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Clinical Study to Evaluate the Safety, Tolerability and Pharmacokinetics (PKs) of ZYDPLA1 Following Oral Administration in Healthy Volunteers

1 dicembre 2015 aggiornato da: Zydus Lifesciences Limited

A Randomized, Double-blind, Placebo-controlled Phase I Clinical Study to Evaluate the Safety, Tolerability and Pharmacokinetics of ZYDPLA1, a Novel DPP- IV Inhibitor, Following Oral Administration in Healthy Volunteers

This First in Human (FIH) Phase I study intends to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of ZYDPLA1 in normal healthy adult volunteers.

Panoramica dello studio

Stato

Completato

Condizioni

Descrizione dettagliata

Glucose-dependent insulinotropic polypeptide (GIP) and Glucagon-like peptide (GLP-1) are incretin hormones, which stimulate glucose dependent insulin secretion, inhibit glucagon secretion, delay gastric emptying, suppress appetite and improve peripheral glucose uptake and disposal. Dipeptidyl peptidase-IV (DPP-IV) is a serine protease, which selectively cleaves the first two amino acids of GIP and GLP-1 thereby making it inactive. Inhibition of DPP-IV activity elevates endogenous GIP, GLP-1 and insulin levels thereby improving glucose excursion and exhibits antidiabetic activity. Since no orally active GLP-1 agonists are available, clinically orally bioavailable DPP-IV inhibitors hold great potential for the treatment of type 2 diabetes mellitus.

Cadila Healthcare Ltd. developed a novel and orally bioavailable DPP-IV inhibitor (ZYDPLA1). In-vitro studies confirm selective DPPIV inhibitory activity of the ZYDPLA1. Pre-clinical in vivo pharmacodynamic, absorption, distribution, metabolism and excretion (ADME) & toxicological studies showed the promising antidiabetic activity, good exposure and safety profile of ZYDPLA1(in various animal models).

Hence a randomized, double-blind, placebo-controlled first in man trial proposed to evaluate the safety and tolerability of ZYDPLA1 in healthy volunteers.

This study included 4 plans:

i) single dose escalation study ii) multiple dose escalation study, iii) gender effect study and iv) food effect study.

Tipo di studio

Interventistico

Iscrizione (Effettivo)

84

Fase

  • Fase 1

Contatti e Sedi

Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.

Luoghi di studio

    • California
      • Chula Vista, California, Stati Uniti, 91911
        • Profil Institute for Clinical Research

Criteri di partecipazione

I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.

Criteri di ammissibilità

Età idonea allo studio

Da 18 anni a 65 anni (Adulto, Adulto più anziano)

Accetta volontari sani

Sessi ammissibili allo studio

Tutto

Descrizione

Inclusion Criteria:

  1. Healthy male or female between 18 and 65 years of age.
  2. Male subjects must agree to use one of the contraception methods during the study. Male contraceptive options include: Vasectomy, Abstinence requiring the use of contraceptives if becoming sexually active, or double barrier method (condom with spermicide, diaphragm or cervical cap). No Sperm donation for at least up to 90 days after last investigational product.
  3. BMI within the range 18.0 - 30.0 kg/m2 BMI value should be rounded off to one significant digit after decimal point. BMI values should be rounded to the nearest integer (ex. 30.4 rounds down to 30, while 17.5 rounds up to 18).
  4. Capable of giving written informed consent, which includes compliance with protocol.
  5. Corrected QT interval (QTc) interval < 450msec (as measured by QTcF)
  6. For gender effect study, only females with history of sterility or at least 1 year menopause or use of long acting non hormonal contraceptive measures (e.g., intrauterine device) will be recruited. Surgical sterility is defined as either bilateral tubal ligation/occlusion, bilateral oophorectomy or hysterectomy.
  7. Negative Urine drug screen including amphetamine, barbiturates, benzodiazepines, cannabinoid, cocaine, opiates, methadone and phencyclidine within 28 days prior to initiation of the study and prior to check-in.

