Rituximab och kombinationskemoterapi med eller utan lenalidomid vid behandling av patienter med nyligen diagnostiserat stadium II-IV diffust storcelligt B-lymfom
24 oktober 2026 uppdaterad av: National Cancer Institute (NCI)
Randomiserad öppen fas II-studie av lenalidomid R-CHOP (R2CHOP) vs. RCHOP (Rituximab, cyklofosfamid, doxorubicin, vinkristin och prednison) hos patienter med nyligen diagnostiserat diffust stort B-cellslymfom
This randomized phase II trial studies how well rituximab and combination chemotherapy with or without lenalidomide work in treating patients with newly diagnosed stage II-IV diffuse large B cell lymphoma. Monoclonal antibodies, such as rituximab, may interfere with the ability of cancer cells to grow and spread. Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Lenalidomide may stimulate the immune system in different ways and stop cancer cells from growing. It is not yet known whether rituximab and combination chemotherapy are more effective when given with or without lenalidomide in treating patients with diffuse large B cell lymphoma.
Studieöversikt
Status
Aktiv, inte rekryterande
Betingelser
Detaljerad beskrivning
PRIMARY OBJECTIVES:
I. Progression-free survival (PFS).
SECONDARY OBJECTIVES:
I. Response rate (RR). II. Complete remission (CR) rate as defined by positron emission tomography (PET)-computed tomography (CT) criteria.
III. Overall survival (OS).
TERTIARY OBJECTIVES:
I. Impact of diffuse large B cell lymphoma (DLBCL) molecular subtype on outcome.
II. Interim PET scan results in relation to treatment outcome.
OUTLINE: Patients are randomized to 1 of 2 treatment arms.
ARM A: Patients receive rituximab intravenously (IV), cyclophosphamide IV, doxorubicin hydrochloride IV, and vincristine sulfate IV on day 1; prednisone orally (PO) on days 1-5; and lenalidomide PO on days 1-10. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity.
ARM B: Patients receive rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone as in Arm A. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 3 months for 2 years, every 6 months for 1 year, and then annually for up to 7 years.
Studietyp
Interventionell
Inskrivning (Faktisk)
349
Fas
- Fas 2
Kontakter och platser
Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.
Studieorter
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Alaska
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Anchorage, Alaska, Förenta staterna, 99508
- Alaska Breast Care and Surgery LLC
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Anchorage, Alaska, Förenta staterna, 99508
- Alaska Women's Cancer Care
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Anchorage, Alaska, Förenta staterna, 99508
- Anchorage Oncology Centre
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Anchorage, Alaska, Förenta staterna, 99508
- Katmai Oncology Group
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Anchorage, Alaska, Förenta staterna, 99508
- Providence Alaska Medical Center
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Arizona
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Scottsdale, Arizona, Förenta staterna, 85259
- Mayo Clinic in Arizona
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Tucson, Arizona, Förenta staterna, 85719
- Banner University Medical Center - Tucson
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Tucson, Arizona, Förenta staterna, 85719
- University of Arizona Cancer Center-North Campus
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Arkansas
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Little Rock, Arkansas, Förenta staterna, 72205
- John L McClellan Memorial Veterans Hospital
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California
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Antioch, California, Förenta staterna, 94531
- Kaiser Permanente-Deer Valley Medical Center
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Auburn, California, Förenta staterna, 95602
- Sutter Auburn Faith Hospital
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Baldwin Park, California, Förenta staterna, 91706
- Kaiser Permanente-Baldwin Park
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Bellflower, California, Förenta staterna, 90706
- Kaiser Permanente-Bellflower
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Burbank, California, Förenta staterna, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Harbor City, California, Förenta staterna, 90710
- Kaiser Permanente South Bay
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Irvine, California, Förenta staterna, 92618
- Kaiser Permanente-Irvine
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Loma Linda, California, Förenta staterna, 92354
- Loma Linda University Medical Center
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Modesto, California, Förenta staterna, 95355
- Memorial Medical Center
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Mountain View, California, Förenta staterna, 94040
- Palo Alto Medical Foundation-Camino Division
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Mountain View, California, Förenta staterna, 94040
- Palo Alto Medical Foundation-Gynecologic Oncology
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Oakland, California, Förenta staterna, 94611
- Kaiser Permanente-Oakland
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Orange, California, Förenta staterna, 92868
- UC Irvine Health/Chao Family Comprehensive Cancer Center
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Palo Alto, California, Förenta staterna, 94304
- Stanford Cancer Institute Palo Alto
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Palo Alto, California, Förenta staterna, 94301
- Palo Alto Medical Foundation Health Care
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Panorama City, California, Förenta staterna, 91402
- Kaiser Permanente - Panorama City
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Richmond, California, Förenta staterna, 94801
- Kaiser Permanente-Richmond
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Sacramento, California, Förenta staterna, 95816
- Sutter Medical Center Sacramento
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Sacramento, California, Förenta staterna, 95823
- Kaiser Permanente-South Sacramento
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Sacramento, California, Förenta staterna, 95825
- Kaiser Permanente Sacramento Medical Center
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San Diego, California, Förenta staterna, 92120
- Kaiser Permanente-San Diego Zion
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San Diego, California, Förenta staterna, 92108
- Kaiser Permanente-Rio San Diego
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San Francisco, California, Förenta staterna, 94115
- Kaiser Permanente-San Francisco
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San Francisco, California, Förenta staterna, 94115
- California Pacific Medical Center-Pacific Campus
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San Jose, California, Förenta staterna, 95119
- Kaiser Permanente-Santa Teresa-San Jose
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San Jose, California, Förenta staterna, 95124
- Stanford Cancer Center South Bay
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San Marcos, California, Förenta staterna, 92078
- Kaiser Permanente-San Marcos
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San Rafael, California, Förenta staterna, 94903
- Kaiser Permanente-San Rafael
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Santa Clara, California, Förenta staterna, 95051
- Kaiser Permanente Medical Center - Santa Clara
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Santa Cruz, California, Förenta staterna, 95065
- Palo Alto Medical Foundation-Santa Cruz
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Santa Rosa, California, Förenta staterna, 95403
- Kaiser Permanente-Santa Rosa
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Santa Rosa, California, Förenta staterna, 95403
- Sutter Pacific Medical Foundation
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South San Francisco, California, Förenta staterna, 94080
- Kaiser Permanente-South San Francisco
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Sunnyvale, California, Förenta staterna, 94086
- Palo Alto Medical Foundation-Sunnyvale
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Walnut Creek, California, Förenta staterna, 94596
- Kaiser Permanente-Walnut Creek
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Woodland Hills, California, Förenta staterna, 91367
- Kaiser Permanente-Woodland Hills
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Colorado
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Aurora, Colorado, Förenta staterna, 80012
- Rocky Mountain Cancer Centers-Aurora
