A Study Of PF-05280586 (Rituximab-Pfizer) Or MabThera® (Rituximab-EU) For The First-Line Treatment Of Patients With CD20-Positive, Low Tumor Burden, Follicular Lymphoma (REFLECTIONS B328-06)
18 giugno 2019 aggiornato da: Pfizer
A PHASE 3, RANDOMIZED, DOUBLE-BLIND STUDY OF PF-05280586 VERSUS RITUXIMAB FOR THE FIRST-LINE TREATMENT OF PATIENTS WITH CD20-POSITIVE, LOW TUMOR BURDEN, FOLLICULAR LYMPHOMA
This study will compare the safety and effectiveness of PF-05280586 versus rituximab-EU in patients with CD20-positive, low tumor burden follicular lymphoma.
The primary hypothesis to be tested in this study is that the effectiveness of PF-05280586, as measured by the Overall Response Rate, is similar to that of rituximab-EU.
Panoramica dello studio
Stato
Completato
Condizioni
Intervento / Trattamento
Tipo di studio
Interventistico
Iscrizione (Effettivo)
394
Fase
- Fase 3
Contatti e Sedi
Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.
Luoghi di studio
-
-
-
Linz, Austria, 4010
- Krankenhaus Der Barmherzigen Schwestern Linz
-
Linz, Austria, 4020
- Kepler Universitaetsklinikum GmbH
-
Linz, Austria, 4021
- Kepler Universitaetsklinikum GmbH
-
-
-
-
-
Brussels, Belgio, 1070
- Hopital Erasme
-
Brussels, Belgio, 1200
- Nuclear Medicine Department
-
Charleroi, Belgio, 6000
- Grand Hopital de Charleroi-Site Notre-Dame
-
Charleroi, Belgio, 6000
- PET/CT facility: Grand Hopital de Charleroi (GHdC) - site Notre-Dame
-
Charleroi, Belgio, 6000
- Pharmacy Department: Grand Hopital de Charleroi (GHdC) - site Notre-Dame
-
La Louviere (Haine-Saint Paul), Belgio, 7100
- Pharmacy Department, Centre Hospitalier De Jolimont - Lobbes
-
La Louviere (Haine-Saint-Paul), Belgio, 7100
- Centre Hospitalier de Jolimont - Lobbes
-
La Louviere (Haine-Saint-Paul), Belgio, 7100
- Radiology Department
-
Mons, Belgio, 7000
- C.H.U. Ambroise Paré
-
Mons, Belgio, 7000
- Pharmacy Department, CHU Ambroise Pare
-
-
-
-
-
Brest, Bielorussia, 224027
- Healthcare Institution "Brest Regional Oncologic Dispensary"
-
Minsk, Bielorussia, 220013
- Healthcare Institution 'Minsk City Clinical Oncology Dispensary'
-
Republic Of Belarus, Bielorussia, 223040
- SI Republican Research and Practice Centre of oncology and medical radiology n.a N.N Alexandrov
-
-
Minsk Region
-
Lesnoy, Minsk Region, Bielorussia, 220013
- SI 'Republican Research and Practice Centre of Oncology and Medical Radiology n.a. N.N. Alexandrov'
-
Lesnoy, Minsk Region, Bielorussia, 223040
- SI 'Republican Research and Practice Centre of Oncology and Medical Radiology n.a. N.N. Alexandrov'
-
-
-
-
-
Sao Paulo, Brasile, 01236-030
- IEP Sao Lucas - Instituto de Ensino e Pesquisa Sao Lucas / HEMOMED - Instituto de Oncologia e
-
Sao Paulo, Brasile, 01333-910
- Fleury
-
-
Bahia
-
Salvador, Bahia, Brasile, 40050-410
- Hospital Santa Izabel - Setor de Bioimagem
-
Salvador, Bahia, Brasile, 40050-410
- Hospital Santa Izabel / Santa Casa de Misericordia da Bahia
-
-
GO
-
Goiania, GO, Brasile, 74175-150
- Clinica Multimagem
-
Goiania, GO, Brasile, 74605-020
- Hospital das Clinicas da Universidade Federal de Goias \ Centro de Pesquisa Clinica
-
-
MG
-
Belo Horizonte, MG, Brasile, 30130-100
- Centro de Imagens da Faculdade de Medicina - INCT Medicina Nuclear - PET/CT
-
Belo Horizonte, MG, Brasile, 30130-100
- Unidade Funcional Apoio Diagnostico e terapeutica por Imagem do HC/UFMG - CT Scan
-
-
Minas Gerais
-
Belo Horizonte, Minas Gerais, Brasile, 30130-100
- Hospital das Clinicas Universidade Federal de Minas Gerais
-
-
RIO Grande DO SUL
-
Porto Alegre, RIO Grande DO SUL, Brasile, 90035-903
- Hospital de Clinicas de Porto Alegre
-
Porto Alegre, RIO Grande DO SUL, Brasile, 90035-903
- Central de Misturas Intravenosas do Hospital de Clinicas de Porto Alegre
-
Porto Alegre, RIO Grande DO SUL, Brasile, 90035-903
- Hospital de Clinicas de Porto Alegre - Centro de Pesquisa Clinica
-
Porto Alegre, RIO Grande DO SUL, Brasile, 90035-903
- Servico de Radiologia do Hospital de Clinicas de Porto Alegre
-
-
RS
-
Porto Alegre, RS, Brasile, 90610-000
- CDI - Centro de Diagnostico por Imagem do Hospital Sao Lucas da PUCRS
-
Porto Alegre, RS, Brasile, 90610-000
- InsCer - Instituto do Cerebro do Rio Grande do Sul - PUCRS
-
Porto Alegre, RS, Brasile, 90610-000
- Uniao Brasileira de Educacao e Assistencia (UBEA) - Hospital Sao Lucas da PUCRS -
-
-
SAO Paulo
-
Jau, SAO Paulo, Brasile, 17210-080
- Fundacao Amaral Carvalho / Fundacao Dr. Amaral Carvalho
-
Jau, SAO Paulo, Brasile, 17210-120
- Fundacao Amaral Carvalho / Fundacao Dr. Amaral Carvalho
-
Jaú, SAO Paulo, Brasile, 17210-120
- Unidade de Quimioterapia
-
Santo Andre, SAO Paulo, Brasile, 09030-340
- Casa da Esperanca
-
Sao Bernardo do Campo, SAO Paulo, Brasile, 09750-670
- TECNOLAB
-
-
SP
-
Campinas, SP, Brasile, 13075-460
- CEMEDI
-
Campinas, SP, Brasile, 13075-460
- Instituto Radium
-
Campinas, SP, Brasile, 13087-567
- CAEP - Centro Avancado de Estudos e Pesquisas LTDA
-
Campinas, SP, Brasile, 13087-567
- Hospital e Maternidade Madre Theodora LTDA
-
Campinas, SP, Brasile, 13092-132
- CENNI Oncologia
-
Santo Andre, SP, Brasile, 09060-650
- Fundacao do ABC - FMABC/ Faculdade de Medicina ABC ( CEPHO - Centro de Estudos e Pesquisas de
-
Sao Paulo, SP, Brasile, 01506-000
- Hospital Bandeirantes
-
Sao Paulo, SP, Brasile, 05403-000
- Hospital das Clinicas da Faculdade de Medicina da USP / Fundacao Faculdade de Medicina MEC MPAS
-
Sao Paulo, SP, Brasile, 08270-070
- Casa de Saude Santa Marcelina (Centro de Pesquisa Santa Marcelina)
-
São Paulo, SP, Brasile, 01242-020
- IEP São Lucas (Pharmacy)
-
-
-
-
-
Busan, Corea, Repubblica di, 47392
- Inje University Busan Paik Hospital
-
Seoul, Corea, Repubblica di, 03080
- Seoul National University Hospital
-
Seoul, Corea, Repubblica di, 06351
- Samsung Medical Center
-
-
Gyeonggi-do
-
Anyang-si, Gyeonggi-do, Corea, Repubblica di, 14068
- Hallym University Sacred Heart Hospital
-
Seongnam-si, Gyeonggi-do, Corea, Repubblica di, 463-707
