Mechanical Ventilation Discontinuation Practices (IOS)
30 de marzo de 2021 actualizado por: Unity Health Toronto
Practice Pattern Variation in Discontinuing Mechanical Ventilation in Critically Ill Adults: An International Prospective Observational Study
Background: The requirement for ventilator support is a defining feature of critical illness. Weaning is the process during which the work of breathing is transferred from the ventilator back to the patient. Approximately 40% of the total time spent on ventilators is dedicated to weaning. The extent of practice variation in how this complex and expensive technology is discontinued from critically ill patients is unknown. Meanwhile, practice variation has been shown to adversely impact upon patient safety and clinical outcomes.
Purpose: To characterize practice pattern variation in weaning and the consequences of weaning variation by implementing an international, prospective observational study in Canada, the United States, the United Kingdom, Europe, India and Australia/New Zealand.
Primary Objectives: To describe
- weaning practice variation among regions in 5 domains (the use of daily screening, preferred methods of support used before initial discontinuation attempts, use of written protocols, preferred methods of evaluating spontaneous breathing, and sedation and mobilization practices).
- the assocation between selected discontinuation strategies and important clinical outcomes (length of stay, mortality, duration of ventilation).
Methods: The investigators propose to conduct a large scale, observational study involving critically ill adults requiring ventilator support for at least 24 hours to evaluate practices in discontinuing ventilators in 150 centres. The investigators will classify each new admission over the observation period according to the initial strategy that precipitated or facilitated ventilator discontinuation.
Relevance: This novel study will build collaborations with critical care investigators from around the world and industry
Descripción general del estudio
Estado
Terminado
Descripción detallada
Background: The requirement for mechanical ventilation is a defining feature of critical illness. Weaning is the process during which the work of breathing is transferred from the ventilator back to the patient. Approximately 40% of the total time spent on mechanical ventilation is dedicated to weaning. The extent and predictors of practice variation in how this complicated and expensive technology is discontinued from critically ill patients remains unknown. Meanwhile, practice pattern variability has been shown to adversely impact upon patient safety and important clinical outcomes.
Primary Objectives:
- To describe weaning practice variation with regard to the (i) use of daily screening, (ii) preferred methods of support used before initial discontinuation attempts, (iii) use of written weaning and spontaneous breathing trial (SBT) protocols, (iv) preferred methods used to conduct SBTs and (v) sedation and mobilization practices among geographic regions.
To describe the association between variation in weaning practices (direct extubation, tracheostomy, SBT conduct) and important clinical outcomes.
Secondary Objectives:
- To identify baseline and time-dependent factors associated with use of selected strategies.
- Among critically ill adults who undergo an initial SBT, the investigators will: a) investigate associations between SBT outcome (success/failure) and clinical outcomes, b) explore differences between critically ill patients who undergo an SBT early versus later in their intensive care unit (ICU) stay, and c) investigate the impact of different SBT techniques and humidification strategies on outcomes.
- To identify important predictors (patient, clinician, SBT, institutional and regional) of SBT outcome.
Study Design and Population: The investigators propose to conduct an international prospective observational study of mechanical ventilation discontinuation practices in 150 ICUs involving all newly admitted critically ill adults requiring invasive ventilation for at least 24 hours.
Study Centres: Interested centres have been identified through completion of an information card enclosed in a previously administered International Weaning Survey. The investigators will use a multimodal approach to identify participating centers in each of the 6 geographic regions (Canada, the United States, the United Kingdom, Europe, India and Australia/New Zealand).
Study Outcomes: The investigators will classify each new admission over the study week according to the initial strategy that precipitated or facilitated mechanical ventilation discontinuation into one of five categories: direct extubation, tracheostomy, SBT success, SBT failure or death. The investigator will describe the association between the use of alternative discontinuation strategies and important clinical outcomes (e.g., mortality, ICU and hospital stay, ICU readmission and reintubation rates).
Relevance: Through collaborations with industry partners and international colleagues we will implement this large scale observational study to quantify the existence and extent of practice variation in weaning. Information obtained from this study will inform the design of future studies aimed at reducing weaning practice variation and improving outcomes in critically ill patients receiving invasive mechanical ventilation
Tipo de estudio
De observación
Inscripción (Actual)
1868
Contactos y Ubicaciones
Esta sección proporciona los datos de contacto de quienes realizan el estudio e información sobre dónde se lleva a cabo este estudio.
