- ICH GCP
- Registro degli studi clinici negli Stati Uniti
- Sperimentazione clinica NCT07782255
Interdisciplinary Therapeutic Intervention for People With Persistent Pain
Study Objective The project aims to implement an interdisciplinary therapeutic program for people suffering from persistent pain (specifically fibromyalgia) to optimize their quality of life through a comprehensive approach that addresses physical, psychological, social, and nutritional dimensions.
What does the intervention consist of?
The initiative is a social innovation proposal structured around four fundamental pillars, carried out by a team of physical therapists (kinesiologists), nutritionists, and psychologists:
Adapted physical activity: Low-to-moderate intensity in-person sessions to improve cardiovascular capacity, reduce pain sensitivity, and promote general well-being.
Therapeutic education: Talks (online/in-person) to improve understanding of the condition and foster self-care.
Nutritional counseling: Assessment of nutritional status and guidance on anti-inflammatory nutrition, healthy habits, and key micronutrients.
Mental health workshops: Strategies such as cognitive-behavioral therapy, mindfulness, and stress management to improve emotional regulation and resilience.
Methodology and Participation Population: The study is aimed at individuals over 18 years old diagnosed with fibromyalgia who are members of the Fibromyalgia Corporation of the Valparaíso Region.
Procedure: It includes an initial assessment (pre-test), the implementation of the interdisciplinary program, and a final assessment (post-test) to measure functional, nutritional, and psychosocial changes.
Safety: The procedures are non-invasive. To minimize any physical or emotional discomfort, the team will implement a gradual progression in exercises and provide emotional support spaces in a safe and supportive environment.
Expected Benefits For participants: A significant improvement in their functional and nutritional status and psychosocial well-being is expected, positively impacting their quality of life and perceived pain levels.
For the community: The project seeks to make the needs of people with fibromyalgia visible, strengthen the local health network, and foster a more resilient and supportive community.
For professional training: By working under a service-learning model, Physical Therapy and Nutrition students will acquire practical skills by working in real contexts alongside professionals.
Ethical Commitments Confidentiality: All information will be treated with strict confidentiality protocols, using alphanumeric codes to anonymize user data.
Voluntariness: Participation is entirely voluntary. Interested individuals will receive clear information, will be able to resolve any doubts, and must sign an informed consent form before beginning.
Transparency: The study does not involve monetary incentives and has no conflicts of interest with external institutions.
This project is led by the principal investigator Marco Antonio Higueras Contreras, in collaboration with co-investigator Natalia María Muñoz Palma, both from the Department of Rehabilitation, Intervention, and Therapeutic Approach at the University of Playa Ancha.
Panoramica dello studio
Stato
Condizioni
Intervento / Trattamento
Descrizione dettagliata
Introduction and Social Justification The project "Interdisciplinary Therapeutic Intervention for People with Persistent Pain" emerges as an innovative response to the complex problem of chronic pain, a condition that transcends physical limitation to deeply affect people's psychological, social, and economic well-being. This proposal is framed within a social innovation model, integrating professional knowledge with community expertise to offer a comprehensive, person-centered approach.
Project Objectives The general objective of this research is to implement an interdisciplinary therapeutic intervention that addresses the physical, psychological, social, and nutritional dimensions of people with persistent pain to optimize their quality of life. To achieve this, specific objectives have been established, including the design and execution of a therapeutic plan that combines physical activity, health education, nutritional counseling, and psychological support. Furthermore, the project seeks to promote self-management of the persistent pain condition, evaluate the functional, nutritional, and psychosocial impact associated with pain, and strengthen local health networks through the linkage between territorial actors, community organizations, and academia.
Intervention Components The intervention is structured around four key components. First, aerobic physical activity is included, which consists of low-to-moderate intensity therapeutic exercises that are progressive and adapted; these will be performed by physical therapists (kinesiologists) and include between 12 and 16 sessions distributed over two months. Second, therapeutic education will be provided through talks on the pathophysiology of pain, coping strategies, and healthy habits, all executed in an online format. Third, the nutritional approach will include an assessment of nutritional status, considering weight and body composition, as well as personalized counseling on anti-inflammatory nutrition, hydration, and key micronutrients. Finally, the mental health component will integrate the use of cognitive-behavioral therapy, mindfulness, and stress management techniques to strengthen the participants' resilience and emotional regulation.
Methodology and Study Design The study is defined as descriptive-associative with a quantitative, longitudinal approach. The research focuses on members of the Fibromyalgia Corporation of the Valparaíso Region, with a non-probabilistic convenience sample composed of 20 people.
Among the evaluations performed, nutritional status is measured through the calculation of BMI, fat mass, and muscle mass, using an Omron HBF514 scale and a Seca 213 stadiometer, in addition to applying food frequency questionnaires. To evaluate functionality and physical capacity, instruments such as the Timed Up and Go (TUG) test, hand dynamometry, the 6-minute walk test, and the SF-36 quality of life questionnaire are applied. Finally, for psychosocial perception, various validated scales are used, such as the VAS (Visual Analog Scale), the McGill Pain Questionnaire, the Hospital Anxiety and Depression Scale, and the Tampa Scale for Kinesiophobia.
Safety, Ethics, and Confidentiality The project guarantees professional and ethical treatment at all times. In the event of any potential physical or emotional discomfort that may arise, effective mitigation measures have been planned, such as the gradual progression of physical activities and the provision of emotional containment spaces during psychological interventions. All data collected from participants will be anonymized through the assignment of alphanumeric codes and will be guarded under strict confidentiality protocols for a period of three years. Participation in this study is entirely voluntary and will be formalized through an informed consent process that is clear and understandable to all involved.
Research Team The project is led by physical therapist (kinesiologist) Marco Antonio Higueras Contreras, Master in Orthopedic Manual Therapy, together with nutritionist Natalia María Muñoz Palma, Master in Pedagogy and Nutrition. Both are professors at the University of Playa Ancha and have extensive academic and professional experience in the areas of rehabilitation, diet therapy, and the management of chronic conditions.
Tipo di studio
Iscrizione (Effettivo)
Fase
- Non applicabile
Contatti e Sedi
Luoghi di studio
-
-
Valparaiso
-
Valparaíso, Valparaiso, Chile, 2340000
- University Playa Ancha
-
-
Criteri di partecipazione
Criteri di ammissibilità
Età idonea allo studio
- Adulto
- Adulto più anziano
Accetta volontari sani
Descrizione
Inclusion Criteria:
- Diagnosis: Individuals with a medical diagnosis of fibromyalgia.
- Membership: Members of the Fibromyalgia Corporation of the Valparaíso Region.
- Age: Adults aged 18 years or older.
- Voluntary Participation: Individuals who provide informed consent to participate in the study.
Exclusion Criteria:
- Severe Comorbidities: Individuals with severe uncontrolled medical or psychiatric conditions that prevent physical activity or participation in the intervention.
- Inability to Follow Instructions: Individuals unable to follow the online or in-person instructions provided during the therapeutic sessions.
- Recent Surgery or Acute Injury: Individuals with acute physical injuries or recent surgeries that contraindicate exercise.
- Pregnancy: Women who are currently pregnant.
Piano di studio
Come è strutturato lo studio?
Dettagli di progettazione
- Scopo principale: Trattamento
- Assegnazione: N / A
- Modello interventistico: Assegnazione di gruppo singolo
- Mascheramento: Nessuno (etichetta aperta)
Armi e interventi
Gruppo di partecipanti / Arm |
Intervento / Trattamento |
|---|---|
|
Sperimentale: Multimodal Interdisciplinary Intervention
Participants in this study group receive an interdisciplinary intervention consisting of: 1) adapted aerobic physical activity (two sessions per week for two months); 2) online therapeutic education sessions regarding the pathophysiology of pain and coping strategies; 3) mental health counseling focused on cognitive-behavioral techniques, mindfulness, and stress management; and 4) personalized nutritional counseling including assessment and dietary guidance to manage symptoms.