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Aurora, Colorado, Förenta staterna, 80012
- The Medical Center of Aurora
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Boulder, Colorado, Förenta staterna, 80303
- Boulder Community Foothills Hospital
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Colorado Springs, Colorado, Förenta staterna, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, Förenta staterna, 80907
- Rocky Mountain Cancer Centers-Penrose
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Denver, Colorado, Förenta staterna, 80205
- Kaiser Permanente-Franklin
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Denver, Colorado, Förenta staterna, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, Förenta staterna, 80220
- Rose Medical Center
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Denver, Colorado, Förenta staterna, 80218
- Rocky Mountain Cancer Centers-Midtown
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Denver, Colorado, Förenta staterna, 80220
- Rocky Mountain Cancer Centers-Rose
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Denver, Colorado, Förenta staterna, 80218
- Colorado Blood Cancer Institute
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Denver, Colorado, Förenta staterna, 80222
- Western States Cancer Research NCORP
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Denver, Colorado, Förenta staterna, 80218
- Saint Joseph Hospital - Cancer Centers of Colorado
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Denver, Colorado, Förenta staterna, 80210
- AdventHealth Porter
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Durango, Colorado, Förenta staterna, 81301
- Mercy Medical Center
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Englewood, Colorado, Förenta staterna, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, Förenta staterna, 80113
- Swedish Medical Center
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Golden, Colorado, Förenta staterna, 80401
- Mountain Blue Cancer Care Center
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Greeley, Colorado, Förenta staterna, 80631
- Banner North Colorado Medical Center
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Greenwood Village, Colorado, Förenta staterna, 80111
- Rocky Mountain Cancer Centers-Greenwood Village
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Lafayette, Colorado, Förenta staterna, 80026
- Kaiser Permanente-Rock Creek
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Lakewood, Colorado, Förenta staterna, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Lakewood, Colorado, Förenta staterna, 80228
- CommonSpirit Saint Anthony Hospital Cancer Center
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Littleton, Colorado, Förenta staterna, 80120
- Rocky Mountain Cancer Centers-Littleton
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Littleton, Colorado, Förenta staterna, 80122
- AdventHealth Littleton
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Lone Tree, Colorado, Förenta staterna, 80124
- Sky Ridge Medical Center
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Lone Tree, Colorado, Förenta staterna, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
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Longmont, Colorado, Förenta staterna, 80501
- Longmont United Hospital
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Longmont, Colorado, Förenta staterna, 80501
- Rocky Mountain Cancer Centers-Longmont
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Loveland, Colorado, Förenta staterna, 80539
- Banner North Colorado Medical Center - Loveland Campus
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Parker, Colorado, Förenta staterna, 80138
- Rocky Mountain Cancer Centers-Parker
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Parker, Colorado, Förenta staterna, 80138
- AdventHealth Parker
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Pueblo, Colorado, Förenta staterna, 81004
- Saint Mary Corwin Medical Center
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Thornton, Colorado, Förenta staterna, 80260
- Rocky Mountain Cancer Centers-Thornton
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Wheat Ridge, Colorado, Förenta staterna, 80401
- Intermountain Health Lutheran Hospital
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Connecticut
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Hartford, Connecticut, Förenta staterna, 06105
- Smilow Cancer Hospital Care Center at Saint Francis
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New Britain, Connecticut, Förenta staterna, 06050
- The Hospital of Central Connecticut
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New Haven, Connecticut, Förenta staterna, 06520
- Yale University
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Delaware
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Dover, Delaware, Förenta staterna, 19901
- Bayhealth Hospital Kent Campus
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Lewes, Delaware, Förenta staterna, 19958
- Beebe Medical Center
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Newark, Delaware, Förenta staterna, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, Förenta staterna, 19713
- Delaware Clinical and Laboratory Physicians PA
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Newark, Delaware, Förenta staterna, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, Förenta staterna, 19718
- Christiana Care Health System-Christiana Hospital
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Rehoboth Beach, Delaware, Förenta staterna, 19971
- Beebe Health Campus
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Seaford, Delaware, Förenta staterna, 19973
- TidalHealth Nanticoke / Allen Cancer Center
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District of Columbia
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Washington D.C., District of Columbia, Förenta staterna, 20016
- Sibley Memorial Hospital
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Florida
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Lakeland, Florida, Förenta staterna, 33805
- The Watson Clinic
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Orlando, Florida, Förenta staterna, 32806
- Orlando Health Cancer Institute
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Georgia
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Atlanta, Georgia, Förenta staterna, 30322
- Emory University Hospital/Winship Cancer Institute
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Atlanta, Georgia, Förenta staterna, 30342
- Northside Hospital
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Decatur, Georgia, Förenta staterna, 30033
- Atlanta VA Medical Center
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Lawrenceville, Georgia, Förenta staterna, 30046
- Northside Hospital - Gwinnett
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Macon, Georgia, Förenta staterna, 31201
- Atrium Health Navicent
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Savannah, Georgia, Förenta staterna, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Hawaii
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Honolulu, Hawaii, Förenta staterna, 96817
- The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, Förenta staterna, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, Förenta staterna, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, Förenta staterna, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, Förenta staterna, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, Förenta staterna, 96819
- Kaiser Permanente Moanalua Medical Center
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Idaho
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Boise, Idaho, Förenta staterna, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Boise, Idaho, Förenta staterna, 83712
- Saint Luke's Cancer Institute - Boise
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Fruitland, Idaho, Förenta staterna, 83619
- Saint Luke's Cancer Institute - Fruitland
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Meridian, Idaho, Förenta staterna, 83642
- Saint Luke's Cancer Institute - Meridian
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Nampa, Idaho, Förenta staterna, 83687
- Saint Luke's Cancer Institute - Nampa
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Post Falls, Idaho, Förenta staterna, 83854
- Kootenai Clinic Cancer Services - Post Falls
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Twin Falls, Idaho, Förenta staterna, 83301
- Saint Luke's Cancer Institute - Twin Falls
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Illinois
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Bloomington, Illinois, Förenta staterna, 61704
- Illinois CancerCare-Bloomington
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Canton, Illinois, Förenta staterna, 61520
