Improving Sleep Continuity Through Mindfulness Training for Better Cognitive Ageing. (MIST)
Descripción general del estudio
Estado
Intervención / Tratamiento
Descripción detallada
Cognitive decline in the elderly is a rapidly growing concern in Singapore and other developed Asian nations. Among the major but understudied factors that may exacerbate this decline is poor sleep quality. Targeting sleep to decelerate or even reverse age-related cognitive decline may represent a low-cost, high-return solution to a widespread societal problem.
To accomplish this goal, the investigators propose to test mindfulness-based training (MBT) as an intervention to improve sleep quality and cognition.
In this pilot grant, the investigators will study a group of participants (N = 120) in a randomized controlled design pitting MBT (N =60) against sleep hygiene education (SHEEP, N = 60).
Hypothesis 1: MBT will lead to significantly greater improvements in sustained and executive attention relative to SHEEP (measured both behaviorally and using functional magnetic resonance imaging).
Hypothesis 2: Cognitive outcomes will be mediated by improvements in subjective and objective sleep quality.
Good sleep is critical for cognition at all ages, and especially in the elderly
Adequate sleep is important for optimal cognitive function across the lifespan. Although the association between sleep and cognitive function is bi-directional, alterations in sleep frequently occur prior to the appearance of cognitive symptoms in Alzheimer's Disease (AD). Almost 50% of older adults report at least one sleep problem, and there is growing evidence that sleep complaints and disturbances might have negative effects on cognition.
Retired older adults have the freedom to sleep ad libitum but this benefit is offset by age-associated changes in sleep such as poorer subjective quality, increased fragmentation and/or altered macrostructure. Although sleep duration is the measure that has received the most attention, there is accumulating evidence that sleep quality (Blackwell et al., 2014) and sleep fragmentation in particular, can have deleterious effects on brain structure and cognition. A change in sleep pattern in late adulthood can foreshadow cognitive decline, perhaps as a result of accumulation of neurotoxic substances that are normally cleared during sleep.
Tipo de estudio
Inscripción (Actual)
Fase
- No aplica
Contactos y Ubicaciones
Ubicaciones de estudio
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Singapore, Singapur, 169608
- Singapore General Hospital
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Criterios de participación
Criterio de elegibilidad
Edades elegibles para estudiar
Acepta Voluntarios Saludables
Géneros elegibles para el estudio
Descripción
Inclusion Criteria:
- Adults aged 50 to 80
- English-speaking
- Mini-Mental State Examination Score ≥ 26
- Montreal Cognitive Assessment Score ≥ 23
At least one of the following sleep difficulties are expressed:
(i) average reported sleep latency of more than 30 minutes
(ii) average wakefulness after sleep onset of more than 30 minutes
(iii) sleep efficiency or total sleep time of less than 6.5 hours
and/or
(iv) also a cut off in the PSQI>/=5
Exclusion Criteria:
- Presence of major neurological conditions such as epilepsy, stroke, Parkinson's Disease and/or brain injury
- Presence of major psychiatric conditions such as major depression or schizophrenia
- Unsuitability for fMRI scanning (e.g. pacemakers, metallic implants, claustrophobia)
- Unable to give independent consent or no consent available
Plan de estudios
¿Cómo está diseñado el estudio?
Detalles de diseño
- Propósito principal: Tratamiento
- Asignación: Aleatorizado
- Modelo Intervencionista: Asignación paralela
- Enmascaramiento: Ninguno (etiqueta abierta)
Armas e Intervenciones
Grupo de participantes/brazo |
Intervención / Tratamiento |
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Experimental: Mindfulness Based Therapy for Insomnia
The mindfulness-based intervention consists of eight 2-hour sessions covering various mindfulness techniques (e.g.
mindfulness of breath, body and movement, senses and informal practice, and empathy and compassion) that pertain to people with sleep problems and insomnia.
Participants will be provided handouts for the information covered during these talks and discussions.
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The mindfulness-based intervention consists of eight 2-hour sessions covering various mindfulness techniques (e.g.
mindfulness of breath, body and movement, senses and informal practice, and empathy and compassion) that pertain to people with sleep problems and insomnia.
Participants will be provided handouts for the information covered during these talks and discussions.
Otros nombres:
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Comparador activo: Sleep Hygiene Education Exercise Program
The Sleep Hygiene Education and Exercise Program has known relationships with good sleep quality.
It will comprise of eight weekly 2-hour sessions.