- Seoul National University Bundang Hospital
-
-
Jeollabuk-do
-
Jeonju-si, Jeollabuk-do, Corea, Repubblica di, 54907
- Chonbuk National University Hospital
-
-
Korea
-
Ulsan, Korea, Corea, Repubblica di, 44033
- Ulsan University Hospital
-
-
-
-
-
Zagreb, Croazia, 10000
- University Hospital Centre Zagreb
-
Zagreb, Croazia, 10 000
- University Hospital Center Zagreb, Department of Nuclear Medicine and Radiation Protection
-
Zagreb, Croazia, 10 000
- University Hospital Center Zagreb, Department of Pathology and Cytology
-
Zagreb, Croazia, 10 000
- University Hospital Center Zagreb, Department of Radiology
-
Zagreb, Croazia, 10000
- University Hospital Centre "Sestre Milosrdnice"
-
-
-
-
-
Chelyabinsk, Federazione Russa, 454087
- "State Budget Healthcare Institution ""Chelyabinsk Regional Clinical Center of Oncology
-
Moscow, Federazione Russa, 121309
- LLC "Vitamed"
-
Moscow, Federazione Russa, 115478
- FSBSI 'N.N.Blokhin Russian Cancer Research Center' of MoH of RF
-
Moscow, Federazione Russa, 115478
- Russian Cancer Research Centre them N.N. Blokhin
-
Moscow, Federazione Russa, 125284
- SBHI of Moscow City Clinical Hospital n.a. S.P.Botkin of Healthcare Department of Moscow
-
Moscow, Federazione Russa, 127473
- Ramsay Diagnostics
-
Saint Petersburg, Federazione Russa, 194291
- State Budgetary Institution of Healthcare "Leningrad Regional Clinical Hospital"
-
Saint-Petersburg, Federazione Russa, 194214
- Dr. Berezin Medical Institute
-
Saint-Petersburg, Federazione Russa, 197376
- N.P. Bechtereva Institute of Human Brain of the Russian Academy of Sciences
-
Saint-Petersburg, Federazione Russa, 197376
- N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences
-
Saint-Petersurg, Federazione Russa, 195271
- Non-state healthcare institution "Road Clinical Hospital of Joint Stock Company "Russian Railways"
-
Yaroslavl, Federazione Russa, 150010
- Yaroslavl State Medical Academy
-
Yaroslavl, Federazione Russa, 150062
- GBUZ of Yaroslavl Region "Regional Clinical Hospital"
-
-
Kaluga Region
-
Obninsk, Kaluga Region, Federazione Russa, 249036
- A.Tsyb Medical Radiological Research Centre -
-
-
Mordovian Republic
-
Saransk, Mordovian Republic, Federazione Russa, 430032
- State Healthcare Institution Republican Oncology Dispensary
-
-
Nizhniy Novgorod Region
-
Nizhniy Novgorod, Nizhniy Novgorod Region, Federazione Russa, 603126
- "SBHI of NNR ""Nizhniy Novgorod Regional Clinical Hospital n.a. N.A. Semashko"""
-
Nizhniy Novgorod, Nizhniy Novgorod Region, Federazione Russa, 603126
- LLC MC "MRT-Diagnostika"
-
-
Pesochniy
-
Saint-Petersburg, Pesochniy, Federazione Russa, 197758
- FSBI "Russian Research Centre of Radiology and Surgical Technologies n.a. A.M. Granov" of MoH of RF
-
Saint-Petersburg, Pesochniy, Federazione Russa, 197758
- FSBI "Russian Research Centre of Radiology and Surgical Technologies named after academician
-
Saint-Petersburg, Pesochniy, Federazione Russa, 197758
- FSBI "Russian Research Centre of Radiology and Surgical Technologies
-
-
Pesochniy TOWN
-
Saint-Petersburg, Pesochniy TOWN, Federazione Russa, 197758
- FSBI "Russian Research Centre of Radiology and Surgical Technologies" of MoH of RF
-
Saint-Petersburg, Pesochniy TOWN, Federazione Russa, 197758
- FSBI "Russian Research Centre of Radiology and Surgical Technologies"
-
Saint-Petersburg, Pesochniy TOWN, Federazione Russa, 197758
- FSBI "Russian Research Centre of Radiology and Surgical Technologies
-
Saint-Petersburg, Pesochniy TOWN, Federazione Russa, 197758
- FSBI 'Russian Research Centre of Radiology and Surgical Technologies
-
-
Pos.pesochny
-
Saint-Petersburg, Pos.pesochny, Federazione Russa, 197758
- FSBI 'National Medical Oncology Research Centre n.a. N.N.Petrov'
-
-
Republic Bashkortostan
-
Ufa, Republic Bashkortostan, Federazione Russa, 450054
- Branch office of LLC 'PET-Technology' at Ufa city
-
Ufa, Republic Bashkortostan, Federazione Russa, 450054
- State Budgetary Healthcare Institution "Republican Clinical Oncology Dispensary of the Ministry
-
-
Saint Petersburg
-
Pushkin, Saint Petersburg, Federazione Russa, 196603
- Private Medical Institution "Euromedservice"
-
-
Saint-petersburg
-
Pesochniy Town, Saint-petersburg, Federazione Russa, 197758
- FSBI "Russian Research Centre of Radiology and Surgical Technologies" of MoH of RF
-
-
Stavropol Region
-
Lermontov, Stavropol Region, Federazione Russa, 357340
- Federal State-Financed Institution 'North-Caucasian Research and Clinical Center'
-
Pyatigorsk, Stavropol Region, Federazione Russa, 357502
- SBHI of Stavropol Region "Pyatigorsk Interdistrict Oncology Dispensary
-
-
-
-
-
Quezon City, Filippine, 1102
- St. Luke's Medical Center
-
-
Metro Manila
-
Manila, Metro Manila, Filippine, 1000
- University of Philippines Manila-Philippine General Hospital
-
-
-
-
-
Boulogne Sur Mer, Francia, 62321
- Hopital Duchenne Chu - Boulogne Sur Mer
-
Bourg En Bresse Cedex, Francia, 01012
- Centre Hospitalier de Bourg en Bresse
-
Brest, Francia, 29609
- Hopital Morvan-CHU Brest- Service Hematologie Clinique
-
Caen, Francia, 14033
- Centre Hospitalier Universitaire Côte de Nacre
-
Le Mans, Francia, 72037
- Centre Hospitalier du Mans
-
Lyon, Francia, 69009
- Clinique de la Sauvegarde
-
-
Marseille Cedex 05
-
Marseille, Marseille Cedex 05, Francia, 13385
- CHU Marseille Hopital de La Conception
-
-
Mulhouse Cedex
-
Mulhouse, Mulhouse Cedex, Francia, 68100
- CH de Mulhouse, Hopital Emile Muller
-
-
NAP
-
Boulogne Sur Mer, NAP, Francia, 62321
- Hopital Duchenne Chu - Boulogne Sur Mer
-
-
-
-
-
Tbilisi, Georgia, 0144
- High Technology Medical Center, University Clinic
-
Tbilisi, Georgia, 0112
- "LTD ""M. Zodelava's Hematology Centre"""
-
Tbilisi, Georgia, 0112
- LTD "Research Institute of Clinical Medicine"
-
-
-
-
-
Berlin, Germania, 13353
- Charité - Universitätsmedizin Berlin
-
Berlin, Germania, 12200
- Charite - Universitaetsmedizin Berlin
-
Berlin, Germania, 12200