|
Participants receive an interdisciplinary program over two months, consisting of: 1) Adapted aerobic physical activity: two weekly sessions focusing on low-to-moderate intensity exercises. 2) Therapeutic education: online sessions covering pain pathophysiology and self-management strategies. 3) Mental health counseling: interventions based on cognitive-behavioral techniques, mindfulness, and stress management. 4) Nutritional counseling: personalized assessment and dietary guidance focused on anti-inflammatory habits and symptom management. This intervention distinguishes itself from other studies through its unique social innovation model, which integrates professional healthcare with community-based agents. It utilizes a service-learning framework, where students provide care under expert supervision to foster mutual learning. Additionally, it targets a specific population-the Valparaíso Fibromyalgia Corporation-synchronizing four pillars for holistic patient empowerment. |
Cosa sta misurando lo studio?
Misure di risultato primarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
|
Health-related quality of life
Lasso di tempo: Baseline (before the start of the 2-month interdisciplinary program) and at 2 months post-intervention, immediately following the completion of the 12 to 16 therapeutic sessions.
|
The score is based on the 36-Item Short Form Health Survey version 2 (SF-36v2).
The scores are transformed to a scale ranging from a minimum value of 0 to a maximum value of 100.
Higher scores indicate a better outcome, representing a better state of health and quality of life.
|
Baseline (before the start of the 2-month interdisciplinary program) and at 2 months post-intervention, immediately following the completion of the 12 to 16 therapeutic sessions.
|
Misure di risultato secondarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
|
Functional mobility
Lasso di tempo: Baseline (before the start of the 2-month interdisciplinary program) and at 2 months post-intervention, immediately following the completion of the 12 to 16 therapeutic sessions.
|
Functional mobility was assessed using the Timed Up and Go (TUG) test, which is measured in seconds.
The theoretical minimum value is 0 seconds, and there is no defined maximum value.
Higher scores (greater time taken to complete the test) mean a worse outcome.
|
Baseline (before the start of the 2-month interdisciplinary program) and at 2 months post-intervention, immediately following the completion of the 12 to 16 therapeutic sessions.
|
|
Lower body strength and functional capacity
Lasso di tempo: Baseline (before the start of the 2-month interdisciplinary program) and at 2 months post-intervention, immediately following the completion of the 12 to 16 therapeutic sessions.
|
Lower body strength and functional capacity were assessed using the 30-Second Chair Stand Test (30-CST).
The score represents the number of full stands completed within 30 seconds.
The theoretical minimum value is 0, and there is no defined maximum value.
Higher scores mean a better outcome.
|
Baseline (before the start of the 2-month interdisciplinary program) and at 2 months post-intervention, immediately following the completion of the 12 to 16 therapeutic sessions.
|
|
Upper limb muscle strength
Lasso di tempo: Baseline (before the start of the 2-month interdisciplinary program) and at 2 months post-intervention, immediately following the completion of the 12 to 16 therapeutic sessions.
|
Upper limb muscle strength was assessed using the Handgrip Strength Test, typically measured in kilograms (kg) using a hand-held Jamar's dynamometer.
The theoretical minimum value is 0 kg, and there is no defined maximum value.
Higher scores mean a better outcome.
|
Baseline (before the start of the 2-month interdisciplinary program) and at 2 months post-intervention, immediately following the completion of the 12 to 16 therapeutic sessions.
|
|
Functional exercise capacity
Lasso di tempo: Baseline (before the start of the 2-month interdisciplinary program) and at 2 months post-intervention, immediately following the completion of the 12 to 16 therapeutic sessions.
|
Functional exercise capacity were assessed using the 6-Minute Walk Test (6MWT), with the total distance measured in meters.
The theoretical minimum value is 0 meters, and there is no defined maximum value.
