- ICH GCP
- Amerikanska kliniska prövningsregistret
- Klinisk prövning NCT00005003
Genetic Component of Handedness
Mapping the Genetic Component of Hand-Use Preference
Some functions are generally controlled by the right side of the brain and others by the left. One of the most easily observed examples of this "lateral specialization" of the brain is handedness-that is, a person's preference for using either the right or the left hand. This study will try to determine how the genetic component of handedness is inherited. It will test the theory that a single gene is involved in determining handedness and will try to locate the gene.
Families with at least two left-handed siblings aged eight years or older and at least one right-handed parent are eligible to participate in this study.
The left-handed siblings and both parents will fill out a brief questionnaire on hand usage, obtain a tissue sample taken from inside the cheek, and return the questionnaire and the sample by mail to the study researchers. The tissue sample will be used for DNA gene mapping.
Participants will be given a kit and instructions for obtaining the sample, along with mailing envelopes. Cheek swab sampling basically involves using a small brush to gently brush a layer of cells off of the inner wall of the cheek and then dropping the brush tip into a preservative.
The information gained from this study may provide insight into aspects of brain development that can be of medical benefit in the future.
Studieöversikt
Status
Betingelser
Detaljerad beskrivning
Studietyp
Inskrivning
Kontakter och platser
Studieorter
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Maryland
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Bethesda, Maryland, Förenta staterna, 20892
- National Cancer Institute (NCI)
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Deltagandekriterier
Urvalskriterier
Åldrar som är berättigade till studier
- Barn
- Vuxen
- Äldre vuxen
Tar emot friska volontärer
Kön som är behöriga för studier
Beskrivning
INCLUSION CRITERIA:
Members of families meeting the following criteria are eligible to participate:
Have two left-handed siblings.
Have at least one right-handed parent with no other known left-handed first degree relatives.
EXCLUSION CRITERIA:
All members of a family may be excluded if the right-handed parents or the left-handed siblings will not participate.
Individuals in families whose left-handed siblings are under the age of eight are not eligible to participate.
Studieplan
Hur är studien utformad?
Samarbetspartners och utredare
Sponsor
Publikationer och användbara länkar
Allmänna publikationer
- Corballis MC. The genetics and evolution of handedness. Psychol Rev. 1997 Oct;104(4):714-27. doi: 10.1037/0033-295x.104.4.714.
- Dellatolas G, Luciani S, Castresana A, Remy C, Jallon P, Laplane D, Bancaud J. Pathological left-handedness. Left-handedness correlatives in adult epileptics. Brain. 1993 Dec;116 ( Pt 6):1565-74. doi: 10.1093/brain/116.6.1565.
- Levin M, Nascone N. Two molecular models of initial left-right asymmetry generation. Med Hypotheses. 1997 Nov;49(5):429-35. doi: 10.1016/s0306-9877(97)90092-x.
Studieavstämningsdatum
Studera stora datum
Studiestart
Avslutad studie
Studieregistreringsdatum
Först inskickad
Först inskickad som uppfyllde QC-kriterierna
Första postat (Uppskatta)
Uppdateringar av studier
Senaste uppdatering publicerad (Uppskatta)
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
Senast verifierad
Mer information
Termer relaterade till denna studie
Nyckelord
Andra studie-ID-nummer
- 000094
- 00-C-0094
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