Each session will introduce a concept related to sleep and sleep hygiene.
The facilitator will provide the theory and rationale behind the concept, and encourage participants to share and discuss their experiences related to the concept.
The session will end with the participants evaluating how to implement the specific concept in their daily lives, and its potential implications for their sleep.
Participants will be provided with a manual that outlines the concept and how they intend to apply it to their daily lives.
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The Sleep Hygiene Education and Exercise Program has known relationships with good sleep quality.
It will comprise 8 weekly 2-hour sessions.
Each session will introduce a concept related to sleep and sleep hygiene.
The facilitator will provide the theory and rationale behind the concept, and encourage participants to share and discuss their experiences related to the concept.
The session will end with the participants evaluating how to implement the specific concept in their daily lives, and its potential implications for their sleep.
Participants will be provided with a manual that outlines the concept and how they intend to apply it to their daily lives.
Otros nombres:
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¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
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Change in Subjective measures of Sleep quality: Pittsburgh Sleep Quality Index Score
Periodo de tiempo: Up to one month
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Pittsburgh Sleep Quality Index Score (PSQI) is a 19-item self-rated questionnaire for evaluating subjective sleep quality over the previous month. The PSQI has a sensitivity of 89.6% and specificity of 86.5% for identifying cases with sleep disorder, using a cut-off score of 5. The first 4 items are open questions, whereas items 5 to 19 are rated on a 4-point Likert scale. Individual items scores yield 7 components. A total score, ranging from 0 to 21, is obtained by adding the 7 component scores. A score of 5 and above suggests poor sleep quality. A decrease in PSQI score following intervention would reflect and improvement of sleep quality. |
Up to one month
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Polysomnography: objective changes in sleep onset latency (SOL)
Periodo de tiempo: One night
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Polysomnography is a multi-parametric test used in the study of sleep and as a diagnostic tool in sleep medicine. PSG is a comprehensive recording of bio-physiological changes that occur during sleep. It will be performed at night, at the convenience of the participants' home. PSG monitors many body functions including brain, eye movements, muscle activity or skeletal muscle activation and heart rhythm during sleep. The investigators will use a Somnimedics PSG kit. Sleep onset latency reflects the amount of time it takes to participants to fall asleep from the moment they go to bed in the evening, so higher SOL are indicative of poor sleep quality. This objective measure of participants sleep onset latency will judge sleep quality against the subjective measures obtained through the sleep questionnaires. |
One night
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Actiwatch: objective changes in sleep onset latency (SOL)
Periodo de tiempo: One week
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Wrist-worn actigraphy is a convenient and reliable way to monitor sleep. It will be performed using research-grade, wrist-worn accelerometers that are calibrated to detect sleep by inferring from movement patterns. The systems used in this proposal (Philips Respironics AW-2 or Spectrum) has been calibrated against PSG. Sleep onset latency reflects the amount of time it takes to participants to fall asleep from the moment they go to bed in the evening, on average over seven nights of recording. This objective measure of participants sleep onset latency will judge sleep quality against the subjective measures obtained through the sleep questionnaires. |
One week
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Polysomnography: objective changes in wake after sleep onset (WASO)
Periodo de tiempo: One night
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In addition to Sleep Onset Latency (Primary outcome 2), a second objective measure of sleep quality is extracted from the polysomnography recording: periods of wakefulness occurring after defined sleep onset. WASO is calculated by taking into account the total time spent in bed, minus sleep latency and minus total sleep time. High WASO scores reflect low sleep continuity and poor sleep quality. This second measure of participants sleep will judge sleep quality against the subjective measures obtained through the sleep questionnaires. |
One night
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Actiwatch: objective changes in wake after sleep onset (WASO)
Periodo de tiempo: One week
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As with measures from PSG, in addition to Sleep Onset Latency (Primary outcome 3), a second objective measure of sleep quality is extracted from the Actiwatch recording: periods of wakefulness occurring after defined sleep onset. WASO is calculated by taking into account the total time spent in bed, minus sleep latency and minus total sleep time, averaged over seven consecutive nights. This second measure of participants sleep will judge sleep quality against the subjective measures obtained through the sleep questionnaires. |
One week
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Change in Subjective measures of Sleep quality: Insomnia Severity Index
Periodo de tiempo: Past two weeks
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Insomnia Severity Index (ISI) evaluates an individual's level of tendency for insomnia on a 7-item questionnaire, scoring in total from 0 to 28.
