Clinical Scores, Biomarkers, and CT Findings in Acute Pulmonary Embolism (PEST)
Comparing Clinical Scores, Biomarkers, and CT Findings in Patients With Acute Pulmonary Embolism Across Different Hospital Departments
This study aims to compare clinical scoring systems, laboratory biomarkers, and computed tomography (CT) findings in patients diagnosed with acute pulmonary embolism in different hospital departments.
The study will include patients diagnosed with acute pulmonary embolism at Sohag University Hospital. Clinical data, laboratory results, and imaging findings will be collected and analyzed to evaluate their diagnostic and prognostic value.
The goal of this research is to identify the most reliable and practical tools for early diagnosis and risk stratification of acute pulmonary embolism, which may help improve patient management and outcomes.
This is an observational study and does not involve any intervention or change in standard patient care.
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Status
Condições
Intervenção / Tratamento
Descrição detalhada
This study is an observational analytical study designed to evaluate and compare clinical scoring systems, laboratory biomarkers, and computed tomography (CT) findings in patients presenting with acute pulmonary embolism (PE) across different hospital departments at Sohag University Hospital.
Acute pulmonary embolism is a potentially life-threatening condition that requires prompt diagnosis and risk stratification. Various clinical scores (such as Wells score and Geneva score), along with laboratory biomarkers (such as D-dimer and others), and imaging modalities (especially CT pulmonary angiography), are commonly used in the diagnostic and assessment process.
The study aims to assess the diagnostic accuracy and clinical usefulness of these parameters, individually and in combination, in patients with confirmed acute pulmonary embolism.
Data will be collected retrospectively and/or prospectively from patient records and clinical assessments. Variables will include demographic data, clinical presentation, risk factors, laboratory investigations, clinical scoring systems, and radiological findings.
The study will compare these parameters across different hospital departments to determine variations in presentation and diagnostic approaches, as well as to evaluate the best predictive indicators for disease severity and outcomes.
The findings of this study may contribute to improving clinical decision-making, optimizing diagnostic strategies, and enhancing early identification of high-risk patients with acute pulmonary embolism.
This is a non-interventional observational study, and no experimental treatment or intervention will be applied. All data will be handled with confidentiality and in accordance with ethical standards and institutional review board (IRB) approval.
Tipo de estudo
Inscrição (Estimado)
Critérios de participação
Critérios de elegibilidade
Idades elegíveis para estudo
- Adulto
- Adulto mais velho
Aceita Voluntários Saudáveis
Método de amostragem
População do estudo
Descrição
Inclusion Criteria:
• Adults aged ≥ 18 years
- Confirmed acute pulmonary embolism by CTPA
Exclusion Criteria:
• Chronic pulmonary embolism
- Non-diagnostic CTPA
- Refusal to participate
- Severe renal impairment precluding contrast-enhanced CT
- Known hypersensitivity to contrast media
Plano de estudo
Como o estudo é projetado?
Detalhes do projeto
Coortes e Intervenções
Grupo / Coorte |
Intervenção / Tratamento |
|---|---|
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Acute Pulmonary Embolism Group
This cohort includes patients diagnosed with acute pulmonary embolism at Sohag University Hospital.
Participants will be evaluated using clinical scoring systems, laboratory biomarkers, and computed tomography pulmonary angiography (CTPA) findings.
No interventions will be applied, and all data will be collected as part of routine clinical care for observational analysis.
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This is an observational study with no active intervention.
All data are collected from routine clinical care, including clinical scoring systems, laboratory biomarkers, and computed tomography pulmonary angiography (CTPA) findings in patients with acute pulmonary embolism.
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O que o estudo está medindo?
Medidas de resultados primários
Medida de resultado |
Descrição da medida |
Prazo |
|---|---|---|
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Number of Participants with In-Hospital All-Cause Mortality
Prazo: Up to 30 days
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All-cause mortality among adult patients with confirmed acute pulmonary embolism, defined as death from any cause occurring during hospitalization.
The outcome will be assessed as the number of participants who die before hospital discharge.
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Up to 30 days
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Colaboradores e Investigadores
Patrocinador
Datas de registro do estudo
Datas Principais do Estudo
Início do estudo (Estimado)
Conclusão Primária (Estimado)
Conclusão do estudo (Estimado)
Datas de inscrição no estudo
Enviado pela primeira vez
Enviado pela primeira vez que atendeu aos critérios de CQ
Primeira postagem (Real)
Atualizações de registro de estudo
Última Atualização Postada (Real)
Última atualização enviada que atendeu aos critérios de controle de qualidade
Última verificação
Mais Informações
Termos relacionados a este estudo
Palavras-chave
Termos MeSH relevantes adicionais
Outros números de identificação do estudo
- PE-Score-CT-2025
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Ensaios clínicos em No Intervention (Observational Study Data Collection)
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Cairo UniversityConcluídoEsclerose Múltipla Remitente-RecorrenteEgito