- Charité - Universitätsmedizin Berlin - Campus Benjamin Franklin
-
Berlin, Germania, 13353
- Charite - Universitaetsmedizin Berlin, Campus Virchow-Klinikum
-
Berlin, Germania, 13353
- Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum
-
Chemnitz, Germania, 09113
- Klinikum Chemnitz gGmbH
-
Chemnitz, Germania, 09113
- Klinikum Chemnitz gGmbH - Institut fuer Interventionelle Radiologie und Neuroradiologie
-
Chemnitz, Germania, 09116
- Klinikum Chemnitz gGmbH - Klinik fuer Nuklearmedizin
-
Chemnitz, Germania, 09116
- Klinikum Chemnitz gGmbH - Zentralapotheke
-
Essen, Germania, 45147
- Universitaetsklinikum Essen (AoeR)
-
Essen, Germania, 45147
- Universitatsklinikum Essen (Aor)
-
Herne, Germania, 44623
- DokuSan Gesellschaft fuer Medizinische Studien mbH & Co. KG
-
Herne, Germania, 44649
- Apotheke des St. Anna Hospital
-
Herne, Germania, 44651
- EVK Eickel
-
Koeln, Germania, 50679
- Praxis im Koeln Triangle
-
Mutlangen, Germania, 73557
- Gemeinschaftspraxis fuer Diagnostische Radiologie und Nuklearmedizin
-
Mutlangen, Germania, 73557
- Kliniken Ostalb, Stauferklinikum Schwaebisch Gmuend, Zentrum fuer Innere Medizin
-
Mutlangen, Germania, 73557
- Stauferklinikum Schwaebisch Gmuend, Apotheke
-
Rostock, Germania, 18057
- Universitaetsmedizin Rostock
-
Stuttgart, Germania, 70174
- Klinikum Stuttgart, Klinik fuer Nuklearmedizin
-
Stuttgart, Germania, 70199
- Vinzenz von Paul Kliniken GgmbH
-
Troisdorf, Germania, 53840
- Radiologie Rhein-Sieg
-
Troisdorf, Germania, 53840
- Ueberoertliche Berufsausuebungsgemeinschaft Drs. med. Helmut Forstbauer
-
Troisdorf, Germania, 53842
- Zentralapotheke
-
-
-
-
-
Fukuoka, Giappone, 811-0213
- Fukuoka Wajiro PET Diagnostic Imaging Clinic
-
Nagano, Giappone, 399-8701
- National Hospital Organization Matsumoto Medical Center
-
Tokyo, Giappone, 2080022
- Musashimurayama Hospital
-
-
Aichi
-
Nagoya, Aichi, Giappone, 466-8650
- Nagoya Daini Red Cross Hospital
-
Nagoya, Aichi, Giappone, 464-0044
- East Nagoya Imaging Diagnosis Center
-
-
Akita
-
Akita City, Akita, Giappone, 010-8543
- Akita University Hospital
-
-
Chiba
-
Chiba-shi, Chiba, Giappone, 260-8717
- Chiba Cancer Center
-
-
Fukuoka
-
Fukuoka-Shi, Fukuoka, Giappone, 811-1395
- National Hospital Organization Kyushu Cancer Center
-
Fukuoka-shi, Fukuoka, Giappone, 810-8563
- National Hospital Organization Kyushu Medical Center
-
-
Hyogo
-
Kobe-City, Hyogo, Giappone, 650-0047
- Kobe City Medical Center General Hospital
-
-
Ishikawa
-
Kanazawa, Ishikawa, Giappone, 920-8650
- National Hospital Organization Kanazawa Medical Center
-
Kanazawa, Ishikawa, Giappone, 9200934
- Kanazawa Advanced Medical Center
-
-
Kanagawa-ken
-
Yokohama-shi, Kanagawa-ken, Giappone, 224-8503
- Showa University Northern Yokohama Hospital
-
-
Kochi
-
Okocho, Nankoku, Kochi, Giappone, 783-8505
- Kochi Medical School Hospital
-
-
Kumamoto-ken
-
Kumamoto-shi, Kumamoto-ken, Giappone, 860-0008
- National Hospital Organization Kumamoto Medical Center
-
Kumamoto-shi, Kumamoto-ken, Giappone, 862-0941
- Uozumi Clinic
-
-
Miyagi
-
Sendai-shi, Miyagi, Giappone, 983-8520
- National Hospital Organization Sendai Medical Center
-
Sendai-shi, Miyagi, Giappone, 980-0873
- Sendai Kousei Hospital
-
-
Nagano
-
Matsumoto-shi, Nagano, Giappone, 390-8510
- Aizawa Hospital
-
Nagano-shi, Nagano, Giappone, 380-8582
- Nagano Red Cross Hospital
-
-
Nagasaki
-
Omura, Nagasaki, Giappone, 856-8562
- National Hospital Organization Nagasaki Medical Center
-
-
Osaka
-
Kawachinagano, Osaka, Giappone, 586-8521
- National Hospital Organization Osaka Minami Medical Center
-
Naka-ku Sakai, Osaka, Giappone, 599-8271
- Hanwa Dai 2 Senboku Hospital
-
Osaka-City, Osaka, Giappone, 545-8586
- Osaka City University Hospital
-
-
Tokushima
-
Tokushima-Shi, Tokushima, Giappone, 770-8503
- Tokushima University Hospital
-
-
Tokyo
-
Meguro-Ku, Tokyo, Giappone, 152-8902
- National Hospital Organization Tokyo Medical Center
-
Shinagawa-ku, Tokyo, Giappone, 142-8666
- Showa University Hospital
-
Tachikawa, Tokyo, Giappone, 190-0014
- National Hospital Organization Disaster Medical Center
-
-
Yamagata
-
Yamagata-Shi, Yamagata, Giappone, 990-9585
- Yamagata University Hospital
-
-
-
-
-
Athens, Grecia, 10676
- Gen. Hosp. of Athens "Evangelismos - Eye Hosp.- Polikliniki"
-
Athens, Grecia, 10676
- Gen. Hosp. of Athens "Evangelismos-Eye Hosp. - Polikliniki"
-
Athens, Grecia, 10676
- Gen. Hosp. of Athens "Evangelismos-Eye Hosp.-Polikliniki"
-
Athens, Grecia, 10676
- Gen.Hosp.of Athens "Evangelismos-Eye Hosp.-polikiliniki"
-
Athens, Grecia, 10676
- General Hospital of Athens "Evangelismos - Eye Hosp. - Polikliniki"
-
Athens, Grecia, 11526
- Bioiatriki S.A.
-
Athens, Grecia, 11526
- Bioiatriki
-
Athens, Grecia, 11527
- General Hospital of Athens 'Laiko'
-
Athens, Grecia, 12462
- """ATTIKON"" Gen. Univ. Hosp"
-
Chaidari, Athens, Grecia, 12462
- "ATTIKON'' Gen. Univ. Hosp.
-
Patras, Grecia, 26504
- University General Hospital of Patras
-
Patras, Grecia, 26222
- Magnitiki Patron
-
-
-
-
-
New Delhi, India, 110 085
- Rajiv Gandhi Cancer Institute & Research Center (RGCIRC)
-
-
Gujarat
-
Surat, Gujarat, India, 395001
- Super Scan Imaging Centre
-
Surat, Gujarat, India, 395002
- Pathology Department, Unique Hospital Multispeciality & Research Institute
-
Surat, Gujarat, India, 395002
- Zircon- BIC Imaging Centre
-
-
Karanataka
-
Mangalore, Karanataka, India, 575002
- Mangalore Institute of Oncology
-
-
Karnataka
-
Bangalore, Karnataka, India, 560027
- HealthCare Global Enterprises Limited
-
Manipal, Karnataka, India, 576104
- Kasturba Medical College and Hospital
-
-
Maharashtra
-
Nashik, Maharashtra, India, 422004
- Curie Manavata Cancer Centre
-
Nashik, Maharashtra, India, 422004
- Department of Radiology, Curie Manavata Cancer Centre
-
Pune, Maharashtra, India, 411001
- Ruby Hall Clinic
-
Pune, Maharashtra, India, 411001
- Department of Radiology
-
Pune, Maharashtra, India, 411001
- Jehangir Clinical Development Centre Pvt. Ltd.