Scores above 15 indicates moderate severity of clinical insomnia while scores above 22 are indicative of severe clinical insomnia.
ISI internal consistency was excellent for population samples both in the community and clinical samples as well, (Cronbach α of 0.90 and 0.91 respectively).
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Past two weeks
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Change in Cognitive and Attention tasks performance (CANTAB: Reaction time task)
Periodo de tiempo: Up to 10 minutes
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Reaction time task (RTI) provides assays of motor and mental response speeds, as well as measures of movement time, reaction time and response accuracy.
Primary outcome: reaction times.
Lower reaction times are indicative of better performance.
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Up to 10 minutes
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Change in Cognitive and Attention tasks performance (CANTAB: Rapid Visual Information Processing primary outcome)
Periodo de tiempo: Up to 10 minutes
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Rapid Visual Information Processing (RVP) is a sensitive tool for assessment of sustained attention.
Primary outcomes: median response latency.
Lower scores in this measure reflect better sustained attention.
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Up to 10 minutes
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Change in Cognitive and Attention tasks performance (CANTAB: Paired Associate Learning)
Periodo de tiempo: Up to 10 minutes
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Paired Associate Learning (PAL) assesses visual memory and new learning, and is a sensitive tool for accurate assessment of episodic memory.
Primary outcome: accuracy on first trials memory score
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Up to 10 minutes
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Change in Cognitive and Attention tasks performance (CANTAB: Spatial Working Memory)
Periodo de tiempo: Up to 10 minutes
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Spatial Working Memory (SWM) requires retention and manipulation of visuospatial information.
This test has notable executive function demands, and measures strategy use as well as errors.
Primary outcome: number of errors.
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Up to 10 minutes
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Change in Cognitive and Attention tasks performance (CANTAB: Stocking of Cambridge)
Periodo de tiempo: Up to 10 minutes
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Stocking of Cambridge (SOC) assesses spatial planning and requires individuals to use problem-solving strategies to match two sets of stimuli.
Primary outcome: number of problems solved on first choice.
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Up to 10 minutes
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Medidas de resultado secundarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
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Imaging measures (structural): change in orbitofrontal cortex volume
Periodo de tiempo: 6 minutes
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Structural and MRI brain scans will be used to assess the change in the volume of orbitofrontal cortex (OFC) - the key region that is both consistently altered by mindfulness meditation, leading to an increase in volume, and implicated in sleep pathology.
Participants will have their baseline fMRI scan at least 1-week before the start of their participation in the intervention and after the end of the intervention.
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6 minutes
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Change in functional imaging measures: Resting state and Inscape
Periodo de tiempo: 10 minutes
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During two rsfMRI scans, subjects are imaged over several minutes while their eyes are open, but without performing any explicit task. It has been recognized that a person's brain activity at rest contains a rich source of information about their brain function. One of the resting state scan will show only a fixation cross on the screen (resting state), and the second one (Inscape) will show a short video developed in order to minimize the cognitive processing involved while decreasing head movement and sleepiness in the scanner. These data are typically extracted by decomposing the time-varying signal during resting periods into independent, intrinsically connected networks. The investigators propose to use traditional connectivity analysis as well as a newer method: graph theory analysis Measure will be increase of task ready state in Dynamic Functional Connectivity, as previous literature suggested that this is positively linked with mindfulness predisposition. |
10 minutes
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Change in functional imaging measures: Breath counting task
Periodo de tiempo: 10 minutes
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Main measure is change in cortical activity during sustained attention task, before and after intervention. Similar analysis to the resting-state fMRI scans will be conducted to determine the change in Default Mode Network (DMN) and Executive Control Network (ECN) connectivity and anti-correlation between DMN and task-positive networks. |
10 minutes
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Change in functional imaging measures: Letting go practice
Periodo de tiempo: 10 minutes
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Change in cortical connectivity while performing a Letting go practice in the scanner.
Analysis are similar to the resting state and breath counting task (outcomes 13 and 14).
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10 minutes
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Change in Cognitive and Attention tasks performance (CANTAB: Emotion Recognition Task)
Periodo de tiempo: Up to 10 minutes
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Emotion Recognition Task: ERT assesses social cognition and measures the ability of the subject to identify emotions in facial expressions.
Secondary outcomes: Accuracy and Reaction times.
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Up to 10 minutes
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Change in Cognitive and Attention tasks performance (CANTAB: Verbal Recognition Memory)
Periodo de tiempo: Up to 10 minutes
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Verbal Recognition Memory: RM measures the ability to encode and subsequently retrieve verbal information.