Higher scores (greater distance walked) mean a better outcome.
|
Baseline (before the start of the 2-month interdisciplinary program) and at 2 months post-intervention, immediately following the completion of the 12 to 16 therapeutic sessions.
|
|
Self-efficacy
Lasso di tempo: Baseline (before the start of the 2-month interdisciplinary program) and at 2 months post-intervention, immediately following the completion of the 12 to 16 therapeutic sessions.
|
Self-efficacy was assessed using the General Self-Efficacy Scale by Baessler and Schwarzer.
The scale consists of 10 items, each scored from 1 to 4. Total scores range from a minimum value of 10 to a maximum value of 40.
Higher scores mean a better outcome, representing a higher level of perceived self-efficacy.
|
Baseline (before the start of the 2-month interdisciplinary program) and at 2 months post-intervention, immediately following the completion of the 12 to 16 therapeutic sessions.
|
|
Anxiety and depression
Lasso di tempo: Baseline (before the start of the 2-month interdisciplinary program) and at 2 months post-intervention, immediately following the completion of the 12 to 16 therapeutic sessions.
|
Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS).
The scale consists of 14 items divided into two 7-item subscales: Anxiety (HADS-A) and Depression (HADS-D).
Each item is scored from 0 to 3. The score for each subscale ranges from a minimum value of 0 to a maximum value of 21, yielding a total score range of 0 to 42.
Higher scores mean a worse outcome, indicating greater levels of anxiety and/or depression.
|
Baseline (before the start of the 2-month interdisciplinary program) and at 2 months post-intervention, immediately following the completion of the 12 to 16 therapeutic sessions.
|
|
Pain characteristics and intensity
Lasso di tempo: Baseline (before the start of the 2-month interdisciplinary program) and at 2 months post-intervention, immediately following the completion of the 12 to 16 therapeutic sessions.
|
Pain characteristics and intensity were assessed using the McGill Pain Questionnaire (MPQ).
The MPQ provides multiple scoring components, most commonly the Total Pain Rating Index (PRI, derived from pain descriptors with scores typically ranging from 0 to 78), Present Pain Intensity (PPI, categorical scale ranging from 0 to 5), and a Visual Analogue Scale (VAS, typically ranging from 0 to 100).
For all measurement components, the theoretical minimum value is 0. Higher scores mean a worse outcome, indicating greater pain severity and complexity.
|
Baseline (before the start of the 2-month interdisciplinary program) and at 2 months post-intervention, immediately following the completion of the 12 to 16 therapeutic sessions.
|
|
Pain-related catastrophic thinking
Lasso di tempo: Baseline (before the start of the 2-month interdisciplinary program) and at 2 months post-intervention, immediately following the completion of the 12 to 16 therapeutic sessions.
|
Pain-related catastrophic thinking was assessed using the Pain Catastrophizing Scale.
The questionnaire consists of 13 items, each rated on a 5-point scale (scored from 0 to 4).
Total scores range from a minimum value of 0 to a maximum value of 52.
Higher scores mean a worse outcome, indicating a higher degree of pain catastrophizing.
|
Baseline (before the start of the 2-month interdisciplinary program) and at 2 months post-intervention, immediately following the completion of the 12 to 16 therapeutic sessions.
|
|
Sleep quality
Lasso di tempo: Baseline (before the start of the 2-month interdisciplinary program) and at 2 months post-intervention, immediately following the completion of the 12 to 16 therapeutic sessions.
|
Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI).
The global score is calculated by summing 7 component scores.
The total score ranges from a minimum value of 0 to a maximum value of 21.
Higher scores mean a worse outcome, indicating poorer sleep quality and severe sleep difficulties.
|
Baseline (before the start of the 2-month interdisciplinary program) and at 2 months post-intervention, immediately following the completion of the 12 to 16 therapeutic sessions.
|
|
Kinesiophobia
Lasso di tempo: Baseline (before the start of the 2-month interdisciplinary program) and at 2 months post-intervention, immediately following the completion of the 12 to 16 therapeutic sessions.
|
Fear of movement or kinesiophobia was assessed using the 11-item Tampa Scale for Kinesiophobia (TSK-11SV).
