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MRI Study of Self-Perception of Postural Stability

3. März 2008 aktualisiert von: National Institute of Neurological Disorders and Stroke (NINDS)

Self-Perception of Postural Stability: Event-Related fMRI Study

This study will use functional magnetic resonance imaging (MRI) to examine loss of balance in the elderly. Falls due to balance problems are a major health issue in older people, often resulting in bone fractures and other bodily injuries, and in functional decline. Risk factors for falling in the elderly include some standing positions in which older people usually experience balance problems, such as leaning forwards or backwards. Functional MRI records brain function while the subject performs a task, such as moving a limb or speaking, and detects changes in the brain regions involved in those tasks. This study will look at different brain areas to see which areas might control what people see around them while they are standing.

Healthy normal volunteers between 20 and 90 years of age may be eligible for this study. Candidates must be in good health, have no difficulties in performing activities of daily living, and be able to walk for at least 400 meters (1/4 mile). They will be screened with a medical history and physical examination.

Participants will undergo functional MRI while performing visual recognition tasks in two experiments, described below. For the MRI procedure, the subject lies in the MRI scanner, a narrow metal cylinder containing a strong magnet, for 20 minutes to 3 hours, with most scans lasting between 45 and 90 minutes. The experiments are as follows:

Experiment 1

During MRI scanning, the subject watches computer-generated movies of a person leaning forwards and backwards. When the subject recognizes an unstable body position in the movements, he or she presses a computer mouse.

Experiment 2

During MRI scanning, the subject watches still pictures of people leaning in stable and unstable postures and presses a button as soon as he or she recognizes that the posture is unstable.

Studienübersicht

Status

Abgeschlossen

Bedingungen

Detaillierte Beschreibung

A number of studies have explored the role of visual, vestibular and somatosensory systems in the control of upright posture. However, the cortical control of postural stability, in general, and the role of higher cognitive function in assessment of postural stability, in specific, has not been studied extensively. It is well established that certain features of postural control change during the advancing years of life so that the stability of posture can be a problem in the elderly. However, neural mechanisms of postural stability that decline with age and make older adults more prone to falling have not been identified specifically. To characterize specific causes of falling in the elderly is problematic, because human posture is a product of an extremely complex dynamical system and like any other physical activity undergoes dramatic changes in organization throughout the life-span. In our previous research we showed the neural activation patterns embodied in the electroencephalogram (EEG) were associated with recognition of unstable postures in young healthy subjects. In another protocol, we propose that these patterns will systematically change with aging, and will result in difficulty to discriminate relevant from irrelevant information in the control of upright posture. The present study focuses on the evaluation of neural activation patterns underlying recognition of unstable postures in 15 young controls and 15 elderly subjects using both the block and event-related functional MRI (fMRI) designs. We will first analyze how the frontal-parieto-occipital circuits play a role in perception of postural stability in young subjects and then perform similar studies using elderly subjects. After the fMRI measurements a detailed evaluation of the haemodynamic response (BOLD) signals will be performed. Further analysis will look at the functional connectivity between the motion-selective cortical area (V5), the posterior parietal cortex (PP) and the frontal cortex (FC), using correlation methods. It is expected that from the study will uncover important insights in neural mechanisms as it relates to the self-perception of postural stability and its deterioration as a result of aging.

Studientyp

Beobachtungs

Einschreibung

40

Kontakte und Standorte

Dieser Abschnitt enthält die Kontaktdaten derjenigen, die die Studie durchführen, und Informationen darüber, wo diese Studie durchgeführt wird.

Studienorte

  • Vereinigte Staaten
    • Maryland
      • Bethesda, Maryland, Vereinigte Staaten, 20892
        • National Institute of Neurological Disorders and Stroke (NINDS)

Teilnahmekriterien

Forscher suchen nach Personen, die einer bestimmten Beschreibung entsprechen, die als Auswahlkriterien bezeichnet werden. Einige Beispiele für diese Kriterien sind der allgemeine Gesundheitszustand einer Person oder frühere Behandlungen.

Zulassungskriterien

Studienberechtigtes Alter

  • Kind
  • Erwachsene
  • Älterer Erwachsener

Akzeptiert gesunde Freiwillige

Nein

Studienberechtigte Geschlechter

Alle

Beschreibung

INCLUSION CRITERIA:

There will be 20 subjects in each aforementioned age group.

Subjects will be enrolled in this study if they are within the range of 20-50 (young group) and 70-90 (old group) years old, in good health, report no difficulties or need for help in performing self-care or instrumental activities of daily living, are able to walk for at least 400 meters.

All subjects and patients participating in this study will have a valid Clinical Center Medical Record Number.

EXCLUSION CRITERIA:

We will be unable to study people who have substantial cognitive impairment based on mental status screening tests, history of cardiovascular disease (including angina, myocardial infarction, congestive heart failure, cerebro-vascular disease), cancer, neurological diseases, birth defects, kidney or liver disease, gastrointestinal (G.I.) disease, musculo-skeletal disorder (if they cause pathological weakness and/or chronic pain), important sensory deficits and any conditions that precludes them from being tested with standard neuropsychological tests.

MRI experiments will not be performed in subjects or patients who have pacemakers, brain stimulators, dental implants or metallic braces, aneurysm clips (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and cochlear implants), permanent eyeliner, insulin pump, or shrapnel fragments.

We will not scan pregnant women because of the safety of high magnetic fields to the fetus is not established.

Studienplan

Dieser Abschnitt enthält Einzelheiten zum Studienplan, einschließlich des Studiendesigns und der Messung der Studieninhalte.

Wie ist die Studie aufgebaut?

Mitarbeiter und Ermittler

Hier finden Sie Personen und Organisationen, die an dieser Studie beteiligt sind.

Sponsor

National Institute of Neurological Disorders and Stroke (NINDS)

Publikationen und hilfreiche Links

Die Bereitstellung dieser Publikationen erfolgt freiwillig durch die für die Eingabe von Informationen über die Studie verantwortliche Person. Diese können sich auf alles beziehen, was mit dem Studium zu tun hat.

Allgemeine Veröffentlichungen

Studienaufzeichnungsdaten

Diese Daten verfolgen den Fortschritt der Übermittlung von Studienaufzeichnungen und zusammenfassenden Ergebnissen an ClinicalTrials.gov. Studienaufzeichnungen und gemeldete Ergebnisse werden von der National Library of Medicine (NLM) überprüft, um sicherzustellen, dass sie bestimmten Qualitätskontrollstandards entsprechen, bevor sie auf der öffentlichen Website veröffentlicht werden.

Haupttermine studieren

Studienbeginn

1. Mai 2003

Studienabschluss

1. Mai 2005

Studienanmeldedaten

Zuerst eingereicht

7. Mai 2003

Zuerst eingereicht, das die QC-Kriterien erfüllt hat

7. Mai 2003

Zuerst gepostet (Schätzen)

8. Mai 2003

Studienaufzeichnungsaktualisierungen

Letztes Update gepostet (Schätzen)

4. März 2008

Letztes eingereichtes Update, das die QC-Kriterien erfüllt

3. März 2008

Zuletzt verifiziert

1. Mai 2005

Mehr Informationen

Begriffe im Zusammenhang mit dieser Studie

Schlüsselwörter

Andere Studien-ID-Nummern

  • 030183
  • 03-N-0183

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