Effects of a Multi-Targeted Oral Supplement on Skin, Hair, Sleep, Energy, Cognition, Libido and Epigenetic Biological Clock Age (IDF-AID-1)

Inclusion Criteria:

• Healthy adults aged 35 to 65 years (30% male : 70% female desired)
• In generally good health, as determined by medical history questionnaire
• Free from excessive hair, tattoos, dermatitis or scars on the test areas; males must attend each visit clean shaven, having shaved the day before the appointment
• Able to read, understand and sign an informed consent agreement
• Able to communicate well with study personnel and comply with study requirements
• Hair at least 3 cm long, with no intention of substantial change to hair style
• Participants on medicinal contraception: stable method for at least 3 months prior to baseline and willing not to change for the study duration
• Women of childbearing potential: willing to use a reliable method of contraception
• Participants on hormone replacement therapy: stable HRT for at least 6 months prior to baseline and willing not to change
• Willing not to change regular food habits or commence any diet or nutritional change
• Willing to refrain from taking any new dietary supplements other than study products
• Willing to maintain usual lifestyle habits including exercise regimes
• Willing to avoid medicated shampoo and conditioner
• Willing to refrain from dermato-aesthetic facial procedures
• Willing to refrain from chemical hair styling procedures (colour treatments permitted)
• Willing to avoid excessive natural sunlight and other avoidable UV sources
• Willing to remove facial piercings, earrings or jewellery prior to imaging
• Willing to consent to use of their images by the Sponsor
• Willing to have photographs taken to record any significant reactions
• Willing to adhere to all study restrictions and requirements

Exclusion Criteria:

• - Pregnant, breastfeeding, or of childbearing potential and not using reliable contraception
• Consumed any food or health supplements (including vitamins, creatine, omegas, collagen) within the 3 months prior to baseline
• Known allergy or hypersensitivity to any study product ingredient (products contain fish and coconut ingredients)
• Known allergy or hypersensitivity to any dietary supplements
• Any systemic condition (acute or chronic) or skin disorder including eczema, psoriasis, acne or diabetes (inactive skin disease for at least 6 months prior to baseline may be accepted at the Project Manager's discretion)
• History of skin cancer with remission period below 5 years
• Asthma or other chronic respiratory condition requiring therapy within the last 6 months
• Any other systemic disease or medical or skin condition which in the opinion of the Project Manager, Study Doctor or Sponsor would affect ability to complete the study
• Diagnosis of high cholesterol (current or previous)
• Current treatment with cholesterol lowering medication
• Family history of high cholesterol (first degree relative)
• Diagnosis of ischaemic heart disease (current or previous)
• Diagnosis of peripheral vascular disease or intermittent claudication
• Diagnosis of stroke (current or previous)
• Treatment (oral or topical) with tretinoin, isotretinoin or corticosteroids within the 6 months prior to baseline
• Systemic steroids or anti-inflammatory treatments within the 6 months prior to baseline
• Medications which may affect sampling or analysis, including metformin, anticoagulants, biological therapies, immunosuppressive or immunomodulating medication, chemotherapy, cytokine or anti-cytokine therapy
• Surgical or non-surgical dermato-aesthetic facial procedures within the 6 months prior to baseline
• Facial surgery (excluding dental) within the previous 6 months
• Diagnosis of facial nerve damage
• False eyelashes of any type on assessment days
• Refusal to remove eyebrow make-up
• Facial or ear piercings that cannot be removed for assessments
• Low protein diet
• Vegetarian or vegan diet (study products contain marine collagen and bovine gelatine)
• Average alcohol consumption greater than 14 units per week
• Night shift workers or irregular working hours interfering with regular sleep pattern
• Intention to commence smoking cessation activities or alternative nicotine products during the study
• Medically diagnosed insomnia
• Active medically diagnosed alopecia or previous history
• History of or high risk of blood borne infection (HIV, hepatitis B or C, AIDS)
• History of problematic blood collections or negative experience during surgery