Effect of a Physical Activity Program on the Hormonal Regulation of Food Intake (APHRO)
Effect of a 3 Months Physical Activity Program on the Hormonal Regulation of Food Intake by Intense Physical Activity in Overweight Adolescents
The primary purpose of this protocol is to assess the hormonal regulation of satiety by an intense exercise before and after a 3 month physical activity program. Hormones assessed are: leptin, grhélin, Cholecystokinin, Glucagon-Like-Peptid-1 (GLP-1), PYY.
It is well known that in overweight adults and children also, an intense physical exercise diminish the food intake relatively to the total energy expenditure and this effect is persistent after a 6 weeks physical activity program.
Our hypothesis are: a diminution of food intake after the intense physical exercise and a persistent diminution of food intake after the 3 month physical activity program, an augmentation of levels of GLP-1 and PYY during the intense exercise before and after the physical activity program, a diminution of the level of GLP-1 and leptin before and after the physical activity program
調査の概要
詳細な説明
There is two sequences, one before and one after the physical activity program. Each sequence contains one "rest" session and one "exercise" session.
Each session contains : blood sample at regular interval (Leptin, Ghrélin, CCK, PYY, GLP-1), a sleeping assessment (Pittsburg scale), an assessment of hunger sensations at regular interval, an assessment of food intake in a "ad libitum" lunch and in the diner indirectly by the SU.VI.MAX. tool.
During the " rest " session :
Blood samples, assessment of hunger sensation, assessment of food intake are realized during the morning. Physical condition (VO2 max, DEXA, and muscular test), insulin-sensibility, lipid profile, are also assessed.
During the "exercise" session: it is identical to the first session but an intense exercise of 40 minutes is realized at 70% of the patient's VO2 max. The peripherical blood output is measured by a non-invasive method: the Near-Infra-Red-Spectroscopy, during the exercise.
The 3-months-physical activity program : there is 4 sessions of 30 minutes and 2 sessions of 1 hour per week. Most of exercises sessions are realized at home but one 1-hour session per week is controled with a sports educator.
研究の種類
入学 (予想される)
段階
- 適用できない
連絡先と場所
研究場所
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-
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Clermont-Ferrand、フランス、63003
- CHU clermont-ferrand
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-
参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
Overweight adolescents (over the 90 th percentile of the international cut-off point)
- With a computer and an internet connection
- Sedentary (according to the IPAQ-A questionnaire)
- Without eating disorders (according to the DEBQ questionnaire)
Exclusion Criteria:
- Medical or surgical antecedents that are incompatible with the study: cardiovascular, endocrine or digestive disease.
- Drugs that could interfere with the results of the study
- Surgical intervention in the 3 months
- Regular consumption of tobacco or Alcohol
- patients on a diet with caloric restriction
- Refusal to sign the consent form
- Regular practice of sport and intensive
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：処理
- 割り当て：なし
- 介入モデル：単一グループの割り当て
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
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実験的：obesity
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There is two sequences, one before and one after the physical activity program.
Each sequence contains one "rest" session and one "exercise" session
|
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
時間枠 |
|---|---|
|
Comparison before and after the physical activity program of the effect of intense exercise on kinetic of secretion of regulation hormones: Leptin, Grhélin, CCK, PYY3-36, GLP-1
時間枠：after 3 months of physical activity
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after 3 months of physical activity
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二次結果の測定
結果測定 |
時間枠 |
|---|---|
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Comparison, before and after the physical activity program, of Hunger sensation by Visual Analogic Scales
時間枠：after 3 months of physical activity
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after 3 months of physical activity
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Comparison, before and after the physical activity program of food intake
時間枠：after 3 months of physical activity
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after 3 months of physical activity
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Comparison, before and after the physical activity program of insulinosensibility
時間枠：after 3 months of physical activity
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after 3 months of physical activity
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Comparison, before and after the physical activity program of peripheral blood output
時間枠：after 3 months of physical activity
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after 3 months of physical activity
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Comparison, before and after the physical activity program of sleep quality
時間枠：agter 3 months of physical activity
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agter 3 months of physical activity
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Comparison, before and after the physical activity program of physical condition
時間枠：after 3 months of physical activity
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after 3 months of physical activity
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協力者と研究者
捜査官
- 主任研究者：Etienne Merlin、University Hospital, Clermont-Ferrand
研究記録日
主要日程の研究
研究開始
一次修了 (予想される)
研究の完了 (予想される)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (見積もり)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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