Effect of a Physical Activity Program on the Hormonal Regulation of Food Intake (APHRO)
Effect of a 3 Months Physical Activity Program on the Hormonal Regulation of Food Intake by Intense Physical Activity in Overweight Adolescents
The primary purpose of this protocol is to assess the hormonal regulation of satiety by an intense exercise before and after a 3 month physical activity program. Hormones assessed are: leptin, grhélin, Cholecystokinin, Glucagon-Like-Peptid-1 (GLP-1), PYY.
It is well known that in overweight adults and children also, an intense physical exercise diminish the food intake relatively to the total energy expenditure and this effect is persistent after a 6 weeks physical activity program.
Our hypothesis are: a diminution of food intake after the intense physical exercise and a persistent diminution of food intake after the 3 month physical activity program, an augmentation of levels of GLP-1 and PYY during the intense exercise before and after the physical activity program, a diminution of the level of GLP-1 and leptin before and after the physical activity program
研究概览
详细说明
There is two sequences, one before and one after the physical activity program. Each sequence contains one "rest" session and one "exercise" session.
Each session contains : blood sample at regular interval (Leptin, Ghrélin, CCK, PYY, GLP-1), a sleeping assessment (Pittsburg scale), an assessment of hunger sensations at regular interval, an assessment of food intake in a "ad libitum" lunch and in the diner indirectly by the SU.VI.MAX. tool.
During the " rest " session :
Blood samples, assessment of hunger sensation, assessment of food intake are realized during the morning. Physical condition (VO2 max, DEXA, and muscular test), insulin-sensibility, lipid profile, are also assessed.
During the "exercise" session: it is identical to the first session but an intense exercise of 40 minutes is realized at 70% of the patient's VO2 max. The peripherical blood output is measured by a non-invasive method: the Near-Infra-Red-Spectroscopy, during the exercise.
The 3-months-physical activity program : there is 4 sessions of 30 minutes and 2 sessions of 1 hour per week. Most of exercises sessions are realized at home but one 1-hour session per week is controled with a sports educator.
研究类型
注册 (预期的)
阶段
- 不适用
联系人和位置
学习地点
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Clermont-Ferrand、法国、63003
- CHU clermont-ferrand
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
Overweight adolescents (over the 90 th percentile of the international cut-off point)
- With a computer and an internet connection
- Sedentary (according to the IPAQ-A questionnaire)
- Without eating disorders (according to the DEBQ questionnaire)
Exclusion Criteria:
- Medical or surgical antecedents that are incompatible with the study: cardiovascular, endocrine or digestive disease.
- Drugs that could interfere with the results of the study
- Surgical intervention in the 3 months
- Regular consumption of tobacco or Alcohol
- patients on a diet with caloric restriction
- Refusal to sign the consent form
- Regular practice of sport and intensive
学习计划
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：不适用
- 介入模型：单组作业
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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实验性的：obesity
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There is two sequences, one before and one after the physical activity program.
Each sequence contains one "rest" session and one "exercise" session
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研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
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Comparison before and after the physical activity program of the effect of intense exercise on kinetic of secretion of regulation hormones: Leptin, Grhélin, CCK, PYY3-36, GLP-1
大体时间：after 3 months of physical activity
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after 3 months of physical activity
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次要结果测量
结果测量 |
大体时间 |
|---|---|
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Comparison, before and after the physical activity program, of Hunger sensation by Visual Analogic Scales
大体时间：after 3 months of physical activity
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after 3 months of physical activity
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Comparison, before and after the physical activity program of food intake
大体时间：after 3 months of physical activity
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after 3 months of physical activity
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Comparison, before and after the physical activity program of insulinosensibility
大体时间：after 3 months of physical activity
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after 3 months of physical activity
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Comparison, before and after the physical activity program of peripheral blood output
大体时间：after 3 months of physical activity
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after 3 months of physical activity
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Comparison, before and after the physical activity program of sleep quality
大体时间：agter 3 months of physical activity
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agter 3 months of physical activity
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Comparison, before and after the physical activity program of physical condition
大体时间：after 3 months of physical activity
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after 3 months of physical activity
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合作者和调查者
调查人员
- 首席研究员：Etienne MERLIN、University Hospital, Clermont-Ferrand
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.
Physical activity的临床试验
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University of North Carolina, Chapel HillNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Splendor-NC招聘中
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Weill Medical College of Cornell UniversityWeill Cornell Medical College in Qatar撤销