Ubicaciones de estudio
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Ontario
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Hamilton, Ontario, Canadá
- St. Joseph's Hospital
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Hamilton, Ontario, Canadá, L8L2X2
- Hamilton Health Sciences Hamilton General Hospital
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Hamilton, Ontario, Canadá
- Juravinski Hospital Cancer Centre
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London, Ontario, Canadá, N6A 5A5
- London Health Sciences Centre - University Hospital Campus
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Ottawa, Ontario, Canadá
- Ottawa Civic Hospital
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Ottawa, Ontario, Canadá
- Ottawa General Hospital
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Toronto, Ontario, Canadá, M5B 1W8
- St. Michael's Hospital
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Toronto, Ontario, Canadá
- Mount Sinai Hospital
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Quebec
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Montréal, Quebec, Canadá, H2X 3J4
- Hôpital Saint-Luc
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Sherbrooke, Quebec, Canadá
- Université de Sherbrooke
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Sherbrooke, Quebec, Canadá
- Universite Hopitalier de Sherbrooke
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Trois-Rivières, Quebec, Canadá, G9A5C5
- Ciusss McQ
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-
-
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Massachusetts
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Boston, Massachusetts, Estados Unidos, 02111
- Tufts Medical Center
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Michigan
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Ann Arbor, Michigan, Estados Unidos, 48109
- University of Michigan Health System
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-
Criterios de participación
Los investigadores buscan personas que se ajusten a una determinada descripción, denominada criterio de elegibilidad. Algunos ejemplos de estos criterios son el estado de salud general de una persona o tratamientos previos.
Criterio de elegibilidad
Edades elegibles para estudiar
16 años y mayores (Niño, Adulto, Adulto Mayor)
Acepta Voluntarios Saludables
No
Géneros elegibles para el estudio
Todos
Método de muestreo
Muestra no probabilística
Población de estudio
We propose to conduct an International, Prospective Observational Study of Mechanical Ventilation Discontinuation Practices among critically ill adults who receive invasive mechanical ventilation for at least 24 (i.e., > or equal to 24) hours in approximately 150 international ICUs
Descripción
Inclusion Criteria:
- All newly admitted critically ill adults after study initiation at participating ICUs.
- Requiring invasive mechanical ventilation for at least 24 (i.e. > or equal to 24) hours
Exclusion Criteria:
- Transferred to a participating ICU without a clear time of intubation
- Tracheotomy/tracheostomy present at the time of ICU admission
- Already on ventilator settings compatible with a SBT [e.g., T-piece or Continuous Positive Airway Pressure < or =5 cm H2O (water) or Pressure Support < or = 8 cm H2O (with or without PEEP) or Automatic Tube Compensation (ATC) or equivalent] at the time of ICU admission
- Patient residing in ICU for > or = 24 hours at the time of the study activation (i.e., not a new admission from the time of study activation).
- Patient readmitted to this ICU during the study period (i.e., would constitute a second inclusion) unless they were ineligible during their first admission
- Patients participating in studies (e.g., randomized controlled trials) with explicit weaning protocols incorporated into the study design
Plan de estudios
Esta sección proporciona detalles del plan de estudio, incluido cómo está diseñado el estudio y qué mide el estudio.
¿Cómo está diseñado el estudio?
Detalles de diseño
Cohortes e Intervenciones
Grupo / Cohorte |
|---|
|
INITIAL SBT
Patients who underwent an Spontaneous Breathing Trial prior to extubation.
This cohort will be further subdivided into initial patients who initially pass an SBT successes and those who initially fail an SBT.
