Vaccine Therapy in Treating Patients With Metastatic Prostate Cancer That Has Not Responded to Hormone Therapy

DISEASE CHARACTERISTICS: Histologically confirmed metastatic hormone-refractory prostate cancer Castrate serum testosterone less than 30 ng/dL after antiandrogen withdrawal Progressing disease 50% increase in PSA level from the nadir PSA level confirmed twice and measured at least 2 weeks apart OR New bone pain or new lesion on bone scan OR Progression of soft tissue disease by CT or MRI Limited bone disease No more than 3 metastatic sites on bone scan and minimal symptoms No brain metastases

PATIENT CHARACTERISTICS: Age: 18 and over Performance status: Zubrod 0-1 Life expectancy: At least 1 year Hematopoietic: Hemoglobin greater than 12.5 g/dL Absolute lymphocyte count greater than 500/mm3 Absolute neutrophil count greater than 1,000/mm3 Platelet count greater than 150,000/mm3 Hepatic: Bilirubin less than 1.5 mg/dL SGOT/SGPT less than 2 times upper limit of normal Hepatitis C negative Hepatitis B surface antigen and hepatitis B core antigen negative No uncontrolled liver disease Renal: Creatinine less than 2.5 mg/dL Creatinine clearance greater than 50 mL/min No uncontrolled renal disease Cardiovascular: No uncontrolled heart disease Immunologic: No history of severe asthma, anaphylaxis, or other serious adverse reaction to vaccines or any of the antigens included in skin test No immunodeficiency or autoimmune disease such as rheumatoid arthritis, systemic lupus erythematosus, scleroderma, polymyositis dermatomyositis, juvenile-onset insulin-dependent diabetes, or vasculitis Negative PPD skin test No prior BCG vaccination or tuberculosis exposure HIV negative Other: No impending untreated spinal cord compression or urinary outlet obstruction No other serious concurrent illness No other prior malignancy in past 2 years except curatively treated basal cell or squamous cell carcinoma of the skin

PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No prior chemotherapy for metastatic disease Endocrine therapy: See Disease Characteristics Hormonal therapy (except antiandrogens like LHRH) must be continued Radiotherapy: No prior radiotherapy for metastatic disease including strontium chloride Sr 89 Surgery: No prior splenectomy Other: No prior ketoconazole At least 4 weeks since prior immunosuppressives (e.g., prednisone or hydrocortisone) No prior investigational agents No concurrent medication that may affect immune function except nonprescription strength doses of nonsteroidal anti-inflammatory drugs, acetaminophen, or aspirin; low doses of antihistamine; normal doses of vitamins; or H2 blockers No more than 2 short courses (no more than 10 days per course) of antibiotics for treatment of minor infection in a 45 day span