Secondary outcomes: number of correct-incorrect responses.
Higher scores are indicative of better verbal recognition memory.
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Up to 10 minutes
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Change in Cognitive and Attention tasks performance (CANTAB: Rapid Visual Information Processing)
Periodo de tiempo: Up to 10 minutes
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Rapid Visual Information Processing: RVP is a sensitive tool for assessment of sustained attention.
Secondary outcomes: A prime.
Higher scores in this measure reflects better performance.
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Up to 10 minutes
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Behavioral Breath counting task: Errors
Periodo de tiempo: 20 minutes
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BCT is a behavioural measure of trait mindfulness found to be reliable and correlated with self-report mindfulness.
Outcome measure: number of errors.
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20 minutes
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Behavioral Breath counting task: Accuracy
Periodo de tiempo: 20 minutes
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BCT is a behavioural measure of trait mindfulness found to be reliable and correlated with self-report mindfulness.
Outcome measure: accuracy and number of miscounts and resets.
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20 minutes
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Pen and Pencil cognitive test: Colour Trails A and B
Periodo de tiempo: Up to 30 minutes
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Widely used instrument in neuropsychological assessment to measure for speed of cognitive processing and executive functioning.
The direct score of both parts A and B are represented by the time taken to complete each task.
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Up to 30 minutes
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Pen and Pencil cognitive test: IQ Advances Progressive Matrices I and II
Periodo de tiempo: Up to 30 minutes
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This test is a nonverbal group test typically used in educational settings.
It is a 60-item test used in measuring abstract reasoning and regarded as a non-verbal estimate of fluid intelligence.
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Up to 30 minutes
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Five Facet Mindfulness Questionnaire (FFMQ)
Periodo de tiempo: Past one month
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This 39-item instrument is based on a factor analytic study of five independently developed mindfulness questionnaires.
The analysis yielded five factors that appear to represent elements of mindfulness as it is currently conceptualized.
The five facets are observing (8 items), describing (8 items), acting with awareness (8 items), non-judging of inner experience (8 items), and non-reactivity to inner experience (7 items).
Scores for each subscales are calculated as the mean of the items, ranging from 1 to 5. Total FFMQ score is the mean of all the subscales, ranging 1-5.
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Past one month
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Change in Subjective measures of Sleep quality: Dysfunctional Beliefs and Attitudes about Sleep
Periodo de tiempo: Past one month
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Dysfunctional Beliefs and Attitudes about Sleep (DBAS) is a 30-item self reported questionnaire to measure people's beliefs and attitudes about their personal sleep situations.
Items are ranked from 0, strongly disagree, to 10, strongly agree.
Total score is mean of all questions, with a higher score representing more dysfunctional beliefs and attitude about sleep.
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Past one month
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Change in Subjective measures of Sleep quality: Pre-Sleep Arousal,
Periodo de tiempo: Past one month
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Pre-Sleep Arousal, PSA is a 16-item self report questionnaire having both cognitive and somatic dimensions of arousal.
Scores on each subscale range from 8-40 (sum of individual answers); high scores on both subscale indicate more arousal.
The Cronbach alpha of this scale was .88 and test-retest reliability is .72.
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Past one month
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Change in Subjective measures about mood, anxiety and quality of life: State Trait Anxiety Inventory
Periodo de tiempo: Past year
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State Trait Anxiety Inventory (STAI) has 40 items, 20 items allocated to each of the State-Anxiety (questions 1-8) and Trait-Anxiety (questions 9-16) subscales, each ranging from 20 to 80.
It is a self-report questionnaires to indicate the presence and severity of current symptoms of anxiety and a generalized propensity to be anxious.
Higher scores are positively correlated with higher levels of anxiety.
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Past year
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Change in Subjective measures about mood, anxiety and quality of life: Beck's Depression Inventory,
Periodo de tiempo: Up to last year
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Beck's Depression Inventory (BDI-II) is a 21- item questionnaire that evaluates the severity of depressive mood states.
Each item is rated between 0 (no symptom impact) and 3 (maximum symptom impact) with a maximum score of 63.
Two domains are evaluated: the cognitive-affective (questions 1-13, ranging from 0 to 39) and somatic domains (questions 14-21, ranging from 0 to 24).
Higher scores in both subscales represent lower mood and more depressive symptoms.
