually within 1 hour.
Underestimation of disposition in the 3M-6D education GPT group compared with the control group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Underestimation of disposition in the 3M-6D education Gemini group compared with the Gemini group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.
Underestimation of disposition in the 3M-6D education Gemini group compared with the control group
Tidsramme: Usually within 1 hour.
Usually within 1 hour.

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

Capital Medical University

Samarbeidspartnere

Xuanwu Hospital, Beijing

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Antatt)

20. juni 2026

Primær fullføring (Antatt)

20. juli 2026

Studiet fullført (Antatt)

20. juli 2026

Datoer for studieregistrering

Først innsendt

11. juni 2026

Først innsendt som oppfylte QC-kriteriene

11. juni 2026

Først lagt ut (Faktiske)

16. juni 2026

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

16. juni 2026

Siste oppdatering sendt inn som oppfylte QC-kriteriene

11. juni 2026

Sist bekreftet

1. juni 2026

Mer informasjon

Begreper knyttet til denne studien

Nøkkelord

Andre studie-ID-numre

  • LAMP-1

Plan for individuelle deltakerdata (IPD)

Planlegger du å dele individuelle deltakerdata (IPD)?

UBESLUTTE

Legemiddel- og utstyrsinformasjon, studiedokumenter

Studerer et amerikansk FDA-regulert medikamentprodukt

Nei

Studerer et amerikansk FDA-regulert enhetsprodukt

Nei

Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .

Kliniske studier på Relevant Conditions Identification

Søk i lignende forsøk

Sponsorer og samarbeidspartnere

Medisinsk tilstand

Legemiddelintervensjoner

CROs by country

CROs in Guatemala

Forhold

Sjeldne sykdommer

Legemiddelintervensjoner

Kosttilskudd

Sponsor / samarbeidspartnere

Steder

Abonnere