Exclusion Criteria:

  1. Presence or history of pancreatitis at any time {Serum Amylase/Serum Lipase more than significant upper normal limit (≥1.5 times UNL)}
  2. Presence or history of severe gastrointestinal disease in the last 6 months
  3. Presence or history of renal insufficiency at any time {Serum creatinine more than upper normal limit (UNL)}
  4. Active liver disease and/or liver transaminases greater than 1.5 times UNL
  5. History or presence of other systemic disorders or diseases (e.g., respiratory, gastrointestinal, endocrine, immunological, dermatological, neurological, psychiatric disease or any other body system involvement)
  6. History or presence of any medication in the last 14 days
  7. History or presence of significant alcoholism or drug abuse within the past 1 year
  8. History or presence of significant smoking (more than 10 cigarettes per day) or consumption of tobacco products (more than 10 times per day)
  9. Difficulty with donating blood or difficulty in accessibility of veins.
  10. Intolerance to venipuncture.
  11. Systolic blood pressure more than 150 mmHg and less than 100 mmHg and diastolic blood pressure more than 90 mmHg
  12. Pulse rate less than 50/minute and more than 100/minute
  13. Any clinically significant laboratory findings during screening
  14. History or presence of any clinically significant electrocardiogram (ECG) abnormalities during screening as determined by the Principal Investigator.
  15. Major illness and/or major surgery in last 3 months
  16. Volunteers who have participated in any drug research study other than the present trial within the past 30 days (Subjected to Insurance that subject has not participated in long acting drug including new biological entities/new chemical entities/biosimilar products).
  17. Volunteers who have donated one unit (450 mL) of blood in the past 3 months
  18. Positive Alcohol breath analyzer at the time of Screening and Check-in
  19. A positive hepatitis screen (includes subtype B and C) and/or a positive test result for HIV antibody.
  20. Any food allergy, intolerance, restriction or special diet that, in the opinion of the Principal investigator or Sub-investigator, could contraindicate the study participant's participation in this study.
  21. For gender effect study, female volunteers with following criteria will not be recruited:

    • History of pregnancy or lactation in the past 3 months
    • Fertile female volunteers not protected against pregnancy by adequate long-term anti-fertility measures
    • History of less than 1 year of menopause and not using adequate long-term antifertility measures
    • Using hormonal contraceptives
    • Using hormone replacement therapy
    • Unable to give assurance for protection against pregnancy for 3 months after the participation in this trial
    • Positive urine pregnancy test on the day of check-in (women of child bearing potential)
    • Positive serum β-human chorionic gonadotropin (hCG) level at the screening visit (women of child bearing potential)

Piano di studio

Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.

Come è strutturato lo studio?

Dettagli di progettazione

  • Assegnazione: Randomizzato
  • Modello interventistico: Assegnazione parallela
  • Mascheramento: Quadruplicare

Armi e interventi

Gruppo di partecipanti / Arm
Intervento / Trattamento
Comparatore attivo: ZYDPLA1 tablet
ZYDPLA1 tablets: Route of administration: Oral Dosage (Single Ascending Study): 1 mg, 5mg, 20mg, 50mg, 100mg, 200mg Multiple Ascending Study: 100mg, 200mg Food effect and Gender effect study: 200mg
The oral dose of ZYDPLA1 tablet administered with 240 ± 10 mL of water at ambient temperature.
Comparatore placebo: Placebo
Placebo tablets: Route of administration: Oral Dosage (Single Ascending Study): 1 mg, 5mg, 20mg, 50mg, 100mg, 200mg Multiple Ascending Study: 100mg, 200mg Food effect and Gender effect study: 200mg
The oral dose of placebo tablet administered with 240 ± 10 mL of water at ambient temperature.

Cosa sta misurando lo studio?

Misure di risultato primarie

Misura del risultato
Lasso di tempo
Safety and tolerability assessed by monitoring adverse events, clinical, laboratory, electrocardiogram, and vital signs examinations.
Lasso di tempo: 14 Days (Plan 1, III, and IV);
14 Days (Plan 1, III, and IV);
Safety and tolerability assessed by monitoring adverse events, clinical, laboratory, electrocardiogram, and vital signs examinations.
Lasso di tempo: 28 Days (Plan II)
28 Days (Plan II)