- Illinois CancerCare-Canton
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Carthage, Illinois, Förenta staterna, 62321
- Illinois CancerCare-Carthage
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Chicago, Illinois, Förenta staterna, 60611
- Northwestern University
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Chicago, Illinois, Förenta staterna, 60657
- UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital
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Chicago, Illinois, Förenta staterna, 60640
- Weiss Memorial Hospital
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Danville, Illinois, Förenta staterna, 61832
- Carle at The Riverfront
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Decatur, Illinois, Förenta staterna, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, Förenta staterna, 62526
- Cancer Care Specialists of Illinois - Decatur
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Decatur, Illinois, Förenta staterna, 62526
- Heartland Cancer Research NCORP
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Effingham, Illinois, Förenta staterna, 62401
- Crossroads Cancer Center
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Effingham, Illinois, Förenta staterna, 62401
- Carle Physician Group-Effingham
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Elk Grove Village, Illinois, Förenta staterna, 60007
- Ascension Alexian Brothers - Elk Grove Village
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Eureka, Illinois, Förenta staterna, 61530
- Illinois CancerCare-Eureka
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Galesburg, Illinois, Förenta staterna, 61401
- Illinois CancerCare-Galesburg
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Geneva, Illinois, Förenta staterna, 60134
- Northwestern Medicine Cancer Center Delnor
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Harvey, Illinois, Förenta staterna, 60426
- Ingalls Memorial Hospital
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Hinsdale, Illinois, Förenta staterna, 60521
- Hinsdale Hematology Oncology Associates Incorporated
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Joliet, Illinois, Förenta staterna, 60435
- Duly Health and Care Joliet
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Kewanee, Illinois, Förenta staterna, 61443
- Illinois CancerCare-Kewanee Clinic
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Macomb, Illinois, Förenta staterna, 61455
- Illinois CancerCare-Macomb
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Mattoon, Illinois, Förenta staterna, 61938
- Carle Physician Group-Mattoon/Charleston
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Moline, Illinois, Förenta staterna, 61265
- Trinity Medical Center
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Monmouth, Illinois, Förenta staterna, 61462
- Illinois CancerCare-Monmouth
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Niles, Illinois, Förenta staterna, 60714
- Illinois Cancer Specialists-Niles
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O'Fallon, Illinois, Förenta staterna, 62269
- Cancer Care Center of O'Fallon
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Ottawa, Illinois, Förenta staterna, 61350
- Illinois CancerCare-Ottawa Clinic
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Pekin, Illinois, Förenta staterna, 61554
- Illinois CancerCare-Pekin
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Peoria, Illinois, Förenta staterna, 61615
- Illinois CancerCare-Peoria
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Peru, Illinois, Förenta staterna, 61354
- Illinois CancerCare-Peru
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Princeton, Illinois, Förenta staterna, 61356
- Illinois CancerCare-Princeton
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River Forest, Illinois, Förenta staterna, 60305
- West Suburban Medical Center
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Rockford, Illinois, Förenta staterna, 61104
- Swedish American Hospital
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Rockford, Illinois, Förenta staterna, 61114
- UW Health Carbone Cancer Center Rockford
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Springfield, Illinois, Förenta staterna, 62702
- Southern Illinois University School of Medicine
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Springfield, Illinois, Förenta staterna, 62702
- Springfield Clinic
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Springfield, Illinois, Förenta staterna, 62702
- Central Illinois Hematology Oncology Center
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Springfield, Illinois, Förenta staterna, 62781
- Springfield Memorial Hospital
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Urbana, Illinois, Förenta staterna, 61801
- Carle Cancer Center
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Urbana, Illinois, Förenta staterna, 61801
- The Carle Foundation Hospital
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Warrenville, Illinois, Förenta staterna, 60555
- Northwestern Medicine Cancer Center Warrenville
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Indiana
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Elkhart, Indiana, Förenta staterna, 46515
- Elkhart General Hospital
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Elkhart, Indiana, Förenta staterna, 46514
- Michiana Hematology Oncology PC-Elkhart
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Elkhart, Indiana, Förenta staterna, 46514-2098
- Elkhart Clinic
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Indianapolis, Indiana, Förenta staterna, 46202
- Indiana University/Melvin and Bren Simon Cancer Center
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Indianapolis, Indiana, Förenta staterna, 46219
- IU Health Central Indiana Cancer Centers-East
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Kokomo, Indiana, Förenta staterna, 46904
- Community Howard Regional Health
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La Porte, Indiana, Förenta staterna, 46350
- IU Health La Porte Hospital
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Lafayette, Indiana, Förenta staterna, 47904
- IU Health Arnett Cancer Care
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Merrillville, Indiana, Förenta staterna, 46410
- Premier Oncology Hematology Associates
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Mishawaka, Indiana, Förenta staterna, 46545
- Michiana Hematology Oncology PC-Mishawaka
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Mishawaka, Indiana, Förenta staterna, 46545
- Saint Joseph Regional Medical Center-Mishawaka
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Muncie, Indiana, Förenta staterna, 47303
- IU Health Ball Memorial Hospital
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Plymouth, Indiana, Förenta staterna, 46563
- Michiana Hematology Oncology PC-Plymouth
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Richmond, Indiana, Förenta staterna, 47374
- Reid Health
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South Bend, Indiana, Förenta staterna, 46628
- Northern Indiana Cancer Research Consortium
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Westville, Indiana, Förenta staterna, 46391
- Michiana Hematology Oncology PC-Westville
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Iowa
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Ames, Iowa, Förenta staterna, 50010
- McFarland Clinic - Ames
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Cedar Rapids, Iowa, Förenta staterna, 52403
- Oncology Associates at Mercy Medical Center
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Clive, Iowa, Förenta staterna, 50325
- Mercy Cancer Center-West Lakes
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Clive, Iowa, Förenta staterna, 50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
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Des Moines, Iowa, Förenta staterna, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Förenta staterna, 50309
- Iowa-Wide Oncology Research Coalition NCORP
-
Des Moines, Iowa, Förenta staterna, 50309
- UI Health Care Mission Cancer and Blood - Des Moines Clinic
-
Des Moines, Iowa, Förenta staterna, 50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
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Mason City, Iowa, Förenta staterna, 50401
- Mercy Medical Center - North Iowa
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Ottumwa, Iowa, Förenta staterna, 52501
- Ottumwa Regional Health Center
-
Sioux City, Iowa, Förenta staterna, 51101
- Siouxland Regional Cancer Center
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Waterloo, Iowa, Förenta staterna, 50702
- MercyOne Waterloo Cancer Center
-
West Des Moines, Iowa, Förenta staterna, 50266