-
-
Rajasthan
-
Jaipur, Rajasthan, India, 302004
- R.K. Birla Cancer Center, Sawai Man Singh Hospital
-
-
Tamilnadu
-
Chennai, Tamilnadu, India, 600035
- Apollo Speciality Hospital
-
Chennai, Tamilnadu, India, 600035
- Department of Radiology
-
-
Telangana
-
Hyderabad, Telangana, India, 500 004
- Global Hospitals
-
Hyderabad, Telangana, India, 500029
- Vijaya Diagnostic Centre
-
-
WEST Bengal
-
Kolkata, WEST Bengal, India, 700014
- N.R.S Medical College and Hospital
-
Kolkata, WEST Bengal, India, 700014
- Spandan PET-CT Unit
-
-
-
-
-
Genova, Italia, 16132
- IRCSS A.O.U. San Martino - IST - UO Clinica Ematologica
-
Milano, Italia, 20133
- SC Ematologia, Fondazione IRCCS Ist Nazionale dei Tumori
-
Parma, Italia, 43100
- Padiglione 1, Torre delle medicine, 6 piano
-
Pesaro, Italia, 61122
- Ematologia e Centro Trapianti - AZ Osp. Ospedali Riuniti Marche Nord (AORMN) - Presidio S. Salvatore
-
Pisa, Italia, 56126
- U.O. Ematologia Universitaria - Dip. Di Oncologia dei Trapianti - AOU Pisana
-
Roma, Italia, 00128
- Policlinico Universitario Campus Bio- Medico-U.O.C. di Ematologia Trapianto Cellule Staminali
-
-
CR
-
Cremona, CR, Italia, 26100
- U.O. di Ematologia e CTMO - Istituti Ospedalieri di Cremona
-
-
FC
-
Meldola, FC, Italia, 47014
- IRST - IRCCS U. O. Oncologia Medica
-
-
GE
-
Genova, GE, Italia, 16132
- U.O. Ematologia 1 - IRCCS AOU San Martino-IST
-
-
MB
-
Monza, MB, Italia, 20900
- Unita di Ricerca Clinica
-
-
MI
-
Milano, MI, Italia, 20141
- Istituto Europeo di Oncologia
-
-
NAP
-
Latina, NAP, Italia, 04100
- Unità semplice di Medicina Nucleare
-
-
PG
-
Terni, PG, Italia, 05100
- Az Ospedaliera Santa Maria
-
-
Palermo
-
Torrette Ancona, Palermo, Italia, 60121
- Clinica Ematologica - A.O.U. Ospedali Riuniti di Ancona
-
-
Reggio
-
Reggio Emilia, Reggio, Italia, 42123
- Medicina nucleare
-
Reggio Emilia, Reggio, Italia, 42123
- Radiologia
-
Reggio Emilia, Reggio, Italia, 42123
- SC Ematologia - SC Ematologia - Arcispedale Santa Maria Nuova - IRCCS
-
-
Rome Rm
-
Rome, Rome Rm, Italia, 00161
- "Dipartimento di Biotecnologie Cellulari ed Ematologia, Universita ""Sapienza""
-
-
-
-
-
Beirut, Libano
- Doctors Center Radiology
-
Beirut, Libano
- Mount Lebanon Hospital
-
El Metn, Libano
- Middle East Institute Of Health
-
Mount Lebanon, Libano
- Ain Wazein Hospital
-
-
Southern Governate
-
Saida, Southern Governate, Libano
- Hammoud Hospital, University Medical Center
-
-
-
-
-
Oaxaca, Messico, 68000
- Oaxaca Site Management Organization S.C.
-
Oaxaca, Messico, 68000
- Cirurgia y Ginecobstetricia de Oaxaca, S.A de C.V.
-
Puebla, Messico, 72190
- Hospital Angeles Puebla
-
Queretaro, Messico, 76090
- Cancerologia de Queretaro S.C.
-
Queretaro, Messico, 76140
- Hospital Infantil Teleton de Oncologia
-
Queretaro, Messico, 76158
- Hospital San Jose Norte
-
-
Distrito Federal
-
Mexico City, Distrito Federal, Messico, 03310
- Grupo Médico Camino S.C.
-
Mexico City, Distrito Federal, Messico, 03340
- Imagenus
-
Mexico City, Distrito Federal, Messico, 06700
- Isos Pharmacorp, S.A. de C.V.
-
-
Estado DE Mexico
-
Cuautitlan Izacalli, Estado DE Mexico, Messico, 54750
- Vely Grupo Medico Quirurgico, S.A. de C.V.
-
Cuautitlan Izcalli, Estado DE Mexico, Messico, 54769
- Phylasis Clinicas Research S. de R.L. de C.V.
-
-
Nuevo LEON
-
Monterrey, Nuevo LEON, Messico, 64460
- Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
-
Monterrey, Nuevo LEON, Messico, 64460
- Centro Universitario de Imagen Diagnostica, Radiologia e Imagen del Hospital Universitario
-
-
-
-
-
Lima, Perù, 18
- Pet Scan Peru
-
Lima, Perù, 18
- Resocentro
-
-
Lima
-
Surquillo, Lima, Perù, 34
- Instituto Nacional de Enfermedades Neoplasicas
-
-
-
-
-
Warszawa, Polonia, 02-781
- Klinika Nowotworow Ukladu Chlonnego Centrum Onkologii - Instytut im. M. Sklodowskiej-Curie
-
Wroclaw, Polonia, 50-420
- Euromedic Wroclawskie Centrum Medyczne II
-
Wroclaw, Polonia, 50-557
- Euromedic Wroclawskie Centrum Medyczne III
-
Wroclaw, Polonia, 53-439
- Dolnośląskie Centrum Transplantacji Komórkowych z Krajowym Bankiem Dawców Szpiku
-
Wroclaw, Polonia, 53-439
- Euromedic Wroclawskie Centrum Medyczne I
-
Wroclaw, Polonia, 54-424
- Apteka Dolnoslaskiego Centrum Transplantacji Komorkowych z Krajowym Bankiem Dawcow Szpiku
-
-
-
-
-
Coto Laurel, Porto Rico, 00780
- Modern Radiology, PSC
-
Ponce, Porto Rico, 00717
- Ad-Vance Medical Research, LLC
-
Ponce, Porto Rico, 00717
- Caribe MRI and CT
-
-
-
-
-
Braga, Portogallo, 4710-243
- Hospital de Braga
-
Lisboa, Portogallo, 1998-018
- Hospital CUF Descobertas
-
Porto, Portogallo, 4050-075
- CIMC
-
Porto, Portogallo, 4050-075
- Dr. Campos Costa Clinic
-
Porto, Portogallo, 4099 - 001
- Centro Hospitalar do Porto-Hospital de Santo Antonio E.P.E.
-
Porto, Portogallo, 4200-072
- Instituto Portugues de Oncologia Do Porto Francisco Gentil E.P.E
-
Vila Nova de Gaia, Portogallo, 4434-502
- Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E.
-
-
Porto
-
Matosinhos, Porto, Portogallo, 4464-513
- Unidade Local de Saude de Matosinhos E.P.E. - Hospital Pedro Hispano S.A.
-
-
-
-
-
Bath, Regno Unito, BA1 3NG
- Royal United Hospitals Bath NHS Foundation Trust
-
London, Regno Unito, EC1A 7BE
- Barts Health NHS Trust
-
Newcastle upon Tyne, Regno Unito, NE4 6BE
- Positron Emission Tomography (PET) Centre
-
Sunderland, Regno Unito, SR4 7TP
- City Hospitals Sunderland NHS Foundation Trust-Sunderland Royal Hospital
-
Sunderland, Regno Unito, SR4 7TP
- Diagnostic Imaging
-
-
Essex
-
Westcliff-On-Sea, Essex, Regno Unito, SS0 0RY
- Southend University Hospital NHS Foundation Trust
-
-
Glos.