Misure di risultato secondarie

Misura del risultato
Lasso di tempo
Pharmacokinetic assessment: Maximum plasma concentration (Cmax)
Lasso di tempo: 14 Days (Plan I, III, and IV)
14 Days (Plan I, III, and IV)
Maximum plasma concentration (Cmax)
Lasso di tempo: 28 Days (Plan II)
28 Days (Plan II)
Time to reach maximum plasma concentration (Tmax)
Lasso di tempo: 14 Days (Plan I, III, and IV)
14 Days (Plan I, III, and IV)
Time to reach maximum plasma concentration (Tmax)
Lasso di tempo: 28 Days (Plan II)
28 Days (Plan II)
Area under the curve from the time of dosing to the last measurable concentration (AUC0-t)
Lasso di tempo: 14 Days (Plan I, III, and IV)
14 Days (Plan I, III, and IV)
Area under the curve from the time of dosing to the last measurable concentration (AUC0-t)
Lasso di tempo: 28 Days (Plan II)
28 Days (Plan II)
Area under the curve from the time of dosing to the infinity (AUC 0-inf)
Lasso di tempo: 14 Days (Plan I, III, and IV)
14 Days (Plan I, III, and IV)
Area under the curve from the time of dosing to the infinity (AUC 0-inf)
Lasso di tempo: 28 Days (Plan II)
28 Days (Plan II)
Terminal half life (t1/2)
Lasso di tempo: 14 Days (Plan I, III, and IV)
14 Days (Plan I, III, and IV)
Terminal half life (t1/2)
Lasso di tempo: 28 Days (Plan II)
28 Days (Plan II)
Elimination rate constant (λz)
Lasso di tempo: 14 Days (Plan I, III, and IV)
14 Days (Plan I, III, and IV)
Elimination rate constant (λz)
Lasso di tempo: 28 Days (Plan II)
28 Days (Plan II)
Clearance (CL)
Lasso di tempo: 14 Days (Plan I, III, and IV)
14 Days (Plan I, III, and IV)
Clearance (CL)
Lasso di tempo: 28 Days (Plan II)
28 Days (Plan II)
Volume of distribution (Vd)
Lasso di tempo: 14 Days (Plan I, III, and IV)
14 Days (Plan I, III, and IV)
Volume of distribution (Vd)
Lasso di tempo: 28 Days (Plan II)
28 Days (Plan II)
Accumulation index
Lasso di tempo: 28 Days (Plan II)
28 Days (Plan II)
Pharmacodynamic effect (Plan I, III, and IV) assessment by monitoring primary parameters: Plasma DPPIV
Lasso di tempo: 14 Days
14 Days
Pharmacodynamic effect (Plan II) assessment by monitoring primary parameters: Plasma DPPIV
Lasso di tempo: 28 Days
28 Days
Glucagon-like peptide-1 (active and total)
Lasso di tempo: 14 Days
14 Days
Glucagon-like peptide-1 (active and total)
Lasso di tempo: 28 Days
28 Days
Secondary parameters: Plasma glucose
Lasso di tempo: 14 Days
14 Days
Plasma glucose
Lasso di tempo: 28 Days
28 Days
Serum insulin
Lasso di tempo: 14 Days
14 Days
Serum insulin
Lasso di tempo: 28 Days
28 Days
C-peptide
Lasso di tempo: 14 Days
14 Days
C-peptide
Lasso di tempo: 28 Days
28 Days
Glucagon
Lasso di tempo: 14 Days
14 Days
Glucagon
Lasso di tempo: 28 Days
28 Days

Collaboratori e investigatori

Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.

Investigatori

  • Direttore dello studio: Rajendrakumar H Jani, Ph.D.,, Zydus Lifesciences Limited

Studiare le date dei record

Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.

Studia le date principali

Inizio studio

1 ottobre 2014

Completamento primario (Effettivo)

1 ottobre 2015

Completamento dello studio (Effettivo)

1 ottobre 2015

Date di iscrizione allo studio

Primo inviato

24 novembre 2015

Primo inviato che soddisfa i criteri di controllo qualità

1 dicembre 2015

Primo Inserito (Stima)

3 dicembre 2015

Aggiornamenti dei record di studio

Ultimo aggiornamento pubblicato (Stima)

3 dicembre 2015

Ultimo aggiornamento inviato che soddisfa i criteri QC

1 dicembre 2015

Ultimo verificato

1 novembre 2015

Maggiori informazioni

Termini relativi a questo studio

Altri numeri di identificazione dello studio

  • ZYDPLA1 1001

Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .

Prove cliniche su ZYDPLA1 tablet

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