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Up to last year
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Change in Subjective measures about mood, anxiety and quality of life: Short-Form 36
Periodo de tiempo: Up to last year
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Short-Form 36 (SF-36) is a 36-item self-report survey of health, including physical and mental health, with 8 scaled scores, each ranging from a minimum of 0 to max 100. Total score is the mean of all the subscales. Physical functioning : 10 items; Role functioning/physical : 4 items; Role emotional: 3 items; Energy/fatigue: 4 items; Mental Health: 5 items; Social functioning: 2 items; Body pain: 2 items; General health : 5 items; Reported health transition: 1 item. |
Up to last year
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Polysomnography: objective changes in total sleep time (TST)
Periodo de tiempo: One night
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Polysomnography is a multi-parametric test used in the study of sleep and as a diagnostic tool in sleep medicine. It will be performed at night, at the convenience of the participants' home. Total sleep time reflects the amount of time participants were effectively sleeping while in bed, without periods of wakefulness. This objective measure of participants total sleep time will judge sleep quality against the subjective measures obtained through the sleep questionnaires. |
One night
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Actiwatch: objective changes in total sleep time (TST)
Periodo de tiempo: One week
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Wrist-worn actigraphy is a convenient and reliable way to monitor sleep. Total sleep time reflects the amount of time participants were effectively sleeping while in bed, without periods of wakefulness, on average over seven nights of recording. This objective measure of participants total sleep time will judge sleep quality against the subjective measures obtained through the sleep questionnaires. |
One week
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Change in oxygen levels during sleep
Periodo de tiempo: One night
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A Pulse Oximetry (SPO device from Somnotouch RESP, SomnoMedics) will be clipped at the end of participants' finger overnight together with the PSG recording, pre and post intervention, to measure peripheral capillary oxygen saturation changes. When compared with PSG and Actiwatch measures, oxygen levels can provide additional information about sleep quality. A decrease in oxygen level is often linked to sleep disorders like obstructive sleep apnea. |
One night
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Heart rate during sleep
Periodo de tiempo: One night
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The Pulse Oximetry used for measuring oxygen levels for outcome 31 can also provide information about heart rate during sleep.
Heart rate will be recorded for a full night before and after the intervention, together with PSG.
Heart rate for adults during sleep varies widely across individuals, usually between 40-100 beats per minute.
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One night
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Colaboradores e Investigadores
Patrocinador
Colaboradores
Investigadores
- Investigador principal: Kinjal Doshi, Singapore General Hospital
- Investigador principal: Julian Lim, Duke-NUS Graduate Medical School
Publicaciones y enlaces útiles
Publicaciones Generales
- Lim J, Teng J, Patanaik A, Tandi J, Massar SAA. Dynamic functional connectivity markers of objective trait mindfulness. Neuroimage. 2018 Aug 1;176:193-202. doi: 10.1016/j.neuroimage.2018.04.056. Epub 2018 Apr 27.
- F Wong K, A A Massar S, Chee MWL, Lim J. Towards an Objective Measure of Mindfulness: Replicating and Extending the Features of the Breath-Counting Task. Mindfulness (N Y). 2018;9(5):1402-1410. doi: 10.1007/s12671-017-0880-1. Epub 2018 Jan 22.
- Blackwell T, Yaffe K, Laffan A, Ancoli-Israel S, Redline S, Ensrud KE, Song Y, Stone KL; Osteoporotic Fractures in Men (MrOS) Study Group. Associations of objectively and subjectively measured sleep quality with subsequent cognitive decline in older community-dwelling men: the MrOS sleep study. Sleep. 2014 Apr 1;37(4):655-63. doi: 10.5665/sleep.3562.
- Lim J, Dinges DF. A meta-analysis of the impact of short-term sleep deprivation on cognitive variables. Psychol Bull. 2010 May;136(3):375-89. doi: 10.1037/a0018883.
- Ju YE, Lucey BP, Holtzman DM. Sleep and Alzheimer disease pathology--a bidirectional relationship. Nat Rev Neurol. 2014 Feb;10(2):115-9. doi: 10.1038/nrneurol.2013.269. Epub 2013 Dec 24.
- Lim AS, Kowgier M, Yu L, Buchman AS, Bennett DA. Sleep Fragmentation and the Risk of Incident Alzheimer's Disease and Cognitive Decline in Older Persons. Sleep. 2013 Jul 1;36(7):1027-1032. doi: 10.5665/sleep.2802.
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Palabras clave
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Otros números de identificación del estudio
- 2017/2830
Plan de datos de participantes individuales (IPD)
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