-
Cheltenham, Glos., Regno Unito, GL53 7AS
- Cobalt Diagnostic Imaging
-
-
-
-
-
Brasov, Romania, 500152
- Policlinica de Diagnostic Rapid, Hematologie
-
Brasov, Romania, 500366
- Policlinica de Diagnostic Rapid SA
-
Bucuresti, Romania, 030171
- Spitalul Clinic Coltea, Clinica de Hematologie
-
Bucuresti, Romania, 020125
- Spitalul Clinic Colentina
-
Bucuresti, Romania, 021675
- Hiperdia Ritmului
-
Bucuresti, Romania, 022328
- Affidea Fundeni
-
Bucuresti, Romania, 022328
- Affidea Romania SRL
-
Cluj-Napoca, Romania, 400015
- Institutul Oncologic Prof. Dr. Ion Chiricuta, Laborator Radiologie si Imagistica Medicala
-
Cluj-Napoca, Romania, 400015
- Institutul Oncologic Prof. Dr. Ion Chiricuta, Sectia Oncologie Medicala
-
Cluj-Napoca, Romania, 400124
- Clinica de Hematologie-Institutul Oncologic, Prof. Dr. Ion Chiricuta
-
Cluj-Napoca, Romania, 400489
- CT Clinic S.R.L.
-
-
-
-
-
A Coruna, Spagna, 15006
- Complejo Hospitalario Universitario A Coruña
-
A Coruna, Spagna, 15011
- Hospital Modelo
-
Barcelona, Spagna, 08003
- Hospital Del Mar
-
Barcelona, Spagna, 08012
- Hospital Quiron de Barcelona, IEC
-
Barcelona, Spagna, 08029
- CETIR, Centre Medic
-
Barcelona, Spagna, 08029
- Radiodiagnostic CETIR - Clinica del Pilar
-
Cadiz, Spagna, 11009
- Hospital Universitario Puerta del Mar
-
Madrid, Spagna, 28040
- Hospital Universitario Fundación Jiménez Díaz
-
Madrid, Spagna, 28050
- Hospital Universitario Sanitas La Moraleja
-
Malaga, Spagna, 29010
- Hospital Universitario Virgen de la Victoria
-
Malaga, Spagna, 29010
- Centro CIMES
-
Malaga, Spagna, 29016
- Centro Mario Gallegos
-
Ourense, Spagna, 32005
- Complejo Hospitalario de Ourense. Hematología
-
Sevilla, Spagna, 41013
- Hospital Universitario Virgen del Rocío
-
Zaragoza, Spagna, 50012
- Hospital de Dia Quiron Zaragoza
-
Zaragoza, Spagna, 50006
- H. Quirón Zaragoza
-
-
Barcelona
-
Sabadell, Barcelona, Spagna, 08208
- Hospital Parc Tauli
-
-
Guipuzcoa
-
San Sebastian, Guipuzcoa, Spagna, 20014
- Onkologikoa
-
-
Madrid
-
Aravaca, Madrid, Spagna, 28023
- Hospital Universitario Sanitas la Zarzuela
-
Mostoles, Madrid, Spagna, 28933
- Hospital Rey Juan Carlos
-
-
Murcia
-
El Palmar, Murcia, Spagna, 30120
- Hospital Clínico Universitario Virgen de la Arrixaca
-
-
Pontevedra
-
Vigo, Pontevedra, Spagna, 36200
- Hospital do Meixoeiro Complejo Hospitalario Universitario de Vigo
-
-
-
-
California
-
Anaheim, California, Stati Uniti, 92801
- Pacific Cancer Medical Center, Inc.
-
Anaheim, California, Stati Uniti, 92801
- The Oncology Institute of Hope and Innovation
-
Corona, California, Stati Uniti, 92879
- Compassionate Care Research Group, Inc., at Compassionate Cancer Care Medical Group, Inc.
-
Downey, California, Stati Uniti, 90241
- The Oncology Institute of Hope and Innovation
-
Fountain Valley, California, Stati Uniti, 92708
- Compassionate Care Research Group, Inc., at Compassionate Cancer Care Medical Group, Inc.
-
Gilroy, California, Stati Uniti, 95020
- Global Cancer Research Institute (GCRI), Inc
-
Gilroy, California, Stati Uniti, 95020
- Saint Louise Regional Hospital Radiology Department (Radiology Only)
-
Gilroy, California, Stati Uniti, 95020
- South Valley Imaging Center (Imaging Only)
-
Glendale, California, Stati Uniti, 91204
- Los Angeles Hematology Oncology Medical Group
-
Glendale, California, Stati Uniti, 91204
- The Oncology Institute of Hope and Innovation
-
Glendale, California, Stati Uniti, 91206
- Los Angeles Hematology Oncology Medical Group
-
Long Beach, California, Stati Uniti, 90805
- The Oncology Institute of Hope and Innovation
-
Los Angeles, California, Stati Uniti, 90017
- Los Angeles Hematology Oncology Medical Group
-
Los Angeles, California, Stati Uniti, 90057
- Los Angeles Hematology Oncology Medical Group
-
Lynwood, California, Stati Uniti, 90262
- The Oncology Institute of Hope and Innovation
-
Montebello, California, Stati Uniti, 90640
- The Oncology Institute of Hope and Innovation
-
Palm Springs, California, Stati Uniti, 92262
- Comprehensive Cancer Center at Desert Regional Medical Center
-
Redondo Beach, California, Stati Uniti, 90277
- Torrance Health Association DBA, Torrance Memorial Physician, Network/Cancer Care Associates
-
Riverside, California, Stati Uniti, 92501
- Compassionate Care Research Group, Inc., at Compassionate Cancer Care Medical Group, Inc.
-
San Jose, California, Stati Uniti, 95128
- O'Connor Hospital
-
San Jose, California, Stati Uniti, 95124
- Global Cancer Research Institute, Inc.
-
San Jose, California, Stati Uniti, 95128
- PET Imaging of San Jose (Imaging Only)
-
Santa Ana, California, Stati Uniti, 92705
- The Oncology Institute of Hope and Innovation
-
Torrance, California, Stati Uniti, 90505
- Torrance Memorial Medical Center
-
Whittier, California, Stati Uniti, 90603
- Innovative Clinical Research Institute (ICRI)
-
Whittier, California, Stati Uniti, 90602
- The Oncology Institute of Hope and Innovation
-
-
Colorado
-
Aurora, Colorado, Stati Uniti, 80012
- Rocky Mountain Cancer Centers
-
Boulder, Colorado, Stati Uniti, 80303
- Rocky Mountain Cancer Centers
-
Denver, Colorado, Stati Uniti, 80218
- Rocky Mountain Cancer Centers
-
Lakewood, Colorado, Stati Uniti, 80228
- Rocky Mountain Cancer Center-Lakewood (Laboratory)
-
Lakewood, Colorado, Stati Uniti, 80228
- Rocky Mountain Cancer Centers (RMCC) - Lakewood - St Anthony
-
Lone Tree, Colorado, Stati Uniti, 80124
- Rocky Mountain Cancer Centers
-
Pueblo, Colorado, Stati Uniti, 81008
- Rocky Mountain Cancer Center Pueblo
-
-
Georgia
-
Thomasville, Georgia, Stati Uniti, 31792
- John D. Archbold Memorial Hospital
-
Thomasville, Georgia, Stati Uniti, 31792
- Lewis Hall Singletary Oncology Center at John D. Archbold Memorial Hospital
-
-
Illinois
-
DeKalb, Illinois, Stati Uniti, 60115
- Northwestern Medicine West Region
-
Geneva, Illinois, Stati Uniti, 60134
- Cancer Center,Northwestern Medicine, West Region
-
-
Kansas
-
Chanute, Kansas, Stati Uniti, 66720
- Cancer Center of Kansas
-
Dodge City, Kansas, Stati Uniti, 67801
- Cancer Center of Kansas
-
El Dorado, Kansas, Stati Uniti, 67042
- Cancer Center of Kansas
-
Independence, Kansas, Stati Uniti, 67301
- Cancer Center of Kansas
-
Kingman, Kansas, Stati Uniti, 67068
- Cancer Center of Kansas
-
Liberal, Kansas, Stati Uniti, 67905
- Cancer Center of Kansas
-
McPherson, Kansas, Stati Uniti, 67460
- Cancer Center of Kansas
-
Newton, Kansas, Stati Uniti, 67114
- Cancer Center of Kansas
-
Overland Park, Kansas, Stati Uniti, 66210
- The University of Kansas Cancer Center
-
Parsons, Kansas, Stati Uniti, 67357
- Cancer Center of Kansas
-
Salina, Kansas, Stati Uniti, 67401
- Cancer Center of Kansas
-
Wellington, Kansas, Stati Uniti, 67152
- Cancer Center of Kansas
-
Wichita, Kansas, Stati Uniti, 67214
- Cancer Center of Kansas
-
Wichita, Kansas, Stati Uniti, 67208
- Cancer Center of Kansas
-
Winfield, Kansas, Stati Uniti, 67156
- Cancer Center of Kansas
-
-
Maryland
-
Baltimore, Maryland, Stati Uniti, 21229
- Saint Agnes Hospital
-
Baltimore, Maryland, Stati Uniti, 21229
- PET/CT facility Seton Imaging Center
-
Bethesda, Maryland, Stati Uniti, 20817
- Rcca Md Llc
-
Silver Spring, Maryland, Stati Uniti, 20910
- Holy Cross Hospital
-
Silver Spring, Maryland, Stati Uniti, 20902
- Holy Cross Hospital Resource Center
-
Silver Spring, Maryland, Stati Uniti, 20910
- Holy Cross Hospital Hospital Pharmacy
-
Wheaton, Maryland, Stati Uniti, 20902
- Maryland Oncology Hematology, P.A.