The questionnaire consists of 11 items, each rated on a 4-point scale ranging from 1 to 4. Total scores range from a minimum value of 11 to a maximum value of 44.
Higher scores mean a worse outcome, indicating a greater fear of movement and re-injury.
|
Baseline (before the start of the 2-month interdisciplinary program) and at 2 months post-intervention, immediately following the completion of the 12 to 16 therapeutic sessions.
|
Collaboratori e investigatori
Sponsor
Investigatori
- Investigatore principale: Marco Higueras, Master and Bachelor, University Playa Ancha
Pubblicazioni e link utili
Pubblicazioni generali
- Geneen LJ, Moore RA, Clarke C, Martin D, Colvin LA, Smith BH. Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews. Cochrane Database Syst Rev. 2017 Apr 24;4(4):CD011279. doi: 10.1002/14651858.CD011279.pub3.
- Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Katz RS, Mease P, Russell AS, Russell IJ, Winfield JB, Yunus MB. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res (Hoboken). 2010 May;62(5):600-10. doi: 10.1002/acr.20140.
- Fitzcharles MA, Ste-Marie PA, Goldenberg DL, Pereira JX, Abbey S, Choiniere M, Ko G, Moulin DE, Panopalis P, Proulx J, Shir Y; National Fibromyalgia Guideline Advisory Panel. 2012 Canadian Guidelines for the diagnosis and management of fibromyalgia syndrome: executive summary. Pain Res Manag. 2013 May-Jun;18(3):119-26. doi: 10.1155/2013/918216.
- Macfarlane GJ, Kronisch C, Dean LE, Atzeni F, Hauser W, Fluss E, Choy E, Kosek E, Amris K, Branco J, Dincer F, Leino-Arjas P, Longley K, McCarthy GM, Makri S, Perrot S, Sarzi-Puttini P, Taylor A, Jones GT. EULAR revised recommendations for the management of fibromyalgia. Ann Rheum Dis. 2017 Feb;76(2):318-328. doi: 10.1136/annrheumdis-2016-209724. Epub 2016 Jul 4.
- Clauw DJ. Fibromyalgia: a clinical review. JAMA. 2014 Apr 16;311(15):1547-55. doi: 10.1001/jama.2014.3266.
- Hauser W, Ablin J, Fitzcharles MA, Littlejohn G, Luciano JV, Usui C, Walitt B. Fibromyalgia. Nat Rev Dis Primers. 2015 Aug 13;1:15022. doi: 10.1038/nrdp.2015.22.
- Queiroz LP. Worldwide epidemiology of fibromyalgia. Curr Pain Headache Rep. 2013 Aug;17(8):356. doi: 10.1007/s11916-013-0356-5.
- Busch AJ, Webber SC, Brachaniec M, Bidonde J, Bello-Haas VD, Danyliw AD, Overend TJ, Richards RS, Sawant A, Schachter CL. Exercise therapy for fibromyalgia. Curr Pain Headache Rep. 2011 Oct;15(5):358-67. doi: 10.1007/s11916-011-0214-2.
- Bidonde J, Busch AJ, Schachter CL, Overend TJ, Kim SY, Goes SM, Boden C, Foulds HJ. Aerobic exercise training for adults with fibromyalgia. Cochrane Database Syst Rev. 2017 Jun 21;6(6):CD012700. doi: 10.1002/14651858.CD012700.
- Galvez-Sanchez CM, Reyes Del Paso GA. Diagnostic Criteria for Fibromyalgia: Critical Review and Future Perspectives. J Clin Med. 2020 Apr 23;9(4):1219. doi: 10.3390/jcm9041219.
- Pagliai G, Giangrandi I, Dinu M, Sofi F, Colombini B. Nutritional Interventions in the Management of Fibromyalgia Syndrome. Nutrients. 2020 Aug 20;12(9):2525. doi: 10.3390/nu12092525.
