Oxaliplatin in Combination With Capecitabine and Concurrent Radiation Therapy in Non-Small Cell Lung Cancer

Inclusion Criteria:

• histologically proven non-small cell lung cancer
• inoperable Stage III A or B NSCLC
• must have measurable disease by RECIST criteria
• no more than one prior chemotherapy for advanced disease
• ECOG Performance Status of 0, 1, or 2
• must be able to swallow pills or have a working gastric feeding tube and no evidence of malabsorption
• negative serum beta-HCG test and under active contraception (for females of childbearing potential)
• no known allergies to any of the study drugs
• willingness to sign an informed consent

Exclusion Criteria:

• women who are pregnant or breastfeeding
• ANC of less than 1500/mm3
• platelet count of less than 100,000/mm3
• estimated creatinine clearance of less than 50 cc/min (as measured by the Cockcroft-Gault equation)
• bilirubin of less than 2mg/dl
• SGPT of greater than 2x nl
• peripheral neuropathy of Grade 2 or higher
• more than one previous chemotherapy and previous radiation therapy to the chest
• a history of CHF/MI or other significant cardiac history within the last six months