|
|
DIRECT EXTUBATION
Patients that were directly extubated without conduct of a prior SBT or tracheostomy
|
|
DIRECT TRACHEOSTOMY
Patients who underwent a direct tracheostomy without conduct of a prior SBT or extubation
|
|
No attempt at mechanical ventilation discontinuation
Patients who died without conduct of a prior SBT, extubation or tracheostomy
|
¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
|
Practice variation among geographic regions in the use of daily screening to identify candidates to undergo an SBT
Periodo de tiempo: Through study completion (approximately 4 years)
|
Use of once daily screening in clinical practice
|
Through study completion (approximately 4 years)
|
|
Practice variation among geographic regions in the preferred methods of ventilator support used before initial discontinuation attempts
Periodo de tiempo: Through study completion (approximately 4 years)
|
Differences in ventilator modes (Pressure Support, Assist Control, other) prior to discontinuation attempts
|
Through study completion (approximately 4 years)
|
|
Practice variation among geographic regions in the use of written weaning and SBT protocols
Periodo de tiempo: Through study completion (approximately 4 years)
|
Use of written protocols to liberate patients from ventilators
|
Through study completion (approximately 4 years)
|
|
Practice variation among geographic regions in the methods used to conduct SBTs (and humidify oxygen)
Periodo de tiempo: Through study completion (approximately 4 years)
|
Use of different techniques to conduct SBTs (Pressure Support, T-piece, etc.)
|
Through study completion (approximately 4 years)
|
|
Practice variation among geographic regions in the sedation and mobilization practices during weaning
Periodo de tiempo: Through study completion (approximately 4 years)
|
Use of different levels of sedation (Sedation Agitation Scale) and levels of mobilization (active, passive, none)
|
Through study completion (approximately 4 years)
|
|
Association between variation in the weaning practices and total duration of ventilation.
Periodo de tiempo: Through study completion (approximately 4 years)
|
We will describe the association between variation in the weaning practices and the total duration of ventilation.
|
Through study completion (approximately 4 years)
|
|
Association between variation in the weaning practices and ICU mortality
Periodo de tiempo: Through study completion (approximately 4 years)
|
We will describe the association between variation in the weaning practices and ICU mortality.
|
Through study completion (approximately 4 years)
|
|
Association between variation in the weaning practices and hospital mortality.
Periodo de tiempo: Through study completion (approximately 4 years)
|
We will describe the association between variation in the weaning practices and hospital mortality.
|
Through study completion (approximately 4 years)
|
|
Association between variation in the weaning practices and the proportion of patients off the ventilator at day 28.
Periodo de tiempo: Through study completion (approximately 4 years)
|
We will describe the association between variation in the weaning practices and the proportion of patients off the ventilator at day 28.
|
Through study completion (approximately 4 years)
|
|
Association between variation in the weaning practices and the proportion of patients out of the ICU at day 28.
Periodo de tiempo: Through study completion (approximately 4 years)
|
We will describe the association between variation in the weaning practices and the proportion of patients out of the ICU at day 28.
|
Through study completion (approximately 4 years)
|
|
Association between variation in the weaning practices and ICU LOS.
Periodo de tiempo: Through study completion (approximately 4 years)
|
We will describe the association between variation in the weaning practices and ICU LOS (total and among survivors and non survivors).
|
Through study completion (approximately 4 years)
|
|
Association between variation in the weaning practices and hospital LOS.
Periodo de tiempo: Through study completion (approximately 4 years)
|
We will describe the association between variation in the weaning practices and hospital LOS (total and among survivors and non survivors).
|
Through study completion (approximately 4 years)
|
|
Association between variation in the weaning practices and ICU readmission.
Periodo de tiempo: Through study completion (approximately 4 years)
|
We will describe the association between variation in the weaning practices and ICU readmission (during the current hospitalization).
|
Through study completion (approximately 4 years)
|
|
Association between variation in the weaning practices and reintubation.
Periodo de tiempo: Through study completion (approximately 4 years)
|
We will describe the association between variation in the weaning practices and reintubation (or repeat ventilation following disconnection in tracheostomized patients) within 48 hours of extubation.
|
Through study completion (approximately 4 years)
|
Medidas de resultado secundarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
|
Identify baseline characteristics and time-dependent factors associated with use of selected strategy (direct extubation, direct tracheostomy, Initial SBT) to discontinue mechanical ventilation
Periodo de tiempo: Through study completion (approximately 4 years)
|
We will use cox proportion hazards modelling to identify baseline characteristics and time-dependent factors (development of adult respiratory distress syndrome, heart failure, acute kidney injury requiring dialysis) associated with the use of selected discontinuation strategies (direct extubation, direct tracheostomy, Initial SBT)
|
Through study completion (approximately 4 years)
|
|
Association between initial SBT outcome (success/failure) and total duration of ventilation.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Describe the associations between SBT outcome (success/failure) and the total duration of ventilation.