-
-
Missouri
-
Kansas City, Missouri, Stati Uniti, 64131
- The University of Kansas Cancer Center
-
Kansas City, Missouri, Stati Uniti, 64154
- The University of Kansas Cancer Center
-
Lee's Summit, Missouri, Stati Uniti, 64064
- The University of Kansas Cancer Center
-
-
Nebraska
-
Grand Island, Nebraska, Stati Uniti, 68803
- Saint Francis Medical Center, Saint Francis Cancer Treatment Center
-
Grand Island, Nebraska, Stati Uniti, 68803
- Saint Francis Medical Center
-
Hastings, Nebraska, Stati Uniti, 68901
- Saint Francis Medical Center, Saint Francis Cancer Treatment Center
-
-
Nevada
-
Henderson, Nevada, Stati Uniti, 89074
- Comprehensive Cancer Centers of Nevada
-
Henderson, Nevada, Stati Uniti, 89052
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Stati Uniti, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Stati Uniti, 89128
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Stati Uniti, 89169
- Comprehensive Cancer Centers of Nevada
-
-
North Carolina
-
Greenville, North Carolina, Stati Uniti, 27834
- Vidant Medical Center
-
Greenville, North Carolina, Stati Uniti, 27834
- Brody School of Medicine at East Carolina University
-
Greenville, North Carolina, Stati Uniti, 27834
- Vidant Medical Center Pharmacy
-
-
Ohio
-
Maumee, Ohio, Stati Uniti, 43537
- Toledo Clinic Cancer Center - Maumee
-
Toledo, Ohio, Stati Uniti, 43623
- Toledo Clinic Cancer Center - Toledo
-
Toledo, Ohio, Stati Uniti, 43623
- Toledo Clinic, Inc.
-
-
Oregon
-
Eugene, Oregon, Stati Uniti, 97401
- Willamette Valley Cancer Institute and Research Center
-
-
Tennessee
-
Knoxville, Tennessee, Stati Uniti, 37920
- University of Tennessee Medical Center
-
-
Texas
-
Fort Sam Houston, Texas, Stati Uniti, 78234
- San Antonio Military Medical Center
-
Fort Sam Houston, Texas, Stati Uniti, 78234
- San Antonio Military Medical Center- Department of Pharmacy
-
Fort Sam Houston, Texas, Stati Uniti, 78234
- San Antonio Military Medical Center- Department of Radiology
-
Fort Worth, Texas, Stati Uniti, 76177
- Investigational Products Center (IPC)
-
Fort Worth, Texas, Stati Uniti, 76177
- Investigational Products Center (I PC)
-
Houston, Texas, Stati Uniti, 77090
- Millennium Oncology
-
Irving, Texas, Stati Uniti, 75063
- US Oncology Investigational Products Center (IPC)
-
Kingwood, Texas, Stati Uniti, 77339
- Millennium Oncology
-
Longview, Texas, Stati Uniti, 75601
- Texas Oncology - Longview Cancer Center
-
Shenandoah, Texas, Stati Uniti, 77384
- Millennium Oncology
-
The Woodlands, Texas, Stati Uniti, 77380
- Millennium Oncology
-
Tyler, Texas, Stati Uniti, 75702
- Texas Oncology-Tyler
-
-
Washington
-
Yakima, Washington, Stati Uniti, 98902
- Yakima Valley Memorial Hospital/North Star Lodge Cancer Center
-
-
-
-
Gauteng
-
Groenkloof, Gauteng, Sud Africa, 0181
- NIKSCH & PARTNERS t/a CAPITAL RADIOLOGY
-
Johannesburg, Gauteng, Sud Africa, 2196
- The Medical Oncology Centre of Rosebank
-
Pretoria, Gauteng, Sud Africa, 0002
- Department of Medical Oncology, University of Pretoria, Steve Biko Academic Hospitals Complex
-
Pretoria, Gauteng, Sud Africa, 0044
- Albert Alberts Stem Cell Transplant Centre
-
Pretoria, Gauteng, Sud Africa, 0044
- Dr JN De Jong and Partners t/a East Rad
-
Pretoria, Gauteng, Sud Africa, 0181
- NIKSCH & PARTNERS t/a CAPITAL RADIOLOGY
-
Rosebank, Gauteng, Sud Africa, 2196
- Drs Sulman & Partners Specialist Radiologists
-
Sandton, Gauteng, Sud Africa, 2191
- Drs Bloch & Partners Incorporated
-
-
-
-
-
Basel, Svizzera, 4031
- Universitätsspital Basel
-
Bern, Svizzera, 3010
- Inselspital Bern
-
Thun, Svizzera, 3600
- Apotheke, Spital STS AG
-
Thun, Svizzera, 3600
- Onkologiezentrum Thun-Berner Oberland Spital Sts Ag
-
Zuerich, Svizzera, 8091
- Universitaetsspital Zuerich
-
Zuerich, Svizzera, 8006
- Kantonsapotheke Zuerich
-
-
-
-
-
Ankara, Tacchino, 06100
- Hacettepe Universitesi Tip Fakultesi Onkoloji Hastanesi
-
Ankara, Tacchino, 06200
- Dr. Abdurrahman Yurtaslan Ankara Onkoloji Eg. ve Aras.
-
Ankara, Tacchino, 06420
- Ultramar Tibbi Gorunteleme Merkezi
-
Ankara, Tacchino, 06420
- Ultramar Tibbi Goruntuleme Merkezi
-
Ankara, Tacchino, 06540
- Integra Gurses Teshis Tedavi ve Saglik Hizmetleri A.S.
-
Aydin, Tacchino, 09010
- Adnan Menderes University Medical Faculty
-
Gaziantep, Tacchino, 27310
- Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi
-
Gaziantep, Tacchino, 27310
- Gaziantep Universitesi Sahinbey Arastirma ve Uygulama
-
Istanbul, Tacchino, 34093
- Bezmialem Vakif Universitesi Tip Fakultesi Hastanesi
-
Izmir, Tacchino, 35040
- Ege Universitesi Tip Fakultesi Ic Hastaliklari Anabilim Dali
-
Izmir, Tacchino, 35040
- EGE-RAD Bilgisayarli Tomografi Ozel Saglik Hizmetleri ve Malzemeleri Tic.Ltd.Sti.