- Jurado-Priego LN, Cueto-Urena C, Ramirez-Exposito MJ, Martinez-Martos JM. Fibromyalgia: A Review of the Pathophysiological Mechanisms and Multidisciplinary Treatment Strategies. Biomedicines. 2024 Jul 11;12(7):1543. doi: 10.3390/biomedicines12071543.
- Healey EL, Jinks C, Foster NE, Chew-Graham CA, Pincus T, Hartshorne L, Cooke K, Nicholls E, Proctor J, Lewis M, Dent S, Wathall S, Hay EM, McBeth J. The feasibility and acceptability of a physical activity intervention for older people with chronic musculoskeletal pain: The iPOPP pilot trial protocol. Musculoskeletal Care. 2018 Mar;16(1):118-132. doi: 10.1002/msc.1222. Epub 2017 Dec 8.
- Ranque S, Laurin J, Linguraru MG, Jiang Z, Loundou A, Boyer L, Guieu R, Boucraut J, Sault C, Simon J, Barthelemy F, Donnet A, Guedj E. Efficacy and mechanism of supervised adapted physical activity on quality of life for patients with fibromyalgia: single-center, prospective, randomised clinical and neuroimaging study. Sci Rep. 2026 Feb 3;16(1):5398. doi: 10.1038/s41598-025-33433-5.
- Sevgin O, Bugday B, Aydogan Baykara R, Gunendi G, Akkurt B, Atasoy H, Dikmen Hosbas B, Akkurt MF, Karamancioglu B. Efficacy of different exercises in women with fibromyalgia syndrome: a randomised controlled trial. Clin Exp Rheumatol. 2025 Jun;43(6):1010-1018. doi: 10.55563/clinexprheumatol/uol8so. Epub 2025 Feb 12.
- Fernandes G, Nery M, Meireles SM, Santos R, Natour J, Jennings F. A functional exercise program improves pain and health related quality of life in patients with fibromyalgia: a randomized controlled trial. Adv Rheumatol. 2024 Oct 24;64(1):81. doi: 10.1186/s42358-024-00422-7.
- Kundakci B, Hall M, Atzeni F, Branco J, Buskila D, Clauw D, Crofford LJ, Fitzcharles MA, Georgopoulos V, Gerwin RD, Kosek E, Macfarlane GJ, Neal C, Rudin NJ, Ryan S, da Silva JAP, Taylor AM, Turk DC, Whibley D, Doherty M, Zhang W, Abhishek A. International, multidisciplinary Delphi consensus recommendations on non-pharmacological interventions for fibromyalgia. Semin Arthritis Rheum. 2022 Dec;57:152101. doi: 10.1016/j.semarthrit.2022.152101. Epub 2022 Sep 24.
- Carrasco-Querol N, Cabricano-Canga L, Bueno Hernandez N, Goncalves AQ, Caballol Angelats R, Pozo Ariza M, Martin-Borras C, Monteso-Curto P, Castro Blanco E, Dalmau Llorca MR, Aguilar Martin C. Nutrition and Chronobiology as Key Components of Multidisciplinary Therapeutic Interventions for Fibromyalgia and Associated Chronic Fatigue Syndrome: A Narrative and Critical Review. Nutrients. 2024 Jan 5;16(2):182. doi: 10.3390/nu16020182.
- Rodriguez-Almagro D, Del Moral-Garcia M, Lopez-Ruiz MDC, Cortes-Perez I, Obrero-Gaitan E, Lomas-Vega R. Optimal dose and type of exercise to reduce pain, anxiety and increase quality of life in patients with fibromyalgia. A systematic review with meta-analysis. Front Physiol. 2023 Apr 12;14:1170621. doi: 10.3389/fphys.2023.1170621. eCollection 2023.