|
Through study completion (approximately 4 years)
|
|
Association between initial SBT outcome (success/failure) and ICU mortality.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Describe the associations between SBT outcome (success/failure) and ICU mortality.
|
Through study completion (approximately 4 years)
|
|
Association between initial SBT outcome (success/failure) and hospital mortality.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Describe the associations between SBT outcome (success/failure) and hospital mortality.
|
Through study completion (approximately 4 years)
|
|
Association between initial SBT outcome (success/failure) and the proportion of patients off of the ventilator at day 28
Periodo de tiempo: Through study completion (approximately 4 years)
|
Describe the associations between SBT outcome (success/failure) and the proportion of patients off the ventilator at day 28.
|
Through study completion (approximately 4 years)
|
|
Association between initial SBT outcome (success/failure) and the proportion of patients out of the ICU at day 28.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Describe the associations between SBT outcome (success/failure) and the proportion of patients out of the ICU at day 28.
|
Through study completion (approximately 4 years)
|
|
Association between initial SBT outcome (success/failure) and ICU LOS.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Describe the associations between SBT outcome (success/failure) and ICU LOS (total and among survivors and non survivors.
|
Through study completion (approximately 4 years)
|
|
Association between initial SBT outcome (success/failure) and hospital LOS.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Describe the associations between SBT outcome (success/failure) and hospital LOS (total and among survivors and non survivors.
|
Through study completion (approximately 4 years)
|
|
Association between initial SBT outcome (success/failure) and ICU readmission.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Association between initial SBT outcome (success/failure) and ICU readmission (during the current hospitalization).
|
Through study completion (approximately 4 years)
|
|
Association between initial SBT outcome (success/failure) and reintubation.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Describe the associations between SBT outcome (success/failure) and reintubation (or repeat ventilation following disconnection in tracheostomized patients) within 48 hours of extubation c) Describe the association between different SBT techniques on clinical outcomes and d) Describe the association between use of selected humidification strategies and clinical outcomes. |
Through study completion (approximately 4 years)
|
|
Differences in clinical outcomes between patients who undergo an SBT early versus later in their ICU stay on the total duration of ventilation.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Associations between use of different SBT technique (e.g., Pressure Support, T-piece) and the impact on the total duration of ventilation.
|
Through study completion (approximately 4 years)
|
|
Differences in clinical outcomes between patients who undergo an SBT early versus later in their ICU stay on ICU mortality.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Associations between use of different SBT technique (e.g., Pressure Support, T-piece) and the impact on ICU mortality.
|
Through study completion (approximately 4 years)
|
|
Differences in clinical outcomes between patients who undergo an SBT early versus later in their ICU stay on hospital mortality.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Associations between use of different SBT technique (e.g., Pressure Support, T-piece) and the impact on hospital mortality.
|
Through study completion (approximately 4 years)
|
|
Differences in clinical outcomes between patients who undergo an SBT early versus later in their ICU stay on the proportion of patients off the ventilator at day 28.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Associations between use of different SBT technique (e.g., Pressure Support, T-piece) and the impact on the proportion of patients off the ventilator at day 28.
|
Through study completion (approximately 4 years)
|
|
Differences in clinical outcomes between patients who undergo an SBT early versus later in their ICU stay on the proportion of patients out of the ICU at day 28.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Associations between use of different SBT technique (e.g., Pressure Support, T-piece) and the impact on the proportion of patients out of the ICU at day 28.
|
Through study completion (approximately 4 years)
|
|
Differences in clinical outcomes between patients who undergo an SBT early versus later in their ICU stay on ICU LOS.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Associations between use of different SBT technique (e.g., Pressure Support, T-piece) and the impact on ICU LOS (total and among survivors and non survivors).
|
Through study completion (approximately 4 years)
|
|
Differences in clinical outcomes between patients who undergo an SBT early versus later in their ICU stay on hospital LOS.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Associations between use of different SBT technique (e.g., Pressure Support, T-piece) and the impact on hospital LOS (total and among survivors and non survivors).
|
Through study completion (approximately 4 years)
|
|
Differences in clinical outcomes between patients who undergo an SBT early versus later in their ICU stay on ICU readmission.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Associations between use of different SBT technique (e.g., Pressure Support, T-piece) and the impact on ICU readmission (during the current hospitalization).
