Genetic Component of Handedness
Mapping the Genetic Component of Hand-Use Preference
Some functions are generally controlled by the right side of the brain and others by the left. One of the most easily observed examples of this "lateral specialization" of the brain is handedness-that is, a person's preference for using either the right or the left hand. This study will try to determine how the genetic component of handedness is inherited. It will test the theory that a single gene is involved in determining handedness and will try to locate the gene.
Families with at least two left-handed siblings aged eight years or older and at least one right-handed parent are eligible to participate in this study.
The left-handed siblings and both parents will fill out a brief questionnaire on hand usage, obtain a tissue sample taken from inside the cheek, and return the questionnaire and the sample by mail to the study researchers. The tissue sample will be used for DNA gene mapping.
Participants will be given a kit and instructions for obtaining the sample, along with mailing envelopes. Cheek swab sampling basically involves using a small brush to gently brush a layer of cells off of the inner wall of the cheek and then dropping the brush tip into a preservative.
The information gained from this study may provide insight into aspects of brain development that can be of medical benefit in the future.
調査の概要
状態
条件
詳細な説明
研究の種類
入学
連絡先と場所
研究場所
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Maryland
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Bethesda、Maryland、アメリカ、20892
- National Cancer Institute (NCI)
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参加基準
適格基準
就学可能な年齢
- 子
- 大人
- 高齢者
健康ボランティアの受け入れ
受講資格のある性別
説明
INCLUSION CRITERIA:
Members of families meeting the following criteria are eligible to participate:
Have two left-handed siblings.
Have at least one right-handed parent with no other known left-handed first degree relatives.
EXCLUSION CRITERIA:
All members of a family may be excluded if the right-handed parents or the left-handed siblings will not participate.
Individuals in families whose left-handed siblings are under the age of eight are not eligible to participate.
研究計画
研究はどのように設計されていますか？
協力者と研究者
出版物と役立つリンク
一般刊行物
- Corballis MC. The genetics and evolution of handedness. Psychol Rev. 1997 Oct;104(4):714-27. doi: 10.1037/0033-295x.104.4.714.
- Dellatolas G, Luciani S, Castresana A, Remy C, Jallon P, Laplane D, Bancaud J. Pathological left-handedness. Left-handedness correlatives in adult epileptics. Brain. 1993 Dec;116 ( Pt 6):1565-74. doi: 10.1093/brain/116.6.1565.
- Levin M, Nascone N. Two molecular models of initial left-right asymmetry generation. Med Hypotheses. 1997 Nov;49(5):429-35. doi: 10.1016/s0306-9877(97)90092-x.
研究記録日
主要日程の研究
研究開始
研究の完了
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (見積もり)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
その他の研究ID番号
- 000094
- 00-C-0094
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。