- Mercy Medical Center-West Lakes
-
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Kansas
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Lawrence, Kansas, Förenta staterna, 66044
- Lawrence Memorial Hospital
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Prairie Village, Kansas, Förenta staterna, 66208
- Kansas City NCI Community Oncology Research Program
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Wichita, Kansas, Förenta staterna, 67214
- Wesley Medical Center
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Kentucky
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Bardstown, Kentucky, Förenta staterna, 40004
- CommonSpirit Saint Joseph Hospital - Bardstown
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Louisville, Kentucky, Förenta staterna, 40202
- Jewish Hospital
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Louisville, Kentucky, Förenta staterna, 40245
- UofL Health Medical Center Northeast
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Louisiana
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Baton Rouge, Louisiana, Förenta staterna, 70809
- Ochsner Health Center-Summa
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Kenner, Louisiana, Förenta staterna, 70065
- Ochsner Medical Center Kenner
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Monroe, Louisiana, Förenta staterna, 71202
- Ochsner LSU Health Monroe Medical Center
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New Orleans, Louisiana, Förenta staterna, 70121
- Ochsner Medical Center Jefferson
-
Shreveport, Louisiana, Förenta staterna, 71103
- LSU Health Sciences Center at Shreveport
-
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Maine
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Augusta, Maine, Förenta staterna, 04330
- Harold Alfond Center for Cancer Care
-
Bangor, Maine, Förenta staterna, 04401
- Eastern Maine Medical Center
-
Brewer, Maine, Förenta staterna, 04412
- Lafayette Family Cancer Center-EMMC
-
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Maryland
-
Baltimore, Maryland, Förenta staterna, 21287
- Johns Hopkins University/Sidney Kimmel Cancer Center
-
Baltimore, Maryland, Förenta staterna, 21204
- Greater Baltimore Medical Center
-
Elkton, Maryland, Förenta staterna, 21921
- Christiana Care - Union Hospital
-
Salisbury, Maryland, Förenta staterna, 21801
- TidalHealth Peninsula Regional
-
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Massachusetts
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Boston, Massachusetts, Förenta staterna, 02111
- Tufts Medical Center
-
Boston, Massachusetts, Förenta staterna, 02118
- Boston Medical Center
-
Springfield, Massachusetts, Förenta staterna, 01199
- Baystate Medical Center
-
Worcester, Massachusetts, Förenta staterna, 01655
- UMass Memorial Medical Center - University Campus
-
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Michigan
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Ann Arbor, Michigan, Förenta staterna, 48109
- University of Michigan Rogel Cancer Center
-
Ann Arbor, Michigan, Förenta staterna, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Battle Creek, Michigan, Förenta staterna, 49017
- Bronson Battle Creek
-
Dearborn, Michigan, Förenta staterna, 48124
- Corewell Health Dearborn Hospital
-
Detroit, Michigan, Förenta staterna, 48201
- Wayne State University/Karmanos Cancer Institute
-
Detroit, Michigan, Förenta staterna, 48236
- Henry Ford Health Saint John Hospital
-
Escanaba, Michigan, Förenta staterna, 49829
- OSF Saint Francis Hospital and Medical Group
-
Flint, Michigan, Förenta staterna, 48503
- Genesys Hurley Cancer Institute
-
Grand Rapids, Michigan, Förenta staterna, 49503
- Trinity Health Grand Rapids Hospital
-
Grand Rapids, Michigan, Förenta staterna, 49503
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital
-
Jackson, Michigan, Förenta staterna, 49201
- Allegiance Health
-
Kalamazoo, Michigan, Förenta staterna, 49007
- West Michigan Cancer Center
-
Livonia, Michigan, Förenta staterna, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Muskegon, Michigan, Förenta staterna, 49444
- Trinity Health Muskegon Hospital
-
Pontiac, Michigan, Förenta staterna, 48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Port Huron, Michigan, Förenta staterna, 48060
- Lake Huron Medical Center
-
Reed City, Michigan, Förenta staterna, 49677
- Corewell Health Reed City Hospital
-
Saginaw, Michigan, Förenta staterna, 48601
- MyMichigan Medical Center Saginaw
-
Saint Joseph, Michigan, Förenta staterna, 49085
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
-
Saint Joseph, Michigan, Förenta staterna, 49085
- Corewell Health Lakeland Hospitals - Saint Joseph Hospital
-
Traverse City, Michigan, Förenta staterna, 49684
- Munson Medical Center
-
Warren, Michigan, Förenta staterna, 48093
- Henry Ford Health Warren Hospital
-
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Minnesota
-
Bemidji, Minnesota, Förenta staterna, 56601
- Sanford Joe Lueken Cancer Center
-
Burnsville, Minnesota, Förenta staterna, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, Förenta staterna, 55433
- Mercy Hospital
-
Duluth, Minnesota, Förenta staterna, 55805
- Saint Luke's Hospital of Duluth
-
Duluth, Minnesota, Förenta staterna, 55805
- Essentia Health Cancer Center
-
Edina, Minnesota, Förenta staterna, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, Förenta staterna, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fridley, Minnesota, Förenta staterna, 55432
- Unity Hospital
-
Hutchinson, Minnesota, Förenta staterna, 55350
- Hutchinson Area Health Care
-
Maplewood, Minnesota, Förenta staterna, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Förenta staterna, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Förenta staterna, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Förenta staterna, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Förenta staterna, 55454
- Health Partners Inc
-
Robbinsdale, Minnesota, Förenta staterna, 55422
- North Memorial Medical Health Center
-
Rochester, Minnesota, Förenta staterna, 55905
- Mayo Clinic in Rochester
-
Saint Cloud, Minnesota, Förenta staterna, 56303
- Coborn Cancer Center at Saint Cloud Hospital
-
Saint Louis Park, Minnesota, Förenta staterna, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Louis Park, Minnesota, Förenta staterna, 55416
- Metro Minnesota Community Oncology Research Consortium
-
Saint Paul, Minnesota, Förenta staterna, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Förenta staterna, 55102
- United Hospital
-
Shakopee, Minnesota, Förenta staterna, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Förenta staterna, 55082
- Lakeview Hospital
-
Waconia, Minnesota, Förenta staterna, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Förenta staterna, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Förenta staterna, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
-
Mississippi
-
Jackson, Mississippi, Förenta staterna, 39216
- University of Mississippi Medical Center
-
-
Missouri
-
Bolivar, Missouri, Förenta staterna, 65613
- Central Care Cancer Center - Bolivar
-
Cape Girardeau, Missouri, Förenta staterna, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Förenta staterna, 63703
- Mercy Cancer Center - Cape Girardeau
-
Chesterfield, Missouri, Förenta staterna, 63017
- Saint Luke's Hospital
-
Jefferson City, Missouri, Förenta staterna, 65109
- MU Health Care Goldschmidt Cancer Center
-
Kansas City, Missouri, Förenta staterna, 64111
- Saint Luke's Hospital of Kansas City
-
Rolla, Missouri, Förenta staterna, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Rolla, Missouri, Förenta staterna, 65401
- Phelps Health Delbert Day Cancer Institute
-
Springfield, Missouri, Förenta staterna, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Förenta staterna, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, Förenta staterna, 63131
- Missouri Baptist Medical Center
-
St Louis, Missouri, Förenta staterna, 63109
- Mercy Infusion Center - Chippewa
-
St Louis, Missouri, Förenta staterna, 63141
- Mercy Hospital Saint Louis
-
-
Montana
-
Billings, Montana, Förenta staterna, 59101
- Billings Clinic Cancer Center
-
Bozeman, Montana, Förenta staterna, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, Förenta staterna, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Förenta staterna, 59405
- Benefis Sletten Cancer Institute
-
Kalispell, Montana, Förenta staterna, 59901
- Logan Health Medical Center
-
Missoula, Montana, Förenta staterna, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, Förenta staterna, 59804
- Community Medical Center
-
-
Nebraska
-
Grand Island, Nebraska, Förenta staterna, 68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Kearney, Nebraska, Förenta staterna, 68847
- CHI Health Good Samaritan
-
Lincoln, Nebraska, Förenta staterna, 68506
- Nebraska Hematology and Oncology
-
Lincoln, Nebraska, Förenta staterna, 68510
- Nebraska Cancer Research Center
-
Lincoln, Nebraska, Förenta staterna, 68516
- Cancer Partners of Nebraska
-
Omaha, Nebraska, Förenta staterna, 68198
- University of Nebraska Medical Center
-
-
Nevada
-
Henderson, Nevada, Förenta staterna, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Förenta staterna, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, Förenta staterna, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, Förenta staterna, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, Förenta staterna, 89074
- Oncology Las Vegas - Henderson
-
Las Vegas, Nevada, Förenta staterna, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Förenta staterna, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Förenta staterna, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Förenta staterna, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Förenta staterna, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Förenta staterna, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Förenta staterna, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, Förenta staterna, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, Förenta staterna, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, Förenta staterna, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, Förenta staterna, 89121
- Cancer Therapy and Integrative Medicine
-
Las Vegas, Nevada, Förenta staterna, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, Förenta staterna, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, Förenta staterna, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, Förenta staterna, 89120
- Nevada Cancer Research Foundation NCORP
-
Las Vegas, Nevada, Förenta staterna, 89128
- Oncology Las Vegas - Tenaya
-
Las Vegas, Nevada, Förenta staterna, 89183
- OptumCare Cancer Care at Fort Apache
-
-
New Hampshire
-
Concord, New Hampshire, Förenta staterna, 03301
- New Hampshire Oncology Hematology PA-Concord
-
Dover, New Hampshire, Förenta staterna, 03820
- Wentworth-Douglass Hospital
-
Laconia, New Hampshire, Förenta staterna, 03246
- LRGHealthcare-Lakes Region General Hospital
-
Lebanon, New Hampshire, Förenta staterna, 03756
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
Manchester, New Hampshire, Förenta staterna, 03103
- Solinsky Center for Cancer Care
-
-
New Jersey
-
Camden, New Jersey, Förenta staterna, 08103
- Cooper Hospital University Medical Center
-
Englewood, New Jersey, Förenta staterna, 07631
- Englewood Hospital and Medical Center
-
Livingston, New Jersey, Förenta staterna, 07039
- Cooperman Barnabas Medical Center
-
Mount Holly, New Jersey, Förenta staterna, 08060
- Virtua Memorial
-
Mullica Hill, New Jersey, Förenta staterna, 08062
- Inspira Medical Center Mullica Hill
-
Paramus, New Jersey, Förenta staterna, 07652
- The Valley Hospital - Luckow Pavilion
-
Ridgewood, New Jersey, Förenta staterna, 07450
- Valley Health System Ridgewood Campus
-
Vineland, New Jersey, Förenta staterna, 08360
- Inspira Medical Center Vineland
-
Westwood, New Jersey, Förenta staterna, 07675
- Valley Health System-Hematology/Oncology
-
-
New Mexico
-
Albuquerque, New Mexico, Förenta staterna, 87106
- University of New Mexico Cancer Center
-
Albuquerque, New Mexico, Förenta staterna, 87110
- Presbyterian Kaseman Hospital
-
Las Cruces, New Mexico, Förenta staterna, 88011
- Memorial Medical Center-Las Cruces
-
Santa Fe, New Mexico, Förenta staterna, 87505
- Christus Saint Vincent Regional Cancer Center
-
-
New York
-
Brooklyn, New York, Förenta staterna, 11203
- Kings County Hospital
-
Brooklyn, New York, Förenta staterna, 11203
- State University of New York Downstate Medical Center
-
Buffalo, New York, Förenta staterna, 14263
- Roswell Park Cancer Institute
-
East Syracuse, New York, Förenta staterna, 13057
- Hematology Oncology Associates of Central New York-East Syracuse
-
New York, New York, Förenta staterna, 10032
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
-
New York, New York, Förenta staterna, 10016
- Laura and Isaac Perlmutter Cancer Center at NYU Langone
-
Plattsburgh, New York, Förenta staterna, 12901
- Champlain Valley Physicians Hospital Medical Center
-
Rochester, New York, Förenta staterna, 14642
- University of Rochester
-
Syracuse, New York, Förenta staterna, 13210
- State University of New York Upstate Medical University
-
The Bronx, New York, Förenta staterna, 10461
- Montefiore Medical Center-Einstein Campus
-
The Bronx, New York, Förenta staterna, 10467
- Montefiore Medical Center - Moses Campus
-
The Bronx, New York, Förenta staterna, 10461
- Montefiore Medical Center-Weiler Hospital
-
-
North Carolina
-
Asheboro, North Carolina, Förenta staterna, 27203
- Randolph Hospital
-
Chapel Hill, North Carolina, Förenta staterna, 27599
- UNC Lineberger Comprehensive Cancer Center
-
Clinton, North Carolina, Förenta staterna, 28328
- Southeastern Medical Oncology Center-Clinton
-
Goldsboro, North Carolina, Förenta staterna, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, Förenta staterna, 27534
- Wayne Memorial Hospital
-
Greensboro, North Carolina, Förenta staterna, 27403
- Cone Health Cancer Center
-
Hendersonville, North Carolina, Förenta staterna, 28791
- Margaret R Pardee Memorial Hospital
-
Jacksonville, North Carolina, Förenta staterna, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Kinston, North Carolina, Förenta staterna, 28501
- ECU Health Oncology Kinston
-
Reidsville, North Carolina, Förenta staterna, 27320
- Annie Penn Memorial Hospital
-
Statesville, North Carolina, Förenta staterna, 28677
- Iredell Memorial Hospital
-
Washington, North Carolina, Förenta staterna, 27889
- Marion L Shepard Cancer Center - ECU Health Beaufort Hospital
-
Winston-Salem, North Carolina, Förenta staterna, 27157
- Wake Forest University Health Sciences
-
-
North Dakota
-
Bismarck, North Dakota, Förenta staterna, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, Förenta staterna, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, Förenta staterna, 58122
- Sanford Broadway Medical Center
-
-
Ohio
-
Akron, Ohio, Förenta staterna, 44307
- Cleveland Clinic Akron General
-
Akron, Ohio, Förenta staterna, 44304
- Summa Health System - Akron Campus
-
Barberton, Ohio, Förenta staterna, 44203
- Summa Health System - Barberton Campus
-
Canton, Ohio, Förenta staterna, 44708
- Cleveland Clinic Mercy Hospital
-
Chardon, Ohio, Förenta staterna, 44024
- Geauga Hospital
-
Cincinnati, Ohio, Förenta staterna, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati, Ohio, Förenta staterna, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, Förenta staterna, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, Förenta staterna, 45255
- TriHealth Cancer Institute-Anderson
-
Cleveland, Ohio, Förenta staterna, 44106
- Case Western Reserve University
-
Cleveland, Ohio, Förenta staterna, 44109
- MetroHealth Medical Center
-
Columbus, Ohio, Förenta staterna, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, Förenta staterna, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, Förenta staterna, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Förenta staterna, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, Förenta staterna, 43222
- Mount Carmel Health Center West
-
Columbus, Ohio, Förenta staterna, 43215
- Columbus NCI Community Oncology Research Program
-
Dayton, Ohio, Förenta staterna, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, Förenta staterna, 45409
- Miami Valley Hospital
-
Dayton, Ohio, Förenta staterna, 45415
- Miami Valley Hospital North
-
Elyria, Ohio, Förenta staterna, 44035
- Mercy Cancer Center-Elyria
-
Findlay, Ohio, Förenta staterna, 45840
- Blanchard Valley Hospital
-
Lima, Ohio, Förenta staterna, 45801
- Saint Rita's Medical Center
-
Marietta, Ohio, Förenta staterna, 45750
- Marietta Memorial Hospital
-
Maumee, Ohio, Förenta staterna, 43537
- Toledo Clinic Cancer Centers-Maumee
-
Mayfield Heights, Ohio, Förenta staterna, 44124
- UH Seidman Cancer Center at Landerbrook Health Center
-
Mentor, Ohio, Förenta staterna, 44060
- UH Seidman Cancer Center at Lake Health Mentor Campus
-
Newark, Ohio, Förenta staterna, 43055
- Licking Memorial Hospital
-
Sandusky, Ohio, Förenta staterna, 44870
- UH Seidman Cancer Center at Firelands Regional Medical Center
-
Springfield, Ohio, Förenta staterna, 45504
- Springfield Regional Cancer Center
-
Springfield, Ohio, Förenta staterna, 45504
- Springfield Regional Medical Center
-
Sylvania, Ohio, Förenta staterna, 43560
- ProMedica Flower Hospital
-
Toledo, Ohio, Förenta staterna, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Toledo, Ohio, Förenta staterna, 43614
- University of Toledo
-
Westerville, Ohio, Förenta staterna, 43081
- Saint Ann's Hospital
-
Westlake, Ohio, Förenta staterna, 44145
- UH Seidman Cancer Center at Saint John Medical Center
-
-