-
Kayseri, Tacchino, 38100
- Erciyes Universitesi Tip Fakultesi Nukleer Tip Laboratuvari
-
Kayseri, Tacchino, 38100
- Erciyes Universitesi Tip Fakultesi Radyoloji Laboratuvari
-
Kayseri, Tacchino, 38100
- Erciyes Universitesi Tip Fakultesi
-
Malatya, Tacchino, 44280
- Inonu Universitesi Tip Fakultesi Turgut Ozal Tip Merkezi
-
Manisa, Tacchino, 45000
- Celal Bayar University Medical Faculty
-
Samsun, Tacchino, 55139
- Ondokuz Mayis Universitesi Tip Fakultesi
-
-
-
-
-
Bangkok, Tailandia, 10400
- National Cancer Institute
-
Bangkok, Tailandia, 10400
- Cardiology Unit,Department of Medicine, Faculty of Medicine, Ramathibodi Hospital,
-
Bangkok, Tailandia, 10400
- Department of Radiology, Ramathibodi Hospital
-
-
-
-
-
Chernivtsi, Ucraina, 58013
- "Municipal Institution ""Chernivtsi Regional Clinical Oncology Center"",
-
Dnipropetrovsk, Ucraina, 49102
- MI 'City Dnipropetrovsk Multi-field Clin. Hospital #4 of DRC',
-
Kharkiv, Ucraina, 61070
- Municipal Non-Profit Enterprise "Regional Oncology Centre"
-
Kyiv, Ucraina, 03022
- National Cancer Institute
-
Uzhhorod, Ucraina, 88017
- "Central City Clinical Hospital, City Oncology Center, SHEI ""Uzhhorod National University"", Chair
-
Vinnytsia, Ucraina, 21029
- Podilskyy Regional Oncology Center, Chemotherapy Department
-
Zaporizhzhia, Ucraina, 69040
- Municipal Establishment 'Zaporizhzhia Regional Clinical Oncology Dispensary'
-
Zaporizhzhia, Ucraina, 69076
- LLC "Diaservis"
-
-
KYIV Region
-
Obukhiv, KYIV Region, Ucraina, 08720
- "MedX-Ray International Group" LLC
-
Obukhiv District, KYIV Region, Ucraina, 08720
- "Mediks-rey International Group" LLC
-
Obukhiv District, KYIV Region, Ucraina, 08720
- "MedX-rey International Group" LLC
-
-
Criteri di partecipazione
I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.
Criteri di ammissibilità
Età idonea allo studio
18 anni e precedenti (Adulto, Adulto più anziano)
Accetta volontari sani
No
Sessi ammissibili allo studio
Tutto
Descrizione
Inclusion Criteria:
- Confirmed diagnosis of low tumor burden, CD20-positive follicular lymphoma
- Ann Arbor Stage II, III, or IV
Exclusion Criteria:
- Not a candidate for treatment with rituximab as a single-agent
- Evidence of transformation to a high grade or diffuse large B-cell lymphoma
- Any previous systemic therapy for B-cell NHL, including chemotherapy, immunotherapy, or steroids
- Any prior treatment with rituximab
- Active, uncontrolled infection
Piano di studio
Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.
Come è strutturato lo studio?
Dettagli di progettazione
- Scopo principale: Trattamento
- Assegnazione: Randomizzato
- Modello interventistico: Assegnazione parallela
- Mascheramento: Doppio
Armi e interventi
Gruppo di partecipanti / Arm |
Intervento / Trattamento |
|---|---|
|
Sperimentale: PF-05280586
|
PF-05280586 (rituximab-Pfizer) concentrate for solution for infusion 375mg/m2 administered via IV infusion on Days 1, 8, 15, and 22
|
|
Comparatore attivo: MabThera®
|
MabThera® (rituximab-EU) concentrate for solution for infusion 375mg/m2 administered via IV infusion on Days 1, 8, 15, and 22
|
Cosa sta misurando lo studio?
Misure di risultato primarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
|
Overall Response Rate (ORR): Percentage of Participants With Overall Response (OR) at Week 26
Lasso di tempo: Week 26
|
ORR was defined as the percentage of participants who achieved complete response (CR) or partial response (PR) in accordance with the revised response criteria for malignant lymphoma (Cheson 2007).
CR was defined as disappearance of all evidence of disease.
PR was defined as regression of measureable disease and no new sites.
|
Week 26
|
Misure di risultato secondarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
|
Number of Participants With Treatment-Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs)
Lasso di tempo: Baseline up to Week 52
|
An AE was any untoward medical occurrence in participants who received study drug without regard to possibility of causal relationship.
SAE was an AE resulting in any of the following outcomes or deemed significant for any other reason: death; initial or prolonged inpatient hospitalization; life-threatening experience (immediate risk of dying); persistent or significant disability/incapacity; congenital anomaly.
Treatment-emergent were events after first dose of study drug that were absent before treatment or that worsened relative to pretreatment state.
AEs included both serious and non-serious.
|
Baseline up to Week 52
|
|
Number of Participants With Treatment Related Treatment-Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs)
Lasso di tempo: Baseline up to Week 52
|
Treatment-related AE was any untoward medical occurrence attributed to study drug in a participant who received study drug.
SAE was an AE resulting in any of the following outcomes or deemed significant for any other reason: death; initial or prolonged inpatient hospitalization; life-threatening experience (immediate risk of dying); persistent or significant disability/incapacity; congenital anomaly.
Treatment-emergent were events after first dose of study drug that were absent before treatment or that worsened relative to pretreatment state.
Relatedness to treatment was assessed by investigator.
AEs included both serious and non-serious AEs.
|
Baseline up to Week 52
|
|
Number of Participants With Grade 3 or Higher Treatment-Emergent Adverse Events (AEs) as Graded by National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version 4.03
Lasso di tempo: Baseline up to Week 52
|
An AE was any untoward medical occurrence in participant who received study drug without regard to possibility of causal relationship.
Grade 1=Mild, asymptomatic or mild symptoms, Grade 2=Moderate; minimal, local or noninvasive intervention indicated, Grade 3 (Severe) events=unacceptable or intolerable events, significantly interrupting usual daily activity, require systemic drug therapy/other treatment.
Grade 4 (Life threatening) events caused participant to be in imminent danger of death.
Grade 5 = death.
Treatment-emergent were events after first dose of study drug that were absent before treatment or that worsened relative to pretreatment state.
|
Baseline up to Week 52
|
|
Number of Participants With Grade 3 or Higher Treatment-Related Treatment-Emergent Adverse Events (AEs) as Graded by National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version 4.03
Lasso di tempo: Baseline up to Week 52
|
Treatment-related AE was any untoward medical occurrence attributed to study drug in a participant who received study drug.
Grade 1=Mild, asymptomatic or mild symptoms, Grade 2=Moderate; minimal, local or noninvasive intervention indicated; Grade 3 (Severe) events=unacceptable or intolerable events, significantly interrupting usual daily activity, require systemic drug therapy/other treatment.
Grade 4 (Life-threatening) events caused participant to be in imminent danger of death.
Grade 5 = death.
Treatment-emergent were events after first dose of study drug that were absent before treatment or that worsened relative to pretreatment state.
|
Baseline up to Week 52
|
|
Number of Participants With Clinically Significant Laboratory Abnormalities
Lasso di tempo: Baseline up to Week 52
|
Criteria for clinically significant laboratory abnormalities included total bilirubin (TB) less than (<) 2*upper limit of normal (ULN), alanine aminotransferase (ALT)<3*ULN; TB<2*ULN, ALT more than (>) 3 equal to (=) *ULN; TB<2*ULN, aspartate aminotransferase (AST)<3*ULN; TB<2*ULN, AST>=3*ULN.