- Catala P, Ecija C, Serrano Del Moral A, Perez Viejo E, Penacoba C. Predicting Adherence to Walking from Anxiety, Depression, Disease Impact, Catastrophizing, and Cognitive Fusion in Patients with Fibromyalgia: Does Pain Severity Matter? Int J Environ Res Public Health. 2022 Dec 8;19(24):16453. doi: 10.3390/ijerph192416453.
- Castel A, Fontova R, Montull S, Perinan R, Poveda MJ, Miralles I, Cascon-Pereira R, Hernandez P, Aragones N, Salvat I, Castro S, Monterde S, Padrol A, Sala J, Anez C, Rull M. Efficacy of a multidisciplinary fibromyalgia treatment adapted for women with low educational levels: a randomized controlled trial. Arthritis Care Res (Hoboken). 2013 Mar;65(3):421-31. doi: 10.1002/acr.21818.
- Angst F, Lehmann S, Sandor PS, Benz T. Catastrophizing as a prognostic factor for pain and physical function in the multidisciplinary rehabilitation of fibromyalgia and low back pain. Eur J Pain. 2022 Aug;26(7):1569-1580. doi: 10.1002/ejp.1983. Epub 2022 Jun 11.
- Sanudo B, Galiano D, Carrasco L, de Hoyo M, McVeigh JG. Effects of a prolonged exercise program on key health outcomes in women with fibromyalgia: a randomized controlled trial. J Rehabil Med. 2011 May;43(6):521-6. doi: 10.2340/16501977-0814.
- Andrade A, Dominski FH, Sieczkowska SM. What we already know about the effects of exercise in patients with fibromyalgia: An umbrella review. Semin Arthritis Rheum. 2020 Dec;50(6):1465-1480. doi: 10.1016/j.semarthrit.2020.02.003. Epub 2020 Feb 14.
- Li X, Pan H, Wang L, Zhou Q, Ma Y, Wang Q, Wang M, Xie Z, Li H, Chen L, Huang L, Chen Y, Wen C. Guidelines on Treating Fibromyalgia With Nonpharmacological Therapies in China. J Evid Based Med. 2025 Jun;18(2):e70044. doi: 10.1111/jebm.70044.
- D'Onghia M, Ciaffi J, Ruscitti P, Cipriani P, Giacomelli R, Ablin JN, Ursini F. The economic burden of fibromyalgia: A systematic literature review. Semin Arthritis Rheum. 2022 Oct;56:152060. doi: 10.1016/j.semarthrit.2022.152060. Epub 2022 Jul 3.
- Ablin JN, Buskila D. Fibromyalgia syndrome--novel therapeutic targets. Maturitas. 2013 Aug;75(4):335-40. doi: 10.1016/j.maturitas.2013.05.004. Epub 2013 Jun 3.
Studiare le date dei record
Studia le date principali
Inizio studio (Effettivo)
Completamento primario (Effettivo)
Completamento dello studio (Effettivo)
Date di iscrizione allo studio
Primo inviato
Primo inviato che soddisfa i criteri di controllo qualità
Primo Inserito (Effettivo)
Aggiornamenti dei record di studio
Ultimo aggiornamento pubblicato (Effettivo)
Ultimo aggiornamento inviato che soddisfa i criteri QC
Ultimo verificato
Maggiori informazioni
Termini relativi a questo studio
Parole chiave
Altri numeri di identificazione dello studio
- Pain Intervention
- Social CreaLab, SCL 03i 2025 (Altro numero di sovvenzione/finanziamento: Playa Ancha University)
Piano per i dati dei singoli partecipanti (IPD)
Hai intenzione di condividere i dati dei singoli partecipanti (IPD)?
Descrizione del piano IPD
Periodo di condivisione IPD
Criteri di accesso alla condivisione IPD
Tipo di informazioni di supporto alla condivisione IPD
- STUDIO_PROTOCOLLO
- LINFA
- RSI
Informazioni su farmaci e dispositivi, documenti di studio
Studia un prodotto farmaceutico regolamentato dalla FDA degli Stati Uniti
Studia un dispositivo regolamentato dalla FDA degli Stati Uniti
Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .