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Sympathetic Nerve Activity and Strength Gains in Resistance Versus Concurrent Training (SKNA-CT)

25. juni 2026 opdateret af: Beijing Sport University

Sympathetic Activation and Strength Gains Rise Together Under Resistance Training But Uncouple Under Concurrent Training: An 8-Week Randomized Controlled Trial in Untrained Men

This study examines how the body's stress (sympathetic) nervous system responds to 8 weeks of either strength training alone or strength training combined with endurance (treadmill running) training in previously untrained young men. Skin sympathetic nerve activity, a noninvasive marker of sympathetic nervous system activity, is measured before and after training, along with muscle strength, jumping ability, and heart rate variability. The study investigates whether changes in sympathetic nervous system activity are associated with changes in strength and jumping ability, and whether this relationship differs between men who perform strength training alone versus those who combine strength and endurance training.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

This study examined how the body's stress (sympathetic) nervous system responds to 8 weeks of either strength training alone or strength training combined with endurance (treadmill running) training in previously untrained young men. Skin sympathetic nerve activity, a noninvasive marker of sympathetic nervous system activity, was measured before and after training, along with muscle strength, jumping ability, and heart rate variability. The study found that in men who did strength training only, those whose sympathetic nervous system activity increased the most also gained the most strength and jumping ability. This relationship was not seen, and in some cases reversed, in men who combined strength training with endurance training. The findings suggest that adding endurance exercise changes how the nervous system adapts to a strength training program, alongside the well-documented reduction in strength gains seen with combined training (the "interference effect").

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

30

Fase

  • Ikke anvendelig

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Kina
      • Beijing, Kina, 100091
        • Beijing sport University

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Voksen

Tager imod sunde frivillige

Ja

Beskrivelse

Inclusion Criteria:

  • Healthy young men
  • No hypertension or cardiovascular/vascular disease
  • No migraine or neurodegenerative disease
  • No smoking or alcohol use
  • No prior structured exercise training
  • No musculoskeletal injury
  • Willing to abstain from caffeine, alcohol, and strenuous exercise for 24 hours before testing

Exclusion Criteria:

  • Hypertension or cardiovascular/vascular disease
  • Migraine or neurodegenerative disease
  • Current smoking or alcohol use
  • Prior structured exercise training history
  • Musculoskeletal injury precluding resistance or endurance exercise

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Grundvidenskab
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Dobbelt

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Aktiv komparator: Strength-only training
Participants performed a supervised resistance training program three times weekly for 8 weeks: weighted calf raises (80% 1RM, 4x6), back squats (75% 1RM, 4x6), countermovement jumps (60-cm target height, 4x6), and weighted lunges (60% 1RM, 4x5), using a Smith machine.
Andet: Strength-only training
Supervised resistance exercise comprising weighted calf raises, back squats, countermovement jumps, and weighted lunges, performed on a Smith machine three times weekly for 8 weeks.
Eksperimentel: Concurrent training
Participants performed the identical resistance training program as the Strength-only arm, followed by 30-40 minutes of moderate-intensity treadmill running (46-64% VO2max) once heart rate had returned to 40% of maximum, three times weekly for 8 weeks (a strength-priority exercise sequence).
Andet: Concurrent training
performed on a Smith machine three times weekly for 8 weeks.

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
skin sympathetic nerve activity (aSKNA)
Tidsramme: Baseline and 8 weeks
Average rectified voltage of skin sympathetic nerve activity recorded noninvasively via the neuECG method.
Baseline and 8 weeks
Change in one-repetition maximum (1RM) back squat
Tidsramme: Baseline and 8 weeks
Baseline and 8 weeks
Change in countermovement jump (CMJ) height
Tidsramme: Baseline and 8 weeks
Baseline and 8 weeks

Sekundære resultatmål

Resultatmål
Tidsramme
Change in CMJ peak velocity
Tidsramme: Baseline and 8 weeks
Baseline and 8 weeks
Change in CMJ peak power
Tidsramme: Baseline and 8 weeks
Baseline and 8 weeks
Change in SKNA burst duration
Tidsramme: Baseline and 8 weeks
Baseline and 8 weeks
Change in SKNA burst amplitude
Tidsramme: Baseline and 8 weeks
Baseline and 8 weeks
Change in SKNA burst total area
Tidsramme: Baseline and 8 weeks
Baseline and 8 weeks
Change in CMJ peak force
Tidsramme: Baseline and 8 weeks
Baseline and 8 weeks

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Beijing Sport University

Samarbejdspartnere

China institute of sport science

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

1. august 2024

Primær færdiggørelse (Faktiske)

12. december 2024

Studieafslutning (Faktiske)

13. december 2024

Datoer for studieregistrering

Først indsendt

22. juni 2026

Først indsendt, der opfyldte QC-kriterier

25. juni 2026

Først opslået (Faktiske)

2. juli 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

2. juli 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

25. juni 2026

Sidst verificeret

1. september 2024

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Andre undersøgelses-id-numre

  • BSU-2024224H

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

JA

IPD-planbeskrivelse

Individual participant data that underlie the results reported in this article will be made available upon reasonable request to the corresponding author.

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

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Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Sympatisk nervesystem

Kliniske forsøg med Strength-only training

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