Oklahoma
-
Oklahoma City, Oklahoma, Förenta staterna, 73104
- University of Oklahoma Health Sciences Center
-
Tulsa, Oklahoma, Förenta staterna, 74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
-
Oregon
-
Clackamas, Oregon, Förenta staterna, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, Förenta staterna, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, Förenta staterna, 97420
- Bay Area Hospital
-
Newberg, Oregon, Förenta staterna, 97132
- Providence Newberg Medical Center
-
Oregon City, Oregon, Förenta staterna, 97045
- Providence Willamette Falls Medical Center
-
Portland, Oregon, Förenta staterna, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Förenta staterna, 97225
- Providence Saint Vincent Medical Center
-
-
Pennsylvania
-
Allentown, Pennsylvania, Förenta staterna, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, Förenta staterna, 18015
- Saint Luke's University Hospital-Bethlehem Campus
-
Bryn Mawr, Pennsylvania, Förenta staterna, 19010
- Bryn Mawr Hospital
-
Danville, Pennsylvania, Förenta staterna, 17822
- Geisinger Medical Center
-
Doylestown, Pennsylvania, Förenta staterna, 18901
- Doylestown Hospital
-
Drexel Hill, Pennsylvania, Förenta staterna, 19026
- Delaware County Memorial Hospital
-
Ephrata, Pennsylvania, Förenta staterna, 17522
- Ephrata Cancer Center
-
Ephrata, Pennsylvania, Förenta staterna, 17522
- Ephrata Community Hospital
-
Gettysburg, Pennsylvania, Förenta staterna, 17325
- Adams Cancer Center
-
Hanover, Pennsylvania, Förenta staterna, 17331
- WellSpan Medical Oncology and Hematology
-
Hazleton, Pennsylvania, Förenta staterna, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hershey, Pennsylvania, Förenta staterna, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Lewisburg, Pennsylvania, Förenta staterna, 17837
- Geisinger Medical Oncology-Lewisburg
-
Paoli, Pennsylvania, Förenta staterna, 19301
- Paoli Memorial Hospital
-
Philadelphia, Pennsylvania, Förenta staterna, 19111
- Fox Chase Cancer Center
-
Philadelphia, Pennsylvania, Förenta staterna, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, Förenta staterna, 19140
- Temple University Hospital
-
Pottstown, Pennsylvania, Förenta staterna, 19464
- Pottstown Hospital
-
Pottsville, Pennsylvania, Förenta staterna, 17901
- Geisinger Cancer Services-Pottsville
-
Scranton, Pennsylvania, Förenta staterna, 18508
- Hematology and Oncology Associates of North East Pennsylvania
-
Selinsgrove, Pennsylvania, Förenta staterna, 17870
- Geisinger Medical Oncology-Selinsgrove
-
Sellersville, Pennsylvania, Förenta staterna, 18960
- Grand View Hospital
-
State College, Pennsylvania, Förenta staterna, 16803
- Mount Nittany Medical Center
-
West Chester, Pennsylvania, Förenta staterna, 19380
- Chester County Hospital
-
West Reading, Pennsylvania, Förenta staterna, 19611
- Reading Hospital
-
Wilkes-Barre, Pennsylvania, Förenta staterna, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Wynnewood, Pennsylvania, Förenta staterna, 19096
- Lankenau Medical Center
-
York, Pennsylvania, Förenta staterna, 17403
- WellSpan Health-York Hospital
-
-
South Carolina
-
Boiling Springs, South Carolina, Förenta staterna, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Easley, South Carolina, Förenta staterna, 29640
- Prisma Health Cancer Institute - Easley
-
Greenville, South Carolina, Förenta staterna, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, Förenta staterna, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, Förenta staterna, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, Förenta staterna, 29605
- Prisma Health Greenville Memorial Hospital
-
Greenville, South Carolina, Förenta staterna, 29601
- Greenville Health System Cancer Institute-Andrews
-
Greer, South Carolina, Förenta staterna, 29650
- Prisma Health Cancer Institute - Greer
-
Seneca, South Carolina, Förenta staterna, 29672
- Prisma Health Cancer Institute - Seneca
-
-
South Dakota
-
Rapid City, South Dakota, Förenta staterna, 57701
- Rapid City Regional Hospital
-
Sioux Falls, South Dakota, Förenta staterna, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, Förenta staterna, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Förenta staterna, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Nashville, Tennessee, Förenta staterna, 37232
- Vanderbilt University/Ingram Cancer Center
-
-
Texas
-
Austin, Texas, Förenta staterna, 78701
- Dell Seton Medical Center at The University of Texas
-
Dallas, Texas, Förenta staterna, 75235
- Parkland Memorial Hospital
-
Dallas, Texas, Förenta staterna, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
Fort Sam Houston, Texas, Förenta staterna, 78234
- Brooke Army Medical Center
-
Lubbock, Texas, Förenta staterna, 79410
- Covenant Medical Center-Lakeside
-
Lubbock, Texas, Förenta staterna, 79430
- Texas Tech University Health Sciences Center-Lubbock
-
San Antonio, Texas, Förenta staterna, 78229
- University of Texas Health Science Center at San Antonio
-
-
Utah
-
Salt Lake City, Utah, Förenta staterna, 84112
- Huntsman Cancer Institute/University of Utah
-
-
Virginia
-
Charlottesville, Virginia, Förenta staterna, 22908
- University of Virginia Cancer Center
-
Fishersville, Virginia, Förenta staterna, 22939
- Augusta Health Center for Cancer and Blood Disorders
-
Martinsville, Virginia, Förenta staterna, 24112
- Sovah Health Martinsville
-
-
Washington
-
Edmonds, Washington, Förenta staterna, 98026
- Swedish Cancer Institute-Edmonds
-
Longview, Washington, Förenta staterna, 98632
- PeaceHealth Saint John Medical Center
-
Seattle, Washington, Förenta staterna, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, Förenta staterna, 98122
- Swedish Medical Center-First Hill
-
Vancouver, Washington, Förenta staterna, 98664
- PeaceHealth Southwest Medical Center
-
-
West Virginia
-
Charleston, West Virginia, Förenta staterna, 25304
- Vandalia Health/CAMC Institute for Academic Medicine
-
-
Wisconsin
-
Antigo, Wisconsin, Förenta staterna, 54409
- Aspirus Cancer Care-Antigo-Volm Cancer Center
-
Appleton, Wisconsin, Förenta staterna, 54911
- ThedaCare Regional Cancer Center
-
Burlington, Wisconsin, Förenta staterna, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Eau Claire, Wisconsin, Förenta staterna, 54701
- HSHS Sacred Heart Hospital
-
Eau Claire, Wisconsin, Förenta staterna, 54701
- Marshfield Clinic Cancer Center at Sacred Heart
-
Germantown, Wisconsin, Förenta staterna, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, Förenta staterna, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, Förenta staterna, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, Förenta staterna, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, Förenta staterna, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Green Bay, Wisconsin, Förenta staterna, 54301
- Bellin Memorial Hospital
-
Green Bay, Wisconsin, Förenta staterna, 54301-3526
- Green Bay Oncology at Saint Vincent Hospital
-
Johnson Creek, Wisconsin, Förenta staterna, 53038
- University of Wisconsin Carbone Cancer Center - Johnson Creek
-
Kenosha, Wisconsin, Förenta staterna, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, Förenta staterna, 54601
- Gundersen Lutheran Medical Center
-
Madison, Wisconsin, Förenta staterna, 53792
- University of Wisconsin Carbone Cancer Center - University Hospital
-
Madison, Wisconsin, Förenta staterna, 53715
- SSM Health Dean Medical Group - South Madison Campus
-
Manitowoc, Wisconsin, Förenta staterna, 54221
- Holy Family Memorial Hospital
-
Marinette, Wisconsin, Förenta staterna, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marinette, Wisconsin, Förenta staterna, 54143
- Bay Area Medical Center
-
Marshfield, Wisconsin, Förenta staterna, 54449
- Marshfield Medical Center-Marshfield
-
Marshfield, Wisconsin, Förenta staterna, 54449
- Marshfield Medical Center
-
Milwaukee, Wisconsin, Förenta staterna, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, Förenta staterna, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, Förenta staterna, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, Förenta staterna, 53233
- Aurora Sinai Medical Center
-
Minocqua, Wisconsin, Förenta staterna, 54548
- Marshfield Medical Center - Minocqua
-
New Richmond, Wisconsin, Förenta staterna, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, Förenta staterna, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oconto Falls, Wisconsin, Förenta staterna, 54154
- Saint Vincent Hospital Cancer Center at Oconto Falls
-
Oshkosh, Wisconsin, Förenta staterna, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, Förenta staterna, 53406
- Aurora Cancer Care-Racine
-
Rhinelander, Wisconsin, Förenta staterna, 54501
- Saint Mary's Hospital
-
Rhinelander, Wisconsin, Förenta staterna, 54501
- Aspirus Cancer Care-Rhinelander-James Beck Cancer Center
-
Rice Lake, Wisconsin, Förenta staterna, 54868
- Marshfield Medical Center-Rice Lake
-
Rice Lake, Wisconsin, Förenta staterna, 54868
- Lakeview Medical Center-Marshfield Clinic
-
Sheboygan, Wisconsin, Förenta staterna, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Stevens Point, Wisconsin, Förenta staterna, 54481
- Aspirus Cancer Care - Stevens Point
-
Summit, Wisconsin, Förenta staterna, 53066
- Aurora Medical Center in Summit
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Two Rivers, Wisconsin, Förenta staterna, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
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Waukesha, Wisconsin, Förenta staterna, 53188
- UW Cancer Center at ProHealth Care
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Waukesha, Wisconsin, Förenta staterna, 53188
- ProHealth Waukesha Memorial Hospital
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Waukesha, Wisconsin, Förenta staterna, 53188
- Aurora Cancer Care-Waukesha
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Wausau, Wisconsin, Förenta staterna, 54401
- Marshfield Clinic-Wausau Center
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Wausau, Wisconsin, Förenta staterna, 54401
- Aspirus Cancer Care-Wausau
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Wauwatosa, Wisconsin, Förenta staterna, 53226
- Aurora Cancer Care-Milwaukee West
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West Allis, Wisconsin, Förenta staterna, 53227
- Aurora West Allis Medical Center
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Weston, Wisconsin, Förenta staterna, 54476
- Marshfield Medical Center - Weston
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Wisconsin Rapids, Wisconsin, Förenta staterna, 54494
- Aspirus Cancer Care - Wisconsin Rapids
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Wisconsin Rapids, Wisconsin, Förenta staterna, 54494
- Marshfield Clinic - Wisconsin Rapids Center
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Deltagandekriterier
Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.
Urvalskriterier
Åldrar som är berättigade till studier
18 år och äldre (Vuxen, Äldre vuxen)
Tar emot friska volontärer
Nej
Kön som är behöriga för studier
Allt
Beskrivning
Inclusion Criteria:
- PRE-REGISTRATION (STEP 0)
- Histologically confirmed DLBCL expressing CD20 antigen; patients with transformed lymphoma are excluded; in this regard, patients with composite lymphoma in the diagnostic tissue (concomitant DLBCL and follicular or other low-grade lymphoma component) are excluded; however, patients with DLBCL in primary diagnostic tissue but a bone marrow that shows low grade or indeterminate lymphoma are eligible; patients with known primary mediastinal large B-cell lymphoma (PMLBCL) are excluded; similarly, patients with known c-myc translocation (by fluorescence in situ hybridization) positive DLBCL are encouraged to participate in trials specifically designed for these patients; however patients with known c-myc DLBC positive are NOT excluded from this study; c-myc testing prior to study enrollment is NOT required
- Stages II bulky disease (defined as mass size of more than 10 cm), stage III, or IV (Ann Arbor staging); patients with stage I and stage II non-bulky disease are excluded from this study
- A paraffin-embedded tumor tissue specimen from the initial diagnostic biopsy has been located and ready to ship to the Mayo Clinic Lymphoma Laboratory following pre-registration; Note: excisional tumor biopsy is preferred; core needle biopsies will be considered adequate if there is enough tissue for the mandatory central pathology review immunohistochemistry and Genomics Education Partnership (GEP); submission of a tumor block is preferred, but if unavailable submit alternative materials
- Eastern Cooperative Oncology Group (ECOG) performance status 0-2
- Previously untreated and not receiving any other agent that would be considered as a treatment for the lymphoma; for subjects with severe systemic symptoms, compressive disease, or rapidly progressing symptomatic adenopathy, are allowed for lymphoma associated symptom treatment with up to 1 mg/kg/day prednisone, or equivalent, for a maximum of 7 days is permitted prior to beginning the treatment, at the discretion of the investigator; a washout period does not apply
- No known central nervous system (CNS) lymphoma or cerebrospinal fluid involvement with malignant lymphoma cells; these patients are usually treated with CNS directed therapy; screening for cerebrospinal fluid (CSF)/CNS involvement is NOT required but can be performed per treating medical doctor (MD) discretion; intrathecal (IT) methotrexate or IT cytarabine prophylaxis in patients with negative CSF who are felt to be at high risk of CNS relapse is allowed per local MD discretion; this should be noted on the treatment form
- Absence of history of myocardial infarction =< 6 months, or congestive heart failure requiring use of ongoing maintenance therapy for life-threatening ventricular arrhythmias
- Absence of history of deep venous thrombosis/embolism, threatening thromboembolism or known thrombophilia; patients with a history of deep vein thrombosis(DVT)/pulmonary embolism (PE) or thrombophilia may participate if they are willing to be on full anticoagulation during the treatment if randomized to rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone (R2CHOP) arm A; full anticoagulation is defined as warfarin, factor X inhibitors, or low molecular weight heparin at therapeutic doses
- Patient must be able and willing to receive anticoagulation therapy with aspirin 70-325 mg daily prophylaxis, low molecular weight heparin, factor X inhibitors or warfarin; patients unable or unwilling to take any prophylaxis are NOT eligible
- Absence of history of acquired immune deficiency syndrome (AIDS)-related conditions (other than the presenting DLBCL) or post-transplant lymphoproliferative disorder (PTLD) in immunocompromised patients; patients with human immunodeficiency virus (HIV) on antiretroviral therapy other than zidovudine (AZT) and/or stavudine and without prior AIDS defining conditions and adequate CD4 count (> 400) are eligible
- No other active malignancy requiring therapy such as radiation, chemotherapy, or immunotherapy; exceptions to this are as follows: localized non-melanotic skin cancer and any cancer that in the judgment of the investigator has been treated with curative intent and will not interfere with the study treatment plan and response assessment
- No history of radiation therapy to >= 25% of the bone marrow for other diseases or history of anthracycline therapy
- Patients must not be receiving erythroid stimulating agents (EPO: Procrit, Aranesp)
- RANDOMIZATION (STEP 1)
- Patient meets the eligibility criteria outlined above
- Site has received notification from Mayo Clinic - Rochester Division of Hematopathology of the central confirmation of diagnosis and tissue adequacy for mandatory research studies
- Patients must have measurable disease (at least 1 lesion of >= 1.5 cm in one diameter) as detected by computed tomography (CT) or the CT images of the positron emission tomography (PET)/CT
- International Prognostic Index (IPI) of 2 or greater
- Ejection fraction of >= 45% by either multi-gated acquisition (MUGA) scan or echocardiogram (ECHO)
- Absence of co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens, including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
- Absolute neutrophil count (ANC) >= 1500
- Platelets (PLT) >= 100,000
- Total bilirubin =< 1.5 x upper limit of normal (ULN) or if total bilirubin is > 1.5 x ULN, the direct bilirubin must be normal
- Alkaline (Alk.) phosphatase =< 3 x ULN unless evidence of the direct liver involvement by lymphoma - then =< 5 x ULN
- Aspartate aminotransferase (AST) =< 3 x ULN unless evidence of the direct liver involvement by lymphoma - then =< 5 x ULN
- Creatinine =< 2 x ULN or creatinine clearance (CrCl) > 30 ml/min
- Women must not be pregnant or breast-feeding
- Females of childbearing potential (FCBP) must have a negative serum or urine pregnancy test with a sensitivity of at least 25 mIU/mL within 10-14 days prior to and again within 24 hours of starting lenalidomide and must either commit to continued abstinence from heterosexual intercourse or begin TWO acceptable methods of birth control, one highly effective method and one additional effective method AT THE SAME TIME, at least 28 days before she starts taking lenalidomide; FCBP must also agree to ongoing pregnancy testing; a female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
- Men must agree to use a latex condom during sexual contact with a FCBP even if they have had a successful vasectomy; all patients must be counseled at a minimum of every 28 days about pregnancy precautions and risks of fetal exposure
Studieplan
Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.
