A Study to Characterize Event Related Potential Markers of Attentional Bias Towards Words and Images of Food
An Experimental Medicine Study to Characterize Event Related Potential Markers of Attentional Bias Towards Words and Images of Food in Healthy Volunteers
A tanulmány áttekintése
Állapot
Körülmények
Beavatkozás / kezelés
Részletes leírás
GlaxoSmithKline is currently developing a number of drugs for the treatment of overheating including 'binge eating' in obesity. Historically, the behavioural effectiveness of anti-obesity drugs in clinical drug trials have utilised subjective rating scales to assess a person's drive or motivation to eat. Findings from these studies have good construct validity, but suffer from the shortcomings of self-reporting, e.g. the subject bias, dishonesty, misinterpretation. It follows that in addition to self-reporting, it would strengthen the interpretation of any future studies on anti-obesity drugs, if there were to be an objective measure of brain activity in relation to cognitive/motivational processes associated with evaluation and responding to food related cues.
Measuring event related potentials (ERPs) during cognitive processes of food related cues, using the electroencephalography technique (EEG) offers a an alternative objective approach to examining the effectives of anti-obesity drugs.
This protocol proposes to develop and use two cognitive tasks examining response to food related cues (pictorial and words) with concurrent recording of ERPs, in order to characterize neurophysiological events associated with attentional bias towards food related stimuli.
The first task is an image processing task. This task uses food images similar to those in the International Affective Picture System (IAPS) used in ERP studies of perceptual processing of emotional stimuli [Olofsson, 2008; Schupp, 2006]. In this task a subject views different categories of images; palatable high-calorie food images, non-palatable low-calorie food images and non-edible plant images. The latter is the neutral category against which the ERPs of the two food categories will be compared. Affective pictures have been used to assess emotional valence by measuring differences in anterior ERP measurements between images from differing groups.
The protocol also proposes to measure late positive potential in order to assess higher level cognitive processing possibly with early memory formation. Again, the proposal is to assess AUCs, in this case in the 400-600 ms region and then look at difference curves between the late potential potentials to different valency stimuli. For the late positive potentials, anterior laterality will also be assessed. The second task is a cued-target task of visuospatial attention to motivationally salient words. The task is a version of the Posner paradigm. The appearance of a food or nonfood word inside a top or bottom frame (the cue) distracts the attention of the subject towards that spatial location. Following the word either one of the two frames changes appearance (the target).
In addition to these emotion and attention measures, the protocol proposes to assess the more standard N1, P1 and P3 [Luck, 2005]. After completing the ERP recordings the subject will be asked to rate each picture for salience and valence in order to provide a comparison between objective neurophysiological and subjective attention and emotional ratings.
Tanulmány típusa
Beiratkozás (Tényleges)
Fázis
- 1. fázis
Kapcsolatok és helyek
Tanulmányi helyek
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Cambridge, Egyesült Királyság, CB2 2GG
- GSK Investigational Site
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Részvételi kritériumok
Jogosultsági kritériumok
Tanulmányozható életkorok
Egészséges önkénteseket fogad
Tanulmányozható nemek
Leírás
Inclusion Criteria:
Healthy as judged by the responsible physician or designee based on a medical evaluation including medical history.
- Right handed male between 18 and 65 years of age inclusive, at the time of signing the informed consent.
- BMI within the range 27 - 35 kg/m2 (inclusive).
- Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form.
Exclusion Criteria:
A subject will not be eligible for inclusion in this study if any of the following criteria apply:
- The subject has either a previous disease or current medical condition, which as judged by the Investigator, may affect the interpretation of efficacy data. These diseases include, but are not limited to, cardiovascular disease, malignancy, hepatic disease, renal disease, haematological disease, neurological disease, psychiatric diseases or endocrine disease.
- The subject has a positive urine drug screen. A minimum list of drugs that will be screened for include Amphetamines, Barbiturates, Cocaine, Opiates, Cannabinoids, Methadone and Benzodiazepines.
- The subject has a history of alcohol or substance abuse or dependence in the 6 months prior to screening as determined by the investigator. Abuse of alcohol, defined for males, as an average weekly intake of greater than 28 units (or an average daily intake of greater than 4 units). One unit is equivalent to a half-pint (220mL) of beer or 1 (25mL) measure of spirits or 1 glass (125mL) of wine.
- A positive alcohol breath test.
- The subject has a history of stroke, seizures, epilepsy or abnormal EEG.
- The subject is a smoker.
- The subject has participated in a clinical trial and has received an investigational product within the following time period prior to the first dosing day in the current study: 30 days, 5 half-lives or twice the duration of the biological effect of the investigational product (whichever is longer).
- Subjects who are currently taking any regular medication.
- Subject has a history of clinically significant eating disorders.
- Subject is a vegetarian.
- Subject is a member of GlaxoSmithKline Clinical Unit staff.
- Subject is female.
Tanulási terv
Hogyan készül a tanulmány?
Tervezési részletek
- Elsődleges cél: Alapvető tudomány
- Kiosztás: Nem véletlenszerű
- Beavatkozó modell: Egyetlen csoportos hozzárendelés
- Maszkolás: Nincs (Open Label)
Fegyverek és beavatkozások
Résztvevő csoport / kar |
Beavatkozás / kezelés |
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Egyéb: Visit B
At approximately 09:00 the subject will be given breakfast.
After this, no food will be served until study procedures for the day are over.
However, a 330 ml bottle of still water at room temperature will be given at ~11:00 and at ~13:00.
During this period the subject will be required to remain in the unit.
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Subject fed a standard high calorie lunch at 1pm
At approximately 09:00 the subject will be given breakfast.
After this, no food will be served until study procedures for the day are over.
However, a 330 ml bottle of still water at room temperature will be given at ~11:00 and at ~13:00.
During this period the subject will be required to remain in the unit.
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Egyéb: Visit A
At approximately 13:00 the subject will be given a standard high calorie lunch that the subject is required to finish
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Subject fed a standard high calorie lunch at 1pm
At approximately 09:00 the subject will be given breakfast.
After this, no food will be served until study procedures for the day are over.
However, a 330 ml bottle of still water at room temperature will be given at ~11:00 and at ~13:00.
During this period the subject will be required to remain in the unit.
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Mit mér a tanulmány?
Elsődleges eredményintézkedések
Eredménymérő |
Időkeret |
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Event Related Potential Amplitude, Latency and Area Under the Curve, Reaction
Időkeret: 1 hour
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1 hour
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Másodlagos eredményintézkedések
Eredménymérő |
Időkeret |
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Hip-to-waist ratio and BMI
Időkeret: 6 hours
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6 hours
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Együttműködők és nyomozók
Szponzor
Tanulmányi rekorddátumok
Tanulmány főbb dátumok
Tanulmány kezdete
Elsődleges befejezés (Tényleges)
A tanulmány befejezése (Tényleges)
Tanulmányi regisztráció dátumai
Először benyújtva
Először nyújtották be, amely megfelel a minőségbiztosítási kritériumoknak
Első közzététel (Becslés)
Tanulmányi rekordok frissítései
Utolsó frissítés közzétéve (Becslés)
Az utolsó frissítés elküldve, amely megfelel a minőségbiztosítási kritériumoknak
Utolsó ellenőrzés
Több információ
A tanulmányhoz kapcsolódó kifejezések
Egyéb vizsgálati azonosító számok
- 112336
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