Effect of Advanced PRF and Hyaluronic Acid on Dental Implant Healing
Clinical Efficacy of A-PRF With Hyaluronic Acid" in Enhancing Bone Formation in Dental Implantation
Descripción general del estudio
Estado
Condiciones
Tipo de estudio
Inscripción (Estimado)
Fase
- No aplica
Contactos y Ubicaciones
Estudio Contacto
- Nombre: Samar A Salamah, BDS
- Número de teléfono: +967777277949
- Correo electrónico: samarali777277949@gmail.com
Ubicaciones de estudio
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Sana'a
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Sanaa, Sana'a, Yemen
- Reclutamiento
- Beauty Smile Dental Center
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Contacto:
- Samar A Salamah, BDS
- Número de teléfono: +967777277949
- Correo electrónico: samarali777277949@gmail.com
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Contacto:
- Samar A Salamah, BDS
- Correo electrónico: samarali777277949@gmail.com
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Criterios de participación
Criterio de elegibilidad
Edades elegibles para estudiar
- Adulto
- Adulto Mayor
Acepta Voluntarios Saludables
Descripción
Inclusion Criteria:
- Adults aged 18-65 years.
Patients requiring delayed dental implant placement in a posterior mandibular edentulous site
Sufficient residual alveolar bone height and width to permit conventional implant placement without the need for simultaneous guided bone regeneration (GBR), ridge augmentation, or other bone-grafting procedures.
Good general health or a medically controlled and stable systemic condition compatible with elective implant surgery and not expected to materially compromise wound or bone healing.
Non-smokers with no current use of tobacco products.
Acceptable oral hygiene and a periodontal condition compatible with implant surgery following any required professional treatment and reassessment.
Ability and willingness to undergo the required clinical and radiographic assessments, including CBCT examinations at baseline and at the 6-month follow-up.
Ability and willingness to attend the scheduled follow-up visits and comply with the study procedures.
Provision of written informed consent before study participation.
Exclusion Criteria:
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Any uncontrolled systemic disease or medical condition that conensions for conventional implant placement without augmentation.
Requirement for immediate implant placement, simultaneous guided bone regeneration, ridge augmentation, or any other adjunctive bone-grafting procedure.
Inability or unwillingness to complete the required 6-month clinical and radiographic follow-up.traindicates elective implant surgery or may substantially impair wound or bone healing, including uncontrolled diabetes mellitus.
Immunocompromised status or current systemic immunosuppressive therapy.
Current or previous use of oral or parenteral bisphosphonates or other antiresorptive medications associated with a risk of medication-related osteonecrosis of the jaw.
Pregnancy at the time of screening or enrollment.
Unresolved active periodontal disease or active local infection involving the intended implant site, including suppuration.
Inadequate oral hygiene that persists after professional oral-hygiene instruction, necessary periodontal treatment, and reassessment.
Insufficient residual alveolar bone dim
Plan de estudios
¿Cómo está diseñado el estudio?
Detalles de diseño
- Propósito principal: Tratamiento
- Asignación: Aleatorizado
- Modelo Intervencionista: Asignación paralela
- Enmascaramiento: Único
Armas e Intervenciones
Grupo de participantes/brazo |
Intervención / Tratamiento |
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Experimental: Dental Implant + A-PRF and Hyaluronic Acid
Participants receive delayed dental implant placement with adjunctive application of advanced platelet-rich fibrin (A-PRF) combined with hyaluronic acid at the implant site.
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A dental implant was surgically placed into a healed edentulous site using a standardized delayed-placement protocol.
This procedure was performed in both the test and control groups.
Autologous advanced platelet-rich fibrin (A-PRF) was prepared from the participants' venous blood using a standardized centrifugation protocol and applied at the dental implant site.
In the test group, A-PRF was used in combination with hyaluronic acid as an adjunct to delayed dental implant placement.
In the test group, 1.5% hyaluronic acid is combined with autologous advanced platelet-rich fibrin (A-PRF) and applied locally at the dental implant site during delayed dental implant placement.
The control group does not receive hyaluronic acid.
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Comparador activo: Dental Implant Alone
Participants receive delayed dental implant placement without adjunctive A-PRF or hyaluronic acid.
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A dental implant was surgically placed into a healed edentulous site using a standardized delayed-placement protocol.
This procedure was performed in both the test and control groups.
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¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
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CBCT-Derived Peri-Implant Bone Volume
Periodo de tiempo: Baseline and 6 months after implant placement
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The peri-implant bone volume will be assessed using cone-beam computed tomography (CBCT) at baseline and 6 months after dental implant placement.
Changes in bone volume between baseline and the 6-month follow-up will be evaluated and compared between the test and control groups.
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Baseline and 6 months after implant placement
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CBCT-Derived Peri-Implant Radiographic Density
Periodo de tiempo: Baseline and 6 months after implant placement
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Peri-implant radiographic density will be assessed using cone-beam computed tomography (CBCT) at baseline and 6 months after dental implant placement.
Changes in radiographic density between baseline and the 6-month follow-up will be evaluated and compared between the test and control groups.
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Baseline and 6 months after implant placement
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Medidas de resultado secundarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
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Implant Stability Quotient (ISQ)
Periodo de tiempo: At implant placement and 6 months after implant placement
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Implant stability will be assessed using resonance frequency analysis and expressed as Implant Stability Quotient (ISQ) values.
ISQ will be measured at the time of implant placement and at the 6-month follow-up, and changes will be compared between the test and control groups.
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At implant placement and 6 months after implant placement
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Dental Implant Survival Rate at 6 Months
Periodo de tiempo: Up to 6 months after implant placement
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Implant survival will be assessed by determining whether the dental implant remains in situ and clinically functional without removal during the 6-month follow-up period.
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Up to 6 months after implant placement
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Colaboradores e Investigadores
Patrocinador
Investigadores
- Investigador principal: Samar A salamah, BDS, Sana'a University
Fechas de registro del estudio
Fechas importantes del estudio
Inicio del estudio (Actual)
Finalización primaria (Estimado)
Finalización del estudio (Estimado)
Fechas de registro del estudio
Enviado por primera vez
Primero enviado que cumplió con los criterios de control de calidad
Publicado por primera vez (Actual)
Actualizaciones de registros de estudio
Última actualización publicada (Actual)
Última actualización enviada que cumplió con los criterios de control de calidad
Última verificación
Más información
Términos relacionados con este estudio
Palabras clave
Otros números de identificación del estudio
- OMFS-033\06\2025
Plan de datos de participantes individuales (IPD)
¿Planea compartir datos de participantes individuales (IPD)?
Descripción del plan IPD
Información sobre medicamentos y dispositivos, documentos del estudio
Estudia un producto farmacéutico regulado por la FDA de EE. UU.
Estudia un producto de dispositivo regulado por la FDA de EE. UU.
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