Rituximab et chimiothérapie combinée avec ou sans lénalidomide dans le traitement des patients atteints d'un lymphome diffus à grandes cellules B de stade II-IV nouvellement diagnostiqué
24 octobre 2026 mis à jour par: National Cancer Institute (NCI)
Étude ouverte randomisée de phase II comparant le lénalidomide R-CHOP (R2CHOP) à RCHOP (rituximab, cyclophosphamide, doxorubicine, vincristine et prednisone) chez des patients atteints d'un lymphome diffus à grandes cellules B nouvellement diagnostiqué
This randomized phase II trial studies how well rituximab and combination chemotherapy with or without lenalidomide work in treating patients with newly diagnosed stage II-IV diffuse large B cell lymphoma. Monoclonal antibodies, such as rituximab, may interfere with the ability of cancer cells to grow and spread. Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Lenalidomide may stimulate the immune system in different ways and stop cancer cells from growing. It is not yet known whether rituximab and combination chemotherapy are more effective when given with or without lenalidomide in treating patients with diffuse large B cell lymphoma.
Aperçu de l'étude
Statut
Actif, ne recrute pas
Les conditions
Description détaillée
PRIMARY OBJECTIVES:
I. Progression-free survival (PFS).
SECONDARY OBJECTIVES:
I. Response rate (RR). II. Complete remission (CR) rate as defined by positron emission tomography (PET)-computed tomography (CT) criteria.
III. Overall survival (OS).
TERTIARY OBJECTIVES:
I. Impact of diffuse large B cell lymphoma (DLBCL) molecular subtype on outcome.
II. Interim PET scan results in relation to treatment outcome.
OUTLINE: Patients are randomized to 1 of 2 treatment arms.
ARM A: Patients receive rituximab intravenously (IV), cyclophosphamide IV, doxorubicin hydrochloride IV, and vincristine sulfate IV on day 1; prednisone orally (PO) on days 1-5; and lenalidomide PO on days 1-10. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity.
ARM B: Patients receive rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone as in Arm A. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 3 months for 2 years, every 6 months for 1 year, and then annually for up to 7 years.
Type d'étude
Interventionnel
Inscription (Réel)
349
Phase
- Phase 2
Contacts et emplacements
Cette section fournit les coordonnées de ceux qui mènent l'étude et des informations sur le lieu où cette étude est menée.
Lieux d'étude
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Alaska
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Anchorage, Alaska, États-Unis, 99508
- Alaska Breast Care and Surgery LLC
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Anchorage, Alaska, États-Unis, 99508
- Alaska Women's Cancer Care
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Anchorage, Alaska, États-Unis, 99508
- Anchorage Oncology Centre
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Anchorage, Alaska, États-Unis, 99508
- Katmai Oncology Group
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Anchorage, Alaska, États-Unis, 99508
- Providence Alaska Medical Center
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Arizona
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Scottsdale, Arizona, États-Unis, 85259
- Mayo Clinic in Arizona
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Tucson, Arizona, États-Unis, 85719
- Banner University Medical Center - Tucson
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Tucson, Arizona, États-Unis, 85719
- University of Arizona Cancer Center-North Campus
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Arkansas
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Little Rock, Arkansas, États-Unis, 72205
- John L McClellan Memorial Veterans Hospital
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California
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Antioch, California, États-Unis, 94531
- Kaiser Permanente-Deer Valley Medical Center
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Auburn, California, États-Unis, 95602
- Sutter Auburn Faith Hospital
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Baldwin Park, California, États-Unis, 91706
- Kaiser Permanente-Baldwin Park
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Bellflower, California, États-Unis, 90706
- Kaiser Permanente-Bellflower
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Burbank, California, États-Unis, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Harbor City, California, États-Unis, 90710
- Kaiser Permanente South Bay
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Irvine, California, États-Unis, 92618
- Kaiser Permanente-Irvine
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Loma Linda, California, États-Unis, 92354
- Loma Linda University Medical Center
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Modesto, California, États-Unis, 95355
- Memorial Medical Center
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Mountain View, California, États-Unis, 94040
- Palo Alto Medical Foundation-Camino Division
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Mountain View, California, États-Unis, 94040
- Palo Alto Medical Foundation-Gynecologic Oncology
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Oakland, California, États-Unis, 94611
- Kaiser Permanente-Oakland
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Orange, California, États-Unis, 92868
- UC Irvine Health/Chao Family Comprehensive Cancer Center
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Palo Alto, California, États-Unis, 94304
- Stanford Cancer Institute Palo Alto
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Palo Alto, California, États-Unis, 94301
- Palo Alto Medical Foundation Health Care
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Panorama City, California, États-Unis, 91402
- Kaiser Permanente - Panorama City
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Richmond, California, États-Unis, 94801
- Kaiser Permanente-Richmond
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Sacramento, California, États-Unis, 95816
- Sutter Medical Center Sacramento
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Sacramento, California, États-Unis, 95823
- Kaiser Permanente-South Sacramento
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Sacramento, California, États-Unis, 95825
- Kaiser Permanente Sacramento Medical Center
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San Diego, California, États-Unis, 92120
- Kaiser Permanente-San Diego Zion
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San Diego, California, États-Unis, 92108
- Kaiser Permanente-Rio San Diego
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San Francisco, California, États-Unis, 94115
- Kaiser Permanente-San Francisco
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San Francisco, California, États-Unis, 94115
- California Pacific Medical Center-Pacific Campus
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San Jose, California, États-Unis, 95119
- Kaiser Permanente-Santa Teresa-San Jose
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San Jose, California, États-Unis, 95124
- Stanford Cancer Center South Bay
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San Marcos, California, États-Unis, 92078
- Kaiser Permanente-San Marcos
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San Rafael, California, États-Unis, 94903
- Kaiser Permanente-San Rafael
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Santa Clara, California, États-Unis, 95051
- Kaiser Permanente Medical Center - Santa Clara
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Santa Cruz, California, États-Unis, 95065
- Palo Alto Medical Foundation-Santa Cruz
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Santa Rosa, California, États-Unis, 95403
- Kaiser Permanente-Santa Rosa
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Santa Rosa, California, États-Unis, 95403
- Sutter Pacific Medical Foundation
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South San Francisco, California, États-Unis, 94080
- Kaiser Permanente-South San Francisco
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Sunnyvale, California, États-Unis, 94086
- Palo Alto Medical Foundation-Sunnyvale
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Walnut Creek, California, États-Unis, 94596
- Kaiser Permanente-Walnut Creek
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Woodland Hills, California, États-Unis, 91367
- Kaiser Permanente-Woodland Hills
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Colorado
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Aurora, Colorado, États-Unis, 80012
- Rocky Mountain Cancer Centers-Aurora
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Aurora, Colorado, États-Unis, 80012
- The Medical Center of Aurora
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Boulder, Colorado, États-Unis, 80303
- Boulder Community Foothills Hospital
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Colorado Springs, Colorado, États-Unis, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, États-Unis, 80907
- Rocky Mountain Cancer Centers-Penrose
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Denver, Colorado, États-Unis, 80205
- Kaiser Permanente-Franklin
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Denver, Colorado, États-Unis, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, États-Unis, 80220
- Rose Medical Center
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Denver, Colorado, États-Unis, 80218
- Rocky Mountain Cancer Centers-Midtown
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Denver, Colorado, États-Unis, 80220
- Rocky Mountain Cancer Centers-Rose
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Denver, Colorado, États-Unis, 80218
- Colorado Blood Cancer Institute
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Denver, Colorado, États-Unis, 80222
- Western States Cancer Research NCORP
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Denver, Colorado, États-Unis, 80218
- Saint Joseph Hospital - Cancer Centers of Colorado
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Denver, Colorado, États-Unis, 80210
- AdventHealth Porter
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Durango, Colorado, États-Unis, 81301
- Mercy Medical Center
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Englewood, Colorado, États-Unis, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, États-Unis, 80113
- Swedish Medical Center
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Golden, Colorado, États-Unis, 80401
- Mountain Blue Cancer Care Center
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Greeley, Colorado, États-Unis, 80631
- Banner North Colorado Medical Center
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Greenwood Village, Colorado, États-Unis, 80111
- Rocky Mountain Cancer Centers-Greenwood Village
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Lafayette, Colorado, États-Unis, 80026
- Kaiser Permanente-Rock Creek
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Lakewood, Colorado, États-Unis, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Lakewood, Colorado, États-Unis, 80228
- CommonSpirit Saint Anthony Hospital Cancer Center
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Littleton, Colorado, États-Unis, 80120
- Rocky Mountain Cancer Centers-Littleton
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Littleton, Colorado, États-Unis, 80122
- AdventHealth Littleton
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Lone Tree, Colorado, États-Unis, 80124
- Sky Ridge Medical Center
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Lone Tree, Colorado, États-Unis, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
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Longmont, Colorado, États-Unis, 80501
- Longmont United Hospital
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Longmont, Colorado, États-Unis, 80501
- Rocky Mountain Cancer Centers-Longmont
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Loveland, Colorado, États-Unis, 80539
- Banner North Colorado Medical Center - Loveland Campus
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Parker, Colorado, États-Unis, 80138
- Rocky Mountain Cancer Centers-Parker
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Parker, Colorado, États-Unis, 80138
- AdventHealth Parker
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Pueblo, Colorado, États-Unis, 81004
- Saint Mary Corwin Medical Center
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Thornton, Colorado, États-Unis, 80260
- Rocky Mountain Cancer Centers-Thornton
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Wheat Ridge, Colorado, États-Unis, 80401
- Intermountain Health Lutheran Hospital
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Connecticut
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Hartford, Connecticut, États-Unis, 06105
- Smilow Cancer Hospital Care Center at Saint Francis
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New Britain, Connecticut, États-Unis, 06050
- The Hospital of Central Connecticut
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New Haven, Connecticut, États-Unis, 06520
- Yale University
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Delaware
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Dover, Delaware, États-Unis, 19901
- Bayhealth Hospital Kent Campus
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Lewes, Delaware, États-Unis, 19958
- Beebe Medical Center
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Newark, Delaware, États-Unis, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, États-Unis, 19713
- Delaware Clinical and Laboratory Physicians PA
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Newark, Delaware, États-Unis, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, États-Unis, 19718
- Christiana Care Health System-Christiana Hospital
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Rehoboth Beach, Delaware, États-Unis, 19971
- Beebe Health Campus
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Seaford, Delaware, États-Unis, 19973
- TidalHealth Nanticoke / Allen Cancer Center
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District of Columbia
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Washington D.C., District of Columbia, États-Unis, 20016
- Sibley Memorial Hospital
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Florida
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Lakeland, Florida, États-Unis, 33805
- The Watson Clinic
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Orlando, Florida, États-Unis, 32806
- Orlando Health Cancer Institute
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Georgia
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Atlanta, Georgia, États-Unis, 30322
- Emory University Hospital/Winship Cancer Institute
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Atlanta, Georgia, États-Unis, 30342
- Northside Hospital
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Decatur, Georgia, États-Unis, 30033
- Atlanta VA Medical Center
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Lawrenceville, Georgia, États-Unis, 30046
- Northside Hospital - Gwinnett
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Macon, Georgia, États-Unis, 31201
- Atrium Health Navicent
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Savannah, Georgia, États-Unis, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Hawaii
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Honolulu, Hawaii, États-Unis, 96817
- The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, États-Unis, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, États-Unis, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, États-Unis, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, États-Unis, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, États-Unis, 96819
- Kaiser Permanente Moanalua Medical Center
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Idaho
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Boise, Idaho, États-Unis, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Boise, Idaho, États-Unis, 83712
- Saint Luke's Cancer Institute - Boise
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Fruitland, Idaho, États-Unis, 83619
- Saint Luke's Cancer Institute - Fruitland
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Meridian, Idaho, États-Unis, 83642
- Saint Luke's Cancer Institute - Meridian
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Nampa, Idaho, États-Unis, 83687
- Saint Luke's Cancer Institute - Nampa
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Post Falls, Idaho, États-Unis, 83854
- Kootenai Clinic Cancer Services - Post Falls
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Twin Falls, Idaho, États-Unis, 83301
- Saint Luke's Cancer Institute - Twin Falls
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Illinois
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Bloomington, Illinois, États-Unis, 61704
- Illinois CancerCare-Bloomington
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Canton, Illinois, États-Unis, 61520
- Illinois CancerCare-Canton
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Carthage, Illinois, États-Unis, 62321
- Illinois CancerCare-Carthage
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Chicago, Illinois, États-Unis, 60611
- Northwestern University
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Chicago, Illinois, États-Unis, 60657
- UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital
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Chicago, Illinois, États-Unis, 60640
- Weiss Memorial Hospital
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Danville, Illinois, États-Unis, 61832
- Carle at The Riverfront
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Decatur, Illinois, États-Unis, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, États-Unis, 62526
- Cancer Care Specialists of Illinois - Decatur
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Decatur, Illinois, États-Unis, 62526
- Heartland Cancer Research NCORP
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Effingham, Illinois, États-Unis, 62401
- Crossroads Cancer Center
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Effingham, Illinois, États-Unis, 62401
- Carle Physician Group-Effingham
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Elk Grove Village, Illinois, États-Unis, 60007
- Ascension Alexian Brothers - Elk Grove Village
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Eureka, Illinois, États-Unis, 61530
- Illinois CancerCare-Eureka
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Galesburg, Illinois, États-Unis, 61401
- Illinois CancerCare-Galesburg
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Geneva, Illinois, États-Unis, 60134
- Northwestern Medicine Cancer Center Delnor
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Harvey, Illinois, États-Unis, 60426
- Ingalls Memorial Hospital
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Hinsdale, Illinois, États-Unis, 60521
- Hinsdale Hematology Oncology Associates Incorporated
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Joliet, Illinois, États-Unis, 60435
- Duly Health and Care Joliet
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Kewanee, Illinois, États-Unis, 61443
- Illinois CancerCare-Kewanee Clinic
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Macomb, Illinois, États-Unis, 61455
- Illinois CancerCare-Macomb
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Mattoon, Illinois, États-Unis, 61938
- Carle Physician Group-Mattoon/Charleston
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Moline, Illinois, États-Unis, 61265
- Trinity Medical Center
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Monmouth, Illinois, États-Unis, 61462
- Illinois CancerCare-Monmouth
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Niles, Illinois, États-Unis, 60714
- Illinois Cancer Specialists-Niles
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O'Fallon, Illinois, États-Unis, 62269
- Cancer Care Center of O'Fallon
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Ottawa, Illinois, États-Unis, 61350
- Illinois CancerCare-Ottawa Clinic
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Pekin, Illinois, États-Unis, 61554
- Illinois CancerCare-Pekin
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Peoria, Illinois, États-Unis, 61615
- Illinois CancerCare-Peoria
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Peru, Illinois, États-Unis, 61354
- Illinois CancerCare-Peru
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Princeton, Illinois, États-Unis, 61356
- Illinois CancerCare-Princeton
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River Forest, Illinois, États-Unis, 60305
- West Suburban Medical Center
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Rockford, Illinois, États-Unis, 61104
- Swedish American Hospital
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Rockford, Illinois, États-Unis, 61114
- UW Health Carbone Cancer Center Rockford
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Springfield, Illinois, États-Unis, 62702
- Southern Illinois University School of Medicine
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Springfield, Illinois, États-Unis, 62702
- Springfield Clinic
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Springfield, Illinois, États-Unis, 62702
- Central Illinois Hematology Oncology Center
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Springfield, Illinois, États-Unis, 62781
- Springfield Memorial Hospital
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Urbana, Illinois, États-Unis, 61801
- Carle Cancer Center
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Urbana, Illinois, États-Unis, 61801
- The Carle Foundation Hospital
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Warrenville, Illinois, États-Unis, 60555
- Northwestern Medicine Cancer Center Warrenville
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Indiana
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Elkhart, Indiana, États-Unis, 46515
- Elkhart General Hospital
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Elkhart, Indiana, États-Unis, 46514
- Michiana Hematology Oncology PC-Elkhart
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Elkhart, Indiana, États-Unis, 46514-2098
- Elkhart Clinic
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Indianapolis, Indiana, États-Unis, 46202
- Indiana University/Melvin and Bren Simon Cancer Center
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Indianapolis, Indiana, États-Unis, 46219
- IU Health Central Indiana Cancer Centers-East
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Kokomo, Indiana, États-Unis, 46904
- Community Howard Regional Health
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La Porte, Indiana, États-Unis, 46350
- IU Health La Porte Hospital
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Lafayette, Indiana, États-Unis, 47904
- IU Health Arnett Cancer Care
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Merrillville, Indiana, États-Unis, 46410
- Premier Oncology Hematology Associates
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Mishawaka, Indiana, États-Unis, 46545
- Michiana Hematology Oncology PC-Mishawaka
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Mishawaka, Indiana, États-Unis, 46545
- Saint Joseph Regional Medical Center-Mishawaka
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Muncie, Indiana, États-Unis, 47303
- IU Health Ball Memorial Hospital
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Plymouth, Indiana, États-Unis, 46563
- Michiana Hematology Oncology PC-Plymouth
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Richmond, Indiana, États-Unis, 47374
- Reid Health
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South Bend, Indiana, États-Unis, 46628
- Northern Indiana Cancer Research Consortium
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Westville, Indiana, États-Unis, 46391
- Michiana Hematology Oncology PC-Westville
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Iowa
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Ames, Iowa, États-Unis, 50010
- McFarland Clinic - Ames
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Cedar Rapids, Iowa, États-Unis, 52403
- Oncology Associates at Mercy Medical Center
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Clive, Iowa, États-Unis, 50325
- Mercy Cancer Center-West Lakes
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Clive, Iowa, États-Unis, 50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
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Des Moines, Iowa, États-Unis, 50314
- Mercy Medical Center - Des Moines
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Des Moines, Iowa, États-Unis, 50309
- Iowa-Wide Oncology Research Coalition NCORP
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Des Moines, Iowa, États-Unis, 50309
- UI Health Care Mission Cancer and Blood - Des Moines Clinic
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Des Moines, Iowa, États-Unis, 50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
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Mason City, Iowa, États-Unis, 50401
- Mercy Medical Center - North Iowa
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Ottumwa, Iowa, États-Unis, 52501
- Ottumwa Regional Health Center
-
Sioux City, Iowa, États-Unis, 51101
- Siouxland Regional Cancer Center
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Waterloo, Iowa, États-Unis, 50702
- MercyOne Waterloo Cancer Center
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West Des Moines, Iowa, États-Unis, 50266
- Mercy Medical Center-West Lakes
-
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Kansas
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Lawrence, Kansas, États-Unis, 66044
- Lawrence Memorial Hospital
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Prairie Village, Kansas, États-Unis, 66208
- Kansas City NCI Community Oncology Research Program
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Wichita, Kansas, États-Unis, 67214
- Wesley Medical Center
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Kentucky
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Bardstown, Kentucky, États-Unis, 40004
- CommonSpirit Saint Joseph Hospital - Bardstown
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Louisville, Kentucky, États-Unis, 40202
- Jewish Hospital
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Louisville, Kentucky, États-Unis, 40245
- UofL Health Medical Center Northeast
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Louisiana
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Baton Rouge, Louisiana, États-Unis, 70809
- Ochsner Health Center-Summa
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Kenner, Louisiana, États-Unis, 70065
- Ochsner Medical Center Kenner
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Monroe, Louisiana, États-Unis, 71202
- Ochsner LSU Health Monroe Medical Center
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New Orleans, Louisiana, États-Unis, 70121
- Ochsner Medical Center Jefferson
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Shreveport, Louisiana, États-Unis, 71103
- LSU Health Sciences Center at Shreveport
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Maine
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Augusta, Maine, États-Unis, 04330
- Harold Alfond Center for Cancer Care
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Bangor, Maine, États-Unis, 04401
- Eastern Maine Medical Center
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Brewer, Maine, États-Unis, 04412
- Lafayette Family Cancer Center-EMMC
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Maryland
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Baltimore, Maryland, États-Unis, 21287
- Johns Hopkins University/Sidney Kimmel Cancer Center
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Baltimore, Maryland, États-Unis, 21204
- Greater Baltimore Medical Center
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Elkton, Maryland, États-Unis, 21921
- Christiana Care - Union Hospital
-
Salisbury, Maryland, États-Unis, 21801
- TidalHealth Peninsula Regional
-
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Massachusetts
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Boston, Massachusetts, États-Unis, 02111
- Tufts Medical Center
-
Boston, Massachusetts, États-Unis, 02118
- Boston Medical Center
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Springfield, Massachusetts, États-Unis, 01199
- Baystate Medical Center
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Worcester, Massachusetts, États-Unis, 01655
- UMass Memorial Medical Center - University Campus
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Michigan
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Ann Arbor, Michigan, États-Unis, 48109
- University of Michigan Rogel Cancer Center
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Ann Arbor, Michigan, États-Unis, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
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Battle Creek, Michigan, États-Unis, 49017
- Bronson Battle Creek
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Dearborn, Michigan, États-Unis, 48124
- Corewell Health Dearborn Hospital
-
Detroit, Michigan, États-Unis, 48201
- Wayne State University/Karmanos Cancer Institute
-
Detroit, Michigan, États-Unis, 48236
- Henry Ford Health Saint John Hospital
-
Escanaba, Michigan, États-Unis, 49829
- OSF Saint Francis Hospital and Medical Group
-
Flint, Michigan, États-Unis, 48503
- Genesys Hurley Cancer Institute
-
Grand Rapids, Michigan, États-Unis, 49503
- Trinity Health Grand Rapids Hospital
-
Grand Rapids, Michigan, États-Unis, 49503
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital
-
Jackson, Michigan, États-Unis, 49201
- Allegiance Health
-
Kalamazoo, Michigan, États-Unis, 49007
- West Michigan Cancer Center
-
Livonia, Michigan, États-Unis, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Muskegon, Michigan, États-Unis, 49444
- Trinity Health Muskegon Hospital
-
Pontiac, Michigan, États-Unis, 48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Port Huron, Michigan, États-Unis, 48060
- Lake Huron Medical Center
-
Reed City, Michigan, États-Unis, 49677
- Corewell Health Reed City Hospital
-
Saginaw, Michigan, États-Unis, 48601
- MyMichigan Medical Center Saginaw
-
Saint Joseph, Michigan, États-Unis, 49085
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
-
Saint Joseph, Michigan, États-Unis, 49085
- Corewell Health Lakeland Hospitals - Saint Joseph Hospital
-
Traverse City, Michigan, États-Unis, 49684
- Munson Medical Center
-
Warren, Michigan, États-Unis, 48093
- Henry Ford Health Warren Hospital
-
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Minnesota
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Bemidji, Minnesota, États-Unis, 56601
- Sanford Joe Lueken Cancer Center
-
Burnsville, Minnesota, États-Unis, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, États-Unis, 55433
- Mercy Hospital
-
Duluth, Minnesota, États-Unis, 55805
- Saint Luke's Hospital of Duluth
-
Duluth, Minnesota, États-Unis, 55805
- Essentia Health Cancer Center
-
Edina, Minnesota, États-Unis, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, États-Unis, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fridley, Minnesota, États-Unis, 55432
- Unity Hospital
-
Hutchinson, Minnesota, États-Unis, 55350
- Hutchinson Area Health Care
-
Maplewood, Minnesota, États-Unis, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, États-Unis, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, États-Unis, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, États-Unis, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, États-Unis, 55454
- Health Partners Inc
-
Robbinsdale, Minnesota, États-Unis, 55422
- North Memorial Medical Health Center
-
Rochester, Minnesota, États-Unis, 55905
- Mayo Clinic in Rochester
-
Saint Cloud, Minnesota, États-Unis, 56303
- Coborn Cancer Center at Saint Cloud Hospital
-
Saint Louis Park, Minnesota, États-Unis, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Louis Park, Minnesota, États-Unis, 55416
- Metro Minnesota Community Oncology Research Consortium
-
Saint Paul, Minnesota, États-Unis, 55101
- Regions Hospital
-
Saint Paul, Minnesota, États-Unis, 55102
- United Hospital
-
Shakopee, Minnesota, États-Unis, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, États-Unis, 55082
- Lakeview Hospital
-
Waconia, Minnesota, États-Unis, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, États-Unis, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, États-Unis, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
-
Mississippi
-
Jackson, Mississippi, États-Unis, 39216
- University of Mississippi Medical Center
-
-
Missouri
-
Bolivar, Missouri, États-Unis, 65613
- Central Care Cancer Center - Bolivar
-
Cape Girardeau, Missouri, États-Unis, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, États-Unis, 63703
- Mercy Cancer Center - Cape Girardeau
-
Chesterfield, Missouri, États-Unis, 63017
- Saint Luke's Hospital
-
Jefferson City, Missouri, États-Unis, 65109
- MU Health Care Goldschmidt Cancer Center
-
Kansas City, Missouri, États-Unis, 64111
- Saint Luke's Hospital of Kansas City
-
Rolla, Missouri, États-Unis, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Rolla, Missouri, États-Unis, 65401
- Phelps Health Delbert Day Cancer Institute
-
Springfield, Missouri, États-Unis, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, États-Unis, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, États-Unis, 63131
- Missouri Baptist Medical Center
-
St Louis, Missouri, États-Unis, 63109
- Mercy Infusion Center - Chippewa
-
St Louis, Missouri, États-Unis, 63141
- Mercy Hospital Saint Louis
-
-
Montana
-
Billings, Montana, États-Unis, 59101
- Billings Clinic Cancer Center
-
Bozeman, Montana, États-Unis, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, États-Unis, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, États-Unis, 59405
- Benefis Sletten Cancer Institute
-
Kalispell, Montana, États-Unis, 59901
- Logan Health Medical Center
-
Missoula, Montana, États-Unis, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, États-Unis, 59804
- Community Medical Center
-
-
Nebraska
-
Grand Island, Nebraska, États-Unis, 68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Kearney, Nebraska, États-Unis, 68847
- CHI Health Good Samaritan
-
Lincoln, Nebraska, États-Unis, 68506
- Nebraska Hematology and Oncology
-
Lincoln, Nebraska, États-Unis, 68510
- Nebraska Cancer Research Center
-
Lincoln, Nebraska, États-Unis, 68516
- Cancer Partners of Nebraska
-
Omaha, Nebraska, États-Unis, 68198
- University of Nebraska Medical Center
-
-
Nevada
-
Henderson, Nevada, États-Unis, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, États-Unis, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, États-Unis, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, États-Unis, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, États-Unis, 89074
- Oncology Las Vegas - Henderson
-
Las Vegas, Nevada, États-Unis, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, États-Unis, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, États-Unis, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, États-Unis, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, États-Unis, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, États-Unis, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, États-Unis, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, États-Unis, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, États-Unis, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, États-Unis, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, États-Unis, 89121
- Cancer Therapy and Integrative Medicine
-
Las Vegas, Nevada, États-Unis, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, États-Unis, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, États-Unis, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, États-Unis, 89120
- Nevada Cancer Research Foundation NCORP
-
Las Vegas, Nevada, États-Unis, 89128
- Oncology Las Vegas - Tenaya
-
Las Vegas, Nevada, États-Unis, 89183
- OptumCare Cancer Care at Fort Apache
-
-
New Hampshire
-
Concord, New Hampshire, États-Unis, 03301
- New Hampshire Oncology Hematology PA-Concord
-
Dover, New Hampshire, États-Unis, 03820
- Wentworth-Douglass Hospital
-
Laconia, New Hampshire, États-Unis, 03246
- LRGHealthcare-Lakes Region General Hospital
-
Lebanon, New Hampshire, États-Unis, 03756
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
Manchester, New Hampshire, États-Unis, 03103
- Solinsky Center for Cancer Care
-
-
New Jersey
-
Camden, New Jersey, États-Unis, 08103
- Cooper Hospital University Medical Center
-
Englewood, New Jersey, États-Unis, 07631
- Englewood Hospital and Medical Center
-
Livingston, New Jersey, États-Unis, 07039
- Cooperman Barnabas Medical Center
-
Mount Holly, New Jersey, États-Unis, 08060
- Virtua Memorial
-
Mullica Hill, New Jersey, États-Unis, 08062
- Inspira Medical Center Mullica Hill
-
Paramus, New Jersey, États-Unis, 07652
- The Valley Hospital - Luckow Pavilion
-
Ridgewood, New Jersey, États-Unis, 07450
- Valley Health System Ridgewood Campus
-
Vineland, New Jersey, États-Unis, 08360
- Inspira Medical Center Vineland
-
Westwood, New Jersey, États-Unis, 07675
- Valley Health System-Hematology/Oncology
-
-
New Mexico
-
Albuquerque, New Mexico, États-Unis, 87106
- University of New Mexico Cancer Center
-
Albuquerque, New Mexico, États-Unis, 87110
- Presbyterian Kaseman Hospital
-
Las Cruces, New Mexico, États-Unis, 88011
- Memorial Medical Center-Las Cruces
-
Santa Fe, New Mexico, États-Unis, 87505
- Christus Saint Vincent Regional Cancer Center
-
-
New York
-
Brooklyn, New York, États-Unis, 11203
- Kings County Hospital
-
Brooklyn, New York, États-Unis, 11203
- State University of New York Downstate Medical Center
-
Buffalo, New York, États-Unis, 14263
- Roswell Park Cancer Institute
-
East Syracuse, New York, États-Unis, 13057
- Hematology Oncology Associates of Central New York-East Syracuse
-
New York, New York, États-Unis, 10032
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
-
New York, New York, États-Unis, 10016
- Laura and Isaac Perlmutter Cancer Center at NYU Langone
-
Plattsburgh, New York, États-Unis, 12901
- Champlain Valley Physicians Hospital Medical Center
-
Rochester, New York, États-Unis, 14642
- University of Rochester
-
Syracuse, New York, États-Unis, 13210
- State University of New York Upstate Medical University
-
The Bronx, New York, États-Unis, 10461
- Montefiore Medical Center-Einstein Campus
-
The Bronx, New York, États-Unis, 10467
- Montefiore Medical Center - Moses Campus
-
The Bronx, New York, États-Unis, 10461
- Montefiore Medical Center-Weiler Hospital
-
-
North Carolina
-
Asheboro, North Carolina, États-Unis, 27203
- Randolph Hospital
-
Chapel Hill, North Carolina, États-Unis, 27599
- UNC Lineberger Comprehensive Cancer Center
-
Clinton, North Carolina, États-Unis, 28328
- Southeastern Medical Oncology Center-Clinton
-
Goldsboro, North Carolina, États-Unis, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, États-Unis, 27534
- Wayne Memorial Hospital
-
Greensboro, North Carolina, États-Unis, 27403
- Cone Health Cancer Center
-
Hendersonville, North Carolina, États-Unis, 28791
- Margaret R Pardee Memorial Hospital
-
Jacksonville, North Carolina, États-Unis, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Kinston, North Carolina, États-Unis, 28501
- ECU Health Oncology Kinston
-
Reidsville, North Carolina, États-Unis, 27320
- Annie Penn Memorial Hospital
-
Statesville, North Carolina, États-Unis, 28677
- Iredell Memorial Hospital
-
Washington, North Carolina, États-Unis, 27889
- Marion L Shepard Cancer Center - ECU Health Beaufort Hospital
-
Winston-Salem, North Carolina, États-Unis, 27157
- Wake Forest University Health Sciences
-
-
North Dakota
-
Bismarck, North Dakota, États-Unis, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, États-Unis, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, États-Unis, 58122
- Sanford Broadway Medical Center
-
-
Ohio
-
Akron, Ohio, États-Unis, 44307
- Cleveland Clinic Akron General
-
Akron, Ohio, États-Unis, 44304
- Summa Health System - Akron Campus
-
Barberton, Ohio, États-Unis, 44203
- Summa Health System - Barberton Campus
-
Canton, Ohio, États-Unis, 44708
- Cleveland Clinic Mercy Hospital
-
Chardon, Ohio, États-Unis, 44024
- Geauga Hospital
-
Cincinnati, Ohio, États-Unis, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati, Ohio, États-Unis, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, États-Unis, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, États-Unis, 45255
- TriHealth Cancer Institute-Anderson
-
Cleveland, Ohio, États-Unis, 44106
- Case Western Reserve University
-
Cleveland, Ohio, États-Unis, 44109
- MetroHealth Medical Center
-
Columbus, Ohio, États-Unis, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, États-Unis, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, États-Unis, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, États-Unis, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, États-Unis, 43222
- Mount Carmel Health Center West
-
Columbus, Ohio, États-Unis, 43215
- Columbus NCI Community Oncology Research Program
-
Dayton, Ohio, États-Unis, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, États-Unis, 45409
- Miami Valley Hospital
-
Dayton, Ohio, États-Unis, 45415
- Miami Valley Hospital North
-
Elyria, Ohio, États-Unis, 44035
- Mercy Cancer Center-Elyria
-
Findlay, Ohio, États-Unis, 45840
- Blanchard Valley Hospital
-
Lima, Ohio, États-Unis, 45801
- Saint Rita's Medical Center
-
Marietta, Ohio, États-Unis, 45750
- Marietta Memorial Hospital
-
Maumee, Ohio, États-Unis, 43537
- Toledo Clinic Cancer Centers-Maumee
-
Mayfield Heights, Ohio, États-Unis, 44124
- UH Seidman Cancer Center at Landerbrook Health Center
-
Mentor, Ohio, États-Unis, 44060
- UH Seidman Cancer Center at Lake Health Mentor Campus
-
Newark, Ohio, États-Unis, 43055
- Licking Memorial Hospital
-
Sandusky, Ohio, États-Unis, 44870
- UH Seidman Cancer Center at Firelands Regional Medical Center
-
Springfield, Ohio, États-Unis, 45504
- Springfield Regional Cancer Center
-
Springfield, Ohio, États-Unis, 45504
- Springfield Regional Medical Center
-
Sylvania, Ohio, États-Unis, 43560
- ProMedica Flower Hospital
-
Toledo, Ohio, États-Unis, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Toledo, Ohio, États-Unis, 43614
- University of Toledo
-
Westerville, Ohio, États-Unis, 43081
- Saint Ann's Hospital
-
Westlake, Ohio, États-Unis, 44145
- UH Seidman Cancer Center at Saint John Medical Center
-
-
Oklahoma
-
Oklahoma City, Oklahoma, États-Unis, 73104
- University of Oklahoma Health Sciences Center
-
Tulsa, Oklahoma, États-Unis, 74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
-
Oregon
-
Clackamas, Oregon, États-Unis, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, États-Unis, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, États-Unis, 97420
- Bay Area Hospital
-
Newberg, Oregon, États-Unis, 97132
- Providence Newberg Medical Center
-
Oregon City, Oregon, États-Unis, 97045
- Providence Willamette Falls Medical Center
-
Portland, Oregon, États-Unis, 97213
- Providence Portland Medical Center
-
Portland, Oregon, États-Unis, 97225
- Providence Saint Vincent Medical Center
-
-
Pennsylvania
-
Allentown, Pennsylvania, États-Unis, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, États-Unis, 18015
- Saint Luke's University Hospital-Bethlehem Campus
-
Bryn Mawr, Pennsylvania, États-Unis, 19010
- Bryn Mawr Hospital
-
Danville, Pennsylvania, États-Unis, 17822
- Geisinger Medical Center
-
Doylestown, Pennsylvania, États-Unis, 18901
- Doylestown Hospital
-
Drexel Hill, Pennsylvania, États-Unis, 19026
- Delaware County Memorial Hospital
-
Ephrata, Pennsylvania, États-Unis, 17522
- Ephrata Cancer Center
-
Ephrata, Pennsylvania, États-Unis, 17522
- Ephrata Community Hospital
-
Gettysburg, Pennsylvania, États-Unis, 17325
- Adams Cancer Center
-
Hanover, Pennsylvania, États-Unis, 17331
- WellSpan Medical Oncology and Hematology
-
Hazleton, Pennsylvania, États-Unis, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hershey, Pennsylvania, États-Unis, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Lewisburg, Pennsylvania, États-Unis, 17837
- Geisinger Medical Oncology-Lewisburg
-
Paoli, Pennsylvania, États-Unis, 19301
- Paoli Memorial Hospital
-
Philadelphia, Pennsylvania, États-Unis, 19111
- Fox Chase Cancer Center
-
Philadelphia, Pennsylvania, États-Unis, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, États-Unis, 19140
- Temple University Hospital
-
Pottstown, Pennsylvania, États-Unis, 19464
- Pottstown Hospital
-
Pottsville, Pennsylvania, États-Unis, 17901
- Geisinger Cancer Services-Pottsville
-
Scranton, Pennsylvania, États-Unis, 18508
- Hematology and Oncology Associates of North East Pennsylvania
-
Selinsgrove, Pennsylvania, États-Unis, 17870
- Geisinger Medical Oncology-Selinsgrove
-
Sellersville, Pennsylvania, États-Unis, 18960
- Grand View Hospital
-
State College, Pennsylvania, États-Unis, 16803
- Mount Nittany Medical Center
-
West Chester, Pennsylvania, États-Unis, 19380
- Chester County Hospital
-
West Reading, Pennsylvania, États-Unis, 19611
- Reading Hospital
-
Wilkes-Barre, Pennsylvania, États-Unis, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Wynnewood, Pennsylvania, États-Unis, 19096
- Lankenau Medical Center
-
York, Pennsylvania, États-Unis, 17403
- WellSpan Health-York Hospital
-
-
South Carolina
-
Boiling Springs, South Carolina, États-Unis, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Easley, South Carolina, États-Unis, 29640
- Prisma Health Cancer Institute - Easley
-
Greenville, South Carolina, États-Unis, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, États-Unis, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, États-Unis, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, États-Unis, 29605
- Prisma Health Greenville Memorial Hospital
-
Greenville, South Carolina, États-Unis, 29601
- Greenville Health System Cancer Institute-Andrews
-
Greer, South Carolina, États-Unis, 29650
- Prisma Health Cancer Institute - Greer
-
Seneca, South Carolina, États-Unis, 29672
- Prisma Health Cancer Institute - Seneca
-
-
South Dakota
-
Rapid City, South Dakota, États-Unis, 57701
- Rapid City Regional Hospital
-
Sioux Falls, South Dakota, États-Unis, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, États-Unis, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, États-Unis, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Nashville, Tennessee, États-Unis, 37232
- Vanderbilt University/Ingram Cancer Center
-
-
Texas
-
Austin, Texas, États-Unis, 78701
- Dell Seton Medical Center at The University of Texas
-
Dallas, Texas, États-Unis, 75235
- Parkland Memorial Hospital
-
Dallas, Texas, États-Unis, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
Fort Sam Houston, Texas, États-Unis, 78234
- Brooke Army Medical Center
-
Lubbock, Texas, États-Unis, 79410
- Covenant Medical Center-Lakeside
-
Lubbock, Texas, États-Unis, 79430
- Texas Tech University Health Sciences Center-Lubbock
-
San Antonio, Texas, États-Unis, 78229
- University of Texas Health Science Center at San Antonio
-
-
Utah
-
Salt Lake City, Utah, États-Unis, 84112
- Huntsman Cancer Institute/University of Utah
-
-
Virginia
-
Charlottesville, Virginia, États-Unis, 22908
- University of Virginia Cancer Center
-
Fishersville, Virginia, États-Unis, 22939
- Augusta Health Center for Cancer and Blood Disorders
-
Martinsville, Virginia, États-Unis, 24112
- Sovah Health Martinsville
-
-
Washington
-
Edmonds, Washington, États-Unis, 98026
- Swedish Cancer Institute-Edmonds
-
Longview, Washington, États-Unis, 98632
- PeaceHealth Saint John Medical Center
-
Seattle, Washington, États-Unis, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, États-Unis, 98122
- Swedish Medical Center-First Hill
-
Vancouver, Washington, États-Unis, 98664
- PeaceHealth Southwest Medical Center
-
-
West Virginia
-
Charleston, West Virginia, États-Unis, 25304
- Vandalia Health/CAMC Institute for Academic Medicine
-
-
Wisconsin
-
Antigo, Wisconsin, États-Unis, 54409
- Aspirus Cancer Care-Antigo-Volm Cancer Center
-
Appleton, Wisconsin, États-Unis, 54911
- ThedaCare Regional Cancer Center
-
Burlington, Wisconsin, États-Unis, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Eau Claire, Wisconsin, États-Unis, 54701
- HSHS Sacred Heart Hospital
-
Eau Claire, Wisconsin, États-Unis, 54701
- Marshfield Clinic Cancer Center at Sacred Heart
-
Germantown, Wisconsin, États-Unis, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, États-Unis, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, États-Unis, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, États-Unis, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, États-Unis, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Green Bay, Wisconsin, États-Unis, 54301
- Bellin Memorial Hospital
-
Green Bay, Wisconsin, États-Unis, 54301-3526
- Green Bay Oncology at Saint Vincent Hospital
-
Johnson Creek, Wisconsin, États-Unis, 53038
- University of Wisconsin Carbone Cancer Center - Johnson Creek
-
Kenosha, Wisconsin, États-Unis, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, États-Unis, 54601
- Gundersen Lutheran Medical Center
-
Madison, Wisconsin, États-Unis, 53792
- University of Wisconsin Carbone Cancer Center - University Hospital
-
Madison, Wisconsin, États-Unis, 53715
- SSM Health Dean Medical Group - South Madison Campus
-
Manitowoc, Wisconsin, États-Unis, 54221
- Holy Family Memorial Hospital
-
Marinette, Wisconsin, États-Unis, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marinette, Wisconsin, États-Unis, 54143
- Bay Area Medical Center
-
Marshfield, Wisconsin, États-Unis, 54449
- Marshfield Medical Center-Marshfield
-
Marshfield, Wisconsin, États-Unis, 54449
- Marshfield Medical Center
-
Milwaukee, Wisconsin, États-Unis, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, États-Unis, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, États-Unis, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, États-Unis, 53233
- Aurora Sinai Medical Center
-
Minocqua, Wisconsin, États-Unis, 54548
- Marshfield Medical Center - Minocqua
-
New Richmond, Wisconsin, États-Unis, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, États-Unis, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oconto Falls, Wisconsin, États-Unis, 54154
- Saint Vincent Hospital Cancer Center at Oconto Falls
-
Oshkosh, Wisconsin, États-Unis, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, États-Unis, 53406
- Aurora Cancer Care-Racine
-
Rhinelander, Wisconsin, États-Unis, 54501
- Saint Mary's Hospital
-
Rhinelander, Wisconsin, États-Unis, 54501
- Aspirus Cancer Care-Rhinelander-James Beck Cancer Center
-
Rice Lake, Wisconsin, États-Unis, 54868
- Marshfield Medical Center-Rice Lake
-
Rice Lake, Wisconsin, États-Unis, 54868
- Lakeview Medical Center-Marshfield Clinic
-
Sheboygan, Wisconsin, États-Unis, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Stevens Point, Wisconsin, États-Unis, 54481
- Aspirus Cancer Care - Stevens Point
-
Summit, Wisconsin, États-Unis, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, États-Unis, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, États-Unis, 53188
- UW Cancer Center at ProHealth Care
-
Waukesha, Wisconsin, États-Unis, 53188
- ProHealth Waukesha Memorial Hospital
-
Waukesha, Wisconsin, États-Unis, 53188
- Aurora Cancer Care-Waukesha
-
Wausau, Wisconsin, États-Unis, 54401
- Marshfield Clinic-Wausau Center
-
Wausau, Wisconsin, États-Unis, 54401
- Aspirus Cancer Care-Wausau
-
Wauwatosa, Wisconsin, États-Unis, 53226
- Aurora Cancer Care-Milwaukee West
-
West Allis, Wisconsin, États-Unis, 53227
- Aurora West Allis Medical Center
-
Weston, Wisconsin, États-Unis, 54476
- Marshfield Medical Center - Weston
-
Wisconsin Rapids, Wisconsin, États-Unis, 54494
- Aspirus Cancer Care - Wisconsin Rapids
-
Wisconsin Rapids, Wisconsin, États-Unis, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
-
Critères de participation
Les chercheurs recherchent des personnes qui correspondent à une certaine description, appelée critères d'éligibilité. Certains exemples de ces critères sont l'état de santé général d'une personne ou des traitements antérieurs.
Critère d'éligibilité
Âges éligibles pour étudier
18 ans et plus (Adulte, Adulte plus âgé)
Accepte les volontaires sains
Non
Sexes éligibles pour l'étude
Tout
La description
Inclusion Criteria:
- PRE-REGISTRATION (STEP 0)
- Histologically confirmed DLBCL expressing CD20 antigen; patients with transformed lymphoma are excluded; in this regard, patients with composite lymphoma in the diagnostic tissue (concomitant DLBCL and follicular or other low-grade lymphoma component) are excluded; however, patients with DLBCL in primary diagnostic tissue but a bone marrow that shows low grade or indeterminate lymphoma are eligible; patients with known primary mediastinal large B-cell lymphoma (PMLBCL) are excluded; similarly, patients with known c-myc translocation (by fluorescence in situ hybridization) positive DLBCL are encouraged to participate in trials specifically designed for these patients; however patients with known c-myc DLBC positive are NOT excluded from this study; c-myc testing prior to study enrollment is NOT required
- Stages II bulky disease (defined as mass size of more than 10 cm), stage III, or IV (Ann Arbor staging); patients with stage I and stage II non-bulky disease are excluded from this study
- A paraffin-embedded tumor tissue specimen from the initial diagnostic biopsy has been located and ready to ship to the Mayo Clinic Lymphoma Laboratory following pre-registration; Note: excisional tumor biopsy is preferred; core needle biopsies will be considered adequate if there is enough tissue for the mandatory central pathology review immunohistochemistry and Genomics Education Partnership (GEP); submission of a tumor block is preferred, but if unavailable submit alternative materials
- Eastern Cooperative Oncology Group (ECOG) performance status 0-2
- Previously untreated and not receiving any other agent that would be considered as a treatment for the lymphoma; for subjects with severe systemic symptoms, compressive disease, or rapidly progressing symptomatic adenopathy, are allowed for lymphoma associated symptom treatment with up to 1 mg/kg/day prednisone, or equivalent, for a maximum of 7 days is permitted prior to beginning the treatment, at the discretion of the investigator; a washout period does not apply
- No known central nervous system (CNS) lymphoma or cerebrospinal fluid involvement with malignant lymphoma cells; these patients are usually treated with CNS directed therapy; screening for cerebrospinal fluid (CSF)/CNS involvement is NOT required but can be performed per treating medical doctor (MD) discretion; intrathecal (IT) methotrexate or IT cytarabine prophylaxis in patients with negative CSF who are felt to be at high risk of CNS relapse is allowed per local MD discretion; this should be noted on the treatment form
- Absence of history of myocardial infarction =< 6 months, or congestive heart failure requiring use of ongoing maintenance therapy for life-threatening ventricular arrhythmias
- Absence of history of deep venous thrombosis/embolism, threatening thromboembolism or known thrombophilia; patients with a history of deep vein thrombosis(DVT)/pulmonary embolism (PE) or thrombophilia may participate if they are willing to be on full anticoagulation during the treatment if randomized to rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone (R2CHOP) arm A; full anticoagulation is defined as warfarin, factor X inhibitors, or low molecular weight heparin at therapeutic doses
- Patient must be able and willing to receive anticoagulation therapy with aspirin 70-325 mg daily prophylaxis, low molecular weight heparin, factor X inhibitors or warfarin; patients unable or unwilling to take any prophylaxis are NOT eligible
- Absence of history of acquired immune deficiency syndrome (AIDS)-related conditions (other than the presenting DLBCL) or post-transplant lymphoproliferative disorder (PTLD) in immunocompromised patients; patients with human immunodeficiency virus (HIV) on antiretroviral therapy other than zidovudine (AZT) and/or stavudine and without prior AIDS defining conditions and adequate CD4 count (> 400) are eligible
- No other active malignancy requiring therapy such as radiation, chemotherapy, or immunotherapy; exceptions to this are as follows: localized non-melanotic skin cancer and any cancer that in the judgment of the investigator has been treated with curative intent and will not interfere with the study treatment plan and response assessment
- No history of radiation therapy to >= 25% of the bone marrow for other diseases or history of anthracycline therapy
- Patients must not be receiving erythroid stimulating agents (EPO: Procrit, Aranesp)
- RANDOMIZATION (STEP 1)
- Patient meets the eligibility criteria outlined above
- Site has received notification from Mayo Clinic - Rochester Division of Hematopathology of the central confirmation of diagnosis and tissue adequacy for mandatory research studies
- Patients must have measurable disease (at least 1 lesion of >= 1.5 cm in one diameter) as detected by computed tomography (CT) or the CT images of the positron emission tomography (PET)/CT
- International Prognostic Index (IPI) of 2 or greater
- Ejection fraction of >= 45% by either multi-gated acquisition (MUGA) scan or echocardiogram (ECHO)
- Absence of co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens, including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
- Absolute neutrophil count (ANC) >= 1500
- Platelets (PLT) >= 100,000
- Total bilirubin =< 1.5 x upper limit of normal (ULN) or if total bilirubin is > 1.5 x ULN, the direct bilirubin must be normal
- Alkaline (Alk.) phosphatase =< 3 x ULN unless evidence of the direct liver involvement by lymphoma - then =< 5 x ULN
- Aspartate aminotransferase (AST) =< 3 x ULN unless evidence of the direct liver involvement by lymphoma - then =< 5 x ULN
- Creatinine =< 2 x ULN or creatinine clearance (CrCl) > 30 ml/min
- Women must not be pregnant or breast-feeding
- Females of childbearing potential (FCBP) must have a negative serum or urine pregnancy test with a sensitivity of at least 25 mIU/mL within 10-14 days prior to and again within 24 hours of starting lenalidomide and must either commit to continued abstinence from heterosexual intercourse or begin TWO acceptable methods of birth control, one highly effective method and one additional effective method AT THE SAME TIME, at least 28 days before she starts taking lenalidomide; FCBP must also agree to ongoing pregnancy testing; a female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
- Men must agree to use a latex condom during sexual contact with a FCBP even if they have had a successful vasectomy; all patients must be counseled at a minimum of every 28 days about pregnancy precautions and risks of fetal exposure
Plan d'étude
Cette section fournit des détails sur le plan d'étude, y compris la façon dont l'étude est conçue et ce que l'étude mesure.
Comment l'étude est-elle conçue ?
Détails de conception
- Objectif principal: Traitement
- Répartition: Randomisé
- Modèle interventionnel: Affectation parallèle
- Masquage: Aucun (étiquette ouverte)
Armes et Interventions
Groupe de participants / Bras |
Intervention / Traitement |
|---|---|
|
Expérimental: Arm A (rituximab, combination chemotherapy, lenalidomide)
Patients receive rituximab IV, cyclophosphamide IV, doxorubicin hydrochloride IV, and vincristine sulfate IV on day 1; prednisone PO on days 1-5; and lenalidomide PO on days 1-10. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity. |
Correlative studies Given IV
Autres noms:
Given IV
Autres noms:
Given PO
Autres noms:
Given PO
Autres noms:
Given IV
Autres noms:
Given IV
Autres noms:
|
|
Comparateur actif: Arm B (rituximab, combination chemotherapy)
Patients receive rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone as in Arm A. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity. |
Correlative studies Given IV
Autres noms:
Given IV
Autres noms:
Given PO
Autres noms:
Given IV
Autres noms:
Given IV
Autres noms:
|
Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
3-year Progression-free Survival Rate
Délai: Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10, 3-year PFS rate reported
|
Progression-free survival is defined as the time from randomization to disease progression, new primary of the same type or death, whichever occurs first. Progressive disease is defined as:
|
Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10, 3-year PFS rate reported
|
Mesures de résultats secondaires
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
Proportion of Patients With Response
Délai: Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10
|
Response is defined as complete response (CR) or partial response (PR) CR: Complete disappearance of all detectable clinical evidence of disease and disease-related symptoms PR:
|
Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10
|
|
Proportion of Patients With Complete Response
Délai: Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10
|
Complete response is defined as complete disappearance of all detectable clinical evidence of disease, and disease-related symptoms if present prior to therapy. |
Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10
|
|
Overall Survival Rate at 3 Years
Délai: Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10
|
Overall survival is defined as time from randomization to death or date last known alive. Overall survival rate at 3 years was calculated using the method of Kaplan Meier. |
Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10
|
Autres mesures de résultats
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
Impact du sous-type moléculaire DLBCL sur les résultats.
Délai: Évalué au départ, tous les 3 mois pendant 2 ans, tous les 6 mois pendant la 3e année, puis annuellement pendant les années 4 à 10
|
Évalué au départ, tous les 3 mois pendant 2 ans, tous les 6 mois pendant la 3e année, puis annuellement pendant les années 4 à 10
|
|
|
Interim PET Scan Results in Relation to Treatment Outcome
Délai: Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10
|
|
Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10
|
Collaborateurs et enquêteurs
C'est ici que vous trouverez les personnes et les organisations impliquées dans cette étude.
Parrainer
Les enquêteurs
- Chercheur principal: Grzegorz S Nowakowski, ECOG-ACRIN Cancer Research Group
Publications et liens utiles
La personne responsable de la saisie des informations sur l'étude fournit volontairement ces publications. Il peut s'agir de tout ce qui concerne l'étude.
Dates d'enregistrement des études
Ces dates suivent la progression des dossiers d'étude et des soumissions de résultats sommaires à ClinicalTrials.gov. Les dossiers d'étude et les résultats rapportés sont examinés par la Bibliothèque nationale de médecine (NLM) pour s'assurer qu'ils répondent à des normes de contrôle de qualité spécifiques avant d'être publiés sur le site Web public.
Dates principales de l'étude
Début de l'étude (Réel)
27 août 2013
Achèvement primaire (Réel)
26 mars 2020
Achèvement de l'étude (Estimé)
31 décembre 2026
Dates d'inscription aux études
Première soumission
14 mai 2013
Première soumission répondant aux critères de contrôle qualité
14 mai 2013
Première publication (Estimé)
17 mai 2013
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Réel)
27 octobre 2026
Dernière mise à jour soumise répondant aux critères de contrôle qualité
24 octobre 2026
Dernière vérification
1 octobre 2026
Plus d'information
Termes liés à cette étude
Termes MeSH pertinents supplémentaires
- Acides aminés, peptides et protéines
- Protéines
- Produits chimiques organiques
- Composés hétérocycliques, 1 anneau
- Composés hétérocycliques
- Composés hétérocycliques, 2 anneaux
- Composés hétérocycliques, anneau fusionné
- Hydrocarbures
- Hydrocarbures, cyclique
- Glucides
- Acides carboxyliques
- Alcaloïdes
- Hydrocarbures aromatiques polycycliques
- Hydrocarbures, aromatique
- Composés polycycliques
- Glycosides
- Pipéridines
- Indoles
- Anticorps, monoclonal
- Anticorps
- Immunoglobulines
- Immunoprotéines
- Protéines sanguines
- Globulines sériques
- Globulines
- Prégnades
- Grossesse
- Stéroïdes
- Composés à anneau fusionné
- Moutards phosphoramides
- Composés de moutarde d'azote
- Composés moutarde
- Hydrocarbures, halogénés
- Phosphoramides
- Composés organophosphores
- Grossissements
- Alcaloïdes Vinca
- Alcaloïdes de la secologane tryptamine
- Alcaloïdes indole
- Indolizidines
- Indolizines
- Anthracyclines
- Naphtacènes
- Aminoglycosides
- Anticorps, monoclonal et murin
- Daunorubicine
- Phtalimides
- Acides phtaliques
- Acides, carbocyclique
- Pipéridones
- Isoindoles
- Lénalidomide
- Rituximab
- Prednisone
- Cyclophosphamide
- Doxorubicine
- Vincristine
- Ct-p10
- deltacortene
- prednylidene
Autres numéros d'identification d'étude
- NCI-2013-00959
- U10CA180820 (Subvention/contrat des NIH des États-Unis)
- U24CA196172 (Subvention/contrat des NIH des États-Unis)
- U10CA021115 (Subvention/contrat des NIH des États-Unis)
- NCI-2013-00959 (Identificateur de registre: CTRP (Clinical Trial Reporting Program))
- ECOG-E1412
- S13-01316
- E1412 (Autre identifiant: CTEP)
- E1412
- E1412 (Autre identifiant: ECOG-ACRIN Cancer Research Group)
Ces informations ont été extraites directement du site Web clinicaltrials.gov sans aucune modification. Si vous avez des demandes de modification, de suppression ou de mise à jour des détails de votre étude, veuillez contacter register@clinicaltrials.gov. Dès qu'un changement est mis en œuvre sur clinicaltrials.gov, il sera également mis à jour automatiquement sur notre site Web .