|
Through study completion (approximately 4 years)
|
|
Differences in clinical outcomes between patients who undergo an SBT early versus later in their ICU stay on reintubation.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Associations between use of different SBT technique (e.g., Pressure Support, T-piece) and the impact on reintubation (or repeat ventilation following disconnection in tracheostomized patients) within 48 hours of extubation.
|
Through study completion (approximately 4 years)
|
|
Association between different SBT techniques and total duration of ventilation.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Associations between use of different SBT technique (e.g., Pressure Support, T-piece) and the impact on the total duration of ventilation.
|
Through study completion (approximately 4 years)
|
|
Association between different SBT techniques and ICU mortality.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Associations between use of different SBT technique (e.g., Pressure Support, T-piece) and the impact on ICU mortality.
|
Through study completion (approximately 4 years)
|
|
Association between different SBT techniques and hospital mortality.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Associations between use of different SBT technique (e.g., Pressure Support, T-piece) and the impact on hospital mortality.
|
Through study completion (approximately 4 years)
|
|
Association between different SBT techniques and the proportion of patients off the ventilator at day 28.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Associations between use of different SBT technique (e.g., Pressure Support, T-piece) and the impact on the proportion of patients off the ventilator at day 28.
|
Through study completion (approximately 4 years)
|
|
Association between different SBT techniques and the proportion of patients out of the ICU at day 28.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Associations between use of different SBT technique (e.g., Pressure Support, T-piece) and the impact on the proportion of patients out of the ICU at day 28.
|
Through study completion (approximately 4 years)
|
|
Association between different SBT techniques and ICU LOS.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Associations between use of different SBT technique (e.g., Pressure Support, T-piece) and the impact on ICU LOS (total and among survivors and non survivors).
|
Through study completion (approximately 4 years)
|
|
Association between different SBT techniques and hospital LOS.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Associations between use of different SBT technique (e.g., Pressure Support, T-piece) and the impact on hospital LOS (total and among survivors and non survivors).
|
Through study completion (approximately 4 years)
|
|
Association between different SBT techniques and ICU readmission.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Associations between use of different SBT technique (e.g., Pressure Support, T-piece) and the impact on ICU readmission (during the current hospitalization).
|
Through study completion (approximately 4 years)
|
|
Association between different SBT techniques and reintubation.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Associations between use of different SBT technique (e.g., Pressure Support, T-piece) and the impact on reintubation (or repeat ventilation following disconnection in tracheostomized patients) within 48 hours of extubation
|
Through study completion (approximately 4 years)
|
|
Association between use of selected humidification strategies and the total duration of ventilation.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Associations between use of different humidification strategies (e.g., Heat and Moisture Exchanger, heated humidifier) and the impact on the total duration of ventilation.
|
Through study completion (approximately 4 years)
|
|
Association between use of selected humidification strategies and ICU mortality.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Associations between use of different humidification strategies (e.g., Heat and Moisture Exchanger, heated humidifier) and the impact on ICU mortality.
|
Through study completion (approximately 4 years)
|
|
Association between use of selected humidification strategies and hospital mortality.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Associations between use of different humidification strategies (e.g., Heat and Moisture Exchanger, heated humidifier) and the impact on hospital mortality.
|
Through study completion (approximately 4 years)
|
|
Association between use of selected humidification strategies and the proportion of patients off the ventilator at day 28.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Associations between use of different humidification strategies (e.g., Heat and Moisture Exchanger, heated humidifier) and the impact on the proportion of patients off the ventilator at day 28.
|
Through study completion (approximately 4 years)
|
|
Association between use of selected humidification strategies and the proportion of patients out of the ICU at day 28.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Associations between use of different humidification strategies (e.g., Heat and Moisture Exchanger, heated humidifier) and the impact on the proportion of patients out of the ICU at day 28.
|
Through study completion (approximately 4 years)
|
|
Association between use of selected humidification strategies and ICU LOS.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Associations between use of different humidification strategies (e.g., Heat and Moisture Exchanger, heated humidifier) and the impact on ICU LOS (total and among survivors and non survivors).
|
Through study completion (approximately 4 years)
|
|
Association between use of selected humidification strategies and hospital LOS.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Associations between use of different humidification strategies (e.g., Heat and Moisture Exchanger, heated humidifier) and the impact on hospital LOS (total and among survivors and non survivors).
|
Through study completion (approximately 4 years)
|
|
Association between use of selected humidification strategies and ICU readmission.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Associations between use of different humidification strategies (e.g., Heat and Moisture Exchanger, heated humidifier) and the impact on ICU readmission (during the current hospitalization).
|
Through study completion (approximately 4 years)
|
|
Association between use of selected humidification strategies and reintubation.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Associations between use of different humidification strategies (e.g., Heat and Moisture Exchanger, heated humidifier) and the impact on reintubation (or repeat ventilation following disconnection in tracheostomized patients) within 48 hours of extubation.
|
Through study completion (approximately 4 years)
|
Otras medidas de resultado
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
|
Predictors of initial SBT outcome.
Periodo de tiempo: Through study completion (approximately 4 years)
|
Describe important predictors (patient, clinician, SBT, institutional and regional-related) of initial SBT outcome (SBT success and failure) using a single regression analysis.
One analysis will be conducted to describe significant predictors.
|
Through study completion (approximately 4 years)
|
Colaboradores e Investigadores
Aquí es donde encontrará personas y organizaciones involucradas en este estudio.
Patrocinador
Investigadores
- Investigador principal: Karen E.A. Burns, MD, FRCPC, MSc, St. Michael's Hospital, Li Ka Shing Knowledge Institute, University of Toronto
Publicaciones y enlaces útiles
La persona responsable de ingresar información sobre el estudio proporciona voluntariamente estas publicaciones. Estos pueden ser sobre cualquier cosa relacionada con el estudio.
Publicaciones Generales
- Burns KEA, Rizvi L, Cook DJ, Lebovic G, Dodek P, Villar J, Slutsky AS, Jones A, Kapadia FN, Gattas DJ, Epstein SK, Pelosi P, Kefala K, Meade MO; Canadian Critical Care Trials Group. Ventilator Weaning and Discontinuation Practices for Critically Ill Patients. JAMA. 2021 Mar 23;325(12):1173-1184. doi: 10.1001/jama.2021.2384.
- Burns KEA, Rizvi L, Cook DJ, Dodek P, Slutsky AS, Jones A, Villar J, Kapadia FN, Gattas DJ, Epstein SK, Meade MO; Canadian Critical Care Trials Group. Variation in the practice of discontinuing mechanical ventilation in critically ill adults: study protocol for an international prospective observational study. BMJ Open. 2019 Sep 8;9(9):e031775. doi: 10.1136/bmjopen-2019-031775.
Fechas de registro del estudio
Estas fechas rastrean el progreso del registro del estudio y los envíos de resultados resumidos a ClinicalTrials.gov. Los registros del estudio y los resultados informados son revisados por la Biblioteca Nacional de Medicina (NLM) para asegurarse de que cumplan con los estándares de control de calidad específicos antes de publicarlos en el sitio web público.
Fechas importantes del estudio
Inicio del estudio (Actual)
4 de noviembre de 2013
Finalización primaria (Actual)
17 de diciembre de 2016
Finalización del estudio (Actual)
17 de diciembre de 2016
Fechas de registro del estudio
Enviado por primera vez
3 de mayo de 2019
Primero enviado que cumplió con los criterios de control de calidad
16 de mayo de 2019
Publicado por primera vez (Actual)
20 de mayo de 2019
Actualizaciones de registros de estudio
Última actualización publicada (Actual)
2 de abril de 2021
Última actualización enviada que cumplió con los criterios de control de calidad
30 de marzo de 2021
Última verificación
1 de marzo de 2021
Más información
Términos relacionados con este estudio
Términos MeSH relevantes adicionales
Otros números de identificación del estudio
- 11-024
Información sobre medicamentos y dispositivos, documentos del estudio
Estudia un producto farmacéutico regulado por la FDA de EE. UU.
No
Estudia un producto de dispositivo regulado por la FDA de EE. UU.
No
Esta información se obtuvo directamente del sitio web clinicaltrials.gov sin cambios. Si tiene alguna solicitud para cambiar, eliminar o actualizar los detalles de su estudio, comuníquese con register@clinicaltrials.gov. Tan pronto como se implemente un cambio en clinicaltrials.gov, también se actualizará automáticamente en nuestro sitio web. .