Hur är studien utformad?
Designdetaljer
- Primärt syfte: Behandling
- Tilldelning: Randomiserad
- Interventionsmodell: Parallellt uppdrag
- Maskning: Ingen (Open Label)
Vapen och interventioner
Deltagargrupp / Arm |
Intervention / Behandling |
|---|---|
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Experimentell: Arm A (rituximab, combination chemotherapy, lenalidomide)
Patients receive rituximab IV, cyclophosphamide IV, doxorubicin hydrochloride IV, and vincristine sulfate IV on day 1; prednisone PO on days 1-5; and lenalidomide PO on days 1-10. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity. |
Correlative studies Given IV
Andra namn:
Given IV
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Given PO
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Given PO
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Given IV
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Given IV
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Aktiv komparator: Arm B (rituximab, combination chemotherapy)
Patients receive rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone as in Arm A. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity. |
Correlative studies Given IV
Andra namn:
Given IV
Andra namn:
Given PO
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Given IV
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Given IV
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Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
3-year Progression-free Survival Rate
Tidsram: Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10, 3-year PFS rate reported
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Progression-free survival is defined as the time from randomization to disease progression, new primary of the same type or death, whichever occurs first. Progressive disease is defined as:
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Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10, 3-year PFS rate reported
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Sekundära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Proportion of Patients With Response
Tidsram: Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10
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Response is defined as complete response (CR) or partial response (PR) CR: Complete disappearance of all detectable clinical evidence of disease and disease-related symptoms PR:
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Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10
|
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Proportion of Patients With Complete Response
Tidsram: Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10
|
Complete response is defined as complete disappearance of all detectable clinical evidence of disease, and disease-related symptoms if present prior to therapy. |
Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10
|
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Overall Survival Rate at 3 Years
Tidsram: Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10
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Overall survival is defined as time from randomization to death or date last known alive. Overall survival rate at 3 years was calculated using the method of Kaplan Meier. |
Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10
|
Andra resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Inverkan av DLBCL Molecular Subtype på resultatet.
Tidsram: Bedöms vid baslinjen, var tredje månad i 2 år, var 6:e månad för år 3 och sedan årligen i år 4-10
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Bedöms vid baslinjen, var tredje månad i 2 år, var 6:e månad för år 3 och sedan årligen i år 4-10
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Interim PET Scan Results in Relation to Treatment Outcome
Tidsram: Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10
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Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10
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Samarbetspartners och utredare
Det är här du hittar personer och organisationer som är involverade i denna studie.
Sponsor
Utredare
- Huvudutredare: Grzegorz S Nowakowski, ECOG-ACRIN Cancer Research Group
Publikationer och användbara länkar
Den som ansvarar för att lägga in information om studien tillhandahåller frivilligt dessa publikationer. Dessa kan handla om allt som har med studien att göra.
Studieavstämningsdatum
Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.
Studera stora datum
Studiestart (Faktisk)
27 augusti 2013
Primärt slutförande (Faktisk)
26 mars 2020
Avslutad studie (Beräknad)
31 december 2026
Studieregistreringsdatum
Först inskickad
14 maj 2013
Först inskickad som uppfyllde QC-kriterierna
14 maj 2013
Första postat (Beräknad)
17 maj 2013
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
27 oktober 2026
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
24 oktober 2026
Senast verifierad
1 oktober 2026
Mer information
Termer relaterade till denna studie
Ytterligare relevanta MeSH-villkor
- Aminosyror, peptider och proteiner
- Proteiner
- Organiska kemikalier
- Heterocykliska föreningar, 1-ring
- Heterocykliska föreningar
- Heterocykliska föreningar, 2-ring
- Heterocykliska föreningar, smältring
- Kolväten
- Kolväten, cykliska
- Kolhydrater
- Karboxylsyror
- Alkaloider
- Polycykliska aromatiska kolväten
- Kolväten, aromatisk
- Polycykliska föreningar
- Glykosider
- Piperidiner
- Förenad
- Antikroppar, monoklonal
- Antikroppar
- Immunglobuliner
- Immunoproteiner
- Blodproteiner
- Serumglobuliner
- Globuliner
- Graviditet
- Graviditet
- Steroider
- Fusion-ringföreningar
- Fosforamidsen
- Kväve senapsföreningar
- Senapsföreningar
- Kolväten, halogenerad
- Fosforamider
- Organofosforföreningar
- Gravidioder
- Vinca alkaloider
- Secologanin tryptaminalkaloider
- Indolalkaloider
- Indolizidiner
- Indoliziner
- Anthracykliner
- Naftakener
- Aminoglykosider
- Antikroppar, monoklonal, murin härledd
- Daunorubicin
- Ftalimider
- Ftalinsyror
- Syror, karbocyklisk
- Piperidoner
- Isoindol
- Lenalidomid
- Rituximab
- Prednison
- Cyklofosfamid
- Doxorubicin
- Vincristine
- Ct-p10
- deltacortene
- prednyliden
Andra studie-ID-nummer
- NCI-2013-00959
- U10CA180820 (U.S.S. NIH-anslag/kontrakt)
- U24CA196172 (U.S.S. NIH-anslag/kontrakt)
- U10CA021115 (U.S.S. NIH-anslag/kontrakt)
- NCI-2013-00959 (Registeridentifierare: CTRP (Clinical Trial Reporting Program))
- ECOG-E1412
- S13-01316
- E1412 (Annan identifierare: CTEP)
- E1412
- E1412 (Annan identifierare: ECOG-ACRIN Cancer Research Group)
Denna information hämtades direkt från webbplatsen clinicaltrials.gov utan några ändringar. Om du har några önskemål om att ändra, ta bort eller uppdatera dina studieuppgifter, vänligen kontakta register@clinicaltrials.gov. Så snart en ändring har implementerats på clinicaltrials.gov, kommer denna att uppdateras automatiskt även på vår webbplats .