Clinical Scores, Biomarkers, and CT Findings in Acute Pulmonary Embolism (PEST)
Comparing Clinical Scores, Biomarkers, and CT Findings in Patients With Acute Pulmonary Embolism Across Different Hospital Departments
This study aims to compare clinical scoring systems, laboratory biomarkers, and computed tomography (CT) findings in patients diagnosed with acute pulmonary embolism in different hospital departments.
The study will include patients diagnosed with acute pulmonary embolism at Sohag University Hospital. Clinical data, laboratory results, and imaging findings will be collected and analyzed to evaluate their diagnostic and prognostic value.
The goal of this research is to identify the most reliable and practical tools for early diagnosis and risk stratification of acute pulmonary embolism, which may help improve patient management and outcomes.
This is an observational study and does not involve any intervention or change in standard patient care.
Aperçu de l'étude
Statut
Les conditions
Intervention / Traitement
Description détaillée
This study is an observational analytical study designed to evaluate and compare clinical scoring systems, laboratory biomarkers, and computed tomography (CT) findings in patients presenting with acute pulmonary embolism (PE) across different hospital departments at Sohag University Hospital.
Acute pulmonary embolism is a potentially life-threatening condition that requires prompt diagnosis and risk stratification. Various clinical scores (such as Wells score and Geneva score), along with laboratory biomarkers (such as D-dimer and others), and imaging modalities (especially CT pulmonary angiography), are commonly used in the diagnostic and assessment process.
The study aims to assess the diagnostic accuracy and clinical usefulness of these parameters, individually and in combination, in patients with confirmed acute pulmonary embolism.
Data will be collected retrospectively and/or prospectively from patient records and clinical assessments. Variables will include demographic data, clinical presentation, risk factors, laboratory investigations, clinical scoring systems, and radiological findings.
The study will compare these parameters across different hospital departments to determine variations in presentation and diagnostic approaches, as well as to evaluate the best predictive indicators for disease severity and outcomes.
The findings of this study may contribute to improving clinical decision-making, optimizing diagnostic strategies, and enhancing early identification of high-risk patients with acute pulmonary embolism.
This is a non-interventional observational study, and no experimental treatment or intervention will be applied. All data will be handled with confidentiality and in accordance with ethical standards and institutional review board (IRB) approval.
Type d'étude
Inscription (Estimé)
Critères de participation
Critère d'éligibilité
Âges éligibles pour étudier
- Adulte
- Adulte plus âgé
Accepte les volontaires sains
Méthode d'échantillonnage
Population étudiée
La description
Inclusion Criteria:
• Adults aged ≥ 18 years
- Confirmed acute pulmonary embolism by CTPA
Exclusion Criteria:
• Chronic pulmonary embolism
- Non-diagnostic CTPA
- Refusal to participate
- Severe renal impairment precluding contrast-enhanced CT
- Known hypersensitivity to contrast media
Plan d'étude
Comment l'étude est-elle conçue ?
Détails de conception
Cohortes et interventions
Groupe / Cohorte |
Intervention / Traitement |
|---|---|
|
Acute Pulmonary Embolism Group
This cohort includes patients diagnosed with acute pulmonary embolism at Sohag University Hospital.
Participants will be evaluated using clinical scoring systems, laboratory biomarkers, and computed tomography pulmonary angiography (CTPA) findings.
No interventions will be applied, and all data will be collected as part of routine clinical care for observational analysis.
|
This is an observational study with no active intervention.
All data are collected from routine clinical care, including clinical scoring systems, laboratory biomarkers, and computed tomography pulmonary angiography (CTPA) findings in patients with acute pulmonary embolism.
|
Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
Number of Participants with In-Hospital All-Cause Mortality
Délai: Up to 30 days
|
All-cause mortality among adult patients with confirmed acute pulmonary embolism, defined as death from any cause occurring during hospitalization.
The outcome will be assessed as the number of participants who die before hospital discharge.
|
Up to 30 days
|
Collaborateurs et enquêteurs
Parrainer
Dates d'enregistrement des études
Dates principales de l'étude
Début de l'étude (Estimé)
Achèvement primaire (Estimé)
Achèvement de l'étude (Estimé)
Dates d'inscription aux études
Première soumission
Première soumission répondant aux critères de contrôle qualité
Première publication (Réel)
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Réel)
Dernière mise à jour soumise répondant aux critères de contrôle qualité
Dernière vérification
Plus d'information
Termes liés à cette étude
Mots clés
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- PE-Score-CT-2025
Informations sur les médicaments et les dispositifs, documents d'étude
Étudie un produit pharmaceutique réglementé par la FDA américaine
Étudie un produit d'appareil réglementé par la FDA américaine
Ces informations ont été extraites directement du site Web clinicaltrials.gov sans aucune modification. Si vous avez des demandes de modification, de suppression ou de mise à jour des détails de votre étude, veuillez contacter register@clinicaltrials.gov. Dès qu'un changement est mis en œuvre sur clinicaltrials.gov, il sera également mis à jour automatiquement sur notre site Web .