Data for only those categories are reported for which at least one participant had clinically significant laboratory abnormality.
|
Baseline up to Week 52
|
|
Time to Treatment Failure (TTF)
Lasso di tempo: From randomization until disease progression, death or permanent discontinuation from treatment/study due to any reason, or up to Week 52
|
TTF was defined as the time (in months) from date of randomization to first progression of disease based on central review, death due to any cause, or permanent discontinuation from treatment, or discontinuation from study for any reason, whichever came first.
Progression was defined as any new lesion or increase by greater than or equal to (>=) 50% of previously involved sites from nadir.
TTF was calculated using Kaplan-Meier method.
|
From randomization until disease progression, death or permanent discontinuation from treatment/study due to any reason, or up to Week 52
|
|
Progression-Free Survival (PFS)
Lasso di tempo: From randomization until disease progression or death due to any cause or up to Week 52
|
PFS was defined as the time (in months) from date of randomization to first progression of disease (PD) based on central review or death due to any cause in the absence of documented PD.
PD was defined as any new lesion or increase by >=50% of previously involved sites from nadir.
PFS was calculated using Kaplan-Meier method.
|
From randomization until disease progression or death due to any cause or up to Week 52
|
|
Percentage of Participants With Complete Remission (CR) at Week 26
Lasso di tempo: Week 26
|
Complete Remission (CR) was defined as disappearance of all evidence of disease.
CR was assessed by central review based on scans done at Week 26.
|
Week 26
|
|
Duration of Response (DOR)
Lasso di tempo: From date of first documentation of overall response to first documentation of PD or to death due to any cause in absence of PD or up to Week 52
|
DOR was defined as the time (in months) from date of the first documentation of overall response (CR or PR) to the first documentation of progressive disease (PD) based on central review or to death due to any cause in the absence of documented PD.
CR was defined as disappearance of all evidence of disease.
PR was defined as regression of measureable disease and no new sites.
PD was defined as any new lesion or increase by >=50% of previously involved sites from nadir.
DOR was calculated using Kaplan-Meier method.
|
From date of first documentation of overall response to first documentation of PD or to death due to any cause in absence of PD or up to Week 52
|
|
Overall Survival
Lasso di tempo: From randomization until death due to any cause or up to Week 52
|
Overall survival was defined as the time (in months) from date of randomization to death due to any cause.
For participants who were alive, overall survival was censored at the last contact.
Overall survival was calculated using Kaplan-Meier method.
|
From randomization until death due to any cause or up to Week 52
|
|
Maximum Observed Serum Concentration (Cmax) of PF-05280586 and Rituximab-EU
Lasso di tempo: Predose (within 4 hours prior to start of infusion) on Days 1, 8, 15 and 22; within 15 minutes prior to end of infusion on Days 1 and 22
|
Predose (within 4 hours prior to start of infusion) on Days 1, 8, 15 and 22; within 15 minutes prior to end of infusion on Days 1 and 22
|
|
|
Minimum Observed (Trough) Serum Concentration (Ctrough) of PF-05280586 and Rituximab-EU
Lasso di tempo: Predose (within 4 hours prior to the start of dosing) on Day 1, 8, 15, and 22
|
Predose (within 4 hours prior to the start of dosing) on Day 1, 8, 15, and 22
|
|
|
Cluster of Differentiation (CD) 19-Positive B-Cell Counts
Lasso di tempo: Baseline, Week 2, 3, 4, 5, 13, 26, 39, 52
|
Baseline, Week 2, 3, 4, 5, 13, 26, 39, 52
|
|
|
Number of Participants With Positive Anti-Drug Antibodies (ADAs) and Neutralizing Antibodies (NAbs)
Lasso di tempo: Baseline up to Week 52
|
Human serum ADA samples were analyzed for the presence or absence of anti-rituximab antibodies or anti-PF-05280586 antibodies using the validated drug-specific assay with a tiered approach using screening, confirmation and titer/quantitation.
Human NAb serum samples testing ADA positive were analyzed for the presence or absence of neutralizing anti-rituximab antibody and neutralizing anti-PF-05280586 antibody using the validated drug-specific assay with a tiered approach using screening, confirmation and titer/quantitation.
Participants with their ADA titer >= 1.88 were considered to be ADA positive.
Only participants with a positive ADA result were further tested for NAb.
|
Baseline up to Week 52
|
|
Number of Participants Reporting Immune-Based Adverse Effects
Lasso di tempo: Baseline up to Week 52
|
Immune-based adverse effects included infusion related reaction (IRR), adverse events which fulfill Sampson's criteria, and adverse events which belong to the Standardized Medical Dictionary for Regulatory Activities (MedDRA) Queries (SMQs) anaphylaxis or hypersensitivity reactions.
Potential allergic and anaphylactic reactions were identified programmatically based on the criteria of Sampson et al, (2006).
|
Baseline up to Week 52
|
Collaboratori e investigatori
Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.
Sponsor
Pubblicazioni e link utili
La persona responsabile dell'inserimento delle informazioni sullo studio fornisce volontariamente queste pubblicazioni. Questi possono riguardare qualsiasi cosa relativa allo studio.
Pubblicazioni generali
- Courville J, Nastoupil L, Kaila N, Kelton J, Zhang J, Alcasid A, Nava-Parada P. Factors Influencing Infusion-Related Reactions Following Dosing of Reference Rituximab and PF-05280586, a Rituximab Biosimilar. BioDrugs. 2021 Jul;35(4):459-468. doi: 10.1007/s40259-021-00487-6. Epub 2021 Jun 21.
- Sharman JP, Liberati AM, Ishizawa K, Khan T, Robbins J, Alcasid A, Rosenberg JA, Aurer I. A Randomized, Double-Blind, Efficacy and Safety Study of PF-05280586 (a Rituximab Biosimilar) Compared with Rituximab Reference Product (MabThera(R)) in Subjects with Previously Untreated CD20-Positive, Low-Tumor-Burden Follicular Lymphoma (LTB-FL). BioDrugs. 2020 Apr;34(2):171-181. doi: 10.1007/s40259-019-00398-7.
Collegamenti utili
Studiare le date dei record
Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.
Studia le date principali
Inizio studio (Effettivo)
30 settembre 2014
Completamento primario (Effettivo)
23 ottobre 2017
Completamento dello studio (Effettivo)
19 aprile 2018
Date di iscrizione allo studio
Primo inviato
7 agosto 2014
Primo inviato che soddisfa i criteri di controllo qualità
7 agosto 2014
Primo Inserito (Stima)
11 agosto 2014
Aggiornamenti dei record di studio
Ultimo aggiornamento pubblicato (Effettivo)
20 giugno 2019
Ultimo aggiornamento inviato che soddisfa i criteri QC
18 giugno 2019
Ultimo verificato
1 giugno 2019
Maggiori informazioni
Termini relativi a questo studio
Parole chiave
Termini MeSH pertinenti aggiuntivi
- Malattie del sistema immunitario
- Neoplasie per tipo istologico
- Neoplasie
- Malattie linfoproliferative
- Malattie linfatiche
- Disturbi immunoproliferativi
- Linfoma non Hodgkin
- Linfoma
- Linfoma, follicolare
- Effetti fisiologici delle droghe
- Agenti antireumatici
- Agenti antineoplastici
- Fattori immunologici
- Agenti antineoplastici, immunologici
- Rituximab
Altri numeri di identificazione dello studio
- B3281006
- 2014-000132-41 (Numero EudraCT)
- REFLECTIONS (Altro identificatore: Alias Study Number)
Piano per i dati dei singoli partecipanti (IPD)
Hai intenzione di condividere i dati dei singoli partecipanti (IPD)?
Sì
Descrizione del piano IPD
Pfizer will provide access to individual de-identified participant data and related study documents (e.g.
protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions.
Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical_trials/trial_data_and_results/data_requests.
Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .